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2'-Modified Phosphoramidites
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PC Spacer Phosphoramidite (BRP-02212)
Description: PC Spacer phosphoramidite can be used as an intermediate to link any modification reagent (which can be used as phosphoramidite) to the end of the oligonucleotide. After light cleavage, 5'-phosphate is generated on the DNA, making it suitable for further biotransformation, such as gene construction and cloning after ligation.
CAT: BRP-02212
CAS: 653575-45-2
MF: C43H53N4O8P
MF: 784.88
Appearance: Off-white to yellow powder
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Storage: Store at -20 °C
Formulation: Dilute with anhydrous acetonitrile
InChIKey: KYVUUUIHEDGDBA-UHFFFAOYSA-N
CanonicalSMILES: N#CCCOP(OC(C1=CC(=CC=C1N(=O)=O)CNC(=O)CCCOC(C=2C=CC=CC2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)C)N(C(C)C)C(C)C
IUPAC Name: 1-(5-((4-(bis(4-methoxyphenyl)(phenyl)methoxy)butanamido)methyl)-2-nitrophenyl)ethyl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C43H53N4O8P/c1-31(2)46(32(3)4)56(54-28-12-26-44)55-33(5)40-29-34(16-25-41(40)47(49)50)30-45-42(48)15-11-27-53-43(35-13-9-8-10-14-35,36-17-21-38(51-6)22-18-36)37-19-23-39(52-7)24-20-37/h8-10,13-14,16-25,29,31-33H,11-12,15,27-28,30H2,1-7H3,(H,45,48)
Synonyms: [4-(4,4'-Dimethoxytrityloxy)butyramidomethyl)-1-(2-nitrophenyl)-ethyl]-2-cyanoethyl-(N,N-diisopropyl)-phosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 1-[5-[[[4-[bis(4-methoxyphenyl)phenylmethoxy]-1-oxobutyl]amino]methyl]-2-nitrophenyl]ethyl 2-cyanoethyl ester; 1-[5-[[[4-[Bis(4-methoxyphenyl)phenylmethoxy]-1-oxobutyl]amino]methyl]-2-nitrophenyl]ethyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, 1-[5-[[[4-[bis(4-methoxyphenyl)phenylmethoxy]-1-oxobutyl]amino]methyl]-2-nitrophenyl]ethyl 2-cyanoethyl ester
Biotin TEG Phosphoramidite (BRP-02214)
Description: Biotin TEG Phosphoramidite incorporates a biotin label with triethylene glycol spacer, either internally or at the 5' end of an oligonucleotide. Biotin is commonly used in detection systems in conjunction with streptavidin
CAT: BRP-02214
CAS: 198080-44-3
MF: C52H76N5O11PS
MF: 1010.24
Purity: ≥95% by NMR
Appearance: Off-white Solid
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Storage: Store at -20 °C
Boiling Point: 1018.0±65.0 °C at 760 mmHg
Symbol: BIOTIN-TEG CEP
Formulation: Dilute with anhydrous acetonitrile
InChIKey: JHOFQGWLXUQCDS-MPUKHDSVSA-N
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC(COCCOCCOCCOCCCNC(=O)CCCCC1C2C(CS1)NC(=O)N2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC
IUPAC Name: 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[3-[2-[2-[2-[3-[bis(4-methoxyphenyl)-phenylmethoxy]-2-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxypropoxy]ethoxy]ethoxy]ethoxy]propyl]pentanamide
InChI: InChI=1S/C52H76N5O11PS/c1-39(2)57(40(3)4)69(67-29-12-26-53)68-46(37-66-52(41-14-8-7-9-15-41,42-18-22-44(60-5)23-19-42)43-20-24-45(61-6)25-21-43)36-65-35-34-64-33-32-63-31-30-62-28-13-27-54-49(58)17-11-10-16-48-50-47(38-70-48)55-51(59)56-50/h7-9,14-15,18-25,39-40,46-48,50H,10-13,16-17,27-38H2,1-6H3,(H,54,58)(H2,55,56,59)/t46?,47-,48-,50-,69?/m0/s1
Synonyms: 1-Dimethoxytrityloxy-3-O-(N-biotinyl-3-aminopropyl)-triethyleneglycolyl-glyceryl-2-O-(2-cyanoethyl)-(N,N-diisopropyl)-phosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, 1-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-21-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-17-oxo-3,6,9,12-tetraoxa-16-azaheneicos-1-yl 2-cyanoethyl ester; Phosphoramidous acid, bis(1-methylethyl)-, 1-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-21-(hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl)-17-oxo-3,6,9,12-tetraoxa-16-azaheneicos-1-yl 2-cyanoethyl ester, [3aS-(3aα,4β,6aα)]-[partial]-; Biotin-TEG CEP; Biotin TEG amidite; Biotin TEG CE Phosphoramidite
10-O-[1-Propyl-3-N-carbamoylcholesteryl]-TEG-CE phosphoramidite (BRP-02215)
Description: 10-O-[1-Propyl-3-N-carbamoylcholesteryl]-TEG-CE phosphoramidite, an activator for viral RNA replication, is a specialized reagent used in the synthesis of modified oligonucleotides, particularly in the context of creating conjugated or functionalized nucleic acids. This reagent is particularly useful in the development of oligonucleotide-based drugs, where conjugation with lipophilic molecules like cholesterol can significantly improve the drug's performance.
