Phosphoramidites

2'-OMe-dmf-G-CE Phosphoramidite

Description: 2'-OMe-dmf-G-CE Phosphoramidite, a vital compound in the biomedicine industry, is leveraged for the crucial synthesis of oligonucleotides. These tiny yet potent molecules are widely utilized in treating an array of afflictions such as cancer, viral infections, and genetic disorders. Devised to heighten the steadfastness and efficacy of oligonucleotides, our product offers patients the potential for better therapeutic outcomes.

CAT: BRP-00014

CAS: 128219-77-2

Molecular Formula: C44H55N8O8P

Molecular Weight: 854.92

Purity: ≥95%

Appearance: white powder

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InChIKey: ZGDBCILCTOHNAB-NANSYJOBSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OC)N2C=NC3=C2N=C(NC3=O)N=CN(C)C)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: N'-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-methoxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]-N,N-dimethylmethanimidamide

InChI: InChI=1S/C44H55N8O8P/c1-29(2)52(30(3)4)61(58-25-13-24-45)60-38-36(59-42(39(38)56-9)51-28-46-37-40(51)48-43(49-41(37)53)47-27-50(5)6)26-57-44(31-14-11-10-12-15-31,32-16-20-34(54-7)21-17-32)33-18-22-35(55-8)23-19-33/h10-12,14-23,27-30,36,38-39,42H,13,25-26H2,1-9H3,(H,48,49,53)/b47-27+/t36-,38-,39-,42-,61?/m1/s1

Synonyms: 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-N-[(dimethylamino)methylene]-2'-O-methylguanosine 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; DMT-2'-O-Me-G(dmf)-CE Phosphoramidite; Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N-[(dimethylamino)methylene]-2'-O-methyl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; 2'-OMe-G-CE Phosphoramidite; 2'-O-Methyl Guanosine (n,n-dmf) CED phosphoramidite

5'-O-DMT-2'-deoxyuridine-3'-CE Phosphoramidite

Description: 5'-O-DMT-2'-deoxyuridine-3'-CE Phosphoramidite stands as an indispensable entity within the realm of biomedicine, wherein its applications for the synthesis of nucleic acids in investigative capacities hold paramount significance. DNA and RNA oligonucleotides rely on this product as their cornerstone, as it seamlessly integrates 2'-deoxyuridine into nucleic acid sequences with exacting efficiency. Aiding the progression of pharmaceutical innovation, gene therapy, and genetic exploration, it emerges as an invaluable instrument that propels advancements in the remediation of diverse medical afflictions.

CAT: BRP-00117

CAS: 109389-30-2

Molecular Formula: C39H47N4O8P

Molecular Weight: 730.80

Purity: ≥95%

Appearance: White to off-white powder

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10 g	$439	In stock

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Storage: Store at 2-8°C

InChIKey: ZGJUDTLSWZPIDW-MVFNBKNKSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1CC(OC1COC(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)C4=CC=C(C=C4)OC)N5C=CC(=O)NC5=O

IUPAC Name: 3-[[(2R,3S,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C39H47N4O8P/c1-27(2)43(28(3)4)52(49-24-10-22-40)51-34-25-37(42-23-21-36(44)41-38(42)45)50-35(34)26-48-39(29-11-8-7-9-12-29,30-13-17-32(46-5)18-14-30)31-15-19-33(47-6)20-16-31/h7-9,11-21,23,27-28,34-35,37H,10,24-26H2,1-6H3,(H,41,44,45)/t34-,35+,37+,52?/m0/s1

Synonyms: 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine-3'-O-[O-(2-cyanoethyl)-N,N'-diisopropylphosphoramidite]; 2'-Deoxy-5'-O-DMT-uridine 3'-CE Phosphoramidite; DMT-dU Phosphoramidite; 5-O-(4,4'-dimethoxytrityl)-3-O-(diisopropylamino-2-cyanoethoxyphosphanyl)-1,2-dideoxy-1-uracil-1-yl-beta-D-erythro-pentofuranose; 3'-O-[(Diisopropylamino)(2-cyanoethoxy)phosphino]-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine

5'-DMT-2'-O-TBDMS-PseudoUridine-CE-Phosphoramidite

Description: 5'-DMT-2'-O-TBDMS-PseudoUridine-CE-Phosphoramidite is a valuable compound primarily employed for the research and development of RNA molecules required for diagnostic purposes or therapeutic interventions. This compound plays a crucial role in the development of drugs targeting specific diseases and disorders, such as cancers or viral infections. It facilitates efficient nucleotide incorporation and ensures accurate development of RNA sequences.

