Phosphoramidites - RNA / BOC Sciences

6-TAMRA phosphoramidite (BRP-02239)

Description: Oligonucleotides modified with TAMRA derivatives can be used for genomic research, molecular diagnosis, and molecular biology.

CAT: BRP-02239

MF: C66H77N6O10P

MF: 1145.35

Purity: >95%

Appearance: Dark red solid

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Storage: Store at -20 °C

Symbol: 5'-TAMRA phosphoramidite (6-TAMRA)

InChIKey: VDRDQKBQFCBCQK-FYICZBFESA-N

Solubility: Soluble in acetonitrile, DCM

IUPAC Name: (3R,5S)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-1-(6-(3',6'-bis(dimethylamino)-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-6-carboxamido)hexanoyl)pyrrolidin-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C66H77N6O10P/c1-44(2)72(45(3)4)83(79-37-17-35-67)82-55-39-52(43-78-65(47-18-13-11-14-19-47,48-22-28-53(76-9)29-23-48)49-24-30-54(77-10)31-25-49)71(42-55)62(73)20-15-12-16-36-68-63(74)46-21-32-56-59(38-46)66(81-64(56)75)57-33-26-50(69(5)6)40-60(57)80-61-41-51(70(7)8)27-34-58(61)66/h11,13-14,18-19,21-34,38,40-41,44-45,52,55H,12,15-17,20,36-37,39,42-43H2,1-10H3,(H,68,74)/t52-,55+,83?/m0/s1

Synonyms: TAMRA phosphoramidite, 6-isomer; N-(6-oxo-6-[(3R,5S)-5-[(4,4'-dimethoxytrityl)-oxymethyl]-3-(N,N-diisopropylamino-2-cyanoethoxyphosphin-oxy)pyrrolidine-1-yl]hexyl)-3',6'-Bis(dimethylamino)-3-oxo-spiro[isobenzofuran-1(3H),9'-[9H]xanthene]-6-yl-carboxamide

6-Fluorescein phosphoramidite (BRP-02240)

Description: 6-Fluorescein phosphoramidite is prepared from 6-carboxyfluorescein derivatives and does not contain 4,4'-dimethoxytrityl (DMT) groups. It can only be added once at the 5'end to terminate the synthesis.

CAT: BRP-02240

CAS: 204697-37-0

MF: C46H58N3O10P

MF: 843.94

Purity: ≥90%

Appearance: White to Off-white Solid

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Storage: Store at -20 °C

Boiling Point: 850.6±65.0°C at 760 mmHg

Symbol: 6-FAM

InChIKey: MGPYJVWEJNTXLC-UHFFFAOYSA-N

Solubility: Soluble in Acetonitrile, DCM

CanonicalSMILES: CC(C)N(C(C)C)P(OCCCCCCNC(=O)C1=CC2=C(C=C1)C(=O)OC23C4=C(C=C(C=C4)OC(=O)C(C)(C)C)OC5=C3C=CC(=C5)OC(=O)C(C)(C)C)OCCC#N

IUPAC Name: [6-[6-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyhexylcarbamoyl]-6'-(2,2-dimethylpropanoyloxy)-3-oxospiro[2-benzofuran-1,9'-xanthene]-3'-yl] 2,2-dimethylpropanoate

InChI: InChI=1S/C46H58N3O10P/c1-29(2)49(30(3)4)60(55-25-15-22-47)54-24-14-12-11-13-23-48-40(50)31-16-19-34-37(26-31)46(59-41(34)51)35-20-17-32(56-42(52)44(5,6)7)27-38(35)58-39-28-33(18-21-36(39)46)57-43(53)45(8,9)10/h16-21,26-30H,11-15,23-25H2,1-10H3,(H,48,50)

Synonyms: FAM Phosphoramidite, 6-Isomer; 6-FAM phosphoramidite; FAM phosphoramidite, 6-isomer; DyLight FAM-6 CEP; 5'(6)-FAM; 5'-6-Fluorescein phosphoramidite; 6-((6-(((2-Cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)hexyl)carbamoyl)-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-diyl bis(2,2-dimethylpropanoate)

5'-VP-2'-OMe-G(iBu)-CE-Phosphoramidite

Description: 5'-VP-2'-OMe-G(iBu)-CE-Phosphoramidite is a reagent used in the solid-phase synthesis of RNA oligonucleotides for incorporating 2'-O-methylguanosine (G) residues. It features a 5'-VP (Vented Protective group) for protection during synthesis, a 2'-O-methyl modification on the guanine ribose to enhance RNA stability, and an isobutyryl (iBu) group protecting the exocyclic amino group of guanine. The reagent also includes a cyanoethyl (CE) phosphoramidite group, which facilitates the coupling of nucleotides during the synthesis process. This configuration is commonly used to create RNA sequences with enhanced resistance to enzymatic degradation, making it ideal for therapeutic and diagnostic applications.

