Phosphoramidites

N2-Isobutyryl-N-trityl-morpholinoguanosine

Description: N2-Isobutyryl-N-trityl-morpholinoguanosine is a modified form of guanosine, a nucleoside commonly used in oligonucleotide synthesis and related molecular biology applications. In this compound, the guanosine base is modified with an isobutyryl (Isobutyryl) group and a trityl (Trityl) group. Additionally, a morpholino moiety is present in the structure. These modifications serve to protect the guanosine base during oligonucleotide synthesis, allowing for controlled nucleotide incorporation and facilitating subsequent reactions. This compound finds utility in the synthesis of modified nucleic acids for research and diagnostic purposes.

CAT: BRP-00377

CAS: 956139-24-5

Molecular Formula: C33H34N6O4

Molecular Weight: 578.66

Purity: ≥95%

Appearance: White to yellow powder

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Storage: Store at 2-8°C

Density: 1.3±0.1 g/cm3

Melting Point: 198°C

InChIKey: LNQQABQFAZWVNX-RRPNLBNLSA-N

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3CN(CC(O3)CO)C(C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=CC=C6

IUPAC Name: N-[9-[(2R,6S)-6-(hydroxymethyl)-4-tritylmorpholin-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide

InChI: InChI=1S/C33H34N6O4/c1-22(2)30(41)36-32-35-29-28(31(42)37-32)34-21-39(29)27-19-38(18-26(20-40)43-27)33(23-12-6-3-7-13-23,24-14-8-4-9-15-24)25-16-10-5-11-17-25/h3-17,21-22,26-27,40H,18-20H2,1-2H3,(H2,35,36,37,41,42)/t26-,27+/m0/s1

Synonyms: N-[6,9-Dihydro-9-[(2R,6S)-6-(hydroxymethyl)-4-(triphenylmethyl)-2-morpholinyl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide; N-isobutyryl-7-hydroxy-N-trityl morpholinoguanosine; N2-isobutyryl-7'-OH-N-trityl morpholino guanosine; N-(9-((2R,6S)-6-(Hydroxymethyl)-4-tritylmorpholin-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide; N-{9-[(2R,6S)-6-(Hydroxymethyl)-4-trityl-2-morpholinyl]-6-oxo-6,9-dihydro-3H-purin-2-yl}-2-methylpropanamide

Related CAS: 722458-03-9 (N-(6-Hydroxy-9-(6-(hydroxymethyl)-4-tritylmorpholin-2-yl)-9H-purin-2-yl) isobutyramide)

5-Me-DMT-2'-O-Me-C(Ac)-CE Phosphoramidite

Description: 5-Me-DMT-2'-O-Me-C(Ac)-CE Phosphoramidite is a specialized nucleotide used in oligonucleotide synthesis. It features a 5-methylcytosine base, a dimethoxytrityl (DMT) protecting group on the 3' hydroxyl, and a 2'-O-methyl modification on the ribose sugar. Additionally, the cytosine base is acetylated (Ac). The 5'-cyanoethyl (CE) phosphoramidite functionality enables controlled addition during synthesis. This compound is used to enhance the stability and modify the properties of synthetic oligonucleotides for various molecular biology research applications, including gene regulation studies and the development of therapeutic nucleic acids.

CAT: BRP-00384

Molecular Formula: C43H54N5O9P

Molecular Weight: 815.90

Purity: ≥98%

Appearance: White to off-white powder

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Storage: Store at -20 °C

InChIKey: OGKXPQMWAXJVBW-KZQAAKLLSA-N

CanonicalSMILES: CC1=CN(C(=O)N=C1NC(=O)C)C2C(C(C(O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OP(N(C(C)C)C(C)C)OCCC#N)OC

IUPAC Name: N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-methoxyoxolan-2-yl]-5-methyl-2-oxopyrimidin-4-yl]acetamide

InChI: InChI=1S/C43H54N5O9P/c1-28(2)48(29(3)4)58(55-25-13-24-44)57-38-37(56-41(39(38)53-9)47-26-30(5)40(45-31(6)49)46-42(47)50)27-54-43(32-14-11-10-12-15-32,33-16-20-35(51-7)21-17-33)34-18-22-36(52-8)23-19-34/h10-12,14-23,26,28-29,37-39,41H,13,25,27H2,1-9H3,(H,45,46,49,50)/t37-,38-,39-,41-,58?/m1/s1

Synonyms: N4-Acetyl-5-methyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-cytidine-3'-cyanoethyl phosphoramidite; 2'-OMe-5-Me-C-CE Phosphoramidite; 5'-Dimethoxytrityl-N-acetyl-5-methyl-Cytidine, 2'-O-methyl, 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; 5-Me-DMT-2'-O-Me-C(Ac)-CE-Phosphoramidite; 5-Me-5'-DMT-2'-O-Me-C(Ac)-CE-Phosphoramidite

5-Me-DMT-2'-O-Me-C(dmf)-CE Phosphoramidite

Description: 5-Me-DMT-2'-O-Me-C(dmf)-CE Phosphoramidite is a specialized nucleotide used in oligonucleotide synthesis. It features a 5-methylcytosine base with a dimethylformamide (dmf) protecting group on the cytosine. The compound includes a dimethoxytrityl (DMT) protecting group on the 3' hydroxyl and a 2'-O-methyl modification on the ribose sugar. The 5'-cyanoethyl (CE) phosphoramidite functionality allows for controlled addition during synthesis. This phosphoramidite is used to create stable and precisely modified oligonucleotides for molecular biology research, including applications in gene regulation and the development of therapeutic nucleic acids.

