Phosphoramidites - RNA / BOC Sciences

Dabcyl CE Phosphoramidite

Description: Dabcyl CE Phosphoramidite - the quintessential element for producing nucleotide probes. Its significance is pronounced in the life sciences industry due to its implementation in the creation of diagnostic assays that identify microbial and viral infections. It serves a pertinent role in sequencing DNA and researching cancer. Furthermore, it acts as a fluorophore in the development of real-time molecular assays contemplating the detection of diseases such as hepatitis C and HIV. Its optimal physiochemical attributes make it an exceptional reagent for oligonucleotide labeling and sequencing.

CAT: BRP-02361

MF: C52H65N6O6P

MF: 901.10

Purity: >95% by HPLC

Appearance: Yellow Solid

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IUPAC Name: (E)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-6-(4-((4-(dimethylamino)phenyl)diazenyl)benzamido)hexyl (2-cyanoethyl) diisopropylphosphoramidite

DMTr-TNA-U amidite

Description: DMTr-TNA-U amidite is a phosphoramidite monomer used in the RNA synthesis.

CAT: BRP-02366

CAS: 325683-95-2

MF: C38H45N4O8P

MF: 716.76

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InChIKey: CTMYNQLRHZTTLF-YPQZKSMWSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(COC1N2C=CC(=O)NC2=O)OC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: 3-[[(2R,3R,4S)-4-[bis(4-methoxyphenyl)-phenylmethoxy]-2-(2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C38H45N4O8P/c1-26(2)42(27(3)4)51(48-24-10-22-39)50-35-33(25-47-36(35)41-23-21-34(43)40-37(41)44)49-38(28-11-8-7-9-12-28,29-13-17-31(45-5)18-14-29)30-15-19-32(46-6)20-16-30/h7-9,11-21,23,26-27,33,35-36H,10,24-25H2,1-6H3,(H,40,43,44)/t33-,35+,36+,51?/m0/s1

Synonyms: TNA-U CE-Phosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, (2R,3R,4S)-4-[bis(4-methoxyphenyl)phenylmethoxy]-2-(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)tetrahydro-3-furanyl 2-cyanoethyl ester; (2R,3R,4S)-4-(Bis(4-methoxyphenyl)(phenyl)methoxy)-2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; DMTr-TNA-U-Phosphoramidite

GalNAc-NAG-25 Phosphoramidite

Description: GalNAc-NAG-25 Phosphoramidite is a modified phosphoramidite that incorporates a N-acetylgalactosamine (GalNAc) moiety linked to the NAG component, specifically designed for the synthesis of oligonucleotides. This compound enhances the stability and bioactivity of nucleic acids, particularly in applications involving targeted delivery and therapeutic interventions. Its unique structural features allow for improved interactions with cellular receptors, making GalNAc-NAG-25 Phosphoramidite valuable in the development of glyco-engineered therapeutics and in the field of glycobiology, where carbohydrate-based modifications play a crucial role in biological processes.

CAT: BRP-02368

MF: C88H145N10O43P

MF: 2062.13

Purity: ≥95%

Appearance: White to light yellow powder

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InChIKey: GTRPVVVEZDWBLA-ODUHJEIDSA-N

CanonicalSMILES: O=C(C)O[C@@H]([C@H]1OC(C)=O)[C@H]([C@@H](O[C@@H]1COC(C)=O)OCCOCCNC(CC[C@@H](C(NCCOCCO[C@@H]([C@@H]([C@H]([C@H]2OC(C)=O)OC(C)=O)NC(C)=O)O[C@@H]2COC(C)=O)=O)NC(CC[C@@H](C(NCCOCCO[C@@H]3O[C@@H]([C@@H]([C@@H]([C@H]3NC(C)=O)OC(C)=O)OC(C)=O)COC(C)=O)=O)NC(CCOCCOCCOCCOCCOCCOCCOP(N(C(C)C)C(C)C)OCCC#N)=O)=O)=O)NC(C)=O