CAT: BRP-02215
CAS: 1325147-19-0
MF: C46H82N3O7P
MF: 820.13
Purity: ≥95%
Appearance: Colorless oil to heavy oily matter
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Storage: Store at -20 °C
Boiling Point: 777.0±60.0 °C at 760 mmHg
InChIKey: XIXYNNLTICMGJD-CYNTUAGHSA-N
Solubility: Soluble in Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
CanonicalSMILES: CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)OC(=O)NCCCOCCOCCOCCOP(N(C(C)C)C(C)C)OCCC#N)C)C
IUPAC Name: [(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] N-[3-[2-[2-[2-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyethoxy]ethoxy]ethoxy]propyl]carbamate
InChI: InChI=1S/C46H82N3O7P/c1-34(2)13-10-14-37(7)41-17-18-42-40-16-15-38-33-39(19-21-45(38,8)43(40)20-22-46(41,42)9)56-44(50)48-24-12-25-51-27-28-52-29-30-53-31-32-55-57(54-26-11-23-47)49(35(3)4)36(5)6/h15,34-37,39-43H,10-14,16-22,24-33H2,1-9H3,(H,48,50)/t37-,39+,40+,41-,42+,43+,45+,46-,57?/m1/s1
Synonyms: 5'-Cholesterol-TEG-CE Phosphoramidite; 10-O-[1-Propyl-3-N-carbamoylcholesteryl]-triethyleneglycol-1-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; Cholest-5-en-3-ol (3β)-, 3-[16-[bis(1-methylethyl)amino]-19-cyano-6,9,12,15,17-pentaoxa-2-aza-16-phosphanonadecanoate]; 5'-Cholesteryl TEG phosphoramidite
5'-Amino-Modifier C12 (BRP-02216)
Description: 5'-Amino Modifier is designed for use in automatic synthesizers to functionalize the sequence of the 5'end of the target oligonucleotide. The use of trityl-protected amino-modifiers is recommended when purification is required prior to use.
CAT: BRP-02216
CAS: 178925-51-4
MF: C41H60N3O3P
MF: 673.92
Purity: >95%
Appearance: Light-yellow oily matter
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Storage: Store at -20 °C
Boiling Point: 687.7±55.0 °C at 760 mmHg
Formulation: Dilute with anhydrous acetonitrile
InChIKey: VJLVUDQTXLCFHR-UHFFFAOYSA-N
CanonicalSMILES: CC(C)N(C(C)C)P(OCCCCCCCCCCCCNC(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=C(C=C3)OC)OCCC#N
IUPAC Name: 3-[[di(propan-2-yl)amino]-[12-[[(4-methoxyphenyl)-diphenylmethyl]amino]dodecoxy]phosphanyl]oxypropanenitrile
InChI: InChI=1S/C41H60N3O3P/c1-35(2)44(36(3)4)48(47-34-22-31-42)46-33-21-13-11-9-7-6-8-10-12-20-32-43-41(37-23-16-14-17-24-37,38-25-18-15-19-26-38)39-27-29-40(45-5)30-28-39/h14-19,23-30,35-36,43H,6-13,20-22,32-34H2,1-5H3
Synonyms: 5'-Amino-Modifier C12-MMTr CE Phosphoramidite; 12-(4-Monomethoxytritylamino)dodecyl-1-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl 12-[[(4-methoxyphenyl)diphenylmethyl]amino]dodecyl ester; MMT-C12-amine-linker Phosphoramidite; Monomethoxytrityl-C12-hexylamine-linker Phosphoramidite; 5'-Amino-Modifier C12 Phosphoramidite; 2-Cyanoethyl 12-[[(4-methoxyphenyl)diphenylmethyl]amino]dodecyl N,N-bis(1-methylethyl)phosphoramidite
Biotin Phosphoramidite (BRP-02217)
Description: Biotin Phosphoramidite is a reagent used to incorporate biotin into oligonucleotides during solid-phase synthesis. The biotin moiety, known for its strong affinity to streptavidin, allows for easy detection, purification, and immobilization of the modified oligonucleotides. This makes it a valuable tool in molecular biology for labeling, assays, and targeted delivery applications. Biotinylated oligonucleotides are commonly used in techniques such as ELISA, Western blotting, and nucleic acid hybridization, providing a versatile and efficient way to enhance the functionality of DNA and RNA sequences.
CAT: BRP-02217
CAS: 1217500-22-5
MF: C46H64N5O8PS
MF: 878.07
Purity: ≥96%
Appearance: Off-white powder
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Storage: Store at -20 °C
Boiling Point: 954.5±65.0 °C at 760 mmHg
Formulation: Dilute with anhydrous acetonitrile
InChIKey: WSDQYLGSIUJJRU-ZMKGMYJVSA-N
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OCCOCCOCCNC(=O)CCCCC1C2C(CS1)N(C(=O)N2)C(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC
IUPAC Name: 5-[(3aR,6S,6aS)-3-[bis(4-methoxyphenyl)-phenylmethyl]-2-oxo-3a,4,6,6a-tetrahydro-1H-thieno[3,4-d]imidazol-6-yl]-N-[2-[2-[2-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyethoxy]ethoxy]ethyl]pentanamide
InChI: InChI=1S/C46H64N5O8PS/c1-34(2)51(35(3)4)60(58-27-12-25-47)59-32-31-57-30-29-56-28-26-48-43(52)16-11-10-15-42-44-41(33-61-42)50(45(53)49-44)46(36-13-8-7-9-14-36,37-17-21-39(54-5)22-18-37)38-19-23-40(55-6)24-20-38/h7-9,13-14,17-24,34-35,41-42,44H,10-12,15-16,26-33H2,1-6H3,(H,48,52)(H,49,53)/t41-,42-,44-,60?/m0/s1
Synonyms: 1-Dimethoxytrityloxy-2-(N-biotinyl-4-aminobutyl)-propyl-3-O-(2-cyanoethyl)-(N,N-diisopropyl)-phosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-[2-[2-[[5-[(3aS,4S,6aR)-1-[bis(4-methoxyphenyl)phenylmethyl]hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]ethoxy]ethoxy]ethyl 2-cyanoethyl ester; 2-[2-[2-[[5-[(3aS,4S,6aR)-1-[Bis(4-methoxyphenyl)phenylmethyl]hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]ethoxy]ethoxy]ethyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite; Biotin-amidite; DMTr-biotin-PEG3-(2-cyanoethyl) diisopropylphosphoramidite
5'-Biotin CE Phosphoramidite (BRP-02218)
Description: 5'-Biotin Phosphoramidite for direct labeling of synthetic oligonucleotides has the following characteristics:
- Soluble in acetonitrile at concentrations useful for DNA synthesis.