CAT: BRP-00385

Molecular Formula: C44H57N6O8P

Molecular Weight: 828.95

Purity: ≥98% by HPLC

Appearance: White to off-white powder

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Storage: Store at -20 °C

InChIKey: IFBAEFQLIMLQSD-IROHRKTHSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(4-(((dimethylamino)methylene)amino)-5-methyl-2-oxopyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C44H57N6O8P/c1-30(2)50(31(3)4)59(56-26-14-25-45)58-39-38(57-42(40(39)54-10)49-27-32(5)41(47-43(49)51)46-29-48(6)7)28-55-44(33-15-12-11-13-16-33,34-17-21-36(52-8)22-18-34)35-19-23-37(53-9)24-20-35/h11-13,15-24,27,29-31,38-40,42H,14,26,28H2,1-10H3/t38-,39-,40-,42-,59?/m1/s1

Synonyms: N4-Dimethylformamide-5-methyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-cytidine-3'-cyanoethyl phosphoramidite; 2'-OMe 5-Me-C(dmf) amidite; 2'-OMe MeC(dmf) amidite; N4-dimethylformamidine-5-methyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-cytidine-3'-cyanoethyl Phosphoramidite; 5-Methyl Cytidine (n,n-dmf) 2'-O-Methyl CED phosphoramidite

LNA-5-Me-C(Bz)-CE Phosphoramidite

Description: LNA-5-Me-C(Bz)-CE Phosphoramidite is a specialized nucleotide used in oligonucleotide synthesis. It features a locked nucleic acid (LNA) backbone with a 5-methylcytosine base modified with a benzoyl (Bz) group. Additionally, it includes a 5'-cyanoethyl (CE) phosphoramidite functionality, allowing for controlled addition during synthesis. LNAs are known for their enhanced hybridization properties and stability, making this phosphoramidite useful for applications requiring high-affinity binding and specificity, such as antisense oligonucleotide therapy, SNP detection, and diagnostic assays in molecular biology research.

CAT: BRP-00387

CAS: 206055-82-5

Molecular Formula: C48H54N5O9P

Molecular Weight: 875.96

Purity: ≥95%

Appearance: Off-white to yellow powder

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Storage: Store at -20 °C

InChIKey: XHILZPWJJJDDDY-HXAWEXODSA-N

CanonicalSMILES: CC1=CN(C(=O)N=C1NC(=O)C2=CC=CC=C2)C3C4C(C(O3)(CO4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC)OP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: N-[1-[(1R,3R,4R,7S)-1-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-7-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-2,5-dioxabicyclo[2.2.1]heptan-3-yl]-5-methyl-2-oxopyrimidin-4-yl]benzamide

InChI: InChI=1S/C48H54N5O9P/c1-32(2)53(33(3)4)63(60-28-14-27-49)62-42-41-45(52-29-34(5)43(51-46(52)55)50-44(54)35-15-10-8-11-16-35)61-47(42,30-58-41)31-59-48(36-17-12-9-13-18-36,37-19-23-39(56-6)24-20-37)38-21-25-40(57-7)26-22-38/h8-13,15-26,29,32-33,41-42,45H,14,28,30-31H2,1-7H3,(H,50,51,54,55)/t41-,42+,45-,47-,63?/m1/s1

Synonyms: 5'-O-DMTr-2'-O-4'-C-Locked-5-Me-C(Bz) Phosphoramidite; DMT-locMeC(bz)Amidite; DMT-locMeC(bz) phosphoramidite; N-[1-[2,5-Anhydro-5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-α-L-lyxofuranosyl]-1,2-dihydro-5-methyl-2-oxo-4-pyrimidinyl]benzamide; DMTr-LNA-5MeC(Bz)-3-CED-phosphoramidite; N4-benzoyl-5-methyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-4'-C-Locked-cytidine-3'-cyanoethyl Phosphoramidite; LNA-5MeC(Bz)-3-CED-phosphoramidite; Bz-5-Me-C-LA-CE Phosphoramidite; DMT-2'-O-4'-C-Locked-5-Me-C(Bz)-CE; LNA-5mC(Bz) phosphoramidite; N4-Bz-2'-O-4'-C-Locked-5-Me-Cr-CE-Phosphoramidite

LNA-5-Me-C(Ac)-CE Phosphoramidite

Description: LNA-5-Me-C(Ac)-CE Phosphoramidite is a specialized nucleotide used in oligonucleotide synthesis. It comprises a locked nucleic acid (LNA) backbone with a 5-methylcytosine base modified with an acetyl (Ac) group. Additionally, it contains a 5'-cyanoethyl (CE) phosphoramidite functionality for controlled addition during synthesis. LNAs are known for their enhanced hybridization properties and stability, and the 5-methyl modification further enhances these characteristics. This phosphoramidite is valuable in molecular biology research for applications requiring high specificity and affinity, such as antisense oligonucleotide therapy, SNP detection, and diagnostic assays.

CAT: BRP-00388

Molecular Formula: C43H52N5O9P

Molecular Weight: 813.89

Purity: ≥95%

Appearance: Off-white to yellow powder

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Storage: Store at -20 °C

InChIKey: UUPGQIYQTKJJKS-GKGIDAFMSA-N

CanonicalSMILES: CC1=CN(C(=O)N=C1NC(=O)C)C2C3C(C(O2)(CO3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N(C(C)C)C(C)C)OCCC#N

InChI: InChI=1S/C43H52N5O9P/c1-28(2)48(29(3)4)58(55-24-12-23-44)57-38-37-40(47-25-30(5)39(45-31(6)49)46-41(47)50)56-42(38,26-53-37)27-54-43(32-13-10-9-11-14-32,33-15-19-35(51-7)20-16-33)34-17-21-36(52-8)22-18-34/h9-11,13-22,25,28-29,37-38,40H,12,24,26-27H2,1-8H3,(H,45,46,49,50)/t37-,38+,40-,42-,58?/m1/s1

Synonyms: N6-Acetyl-5-methyl-5'-O-(4,4'-dimethoxytrityl)-LNA-cytidine-3'-cyanoethyl phosphoramidite; 5'-O-DMTr-2'-O-4'-C-Locked-5-Me-C(Ac) Phosphoramidite; DMT-locMeC(Ac)Amidite; DMT-locMeC(Ac) phosphoramidite; DMTr-LNA-5MeC(Ac)-3-CED-phosphoramidite; N6-Acetyl-5-methyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-4'-C-Locked-cytidine-3'-cyanoethyl Phosphoramidite; LNA-5MeC(Ac)-3-CED-phosphoramidite; Ac-5-Me-C-LA-CE Phosphoramidite; DMTr-2'-O-4'-C-Locked-5-Me-rC(Ac)-3'-CE-Phosphoramidite; N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-4'-C-Locked-5-Methyl-Cytidine-3'-cyanoethyl Phosphoramidite; LNA MeC(Ac) amidite

LNA-C(Ac)-CE Phosphoramidite

Description: LNA-C(Ac)-CE Phosphoramidite is a specialized nucleotide used in oligonucleotide synthesis. It features a locked nucleic acid (LNA) backbone with a cytosine base modified with an acetyl (Ac) group. Additionally, it contains a 5'-cyanoethyl (CE) phosphoramidite functionality for controlled addition during synthesis. LNAs are known for their enhanced hybridization properties and stability, and the acetyl modification further enhances these characteristics. This phosphoramidite is valuable in molecular biology research for applications requiring high specificity and affinity, such as antisense oligonucleotide therapy, SNP detection, and diagnostic assays.

