BOC Sciences is always conmmitted to powering drug delivery and drug efficiency through bioconjugation. Relying on our state-of-the-art manufacturing facilities and comprehensive experience in conjugation technologies, BOC Sciences offers conjugation services to combine oligonucleotides with small molecules.
What is Small Molecule-Oligonucleotide Conjugation?
Small molecules and oligonucleotides can be chemically linked to form small molecule-oligonucleotide conjugates, which are valuable tools for the study of biological processes and interactions, and are widely used in controlled drug delivery, bioimaging and diagnostics.
Figure 1. Schematic diagram of a method for the synthesis of bifunctional small molecule-oligonucleotide hybrids. (Bhattarai, U; et al, 2020)
Types of Small Molecules Available
- Small molecule drugs (e.g. aspirin, paracetamol, statins, antibiotics, antivirals, chemotherapy drugs, etc.)
- Hormones and hormone-like substances (e.g. insulin, oestrogen, testosterone, adrenaline, cortisol, etc.)
- Enzyme cofactors (e.g. NADH, FAD, ATP, coenzyme A, etc.)
- Small molecule dyes (e.g. chlorophyll, etc.)
- Toxins (e.g. glyphosate, neonicotinoids, etc.)
- Metabolite molecules (e.g. glucose, lactate, citrate, acetyl coenzyme A, etc.)
Application of Small Molecule-Oligonucleotide Conjugation
- The direction of application of small molecule-oligonucleotide conjugation generally depends mainly on the type of small molecule, while the oligonucleotide component mainly confers sequence specificity.
- Small molecule components can provide fluorescent or radioactive properties for visualisation studies. Small molecule-oligonucleotide conjugations can be used as probes or sensors to image specific cellular targets or to detect the presence of specific nucleic acids.
- Small molecule-oligonucleotide conjugation can be used to selectively regulate gene expression, inhibit protein function or detect specific molecular interactions.
Introduction of Small Molecule-Oligonucleotide Conjugation Services
| Service | Small Molecule-Oligonucleotide Conjugation |
| Customer provides | Oligonucleotide sequence |
| Purification | QC analysis by MS, HPLC, or PAGE |
| Delivery | Typical delivery is lyophilized samples in individual vials that are fully labeled |
| Request a Quote | Inquiry |
What Are Our Small Molecule-Oligonucleotide Conjugation Services?
- BOC Sciences' expert team will synthesise the oligonucleotide and then chemically link it to obtain the small molecule-oligonucleotide conjugation according to the customer's requirements.
- BOC Sciences has been working on optimising different types of synthesis protocols to ensure high product purity and yield.
- BOC Sciences has specialised characterisation platforms and purification techniques to ensure the correct purity and structure of small molecule-oligonucleotide conjugation.
- Quality Assurance: BOC Sciences adheres to high quality standards in all synthesis, characterisation and analytical processes to ensure customer satisfaction.
Figure 2. Service flow of small molecule-oligonucleotide conjugation.
Why Choose Our Small Molecule-Oligonucleotide Conjugation Services?
- BOC Sciences has optimised and well-tested reaction conditions and reagent selection to ensure optimum bonding efficiency and yield.
- BOC Sciences offers a wide range of crosslinkers and crosslinking methods to meet the different needs of our customers.
- BOC Sciences has a dedicated technical team to ensure technical support and standardised operating procedures.
- BOC Sciences' ability to respond quickly and with excellent customer service ensures that customer problems and needs are resolved in a timely manner.
Reference
- Bhattarai, U; et al. Bifunctional Small Molecule-Oligonucleotide Hybrid As Microrna Inhibitor. Bioorganic & Medicinal Chemistry. 2020, 11: 115394-115421.
* Only for research. Not suitable for any diagnostic or therapeutic use.
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