CAT: BRP-02346

MF: C37H59N7O13P2

MF: 871.86

Purity: ≥98%

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InChIKey: BVJBAQGYDLYVPP-UYDHQHTBSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C(=O)N=C(NC(=O)C(C)C)NC32)C1OC)C=CP(=O)(OCOC(=O)C(C)(C)C)OCOC(=O)C(C)(C)C)N(C(C)C)C(C)C

IUPAC Name: (((2-((2R,3R,4R,5R)-3-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-methoxytetrahydrofuran-2-yl)vinyl)phosphoryl)bis(oxy))bis(methylene) bis(2,2-dimethylpropanoate)

InChI: InChI=1S/C37H59N7O13P2/c1-22(2)30(45)41-35-40-29-26(31(46)42-35)39-19-43(29)32-28(50-13)27(57-58(53-17-14-16-38)44(23(3)4)24(5)6)25(56-32)15-18-59(49,54-20-51-33(47)36(7,8)9)55-21-52-34(48)37(10,11)12/h15,18-19,22-25,27-28,32H,14,17,20-21H2,1-13H3,(H2,40,41,42,45,46)/t25-,27-,28-,32-,58?/m1/s1

Synonyms: 5'-POM-vinyl phosphonate-2'-O-Me-rG(iBu)-3'-CE-Phosphoramidite

5'-VP-2'-OMe-C(Ac)-CE-Phosphoramidite

Description: 5'-VP-2'-OMe-C(Ac)-CE-Phosphoramidite is a reagent used in the solid-phase synthesis of RNA oligonucleotides for incorporating 2'-O-methylcytidine (C) residues. It features a 5'-VP (Vented Protective) group for safeguarding the 5' end during synthesis, a 2'-O-methyl modification on the cytidine ribose to enhance the stability and resistance of the RNA to enzymatic degradation, and an acetyl (Ac) group protecting the exocyclic amino group of cytidine. The cyanoethyl (CE) phosphoramidite group facilitates the coupling of nucleotides during the synthesis process. This reagent is particularly useful for creating stable RNA sequences, often used in therapeutic and diagnostic applications.

CAT: BRP-02347

MF: C34H55N5O13P2

MF: 803.78

Purity: ≥98%

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InChIKey: IHTFJGAKRRVDIF-VFAGAGMZSA-N

IUPAC Name: (((2-((2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-3-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-4-methoxytetrahydrofuran-2-yl)vinyl)phosphoryl)bis(oxy))bis(methylene) bis(2,2-dimethylpropanoate)

InChI: InChI=1S/C34H55N5O13P2/c1-22(2)39(23(3)4)53(48-18-13-16-35)52-27-25(51-29(28(27)45-12)38-17-14-26(36-24(5)40)37-32(38)43)15-19-54(44,49-20-46-30(41)33(6,7)8)50-21-47-31(42)34(9,10)11/h14-15,17,19,22-23,25,27-29H,13,18,20-21H2,1-12H3,(H,36,37,40,43)/t25-,27-,28-,29-,53?/m1/s1

Synonyms: 5'-POM-vinyl phosphonate-2'-O-Me-rC(Ac)-3'-CE-Phosphoramidite

FAM-dT Phosphoramidite

Description: FAM-dT phosphoramidite is a conjugate of deoxythymidine phosphoramidite and 6-isomer of FAM.

CAT: BRP-02348

CAS: 637330-26-8

MF: C79H87N6O17P

MF: 1423.54

Appearance: Off White Powder

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InChIKey: FVVPPYBKLBLXEK-FLDIZLHUSA-N

Solubility: Soluble in in acetonitrile, DCM

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1CC(OC1COC(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)C4=CC=C(C=C4)OC)N5C=C(C(=O)NC5=O)C#CCNC(=O)CCCCCNC(=O)C6=CC7=C(C=C6)C(=O)OC78C9=C(C=C(C=C9)OC(=O)C(C)(C)C)OC1=C8C=CC(=C1)OC(=O)C(C)(C)C

IUPAC Name: [6-[[6-[3-[1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]-2,4-dioxopyrimidin-5-yl]prop-2-ynylamino]-6-oxohexyl]carbamoyl]-6'-(2,2-dimethylpropanoyloxy)-3-oxospiro[2-benzofuran-1,9'-xanthene]-3'-yl] 2,2-dimethylpropanoate

InChI: InChI=1S/C79H87N6O17P/c1-49(2)85(50(3)4)103(96-42-20-39-80)102-66-46-69(100-67(66)48-95-78(53-22-15-13-16-23-53,54-26-30-56(93-11)31-27-54)55-28-32-57(94-12)33-29-55)84-47-52(71(88)83-75(84)92)21-19-41-81-68(86)24-17-14-18-40-82-70(87)51-25-36-60-63(43-51)79(101-72(60)89)61-37-34-58(97-73(90)76(5,6)7)44-64(61)99-65-45-59(35-38-62(65)79)98-74(91)77(8,9)10/h13,15-16,22-23,25-38,43-45,47,49-50,66-67,69H,14,17-18,20,24,40-42,46,48H2,1-12H3,(H,81,86)(H,82,87)(H,83,88,92)/t66-,67+,69+,103?/m0/s1

