Enzyme-Oligonucleotide Conjugation

BOC Sciences focuses on powering drug delivery through bioconjugation. Relying on our state-of-the-art manufacturing facilities and comprehensive experience in conjugation technologies, BOC Sciences provides conjugation services to combine oligonucleotides with enzyme. We have the capability and confidence to meet your needs for novel conjugates.

What is Enzyme-Oligonucleotide Conjugation

Enzyme-oligonucleotide conjugation is a novel area of drug research that combines two molecules, an enzyme and an oligonucleotide, to form a complex with specific biological activity.

• Mode of Enzyme-Oligonucleotide Conjugation

The basic principle of the conjugation process between enzymes and oligonucleotides is determined by the method of binding employed. There are generally two techniques used in modern research: covalent and non-covalent binding. Covalent binding involves altering the structure of oligonucleotides to include reactive groups that can form covalent bonds with amino acid residues found in the enzyme. On the other hand, non-covalent binding involves the enzyme adhering to the oligonucleotide through non-covalent forces, including electrostatic interactions, hydrogen bonds, and van der Waals forces.

• Biological Activity of Enzyme-Oligonucleotide Conjugation

The biological activity of enzyme-oligonucleotide conjugation is the key to its application prospects. It has been shown that enzyme-oligonucleotide conjugation can specifically recognize and target the corresponding cells or tissues in vivo. This can be achieved by designing oligonucleotide sequences to be complementary to the target molecule in the target cell or tissue. In addition, enzyme-oligonucleotide conjugation can regulate cellular signaling pathways, inhibit the proliferation of viruses and cancer cells, etc.

• Applications of Enzyme-Oligonucleotide Conjugation in Gene Therapy

Enzyme-oligonucleotide conjugation offers tremendous potential for advancing the field of gene therapy, by enabling precise targeting of genes to specific cells and regulation of gene expression. By fusing gene and oligonucleotide sequences, it is possible to create enzyme-oligonucleotide conjugates, which simplify and streamline the delivery of genetic material.

• Application of Enzyme-Oligonucleotide Conjugation in Drug Delivery

Enzyme-oligonucleotide conjugation also has a wide range of promising applications in drug delivery. By combining drugs with oligonucleotide sequences to form enzyme-oligonucleotide conjugation, it is possible to make the drugs enter the target cells specifically and reduce the toxic side effects of the drugs. In addition, enzyme-oligonucleotide conjugation can also improve the efficacy of drugs by altering the metabolic pathway and pharmacokinetics of the drugs.

Introduction to Enzyme-Oligonucleotide Conjugation Services

• What Are Our Enzyme-Oligonucleotide Conjugation Services?

1. Design and synthesize suitable oligonucleotides (oligonucleotides), including DNA and RNA.
2. Select and prepare suitable enzymes, such as peroxidase, alkaline phosphatase, streptavidinase, etc.
3. Perform enzyme-oligonucleotide covalent binding reaction to ensure effective binding and stability.
4. Purify and analyze products to ensure their quality and purity.
5. Provide customized services for custom oligonucleotide and enzyme selection according to customer requirements.
6. Provide efficient service and ensure fast delivery.
7. Provide quantitative reports and analytical results to ensure customer satisfaction.
8. Provide technical support and consulting services to help customers optimize experimental design and analysis of results.

• Why Choose Our Enzyme-Oligonucleotide Conjugates

1. High purity: BOC Sciences' enzyme-oligonucleotide conjugation service uses high quality enzymes and oligonucleotides to ensure high purity of the resulting product.
2. High stability: BOC Sciences' enzyme-oligonucleotide conjugation service uses stable linkage chemistry, and the products are extremely stable and resistant to decomposition or degradation.
3. High efficiency: BOC Sciencess uses specialized techniques and equipment to ensure efficient reactions and high yields of products.
4. Customization: BOC Sciences' enzyme-oligonucleotide conjugation services can be customized to meet a variety of different research needs.
5. Professional team: BOC Sciences' enzyme-oligonucleotide conjugation service has a professional team with rich experience and expertise to provide high quality service and technical support.