CAT: BRP-00129

CAS: 163496-23-9

Molecular Formula: C45H61N4O9PSi

Molecular Weight: 861.05

Purity: ≥95%

Appearance: White, off-white to light yellow powder

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1 g	$798	In stock

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Storage: Storage at -20°C

InChIKey: JPJHNALDAAZFFN-LMNGBUJGSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)C2=CNC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: (2R,3R,4S,5S)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C45H61N4O9PSi/c1-30(2)49(31(3)4)59(55-27-15-26-46)57-40-38(56-39(37-28-47-43(51)48-42(37)50)41(40)58-60(10,11)44(5,6)7)29-54-45(32-16-13-12-14-17-32,33-18-22-35(52-8)23-19-33)34-20-24-36(53-9)25-21-34/h12-14,16-25,28,30-31,38-41H,15,27,29H2,1-11H3,(H2,47,48,50,51)/t38-,39+,40-,41+,59?/m1/s1

Synonyms: 2'-O-tert-Butyldimethylsilyl-5'-O-DMT-pseudoUridine 3'-CE phosphoramidite; PseudoUridine-CE Phosphoramidite; Pseudouridine CEP; 5-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-O-[(1,1-dimethylethyl)dimethylsilyl]-beta-D-ribofuranosyl]-2,4(1H,3H)-pyrimidinedione; 5'-O-DMTr-2'-O-TBDMS-Pseudouridine-3'-CE Phosphoramidite; 5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyl-dimethylsilyl)-Pseudouridine-3'-cyanoethyl-Phosphoramidite

Phosphoramidochloridic acid, N,N-dimethyl-, [(2S,6R)-6-[6-(benzoylamino)-9H-purin-9-yl]-4-(triphenylmethyl)-2-morpholinyl]methyl ester

Description: Phosphoramidochloridic acid, N,N-dimethyl-, [(2S,6R)-6-[6-(benzoylamino)-9H-purin-9-yl]-4-(triphenylmethyl)-2-morpholinyl]methyl ester is a novel biomedical compound. With its unique molecular structure, it exhibits potential as a targeted therapeutic agent for treating various diseases.

CAT: BRP-00134

CAS: 956139-18-7

Molecular Formula: C38H37ClN7O4P

Molecular Weight: 722.17

Purity: ≥98% by HPLC

Appearance: White to off-white powder

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1 g	$386	In stock

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Storage: Store at -20 °C

Density: 1.34±0.1 g/cm3

InChIKey: HRNHOEBQNIMEGD-RJFDGRJRSA-N

CanonicalSMILES: CN(C)P(=O)(OCC1CN(CC(O1)N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)C(C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7)Cl

IUPAC Name: N-[9-[(2R,6S)-6-[[chloro(dimethylamino)phosphoryl]oxymethyl]-4-tritylmorpholin-2-yl]purin-6-yl]benzamide

InChI: InChI=1S/C38H37ClN7O4P/c1-44(2)51(39,48)49-25-32-23-45(38(29-17-9-4-10-18-29,30-19-11-5-12-20-30)31-21-13-6-14-22-31)24-33(50-32)46-27-42-34-35(40-26-41-36(34)46)43-37(47)28-15-7-3-8-16-28/h3-22,26-27,32-33H,23-25H2,1-2H3,(H,40,41,43,47)/t32-,33+,51?/m0/s1

Synonyms: Morpholino A subunit; PMO-BzA; [(2S,6R)-6-[6-(Benzoylamino)-9H-purin-9-yl]-4-(triphenylmethyl)-2-morpholinyl]methyl N,N-dimethylphosphoramidochloridate; N6-Bz protected A PMO Monomer

[(2S,6R)-6-{N4-Benzoylcydin-1-yl}-4-tritylmorpholin-2-yl]methyl dimethyl-phosphoramidochloridate

Description: This product is a potent inhibitor of Abl kinases and was developed for the treatment of chronic myeloid leukemia (CML). It works by blocking the activity of the Bcr-Abl fusion protein, which drives the growth of CML cells. Clinical trials have shown promising results, with high rates of complete remission and durable responses in patients with CML who were resistant or intolerant to previous treatments.

CAT: BRP-00135

CAS: 956139-21-2

Molecular Formula: C37H37ClN5O5P

Molecular Weight: 698.15

Purity: 97%

Appearance: White to off-white powder

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Storage: Store at -20 °C

Density: 1.30±0.1 g/cm3

InChIKey: RCQVHNTXMQCQLT-AUIRFOQBSA-N

CanonicalSMILES: CN(C)P(=O)(OCC1CN(CC(O1)N2C=CC(=NC2=O)NC(=O)C3=CC=CC=C3)C(C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=CC=C6)Cl

IUPAC Name: N-[1-[(2R,6S)-6-[[chloro(dimethylamino)phosphoryl]oxymethyl]-4-tritylmorpholin-2-yl]-2-oxopyrimidin-4-yl]benzamide

InChI: InChI=1S/C37H37ClN5O5P/c1-41(2)49(38,46)47-27-32-25-42(26-34(48-32)43-24-23-33(40-36(43)45)39-35(44)28-15-7-3-8-16-28)37(29-17-9-4-10-18-29,30-19-11-5-12-20-30)31-21-13-6-14-22-31/h3-24,32,34H,25-27H2,1-2H3,(H,39,40,44,45)/t32-,34+,49?/m0/s1

Synonyms: PMO-BzC; Morpholino C subunit; Phosphoramidochloridic acid, N,N-dimethyl-, [(2S,6R)-6-[4-(benzoylamino)-2-oxo-1(2H)-pyrimidinyl]-4-(triphenylmethyl)-2-morpholinyl]methyl ester; [(2S,6R)-6-[4-(Benzoylamino)-2-oxo-1(2H)-pyrimidinyl]-4-(triphenylmethyl)-2-morpholinyl]methyl N,N-dimethylphosphoramidochloridate; N4-Bz protected C PMO Monomer

2'-tBDSilyl Adenosine (n-PAC) CED phosphoramidite

Description: 2'-tBDSilyl Adenosine (n-PAC) CED Phosphoramidite is a specialized reagent used in oligonucleotide synthesis. It incorporates a 2'-tert-butyldimethylsilyl (tBDSilyl) group onto the adenosine (A) nucleoside at the 2'-position. Additionally, it features a nitrilotriacetic acid (n-PAC) group for chelating metal ions and a controlled-efficiency (CED) phosphoramidite for efficient incorporation during solid-phase synthesis. This reagent enables the production of modified RNA oligonucleotides with improved stability and functionality, suitable for various molecular biology and biotechnology applications, including RNA interference and gene expression studies.

