Phosphoramidites

Description: 2'-F-dC(Ac)-3'-Isopropyl Phosphoramidite is a modified deoxycytidine phosphoramidite used in oligonucleotide synthesis. The 2'-fluoro (2'-F) modification on the ribose sugar enhances the stability, nuclease resistance, and binding affinity of the resulting oligonucleotides. The cytosine base is protected with an acetyl (Ac) group at the N4 position to prevent side reactions during synthesis. The 3'-isopropyl phosphoramidite group allows for efficient incorporation into oligonucleotide chains during automated synthesis. This modification is particularly useful for applications requiring enhanced stability, resistance to enzymatic degradation, and improved hybridization properties, such as in therapeutic nucleic acids, antisense oligonucleotides, and RNA-based technologies.

CAT: BRP-02410

Molecular Formula: C41H52FN4O8P

Molecular Weight: 778.86

Purity: ≥95%

Description: 2'-F-dG(iBu)-3'-Isopropyl Phosphoramidite is a fluorinated guanosine phosphoramidite designed for oligonucleotide synthesis. It features a 2'-fluoro (2'-F) modification on the ribose sugar, which enhances the stability, nuclease resistance, and binding affinity of the resulting oligonucleotides. The guanine base is protected with an isobutyryl (iBu) group at the exocyclic amine, ensuring chemical stability and preventing side reactions during synthesis. The 3'-isopropyl phosphoramidite group facilitates efficient incorporation into oligonucleotide chains during automated synthesis. This modification is widely used in developing therapeutic nucleic acids, such as antisense oligonucleotides and siRNA, as well as in other applications requiring stable and bioactive oligonucleotides.

CAT: BRP-02411

Molecular Formula: C44H56FN6O8P

Molecular Weight: 846.94

Purity: ≥95%

Description: 2'-F-dU-3'-Isopropyl Phosphoramidite is a modified deoxyuridine phosphoramidite used in oligonucleotide synthesis. The 2'-fluoro (2'-F) modification on the ribose sugar enhances the stability, nuclease resistance, and binding affinity of the resulting oligonucleotides, making it more resistant to degradation by nucleases. The uracil base is left unmodified at the 5-position, providing standard pairing properties during hybridization. The 3'-isopropyl phosphoramidite group facilitates efficient incorporation into oligonucleotide chains during automated synthesis. This modification is particularly useful in applications requiring oligonucleotides with enhanced stability and resistance to enzymatic degradation, such as in antisense oligonucleotides, siRNA, and other RNA-based therapeutic strategies.

CAT: BRP-02412

Molecular Formula: C39H49FN3O8P

Molecular Weight: 737.81

Purity: ≥95%

Description: 2'-O-MOE-A(Bz)-3'-Isopropyl Phosphoramidite is a modified phosphoramidite used in oligonucleotide synthesis. It features a 2'-O-methoxyethyl (MOE) group on the ribose sugar, enhancing nuclease resistance, thermal stability, and hybridization affinity of the resulting oligonucleotides. The adenine base is protected with a benzoyl (Bz) group at the N6 position to ensure chemical stability and prevent side reactions during synthesis. The 3'-isopropyl phosphoramidite group allows for efficient and reliable incorporation into oligonucleotide chains via automated synthesis protocols. This modification is particularly beneficial for therapeutic applications, including antisense oligonucleotides and siRNA, where enhanced stability and improved performance are critical.

CAT: BRP-02413

Molecular Formula: C50H61N6O9P

Molecular Weight: 921.04

Purity: ≥95%

Description: 2'-O-MOE-5-Me-C(Bz)-3'-Isopropyl Phosphoramidite is a modified phosphoramidite designed for oligonucleotide synthesis. It features a 2'-O-methoxyethyl (MOE) group on the ribose sugar, which significantly enhances nuclease resistance, binding affinity, and thermal stability of the resulting oligonucleotides. The cytosine base is methylated at the 5-position (5-Me) to improve duplex stability and is protected with a benzoyl (Bz) group at the N4 position to prevent undesired side reactions during synthesis. The 3'-isopropyl phosphoramidite group ensures efficient incorporation into oligonucleotide chains during automated synthesis. This modification is particularly useful in therapeutic applications, including antisense oligonucleotides and siRNA, where enhanced stability, hybridization properties, and biological efficacy are critical.