InChI: InChI=1S/C88H145N10O43P/c1-53(2)98(54(3)4)142(131-27-17-23-89)132-49-45-124-41-40-123-39-38-122-37-36-121-35-34-120-33-32-116-28-22-74(113)97-68(85(115)92-26-31-119-44-48-127-88-77(95-57(7)101)83(138-66(16)110)80(135-63(13)107)71(141-88)52-130-60(10)104)19-21-73(112)96-67(84(114)91-25-30-118-43-47-126-87-76(94-56(6)100)82(137-65(15)109)79(134-62(12)106)70(140-87)51-129-59(9)103)18-20-72(111)90-24-29-117-42-46-125-86-75(93-55(5)99)81(136-64(14)108)78(133-61(11)105)69(139-86)50-128-58(8)102/h53-54,67-71,75-83,86-88H,17-22,24-52H2,1-16H3,(H,90,111)(H,91,114)(H,92,115)(H,93,99)(H,94,100)(H,95,101)(H,96,112)(H,97,113)/t67-,68-,69+,70+,71+,75+,76+,77+,78-,79-,80-,81+,82+,83+,86+,87+,88+,142?/m0/s1

Synonyms: NAG-25; GalNAc NAG-25 Phosphoramidite

5'-(E)-VP-2'-F-U-CE-Phoshoramidite

Description: 5'-(E)-VP-2'-F-U-Phosphoramidite is a chemical reagent used in the synthesis of oligonucleotides. It features a 5' end with a trans configuration, incorporating 2'-fluorouridine (2'-F-U) and a CE group, which enhances synthesis efficiency and stability. This compound is widely utilized in nucleic acid chemistry and biotechnology, particularly in gene engineering and drug development.

CAT: BRP-02369

MF: C31H49FN4O12P2

MF: 750.69

Purity: ≥95%

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InChIKey: JWXATAHHGRKVNU-JUJRXIDKSA-N

CanonicalSMILES: F[C@@H]1[C@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](/C=C/P(OCOC(C(C)(C)C)=O)(OCOC(C(C)(C)C)=O)=O)O[C@H]1N2C(NC(C=C2)=O)=O

IUPAC Name: ((((E)-2-((2R,3R,4R,5R)-3-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluorotetrahydrofuran-2-yl)vinyl)phosphoryl)bis(oxy))bis(methylene) bis(2,2-dimethylpropanoate)

InChI: InChI=1S/C31H49FN4O12P2/c1-20(2)36(21(3)4)49(44-16-11-14-33)48-25-22(47-26(24(25)32)35-15-12-23(37)34-29(35)40)13-17-50(41,45-18-42-27(38)30(5,6)7)46-19-43-28(39)31(8,9)10/h12-13,15,17,20-22,24-26H,11,16,18-19H2,1-10H3,(H,34,37,40)/b17-13+/t22-,24-,25-,26-,49?/m1/s1

Synonyms: 5'(E)-VP-2'-F-U-CE-Phoshoramidite; 5'-(E)-VP-2'-deoxy-2'-F-U-CE-Phoshoramidite; 5'-POM-(E)-vinyl phosphonate-2'-deoxy-2'-fluoro-U-3'-CE-Phosphoramidite; 5'-(E)-VP-2'-F-U Phosphoramidite

5'-(Z)-VP-2'-F-2'-Me-U-CE-Phoshoramidite

Description: 5'-(Z)-VP-2'-F-2'-Me-U-Phosphoramidite is a specialized chemical reagent designed for the synthesis of oligonucleotides. This compound features a 5' end with a cis configuration, incorporating 2'-fluoro-2'-methyluridine (2'-F-2'-Me-U) along with a CE group. The modifications enhance the stability and efficiency of the synthesis process, making it particularly valuable in nucleic acid research, gene therapy, and drug development. Its unique structural properties allow for improved interactions and functionality in various biotechnological applications.

CAT: BRP-02370

CAS: 2923487-59-4

MF: C32H51FN4O12P2

MF: 764.71

Purity: ≥95%

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InChIKey: AKBGYKGPJKZIJW-OHBQVFRMSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=CC(=O)NC2=O)C1(F)C)C=CP(=O)(OCOC(=O)C(C)(C)C)OCOC(=O)C(C)(C)C)N(C(C)C)C(C)C

IUPAC Name: ((((Z)-2-((2R,3R,4R,5R)-3-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-4-methyltetrahydrofuran-2-yl)vinyl)phosphoryl)bis(oxy))bis(methylene) bis(2,2-dimethylpropanoate)

InChI: InChI=1S/C32H51FN4O12P2/c1-21(2)37(22(3)4)50(45-17-12-15-34)49-25-23(48-26(32(25,11)33)36-16-13-24(38)35-29(36)41)14-18-51(42,46-19-43-27(39)30(5,6)7)47-20-44-28(40)31(8,9)10/h13-14,16,18,21-23,25-26H,12,17,19-20H2,1-11H3,(H,35,38,41)/b18-14-/t23-,25-,26-,32-,50?/m1/s1