- Include the DMT group used for cassette purification, which is essential for the preparation of biotinylated PCR primers because cross-contamination may occur during HPLC purification.
- To develop diagnostic probes, biotin phosphoramidite can be branched to allow the introduction of multiple biotins at the 3'or 5'end.
CAT: BRP-02218
CAS: 135137-87-0
MF: C46H64N5O6PS
MF: 846.08
Purity: >95% by HPLC
Appearance: Off-white Solid
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Storage: Store at -20 °C
Boiling Point: 934.9±65.0 °C at 760 mmHg
Symbol: DMT-Biotin-C6 Amidite
Formulation: Dilute with anhydrous acetonitrile
InChIKey: RBXYKQBFPLXSJS-RYQQVEDISA-N
CanonicalSMILES: CC(C)N(C(C)C)P(OCCCCCCNC(=O)CCCCC1C2C(CS1)N(C(=O)N2)C(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OCCC#N
IUPAC Name: 5-[(3aR,6S,6aS)-3-[bis(4-methoxyphenyl)-phenylmethyl]-2-oxo-3a,4,6,6a-tetrahydro-1H-thieno[3,4-d]imidazol-6-yl]-N-[6-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyhexyl]pentanamide
InChI: InChI=1S/C46H64N5O6PS/c1-34(2)51(35(3)4)58(57-32-16-29-47)56-31-15-8-7-14-30-48-43(52)20-13-12-19-42-44-41(33-59-42)50(45(53)49-44)46(36-17-10-9-11-18-36,37-21-25-39(54-5)26-22-37)38-23-27-40(55-6)28-24-38/h9-11,17-18,21-28,34-35,41-42,44H,7-8,12-16,19-20,30-33H2,1-6H3,(H,48,52)(H,49,53)/t41-,42-,44-,58?/m0/s1
Synonyms: DMT-Biotin-C6 Phosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 6-[[5-[(3aS,4S,6aR)-1-[bis(4-methoxyphenyl)phenylmethyl]hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]hexyl 2-cyanoethyl ester; Phosphoramidous acid, bis(1-methylethyl)-, 6-[[5-[1-[bis(4-methoxyphenyl)phenylmethyl]hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]hexyl 2-cyanoethyl ester, [3aS-(3aα,4β,6aα)]-; 5'-Biotin Phosphoramidite; N1-(4,4'-Dimethoxytrityl)-biotinyl-6-aminohexyl]-2-cyanoethyl-(N,N-diisopropyl)-phosphoramidite
PC Biotin Phosphoramidite (BRP-02219)
Description: PC Biotin phosphoramidite can be used to prepare 5'-biotinylated oligonucleotides. After capturing the biotin-labeled DNA with streptavidin beads or attaching the modified DNA to the surface, the DNA can be released into the solution only by irradiating with a handheld ultraviolet light source.
CAT: BRP-02219
CAS: 853955-90-5
MF: C55H72N7O9PS
MF: 1038.25
Purity: >95%
Appearance: Light yellow solid
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Storage: Store at -20 °C
InChIKey: XSOZHGRMILVYEM-RNCGZCDESA-N
Solubility: Soluble in Anhydrous Acetonitrile
CanonicalSMILES: N#CCCOP(OC(C1=CC(=CC=C1N(=O)=O)CNC(=O)CCCCCNC(=O)CCCCC2SCC3N(C(=O)NC23)C(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C)N(C(C)C)C(C)C
IUPAC Name: 1-(5-((6-(5-((3aS,4S,6aR)-1-(bis(4-methoxyphenyl)(phenyl)methyl)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)hexanamido)methyl)-2-nitrophenyl)ethyl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C55H72N7O9PS/c1-38(2)61(39(3)4)72(70-34-16-32-56)71-40(5)47-35-41(22-31-48(47)62(66)67)36-58-52(64)20-12-9-15-33-57-51(63)21-14-13-19-50-53-49(37-73-50)60(54(65)59-53)55(42-17-10-8-11-18-42,43-23-27-45(68-6)28-24-43)44-25-29-46(69-7)30-26-44/h8,10-11,17-18,22-31,35,38-40,49-50,53H,9,12-16,19-21,33-34,36-37H2,1-7H3,(H,57,63)(H,58,64)(H,59,65)/t40?,49-,50-,53-,72?/m0/s1
Synonyms: 1-[2-Nitro-5-(6-(N-(4,4'-dimethoxytrityl))-biotinamidocaproamidomethyl)phenyl]-ethyl-[2-cyanoethyl-(N,N-diisopropyl)]-phosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, 1-[5-[[[6-[[5-[(3aS,4S,6aR)-1-[bis(4-methoxyphenyl)phenylmethyl]hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]-1-oxohexyl]amino]methyl]-2-nitrophenyl]ethyl 2-cyanoethyl ester
Phosphate-ON Phosphoramidite (BRP-02220)
Description: Phosphate-ON Phosphoramidite can be used to prepare 5'-phosphorylated oligonucleotides.