Synonyms: 6-((6-((3-(1-((2R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)tetrahydrofuran-2-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)prop-2-yn-1-yl)amino)-6-oxohexyl)carbamoyl)-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-diyl bis(2,2-dimethylpropanoate); Uridine, 5-[3-[[6-[[[3',6'-bis(2,2-dimethyl-1-oxopropoxy)-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-6-yl]carbonyl]amino]-1-oxohexyl]amino]-1-propynyl]-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

6-Fluorescein dT phosphoramidite

Description: 6-Fluorescein dT phosphoramidite can be inserted into the desired sequence as a replacement for a dT residue during oligonucleotides synthesis.

CAT: BRP-02349

CAS: 1194507-30-6

MF: C79H89N6O17P

MF: 1425.56

Purity: ≥95%

Appearance: Off-white Solid

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Storage: Store at 2-8 °C

InChIKey: CADOGPWQRZBAGJ-FLDIZLHUSA-N

Solubility: Soluble in Anhydrous Acetonitrile

CanonicalSMILES: N#CCCOP(OC1CC(OC1COC(C=2C=CC=CC2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)N5C=C(C=CC(=O)NCCCCCCNC(=O)C6=CC=C7C(=O)OC8(C9=CC=C(OC(=O)C(C)(C)C)C=C9OC%10=CC(OC(=O)C(C)(C)C)=CC=C%108)C7=C6)C(=O)NC5=O)N(C(C)C)C(C)C

IUPAC Name: 6-((6-(3-(1-((2R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)tetrahydrofuran-2-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)acrylamido)hexyl)carbamoyl)-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-diyl bis(2,2-dimethylpropanoate)

InChI: InChI=1S/C79H89N6O17P/c1-49(2)85(50(3)4)103(96-42-20-39-80)102-66-46-69(100-67(66)48-95-78(53-21-16-15-17-22-53,54-25-29-56(93-11)30-26-54)55-27-31-57(94-12)32-28-55)84-47-52(71(88)83-75(84)92)24-38-68(86)81-40-18-13-14-19-41-82-70(87)51-23-35-60-63(43-51)79(101-72(60)89)61-36-33-58(97-73(90)76(5,6)7)44-64(61)99-65-45-59(34-37-62(65)79)98-74(91)77(8,9)10/h15-17,21-38,43-45,47,49-50,66-67,69H,13-14,18-20,40-42,46,48H2,1-12H3,(H,81,86)(H,82,87)(H,83,88,92)/t66-,67+,69+,103?/m0/s1

Synonyms: Uridine, 5-[3-[[6-[[[3',6'-bis(2,2-dimethyl-1-oxopropoxy)-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-6-yl]carbonyl]amino]hexyl]amino]-3-oxo-1-propen-1-yl]-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; 5'-Dimethoxytrityloxy-5-[N-((3',6'-dipivaloylfluoresceinyl)-aminohexyl)-3-acrylimido]-2'-deoxyuridine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; Fluorescein-dT Phosphoramidite; Fluorescein dT CEP; 6-FAM-dT Phosphoramidite

HEX-dT Phosphoramidite

Description: HEX-dT phosphoramidite contains a DMT group to allow quantification of coupling. It can be inserted into a target sequence as a replacement for a dT residue. It provides a valuable tool to add the HEX tag to a desired location of an oligo sequence. It is complimentary to the commonly used 6-HEX phosphoramidite that contains no DMT group and can only be added at the 5'-terminus, thus terminating synthesis.

CAT: BRP-02350

MF: C79H83Cl6N6O17P

MF: 1632.23

Appearance: Solid

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Storage: Store at -20 °C

InChIKey: PYHVUSJUSKKCHB-YNKBEQGLSA-N

IUPAC Name: 6-((6-(3-(1-((2R,4S,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)tetrahydrofuran-2-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)acrylamido)hexyl)carbamoyl)-2',4,4',5',7,7'-hexachloro-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-diyl bis(2,2-dimethylpropanoate)

InChI: InChI=1S/C79H83Cl6N6O17P/c1-43(2)91(44(3)4)109(102-36-20-33-86)108-57-40-60(103-58(57)42-101-78(46-21-16-15-17-22-46,47-24-28-49(99-11)29-25-47)48-26-30-50(100-12)31-27-48)90-41-45(70(93)89-75(90)98)23-32-59(92)87-34-18-13-14-19-35-88-71(94)51-37-54(80)61-62(63(51)83)79(107-72(61)95)52-38-55(81)68(105-73(96)76(5,6)7)64(84)66(52)104-67-53(79)39-56(82)69(65(67)85)106-74(97)77(8,9)10/h15-17,21-32,37-39,41,43-44,57-58,60H,13-14,18-20,34-36,40,42H2,1-12H3,(H,87,92)(H,88,94)(H,89,93,98)/t57-,58+,60+,109?/m0/s1

SIMA (HEX)-dT Phosphoramidite

Description: SIMA (HEX)-dT Phosphoramidite embodies an exquisite chemical reagent, which, when employed in the synthesis of oligonucleotides, brings forth labeling with fluorescent prowess. This sky-high labeling capacity, what with its hexachlorofluorescein (HEX) dye and the thymidine base, can be ushered into diverse biomedical applications, including the fluoroescence in situ hybridization (FISH), DNA sequencing and detecting specific genetic mutations or diseases.

