BOC Sciences focuses on powering drug delivery through bioconjugation. Relying on our state-of-the-art manufacturing facilities and comprehensive experience in conjugation technologies, BOC Sciences provides conjugation services to combine oligonucleotides with glycomimetics. We have the capability and confidence to meet your needs for novel conjugates.
Antioxidant-oligonucleotide conjugation refers to the covalent attachment of antioxidant molecules to oligonucleotides, which is a binding strategy that combines the therapeutic potential of oligonucleotides with the antioxidant properties of specific molecules and aims to enhance the stability and efficacy of oligonucleotide-based therapies. Antioxidants scavenge reactive oxygen species (ROS) and prevent oxidative damage to molecules that can reduce the oxidative stress that can occur during oligonucleotide delivery, cellular uptake and intracellular processing. However, oxidative stress is one of the major causes of oligonucleotide degradation, inactivation and off-targeting.
Bifunctional junctions with antioxidant and oligonucleotide reaction groups are used, which allow selective binding of the antioxidant to specific sites on the oligonucleotide molecule. The choice of antioxidant depends on stability, ROS scavenging ability and compatibility with conjugation chemistry to meet the needs of research.
| Service | Antioxidant-Oligonucleotide Conjugation |
| Customer provides | Oligonucleotide sequence |
| Purification | QC analysis by MS, HPLC, or PAGE |
| Delivery | Typical delivery is lyophilized samples in individual vials that are fully labeled |
| Request a Quote | Inquiry |
1. Design and synthesis of suitable oligonucleotide sequences
2. Selection and preparation of suitable antioxidants
3. Chemical modification of oligonucleotides for antioxidant binding
4. Covalent binding of modified oligonucleotides to antioxidants
5. Purification and characterisation of the synthesised coupling products
6. Providing high quality products and detailed analytical reports
Figure 1. Service flow of antioxidant-oligonucleotide conjugation.
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