CAT: BRP-02220
CAS: 669013-14-3
MF: C49H62N7O11P
MF: 956.03
Purity: ≥96.0% (reversed phase HPLC)
Appearance: Solid
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Storage: Store at -20 °C
Symbol: Phosphate-ON amidite
InChIKey: MCGIOYZUTKDSIL-NNUNARBDSA-N
CanonicalSMILES: CC1=CN(C(=O)NC1=O)C2CC(C(O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OC(=O)NCCCNC(=O)CC(CC#N)OP(N(C(C)C)C(C)C)OCCC#N
IUPAC Name: [(2R,3S,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl] N-[3-[[(3R)-4-cyano-3-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxybutanoyl]amino]propyl]carbamate
InChI: InChI=1S/C49H62N7O11P/c1-33(2)56(34(3)4)68(64-28-11-24-50)67-41(23-25-51)29-44(57)52-26-12-27-53-48(60)66-42-30-45(55-31-35(5)46(58)54-47(55)59)65-43(42)32-63-49(36-13-9-8-10-14-36,37-15-19-39(61-6)20-16-37)38-17-21-40(62-7)22-18-38/h8-10,13-22,31,33-34,41-43,45H,11-12,23,26-30,32H2,1-7H3,(H,52,57)(H,53,60)(H,54,58,59)/t41-,42+,43-,45-,68?/m1/s1
Synonyms: (2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (3-((3R)-4-cyano-3-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)butanamido)propyl)carbamate; Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-[(9R)-11-[bis(1-methylethyl)amino]-14-cyano-9-(cyanomethyl)-7-oxo-10,12-dioxa-2,6-diaza-11-phosphatetradecanoate]
Amino-Modifier C6 dA (BRP-02221)
Description: Amino-Modifier C6 dA is designed for automatic synthesis. During oligonucleotide synthesis, the addition of the amino modifier dA can replace the dA residue to functionalize the target oligonucleotide.
CAT: BRP-02221
CAS: 1301170-09-1
MF: C55H65F3N9O8P
MF: 1068.14
Purity: ≥95%
Appearance: Crisp White Foam
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Storage: Store at 2-8 °C
InChIKey: GXRUEUPQLOMARL-QLBLUKILSA-N
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1CC(OC1COC(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)C4=CC=C(C=C4)OC)N5C6=NC=NC(=C6N=C5NCCCCCCNC(=O)C(F)(F)F)NC(=O)C7=CC=CC=C7
IUPAC Name: N-[9-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]-8-[6-[(2,2,2-trifluoroacetyl)amino]hexylamino]purin-6-yl]benzamide
InChI: InChI=1S/C55H65F3N9O8P/c1-37(2)67(38(3)4)76(73-33-17-30-59)75-45-34-47(74-46(45)35-72-54(40-20-13-10-14-21-40,41-22-26-43(70-5)27-23-41)42-24-28-44(71-6)29-25-42)66-50-48(49(62-36-63-50)65-51(68)39-18-11-9-12-19-39)64-53(66)61-32-16-8-7-15-31-60-52(69)55(56,57)58/h9-14,18-29,36-38,45-47H,7-8,15-17,31-35H2,1-6H3,(H,60,69)(H,61,64)(H,62,63,65,68)/t45-,46+,47+,76?/m0/s1
Synonyms: 5'-Dimethoxytrityl-N6-benzoyl-N8-[6-(trifluoroacetylamino)-hex-1-yl]-8-amino-2'-deoxyadenosine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-8-[[6-[(2,2,2-trifluoroacetyl)amino]hexyl]amino]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; 5'-DMTr-8-C6-linker-TFA-2'-deoxy-3'-O-CEP-adenosine; Amino Modifier C6-dA CE-Phosphoramidite
Amino-Modifier C6 dC (BRP-02222)
Description: Amino-Modifier C6 dC is designed for automatic synthesis. During oligonucleotide synthesis, the addition of the amino modifier dC can replace the dC residue to functionalize the target oligonucleotide.
CAT: BRP-02222
CAS: 853955-92-7
MF: C53H68F3N8O9P
MF: 1049.12
Purity: ≥95%
Appearance: Crisp white foam
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Storage: Store at 2-8 °C
InChIKey: BOZPQLMADZRBAJ-DDCNFULFSA-N
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1CC(OC1COC(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)C4=CC=C(C=C4)OC)N5C=C(C(=NC5=O)N=CN(C)C)C=CC(=O)NCCCCCCNC(=O)C(F)(F)F
IUPAC Name: 3-[1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]-4-(dimethylaminomethylideneamino)-2-oxopyrimidin-5-yl]-N-[6-[(2,2,2-trifluoroacetyl)amino]hexyl]prop-2-enamide
InChI: InChI=1S/C53H68F3N8O9P/c1-37(2)64(38(3)4)74(71-32-16-29-57)73-45-33-48(63-34-39(49(61-51(63)67)60-36-62(5)6)19-28-47(65)58-30-14-9-10-15-31-59-50(66)53(54,55)56)72-46(45)35-70-52(40-17-12-11-13-18-40,41-20-24-43(68-7)25-21-41)42-22-26-44(69-8)27-23-42/h11-13,17-28,34,36-38,45-46,48H,9-10,14-16,30-33,35H2,1-8H3,(H,58,65)(H,59,66)/t45-,46+,48+,74?/m0/s1
Synonyms: Amino-modifier-C6-dC Phosphoramidite; 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-2'-deoxy-N-[(dimethylamino)methylene]-5-[(1E)-3-oxo-3-({6-[(trifluoroacetyl)amino]hexyl}amino)-1-propen-1-yl]cytidine; 5'-Dimethoxytrityl-N-dimethylformamidine-5-[N-(trifluoroacetylaminohexyl)-3-acrylimido]-2'-deoxycytidine, 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; Amino-Modifier C6 dC CEP; Amino-modifier-C6-dC-CE-Phosphoramidite; Cytidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-[(dimethylamino)methylene]-5-[3-oxo-3-[[6-[(trifluoroacetyl)amino]hexyl]amino]-1-propenyl]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]
Amino-Modifier C6 dT (BRP-02223)
Description: Amino-Modifier C6 dT is designed for automatic synthesis. During oligonucleotide synthesis, the addition of the amino modifier dT can replace the dT residue to functionalize the target oligonucleotide.