CAT: BRP-02351

MF: C91H95Cl2N6O17P

MF: 1646.64

Purity: ≥95%

Appearance: White powder

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Storage: Store at -20 °C

InChIKey: KPIIJRDTWQIEJL-WLPPFOLSSA-N

Solubility: Soluble in Anhydrous Acetonitrile, DCM

IUPAC Name: 6-((6-((3-(1-((2R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)tetrahydrofuran-2-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)allyl)amino)-6-oxohexyl)carbamoyl)-4,7-dichloro-3-oxo-2',7'-diphenyl-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-diyl bis(2,2-dimethylpropanoate)

InChI: InChI=1S/C91H95Cl2N6O17P/c1-55(2)99(56(3)4)117(110-46-26-43-94)116-75-52-78(112-76(75)54-109-90(60-32-21-15-22-33-60,61-35-39-63(107-11)40-36-61)62-37-41-64(108-12)42-38-62)98-53-59(82(101)97-87(98)106)31-25-45-95-77(100)34-23-16-24-44-96-83(102)67-49-70(92)79-80(81(67)93)91(115-84(79)103)68-47-65(57-27-17-13-18-28-57)71(113-85(104)88(5,6)7)50-73(68)111-74-51-72(114-86(105)89(8,9)10)66(48-69(74)91)58-29-19-14-20-30-58/h13-15,17-22,25,27-33,35-42,47-51,53,55-56,75-76,78H,16,23-24,26,34,44-46,52,54H2,1-12H3,(H,95,100)(H,96,102)(H,97,101,106)/t75-,76+,78+,117?/m0/s1

Synonyms: SIMA-dT phosphoramidite, 6-isomer; 5'-Dimethoxytrityl-5-[6-((2',7'-diphenyl-4,7-dichloro-3',6'-dipivaloylfluorescein-6-yl-carboxamido)-hexanoyl)-3-aminoallyl]-2'-deoxyUridine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite

2-[5-[1-[6-[[trans-4-[[[Bis(1-methylethyl)amino](2-cyanoethyl)phosphino]oxy]cyclohexyl]amino]-6-oxohexyl]-1,3-dihydro-3,3-dimethyl-2H-indol-2-ylidene]-1,3-pentadien-1-yl]-1,3,3-trimethyl-3H-indolium, hexafluorophosphate(1-) (1:1)

Description: It is a type of fluorescent probe. Its highly conjugated structure, including the indolium-based chromophores, enables it to emit fluorescence upon excitation, making it useful in various applications such as imaging, detection, and analytical studies in biological and chemical environments. The specific functional groups and substituents enhance its solubility, stability, and interaction with target molecules, making it a versatile tool in fluorescence-based assays.

CAT: BRP-02352

CAS: 1032678-33-3

MF: C47H67N5O2P.F6P

MF: 910.01

Purity: ≥95%

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InChIKey: CXTKSIZCEDZHOE-PVMSMBLDNA-O

CanonicalSMILES: N#CCCP(OC1CCC(NC(=O)CCCCCN2C=3C=CC=CC3C(C2=CC=CC=CC4=[N+](C=5C=CC=CC5C4(C)C)C)(C)C)CC1)N(C(C)C)C(C)C.[F-][P+5]([F-])([F-])([F-])([F-])[F-]

IUPAC Name: 1-(6-(((1r,4r)-4-(((2-cyanoethyl)(diisopropylamino)phosphaneyl)oxy)cyclohexyl)amino)-6-oxohexyl)-3,3-dimethyl-2-(5-(1,3,3-trimethylindolin-2-ylidene)penta-1,3-dien-1-yl)-3H-indol-1-ium;hexafluorophosphate

InChI: InChI=1/C47H66N5O2P.F6P/c1-35(2)52(36(3)4)55(34-20-32-48)54-38-30-28-37(29-31-38)49-45(53)27-14-11-19-33-51-42-24-18-16-22-40(42)47(7,8)44(51)26-13-10-12-25-43-46(5,6)39-21-15-17-23-41(39)50(43)9;1-7(2,3,4,5)6/h10,12-13,15-18,21-26,35-38H,11,14,19-20,27-31,33-34H2,1-9H3;/q;-1/p+1/t37-,38-,55?;