CAT: BRP-00233

CAS: 121058-86-4

Molecular Formula: C54H68N7O9PSi

Molecular Weight: 1018.22

Purity: 95%

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1 g	$598	In stock

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InChIKey: DBCNFFIOULAURJ-NMRDYAFNSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=NC3=C(N=CN=C32)NC(=O)COC4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]purin-6-yl]-2-phenoxyacetamide

InChI: InChI=1S/C54H68N7O9PSi/c1-37(2)61(38(3)4)71(67-32-18-31-55)69-48-45(33-66-54(39-19-14-12-15-20-39,40-23-27-42(63-8)28-24-40)41-25-29-43(64-9)30-26-41)68-52(49(48)70-72(10,11)53(5,6)7)60-36-58-47-50(56-35-57-51(47)60)59-46(62)34-65-44-21-16-13-17-22-44/h12-17,19-30,35-38,45,48-49,52H,18,32-34H2,1-11H3,(H,56,57,59,62)/t45-,48-,49-,52-,71?/m1/s1

Synonyms: PAC-rA CEP; N-blocked-5'-O-DMT-2'-O-TBDMS CED adenosine phosphoramidite; (2R,3R,4R,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(6-(2-phenoxyacetamido)-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; 5'-Dimethoxytrityl-N-phenoxyacetyl-Adenosine, 2'-O-TBDMS-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-N-(phenoxyacetyl)-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; Pac-A-CE phosphoramidite; rA (Pac) CE-Phosphoramidite; 2'-TBDMS Adenosine (n-PAC) CED phosphoramidite

2-O-DMT-sulfonyldiethanol phosphoramidite

Description: 2-O-DMT-sulfonyldiethanol phosphoramidite substantiates its inevitable prowess in the synthesis and alteration of nucleic acids across diverse applications. Unparalleled in its chemical composition, this exceptional concoction facilitates meticulous and efficient manipulation of nucleic acids, thus fostering elevated biomedical exploration with incomparable precision.

CAT: BRP-00249

CAS: 108783-02-4

Molecular Formula: C34H45N2O7PS

Molecular Weight: 656.77

Purity: >95% by HPLC

Appearance: Light-yellow Oil

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10 g	$1299	In stock

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Storage: store at -20 °C

Boiling Point: 717.4±60.0 °C at 760 mmHg

InChIKey: RJDYWMSSNMDIOO-UHFFFAOYSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OCCS(=O)(=O)CCOC(C1=CC=CC=C1)(C2=CC=C(C=C2)OC)C3=CC=C(C=C3)OC

IUPAC Name: 3-[2-[2-[bis(4-methoxyphenyl)-phenylmethoxy]ethylsulfonyl]ethoxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C34H45N2O7PS/c1-27(2)36(28(3)4)44(42-22-10-21-35)43-24-26-45(37,38)25-23-41-34(29-11-8-7-9-12-29,30-13-17-32(39-5)18-14-30)31-15-19-33(40-6)20-16-31/h7-9,11-20,27-28H,10,22-26H2,1-6H3

Synonyms: 2-((2-(bis(4-methoxyphenyl)(phenyl)methoxy)ethyl)sulfonyl)ethyl (2-cyanoethyl) diisopropylphosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-[[2-[bis(4-methoxyphenyl)phenylmethoxy]ethyl]sulfonyl]ethyl 2-cyanoethyl ester; 2-[2-(4,4'-dimethoxytrityloxy)ethylsulfonyl]ethyl-(2-cyanoethyl)-(N,N-diisopropyl)-phosphoramidite; 2-O-DMT-S phosphoramidite; 5'-Phosphate-Amidite; O-DMT-2,2'-sulfonyldiethanol phosphoramidite; 5'-Phosphate-ON Reagent

Bis(2-cyanoethyl)-N,N-diisopropylphosphoramidite

Description: A useful phosphorylating reagent.

CAT: BRP-00308

CAS: 102690-88-0

Molecular Formula: C12H22N3O2P

Molecular Weight: 271.30

Purity: 96%

Appearance: Yellow Liquid

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5 g	$199	In stock
25 g	$733	In stock

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Storage: Store at -20°C under inert atmosphere

Density: 1.039 g/mL at 25°C

Boiling Point: 335.3±27.0°C (Predicted)

InChIKey: LDHWBEHZLFDXCU-UHFFFAOYSA-N

Solubility: Soluble in Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OCCC#N

IUPAC Name: 3-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C12H22N3O2P/c1-11(2)15(12(3)4)18(16-9-5-7-13)17-10-6-8-14/h11-12H,5-6,9-10H2,1-4H3

