Stearyl Labeling of Oligonucleotides

The stearyl group is a straight-chain fatty acid moiety consisting of 18 carbon atoms and is hydrophobic. Introducing a stearyl group into an oligonucleotide molecule can change its hydrophobicity and lipophilicity, thus expanding the applications of oligonucleotides. BOC Sciences provides high-quality stearyl-labeled oligonucleotides to our customers, as well as subsequent validation and characterization of stearyl-labeled oligonucleotides to facilitate the development of projects.

What is Stearyl?

Stearyl has excellent properties, such as good hydrophobicity and strong affinity. These properties allow stearyl-labeled oligonucleotides to have good solubility and stability in hydrophobic media, improve their uptake and internalization efficiency in cells, and help to improve drug delivery and prolong their duration of action in cells.

BOC Science's Labeled Oligonucleotide Services

• Stearyl-labeled oligonucleotide services

BOC Science offers many types of stearyl labeled oligonucleotide services.

• Stearyl alcohol labeled oligonucleotide services

BOC Sciences offers stearyl alcohol labeled oligonucleotide services. Stearyl alcohol labeled oligonucleotides are oligonucleotides that are modified to have a stearyl alcohol moiety. This labeling is typically achieved by introducing a stearyl alcohol moiety at a specific position in the oligonucleotide. The modified oligonucleotide can have altered hydrophobic and lipophilic properties.

• Stearyl cholesterol labeled oligonucleotide services

BOC Sciences can obtain stearyl cholesterol-labeled oligonucleotides by chemical synthesis. Prior to labeling, a modified molecule containing a stearyl cholesterol moiety is designed and synthesized, which is then conjugated to the oligonucleotide to obtain the target oligonucleotide marker.

• Stearyl glyceryl ether labeling service for oligonucleotides

Stearyl glyceryl ether is an ether compound consisting of a stearyl group bound to glycerol. BOC Sciences introduces good permeability and lipophilicity to the oligonucleotide after labeling with stearyl glyceryl ether.

• Validation and characterization of stearyl labeled oligonucleotides

Validation of stearyl-labeled oligonucleotides provided by BOC Sciences includes a variety of techniques, such as mass spectrometry, nuclear magnetic resonance, gel electrophoresis, high-performance liquid chromatography, UV-visible, circular dichroism spectroscopy, fluorescence spectroscopy, and more. Our validation and characterization services ensure the accuracy and reliability of the labeled oligonucleotides obtained.

In addition to the above services, BOC Sciences can also provide customers with large-scale production of labeled oligonucleotides and establish a quality management system to ensure the consistency and high quality of the products obtained by customers.

Applications of Stearyl-labeled Oligonucleotides

• Enhanced cell penetration

Stearyl-labeled oligonucleotides can form hydrophobic interactions on cell membranes through their lipophilic stearyl groups, thus enhancing their cell penetration.

• Targeted delivery

The lipophilic nature of the stearyl moiety allows the modified oligonucleotide to interact more efficiently with the lipid bilayer and enrich on the target cells, thus enhancing the efficiency and specificity of delivery.

• Inhibitor stabilization

Stearyl-labeled oligonucleotides increase their stability and reduce susceptibility to degradation by nucleases.

• Bioimaging

Visualization or quantitative detection of oligonucleotides can be achieved by attaching markers such as fluorescent dyes or radioisotopes to the stearyl moiety. This has significant application potential in areas such as cellular imaging, in vivo small animal imaging and molecular diagnostics.

BOC Sciences offers a wide range of stearyl-labeled oligonucleotide services for a variety of applications. If you are interested in our services, feel free to contact us.

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Stearyl Labeling of Oligonucleotides

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