CAT: BRP-02223
CAS: 178925-21-8
MF: C50H62N6O10F3P
MF: 995.05
Purity: ≥95%
Appearance: White to off-white powder
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Storage: Store at -20 °C, Keep in a dark and dry place
Formulation: Dilute with anhydrous acetonitrile
InChIKey: XHGOWDJUVKONLU-DCHZGMOKSA-N
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1CC(OC1COC(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)C4=CC=C(C=C4)OC)N5C=C(C(=O)NC5=O)C=CC(=O)NCCCCCCNC(=O)C(F)(F)F
IUPAC Name: 3-[1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]-2,4-dioxopyrimidin-5-yl]-N-[6-[(2,2,2-trifluoroacetyl)amino]hexyl]prop-2-enamid
InChI: InChI=1S/C50H62F3N6O10P/c1-34(2)59(35(3)4)70(67-30-14-27-54)69-42-31-45(58-32-36(46(61)57-48(58)63)17-26-44(60)55-28-12-7-8-13-29-56-47(62)50(51,52)53)68-43(42)33-66-49(37-15-10-9-11-16-37,38-18-22-40(64-5)23-19-38)39-20-24-41(65-6)25-21-39/h9-11,15-26,32,34-35,42-43,45H,7-8,12-14,28-31,33H2,1-6H3,(H,55,60)(H,56,62)(H,57,61,63)/t42-,43+,45+,70?/m0/s1
Synonyms: 5'-Dimethoxytrityl-5-[N-(trifluoroacetylaminohexyl)-3-acrylimido]-2'-deoxyuridine, 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-5-[3-oxo-3-[[6-[(2,2,2-trifluoroacetyl)amino]hexyl]amino]-1-propen-1-yl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-5-[3-oxo-3-[[6-[(trifluoroacetyl)amino]hexyl]amino]-1-propenyl]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; Trifluoroacetyl Amino-Modifier C6 dT
Related CAS: 210534-16-0 (E-isomer)
N2-Amino-Modifier C6 dG (BRP-02224)
Description: N2-Amino-Modifier C6 dG is designed for automatic synthesis. During oligonucleotide synthesis, the addition of the amino modifier dG can replace the dG residue to functionalize the target oligonucleotide.
CAT: BRP-02224
CAS: 1810776-99-8
MF: C48H60F3N8O8P
MF: 965.01
Purity: ≥95%
Appearance: Crisp Off-White Foam
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Storage: Store at 2-8 °C
InChIKey: LCMSIWHSYYDELA-AYXHSPLSSA-N
CanonicalSMILES: N#CCCOP(OC1CC(OC1COC(C=2C=CC=CC2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)N5C=NC=6C(=O)N=C(NC65)NCCCCCCNC(=O)C(F)(F)F)N(C(C)C)C(C)C
IUPAC Name: (2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(6-oxo-2-((6-(2,2,2-trifluoroacetamido)hexyl)amino)-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C48H60F3N8O8P/c1-32(2)59(33(3)4)68(65-28-14-25-52)67-39-29-41(58-31-55-42-43(58)56-46(57-44(42)60)54-27-13-8-7-12-26-53-45(61)48(49,50)51)66-40(39)30-64-47(34-15-10-9-11-16-34,35-17-21-37(62-5)22-18-35)36-19-23-38(63-6)24-20-36/h9-11,15-24,31-33,39-41H,7-8,12-14,26-30H2,1-6H3,(H,53,61)(H2,54,56,57,60)/t39-,40+,41+,68?/m0/s1
Synonyms: 5'-Dimethoxytrityl-N2-[6-(trifluoroacetylamino)-hex-1-yl]-2'-deoxyguanosine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-[6-[(2,2,2-trifluoroacetyl)amino]hexyl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
PC Amino-Modifier Phosphoramidite (BRP-02225)
Description: PC Amino-Modifier Phosphoramidite is can be incorporated into DNA and RNA with both phosphate and phosphorothioate linkages, used to prepare 5'-amino-modified oligonucleotides suitable for subsequent photocleavage.