Synonyms: N,N-bis(1-Methylethyl)phosphoramidous acid bis(2-cyanoethyl) ester; Bis(2-cyanoethyl) diisopropylphosphoramidite; Bis(2-cyanoethoxy)(diisopropylamino)phosphine; Bis(2-cyanoethoxy)-N,N-diisopropylaminophosphine; Phosphoramidous acid, bis(1-methylethyl)-, bis(2-cyanoethyl) ester; Phosphoramidous acid, N,N-bis(1-methylethyl)-, bis(2-cyanoethyl) ester; Bis-cyanoethyl-N,N-diisopropyl CED phosphoramidite

5'-POM-(E)-vinyl phosphonate-2'-O-Me-U-3'-CE-Phosphoramidite

Description: 5'-POM-(E)-vinyl phosphonate-2'-O-Me-U-3'-CE-Phosphoramidite is a sophisticated biochemical utilized in the pharmaceutical industry. This molecule plays a vital role in the synthesis of antiviral medications targeted at treating diseases like Hepatitis C.

CAT: BRP-00319

CAS: 2172373-55-4

Molecular Formula: C32H52N4O13P2

Molecular Weight: 762.72

Purity: ≥98%

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10 mg	$298	In stock

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Storage: Store at -20 °C

InChIKey: AJJPYIXDIHURAB-FQIYNDLNSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=CC(=O)NC2=O)C1OC)C=CP(=O)(OCOC(=O)C(C)(C)C)OCOC(=O)C(C)(C)C)N(C(C)C)C(C)C

IUPAC Name: ((((E)-2-((2R,3R,4R,5R)-3-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-2-yl)vinyl)phosphoryl)bis(oxy))bis(methylene) bis(2,2-dimethylpropanoate)

InChI: InChI=1S/C32H52N4O13P2/c1-21(2)36(22(3)4)50(45-17-12-15-33)49-25-23(48-27(26(25)42-11)35-16-13-24(37)34-30(35)40)14-18-51(41,46-19-43-28(38)31(5,6)7)47-20-44-29(39)32(8,9)10/h13-14,16,18,21-23,25-27H,12,17,19-20H2,1-11H3,(H,34,37,40)/b18-14+/t23-,25-,26-,27-,50?/m1/s1

Synonyms: 5'-POM-vinyl phosphonate, 2'-OMe-U CEP; 2,4(1H,3H)-Pyrimidinedione, 1-[(5E)-6-[bis[(2,2-dimethyl-1-oxopropoxy)methoxy]phosphinyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-5,6-dideoxy-2-O-methyl-β-D-ribo-hex-5-enofuranosyl]-; 1-[(5E)-6-[Bis[(2,2-dimethyl-1-oxopropoxy)methoxy]phosphinyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-5,6-dideoxy-2-O-methyl-β-D-ribo-hex-5-enofuranosyl]-2,4(1H,3H)-pyrimidinedione; 5'-POM-(E)-vinyl phosphonate-2'-O-Me-rU-3'-CE-Phosphoramidite; (E)-5'-VP-2'-OMe-U-CE-Phosphoramidite; 5'-(E)-VP-2'-OMe-U Phosphoramidite

2'-O-Propargyl A(Bz)-3'-phosphoramidite

Description: 2'-O-Propargyl A(Bz)-3'-phosphoramidite, a highly versatile compound, plays a pivotal role in the biomedical sector for crafting customized oligonucleotides. Its exceptional propargyl and benzoyl functionalities facilitate seamless bonding with a wide range of biomolecules. Hailed for its profound impact in drug discovery, this product aids in the creation of nucleic acid-driven therapeutics, notably those combating diverse ailments such as cancer, viral infections, and neurodegenerative disorders. Its paramount significance in the field underscores the significance of this remarkable compound.

CAT: BRP-00320

CAS: 171486-59-2

Molecular Formula: C50H54N7O8P

Molecular Weight: 911.98

Purity: ≥95%

Appearance: White, off-white to faint yellow powder

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500 mg	$519	In stock

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Storage: Store at -20 °C

InChIKey: ZNKFQCJEZKZIPC-XOMUZYEBSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OCC#C)N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-prop-2-ynoxyoxolan-2-yl]purin-6-yl]benzamide

InChI: InChI=1S/C50H54N7O8P/c1-8-29-61-45-44(65-66(63-30-15-28-51)57(34(2)3)35(4)5)42(64-49(45)56-33-54-43-46(52-32-53-47(43)56)55-48(58)36-16-11-9-12-17-36)31-62-50(37-18-13-10-14-19-37,38-20-24-40(59-6)25-21-38)39-22-26-41(60-7)27-23-39/h1,9-14,16-27,32-35,42,44-45,49H,15,29-31H2,2-7H3,(H,52,53,55,58)/t42-,44-,45-,49-,66?/m1/s1

Synonyms: N4-Bz-5'-O-DMTr-2'-O-propargyladenosine-3'-CED-phosphoramidite; N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-propargyladenosine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite; N6-Benzoyl-5'-O-DMT-2'-O-propynyladenosine 3'-CE phosphoramidite; N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-2-propyn-1-yl-adenosine 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; N-Benzoyl-2'-O-(2-propynyl)-3'-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-5'-O-[phenylbis(4-methoxyphenyl)methyl]adenosine; DMTr-2'-O-propargyl-rA(Bz)-3'-CE-Phosphoramidite; 2'-O-propargyl Adenosine (n-bz) CED phosphoramidite; N6-Bz-DMT-2'-O-propargyl-A-CE-Phosphoramidite; [N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-propargyl-adenosine]-3'-[(2-cyanoethyl)-N,N-diisopropyl]phosphoramidite

5'-O-DMT-2'-O-TBDMS-2-Thiouridine 3'-CE phosphoramidite

Description: 5'-O-DMT-2'-O-TBDMS-2-Thiouridine 3'-CE phosphoramidite is a phosphoramidite derivative used for the solid-phase research and development of modified RNA sequences. With its 5'-O-DMT protection, 2'-O-TBDMS modification and 2-thiouridine incorporation, it enables the controlled research and development of RNA molecules for studying RNA-protein interactions and RNA-based therapeutics targeting diseases like cancer and viral infections.

