Phosphoramidites

5'-DMT-2'-OMe-5-Me-U-3'-PS-Phosphoramidite

Description: 5'-DMT-2'-OMe-5-Me-U-3'-PS-Phosphoramidite is a specialized nucleotide used in oligonucleotide synthesis. It consists of a dimethoxytrityl (DMT) protecting group at the 5' position, a 2'-O-methyl modification on the ribose sugar, and a 5-methyluridine base. Additionally, it features a phosphorothioate (PS) linkage at the 3' position. This phosphoramidite facilitates controlled addition during synthesis and enhances stability, making it suitable for various applications in molecular biology research, including gene synthesis, RNA interference, and nucleic acid probe development.

CAT: BRP-00411

Molecular Formula: C45H50N3O9PS2

Molecular Weight: 872.00

Purity: ≥90% by HPLC

Appearance: White to yellow powder

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InChIKey: IWVGGTNZQUQJEA-MWUWPPOZSA-N

CanonicalSMILES: CC1=CN(C(=O)NC1=O)C2C(C(C(O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OP(N6CCCC6)SCCSC(=O)C7=CC=CC=C7)OC

IUPAC Name: S-[2-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-methoxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-pyrrolidin-1-ylphosphanyl]sulfanylethyl] benzenecarbothioate

InChI: InChI=1S/C45H50N3O9PS2/c1-31-29-48(44(51)46-41(31)49)42-40(54-4)39(57-58(47-25-11-12-26-47)60-28-27-59-43(50)32-13-7-5-8-14-32)38(56-42)30-55-45(33-15-9-6-10-16-33,34-17-21-36(52-2)22-18-34)35-19-23-37(53-3)24-20-35/h5-10,13-24,29,38-40,42H,11-12,25-28,30H2,1-4H3,(H,46,49,51)/t38-,39-,40-,42-,58?/m1/s1

Synonyms: [5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-5-methyl-uridine]-3'-[S-(β-(Benzoylmercapto)ethyl)Pyrrolidino Thiophosphoroamidite]; S-(2-(((((2R,3R,4R,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)oxy)(pyrrolidin-1-yl)phosphino)thio)ethyl) benzothioate

5'-DMT-2'-O-MOE-5-Me-U-3'-PS-Phosphoramidite

Description: 5'-DMT-2'-O-MOE-5-Me-U-3'-PS-Phosphoramidite is a specialized nucleotide used in oligonucleotide synthesis. It comprises a dimethoxytrityl (DMT) protecting group at the 5' position, a 2'-O-methoxyethyl (MOE) modification on the ribose sugar, and a 5-methyluridine base. Additionally, it contains a phosphorothioate (PS) linkage at the 3' position. This phosphoramidite facilitates controlled addition during synthesis and enhances stability, making it suitable for various applications in molecular biology research, including gene synthesis, RNA interference, and nucleic acid probe development.

CAT: BRP-00412

CAS: 2360826-70-4

Molecular Formula: C47H54N3O10PS2

Molecular Weight: 916.05

Purity: ≥90% by HPLC

Appearance: White to yellow powder

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InChIKey: VCDBYBSSVSRJPT-OMRXSTERSA-N

CanonicalSMILES: O=C(SCCSP(OC1C(OC(N2C=C(C(=O)NC2=O)C)C1OCCOC)COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)N6CCCC6)C=7C=CC=CC7

IUPAC Name: S-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)oxy)(pyrrolidin-1-yl)phosphaneyl)thio)ethyl) benzothioate

InChI: InChI=1S/C47H54N3O10PS2/c1-33-31-50(46(53)48-43(33)51)44-42(57-28-27-54-2)41(60-61(49-25-11-12-26-49)63-30-29-62-45(52)34-13-7-5-8-14-34)40(59-44)32-58-47(35-15-9-6-10-16-35,36-17-21-38(55-3)22-18-36)37-19-23-39(56-4)24-20-37/h5-10,13-24,31,40-42,44H,11-12,25-30,32H2,1-4H3,(H,48,51,53)/t40-,41-,42-,44-,61?/m1/s1

Synonyms: [5'-O-(4,4'-dimethoxytrityl)-2'-O-methoxyethyl-5-methyl-uridine]-3'-[S-(β-(Benzoylmercapto)ethyl)Pyrrolidino Thiophosphoroamidite]

5'-DMT-2'-O-MOE-U-3'-PS-Phosphoramidite

Description: 5'-DMT-2'-O-MOE-U-3'-PS-Phosphoramidite is a specialized nucleotide used in oligonucleotide synthesis. It consists of a dimethoxytrityl (DMT) protecting group at the 5' position, a 2'-O-methoxyethyl (MOE) modification on the ribose sugar, and a uridine base. Additionally, it contains a phosphorothioate (PS) linkage at the 3' position. This phosphoramidite facilitates controlled addition during synthesis and enhances stability, making it suitable for various applications in molecular biology research, including gene synthesis, RNA interference, and nucleic acid probe development.

CAT: BRP-00413

CAS: 2360826-71-5

Molecular Formula: C46H52N3O10PS2

Molecular Weight: 902.03

Purity: ≥90% by HPLC

Appearance: White to yellow powder

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InChIKey: SDTFEZZYTOLLHY-SRYSXPHVSA-N

CanonicalSMILES: O=C(SCCSP(OC1C(OC(N2C=CC(=O)NC2=O)C1OCCOC)COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)N6CCCC6)C=7C=CC=CC7

IUPAC Name: S-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl)oxy)(pyrrolidin-1-yl)phosphaneyl)thio)ethyl) benzothioate

InChI: InChI=1S/C46H52N3O10PS2/c1-53-28-29-56-42-41(59-60(48-25-10-11-26-48)62-31-30-61-44(51)33-12-6-4-7-13-33)39(58-43(42)49-27-24-40(50)47-45(49)52)32-57-46(34-14-8-5-9-15-34,35-16-20-37(54-2)21-17-35)36-18-22-38(55-3)23-19-36/h4-9,12-24,27,39,41-43H,10-11,25-26,28-32H2,1-3H3,(H,47,50,52)/t39-,41-,42-,43-,60?/m1/s1

Synonyms: [5'-O-(4,4'-dimethoxytrityl)-2'-O-methoxyethyluridine]-3'-[S-(β-(Benzoylmercapto)ethyl)Pyrrolidino Thiophosphoroamidite]

DMT-2'-OMe-N1-Me-Pseudouridine 3'-CE phosphoramidite

Description: DMT-2'-OMe-N1-Me-Pseudouridine 3'-CE phosphoramidite is a compound utilized in nucleic acid synthesis, particularly in RNA synthesis. It comprises various functional groups including DMT (4,4'-Dimethoxytrityl) for protection, 2'-OMe for 2'-O-methylation, N1-Me for N1-methylation, and 3'-CE for 3'-cyanoethyl protection, along with a phosphoramidite moiety for incorporation into nucleotide chains.

CAT: BRP-00426

Molecular Formula: C41H51N4O9P

Molecular Weight: 744.85

Purity: ≥98% by HPLC

Appearance: White to off-white powder

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InChIKey: GVNBVKSXXSEBDA-QKBNJDQWSA-N

IUPAC Name: (2R,3R,4S,5S)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxy-5-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C41H51N4O9P/c1-27(2)45(28(3)4)55(52-24-12-23-42)54-37-35(53-36(38(37)50-8)34-25-44(5)40(47)43-39(34)46)26-51-41(29-13-10-9-11-14-29,30-15-19-32(48-6)20-16-30)31-17-21-33(49-7)22-18-31/h9-11,13-22,25,27-28,35-38H,12,24,26H2,1-8H3,(H,43,46,47)/t35-,36+,37-,38+,55?/m1/s1

Synonyms: 5'-DMT-2'-O-Me-N1-Me-PseudoUridine-CE-Phosphoramidite; N1-Methyl-2'-O-Methyl-5'-O-DMT-pseudoUridine 3'-CE phosphoramidite; DMT-2'-OMe-N1-Me-Pseudouridine

3'-DMT-2'-OMe-A(Bz)-CE Reverse

Description: 3'-DMT-2'-OMe-A(Bz)-CE Reverse is a specialized nucleotide compound used in oligonucleotide synthesis. It comprises a 2'-O-methyl modification and a 3'-DMT protecting group to ensure stability during synthesis. Additionally, the adenosine base is modified with a benzoyl (Bz) group. The 5'-CED phosphoramidite functionality allows for controlled addition to oligonucleotide chains, offering precision in molecular biology research for customized oligonucleotide design and synthesis.

CAT: BRP-00427

CAS: 1309448-27-8

Molecular Formula: C48H54N7O8P

Molecular Weight: 887.96

Purity: ≥98% by HPLC

Appearance: White to off-white powder

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InChIKey: ZTDLWOHDFXTWBU-PSVHYZMASA-N

CanonicalSMILES: N#CCCOP(OCC1OC(N2C=NC=3C(=NC=NC32)NC(=O)C=4C=CC=CC4)C(OC)C1OC(C=5C=CC=CC5)(C6=CC=C(OC)C=C6)C7=CC=C(OC)C=C7)N(C(C)C)C(C)C

IUPAC Name: ((2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-3-(bis(4-methoxyphenyl)(phenyl)methoxy)-4-methoxytetrahydrofuran-2-yl)methyl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C48H54N7O8P/c1-32(2)55(33(3)4)64(60-28-14-27-49)61-29-40-42(43(59-7)47(62-40)54-31-52-41-44(50-30-51-45(41)54)53-46(56)34-15-10-8-11-16-34)63-48(35-17-12-9-13-18-35,36-19-23-38(57-5)24-20-36)37-21-25-39(58-6)26-22-37/h8-13,15-26,30-33,40,42-43,47H,14,28-29H2,1-7H3,(H,50,51,53,56)/t40-,42-,43-,47-,64?/m1/s1

Synonyms: Adenosine, N-benzoyl-3'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 5'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; 3'-O-DMTr-2'-O-Me-A(Bz)-5'-CE-Phosphoramidite; 2'-O-Methyl-3'-DMT Adenosine (n-bz) 5'-CED phosphoramidite

3'-DMT-2'-OMe-G(iBu)-CE Reverse

Description: 3'-DMT-2'-OMe-G(iBu)-CE Reverse is a specialized nucleotide compound used in oligonucleotide synthesis. It consists of a 2'-O-methyl modification and a 3'-DMT protecting group to ensure stability during synthesis. Additionally, the guanosine base is modified with an isobutyryl (ibu) group. The 5'-CED phosphoramidite functionality allows for controlled addition to oligonucleotide chains, providing precision in molecular biology research for tailored oligonucleotide design and synthesis.

CAT: BRP-00428

CAS: 2721427-31-0

Molecular Formula: C45H56N7O9P

Molecular Weight: 869.96

Purity: ≥98% by HPLC

Appearance: White to off-white powder

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InChIKey: ZRRIKKNCSIFYAP-MLLDKZSOSA-N

CanonicalSMILES: N#CCCOP(OCC1OC(N2C=NC=3C(=O)N=C(NC(=O)C(C)C)NC32)C(OC)C1OC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C

IUPAC Name: ((2R,3R,4R,5R)-3-(bis(4-methoxyphenyl)(phenyl)methoxy)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-methoxytetrahydrofuran-2-yl)methyl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C45H56N7O9P/c1-28(2)41(53)49-44-48-40-37(42(54)50-44)47-27-51(40)43-39(57-9)38(36(60-43)26-59-62(58-25-13-24-46)52(29(3)4)30(5)6)61-45(31-14-11-10-12-15-31,32-16-20-34(55-7)21-17-32)33-18-22-35(56-8)23-19-33/h10-12,14-23,27-30,36,38-39,43H,13,25-26H2,1-9H3,(H2,48,49,50,53,54)/t36-,38-,39-,43-,62?/m1/s1

Synonyms: 3'-O-DMTr-2'-O-Me-G(iBu)-5'-CE-Phosphoramidite; 2'-O-Methyl-3'-DMT Guanosine (n-ibu) 5'-CED phosphoramidite

3'-DMT-2'-OMe-C(Ac)-CE Reverse

Description: 3'-DMT-2'-OMe-C(Ac)-CE Reverse is a specialized nucleotide compound used in oligonucleotide synthesis. It features a 2'-O-methyl modification and a 3'-DMT protecting group to ensure stability during synthesis. Additionally, the cytidine base is modified with an acetyl (N-Ac) group. The 5'-CED phosphoramidite functionality enables controlled addition to oligonucleotide chains, providing precision in molecular biology research for customized oligonucleotide design and synthesis.

CAT: BRP-00429

Molecular Formula: C42H52N5O9P

Molecular Weight: 801.88

Purity: ≥98% by HPLC

Appearance: White to off-white powder

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InChIKey: ZAQGXRDUFSXSGR-UAQIPLLRSA-N

IUPAC Name: ((2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-3-(bis(4-methoxyphenyl)(phenyl)methoxy)-4-methoxytetrahydrofuran-2-yl)methyl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C42H52N5O9P/c1-28(2)47(29(3)4)57(53-26-12-24-43)54-27-36-38(39(52-8)40(55-36)46-25-23-37(44-30(5)48)45-41(46)49)56-42(31-13-10-9-11-14-31,32-15-19-34(50-6)20-16-32)33-17-21-35(51-7)22-18-33/h9-11,13-23,25,28-29,36,38-40H,12,26-27H2,1-8H3,(H,44,45,48,49)/t36-,38-,39-,40-,57?/m1/s1

Synonyms: 3'-O-DMTr-2'-O-Me-C(Ac)-5'-CE-Phosphoramidite; 2'-O-Methyl-3'-DMT Cytidine (N-Ac) 5'-CED phosphoramidite

3'-O-DMTr-2'-O-Me-rU-5'-CE-Phosphoramidite

Description: 3'-O-DMTr-2'-O-Me-rU-5'-CE-Phosphoramidite is a specialized nucleotide used in oligonucleotide synthesis. It contains a 3'-dimethoxytrityl (DMTr) protecting group on the 3' hydroxyl, a methyl (Me) modification at the 2' position of the ribose sugar with uracil (U) as the base, and a 5'-cyanoethyl (CE) phosphoramidite functionality for controlled addition during synthesis. This compound facilitates stable and precise synthesis of customized oligonucleotides for molecular biology research applications.

CAT: BRP-00430

CAS: 2721427-32-1

Molecular Formula: C40H49N4O9P

Molecular Weight: 760.82

Purity: ≥98% by HPLC

Appearance: White to off-white powder

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InChIKey: ATKRAEVWEXDALJ-XKZJCBTISA-N

CanonicalSMILES: N#CCCOP(OCC1OC(N2C=CC(=O)NC2=O)C(OC)C1OC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)N(C(C)C)C(C)C

IUPAC Name: ((2R,3R,4R,5R)-3-(bis(4-methoxyphenyl)(phenyl)methoxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-2-yl)methyl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C40H49N4O9P/c1-27(2)44(28(3)4)54(50-25-11-23-41)51-26-34-36(37(49-7)38(52-34)43-24-22-35(45)42-39(43)46)53-40(29-12-9-8-10-13-29,30-14-18-32(47-5)19-15-30)31-16-20-33(48-6)21-17-31/h8-10,12-22,24,27-28,34,36-38H,11,25-26H2,1-7H3,(H,42,45,46)/t34-,36-,37-,38-,54?/m1/s1

Synonyms: 3'-DMT-2'-OMe-U-CE Reverse; 2'-O-Methyl-3'-DMT Uridine 5'-CED phosphoramidite

UNA-C(Ac)-CE Phosphoramidite

Description: UNA-C(Ac)-CE Phosphoramidite is a compound employed in the chemical synthesis of nucleic acids, specifically in RNA synthesis. It features a UNA (Unlocked Nucleic Acid) modification, denoted by "UNA," which alters the structure and properties of the nucleotide. The "C(Ac)" indicates the nucleotide base cytosine (C) with an acetyl (Ac) group attached, potentially impacting base pairing and stability. Additionally, "CE" denotes cyanoethyl, a protecting group for the phosphate moiety, and "Phosphoramidite" refers to the reactive form of the nucleotide used in automated oligonucleotide synthesis. This compound facilitates controlled addition of modified nucleotides during RNA synthesis for various research and biotechnological applications.

CAT: BRP-00431

CAS: 1120329-56-7

Molecular Formula: C48H56N5O10P

Molecular Weight: 893.96

Purity: ≥98% by HPLC

Appearance: White to off-white powder

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InChIKey: UMUWXRLDMCRCFS-GXOVKUNTSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OCC(COC(C1=CC=CC=C1)(C2=CC=C(C=C2)OC)C3=CC=C(C=C3)OC)OC(COC(=O)C4=CC=CC=C4)N5C=CC(=NC5=O)NC(=O)C

IUPAC Name: [(2R)-2-(4-acetamido-2-oxopyrimidin-1-yl)-2-[(2R)-1-[bis(4-methoxyphenyl)-phenylmethoxy]-3-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxypropan-2-yl]oxyethyl] benzoate

InChI: InChI=1S/C48H56N5O10P/c1-34(2)53(35(3)4)64(61-30-14-28-49)62-32-43(63-45(33-59-46(55)37-15-10-8-11-16-37)52-29-27-44(50-36(5)54)51-47(52)56)31-60-48(38-17-12-9-13-18-38,39-19-23-41(57-6)24-20-39)40-21-25-42(58-7)26-22-40/h8-13,15-27,29,34-35,43,45H,14,30-33H2,1-7H3,(H,50,51,54,56)/t43-,45-,64?/m1/s1

Synonyms: (2R)-2-(4-Acetamido-2-oxopyrimidin-1(2H)-yl)-2-(((2R)-1-(bis(4-methoxyphenyl)(phenyl)methoxy)-3-(((2-cyanoethoxy)(diisopropylamino)phosphino)oxy)propan-2-yl)oxy)ethyl benzoate; Phosphoramidous acid, N,N-bis(1-methylethyl)-, (2R)-2-[(1R)-1-[4-(acetylamino)-2-oxo-1(2H)-pyrimidinyl]-2-(benzoyloxy)ethoxy]-3-[bis(4-methoxyphenyl)phenylmethoxy]propyl 2-cyanoethyl ester; (2R)-2-[(1R)-1-[4-(Acetylamino)-2-oxo-1(2H)-pyrimidinyl]-2-(benzoyloxy)ethoxy]-3-[bis(4-methoxyphenyl)phenylmethoxy]propyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite

UNA-U-CE Phosphoramidite

Description: UNA-U-CE Phosphoramidite is a compound utilized in nucleic acid synthesis, particularly in RNA synthesis. It consists of UNA (Unlocked Nucleic Acid), denoted by "UNA," which modifies the nucleotide structure and properties. The "U" signifies uridine as the base, and "CE" indicates cyanoethyl, a protecting group for the phosphate moiety. "Phosphoramidite" refers to the reactive form of the nucleotide used in automated oligonucleotide synthesis. This compound enables controlled addition of modified uridine nucleotides during RNA synthesis for various research and biotechnological applications.

CAT: BRP-00432

CAS: 1120329-48-7

Molecular Formula: C46H53N4O10P

Molecular Weight: 852.91

Purity: ≥98% by HPLC

Appearance: White to off-white powder

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InChIKey: MHRGEJFLFYZLJI-LZOZAVILSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OCC(COC(C1=CC=CC=C1)(C2=CC=C(C=C2)OC)C3=CC=C(C=C3)OC)OC(COC(=O)C4=CC=CC=C4)N5C=CC(=O)NC5=O

IUPAC Name: [(2R)-2-[(2R)-1-[bis(4-methoxyphenyl)-phenylmethoxy]-3-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxypropan-2-yl]oxy-2-(2,4-dioxopyrimidin-1-yl)ethyl] benzoate

InChI: InChI=1S/C46H53N4O10P/c1-33(2)50(34(3)4)61(58-29-13-27-47)59-31-41(60-43(49-28-26-42(51)48-45(49)53)32-56-44(52)35-14-9-7-10-15-35)30-57-46(36-16-11-8-12-17-36,37-18-22-39(54-5)23-19-37)38-20-24-40(55-6)25-21-38/h7-12,14-26,28,33-34,41,43H,13,29-32H2,1-6H3,(H,48,51,53)/t41-,43-,61?/m1/s1

Synonyms: 5'-(4,4'-dimethoxytrityl)-2'-benzoyl-2',3'-seco-uridine-3'-cyanoethyl Phosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, (2R)-2-[(1R)-2-(benzoyloxy)-1-(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)ethoxy]-3-[bis(4-methoxyphenyl)phenylmethoxy]propyl 2-cyanoethyl ester; 5'-DMTr-2'-Bz-3'-O-CEP-UNA-U; 5'-(4,4'-dimethoxytrityl)-2'-benzoyl-2',3'-seco-uridine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)] Phosphoramidite; (2R)-2-[(1R)-2-(Benzoyloxy)-1-(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)ethoxy]-3-[bis(4-methoxyphenyl)phenylmethoxy]propyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite

Morpholino G(PhAc) subunit

Description: The Morpholino G(PhAc) subunit is a component used in the synthesis of morpholino oligomers, synthetic analogs of nucleic acids. It features a morpholine ring structure as the backbone, with a guanine base modified by a phenylacetyl group (PhAc). This modification enhances the binding affinity of the oligomers to complementary RNA or DNA targets. The Morpholino G(PhAc) subunit is utilized in molecular biology and biotechnology for applications such as gene knockdown experiments, antisense therapy, and the study of gene function.

CAT: BRP-00433

CAS: 1044241-74-8

Molecular Formula: C39H39ClN7O5P

Molecular Weight: 752.20

Purity: ≥98% by HPLC

Appearance: White to off-white powder

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Density: 1.37±0.1 g/cm3

InChIKey: NURVOJDGJURYKG-BFXPVMCSSA-N

CanonicalSMILES: O=C1N=C(NC(=O)CC=2C=CC=CC2)NC3=C1N=CN3C4OC(COP(=O)(Cl)N(C)C)CN(C4)C(C=5C=CC=CC5)(C=6C=CC=CC6)C=7C=CC=CC7

IUPAC Name: ((2S,6R)-6-(6-oxo-2-(2-phenylacetamido)-1,6-dihydro-9H-purin-9-yl)-4-tritylmorpholin-2-yl)methyl dimethylphosphoramidochloridate

InChI: InChI=1S/C39H39ClN7O5P/c1-45(2)53(40,50)51-26-32-24-46(39(29-17-9-4-10-18-29,30-19-11-5-12-20-30)31-21-13-6-14-22-31)25-34(52-32)47-27-41-35-36(47)43-38(44-37(35)49)42-33(48)23-28-15-7-3-8-16-28/h3-22,27,32,34H,23-26H2,1-2H3,(H2,42,43,44,48,49)/t32-,34+,53?/m0/s1

Synonyms: Phosphoramidochloridic acid, N,N-dimethyl-, [(2S,6R)-6-[1,6-dihydro-6-oxo-2-[(2-phenylacetyl)amino]-9H-purin-9-yl]-4-(triphenylmethyl)-2-morpholinyl]methyl ester; [(2S,6R)-6-[1,6-Dihydro-6-oxo-2-[(2-phenylacetyl)amino]-9H-purin-9-yl]-4-(triphenylmethyl)-2-morpholinyl]methyl N,N-dimethylphosphoramidochloridate; (2S,6R)-6-(6-oxo-2-(2-phenylacetamido)-1H-purin-9(6H)-yl)-4-tritylmorpholin-2-yl)methyl dimethylphosphoramidochloridate

VIC phosphoramidite, 6-isomer

Description: VIC is an asymmetrical xanthene dye used for the design of qPCR probes. VIC phosphoramidite, 6-isomer allows to introduce the label onto 5'-terminus of the oligonucleotide.

CAT: BRP-00472

CAS: 1414265-81-8

Molecular Formula: C52H59Cl3N3O10P

Molecular Weight: 1023.37

Purity: ≥95%

Appearance: White to Off-white Solid

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Storage: Store at -20 °C

InChIKey: WNXGKJMDPRPEFO-UHFFFAOYSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCCCCCNC(=O)C1=CC(=C2C(=C1Cl)C3(C4=CC(=C(C=C4OC5=C3C=C(C(=C5)OC(=O)C(C)(C)C)C6=CC=CC=C6)OC(=O)C(C)(C)C)Cl)OC2=O)Cl)OCCC#N

IUPAC Name: [4,7,7'-trichloro-6-[6-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyhexylcarbamoyl]-6'-(2,2-dimethylpropanoyloxy)-3-oxo-2'-phenylspiro[2-benzofuran-1,9'-xanthene]-3'-yl] 2,2-dimethylpropanoate

InChI: InChI=1S/C52H59Cl3N3O10P/c1-30(2)58(31(3)4)69(64-24-18-21-56)63-23-17-12-11-16-22-57-46(59)34-26-38(54)43-44(45(34)55)52(68-47(43)60)35-25-33(32-19-14-13-15-20-32)39(66-48(61)50(5,6)7)28-40(35)65-41-29-42(37(53)27-36(41)52)67-49(62)51(8,9)10/h13-15,19-20,25-31H,11-12,16-18,22-24H2,1-10H3,(H,57,59)

Synonyms: 6-VIC Phosphoramidite

XIMA Phosphoramidite II

Description: XIMA Phosphoramidite II is a chemical compound used in oligonucleotide synthesis, particularly in the field of molecular biology and biotechnology. It is a type of phosphoramidite reagent that enables the efficient and precise incorporation of nucleotides during the synthesis of DNA and RNA oligonucleotides. XIMA Phosphoramidite II is valued for its high coupling efficiency and stability, making it a reliable choice for the synthesis of oligonucleotides for various applications, including gene synthesis, PCR primers, and nucleic acid aptamers.

CAT: BRP-00473

Molecular Formula: C84H89Cl2N4O14P

Molecular Weight: 1480.52

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InChIKey: RTFBWGDBWIXUCV-PHEZNKQISA-N

IUPAC Name: 6-((6-((2S,4R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)pyrrolidin-1-yl)-6-oxohexyl)carbamoyl)-4,7-dichloro-3-oxo-2',7'-diphenyl-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-diyl bis(2,2-dimethylpropanoate)

InChI: InChI=1S/C84H89Cl2N4O14P/c1-52(2)90(53(3)4)105(99-43-25-41-87)104-62-44-59(51-98-83(56-30-21-15-22-31-56,57-33-37-60(96-11)38-34-57)58-35-39-61(97-12)40-36-58)89(50-62)73(91)32-23-16-24-42-88-77(92)65-47-68(85)74-75(76(65)86)84(103-78(74)93)66-45-63(54-26-17-13-18-27-54)69(101-79(94)81(5,6)7)48-71(66)100-72-49-70(102-80(95)82(8,9)10)64(46-67(72)84)55-28-19-14-20-29-55/h13-15,17-22,26-31,33-40,45-49,52-53,59,62H,16,23-25,32,42-44,50-51H2,1-12H3,(H,88,92)/t59-,62+,105?/m0/s1

Synonyms: SIMA phosphoramidite, 6-isomer hydroxyprolinol

XIMA Phosphoramidite II

CAT: BRP-00473

Molecular Formula: C84H89Cl2N4O14P

Molecular Weight: 1480.52

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InChIKey: RTFBWGDBWIXUCV-PHEZNKQISA-N

Synonyms: SIMA phosphoramidite, 6-isomer hydroxyprolinol

5'-Aquafluor 593 CE Phosphoramidite

Description: Aquafluor 593 is a highly fluorescent molecule with maximum absorption at 593 nm and maximum emission at 613 nm, with a quantum yield of 0.6. The fluorescence of Aquafluor 593 is very little affected by pH, with only a few percent variation in the pH range of 5-8. Moreover, when heated from 20°C to 95°C, the fluorescence only decreased by about 30%.

CAT: BRP-00476

CAS: 2378004-16-9

Molecular Formula: C57H78F3N6O8P2+

Molecular Weight: 1094.23

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InChIKey: MMNHPDDWLXVTRC-UHFFFAOYSA-O

CanonicalSMILES: N#CCCOP(OCCCCCCOP(=O)(OCCCCNC(=O)C(F)(F)F)C=1C=CC(C(=O)N(CC)CC)=C(C1)C=2C=3C=C4C5=C(C3[O+]=C6C2C=C7C8=C6CCCN8CCC7)CCCN5CCC4)N(C(C)C)C(C)C

InChI: InChI=1S/C57H77F3N6O8P2/c1-7-63(8-2)55(67)44-25-24-43(76(69,73-35-14-11-27-62-56(68)57(58,59)60)72-34-13-10-9-12-32-70-75(71-33-19-26-61)66(39(3)4)40(5)6)38-47(44)50-48-36-41-20-15-28-64-30-17-22-45(51(41)64)53(48)74-54-46-23-18-31-65-29-16-21-42(52(46)65)37-49(50)54/h24-25,36-40H,7-23,27-35H2,1-6H3/p+1

Synonyms: 5'-AquaPhluor 593; 1H,5H,11H,15H-Xantheno[2,3,4-ij:5,6,7-i'j']diquinolizin-18-ium, 9-[5-[10-[bis(1-methylethyl)amino]-13-cyano-1-oxido-1-[4-[(2,2,2-trifluoroacetyl)amino]butoxy]-2,9,11-trioxa-1,10-diphosphatridec-1-yl]-2-[(diethylamino)carbonyl]phenyl]-2,3,6,7,12,13,16,17-octahydro-; 9-[5-[10-[Bis(1-methylethyl)amino]-13-cyano-1-oxido-1-[4-[(2,2,2-trifluoroacetyl)amino]butoxy]-2,9,11-trioxa-1,10-diphosphatridec-1-yl]-2-[(diethylamino)carbonyl]phenyl]-2,3,6,7,12,13,16,17-octahydro-1H,5H,11H,15H-xantheno[2,3,4-ij:5,6,7-i'j']diquinolizin-18-ium

Related CAS: 2378004-17-0 (hexafluorophosphate)

Quassar 670 Phosphoramidite

Description: Quasar 670 Phosphoramidite is a specialized chemical used in oligonucleotide synthesis for molecular biology and biotechnology applications. It is a type of phosphoramidite reagent designed to incorporate the Quasar 670 fluorescent dye into synthetic oligonucleotides. This dye is part of the Quasar series of fluorescent dyes, known for their high brightness and photostability. Quasar 670 Phosphoramidite enables the synthesis of labeled oligonucleotides for various applications such as fluorescence in situ hybridization (FISH), real-time PCR, and nucleic acid detection assays. Its incorporation allows researchers to visualize and track nucleic acids in biological samples with high sensitivity and specificity.

CAT: BRP-00478

Molecular Formula: C48H69F6N5O3P2

Molecular Weight: 940.05

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InChIKey: LSSOBLPIXZOCPG-UHFFFAOYSA-O

IUPAC Name: 2-(5-(1-(6-((4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)cyclohexyl)amino)-6-oxohexyl)-3,3-dimethylindolin-2-ylidene)penta-1,3-dien-1-yl)-1-ethyl-3,3-dimethyl-3H-indol-1-ium;hexafluorophosphate

InChI: InChI=1S/C48H68N5O3P.F6P/c1-10-51-42-24-18-16-22-40(42)47(6,7)44(51)26-13-11-14-27-45-48(8,9)41-23-17-19-25-43(41)52(45)34-20-12-15-28-46(54)50-38-29-31-39(32-30-38)56-57(55-35-21-33-49)53(36(2)3)37(4)5;1-7(2,3,4,5)6/h11,13-14,16-19,22-27,36-39H,10,12,15,20-21,28-32,34-35H2,1-9H3;/q;-1/p+1

DusQ 1 phosphoramidite

Description: DusQ 1 phosphoramidite is a true dark quencher with broad absorption curve which covers the visible spectrum with maximum in green to yellow region. It is used for the synthesis of dual labeled oligonucleotide probes for qPCR bearing 5'-quencher DusQ 1 and other FRET applications for multiplexing assays.

CAT: BRP-00479

CAS: 374591-94-3

Molecular Formula: C55H63N8O8P

Molecular Weight: 995.11

Purity: ≥95%

Appearance: Black Powder

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InChIKey: GQGUDTGZCZTGBR-UHFFFAOYSA-N

Solubility: Soluble in acetonitrile

CanonicalSMILES: N#CCCOP(OCCN(C1=CC=C(N=NC2=CC(=C(N=NC3=CC=C(C=C3N(=O)=O)C)C=C2OC)C)C=C1)CCOC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C

IUPAC Name: 2-((2-(bis(4-methoxyphenyl)(phenyl)methoxy)ethyl)(4-((2-methoxy-5-methyl-4-((4-methyl-2-nitrophenyl)diazenyl)phenyl)diazenyl)phenyl)amino)ethyl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C55H63N8O8P/c1-39(2)62(40(3)4)72(70-33-13-30-56)71-35-32-61(31-34-69-55(43-14-11-10-12-15-43,44-17-25-48(66-7)26-18-44)45-19-27-49(67-8)28-20-45)47-23-21-46(22-24-47)57-60-52-37-42(6)51(38-54(52)68-9)59-58-50-29-16-41(5)36-53(50)63(64)65/h10-12,14-29,36-40H,13,31-35H2,1-9H3

Synonyms: Phosphoramidous acid, bis(1-methylethyl)-, 2-[[2-[bis(4-methoxyphenyl)phenylmethoxy]ethyl][4-[[2-methoxy-5-methyl-4-[(4-methyl-2-nitrophenyl)azo]phenyl]azo]phenyl]amino]ethyl 2-cyanoethyl ester (9CI)

DusQ 2 phosphoramidite

Description: DusQ 2 is a dark quenched dye used in the synthesis of double-labeled oligonucleotide probes for qPCR with a 5' quench agent. This quencher is ideal for HEX, JOE, ROX, Cyanine5 and other dyes that have emission spectra in the orange and red parts of the spectrum.

CAT: BRP-00480

CAS: 374591-98-7

Molecular Formula: C54H61N8O9P

Molecular Weight: 997.09

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InChIKey: GISIZSAJGDUWFU-UHFFFAOYSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OCCN(CCOC(C1=CC=CC=C1)(C2=CC=C(C=C2)OC)C3=CC=C(C=C3)OC)C4=CC=C(C=C4)N=NC5=CC(=C(C=C5OC)N=NC6=CC=C(C=C6)[N+](=O)[O-])OC

IUPAC Name: 3-[2-[N-[2-[bis(4-methoxyphenyl)-phenylmethoxy]ethyl]-4-[[2,5-dimethoxy-4-[(4-nitrophenyl)diazenyl]phenyl]diazenyl]anilino]ethoxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C54H61N8O9P/c1-39(2)61(40(3)4)72(70-34-12-31-55)71-36-33-60(32-35-69-54(41-13-10-9-11-14-41,42-15-27-48(65-5)28-16-42)43-17-29-49(66-6)30-18-43)46-23-19-44(20-24-46)56-58-50-37-53(68-8)51(38-52(50)67-7)59-57-45-21-25-47(26-22-45)62(63)64/h9-11,13-30,37-40H,12,32-36H2,1-8H3

Synonyms: HCQ-2 Phosphoramidite; DusQ2 phosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, 2-[[2-[bis(4-methoxyphenyl)phenylmethoxy]ethyl][4-[[2,5-dimethoxy-4-[(4-nitrophenyl)azo]phenyl]azo]phenyl]amino]ethyl 2-cyanoethyl ester; BHQ-2 Phosphoramidite; 4'-(4-Nitro-phenyldiazo)-2'-methoxy-5'-methoxy-azobenzene-4''-(N-2-4,4'-dimethoxytrityl(oxyethyl))-N-ethyl-2-cyanoethyl-(N,N-diisopropyl)-phosphoramidite

5'-Amino-Modifier C3 PDA

Description: 5'-Amino-Modifier C3 PDA is a biomedical research reagent used for oligonucleotide and DNA modification. Its versatility is manifested in facilitating the linking of a variety of molecules, such as antibodies and fluorescent dyes, enabling diagnostic and therapeutic interventions.

CAT: BRP-00481

Molecular Formula: C21H33N4O4P

Molecular Weight: 436.49

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InChIKey: OZSWCSLCEAQVDE-UHFFFAOYSA-N

CanonicalSMILES: CC(N(C(C)C)P(OCCCNC(C1=C(C(NC)=O)C=CC=C1)=O)OCCC#N)C

IUPAC Name: 2-cyanoethyl (3-(2-(methylcarbamoyl)benzamido)propyl) diisopropylphosphoramidite

InChI: InChI=1S/C21H33N4O4P/c1-16(2)25(17(3)4)30(28-14-8-12-22)29-15-9-13-24-21(27)19-11-7-6-10-18(19)20(26)23-5/h6-7,10-11,16-17H,8-9,13-15H2,1-5H3,(H,23,26)(H,24,27)

5'-Amino-Modifier C6 PDA

Description: 5'-Amino-Modifier C6 PDA is a chemical reagent used in oligonucleotide synthesis for molecular biology and biotechnology applications. It is a modification reagent designed to introduce an amino group at the 5' end of synthetic oligonucleotides. This amino group enables further conjugation with various molecules, such as fluorescent dyes, biotin, or other chemical groups, allowing for labeling or functionalization of the oligonucleotides. The C6 designation refers to the presence of a carbon chain spacer (hexyl linker) between the amino group and the phosphate group of the oligonucleotide backbone. This modification is particularly useful for applications such as PCR, sequencing, hybridization assays, and probe-based detection methods.

CAT: BRP-00482

CAS: 1445745-26-5

Molecular Formula: C24H39N4O4P

Molecular Weight: 478.57

Appearance: Light-yellow oily matter

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Storage: Store at -20 °C

InChIKey: MXRKQHDWLCHOMH-UHFFFAOYSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCCCCCNC(=O)C1=CC=CC=C1C(=O)NC)OCCC#N

IUPAC Name: 2-N-[6-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyhexyl]-1-N-methylbenzene-1,2-dicarboxamide

InChI: InChI=1S/C24H39N4O4P/c1-19(2)28(20(3)4)33(32-18-12-15-25)31-17-11-7-6-10-16-27-24(30)22-14-9-8-13-21(22)23(29)26-5/h8-9,13-14,19-20H,6-7,10-12,16-18H2,1-5H3,(H,26,29)(H,27,30)

Synonyms: 6-(N2-methyl-N'-phthalimidyl)-hexyl-1-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; 2-cyanoethyl (6-(2-(methylcarbamoyl)benzamido)hexyl) diisopropylphosphoramidite; PDA-Amino-C6 Amidite; 5'-Amino-Modifier C6-PDA

5'-DMT-2'-OMe-5-Me-U-3'-PS-Phosphoramidite

5'-DMT-2'-O-MOE-5-Me-U-3'-PS-Phosphoramidite

5'-DMT-2'-O-MOE-U-3'-PS-Phosphoramidite

DMT-2'-OMe-N1-Me-Pseudouridine 3'-CE phosphoramidite

3'-DMT-2'-OMe-A(Bz)-CE Reverse

3'-DMT-2'-OMe-G(iBu)-CE Reverse

3'-DMT-2'-OMe-C(Ac)-CE Reverse

3'-O-DMTr-2'-O-Me-rU-5'-CE-Phosphoramidite

UNA-C(Ac)-CE Phosphoramidite

UNA-U-CE Phosphoramidite

Morpholino G(PhAc) subunit

VIC phosphoramidite, 6-isomer

XIMA Phosphoramidite II

XIMA Phosphoramidite II

5'-Aquafluor 593 CE Phosphoramidite

Quassar 670 Phosphoramidite

DusQ 1 phosphoramidite

DusQ 2 phosphoramidite

5'-Amino-Modifier C3 PDA

5'-Amino-Modifier C6 PDA

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