Synonyms: 5'-(Z)-VP-2'-deoxy-2'-F-2'-Me-U-CE-Phoshoramidite; 5'-POM-(Z)-vinyl phosphonate-2'-deoxy-2'-fluoro-2'-methyl-U-3'-CE-Phosphoramidite; 5'-(Z)-VP-2'-F-2'-Me-U Phosphoramidite

Related CAS: 2923479-96-1 (E-isomer)

5'-(E)-VP-2'-F-C(Bz)-CE-Phoshoramidite

Description: 5'-(E)-VP-2'-F-C(Bz)-CE-Phosphoramidite is a modified phosphoramidite featuring a 5'-(E)-vinyl group, a 2'-fluoro modification, and a benzoyl (Bz) protecting group on the cytosine base. This compound is utilized in solid-phase oligonucleotide synthesis, where it enhances stability and facilitates the incorporation of modified nucleotides into RNA or DNA sequences for research and therapeutic applications. Its unique structural features contribute to improved biochemical properties, making it valuable in the development of nucleic acid-based technologies.

CAT: BRP-02371

MF: C38H54FN5O12P2

MF: 853.82

Purity: ≥95%

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InChIKey: SEELSGXIZIBYES-JDXGGGBYSA-N

CanonicalSMILES: F[C@@H]1[C@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](/C=C/P(OCOC(C(C)(C)C)=O)(OCOC(C(C)(C)C)=O)=O)O[C@H]1N2C(N=C(NC(C3=CC=CC=C3)=O)C=C2)=O

IUPAC Name: ((((E)-2-((2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-3-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-4-fluorotetrahydrofuran-2-yl)vinyl)phosphoryl)bis(oxy))bis(methylene) bis(2,2-dimethylpropanoate)

InChI: InChI=1S/C38H54FN5O12P2/c1-25(2)44(26(3)4)57(52-21-14-19-40)56-31-28(18-22-58(49,53-23-50-34(46)37(5,6)7)54-24-51-35(47)38(8,9)10)55-33(30(31)39)43-20-17-29(42-36(43)48)41-32(45)27-15-12-11-13-16-27/h11-13,15-18,20,22,25-26,28,30-31,33H,14,21,23-24H2,1-10H3,(H,41,42,45,48)/b22-18+/t28-,30-,31-,33-,57?/m1/s1

Synonyms: 5'-POM-(E)-vinyl phosphonate-2'-O-fluoro-rC(Bz)-3'-CE-Phosphoramidite; 5'(E)-VP-2’-F-C(Bz)-CE-Phoshoramidite

3'-O-DMTr-2'-F-A(Bz)-CE-Reverse-Phosphoramidite

Description: 3'-O-DMTr-2'-F-A(Bz)-CE-Reverse-Phosphoramidite is a modified phosphoramidite that includes a 3'-dimethoxytrityl (DMTr) protecting group, a 2'-fluoro modification, and a benzoyl (Bz) protecting group on the adenine base. This compound is employed in the synthesis of oligonucleotides, providing enhanced stability and control during the incorporation of modified nucleotides. Its structural characteristics contribute to improved performance in various applications, including gene therapy and RNA interference, where precise nucleotide incorporation is essential for effective function.

CAT: BRP-02372

CAS: 2227293-35-6

MF: C47H51FN7O7P

MF: 875.92

Purity: ≥95%

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InChIKey: NZDMBUCNULHYQM-MSIRFHFKSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)F)OC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC

IUPAC Name: N-[9-[(2R,3R,4R,5R)-4-[bis(4-methoxyphenyl)-phenylmethoxy]-5-[[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxymethyl]-3-fluorooxolan-2-yl]purin-6-yl]benzamide

InChI: InChI=1S/C47H51FN7O7P/c1-31(2)55(32(3)4)63(59-27-13-26-49)60-28-39-42(40(48)46(61-39)54-30-52-41-43(50-29-51-44(41)54)53-45(56)33-14-9-7-10-15-33)62-47(34-16-11-8-12-17-34,35-18-22-37(57-5)23-19-35)36-20-24-38(58-6)25-21-36/h7-12,14-25,29-32,39-40,42,46H,13,27-28H2,1-6H3,(H,50,51,53,56)/t39-,40-,42-,46-,63?/m1/s1