CAT: BRP-00389

Molecular Formula: C42H50N5O9P

Molecular Weight: 799.86

Purity: ≥95%

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Storage: Store at -20 °C

InChIKey: VLHUEAKCEPSXIL-WFNFTXKBSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C2C(OC1(CO2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)N6C=CC(=NC6=O)NC(=O)C

InChI: InChI=1S/C42H50N5O9P/c1-28(2)47(29(3)4)57(54-25-11-23-43)56-38-37-39(46-24-22-36(44-30(5)48)45-40(46)49)55-41(38,26-52-37)27-53-42(31-12-9-8-10-13-31,32-14-18-34(50-6)19-15-32)33-16-20-35(51-7)21-17-33/h8-10,12-22,24,28-29,37-39H,11,25-27H2,1-7H3,(H,44,45,48,49)/t37-,38+,39-,41-,57?/m1/s1

Synonyms: N6-Acetyl-5'-O-(4,4'-dimethoxytrityl)-LNA-cytidine-3'-cyanoethyl phosphoramidite; 5'-O-DMTr-2'-O-4'-C-Locked-C(Ac) Phosphoramidite; DMT-locC(Ac)Amidite; DMT-locC(Ac) phosphoramidite; DMTr-LNA-C(Ac)-3-CED-phosphoramidite; N6-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-4'-C-Locked-cytidine-3'-cyanoethyl Phosphoramidite; LNA-C(Ac)-3-CED-phosphoramidite; Ac-C-LA-CE Phosphoramidite; DMTr-2'-O-4'-C-Locked-rC(Ac)-3'-CE-Phosphoramidite; N4-Acetyl-5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-4'-C-Locked-cytidine-3'-CE Phosphoramidite; N4-Ac-2'-O-4'-C-Locked-Cr-CE-Phosphoramidite

LNA-G(dmf)-CE Phosphoramidite

Description: LNA-G(dmf)-CE Phosphoramidite is a specialized nucleotide used in oligonucleotide synthesis. It features a locked nucleic acid (LNA) backbone with a guanine base modified with a dimethylformamide (dmf) group. Additionally, it contains a 5'-cyanoethyl (CE) phosphoramidite functionality for controlled addition during synthesis. LNAs are known for their enhanced hybridization properties and stability, and the dmf modification further enhances these characteristics. This phosphoramidite is valuable in molecular biology research for applications requiring high specificity and affinity, such as antisense oligonucleotide therapy, SNP detection, and diagnostic assays.

CAT: BRP-00390

CAS: 709641-79-2

Molecular Formula: C44H53N8O8P

Molecular Weight: 852.91

Purity: ≥95%

Appearance: Off-white to yellow powder

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InChIKey: ACJXYPZQPQPGNE-KPKUBJDASA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C2C(OC1(CO2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)N6C=NC7=C6N=C(NC7=O)N=CN(C)C

IUPAC Name: N'-[9-[(1R,3R,4R,7S)-1-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-7-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-2,5-dioxabicyclo[2.2.1]heptan-3-yl]-6-oxo-1H-purin-2-yl]-N,N-dimethylmethanimidamide

InChI: InChI=1S/C44H53N8O8P/c1-29(2)52(30(3)4)61(58-24-12-23-45)60-38-37-41(51-28-46-36-39(51)48-42(49-40(36)53)47-27-50(5)6)59-43(38,25-56-37)26-57-44(31-13-10-9-11-14-31,32-15-19-34(54-7)20-16-32)33-17-21-35(55-8)22-18-33/h9-11,13-22,27-30,37-38,41H,12,24-26H2,1-8H3,(H,48,49,53)/t37-,38+,41-,43-,61?/m1/s1

Synonyms: 2'-O-4'-C-Locked-rG(dmf) Phosphoramidite; 5'-Dimethoxytrityl-N-dimethylformamidine-(2'-O,4'-C-methylene)-Guanosine, 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; dmf-G-LA-CE Phosphoramidite; 5'-DMT-LNA-Guanosine(N-dmf) CE Phosphoramidite; DMTr-2'-O-4'-C-Locked-rG(dmf)-3'-CE-Phosphoramidite; N'-[9-[2,5-Anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-α-L-lyxofuranosyl]-6,9-dihydro-6-oxo-1H-purin-2-yl]-N,N-dimethylmethanimidamide; DMT-2'-O-4'-C-Locked-G(dmf)-CE; LNA-G(dmf) phosphoramidite; N2-Dimethylformamidine-5'-O-(4,4'-dimethoxytrityl)-2'-O-4'-C-Locked-Guanosine-3'-cyanoethyl Phosphoramidite; N2-dmf-2'-O-4'-C-Locked-Gr-CE-Phosphoramidite

LNA-U-CE Phosphoramidite

Description: LNA-U-CE Phosphoramidite is a specialized nucleotide used in oligonucleotide synthesis. It comprises a locked nucleic acid (LNA) backbone with a uracil base and includes a 5'-cyanoethyl (CE) phosphoramidite functionality for controlled addition during synthesis. LNAs are known for their enhanced stability and affinity for complementary sequences, making them valuable in molecular biology research for applications such as antisense oligonucleotide therapy, SNP detection, and diagnostic assays. This phosphoramidite variant specifically provides increased stability and specificity in oligonucleotide design, contributing to more effective molecular tools for diverse research needs.