CAT: BRP-01626

CAS: 163496-21-7

Molecular Formula: C45H61N4O8PSSi

Molecular Weight: 877.11

Purity: >95%

Appearance: Off-white solid

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InChIKey: BLKYMIQDVIRXHA-OHKMQFRXSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=CC(=O)NC2=S)C1O[Si](C)(C)C(C)(C)C)COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)N(C(C)C)C(C)C

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-5-(4-oxo-2-sulfanylidenepyrimidin-1-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C45H61N4O8PSSi/c1-31(2)49(32(3)4)58(54-29-15-27-46)56-40-38(55-42(48-28-26-39(50)47-43(48)59)41(40)57-60(10,11)44(5,6)7)30-53-45(33-16-13-12-14-17-33,34-18-22-36(51-8)23-19-34)35-20-24-37(52-9)25-21-35/h12-14,16-26,28,31-32,38,40-42H,15,29-30H2,1-11H3,(H,47,50,59)/t38-,40-,41-,42-,58?/m1/s1

Synonyms: 2'-OTBS 2-Thio-U amidite; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-2-thio-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-2-thio-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

5'-O-DMT-5-Fluoro-2'-deoxyuridine-3'-CE Phosphoramidite

Description: 5'-O-DMT-5-Fluoro-2'-deoxyuridine-3'-CE Phosphoramidite is a highly potent reagent for the synthesis of 5-fluorouracil (5-FU) containing oligonucleotides, with potential applications in the treatment of cancer. By boosting the selectivity and efficacy of 5-FU, a well-established chemotherapy drug for different forms of cancer, this compound constitutes a promising avenue to enhance the therapeutic options available to patients.

CAT: BRP-01749

CAS: 142246-63-7

Molecular Formula: C39H46FN4O8P

Molecular Weight: 748.78

Purity: ≥98% by HPLC

Appearance: White to Off-white powder

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InChIKey: QXDBDJDCIBKCKF-QMTPQUJBSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1CC(OC1COC(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)C4=CC=C(C=C4)OC)N5C=C(C(=O)NC5=O)F

IUPAC Name: 3-[[(2R,3S,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(5-fluoro-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C39H46FN4O8P/c1-26(2)44(27(3)4)53(50-22-10-21-41)52-34-23-36(43-24-33(40)37(45)42-38(43)46)51-35(34)25-49-39(28-11-8-7-9-12-28,29-13-17-31(47-5)18-14-29)30-15-19-32(48-6)20-16-30/h7-9,11-20,24,26-27,34-36H,10,22-23,25H2,1-6H3,(H,42,45,46)/t34-,35+,36+,53?/m0/s1

Synonyms: 5-F-dU Phosphoramidite; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-5-fluoro-, 3'-[2-cyanoethylbis(1-methylethyl)phosphoramidite]; 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-5-fluoro-uridine 3'-[2-cyanoethylbis(1-methylethyl)phosphoramidite]; FdU-amidite; NSC-729744

N4-Benzoyl-2'-deoxy-5'-O-DMT-2',2'-difluorocytidine 3'-CE phosphoramidite

Description: N4-Benzoyl-2'-deoxy-5'-O-DMT-2',2'-difluorocytidine 3'-CE phosphoramidite is an indispensable compound within the biomedical domain with widespread application as a phosphoramidite constituent during oligonucleotide synthesis, primarily in the research of antisense therapy and gene silencing.

CAT: BRP-01976

CAS: 142808-44-4

Molecular Formula: C46H50F2N5O8P

Molecular Weight: 869.89

Purity: ≥95%

Appearance: White to Off-white Powder

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InChIKey: XLVPZSDAOMSDQP-XBADOKRKSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1(F)F)N2C=CC(=NC2=O)NC(=O)C3=CC=CC=C3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: N-[1-[(2R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3,3-difluorooxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide

InChI: InChI=1S/C46H50F2N5O8P/c1-31(2)53(32(3)4)62(59-29-13-27-49)61-41-39(60-43(46(41,47)48)52-28-26-40(51-44(52)55)50-42(54)33-14-9-7-10-15-33)30-58-45(34-16-11-8-12-17-34,35-18-22-37(56-5)23-19-35)36-20-24-38(57-6)25-21-36/h7-12,14-26,28,31-32,39,41,43H,13,29-30H2,1-6H3,(H,50,51,54,55)/t39-,41-,43-,62?/m1/s1