Synonyms: ((2R,3R,4R,5R)-5-(6-Benzamido-9H-purin-9-yl)-3-(bis(4-methoxyphenyl)(phenyl)methoxy)-4-fluorotetrahydrofuran-2-yl)methyl (2-cyanoethyl) diisopropylphosphoramidite; 2'-Fluoro-3'-DMT-Adenosine (n-bz) 5'-CED phosphoramidite; 3'-O-DMTr-2'-F-A(Bz)-5'-CE-Phosphoramidite; 3'-DMT-2'-F-A(Bz)-CE Reverse

3'-O-DMTr-2'-F-C(Bz)-CE-Reverse-Phosphoramidite

Description: 3'-O-DMTr-2'-F-C(Bz)-CE-Reverse-Phosphoramidite is a specialized phosphoramidite featuring a 3'-dimethoxytrityl (DMTr) protecting group, a 2'-fluoro modification, and a benzoyl (Bz) protecting group on the cytosine base. This compound is utilized in the synthesis of oligonucleotides, offering enhanced stability and efficiency in the incorporation of modified nucleotides. Its unique structural features make it particularly useful in applications such as RNA therapeutics and antisense oligonucleotide development, where precise nucleotide sequence control is critical for desired biological activity.

CAT: BRP-02373

CAS: 3025999-66-7

MF: C46H51FN5O8P

MF: 851.90

Purity: ≥95%

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InChIKey: XLXVPPWWZBIAAK-GNUWXFRUSA-N

CanonicalSMILES: N#CCCOP(OCC1OC(N2C=CC(=NC2=O)NC(=O)C=3C=CC=CC3)C(F)C1OC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C

IUPAC Name: ((2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-3-(bis(4-methoxyphenyl)(phenyl)methoxy)-4-fluorotetrahydrofuran-2-yl)methyl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C46H51FN5O8P/c1-31(2)52(32(3)4)61(57-29-13-27-48)58-30-39-42(41(47)44(59-39)51-28-26-40(50-45(51)54)49-43(53)33-14-9-7-10-15-33)60-46(34-16-11-8-12-17-34,35-18-22-37(55-5)23-19-35)36-20-24-38(56-6)25-21-36/h7-12,14-26,28,31-32,39,41-42,44H,13,29-30H2,1-6H3,(H,49,50,53,54)/t39-,41-,42-,44-,61?/m1/s1

Synonyms: 2'-Fluoro-3'-DMT-Cytidine (n-bz) 5'-CED phosphoramidite; 3'-O-DMTr-2'-F-C(Bz)-5'-CE-Phosphoramidite; 3'-DMT-2'-F-C(Bz)-CE Reverse

SNA MeC(Bz) amidite

Description: SNA MeC(Bz) amidite is a modified phosphoramidite that features a methylcytosine base with a benzoyl (Bz) protecting group, designed for use in the synthesis of SNA. This compound allows for the incorporation of methylated cytosine into oligonucleotides, enhancing their stability and potential for gene regulation applications. The unique structural characteristics of SNA MeC(Bz) amidite support advancements in therapeutic strategies, particularly in areas involving epigenetics and RNA interference, where the modulation of gene expression is crucial.

CAT: BRP-02374

MF: C47H55N6O8P

MF: 862.97

Purity: ≥95%

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InChIKey: INDCRCPSOKWLRY-WSVBJYSDSA-N

CanonicalSMILES: O=C(CN1C=C(C(NC(C2=CC=CC=C2)=O)=NC1=O)C)N[C@@H](COC(C(C=C3)=CC=C3OC)(C(C=C4)=CC=C4OC)C5=CC=CC=C5)COP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: (S)-2-(2-(4-benzamido-5-methyl-2-oxopyrimidin-1(2H)-yl)acetamido)-3-(bis(4-methoxyphenyl)(phenyl)methoxy)propyl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C47H55N6O8P/c1-33(2)53(34(3)4)62(60-28-14-27-48)61-32-40(49-43(54)30-52-29-35(5)44(51-46(52)56)50-45(55)36-15-10-8-11-16-36)31-59-47(37-17-12-9-13-18-37,38-19-23-41(57-6)24-20-38)39-21-25-42(58-7)26-22-39/h8-13,15-26,29,33-34,40H,14,28,30-32H2,1-7H3,(H,49,54)(H,50,51,55,56)/t40-,62?/m0/s1

