Description: mmu- or hsa-miR-34a-5p antagomir is a chemically synthesized, single-stranded antisense oligonucleotide designed to specifically bind and inhibit the activity of the mature miR-34a-5p microRNA in mouse (mmu) or human (hsa), respectively. It typically incorporates chemical modifications such as 2'-O-methyl (2'-OMe) or 2'-O-methoxyethyl (2'-MOE) ribose, phosphorothioate backbone linkages, and sometimes cholesterol conjugation to enhance nuclease resistance, increase binding affinity to the target microRNA, and improve cellular uptake. By sequestering miR-34a-5p, the antagomir prevents it from binding to its mRNA targets, leading to derepression of genes normally downregulated by miR-34a-5p, which is often involved in pathways regulating cell cycle arrest, apoptosis, and tumor suppression. Such antagomirs are widely used in functional studies of miRNA biology in vitro and in vivo, and may have potential therapeutic applications in conditions where miR-34a-5p is pathologically overexpressed, such as certain cancers, fibrosis, and cardiovascular diseases.
CAT: B181443R1
Molecular Weight: 7355.85
Appearance: White to off-white solid