Synonyms: N4-Bz-DMT-2',2'-difluoro-dC-CE-Phosphoramidite; DMTr-2',2'-difluoro-dC(Bz)-3'-CED-phosphoramidite; Gemcitabine amidite; Gemcitabine 3'-CE phosporamidite; N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2',2'-difluoro-2'-deoxycytidine 3'-O-[(2-cyanoethyl)(N,N-diisopropyl)]phosphoramidite; 5'-O-DMT-N4-Benzoyl-2',2'-difluoro-2'-deoxycytidine 3'-CE phosphoramidite; 5'-DMT-N4-Bz-2',2'-difluoro-dC 3'-CE phosphoramidite

5-Methyl-2'-Fluoro-U Phosphoramidite

Description: 5-Methyl-2'-Fluoro-U Phosphoramidite, a pivotal compound with paramount significance in the domain of biomedicine, assumes the role of a fundamental constituent within the intricate framework of synthesized nucleic acids. Its exceptional utility lies in its indispensable contribution to the progressive advancement of antisense oligonucleotide development. Notably, this phosphoramidite possesses an intrinsic capacity to effectively combat a myriad of ailments encompassing viral infections and genetic disorders, by selectively targeting specified genes or RNA sequences.

CAT: BRP-02020

CAS: 182700-06-7

Molecular Formula: C40H48FN4O8P

Molecular Weight: 762.82

Purity: 95%

Appearance: White to off-white powder

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InChIKey: XUCJAZSCNJHDKP-ANEPUODISA-N

CanonicalSMILES: CC1=CN(C(=O)NC1=O)C2C(C(C(O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OP(N(C(C)C)C(C)C)OCCC#N)F

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-fluoro-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C40H48FN4O8P/c1-26(2)45(27(3)4)54(51-23-11-22-42)53-36-34(52-38(35(36)41)44-24-28(5)37(46)43-39(44)47)25-50-40(29-12-9-8-10-13-29,30-14-18-32(48-6)19-15-30)31-16-20-33(49-7)21-17-31/h8-10,12-21,24,26-27,34-36,38H,11,23,25H2,1-7H3,(H,43,46,47)/t34-,35-,36-,38-,54?/m1/s1

Synonyms: 5-Me-5'-O-DMT-2'-fluoro-2'-Deoxyuridine 3'-CE phosphoramidite; 2'-F T amidite; 2'-Fluoro-dT Phosphoramidite; 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxy-2'-fluoro-5-methyluridine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-5-methyl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; 2'-Fluoro-5MeU-3'-phosphoramidite; DMTr-2'-F-dT-3'-CE-Phosphoramidite; DMT-5-Me-2'-F-dU-CE-Phosphoramidite

N-Benzoyl-5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite (BRP-02153)

Description: N-Benzoyl-5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite is a classic protected 2-OTBDMS phosphoramidite used to incorporate nucleoside A into the synthesis of oligonucleotides.

CAT: BRP-02153

CAS: 104992-55-4

Molecular Formula: C53H66N7O8PSi

Molecular Weight: 988.22

Purity: ≥98% by HPLC

Appearance: White to Off-white Powder

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InChIKey: FFXHNCNNHASXCT-RFMFGJHUSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC

InChI: InChI=1S/C53H66N7O8PSi/c1-36(2)60(37(3)4)69(65-32-18-31-54)67-46-44(33-64-53(39-21-16-13-17-22-39,40-23-27-42(62-8)28-24-40)41-25-29-43(63-9)30-26-41)66-51(47(46)68-70(10,11)52(5,6)7)59-35-57-45-48(55-34-56-49(45)59)58-50(61)38-19-14-12-15-20-38/h12-17,19-30,34-37,44,46-47,51H,18,32-33H2,1-11H3,(H,55,56,58,61)/t44-,46-,47-,51-,69?/m1/s1

Synonyms: Bz-rA Phosphoramidite; DMT-2'O-TBDMS-rA(Bz) Phosphoramidite; 5'-O-DMT-2'-O-tert-Butyldimethylsiyl-N6-Benzoyl-adenosine 3'-CE phosphoramidite; N6-Benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-adenosine 3'-CE phosphoramidite; 5'-O-DMT-2'-O-TBDMS-rA(Bz) 3'-CE phosphoramidite; DMT-2'-O-TBDMS-A(Bz)-CE-Phosphoramidite; N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyl-dimethylsilyl)-adenosine-3'-cyanoethyl Phosphoramidite

5'-O-DMT-2'-O-methyluridine 3'-CE phosphoramidite (BRP-02154)

Description: 5'-O-DMT-2'-O-methyluridine 3'-CE phosphoramidite is a phosphoramidite reagent used to introduce 2-O-methyl modified U nucleotide into oligonucleotides.

CAT: BRP-02154

CAS: 110764-79-9

Molecular Formula: C40H49N4O9P

Molecular Weight: 760.81

Purity: ≥95%

Appearance: White to Off-white Powder

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InChIKey: UVUOJOLPNDCIHL-XKZJCBTISA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OC)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(2,4-dioxopyrimidin-1-yl)-4-methoxyoxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C40H49N4O9P/c1-27(2)44(28(3)4)54(51-25-11-23-41)53-36-34(52-38(37(36)49-7)43-24-22-35(45)42-39(43)46)26-50-40(29-12-9-8-10-13-29,30-14-18-32(47-5)19-15-30)31-16-20-33(48-6)21-17-31/h8-10,12-22,24,27-28,34,36-38H,11,25-26H2,1-7H3,(H,42,45,46)/t34-,36-,37-,38-,54?/m1/s1

Synonyms: 5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyluridine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite; 2'-Deoxy-2'-O-Me-5'-O-DMT-Uridine-3'-CED Phosphoramidite; 2'-OMe-U-CEP; 5'-Dimethoxytrityl-Uridine, 2'-O-methyl, 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; 2'-O-Methyl-3'-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5'-O-(4,4'-dimethoxytrityl)uridine

5'-DMT-2'-O-TBDMS-rU Phosphoramidite (BRP-02155)

Description: 5'-DMT-2'O-TBDMS-rU Phosphoramidite is a classic 2-OTBDMS phosphoramidite used to incorporate U into synthetic oligonucleotides.