Synonyms: 3H-Indolium, 2-[5-[1-[6-[[trans-4-[[[bis(1-methylethyl)amino](2-cyanoethyl)phosphino]oxy]cyclohexyl]amino]-6-oxohexyl]-1,3-dihydro-3,3-dimethyl-2H-indol-2-ylidene]-1,3-pentadien-1-yl]-1,3,3-trimethyl-, hexafluorophosphate(1-) (1:1)

Related CAS: 1032678-32-2 (free base)

Quasar 670 Amidite

Description: Quasar 670 Amidite is a fluorescent dye amidite used in the synthesis of labeled oligonucleotides. It incorporates the Quasar 670 dye, which emits in the far-red region of the spectrum, into the oligonucleotide during solid-phase synthesis. This dye is commonly used for applications in molecular biology and diagnostics, including fluorescence-based assays, real-time PCR, and other nucleic acid detection methods. The far-red fluorescence of Quasar 670 provides advantages in minimizing background interference and allows for multiplexing with other dyes.

CAT: BRP-02353

CAS: 1207163-26-5

MF: C46H67N5O4P.F6P

MF: 929.99

Purity: ≥95%

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InChIKey: YDZHKALIHBAHCU-UHFFFAOYSA-O

CanonicalSMILES: N#CCCOP(OCCOCCNC(=O)CCCCCN1C=2C=CC=CC2C(C1=CC=CC=CC3=[N+](C=4C=CC=CC4C3(C)C)CC)(C)C)N(C(C)C)C(C)C.[F-][P+5]([F-])([F-])([F-])([F-])[F-]

IUPAC Name: 1-(6-((2-(2-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)ethoxy)ethyl)amino)-6-oxohexyl)-2-(5-(1-ethyl-3,3-dimethylindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium;hexafluorophosphate

InChI: InChI=1S/C46H66N5O4P.F6P/c1-10-49-40-24-18-16-22-38(40)45(6,7)42(49)26-13-11-14-27-43-46(8,9)39-23-17-19-25-41(39)50(43)31-20-12-15-28-44(52)48-30-33-53-34-35-55-56(54-32-21-29-47)51(36(2)3)37(4)5;1-7(2,3,4,5)6/h11,13-14,16-19,22-27,36-37H,10,12,15,20-21,28,30-35H2,1-9H3;/q;-1/p+1

Synonyms: 3H-Indolium, 2-[5-[1-[14-[bis(1-methylethyl)amino]-17-cyano-6-oxo-10,13,15-trioxa-7-aza-14-phosphaheptadec-1-yl]-1,3-dihydro-3,3-dimethyl-2H-indol-2-ylidene]-1,3-pentadienyl]-1-ethyl-3,3-dimethyl-, hexafluorophosphate(1-) (1:1); Quasar 670 CE Phosphoramidite; Quasar 670 Phosphoramidite

Related CAS: 865651-00-9 (free base) ; 865611-62-7 (iodide salt)

Quasar 670-dT Phosphoramidite

Description: Quasar 670 dyes are cyanine derivatives of Cyanine 5. Cyanine dyes are a popular oligonucleotide modification and are commonly used for imaging, flow cytometry, and genomic applications.

CAT: BRP-02354

MF: C81H102F6N8O10P2

MF: 1523.69

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Solubility: Soluble in Anhydrous Acetonitrile

IUPAC Name: 2-(5-(1-(6-((6-(3-(1-((2R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)tetrahydrofuran-2-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)acrylamido)hexyl)amino)-6-oxohexyl)-3,3-dimethylindolin-2-ylidene)penta-1,3-dien-1-yl)-1-ethyl-3,3-dimethyl-3H-indol-1-ium;hexafluorophosphate

Synonyms: 5'-Dimethoxytrityloxy-5-[(N-(6-(N1-ethyl-3,3,3',3'-tetramethylindodicarbocyanin-1'-yl)hexanoyl)-aminohexyl)-3-acrylimido]-2'-deoxyUridine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite, hexafluorophosphate salt

BHQ-1-dT CE Phosphoramidite

Description: BHQ-1-dT, a widely utilized reagent in the biomedicine realm, remains pertinent for nucleic acid detection and DNA sequencing. Its potential significance surfaces in disease and genetic disorder determination alongside viral load monitoring in infectious cases. From a development standpoint, BHQ-1-dT fosters therapeutic targeting of nucleic acids.

