Phosphoramidites

Description: 1-[(5E)-3-O-[(Bis-diisopropylamino)(2-cyanoethoxy)phosphino]-5,6-dideoxy-6-(diethoxyphosphinyl)-2-O-methyl-β-D-ribohex-5-enofuranosyl]-N2-isobutyroylguanine is a modified phosphoramidite compound used in oligonucleotides synthesis. This compound is primarily used in the solid-phase synthesis of RNA, where the protecting groups ensure that selective reactions occur at the desired sites. The phosphoramidite functionality facilitates the stepwise addition of nucleotides during automated oligonucleotide synthesis, allowing for the controlled assembly of RNA sequences.

CAT: BRP-02475

Molecular Formula: C29H47N7O9P2

Molecular Weight: 699.68

Description: 1-[(5E)-3-O-[(Bis-diisopropylamino)(2-cyanoethoxy)phosphino]-5,6-dideoxy-6-(diethoxyphosphinyl)-2-O-(2-MOE)-β-D-ribo-hex-5-enofuranosyl]uracil is a modified phosphoramidite compound used in oligonucleotides synthesis. This compound is primarily used in the solid-phase synthesis of RNA, where the protecting groups ensure that selective reactions occur at the desired sites. The phosphoramidite functionality facilitates the stepwise addition of nucleotides during automated oligonucleotide synthesis, allowing for the controlled assembly of RNA sequences.

CAT: BRP-02476

Molecular Formula: C26H44N4O10P2

Molecular Weight: 634.60

Description: 5'-O-DMTr-2'-O-Trifluoroacetamindo propyl-C(Ac)-3'-CE-Phosphoramidite is a highly modified cytidine phosphoramidite used in oligonucleotide synthesis. The 5'-O-DMTr (dimethoxytrityl) group serves as a protective group for the 5' hydroxyl during stepwise synthesis. The 2'-O-trifluoroacetamindo propyl modification adds a trifluoroacetamido group linked via a propyl spacer to the 2'-hydroxyl of the ribose, enhancing hydrophobicity and potentially altering enzymatic interactions or duplex stability. The C(Ac) designation indicates that the cytosine base is protected by an acetyl group at the N4 position, ensuring stability during synthesis. The 3'-CE phosphoramidite (cyanoethyl) group enables the coupling of this nucleotide into a growing oligonucleotide chain via phosphoramidite chemistry. This compound is often employed in the synthesis of modified oligonucleotides for research or therapeutic purposes, where specific modifications are required for stability, resistance to degradation, or unique biological functionality.

CAT: BRP-02480

Molecular Formula: C46H56F3N6O10P

Molecular Weight: 940.95

Description: 5'-O-DMTr-5-trifluoroacetylaminomethyl-2'-O-TBDMS uridine 3'-CED phosphoramidite is a chemically modified phosphoramidite designed for oligonucleotide synthesis. Its structure features a 5'-dimethoxytrityl (DMTr) group for temporary protection during solid-phase synthesis, a 5-position trifluoroacetylaminomethyl group to introduce functionalized side chains, a 2'-O-tert-butyldimethylsilyl (TBDMS) group for ribose protection, and a 3'-cyanoethyl diisopropyl phosphoramidite for coupling. This compound is used in the synthesis of RNA oligonucleotides, enabling the incorporation of modified residues for structural, therapeutic, or biochemical applications, such as enhancing stability or introducing specific reactive functionalities.

CAT: BRP-02487

Molecular Formula: C48H63F3N5O10PSi

Molecular Weight: 986.11

Purity: ≥95%

Description: 5'-O-DMTr-2'-O-(N-tri-fluoroacetylamino)ethyl-5-methyluridine 3'-CE-phosphoramidite is a modified phosphoramidite designed for oligonucleotide synthesis. The structure includes a 5-methyluridine base with a 2'-O-(N-tri-fluoroacetylamino)ethyl modification on the ribose, which enhances the molecule's stability and may influence its interaction with biological systems. The 5'-hydroxyl group is protected with a dimethoxytrityl (DMTr) group for efficient coupling during solid-phase synthesis, while the 3'-hydroxyl is protected with a cyanoethyl (CE) phosphoramidite group for coupling in the synthesis process. This modification improves the stability and specificity of the resulting oligonucleotides, making it suitable for use in RNA-based applications, including therapeutic and diagnostic purposes.

CAT: BRP-02490

CAS: 200423-98-9

Molecular Formula: C44H53F3N5O10P

Molecular Weight: 899.89

Purity: ≥95%

Description: It is a modified phosphoramidite designed for medicinal chemistry purposes, likely targeting specific enzymes or pathways in nucleotide metabolism, cell signaling, or as a potential therapeutic agent for diseases where phosphorothioate or phosphonate derivatives play a key role in inhibition or modulation.

CAT: BRP-02493

CAS: 2197181-94-3

Molecular Formula: C21H36N4O10P2

Molecular Weight: 566.48

Purity: ≥95%

Description: 1-O-(4,4'-Dimethoxytrityl)-3-O-succinyl-1,3-propanediol is a bifunctional molecule commonly used as a linker or spacer in the synthesis of oligonucleotides. The 1-hydroxyl group is protected with a 4,4'-dimethoxytrityl (DMT) group, which serves as a temporary protecting group during solid-phase synthesis, enabling stepwise addition of nucleotides. The 3-hydroxyl group is modified with a succinyl moiety, introducing a carboxylic acid functionality that allows covalent attachment to solid supports, such as controlled-pore glass (CPG) or polymers. This compound is critical in oligonucleotide synthesis, ensuring efficient attachment and controlled chain elongation during automated synthesis processes.

CAT: BRP-02496

CAS: 110916-49-9

Molecular Formula: C28H30O7

Molecular Weight: 478.53

Purity: ≥97%

Appearance: White or off-white solid