CAT: BRP-02414

Molecular Formula: C50H63N4O10P

Molecular Weight: 911.05

Purity: ≥95%

Description: 2'-O-MOE-G(iBu)-3'-Isopropyl Phosphoramidite is a modified phosphoramidite used for oligonucleotide synthesis. It features a 2'-O-methoxyethyl (MOE) group on the ribose sugar, providing enhanced nuclease resistance, increased stability, and improved hybridization properties for the resulting oligonucleotides. The guanine base is protected with an isobutyryl (iBu) group at the exocyclic amine to prevent side reactions during synthesis. The 3'-isopropyl phosphoramidite group ensures efficient incorporation into oligonucleotide chains during automated synthesis. This modification is particularly valuable for the development of therapeutic nucleic acids, such as antisense oligonucleotides and siRNA, as well as in applications requiring highly stable and effective oligonucleotide structures.

CAT: BRP-02415

Molecular Formula: C47H63N6O10P

Molecular Weight: 903.03

Purity: ≥95%

Description: 2'-O-MOE-5-Me-U-3'-Isopropyl Phosphoramidite is a modified uridine phosphoramidite designed for oligonucleotide synthesis. It features a 2'-O-methoxyethyl (MOE) group on the ribose sugar, which significantly enhances the stability, nuclease resistance, and hybridization affinity of the resulting oligonucleotides. The uracil base is methylated at the 5-position (5-Me) to improve duplex stability and hybridization properties. The 3'-isopropyl phosphoramidite group facilitates efficient incorporation into oligonucleotide chains during automated synthesis. This modification is particularly useful for applications that require oligonucleotides with increased stability, resistance to enzymatic degradation, and improved biological activity, such as in antisense oligonucleotides, siRNA, and other RNA-based therapeutic technologies.

CAT: BRP-02416

Molecular Formula: C43H58N3O10P

Molecular Weight: 807.92

Purity: ≥95%

Description: 3'-O-MOE-5MeU-2'-Phosphoramidite is a modified uridine phosphoramidite designed for oligonucleotide synthesis. It features a 3'-O-methoxyethyl (MOE) group on the ribose sugar, which enhances nuclease resistance, stability, and hybridization affinity of the resulting oligonucleotides. Additionally, the uracil base is methylated at the 5-position (5MeU), further improving duplex stability and RNA-like properties. The 2'-phosphoramidite moiety enables efficient and controlled incorporation into oligonucleotide chains during synthesis. This phosphoramidite is particularly valuable in therapeutic oligonucleotides, including antisense technologies and RNA-targeting strategies, where improved stability, biological activity, and enhanced binding affinity are essential for efficacy.

CAT: BRP-02417

CAS: 256223-93-5

Molecular Formula: C43H55N4O10P

Molecular Weight: 818.89

Purity: ≥98%

Description: 2'-F-dC(Ac)-CE-Reverse Phosphoramidite is a modified cytidine phosphoramidite used in oligonucleotide synthesis, particularly for reverse direction incorporation. The 2'-fluoro (2'-F) modification on the ribose sugar enhances the stability and nuclease resistance of the resulting oligonucleotides. The acetyl (Ac) group at the N4 position of the cytosine base prevents side reactions during synthesis. The 3'-cyanoethyl (CE) phosphoramidite group at the 5'-position facilitates the reverse incorporation of nucleotides into the growing chain. This reverse phosphoramidite is ideal for constructing oligonucleotides with modified stability, such as in antisense oligonucleotides, siRNA, or other RNA-based therapeutics, where resistance to enzymatic degradation and improved hybridization characteristics are essential.

