As a leading supplier of oligonucleotides, BOC Sciences is committed to providing our customers with comprehensive modification and labeling, offering affordable custom oligonucleotides or GalNAc-oligonucleotide conjugates.
N-Acetylgalactosamine Oligonucleotide Conjugates
Concept of GalNAc-Oligonucleotide Conjugation
GalNAc-oligonucleotide conjugation is a method of covalently binding oligonucleotides to N-acetylgalactose (GalNAc), thereby altering its molecular structure and improving the distribution and stability of the drug in the liver. Specifically, GalNAc is a high-affinity ligand that enters the hepatocytes of the liver and is recognized and bound by the GalNAc receptor in the liver, thus enabling target delivery.
How to Achieve GalNAc-Oligonucleotide Conjugation
GalNAc-oligonucleotide conjugation requires multiple steps. First, an oligonucleotide molecule needs to be designed and synthesized. Then, a C3-GalNAc modifier is introduced at the 3' end of the molecule or a C2 or C5 modifier is introduced directly within the oligonucleotide molecule to modify GalNAc. Next, activation is performed and GalNAc-oligonucleotide is reacted with an activator to form a new compound covalently linked to GalNAc-oligonucleotide. Finally, the compounds were purified and prepared into drugs using relevant methods.
Application of GalNAc-Oligonucleotide Conjugation
GalNAc-oligonucleotide conjugation has been widely used in the treatment of genetic diseases such as liver fibrosis, lipid-like deposits and hepatitis C. Among them, alkylated and 2'F modified nucleotides as the development direction can greatly enhance the biostability and targeting of GalNAc-oligonucleotide conjugation.
Introduction to GalNAc-Oligonucleotide Conjugation Services
| Service | GalNAc-Oligonucleotide Conjugation |
| Customer provides | Oligonucleotide sequence |
| Purification | QC analysis by MS, HPLC, or PAGE |
| Delivery | Typical delivery is lyophilized samples in individual vials that are fully labeled |
| Request a Quote | Inquiry |
What Are Our GalNAc-Oligonucleotide Conjugation Services?
- Synthesis of Oligonucleotide: BOC Sciences' professional synthesis team can synthesize oligonucleotide to meet the specific needs of our customers
- Specific Conjugation Methods: BOC Sciences offers different conjugation methods (including organic chemistry and biological methods) to conjugate GalNAc groups to oligonucleotide
- Determination of Conjugate Purity: The purity of the conjugate is assessed using techniques such as HPLC or PAGE.
- Long-term Storage of Conjugates: GalNAc-oligonucleotide conjugates can be stored for long periods of time by freezing or solution storage.
- Stability Testing: The stability of the conjugates is assessed using various stability testing methods such as long-term storage and examination of heating or cooling.
- Other Specific Customer Needs: Services specifically tailored to the specific needs of the customer for GalNAc-oligonucleotide conjugates.
Advantages of Our GalNAc-Oligonucleotide Conjugates
- Professional Expertise: BOC Sciences boasts a team of seasoned scientific professionals and cutting-edge technical equipment, ensuring exceptional conjugation services of the highest quality.
- Synthesis Excellence: Using only premium raw materials and advanced reaction techniques, BOC Sciences employs a superior synthesis process to produce products of incredible purity and stability.
- Affordable Quality: BOC Sciences prides itself on meeting customer needs without compromising on quality, delivering reasonable prices for unparalleled service.
- Customizable Solutions: BOC Sciences offers flexible conjugation services that can be tailored to suit the diverse research needs of a range of customers across various fields.
- Time-Efficient Support: BOC Sciences' dedicated team of service experts operates with efficient speed and responsiveness, ensuring swift project completion and timely fulfillment of client requirements.
* Only for research. Not suitable for any diagnostic or therapeutic use.
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