Synonyms: SNA-C(Bz)-5-Me-CE-Phosphoramidite; SNA 5-Me-C(Bz) amidite; PNA-C(Bz)-5-Me-CE-Phosphoramidite

SNA U amidite

Description: SNA U amidite is a modified phosphoramidite that features a uracil base, specifically designed for the synthesis of SNA. This compound facilitates the incorporation of uracil into oligonucleotides, enhancing their stability and hybridization properties compared to traditional nucleic acids. Its unique structural attributes make SNA U amidite valuable for various applications in molecular biology and therapeutic development, particularly in the context of RNA interference and gene regulation, where precise control over nucleic acid sequences is essential for effective function.

CAT: BRP-02375

MF: C39H48N5O8P

MF: 745.81

Purity: ≥95%

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InChIKey: ZZADINXNUNWRGE-IAQARZHUSA-N

CanonicalSMILES: O=C(CN1C=CC(NC1=O)=O)N[C@@H](COC(C(C=C2)=CC=C2OC)(C(C=C3)=CC=C3OC)C4=CC=CC=C4)COP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: (S)-3-(bis(4-methoxyphenyl)(phenyl)methoxy)-2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamido)propyl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C39H48N5O8P/c1-28(2)44(29(3)4)53(51-24-10-22-40)52-27-33(41-37(46)25-43-23-21-36(45)42-38(43)47)26-50-39(30-11-8-7-9-12-30,31-13-17-34(48-5)18-14-31)32-15-19-35(49-6)20-16-32/h7-9,11-21,23,28-29,33H,10,24-27H2,1-6H3,(H,41,46)(H,42,45,47)/t33-,53?/m0/s1

Synonyms: SNA-U-CE-Phosphoramidite; PNA-U-CE-Phosphoramidite

HNA-A(Bz)-CE-Phosphoramidite

Description: HNA-A(Bz)-CE-Phosphoramidite is a modified phosphoramidite that features an adenine base protected by a benzoyl (Bz) group, specifically designed for the synthesis of hexitol nucleic acids (HNA). This compound facilitates the incorporation of adenine into oligonucleotides, enhancing their stability and hybridization properties compared to traditional nucleic acids. Its unique structural characteristics make HNA-A(Bz)-CE-Phosphoramidite valuable for a variety of applications in molecular biology and therapeutic development, particularly in gene regulation and nucleic acid-based therapies, where precise control over sequence and functionality is essential for achieving desired biological effects.

CAT: BRP-02376

MF: C48H54N7O7P

MF: 871.98

Purity: ≥95%

Appearance: Colorless to light yellow crystalline or white, off-white to light yellow amorphous dry powder

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InChIKey: XGEWWLZZXZMDQZ-RCZAHRGASA-N

CanonicalSMILES: N#CCCOP(N(C(C)C)C(C)C)O[C@@H]1[C@@H](COC(C2=CC=CC=C2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)OC[C@@H](N5C=NC6=C5N=CN=C6NC(C7=CC=CC=C7)=O)C1

IUPAC Name: (2R,3S,5S)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)tetrahydro-2H-pyran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C48H54N7O7P/c1-33(2)55(34(3)4)63(61-27-13-26-49)62-42-28-39(54-32-52-44-45(50-31-51-46(44)54)53-47(56)35-14-9-7-10-15-35)29-59-43(42)30-60-48(36-16-11-8-12-17-36,37-18-22-40(57-5)23-19-37)38-20-24-41(58-6)25-21-38/h7-12,14-25,31-34,39,42-43H,13,27-30H2,1-6H3,(H,50,51,53,56)/t39-,42-,43+,63?/m0/s1

Synonyms: HNA-A(Bz) Phosphoramidite; 1,5-Anhydro-2,3-dideoxy-6-O-(4,4'-dimethoxytrityl)-2-(N6-benzoyladenosin-1-yl)-D-arabino-hexitol-4-[(2-cyanoethyl)-(N,N-diisopropyl)]-Phosphoramidite

HNA-G(iBu)-CE-Phosphoramidite

Description: HNA-G(iBu)-CE-Phosphoramidite is a modified phosphoramidite featuring a guanine base with an isobutyl (iBu) protecting group, specifically designed for the synthesis of hexitol nucleic acids (HNA). This compound allows for the incorporation of guanine into oligonucleotides, enhancing their stability and hybridization capabilities compared to conventional nucleic acids. Its unique structure supports applications in molecular biology and therapeutic development, particularly in gene regulation and nucleic acid-based therapies, where precise sequence control and improved functional properties are critical for effective biological interactions.