CAT: BRP-00391

CAS: 206055-76-7

Molecular Formula: C40H47N4O9P

Molecular Weight: 758.81

Purity: ≥95%

Appearance: White to off-white solid

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Storage: Store at 2-8 °C, stored under nitrogen

InChIKey: ROCIJWWVBQZMMI-PUIMFIDCSA-N

Solubility: Soluble in DMSO

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C2C(OC1(CO2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)N6C=CC(=O)NC6=O

IUPAC Name: 3-[[(1R,3R,4R,7S)-1-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-(2,4-dioxopyrimidin-1-yl)-2,5-dioxabicyclo[2.2.1]heptan-7-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C40H47N4O9P/c1-27(2)44(28(3)4)54(51-24-10-22-41)53-36-35-37(43-23-21-34(45)42-38(43)46)52-39(36,25-49-35)26-50-40(29-11-8-7-9-12-29,30-13-17-32(47-5)18-14-30)31-15-19-33(48-6)20-16-31/h7-9,11-21,23,27-28,35-37H,10,24-26H2,1-6H3,(H,42,45,46)/t35-,36+,37-,39-,54?/m1/s1

Synonyms: DMTr-LNA-U-3-CED-phosphoramidite; 1-[2,5-Anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-α-L-lyxofuranosyl]-2,4(1H,3H)-pyrimidinedione; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O,4'-C-methylene-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; DMTr-2'-O-4'-C-Locked-rU-3'-CE-Phosphoramidite; 5'-O-DMTr-2'-O,4'-C-methyleneuridine 3'-CE-phosphoramidite; 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-4'-C-Locked-uridine-3'-CE Phosphoramidite; 2'-O-4'-C-Locked-Ur-CE-Phosphoramidite

DMTr-LNA-5MeU-3-CED-phosphoramidite

Description: DMTr-LNA-5MeU-3'-CED-phosphoramidite is a chemically modified nucleotide used in oligonucleotide synthesis. It features a 5-methyluridine (5MeU) base incorporated into a locked nucleic acid (LNA) structure, with a DMTr (dimethoxytrityl) protecting group at the 5' position and a CED (cyanoethyl diisopropylamino) phosphoramidite group at the 3' position. This modification enhances the binding affinity and stability of the synthesized oligonucleotides, making it valuable for advanced research in molecular biology, genetics, and the development of therapeutic nucleic acids.

CAT: BRP-00393

CAS: 206055-75-6

Molecular Formula: C41H49N4O9P

Molecular Weight: 772.84

Purity: ≥95%

Appearance: White to off-white solid

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Storage: Store at 2-8 °C, protect from light

InChIKey: STPXOEPMLLHUDQ-ZRCIEBSPSA-N

Solubility: Soluble in DMSO

CanonicalSMILES: CC1=CN(C(=O)NC1=O)C2C3C(C(O2)(CO3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: 3-[[(1R,3R,4R,7S)-1-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-(5-methyl-2,4-dioxopyrimidin-1-yl)-2,5-dioxabicyclo[2.2.1]heptan-7-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C41H49N4O9P/c1-27(2)45(28(3)4)55(52-23-11-22-42)54-36-35-38(44-24-29(5)37(46)43-39(44)47)53-40(36,25-50-35)26-51-41(30-12-9-8-10-13-30,31-14-18-33(48-6)19-15-31)32-16-20-34(49-7)21-17-32/h8-10,12-21,24,27-28,35-36,38H,11,23,25-26H2,1-7H3,(H,43,46,47)/t35-,36+,38-,40-,55?/m1/s1

Synonyms: 1-[2,5-Anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-α-L-lyxofuranosyl]-5-methyl-2,4(1H,3H)-pyrimidinedione; (1R,3R,4R,7S)-1-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,5-dioxabicyclo[2.2.1]heptan-7-yl (2-cyanoethyl) diisopropylphosphoramidite; 5'-O-(4,4'-Dimethoxytrityl)-LNA-thymidine-3'-cyanoethyl phosphoramidite; 5'-O-(4,4'-dimethoxytrityl)-2'-O-4'-C-Locked-thymidine-3'-cyanoethyl Phosphoramidite; 2'-O-4'-C-Locked-Tr-CE-Phosphoramidite

DMTr-LNA-A(Bz)-3-CED-phosphoramidite

Description: DMTr-LNA-A(Bz)-3'-CED-phosphoramidite is a chemically modified nucleotide used in the synthesis of oligonucleotides. It features an adenine base (A) with a benzoyl (Bz) protecting group, incorporated into a locked nucleic acid (LNA) structure. The nucleotide has a dimethoxytrityl (DMTr) protecting group at the 5' position and a cyanoethyl diisopropylamino (CED) phosphoramidite group at the 3' position. This modification enhances the stability and binding affinity of oligonucleotides, making it useful for advanced genetic and molecular biology research, as well as for the development of therapeutic nucleic acids. It can be used for the synthesis of ASOs (antisense oligonucleotides).

CAT: BRP-00394

CAS: 206055-79-0

Molecular Formula: C48H52N7O8P

Molecular Weight: 885.96

Purity: ≥95%

Appearance: White to off-white solid

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InChIKey: HPIDKMAOZZZGOP-LIUGLABVSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C2C(OC1(CO2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)N6C=NC7=C(N=CN=C76)NC(=O)C8=CC=CC=C8

IUPAC Name: N-[9-[(1R,3R,4R,7S)-1-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-7-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-2,5-dioxabicyclo[2.2.1]heptan-3-yl]purin-6-yl]benzamide

InChI: InChI=1S/C48H52N7O8P/c1-32(2)55(33(3)4)64(61-27-13-26-49)63-42-41-46(54-31-52-40-43(50-30-51-44(40)54)53-45(56)34-14-9-7-10-15-34)62-47(42,28-59-41)29-60-48(35-16-11-8-12-17-35,36-18-22-38(57-5)23-19-36)37-20-24-39(58-6)25-21-37/h7-12,14-25,30-33,41-42,46H,13,27-29H2,1-6H3,(H,50,51,53,56)/t41-,42+,46-,47-,64?/m1/s1

Synonyms: N-[9-[2,5-Anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-α-L-lyxofuranosyl]-9H-purin-6-yl]benzamide; N6-Bz-2'-O-4'-A-Locked-Ar-CE-Phosphoramidite; DMT-locA(bz)Amidite; LNA-A(Bz) amidite; N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-4'-C-Locked-adenosine-3'-cyanoethyl Phosphoramidite; N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-LNA-adenosine-3'-cyanoethyl phosphoramidite; LNA-A(Bz)-CE Phosphoramidite; Bz-A-LA-CE Phosphoramidite

6-ROX-Phosphoramidite

Description: 6-ROX-Phosphoramidite is a fluorescent dye phosphoramidite used in the synthesis of labeled oligonucleotides. The 6-ROX (6-carboxy-X-rhodamine) dye is known for its strong fluorescence and is often used in molecular biology applications, such as real-time PCR, DNA sequencing, and fluorescence in situ hybridization (FISH). Incorporating 6-ROX into oligonucleotides allows for the visualization and tracking of nucleic acids in various research and diagnostic applications.

CAT: BRP-00400

Molecular Formula: C48H60N5O6P

Molecular Weight: 834.01

Purity: ≥97%

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InChIKey: OVEHZTATEJWCCS-UHFFFAOYSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCCCCCNC(=O)C1=CC(=C(C=C1)C(=O)[O-])C2=C3C=C4CCC[N+]5=C4C(=C3OC6=C2C=C7CCCN8C7=C6CCC8)CCC5)OCCC#N

IUPAC Name: 4-[6-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyhexylcarbamoyl]-2-(3-oxa-23-aza-9-azoniaheptacyclo[17.7.1.15,9.02,17.04,15.023,27.013,28]octacosa-1(27),2(17),4,9(28),13,15,18-heptaen-16-yl)benzoate

InChI: InChI=1S/C48H60N5O6P/c1-31(2)53(32(3)4)60(58-27-13-20-49)57-26-8-6-5-7-21-50-47(54)35-18-19-36(48(55)56)39(30-35)42-40-28-33-14-9-22-51-24-11-16-37(43(33)51)45(40)59-46-38-17-12-25-52-23-10-15-34(44(38)52)29-41(42)46/h18-19,28-32H,5-17,21-27H2,1-4H3,(H-,50,54,55,56)

Synonyms: 6-ROX Phosphoramidite

DMT-2'-O-TBDMS-G(dmf)-CE Phosphoramidite

Description: DMT-2'-O-TBDMS-G(dmf)-CE Phosphoramidite is a specialized nucleotide used in oligonucleotide synthesis. It features a dimethoxytrityl (DMT) protecting group on the 3' hydroxyl, a tert-butyldimethylsilyl (TBDMS) protecting group on the 2' hydroxyl, and a guanine base modified with a dimethylformamide (dmf) group. Additionally, it contains a 5'-cyanoethyl (CE) phosphoramidite functionality for controlled addition during synthesis. This compound enables stable and precise synthesis of oligonucleotides for various molecular biology research applications, including gene silencing, antisense therapy, and diagnostics.

CAT: BRP-00402

CAS: 149559-87-5

Molecular Formula: C49H67N8O8PSi

Molecular Weight: 955.18

Purity: ≥95%

Appearance: White to light yellow powder

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InChIKey: RQXRLANMGPTUJP-UTESLAMRSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=NC3=C2N=C(NC3=O)N=CN(C)C)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: N'-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]-N,N-dimethylmethanimidamide

InChI: InChI=1S/C49H67N8O8PSi/c1-33(2)57(34(3)4)66(62-29-17-28-50)64-42-40(30-61-49(35-18-15-14-16-19-35,36-20-24-38(59-10)25-21-36)37-22-26-39(60-11)27-23-37)63-46(43(42)65-67(12,13)48(5,6)7)56-32-51-41-44(56)53-47(54-45(41)58)52-31-55(8)9/h14-16,18-27,31-34,40,42-43,46H,17,29-30H2,1-13H3,(H,53,54,58)/t40-,42-,43-,46-,66?/m1/s1

Synonyms: Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N-[(dimethylamino)methylene]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; N2-Dimethylformamidine-5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyl-dimethylsilyl)-guanosine-3'-cyanoethyl Phosphoramidite; 5'-O-DMT-2'-O-TBDMS-N2-DMF-Guanosine 3'-CE phosphoramidite; rG (dmf) CE-Phosphoramidite

5'-DMT-2'-OMe-A(Bz)-3'-PS-Phosphoramidite

Description: 5'-DMT-2'-OMe-A(Bz)-3'-PS-Phosphoramidite is a specialized nucleotide compound utilized in oligonucleotide synthesis. It features a dimethoxytrityl (DMT) protecting group at the 5' position, a 2'-O-methyl modification on the ribose sugar, and an adenine base modified with a benzoyl (Bz) group. Additionally, it incorporates a phosphorothioate (PS) linkage at the 3' position. This phosphoramidite enables controlled addition during synthesis and offers enhanced stability and resistance to nuclease degradation in oligonucleotide sequences. It finds applications in molecular biology research, including gene synthesis, RNA interference, and nucleic acid probe development.

CAT: BRP-00403

Molecular Formula: C52H53N6O8PS2

Molecular Weight: 985.12

Purity: ≥98% by HPLC

Appearance: White to off-white powder

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InChIKey: CLDYJLPUISOESS-LTMMGAFGSA-N

CanonicalSMILES: COC1C(C(OC1N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC)OP(N8CCCC8)SCCSC(=O)C9=CC=CC=C9

IUPAC Name: S-[2-[[(2R,3R,4R,5R)-5-(6-benzamidopurin-9-yl)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-methoxyoxolan-3-yl]oxy-pyrrolidin-1-ylphosphanyl]sulfanylethyl] benzenecarbothioate

InChI: InChI=1S/C52H53N6O8PS2/c1-61-41-25-21-39(22-26-41)52(38-19-11-6-12-20-38,40-23-27-42(62-2)28-24-40)64-33-43-45(66-67(57-29-13-14-30-57)69-32-31-68-51(60)37-17-9-5-10-18-37)46(63-3)50(65-43)58-35-55-44-47(53-34-54-48(44)58)56-49(59)36-15-7-4-8-16-36/h4-12,15-28,34-35,43,45-46,50H,13-14,29-33H2,1-3H3,(H,53,54,56,59)/t43-,45-,46-,50-,67?/m1/s1

Synonyms: S-(2-(((((2R,3R,4R,5R)-5-(6-Benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl)oxy)(pyrrolidin-1-yl)phosphino)thio)ethyl) benzothioate; DMT-2'-OMe-A(Bz)-3'-PS; [N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-adenosine]-3'-[S-(β-(Benzoylmercapto)ethyl) Pyrrolidino Thiophosphoroamidite]; 2'-OMe-A-Thiophosphoramidite; 5'-Dimethoxytrityl-N-benzoyl-Adenosine, 2'-O-methyl, 3'-[(β-thiobenzoylethyl)-(1-pyrrolidinyl)]-thiophosphoramidite