CAT: BRP-02225
CAS: 732298-96-3
MF: C26H39F3N5O6P
MF: 605.59
Purity: ≥95%
Appearance: Colorless to light yellow oily matter
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Storage: Store at -20 °C
InChIKey: DSRDGAPERUUCRW-UHFFFAOYSA-N
Solubility: Soluble in Anhydrous Acetonitrile
CanonicalSMILES: N#CCCOP(OC(C1=CC(=CC=C1N(=O)=O)CNC(=O)CCCCCNC(=O)C(F)(F)F)C)N(C(C)C)C(C)C
IUPAC Name: 2-cyanoethyl (1-(2-nitro-5-((6-(2,2,2-trifluoroacetamido)hexanamido)methyl)phenyl)ethyl) diisopropylphosphoramidite
InChI: InChI=1S/C26H39F3N5O6P/c1-18(2)33(19(3)4)41(39-15-9-13-30)40-20(5)22-16-21(11-12-23(22)34(37)38)17-32-24(35)10-7-6-8-14-31-25(36)26(27,28)29/h11-12,16,18-20H,6-10,14-15,17H2,1-5H3,(H,31,36)(H,32,35)
Synonyms: Phosphoramidous acid, bis(1-methylethyl)-, 2-cyanoethyl 1-[2-nitro-5-[[[1-oxo-6-[(trifluoroacetyl)amino]hexyl]amino]methyl]phenyl]ethyl ester; [(6-Trifluoroacetylamidocaproamidomethyl)-1-(2-nitrophenyl)-ethyl]-2-cyanoethyl-(N,N-diisopropyl)-phosphoramidite; PC 5'-Amino modifier-CE-Phoshoramidite
Thiol-Modifier C6 S-S (BRP-02226)
Description: Thiol-Modifier C6 S-S incorporates a thiol reactive functional group for conjugation. This disulphide product can also be used to modify the 3'-position by using the phosphoramidite as the first adduct in the oligo sequence.
CAT: BRP-02226
CAS: 148254-21-1
MF: C42H61N2O5S2P
MF: 769.05
Purity: >95% by HPLC
Appearance: Colorless oily matter
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Storage: Store at -20 °C
Boiling Point: 757.4±60.0 °C at 760 mmHg
InChIKey: VEONRKLBSGQZRU-UHFFFAOYSA-N
CanonicalSMILES: CC(C)N(C(C)C)P(OCCCCCCSSCCCCCCOC(C1=CC=CC=C1)(C2=CC=C(C=C2)OC)C3=CC=C(C=C3)OC)OCCC#N
IUPAC Name: 3-[6-[6-[bis(4-methoxyphenyl)-phenylmethoxy]hexyldisulfanyl]hexoxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
InChI: InChI=1S/C42H61N2O5PS2/c1-35(2)44(36(3)4)50(49-32-18-29-43)48-31-15-8-10-17-34-52-51-33-16-9-7-14-30-47-42(37-19-12-11-13-20-37,38-21-25-40(45-5)26-22-38)39-23-27-41(46-6)28-24-39/h11-13,19-28,35-36H,7-10,14-18,30-34H2,1-6H3
Synonyms: 1-O-Dimethoxytrityl-hexyl-disulfide, 1'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; Thiol-Modifier C6 S-S CE Phosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 6-[[6-[bis(4-methoxyphenyl)phenylmethoxy]hexyl]dithio]hexyl 2-cyanoethyl ester; N,N-Bis(1-methylethyl)phosphoramidous Acid [[6-[Bis(4-methoxyphenyl)phenylmethoxy]hexyl]dithio]hexyl 2-Cyanoethylester; 6-[[6-[Bis(4-methoxyphenyl)phenylmethoxy]hexyl]dithio]hexyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite
5'-(5-Fluorescein) phosphoramidite (BRP-02227)
Description: 5'-(5-Fluorescein) phosphoramidite is a reagent used in the synthesis of fluorescently labeled oligonucleotides. FAM (Fluorescein Amidite) is a fluorescent dye, and the 5-isomer refers to the specific structural form of FAM that is commonly used for labeling. It is a key reagent for researchers needing to create fluorescently labeled DNA or RNA for various diagnostic, research, and analytical applications.
CAT: BRP-02227
CAS: 147566-42-5
MF: C46H58N3O10P
MF: 843.94
Purity: >95%
Appearance: White to off-white solid
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Storage: Store at -20 °C
Boiling Point: 844.7±65.0 °C at 760 mmHg
Symbol: 5-FAM
InChIKey: XUQUNBOKLNVMMK-UHFFFAOYSA-N
Fluorescence Maximum: 517
Absorption Maximum (Lambda Max): 492
Solubility: Soluble in Acetonitrile, DCM
CanonicalSMILES: CC(C)N(C(C)C)P(OCCCCCCNC(=O)C1=CC2=C(C=C1)C3(C4=C(C=C(C=C4)OC(=O)C(C)(C)C)OC5=C3C=CC(=C5)OC(=O)C(C)(C)C)OC2=O)OCCC#N
IUPAC Name: [5-[6-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyhexylcarbamoyl]-6'-(2,2-dimethylpropanoyloxy)-3-oxospiro[2-benzofuran-1,9'-xanthene]-3'-yl] 2,2-dimethylpropanoate
InChI: InChI=1S/C46H58N3O10P/c1-29(2)49(30(3)4)60(55-25-15-22-47)54-24-14-12-11-13-23-48-40(50)31-16-19-35-34(26-31)41(51)59-46(35)36-20-17-32(56-42(52)44(5,6)7)27-38(36)58-39-28-33(18-21-37(39)46)57-43(53)45(8,9)10/h16-21,26-30H,11-15,23-25H2,1-10H3,(H,48,50)
Synonyms: 5-FAM phosphoramidite; 5-Fluorescein Phosphoramidite; 5'(5)-FAM; 5'-5-Fluorescein phosphoramidite; FAM Phosphoramidite, 5-Isomer; Propanoic acid, 2,2-dimethyl-, 5-[10-[bis(1-methylethyl)amino]-13-cyano-1-oxo-9,11-dioxa-2-aza-10-phosphatridec-1-yl]-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3',6'-diyl ester; Fluorescein Phosphoramidite
5'-Dabcyl Phosphoramidite (BRP-02229)
Description: 5'-Dabcyl Phosphoramidite is an oligonucleotide probe with a dark quencher Dabcyl-5' locating at the 5'-end.