CAT: BRP-02155

CAS: 118362-03-1

Molecular Formula: C45H61N4O9PSi

Molecular Weight: 861.04

Purity: ≥97%

Appearance: White to Off-white Powder

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Storage: Store at -20 °C, under nitrogen

InChIKey: SKNLXHRBXYGJOC-ZMHKPELYSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-5-(2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C45H61N4O9PSi/c1-31(2)49(32(3)4)59(55-29-15-27-46)57-40-38(56-42(48-28-26-39(50)47-43(48)51)41(40)58-60(10,11)44(5,6)7)30-54-45(33-16-13-12-14-17-33,34-18-22-36(52-8)23-19-34)35-20-24-37(53-9)25-21-35/h12-14,16-26,28,31-32,38,40-42H,15,29-30H2,1-11H3,(H,47,50,51)/t38-,40-,41-,42-,59?/m1/s1

Synonyms: rU Phosphoramidite; (2R,3R,4R,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; DMT-2'-O-TBDMS-rU Phosphoramidite; 5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]uridine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite; 2'-O-tert-Butyldimethylsilyl-5'-O-DMT-uridine 3'-CE phosphoramidite; 5'-DMT-2'-O-TBDMS-Uridine Phosphoramidite; DMT-2'-O-TBDMS-U-CE-Phosphoramidite; 5'-O-(4,4'-Dimethoxytrityl)-2'-O-(t-butyl-dimethylsilyl)-uridine-3'-cyanoethyl Phosphoramidite

Ac-rC Phosphoramidite (BRP-02156)

Description: Ac-rC Phosphoramidite is a commonly used protected 2-OTBDMS phosphoramidite for incorporating cytidine nucleotides into synthetic oligonucleotides.

CAT: BRP-02156

CAS: 121058-88-6

Molecular Formula: C47H64N5O9PSi

Molecular Weight: 902.11

Purity: ≥98% by HPLC

Appearance: White to Off-white Powder

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Storage: Store at 2-8 °C

InChIKey: QKWKXYVKGFKODW-YOEDQOPESA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=CC(=NC2=O)NC(=O)C)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]-2-oxopyrimidin-4-yl]acetamide

InChI: InChI=1S/C47H64N5O9PSi/c1-32(2)52(33(3)4)62(58-30-16-28-48)60-42-40(59-44(43(42)61-63(11,12)46(6,7)8)51-29-27-41(49-34(5)53)50-45(51)54)31-57-47(35-17-14-13-15-18-35,36-19-23-38(55-9)24-20-36)37-21-25-39(56-10)26-22-37/h13-15,17-27,29,32-33,40,42-44H,16,30-31H2,1-12H3,(H,49,50,53,54)/t40-,42-,43-,44-,62?/m1/s1

Synonyms: N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]cytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite; 5'-O-DMT-2'-O-tert-butyldimethylsilyl-N4-Acetyl-cytidine 3'-CE phosphoramiditee; 5'-O-(4,4'-DiMethoxytrityl)-N4-acetyl-2'-O-t-butyldimethylsilylcytidine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite; 5'-O-DMTr-N4-Ac-2'-O-TBDMS-cytidine-3'-CED PhosphoraMidite; DMT-2'-O-TBDMS-rC(ac) Phosphoramidite; 2'-TBDMS-Ac-rC-CE-Phosphoramidite; 5'-DMT-2'-O-TBDMS-N4-Acetyl-Cytidine Phosphoramidite

Related CAS: 237060-94-5 (S-isomer)

5'-O-(4,4'-Dimethoxytrityl)-2'-deoxy-2'-fluorouridine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite (BRP-02157)

Description: 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxy-2'-fluorouridine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite is a modified phosphoramidite designed for use in the synthesis of stable and efficient RNA and DNA oligonucleotides. Its protective groups and modifications enhance the stability of the resulting nucleic acids and facilitate their incorporation into nucleic acid chains during solid-phase synthesis. This compound is crucial in the production of antisense oligonucleotides, siRNA, probes, and primers, providing enhanced resistance to enzymatic degradation and improved performance in various applications.

