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10-O-[1-Propyl-3-N-carbamoylcholesteryl]-TEG-CE phosphoramidite
10-O-[1-Propyl-3-N-carbamoylcholesteryl]-TEG-CE phosphoramidite, an activator for viral RNA replication, is a specialized reagent used in the synthesis of modified oligonucleotides, particularly in the context of creating conjugated or functionalized nucleic acids. This reagent is particularly useful in the development of oligonucleotide-based drugs, where conjugation with lipophilic molecules like cholesterol can significantly improve the drug's performance.
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Catalog
BRP-02215
Synonyms
5'-Cholesterol-TEG-CE Phosphoramidite; 10-O-[1-Propyl-3-N-carbamoylcholesteryl]-triethyleneglycol-1-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; Cholest-5-en-3-ol (3β)-, 3-[16-[bis(1-methylethyl)amino]-19-cyano-6,9,12,15,17-pentaoxa-2-aza-16-phosphanonadecanoate]; 5'-Cholesteryl TEG phosphoramidite
CAS
1325147-19-0
IUPAC Name
[(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] N-[3-[2-[2-[2-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyethoxy]ethoxy]ethoxy]propyl]carbamate
Molecular Weight
820.13
Molecular Formula
C46H82N3O7P
Canonical SMILES
CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)OC(=O)NCCCOCCOCCOCCOP(N(C(C)C)C(C)C)OCCC#N)C)C
InChI
InChI=1S/C46H82N3O7P/c1-34(2)13-10-14-37(7)41-17-18-42-40-16-15-38-33-39(19-21-45(38,8)43(40)20-22-46(41,42)9)56-44(50)48-24-12-25-51-27-28-52-29-30-53-31-32-55-57(54-26-11-23-47)49(35(3)4)36(5)6/h15,34-37,39-43H,10-14,16-22,24-33H2,1-9H3,(H,48,50)/t37-,39+,40+,41-,42+,43+,45+,46-,57?/m1/s1
InChIKey
XIXYNNLTICMGJD-CYNTUAGHSA-N
Boiling Point
777.0±60.0 °C at 760 mmHg
Purity
≥95%
Solubility
Soluble in Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
Appearance
Colorless oil to heavy oily matter
Storage
Store at -20 °C
Chemical Structure:
