BOC RNA can customize and test CPGs to meet the specific needs of oligonucleotide applications.
What is the controlled pore glass (CPG)?
Controlled pore glass is hard, does not expand, and has deep holes. The CPG carrier does not swell or shrink, and is inert to the reagents used during the synthesis process. Due to the unique rigidity and well-defined pore structure, CPGs are good supports for oligonucleotide synthesis.
CPG types and applications
CPGs have various apertures:
- Glass supports with 500Å (50 nm) pores have mechanical strength and are usually used to synthesis short oligonucleotides. However, the synthesis yield will drop sharply if preparing an oligonucleotide of longer than 40 bases on 500Å resin. This is because the growing oligonucleotides block the pores and reduce the diffusion of reagents through the matrix.
- 1000Å CPG resin can synthesize oligonucleotides up to 100 bases in length.
- The 2000Å carrier can be used for longer oligonucleotide synthesis.
- All products are of no animal origin and no TSE/BSE risk.
- From material procurement to final quality control and product release, the entire process is monitored to provide repeatability and security between batches.
- The tightly controlled manufacturing process ensures minimal levels of impurities.
If you have any questions or requirements, please feel free to contact us.