CAT: BRP-02229
CAS: 288631-58-3
MF: C30H45N6O3P
MF: 568.69
Purity: >95%
Appearance: Sticky orange solid
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Storage: Store at -20 °C
Boiling Point: 680.0±55.0 °C at 760 mmHg
Symbol: 5'-DABCYL CEP
Formulation: Dilute with anhydrous acetonitrile
InChIKey: RBMLVVGBOLZOAB-UHFFFAOYSA-N
CanonicalSMILES: CC(C)N(C(C)C)P(OCCCCCCNC(=O)C1=CC=C(C=C1)N=NC2=CC=C(C=C2)N(C)C)OCCC#N
IUPAC Name: N-[6-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyhexyl]-4-[[4-(dimethylamino)phenyl]diazenyl]benzamide
InChI: InChI=1S/C30H45N6O3P/c1-24(2)36(25(3)4)40(39-23-11-20-31)38-22-10-8-7-9-21-32-30(37)26-12-14-27(15-13-26)33-34-28-16-18-29(19-17-28)35(5)6/h12-19,24-25H,7-11,21-23H2,1-6H3,(H,32,37)
Synonyms: 5'-DABCYL CEP; 6-(N-4'-carboxy-4-(dimethylamino)azobenzene)-aminohexyl-1-O-(2-cyanoethyl)-(N,N-diisopropyl)-phosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, 2-cyanoethyl 6-[[4-[[4-(dimethylamino)phenyl]azo]benzoyl]amino]hexyl ester; 2-cyanoethyl (6-(4-((4-(dimethylamino)phenyl)diazenyl)benzamido)hexyl) diisopropylphosphoramidite
6-SIMA phosphoramidite (BRP-02230)
Description: SIMA is an analog of HEX with improved stability. 6-SIMA phosphoramidite is a fluorescent dye for oligonucleotide labeling.
CAT: BRP-02230
CAS: 1411797-05-1
MF: C58H64Cl2N3O10P
MF: 1065.02
Purity: >95%
Appearance: White powder
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Storage: Store at -20 °C
Boiling Point: 984.6±65.0 °C at 760 mmHg
Formulation: Dilute with anhydrous acetonitrile
InChIKey: WPCMEEMVKXSQGE-UHFFFAOYSA-N
Fluorescence Maximum: 555
Absorption Maximum (Lambda Max): 531
Solubility: Soluble in Acetonitrile, DCM
CanonicalSMILES: CC(C)N(C(C)C)P(OCCCCCCNC(=O)C1=CC(=C2C(=C1Cl)C3(C4=C(C=C(C(=C4)C5=CC=CC=C5)OC(=O)C(C)(C)C)OC6=C3C=C(C(=C6)OC(=O)C(C)(C)C)C7=CC=CC=C7)OC2=O)Cl)OCCC#N
IUPAC Name: [4,7-dichloro-6-[6-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyhexylcarbamoyl]-6'-(2,2-dimethylpropanoyloxy)-3-oxo-2',7'-diphenylspiro[2-benzofuran-1,9'-xanthene]-3'-yl] 2,2-dimethylpropanoate
InChI: InChI=1S/C58H64Cl2N3O10P/c1-35(2)63(36(3)4)74(69-29-21-26-61)68-28-20-12-11-19-27-62-52(64)41-32-44(59)49-50(51(41)60)58(73-53(49)65)42-30-39(37-22-15-13-16-23-37)45(71-54(66)56(5,6)7)33-47(42)70-48-34-46(72-55(67)57(8,9)10)40(31-43(48)58)38-24-17-14-18-25-38/h13-18,22-25,30-36H,11-12,19-21,27-29H2,1-10H3,(H,62,64)
Synonyms: SIMA phosphoramidite, 6-isomer; [(3',6'-dipivaloyl-2',7'-diphenyl-4,7-dichlorofluoresceinyl)-6-carboxamidohexyl]-1-O-(2-cyanoethyl)-(N,N-diisopropyl)-phosphoramidite; Propanoic acid, 2,2-dimethyl-, 1,1'-[6-[10-[bis(1-methylethyl)amino]-13-cyano-1-oxo-9,11-dioxa-2-aza-10-phosphatridec-1-yl]-4,7-dichloro-3-oxo-2',7'-diphenylspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3',6'-diyl] ester; 1,1'-[6-[10-[Bis(1-methylethyl)amino]-13-cyano-1-oxo-9,11-dioxa-2-aza-10-phosphatridec-1-yl]-4,7-dichloro-3-oxo-2',7'-diphenylspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3',6'-diyl] bis(2,2-dimethylpropanoate); SIMA
Fluorescein 2'-deoxy-5'-O-DMT-pseudouridine 3'-CE phosphoramidite (BRP-02231)
Description: It is a remarkable compound showcasing its unparalleled potency in targeting and studying a wide range of (mention the specific diseases) through its unique mechanism of action.
CAT: BRP-02231
CAS: 289712-99-8
MF: C79H89N6O17P
MF: 1425.57
Purity: ≥95%
Appearance: Off-white powder
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Storage: Store at 2-8 °C
InChIKey: WHVKLEUMJJAXRZ-PCLSEREPSA-N
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1CC(OC1COC(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)C4=CC=C(C=C4)OC)C5=CN(C(=O)NC5=O)C=CC(=O)NCCCCCCNC(=O)C6=CC7=C(C=C6)C8(C9=C(C=C(C=C9)OC(=O)C(C)(C)C)OC1=C8C=CC(=C1)OC(=O)C(C)(C)C)OC7=O
IUPAC Name: [5-[6-[3-[5-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]-2,4-dioxopyrimidin-1-yl]prop-2-enoylamino]hexylcarbamoyl]-6'-(2,2-dimethylpropanoyloxy)-3-oxospiro[2-benzofuran-1,9'-xanthene]-3'-yl] 2,2-dimethylpropanoate
InChI: InChI=1S/C79H89N6O17P/c1-49(2)85(50(3)4)103(96-42-20-38-80)102-67-46-64(99-68(67)48-95-78(52-21-16-15-17-22-52,53-24-28-55(93-11)29-25-53)54-26-30-56(94-12)31-27-54)60-47-84(75(92)83-71(60)88)41-37-69(86)81-39-18-13-14-19-40-82-70(87)51-23-34-61-59(43-51)72(89)101-79(61)62-35-32-57(97-73(90)76(5,6)7)44-65(62)100-66-45-58(33-36-63(66)79)98-74(91)77(8,9)10/h15-17,21-37,41,43-45,47,49-50,64,67-68H,13-14,18-20,39-40,42,46,48H2,1-12H3,(H,81,86)(H,82,87)(H,83,88,92)/t64-,67+,68-,103?/m1/s1
Synonyms: Propanoic acid, 2,2-dimethyl-, 5-[[[6-[[3-[5-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-deoxy-β-D-erythro-pentofuranosyl]-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl]-1-oxo-2-propenyl]amino]hexyl]amino]carbonyl]-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3',6'-diyl ester; Fluorescein-deoxy-pU Phosphoramidite; Fluorescein 5-methyl-2'-deoxy-5'-O-DMT-pseudouridine 3'-CE phosphoramidite; 6-Fluorescein 5-methyl-2'-deoxy-5'-O-DMT-pseudouridine 3'-CE phosphoramidite
Related CAS: 1194507-30-6 (6-Fluorescein dT phosphoramidite)
5-SIMA phosphoramidite (BRP-02232)
Description: SIMA is an analog of HEX with improved stability. 5-SIMA phosphoramidite is a fluorescent dye for oligonucleotide labeling.
CAT: BRP-02232
MF: C58H64Cl2N3O10P
MF: 1065.02
Purity: >95%
Appearance: Soild
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Storage: Store at -20 °C
Formulation: Dilute with anhydrous acetonitrile
InChIKey: DRMXDUCOFIXGTJ-UHFFFAOYSA-N
IUPAC Name: 4,7-dichloro-5-((6-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)hexyl)carbamoyl)-3-oxo-2',7'-diphenyl-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-diyl bis(2,2-dimethylpropanoate)
InChI: InChI=1S/C58H64Cl2N3O10P/c1-35(2)63(36(3)4)74(69-29-21-26-61)68-28-20-12-11-19-27-62-52(64)41-32-44(59)50-49(51(41)60)53(65)73-58(50)42-30-39(37-22-15-13-16-23-37)45(71-54(66)56(5,6)7)33-47(42)70-48-34-46(72-55(67)57(8,9)10)40(31-43(48)58)38-24-17-14-18-25-38/h13-18,22-25,30-36H,11-12,19-21,27-29H2,1-10H3,(H,62,64)
6-Tetrachloro-Fluorescein Phosphoramidite (BRP-02233)
Description: 6-Tetrachloro-Fluorescein Phosphoramidite is a fluorescent dye used for oligonucleotide labeling.
CAT: BRP-02233
CAS: 877049-90-6
MF: C46H54N3O10Cl4P
MF: 981.72
Purity: ≥95%
Appearance: White to off-white powder
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Storage: Store at -20 °C
Boiling Point: 895.1±65.0 °C at 760 mmHg
Symbol: 6-TET Phosphoramidite; 5'-Tetrachloro-Fluorescein-CE Phosphoramidite (TET)
InChIKey: RKVIHIDUTMZQEZ-UHFFFAOYSA-N
CanonicalSMILES: CC(C)N(C(C)C)P(OCCCCCCNC(=O)C1=CC(=C2C(=C1Cl)C3(C4=CC(=C(C=C4OC5=CC(=C(C=C53)Cl)OC(=O)C(C)(C)C)OC(=O)C(C)(C)C)Cl)OC2=O)Cl)OCCC#N
IUPAC Name: [2',4,7,7'-tetrachloro-6-[6-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyhexylcarbamoyl]-6'-(2,2-dimethylpropanoyloxy)-3-oxospiro[2-benzofuran-1,9'-xanthene]-3'-yl] 2,2-dimethylpropanoate
InChI: InChI=1S/C46H54Cl4N3O10P/c1-25(2)53(26(3)4)64(59-19-15-16-51)58-18-14-12-11-13-17-52-40(54)27-20-32(49)37-38(39(27)50)46(63-41(37)55)28-21-30(47)35(61-42(56)44(5,6)7)23-33(28)60-34-24-36(31(48)22-29(34)46)62-43(57)45(8,9)10/h20-26H,11-15,17-19H2,1-10H3,(H,52,54)
Synonyms: DyLight TET CEP; Propanoic acid, 2,2-dimethyl-, 6-[10-[bis(1-methylethyl)amino]-13-cyano-1-oxo-9,11-dioxa-2-aza-10-phosphatridec-1-yl]-2',4,7,7'-tetrachloro-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3',6'-diyl ester; 6-TET Phosphoramidite; TET phosphoramidite, 6-isomer; 6-(4,7,2',7'-Tetrachloro-3',6'-dipivaloylfluoresceinyl-6-carboxamido)-hexyl-1-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
