Antioxidant-Oligonucleotide Conjugation

BOC Sciences focuses on powering drug delivery through bioconjugation. Relying on our state-of-the-art manufacturing facilities and comprehensive experience in conjugation technologies, BOC Sciences provides conjugation services to combine oligonucleotides with glycomimetics. We have the capability and confidence to meet your needs for novel conjugates.

Overview of Antioxidant-Oligonucleotide Conjugation

Antioxidant-oligonucleotide conjugation refers to the covalent attachment of antioxidant molecules to oligonucleotides, which is a binding strategy that combines the therapeutic potential of oligonucleotides with the antioxidant properties of specific molecules and aims to enhance the stability and efficacy of oligonucleotide-based therapies. Antioxidants scavenge reactive oxygen species (ROS) and prevent oxidative damage to molecules that can reduce the oxidative stress that can occur during oligonucleotide delivery, cellular uptake and intracellular processing. However, oxidative stress is one of the major causes of oligonucleotide degradation, inactivation and off-targeting.

• How to Prepare Antioxidant-Oligonucleotide Conjugation

Bifunctional junctions with antioxidant and oligonucleotide reaction groups are used, which allow selective binding of the antioxidant to specific sites on the oligonucleotide molecule. The choice of antioxidant depends on stability, ROS scavenging ability and compatibility with conjugation chemistry to meet the needs of research.

• Highlight of Antioxidant-Oligonucleotide Conjugation in Therapy Development

• Antioxidant-oligonucleotide conjugations can enhance oligonucleotide stability by protecting oligonucleotides from oxidative degradation.
• Antioxidant-oligonucleotide conjugation can potentially improve the cellular uptake and intracellular transport of oligonucleotides, thereby enhancing therapeutic efficacy.
• Antioxidant-oligonucleotide conjugation may provide additional therapeutic benefits by modulating oxidative stress-related signalling pathways.

Introduction of Antioxidant-Oligonucleotide Conjugation Services

• What Are Our Antioxidant-Oligonucleotide Conjugation Services?

1. Design and synthesis of suitable oligonucleotide sequences

2. Selection and preparation of suitable antioxidants

• Ascorbic Acid (Vitamin C)
• Tocopherols (Vitamin E)
• Glutathione
• Catechin
• Carotenoids

3. Chemical modification of oligonucleotides for antioxidant binding

4. Covalent binding of modified oligonucleotides to antioxidants

5. Purification and characterisation of the synthesised coupling products

6. Providing high quality products and detailed analytical reports

Figure 1. Service flow of antioxidant-oligonucleotide conjugation.

• Why Choose Our Antioxidant-Oligonucleotide Conjugation Services?

• Customised Solution: BOC Sciences offers a tailored service to carry out specific antioxidant-oligonucleotide coupling reactions according to customer needs.
• Flexibility: BOC Sciences' antioxidant-oligonucleotide coupling services are flexible and can be adapted to a wide range of pharmaceutical applications.
• Cost-effectiveness: BOC Sciences' antioxidant-oligonucleotide coupling service is cost-effective and can help customers save on experimental costs.
• High Volume Production: BOC Sciences' antioxidant-oligonucleotide coupling service is highly efficient and suitable for high volume production, allowing for short and rapid delivery times.

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Antioxidant-Oligonucleotide Conjugation

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