Focused on powering drug delivery and enhancing drug efficacy through bioconjugation technology, BOC Sciences has state-of-the-art manufacturing facilities and comprehensive experience in conjugation technology to combine oligonucleotides with antibiotics. We have the ability and confidence to meet your needs for novel conjugates.
Coupling an antibiotic molecule to an oligonucleotide results in antibiotic-oligonucleotide conjugation, which allows the combination of the antibacterial properties of the antibiotic with the sequence-specific targeting ability of the oligonucleotide. The resulting antibiotic-oligonucleotide conjugation will exhibit enhanced performance compared to the individual components.
The first step in the binding process is the chemical modification of the antibiotic or oligonucleotide to introduce reactive functional groups. The modified moiety can then be used to create a covalent bond between the antibiotic and the oligonucleotide. It is recommended that various strategies and splice molecules are used to facilitate this bonding while still maintaining the stability and activity of the two components.
In antibiotic-oligonucleotide conjugations, oligonucleotides can be designed to target characteristic nucleic acid sequences to achieve targeting, while antibiotics can be used to kill microbes or viruses and advance bacterial resistance studies.
| Service | Antibiotic-Oligonucleotide Conjugation |
| Customer provides | Oligonucleotide sequence |
| Purification | QC analysis by MS, HPLC, or PAGE |
| Delivery | Typical delivery is lyophilized samples in individual vials that are fully labeled |
| Request a Quote | Inquiry |
1. Oligonucleotide Sequence Synthesis: BOC Sciences can synthesise oligonucleotide sequences according to the client's requirements and needs.
2. Antibiotic Selection: BOC Sciences' team of experts will provide appropriate advice for the client's needs.
3. Preparation of Antibiotic-Oligonucleotide Conjugations: BOC Sciences can couple the synthesised antibiotics to the oligonucleotides and purify and characterise the couples.
4. Optimisation of Conjugation Reactions: BOC Sciences can optimise the reaction conditions to improve the yield of antibiotic-oligonucleotide couplings and the purity of the couples.
5. Purification Analysis: BOC Sciences can purify and analyse antibiotic-oligonucleotide conjugates using a variety of techniques and methods, including HPLC, mass spectrometry and more.
6. Customised Services: BOC Sciences can provide customised antibiotic-oligonucleotide coupling services to meet the specific needs and requirements of our customers.
Figure 1. Service flow of antibiotic-oligonucleotide conjugation.
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