CAT: BRP-02355

MF: C74H89N12O14P

MF: 1401.56

Purity: ≥95%

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InChIKey: MNVPAZMXRNVVHL-KGKIMOMESA-N

Solubility: Soluble in Anhydrous Acetonitrile/Dichloromethane 1:3 (v/v)

CanonicalSMILES: CCN(CCOC(=O)NCCCCCCNC(=O)C=CC1=CN(C(=O)NC1=O)C2CC(C(O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OP(N(C(C)C)C(C)C)OCCC#N)C6=CC=C(C=C6)N=NC7=C(C=C(C(=C7)C)N=NC8=C(C=C(C=C8)C)[N+](=O)[O-])OC

IUPAC Name: 2-[N-ethyl-4-[[2-methoxy-5-methyl-4-[(4-methyl-2-nitrophenyl)diazenyl]phenyl]diazenyl]anilino]ethyl N-[6-[[3-[1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]-2,4-dioxopyrimidin-5-yl]prop-2-enoyl]amino]hexyl]carbamate

InChI: InChI=1S/C74H89N12O14P/c1-11-83(59-30-28-58(29-31-59)79-82-64-45-53(7)63(46-66(64)95-10)81-80-62-36-22-52(6)44-65(62)86(91)92)41-43-96-73(90)77-40-18-13-12-17-39-76-69(87)37-23-54-48-84(72(89)78-71(54)88)70-47-67(100-101(98-42-19-38-75)85(50(2)3)51(4)5)68(99-70)49-97-74(55-20-15-14-16-21-55,56-24-32-60(93-8)33-25-56)57-26-34-61(94-9)35-27-57/h14-16,20-37,44-46,48,50-51,67-68,70H,11-13,17-19,39-43,47,49H2,1-10H3,(H,76,87)(H,77,90)(H,78,88,89)/b37-23+,81-80?,82-79?/t67-,68+,70+,101?/m0/s1

Synonyms: BHQ-1-dT; HCQ-12-dT Phosphoramidite; 5'-Dimethoxytrityloxy-5-[(N-4''-carboxyethyl-4''-(N-ethyl)-4'-(2-Nitro-4-toluyldiazo)-2'-methoxy-5'-methyl-azobenzene)-aminohexyl-3-acrylimido]-2'-deoxyUridine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; BHQ-1-dT Amidite

BHQ-2-dT

Description: BHQ-2-dT plays a critical role in propelling PCR probes and hybridization assays to new heights of detection, this modified nucleoside serves as a beacon for identifying viral pathogens, genetic diseases, and cancer biomarkers. With its distinctive fluorescent abilities, molecular matching is taken to the next level of precision and accuracy, boosting sensitivity like never before.

CAT: BRP-02356

CAS: 1415097-34-5

MF: C73H87N12O15P

MF: 1403.53

Purity: ≥95%

Appearance: Blue Solid

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InChIKey: QCQIEDGINBSSOG-GOQRVKJUSA-N

Solubility: Soluble in Anhydrous Acetonitrile/Dichloromethane 1:3 (v/v)

CanonicalSMILES: N#CCCOP(OC1CC(OC1COC(C=2C=CC=CC2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)N5C=C(C=CC(=O)NCCCCCCNC(=O)OCCN(C6=CC=C(N=NC7=CC(OC)=C(N=NC8=CC=C(C=C8)N(=O)=O)C=C7OC)C=C6)CC)C(=O)NC5=O)N(C(C)C)C(C)C

IUPAC Name: 2-[4-[[2,5-dimethoxy-4-[(4-nitrophenyl)diazenyl]phenyl]diazenyl]-N-ethylanilino]ethyl N-[6-[[(E)-3-[1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]-2,4-dioxopyrimidin-5-yl]prop-2-enoyl]amino]hexyl]carbamate

InChI: InChI=1S/C73H87N12O15P/c1-10-82(58-30-26-56(27-31-58)78-80-62-45-65(95-9)63(46-64(62)94-8)81-79-57-28-32-59(33-29-57)85(90)91)42-44-96-72(89)76-41-17-12-11-16-40-75-68(86)38-21-52-48-83(71(88)77-70(52)87)69-47-66(100-101(98-43-18-39-74)84(50(2)3)51(4)5)67(99-69)49-97-73(53-19-14-13-15-20-53,54-22-34-60(92-6)35-23-54)55-24-36-61(93-7)37-25-55/h13-15,19-38,45-46,48,50-51,66-67,69H,10-12,16-18,40-44,47,49H2,1-9H3,(H,75,86)(H,76,89)(H,77,87,88)/t66-,67+,69+,101?/m0/s1

Synonyms: HCQ-2-dT Phosphoramidite; BHQ-2-dT CE Phosphoramidite; 5'-Dimethoxytrityloxy-5-[(N-4''-carboxyethyl-4''-(N-ethyl)-4'-(4-Nitro-phenyldiazo)-2'-methoxy-5'-methoxy-azobenzene)-aminohexyl-3-acrylimido]-2'-deoxyUridine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; BHQ-2-dT Phosphoramidite; BHQ-2-dT Amidite

Amino-Modifier C6 dT

Description: Amino-Modifier C6 dT is a pivotal aspect, serving as a prized instrument for conducting comprehensive nucleic acid investigations. This extraordinary compound has played a crucial role in augmenting the realm of pharmaceutical transport mechanisms and diagnostic apparatuses.

