BOC Sciences focuses on powering drug delivery through bioconjugation. Relying on our state-of-the-art manufacturing facilities and comprehensive experience in conjugation technologies, BOC Sciences offers conjugation services to combine oligonucleotides with exosomes. We indeed have the capability to meet your needs for novel conjugates.
Overview of Exosome-Oligonucleotide Conjugation
Exosomes are small extracellular vesicles released by cells and play a role in intercellular communication by transferring biomolecules such as proteins, RNA and DNA between cells. In exosome-oligonucleotide conjugation, exosomes act as carriers to protect oligonucleotides from degradation and to facilitate their transport to specific cells or tissues.
Figure 1. Exosomes. (Zipkin, M, 2019)
Preparation of Exosome-Oligonucleotide Conjugation
The process of preparing an exosome-oligonucleotide conjugation typically involves modifying the surface of the exosome or oligonucleotide to produce a reactive group that can form a covalent bond. Various chemical or bioengineering techniques, such as click chemistry, lipid-based methods or genetic engineering methods, can be utilised to achieve the attachment of oligonucleotides to the surface of exosomes or to encapsulate them inside exosomes.
Application of Exosome-Oligonucleotide Conjugation
Based on the specific biological status of exosomes, exosome-oligonucleotide conjugation has great potential to advance the field of nucleic acid-based therapeutics and precision medicine.
- Promoting RNAi-based Gene Silencing
- Precise Gene Editing
- Vaccine & Immunotherapy Development
- Targeted Drug Delivery
- Diagnostic & Prognostic Biomarker Testing
Introduction of Exosome-Oligonucleotide Conjugation Services
| Service | Exosome-Oligonucleotide Conjugation |
| Customer provides | Oligonucleotide sequence |
| Purification | QC analysis by MS, HPLC, or PAGE |
| Delivery | Typical delivery is lyophilized samples in individual vials that are fully labeled |
| Request a Quote | Inquiry |
What Are Our Exosome-Oligonucleotide Conjugation Services?
BOC Sciences is committed to providing a personalised service, customising designs and fabrications to meet customer requirements.
- The first step is to select the appropriate chemical coupling method, including cross-linking agents, cross-linker activation and chemical modifications.
- In the second step, a wide range of oligonucleotides of different lengths are provided to meet the needs of different applications.
- And in the third step, a wide range of different types of exosomes are provided for selection. (Exosomes can be isolated from various cell types, such as immune cells, stem cells, cancer cells or specific tissue types.)
- Then in the fourth step, efficient purification techniques ensure the purity and activity of the coupling products.
- Next in the fifth step, comprehensive quality control and analytical services are provided, including mass spectrometry, high performance liquid chromatography and gel electrophoresis analysis.
- The final step is to provide professional technical support and advisory services to assist customers in solving various problems and difficulties.
Figure 2. Service flow of exosome-oligonucleotide conjugation.
Why Choose Our Exosome-Oligonucleotide Conjugation Services?
- Strict Quality Control Standards: BOC Sciences adheres to strict quality control to ensure high quality delivery of exosome-oligonucleotide conjugation products.
- Highly Effective Isolation & Purification Technologies: BOC Sciences has proprietary and highly effective isolation and purification technologies to ensure the ultra-high purity of exosome-oligonucleotide conjugation products.
- Rapid Delivery: BOC Sciences' exosome-oligonucleotide conjugation service offers rapid delivery to meet the urgent needs of our customers.
- Wide Range of Applications: BOC Sciences' xosome-oligonucleotide conjugation has a wide range of applications spanning the pharmaceutical and drug delivery sectors.
Reference
- Zipkin, M. Exosome Redux. Nature Biotechnology. 2019, 37(12): 634: 1395–1400.
* Only for research. Not suitable for any diagnostic or therapeutic use.
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