5'-DMT-2'-OMe-G(iBu)-3'-PS-Phosphoramidite

Description: 5'-DMT-2'-OMe-G(iBu)-3'-PS-Phosphoramidite is a specialized nucleotide compound employed in oligonucleotide synthesis. It features a dimethoxytrityl (DMT) protecting group at the 5' position, a 2'-O-methyl modification on the ribose sugar, and a guanine base modified with an isobutyl (iBu) group. Additionally, it incorporates a phosphorothioate (PS) linkage at the 3' position. This phosphoramidite enables controlled addition during synthesis and offers enhanced stability and resistance to nuclease degradation in oligonucleotide sequences. It finds applications in molecular biology research, including gene synthesis, RNA interference, and nucleic acid probe development.

CAT: BRP-00404

Molecular Formula: C49H55N6O9PS2

Molecular Weight: 967.11

Purity: ≥90% by HPLC

Appearance: White to yellow powder

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InChIKey: HZMNPGZRUUSWOU-VKFKYRIUSA-N

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N7CCCC7)SCCSC(=O)C8=CC=CC=C8)OC

IUPAC Name: S-[2-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-methoxy-5-[2-(2-methylpropanoylamino)-6-oxo-1H-purin-9-yl]oxolan-3-yl]oxy-pyrrolidin-1-ylphosphanyl]sulfanylethyl] benzenecarbothioate

InChI: InChI=1S/C49H55N6O9PS2/c1-32(2)44(56)52-48-51-43-40(45(57)53-48)50-31-55(43)46-42(61-5)41(64-65(54-26-12-13-27-54)67-29-28-66-47(58)33-14-8-6-9-15-33)39(63-46)30-62-49(34-16-10-7-11-17-34,35-18-22-37(59-3)23-19-35)36-20-24-38(60-4)25-21-36/h6-11,14-25,31-32,39,41-42,46H,12-13,26-30H2,1-5H3,(H2,51,52,53,56,57)/t39-,41-,42-,46-,65?/m1/s1

Synonyms: DMT-2'-OMe-G(iBu)-3'-PS; [N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-guanosine]-3'-[S-(β-(Benzoylmercapto)ethyl)pyrrolidino Thiophosphoroamidite]; S-(2-(((((2R,3R,4R,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1H-purin-9(6H)-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(pyrrolidin-1-yl)phosphino)thio)ethyl) benzothioate; 2'-OMe-G-Thiophosphoramidite; 5'-Dimethoxytrityl-N-isobutyryl-Guanosine, 2'-O-methyl,3'-[(β-thiobenzoylethyl)-(1-pyrrolidinyl)]-thiophosphoramidite

5'-DMT-2'-O-MOE-G(iBu)-3'-PS-Phosphoramidite

Description: 5'-DMT-2'-O-MOE-G(iBu)-3'-PS-Phosphoramidite is a specialized nucleotide used in oligonucleotide synthesis. It features a dimethoxytrityl (DMT) protecting group at the 5' position, a 2'-O-methoxyethyl (MOE) modification on the ribose sugar, and a guanine base modified with an isobutyl (iBu) group. Additionally, it incorporates a phosphorothioate (PS) linkage at the 3' position. This phosphoramidite facilitates controlled addition during synthesis and provides enhanced stability and resistance to nuclease degradation in oligonucleotide sequences. It is utilized in various molecular biology research applications, including gene synthesis, RNA interference, and nucleic acid probe development.

CAT: BRP-00405

CAS: 2360826-78-2

Molecular Formula: C51H59N6O10PS2

Molecular Weight: 1011.16

Purity: ≥90% by HPLC

Appearance: White to yellow powder

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InChIKey: HDXVTGDRJQVYMX-MGIZDRFQSA-N

CanonicalSMILES: O=C1N=C(NC(=O)C(C)C)NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP(SCCSC(=O)C=7C=CC=CC7)N8CCCC8)C3OCCOC

IUPAC Name: S-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl)oxy)(pyrrolidin-1-yl)phosphaneyl)thio)ethyl) benzothioate

InChI: InChI=1S/C51H59N6O10PS2/c1-34(2)46(58)54-50-53-45-42(47(59)55-50)52-33-57(45)48-44(64-29-28-61-3)43(67-68(56-26-12-13-27-56)70-31-30-69-49(60)35-14-8-6-9-15-35)41(66-48)32-65-51(36-16-10-7-11-17-36,37-18-22-39(62-4)23-19-37)38-20-24-40(63-5)25-21-38/h6-11,14-25,33-34,41,43-44,48H,12-13,26-32H2,1-5H3,(H2,53,54,55,58,59)/t41-,43-,44-,48-,68?/m1/s1

Synonyms: [N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methoxyethyl-guanosine]-3'-[S-(β-(Benzoylmercapto)ethyl) Pyrrolidino Thiophosphoroamidite]

5'-DMT-2'-O-MOE-A(Bz)-3'-PS-Phosphoramidite

Description: 5'-DMT-2'-O-MOE-A(Bz)-3'-PS-Phosphoramidite is a specialized nucleotide compound utilized in oligonucleotide synthesis. It features a dimethoxytrityl (DMT) protecting group at the 5' position, a 2'-O-methoxyethyl (MOE) modification on the ribose sugar, and an adenine base modified with a benzoyl (Bz) group. Additionally, it incorporates a phosphorothioate (PS) linkage at the 3' position. This phosphoramidite enables controlled addition during synthesis and offers enhanced stability and resistance to nuclease degradation in oligonucleotide sequences. It finds applications in molecular biology research, including gene synthesis, RNA interference, and nucleic acid probe development.