CAT: BRP-02418

Molecular Formula: C41H50N5O9P

Molecular Weight: 787.85

Purity: ≥98%

Appearance: White to off-white powder

Description: 2'-F-dG(iBu)-CE-Reverse Phosphoramidite is a modified deoxyguanosine phosphoramidite designed for reverse-direction incorporation during oligonucleotide synthesis. The 2'-fluoro (2'-F) modification on the ribose sugar increases the stability, nuclease resistance, and hybridization affinity of the resulting oligonucleotides. The isobutyryl (ibu) group at the N2 position of the guanine base provides protection to prevent unwanted side reactions during synthesis. The 3'-cyanoethyl (CE) phosphoramidite group at the 5'-position enables reverse incorporation, which is useful for synthesizing oligonucleotides with specialized structures, such as branched sequences or complex constructs. This reverse phosphoramidite is particularly beneficial for applications like antisense oligonucleotides and siRNA, where improved stability and resistance to degradation are crucial.

CAT: BRP-02419

CAS: 2757763-07-6

Molecular Formula: C44H53FN7O8P

Molecular Weight: 857.91

Purity: ≥98%

Appearance: White to off-white powder

Description: 2'-F-dU-CE-Reverse Phosphoramidite is a modified deoxyuridine phosphoramidite designed for reverse-direction oligonucleotide synthesis. The 2'-fluoro (2'-F) modification on the ribose sugar enhances the stability and nuclease resistance of the resulting oligonucleotides, improving their performance in biological applications. The 3'-cyanoethyl (CE) phosphoramidite group at the 5'-position allows for the incorporation of the nucleotide in the reverse direction (3'→5'). This feature is valuable for creating specialized oligonucleotide constructs, such as branched structures, probes, or sequences requiring reverse polarity. The deoxyuridine (dU) base remains unmodified at the 5-position, ensuring standard base-pairing during hybridization. This reverse phosphoramidite is particularly useful in applications like antisense oligonucleotides and RNA-based therapeutics, where enhanced stability and resistance to enzymatic degradation are critical.

CAT: BRP-02420

Molecular Formula: C39H47N4O9P

Molecular Weight: 746.80

Purity: ≥98%

Appearance: White to off-white powder

Description: 2'-O-MOE-5-Me-U Reverse Phosphoramidite is a modified uridine phosphoramidite used for reverse-direction oligonucleotide synthesis. It features a 2'-O-methoxyethyl (MOE) modification on the ribose sugar, which enhances the stability, nuclease resistance, and hybridization affinity of the resulting oligonucleotides. The 5-methyl (5-Me) modification on the uracil base further improves the stability of the oligonucleotide and mimics RNA-like behavior. The 3'-cyanoethyl (CE) phosphoramidite group at the 5'-position enables reverse incorporation of nucleotides (3'→5') into the oligonucleotide chain, making it suitable for the synthesis of specialized structures, such as branched sequences or complex constructs. This reverse phosphoramidite is particularly beneficial for therapeutic oligonucleotide applications, such as antisense oligonucleotides and RNA-based therapeutics, where enhanced stability, resistance to enzymatic degradation, and improved hybridization properties are essential.

CAT: BRP-02421

CAS: 1345715-43-6

Molecular Formula: C43H55N4O10P

Molecular Weight: 818.89

Purity: ≥98%

Appearance: White to off-white powder

Description: 2'-O-TBDMS-G(iBu)-CE-Reverse Phosphoramidite is a modified deoxyguanosine phosphoramidite used for reverse-direction oligonucleotide synthesis. It features a 2'-O-tert-butyldimethylsilyl (TBDMS) group on the ribose sugar, which acts as a protective group, shielding the 2'-hydroxyl group during synthesis and enhancing stability. The guanine (G) base is protected with an isobutyryl (iBu) group at the N2 position to prevent unwanted reactions during synthesis. The 3'-cyanoethyl (CE) phosphoramidite group at the 5'-position enables the reverse incorporation of nucleotides (3'→5') into the growing chain, which is essential for synthesizing oligonucleotides with specific structural requirements, such as branched or complex sequences. This reverse phosphoramidite is particularly useful in applications like antisense oligonucleotides, siRNA, and other RNA-based therapeutics, where improved stability, enzymatic resistance, and functionality are needed.

