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Stimulus-Responsive Oligonucleotide Conjugation

BOC Sciences is an expert in conjugation technology, focusing on providing the highest quality stimulus-responsive oligonucleotides. At BOC Sciences you will get inspiration for drug delivery and potency enhancement. With our state-of-the-art manufacturing facilities, we are well positioned to meet your needs for novel conjugates.

What is Stimulus-Responsive Oligonucleotide Conjugation?

Stimulus-responsive oligonucleotide conjugations are oligonucleotide-based conjugates that are capable of responding to specific external stimuli by undergoing structural or functional changes in response to the stimulus, thereby allowing for controlled release, activation, or modulation of their properties.

Stimulus-responsive environmental conditions.Figure 1. Stimulus-responsive environmental conditions. (Zhongyu, Y; et al, 2022)

Various types of stimulus-responsive oligonucleotide conjugates are designed using a variety of stimuli, including changes in pH, temperature, light, enzyme activity, or the presence of specific molecules.

Introduction of Stimulus-Responsive Oligonucleotide Conjugation Services

ServiceStimulus-Responsive Oligonucleotide Conjugation
Customer providesOligonucleotide sequence
PurificationQC analysis by MS, HPLC, or PAGE
DeliveryTypical delivery is lyophilized samples in individual vials that are fully labeled
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  1. Stimulus-Responsive Oligonucleotide Conjugation Design: BOC Sciences assists in the selection of suitable response switch (pH, temperature, light, enzyme) and custom synthesis of oligonucleotides according to the client's needs and provides an optimised service process.
  2. Stimulus-Responsive Oligonucleotide Conjugation Preparation: BOC Sciences adopts appropriate strategies for stimulus-responsive oligonucleotide conjugation preparation under strict quality standards.
  3. Stimulus-Responsive Oligonucleotide Conjugation Purification: BOC Sciences uses proprietary and efficient purification techniques to separate the coupling product from the unreacted feedstock, ensuring the purity and activity of the coupling product.
  4. Stimulus-Responsive Oligonucleotide Conjugation Characterization: BOC Sciences performs analysis of the products using a variety of characterisation techniques such as mass spectrometry and nuclear magnetic resonance to ensure high purity and accurate structure of the products.

Service flow of stimulus-responsive oligonucleotide conjugation.- BOC SciencesFigure 2. Service flow of stimulus-responsive oligonucleotide conjugation.

  1. Efficient reaction conditions and reagent selection to ensure optimum binding efficiency and yield.
  2. Flexible and reliable production capacity to guarantee on-time completion of large, small and custom orders.
  3. Fast response and excellent customer service to achieve timely resolution of customer problems and needs.
  4. Optimised and time-tested processes to provide fast turnaround times and improve overall efficiency.

Reference

  1. Zhongyu, Y; et al. Stimulus-Responsive Hydrogels In Food Science: A Review. Food Hydrocolloids. 2022, 124: 107218.
* Only for research. Not suitable for any diagnostic or therapeutic use.
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