CAT: BRP-02357

CAS: 210534-16-0

MF: C50H62F3N6O10P

MF: 995.03

Purity: 95%

Appearance: Off-white Solid

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InChIKey: XHGOWDJUVKONLU-HAKODNTASA-N

Solubility: Soluble in Anhydrous Acetonitrile, DMSO

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1CC(OC1COC(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)C4=CC=C(C=C4)OC)N5C=C(C(=O)NC5=O)C=CC(=O)NCCCCCCNC(=O)C(F)(F)F

IUPAC Name: (E)-3-[1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]-2,4-dioxopyrimidin-5-yl]-N-[6-[(2,2,2-trifluoroacetyl)amino]hexyl]prop-2-enamide

InChI: InChI=1S/C50H62F3N6O10P/c1-34(2)59(35(3)4)70(67-30-14-27-54)69-42-31-45(58-32-36(46(61)57-48(58)63)17-26-44(60)55-28-12-7-8-13-29-56-47(62)50(51,52)53)68-43(42)33-66-49(37-15-10-9-11-16-37,38-18-22-40(64-5)23-19-38)39-20-24-41(65-6)25-21-39/h9-11,15-26,32,34-35,42-43,45H,7-8,12-14,28-31,33H2,1-6H3,(H,55,60)(H,56,62)(H,57,61,63)/b26-17+/t42-,43+,45+,70?/m0/s1

Synonyms: Amino-modifier C6 dT CE Phosphoramidite; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-5-[(1E)-3-oxo-3-[[6-[(2,2,2-trifluoroacetyl)amino]hexyl]amino]-1-propen-1-yl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-2'-deoxy-5-[(1E)-3-oxo-3-({6-[(trifluoroacetyl)amino]hexyl}amino)-1-propen-1-yl]uridine; Amino-modifier C6 dT Phosphoramidite; Amino-Modifier C6 dT CEP

Biotin-dT CE-Phosphoramidite

Description: Biotin-dT CE-Phosphoramidite is a prestigious compound, engaged in the critical tasks of labeling and detecting DNA or RNA sequences. With the amalgamation of biotin, this meticulously modified nucleotide engenders a realm of convenience for meticulous purification processes, unrivaled amplification endeavors and captivating visualization techniques.

CAT: BRP-02358

CAS: 198080-40-9

MF: C69H89N8O12PS

MF: 1285.55

Purity: 95%

Appearance: White, off-white to light yellow powder

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InChIKey: FHABSPMZQJOPSS-GGVSAJPNSA-N

Solubility: Soluble in Anhydrous Acetonitrile

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1CC(OC1COC(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)C4=CC=C(C=C4)OC)N5C=C(C(=O)NC5=O)C=CC(=O)NCCCCCCNC(=O)CCCCC6C7C(CS6)N(C(=O)N7)C(=O)C8=CC=C(C=C8)C(C)(C)C

IUPAC Name: 5-[(3aR,6S,6aS)-3-(4-tert-butylbenzoyl)-2-oxo-3a,4,6,6a-tetrahydro-1H-thieno[3,4-d]imidazol-6-yl]-N-[6-[3-[1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]-2,4-dioxopyrimidin-5-yl]prop-2-enoylamino]hexyl]pentanamide

InChI: InChI=1S/C69H89N8O12PS/c1-46(2)77(47(3)4)90(87-41-19-38-70)89-57-42-62(88-58(57)44-86-69(51-20-13-12-14-21-51,52-29-33-54(84-8)34-30-52)53-31-35-55(85-9)36-32-53)75-43-49(64(80)74-66(75)82)26-37-61(79)72-40-18-11-10-17-39-71-60(78)23-16-15-22-59-63-56(45-91-59)76(67(83)73-63)65(81)48-24-27-50(28-25-48)68(5,6)7/h12-14,20-21,24-37,43,46-47,56-59,62-63H,10-11,15-19,22-23,39-42,44-45H2,1-9H3,(H,71,78)(H,72,79)(H,73,83)(H,74,80,82)/t56-,57-,58+,59-,62+,63-,90?/m0/s1

Synonyms: 5'-Dimethoxytrityloxy-5-[N-((4-t-butylbenzoyl)-biotinyl)-aminohexyl)-3-acrylimido]-2'-deoxyUridine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; Biotin-dT Amidite; Biotin-dT Phosphoramidite; (2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(5-(3-((6-(5-((3aS,4S,6aR)-1-(4-(tert-butyl)benzoyl)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)hexyl)amino)-3-oxoprop-1-en-1-yl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; 5'-O-DMTr-5-[N-((4-t-butylbenzoyl)-biotinyl)-aminohexyl)-3-acrylimido]-2'-dT-3'-CE-phosphoramidite; 5'-O-(4,4'-Dimethoxytrityl)-5-[N-((4-t-butylbenzoyl)-biotinyl)-aminohexyl)-3-acrylimido]-2'-deoxythymidine-3'-O-[(2-cyanoethyl)-N,N-diisopropyl]-phosphoramidite; Biotin-dT

FAM-xtra Phosphoramidite

Description: Oligonucleotides made from FAM-xtra phosphamide have considerable advantages over 6-FAM-labeled nucleotides.