CAT: BRP-00406

CAS: 2360826-72-6

Molecular Formula: C54H57N6O9PS2

Molecular Weight: 1029.18

Purity: ≥90% by HPLC

Appearance: White to yellow powder

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InChIKey: OKYFNXWXBWXJHI-QRWWDSLFSA-N

CanonicalSMILES: O=C(SCCSP(OC1C(OC(N2C=NC=3C(=NC=NC32)NC(=O)C=4C=CC=CC4)C1OCCOC)COC(C=5C=CC=CC5)(C6=CC=C(OC)C=C6)C7=CC=C(OC)C=C7)N8CCCC8)C=9C=CC=CC9

IUPAC Name: S-(2-(((((2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl)oxy)(pyrrolidin-1-yl)phosphaneyl)thio)ethyl) benzothioate

InChI: InChI=1S/C54H57N6O9PS2/c1-63-31-32-66-48-47(69-70(59-29-13-14-30-59)72-34-33-71-53(62)39-17-9-5-10-18-39)45(68-52(48)60-37-57-46-49(55-36-56-50(46)60)58-51(61)38-15-7-4-8-16-38)35-67-54(40-19-11-6-12-20-40,41-21-25-43(64-2)26-22-41)42-23-27-44(65-3)28-24-42/h4-12,15-28,36-37,45,47-48,52H,13-14,29-35H2,1-3H3,(H,55,56,58,61)/t45-,47-,48-,52-,70?/m1/s1

Synonyms: [N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methoxyethyl-adenosine]-3'-[S-(β-(Benzoylmercapto)ethyl) Pyrrolidino Thiophosphoroamidite]

5'-DMT-2'-O-MOE-5-Me-C(Bz)-3'-PS-Phosphoramidite

Description: 5'-DMT-2'-O-MOE-5-Me-C(Bz)-3'-PS-Phosphoramidite is a specialized nucleotide used in oligonucleotide synthesis. It features a dimethoxytrityl (DMT) protecting group at the 5' position, a 2'-O-methoxyethyl (MOE) modification on the ribose sugar, and a 5-methylcytosine base modified with a benzoyl (Bz) group. Additionally, it incorporates a phosphorothioate (PS) linkage at the 3' position. This phosphoramidite enables controlled addition during synthesis and provides enhanced stability and resistance to nuclease degradation in oligonucleotide sequences. It is utilized in various molecular biology research applications, including gene synthesis, RNA interference, and nucleic acid probe development.

CAT: BRP-00407

CAS: 2360826-74-8

Molecular Formula: C54H59N4O10PS2

Molecular Weight: 1019.18

Purity: ≥90% by HPLC

Appearance: White to yellow powder

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InChIKey: JHTAVHWNDBSHFT-GDWCHFCQSA-N

CanonicalSMILES: O=C1N=C(NC(=O)C=2C=CC=CC2)C(=CN1C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP(SCCSC(=O)C=7C=CC=CC7)N8CCCC8)C3OCCOC)C

IUPAC Name: S-(2-(((((2R,3R,4R,5R)-5-(4-benzamido-5-methyl-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl)oxy)(pyrrolidin-1-yl)phosphaneyl)thio)ethyl) benzothioate

InChI: InChI=1S/C54H59N4O10PS2/c1-38-36-58(53(61)56-49(38)55-50(59)39-16-8-5-9-17-39)51-48(65-33-32-62-2)47(68-69(57-30-14-15-31-57)71-35-34-70-52(60)40-18-10-6-11-19-40)46(67-51)37-66-54(41-20-12-7-13-21-41,42-22-26-44(63-3)27-23-42)43-24-28-45(64-4)29-25-43/h5-13,16-29,36,46-48,51H,14-15,30-35,37H2,1-4H3,(H,55,56,59,61)/t46-,47-,48-,51-,69?/m1/s1

Synonyms: [N4-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methoxyethyl-5-methyl-cytidine]-3'-[S-(β-(Benzoylmercapto)ethyl) Pyrrolidino Thiophosphoroamidite]

5'-DMT-2'-OMe-5-Me-C(Bz)-3'-PS-Phosphoramidite

Description: 5'-DMT-2'-OMe-5-Me-C(Bz)-3'-PS-Phosphoramidite is a specialized nucleotide used in oligonucleotide synthesis. It consists of a dimethoxytrityl (DMT) protecting group at the 5' position, a 2'-O-methyl modification on the ribose sugar, and a 5-methylcytosine base modified with a benzoyl (Bz) group. Additionally, it features a phosphorothioate (PS) linkage at the 3' position. This phosphoramidite facilitates controlled addition during synthesis and enhances stability, making it suitable for applications such as gene synthesis, RNA interference, and nucleic acid probe development in molecular biology research.

CAT: BRP-00408

Molecular Formula: C52H55N4O9PS2

Molecular Weight: 975.12

Purity: ≥90% by HPLC

Appearance: White to yellow powder

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InChIKey: DOVLPDMECIOKGA-BZPNBFHRSA-N

CanonicalSMILES: CC1=CN(C(=O)N=C1NC(=O)C2=CC=CC=C2)C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N7CCCC7)SCCSC(=O)C8=CC=CC=C8)OC

IUPAC Name: S-[2-[[(2R,3R,4R,5R)-5-(4-benzamido-5-methyl-2-oxopyrimidin-1-yl)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-methoxyoxolan-3-yl]oxy-pyrrolidin-1-ylphosphanyl]sulfanylethyl] benzenecarbothioate

InChI: InChI=1S/C52H55N4O9PS2/c1-36-34-56(51(59)54-47(36)53-48(57)37-16-8-5-9-17-37)49-46(62-4)45(65-66(55-30-14-15-31-55)68-33-32-67-50(58)38-18-10-6-11-19-38)44(64-49)35-63-52(39-20-12-7-13-21-39,40-22-26-42(60-2)27-23-40)41-24-28-43(61-3)29-25-41/h5-13,16-29,34,44-46,49H,14-15,30-33,35H2,1-4H3,(H,53,54,57,59)/t44-,45-,46-,49-,66?/m1/s1

Synonyms: [N4-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-5-methyl-cytidine]-3'-[S-(β-(Benzoylmercapto)ethyl) Pyrrolidino Thiophosphoroamidite]; S-(2-(((((2R,3R,4R,5R)-5-(4-Benzamido-5-methyl-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl)oxy)(pyrrolidin-1-yl)phosphino)thio)ethyl) benzothioate

5'-DMT-2'-OMe-C(Ac)-3'-PS-Phosphoramidite

Description: 5'-DMT-2'-OMe-C(Ac)-3'-PS-Phosphoramidite is a specialized nucleotide compound utilized in oligonucleotide synthesis. It features a dimethoxytrityl (DMT) protecting group at the 5' position, a 2'-O-methyl modification on the ribose sugar, and a cytidine base modified with an acetyl (Ac) group. Additionally, it incorporates a phosphorothioate (PS) linkage at the 3' position. This phosphoramidite enables controlled addition during synthesis and provides enhanced stability and resistance to nuclease degradation in oligonucleotide sequences. It is employed in various molecular biology research applications, including gene synthesis, RNA interference, and nucleic acid probe development.

CAT: BRP-00409

Molecular Formula: C46H51N4O9PS2

Molecular Weight: 899.03

Purity: ≥90% by HPLC

Appearance: White to yellow powder

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Storage: Store at -20 °C

InChIKey: CNCXGATYHORASL-SRYSXPHVSA-N

CanonicalSMILES: CC(=O)NC1=NC(=O)N(C=C1)C2C(C(C(O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OP(N6CCCC6)SCCSC(=O)C7=CC=CC=C7)OC

IUPAC Name: S-[2-[[(2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1-yl)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-methoxyoxolan-3-yl]oxy-pyrrolidin-1-ylphosphanyl]sulfanylethyl] benzenecarbothioate

InChI: InChI=1S/C46H51N4O9PS2/c1-32(51)47-40-25-28-50(45(53)48-40)43-42(56-4)41(59-60(49-26-11-12-27-49)62-30-29-61-44(52)33-13-7-5-8-14-33)39(58-43)31-57-46(34-15-9-6-10-16-34,35-17-21-37(54-2)22-18-35)36-19-23-38(55-3)24-20-36/h5-10,13-25,28,39,41-43H,11-12,26-27,29-31H2,1-4H3,(H,47,48,51,53)/t39-,41-,42-,43-,60?/m1/s1

Synonyms: DMT-2'-OMe-C(Ac)-3'-PS; [N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-5-methyl-cytidine]-3'-[S-(β-(Benzoylmercapto)ethyl) Pyrrolidino Thiophosphoroamidite]; S-(2-(((((2R,3R,4R,5R)-5-(4-Acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl)oxy)(pyrrolidin-1-yl)phosphino)thio)ethyl) benzothioate; 2'-OMe-C-Thiophosphoramidite; 5'-Dimethoxytrityl-N-acetyl-Cytidine, 2'-O-methyl,3'-[(β-thiobenzoylethyl)-(1-pyrrolidinyl)]-thiophosphoramidite

5'-DMT-2'-OMe-U-3'-PS-Phosphoramidite

Description: 5'-DMT-2'-OMe-U-3'-PS-Phosphoramidite is a specialized nucleotide used in oligonucleotide synthesis. It comprises a dimethoxytrityl (DMT) protecting group at the 5' position, a 2'-O-methyl modification on the ribose sugar, and a uridine base. Additionally, it contains a phosphorothioate (PS) linkage at the 3' position. This phosphoramidite facilitates controlled addition during synthesis and enhances stability, making it suitable for various applications in molecular biology research, including gene synthesis, RNA interference, and nucleic acid probe development.

CAT: BRP-00410

Molecular Formula: C44H48N3O9PS2

Molecular Weight: 857.97

Purity: ≥90% by HPLC

Appearance: White to yellow powder

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InChIKey: WOJBALAHZBVIKR-QBLJBMGASA-N

CanonicalSMILES: COC1C(C(OC1N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OP(N6CCCC6)SCCSC(=O)C7=CC=CC=C7

IUPAC Name: S-[2-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(2,4-dioxopyrimidin-1-yl)-4-methoxyoxolan-3-yl]oxy-pyrrolidin-1-ylphosphanyl]sulfanylethyl] benzenecarbothioate

InChI: InChI=1S/C44H48N3O9PS2/c1-51-35-20-16-33(17-21-35)44(32-14-8-5-9-15-32,34-18-22-36(52-2)23-19-34)54-30-37-39(40(53-3)41(55-37)47-27-24-38(48)45-43(47)50)56-57(46-25-10-11-26-46)59-29-28-58-42(49)31-12-6-4-7-13-31/h4-9,12-24,27,37,39-41H,10-11,25-26,28-30H2,1-3H3,(H,45,48,50)/t37-,39-,40-,41-,57?/m1/s1

Synonyms: DMT-2'-OMe-U-3'-PS; [5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-uridine]-3'-[S-(β-(Benzoylmercapto)ethyl)Pyrrolidino Thiophosphoroamidite]; S-(2-(((((2R,3R,4R,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(pyrrolidin-1-yl)phosphino)thio)ethyl) benzothioate; 2'-OMe-U-Thiophosphoramidite; 5'-Dimethoxytrityl-Uridine, 2'-O-methyl, 3'-[(β-thiobenzoylethyl)-(1-pyrrolidinyl)]-thiophosphoramidite

N2-Isobutyryl-N-trityl-morpholinoguanosine

5-Me-DMT-2'-O-Me-C(Ac)-CE Phosphoramidite

5-Me-DMT-2'-O-Me-C(dmf)-CE Phosphoramidite

LNA-5-Me-C(Bz)-CE Phosphoramidite

LNA-5-Me-C(Ac)-CE Phosphoramidite

LNA-C(Ac)-CE Phosphoramidite

LNA-G(dmf)-CE Phosphoramidite

LNA-U-CE Phosphoramidite

DMTr-LNA-5MeU-3-CED-phosphoramidite

DMTr-LNA-A(Bz)-3-CED-phosphoramidite

6-ROX-Phosphoramidite

DMT-2'-O-TBDMS-G(dmf)-CE Phosphoramidite

5'-DMT-2'-OMe-A(Bz)-3'-PS-Phosphoramidite

5'-DMT-2'-OMe-G(iBu)-3'-PS-Phosphoramidite

5'-DMT-2'-O-MOE-G(iBu)-3'-PS-Phosphoramidite

5'-DMT-2'-O-MOE-A(Bz)-3'-PS-Phosphoramidite

5'-DMT-2'-O-MOE-5-Me-C(Bz)-3'-PS-Phosphoramidite

5'-DMT-2'-OMe-5-Me-C(Bz)-3'-PS-Phosphoramidite

5'-DMT-2'-OMe-C(Ac)-3'-PS-Phosphoramidite

5'-DMT-2'-OMe-U-3'-PS-Phosphoramidite

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