CAT: BRP-02422

CAS: 1214886-12-0

Molecular Formula: C50H68N7O9PSi

Molecular Weight: 970.18

Purity: ≥95%

Appearance: White to off-white powder

Description: 2'-O-MOE-U Reverse Phosphoramidite is a modified uridine phosphoramidite designed for reverse-direction oligonucleotide synthesis. It features a 2'-O-methoxyethyl (MOE) group on the ribose sugar, which significantly enhances the stability, nuclease resistance, and hybridization properties of the resulting oligonucleotides. The uracil (U) base remains unmodified, ensuring that the oligonucleotides retain their standard base-pairing properties. The 3'-cyanoethyl (CE) phosphoramidite group at the 5'-position facilitates reverse incorporation (3'→5') during synthesis, making this phosphoramidite ideal for constructing oligonucleotides with specialized structures, such as branched sequences or probes. This reverse phosphoramidite is particularly valuable in applications like antisense oligonucleotides, siRNA, and other RNA-based therapeutics, where improved stability, resistance to enzymatic degradation, and functionality are essential.

CAT: BRP-02423

Molecular Formula: C42H53N4O10P

Molecular Weight: 804.88

Purity: ≥95%

Appearance: White to off-white powder

Description: 3'-O-DMTr-2'-O-MOE-rC(Ac)-5'-CE-Phosphoramidite is a modified nucleoside phosphoramidite used in the synthesis of oligonucleotides with enhanced stability and functionality. It features a 3'-O-dimethoxytrityl (DMTr) protecting group on the 3'-hydroxyl of the ribose, which is commonly used to protect the 3'-OH group during the synthesis process. The 2'-O-methoxyethyl (MOE) modification on the ribose sugar enhances nuclease resistance, improves hybridization properties, and stabilizes the oligonucleotide in biological environments. The cytosine (rC) base is protected at the N4 position with an acetyl (Ac) group to prevent unwanted side reactions during synthesis. The 5'-cyanoethyl (CE) phosphoramidite group facilitates the incorporation of this modified nucleoside into the growing oligonucleotide chain. This phosphoramidite is particularly useful for constructing oligonucleotides with high stability, such as in antisense oligonucleotides, siRNA, or other RNA-based therapeutic applications, where resistance to enzymatic degradation and enhanced biological activity are key.

CAT: BRP-02424

Molecular Formula: C44H56N5O10P

Molecular Weight: 845.93

Purity: ≥95%

Appearance: White to off-white powder

Description: 3'-O-DMTr-2'-O-MOE-rC(Bz)-5'-CE-Phosphoramidite is a modified cytidine-based phosphoramidite used in the synthesis of stable oligonucleotides. It features a 3'-O-dimethoxytrityl (DMTr) protecting group, which safeguards the 3'-hydroxyl group during the chemical synthesis process. The 2'-O-methoxyethyl (MOE) modification enhances the nuclease resistance and hybridization properties of the oligonucleotide, providing improved stability in biological systems. The cytosine (rC) base is protected at the N4 position with a benzoyl (Bz) group to protect against side reactions during the synthesis. The 5'-cyanoethyl (CE) phosphoramidite group allows for efficient incorporation of the modified nucleoside into the growing oligonucleotide chain. This phosphoramidite is commonly used in the production of antisense oligonucleotides, siRNA, and other therapeutic RNA molecules, where high stability and resistance to enzymatic degradation are essential.