CAT: BRP-02359

CAS: 2304636-67-5

MF: C46H56F2N3O10P

MF: 879.94

Purity: ≥95%

Appearance: White Solid

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InChIKey: LOTXQVJIDMUGJL-UHFFFAOYSA-N

CanonicalSMILES: N#CCCOP(OCCCCCCNC(=O)C1=CC=C2C(=O)OC3(C4=CC(F)=C(OC(=O)C(C)(C)C)C=C4OC5=CC(OC(=O)C(C)(C)C)=C(F)C=C53)C2=C1)N(C(C)C)C(C)C

IUPAC Name: 6-((6-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)hexyl)carbamoyl)-2',7'-difluoro-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-diyl bis(2,2-dimethylpropanoate)

InChI: InChI=1S/C46H56F2N3O10P/c1-27(2)51(28(3)4)62(57-21-15-18-49)56-20-14-12-11-13-19-50-40(52)29-16-17-30-31(22-29)46(61-41(30)53)32-23-34(47)38(59-42(54)44(5,6)7)25-36(32)58-37-26-39(35(48)24-33(37)46)60-43(55)45(8,9)10/h16-17,22-28H,11-15,19-21H2,1-10H3,(H,50,52)

Fluorescein II CEP

Description: Fluorescein II CEP is a derivative of fluorescein, which is used in many fluorescent tracers. It can be attached to certain bioactive molecules, thus allowing biologists to target fluorophores to specific proteins or structures within cells.

CAT: BRP-02360

CAS: 1027512-13-5

MF: C67H76N3O14P

MF: 1178.33

Purity: ≥95%

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Storage: Store at 2-8 °C

Boiling Point: 1063.4±65.0 °C (Predicted)

InChIKey: ZQNXVFAFTICSEX-UHFFFAOYSA-N

CanonicalSMILES: N#CCCOP(OC(COCCCNC(=O)C1=CC=C2C(=O)OC3(C4=CC=C(OC(=O)C(C)(C)C)C=C4OC5=CC(OC(=O)C(C)(C)C)=CC=C53)C2=C1)COC(C=6C=CC=CC6)(C7=CC=C(OC)C=C7)C8=CC=C(OC)C=C8)N(C(C)C)C(C)C

IUPAC Name: 6-((3-(3-(bis(4-methoxyphenyl)(phenyl)methoxy)-2-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)propoxy)propyl)carbamoyl)-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-diyl bis(2,2-dimethylpropanoate)

InChI: InChI=1S/C67H76N3O14P/c1-43(2)70(44(3)4)85(79-37-16-34-68)84-53(42-78-66(46-18-14-13-15-19-46,47-21-25-49(75-11)26-22-47)48-23-27-50(76-12)28-24-48)41-77-36-17-35-69-60(71)45-20-31-54-57(38-45)67(83-61(54)72)55-32-29-51(80-62(73)64(5,6)7)39-58(55)82-59-40-52(30-33-56(59)67)81-63(74)65(8,9)10/h13-15,18-33,38-40,43-44,53H,16-17,35-37,41-42H2,1-12H3,(H,69,71)

Synonyms: 6-Fluorescein CE Phosphoramidite; Propanoic acid, 2,2-dimethyl-, 1,1'-[6-[8-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-10-(2-cyanoethoxy)-12-methyl-11-(1-methylethyl)-1-oxo-6,9-dioxa-2,11-diaza-10-phosphatridec-1-yl]-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3',6'-diyl] ester; 1,1'-[6-[8-[[Bis(4-methoxyphenyl)phenylmethoxy]methyl]-10-(2-cyanoethoxy)-12-methyl-11-(1-methylethyl)-1-oxo-6,9-dioxa-2,11-diaza-10-phosphatridec-1-yl]-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3',6'-diyl] bis(2,2-dimethylpropanoate)

Dabcyl CE Phosphoramidite

Description: Dabcyl CE Phosphoramidite - the quintessential element for producing nucleotide probes. Its significance is pronounced in the life sciences industry due to its implementation in the creation of diagnostic assays that identify microbial and viral infections. It serves a pertinent role in sequencing DNA and researching cancer. Furthermore, it acts as a fluorophore in the development of real-time molecular assays contemplating the detection of diseases such as hepatitis C and HIV. Its optimal physiochemical attributes make it an exceptional reagent for oligonucleotide labeling and sequencing.

CAT: BRP-02361

MF: C52H65N6O6P

MF: 901.10

Purity: >95% by HPLC

Appearance: Yellow Solid

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IUPAC Name: (E)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-6-(4-((4-(dimethylamino)phenyl)diazenyl)benzamido)hexyl (2-cyanoethyl) diisopropylphosphoramidite