CAT: BRP-02157

CAS: 146954-75-8

Molecular Formula: C39H46FN4O8P

Molecular Weight: 748.78

Purity: ≥98%

Appearance: White to Off-white Powder

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InChIKey: HQHQPAYRJJMYQX-DJTPZYMWSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1F)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(2,4-dioxopyrimidin-1-yl)-4-fluorooxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C39H46FN4O8P/c1-26(2)44(27(3)4)53(50-24-10-22-41)52-36-33(51-37(35(36)40)43-23-21-34(45)42-38(43)46)25-49-39(28-11-8-7-9-12-28,29-13-17-31(47-5)18-14-29)30-15-19-32(48-6)20-16-30/h7-9,11-21,23,26-27,33,35-37H,10,24-25H2,1-6H3,(H,42,45,46)/t33-,35-,36-,37-,53?/m1/s1

Synonyms: 2'-F-dU Phosphoramidite; DMT-2'Fluoro-dU Phosphoramidite; 5'-O-Dimethoxytrityl-2'-fluoro-2'-deoxyuridine 3'-CE phosphoramidite; 2'-Deoxy-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-fluorouridine 3-CE phosphoramidite; DMT-2'-Fluoro-dU amidite; 2'-Fluoro-2'-deoxy Uridine CED Phosphoramidite; 2'-Deoxy-5'-O-DMT-2'-fluorouridine 3-CE phosphoramidite; 5'-O-DMT-2'-F-dU 3'-CE phosphoramidite

5'-O-DMT-2'-O-tert-Butyldimethylsilyl-N2-isobutyrylguanosine 3'-CE phosphoramidite (BRP-02158)

Description: 5'-O-DMT-2'-O-tert-Butyldimethylsilyl-N2-isobutyrylguanosine 3'-CE phosphoramidite is a classic protected 2-OTBDMS phosphoramidite used for incorporating ribo-G into synthetic oligonucleotides.

CAT: BRP-02158

CAS: 147201-04-5

Molecular Formula: C50H68N7O9PSi

Molecular Weight: 970.18

Purity: ≥98% by HPLC

Appearance: White to yellow solid

Size	Price	Stock	Quantity
25 g	$399	In stock

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Storage: Store at -20 °C

InChIKey: PGJKESPHANLWME-FTZVBZPOSA-N

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N(C(C)C)C(C)C)OCCC#N)O[Si](C)(C)C(C)(C)C

InChI: InChI=1S/C50H68N7O9PSi/c1-32(2)45(58)54-48-53-44-41(46(59)55-48)52-31-56(44)47-43(66-68(12,13)49(7,8)9)42(65-67(63-29-17-28-51)57(33(3)4)34(5)6)40(64-47)30-62-50(35-18-15-14-16-19-35,36-20-24-38(60-10)25-21-36)37-22-26-39(61-11)27-23-37/h14-16,18-27,31-34,40,42-43,47H,17,29-30H2,1-13H3,(H2,53,54,55,58,59)/t40-,42-,43-,47-,67?/m1/s1

Synonyms: 5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]-N-isobutyrylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite; iBu-rG CE phosphoramidite; DMT-2'-O-TBDMS-rG(iBu) Phosphoramidite; 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-2'-O-[dimethyl(2-methyl-2-propanyl)silyl]-N-isobutyrylguanosine; 5'-O-DMT-2'-O-TBDMS-N2-Isobutyryl-Guanosine-CE Phosphoramidite; 2'-TBDMS-ibu-G-CE-Phosphoramidite; DMT-2'-O-TBDMS-G(iBu)-CE-Phosphoramidite; N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyl-dimethylsilyl)-guanosine-3'-cyanoethyl Phosphoramidite

2'-OMe-dmf-G-CE Phosphoramidite

5'-O-DMT-2'-deoxyuridine-3'-CE Phosphoramidite

5'-DMT-2'-O-TBDMS-PseudoUridine-CE-Phosphoramidite

Phosphoramidochlorid​ic acid, N,​N-​dimethyl-​, [(2S,​6R)​-​6-​[6-​(benzoylamino)​-​9H-​purin-​9-​yl]​-​4-​(triphenylmethyl)​-​2-​morpholinyl]​methyl ester

[(2S,6R)-6-{N4-Benzoylcydin-1-yl}-4-tritylmorpholin-2-yl]methyl dimethyl-phosphoramidochloridate

2'-tBDSilyl Adenosine (n-PAC) CED phosphoramidite

2-O-DMT-sulfonyldiethanol phosphoramidite

Bis(2-cyanoethyl)-N,N-diisopropylphosphoramidite

5'-POM-(E)-vinyl phosphonate-2'-O-Me-U-3'-CE-Phosphoramidite

2'-O-Propargyl A(Bz)-3'-phosphoramidite

5'-O-DMT-2'-O-TBDMS-2-Thiouridine 3'-CE phosphoramidite

5'-O-DMT-5-Fluoro-2'-deoxyuridine-3'-CE Phosphoramidite

N4-Benzoyl-2'-deoxy-5'-O-DMT-2',2'-difluorocytidine 3'-CE phosphoramidite

5-Methyl-2'-Fluoro-U Phosphoramidite

N-Benzoyl-5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite (BRP-02153)

5'-O-DMT-2'-O-methyluridine 3'-CE phosphoramidite (BRP-02154)

5'-DMT-2'-O-TBDMS-rU Phosphoramidite (BRP-02155)

Ac-rC Phosphoramidite (BRP-02156)

5'-O-(4,4'-Dimethoxytrityl)-2'-deoxy-2'-fluorouridine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite (BRP-02157)

5'-O-DMT-2'-O-tert-Butyldimethylsilyl-N2-isobutyrylguanosine 3'-CE phosphoramidite (BRP-02158)

Phosphoramidochloridic acid, N,N-dimethyl-, [(2S,6R)-6-[6-(benzoylamino)-9H-purin-9-yl]-4-(triphenylmethyl)-2-morpholinyl]methyl ester