CAT: BRP-02425

Molecular Formula: C49H58N5O10P

Molecular Weight: 908.00

Purity: ≥95%

Appearance: White to off-white powder

Description: Diethyleneglycol ethyl ether phosphoramidite is a specialized phosphoramidite used in nucleic acid synthesis. It features a diethylene glycol ethyl ether group, which acts as a solubilizing and stabilizing agent, enhancing the overall stability and solubility of the phosphoramidite during oligonucleotide synthesis. The phosphoramidite functionality enables the efficient incorporation of this modification into the growing oligonucleotide chain. This phosphoramidite is typically used to introduce ethylene glycol-based linkers or modifications into oligonucleotides, providing increased flexibility, improved stability, or enhanced specific interaction properties for applications such as antisense therapy, gene silencing, or targeted drug delivery.

CAT: BRP-02426

CAS: 817620-31-8

Molecular Formula: C15H31N2O4P

Molecular Weight: 334.39

Purity: ≥97%

Appearance: White to off-white powder

Description: N-(2,3-dihydroxypropyl)-Octadecanamide Phosphoramidite is a modified phosphoramidite used in oligonucleotide synthesis. It contains an octadecanamide (C18) group, which is a fatty acid derivative, providing hydrophobicity and potential for increased binding affinity or stability in biological applications. The 2,3-dihydroxypropyl group, attached to the nitrogen of the amide, introduces a hydrophilic region that can improve the solubility and stability of the resulting oligonucleotide in aqueous environments. The phosphoramidite group facilitates the incorporation of this modification into the growing oligonucleotide chain. This type of phosphoramidite is useful for creating modified oligonucleotides with specific properties, such as improved cellular uptake or targeting capabilities, which can be particularly beneficial for therapeutic applications like gene silencing, antisense oligonucleotides, or RNA-based therapies.

CAT: BRP-02427

Molecular Formula: C51H78N3O6P

Molecular Weight: 860.17

Purity: ≥97%

Description: (E)-2-(4-(Sulfonyl)phenyl)-2-methylpropanoic acid linker is a chemical compound used in oligonucleotide synthesis, typically to introduce a specific functional group or to facilitate the attachment of oligonucleotides to various surfaces or biomolecules. The (E)-2 configuration refers to the geometric isomerism of the compound, ensuring that the sulfonyl group and the methylpropanoic acid chain are in the trans position, which can influence the compound's spatial arrangement and reactivity. The 4-(Sulfonyl)phenyl group provides a strong electron-withdrawing capability, often used to enhance the solubility and stability of the linker, as well as to facilitate selective binding interactions. The 2-methylpropanoic acid portion offers a site for further functionalization or conjugation, which is useful in creating modified oligonucleotides with specific properties such as improved binding affinity, stability, or targeting ability. This linker is particularly valuable in applications such as oligonucleotide conjugation to nanoparticles, antibodies, or other therapeutic agents, offering a versatile platform for drug delivery or targeted gene therapy.

CAT: BRP-02428

Molecular Formula: C46H57N4O8PS

Molecular Weight: 857.02

Purity: ≥95%

Description: 5'-O-DMT-2'-O-TBDMS-N6-(4-ethynylbenzoyl)-Adenosine 3'-CE Phosphoramidite is a specialized phosphoramidite used in the synthesis of oligonucleotides, incorporating multiple modifications for enhanced stability and functionalization. The 2'-O-tert-butyldimethylsilyl (TBDMS) group protects the 2'-hydroxyl group of the ribose, providing stability and preventing side reactions during oligonucleotide synthesis. This phosphoramidite is ideal for creating oligonucleotides with specific modifications for applications like drug delivery, targeting, or conjugation to other biomolecules, where chemical stability and the ability to form covalent links are important. The alkyne functionality provides flexibility in post-synthesis modifications, making this phosphoramidite useful in advanced research areas like bio-conjugation, molecular diagnostics, and RNA-based therapeutics.

CAT: BRP-02429

Molecular Formula: C55H66N7O8PSi

Molecular Weight: 1012.23

Purity: ≥98%