CAT: BRP-02377

MF: C45H56N7O8P

MF: 853.96

Purity: ≥95%

Appearance: Colorless to light yellow crystalline or white, off-white to light yellow amorphous dry powder

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InChIKey: TTZYXYZKHYKGNZ-WKOKJNIDSA-N

CanonicalSMILES: N#CCCOP(N(C(C)C)C(C)C)O[C@@H]1[C@@H](COC(C2=CC=CC=C2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)OC[C@@H](N5C=NC6=C5N=C(NC(C(C)C)=O)NC6=O)C1

IUPAC Name: (2R,3S,5S)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydro-2H-pyran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C45H56N7O8P/c1-29(2)42(53)49-44-48-41-40(43(54)50-44)47-28-51(41)35-25-38(60-61(59-24-12-23-46)52(30(3)4)31(5)6)39(57-26-35)27-58-45(32-13-10-9-11-14-32,33-15-19-36(55-7)20-16-33)34-17-21-37(56-8)22-18-34/h9-11,13-22,28-31,35,38-39H,12,24-27H2,1-8H3,(H2,48,49,50,53,54)/t35-,38-,39+,61?/m0/s1

Synonyms: HNA-G(iBu) Phosphoramidite; 1,5-Anhydro-2,3-dideoxy-6-O-(4,4'-dimethoxytrityl)-2-(N4-isobutyrylguanosin-1-yl)-D-arabino-hexitol-4-[(2-cyanoethyl)-(N,N-diisopropyl)]-Phosphoramidite

HNA-C(Bz)-CE-Phosphoramidite

Description: HNA-C(Bz)-CE-Phosphoramidite is a modified phosphoramidite featuring a cytosine base protected by a benzoyl (Bz) group, specifically designed for the synthesis of hexitol nucleic acids (HNA). This compound facilitates the incorporation of cytosine into oligonucleotides, providing enhanced stability and hybridization properties compared to traditional nucleic acids. Its unique structural characteristics make HNA-C(Bz)-CE-Phosphoramidite valuable for various applications in molecular biology and therapeutic development, particularly in areas such as gene regulation and nucleic acid-based therapies, where precise sequence control is essential for desired biological outcomes.

CAT: BRP-02378

MF: C47H54N5O8P

MF: 847.95

Purity: ≥95%

Appearance: Colorless to light yellow crystalline or white, off-white to light yellow amorphous dry powder

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Storage: Store at -20 °C

InChIKey: SEINFBLWWSBNOE-GRKJCQINSA-N

CanonicalSMILES: O=C1N=C(NC(C2=CC=CC=C2)=O)C=CN1[C@H]3C[C@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](COC(C4=CC=CC=C4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)OC3

IUPAC Name: (2R,3S,5S)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)tetrahydro-2H-pyran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C47H54N5O8P/c1-33(2)52(34(3)4)61(59-29-13-27-48)60-42-30-39(51-28-26-44(50-46(51)54)49-45(53)35-14-9-7-10-15-35)31-57-43(42)32-58-47(36-16-11-8-12-17-36,37-18-22-40(55-5)23-19-37)38-20-24-41(56-6)25-21-38/h7-12,14-26,28,33-34,39,42-43H,13,29-32H2,1-6H3,(H,49,50,53,54)/t39-,42-,43+,61?/m0/s1

Synonyms: HNA-C(Bz) Phosphoramidite; 1,5-Anhydro-2,3-dideoxy-6-O-(4,4'-dimethoxytrityl)-2-(N4-benzoylcytosin-1-yl)-D-arabino-hexitol-4-[(2-cyanoethyl)-(N,N-diisopropyl)]-Phosphoramidite

HNA-U-CE-Phosphoramidite

Description: HNA-U-CE-Phosphoramidite is a modified phosphoramidite featuring a uracil base designed for the synthesis of hexitol nucleic acids (HNA). This compound enables the incorporation of uracil into oligonucleotides, enhancing their stability and hybridization capabilities compared to conventional nucleic acids. Its unique structure is particularly useful in applications related to gene regulation, antisense technology, and therapeutic development, where the enhanced properties of HNA can be leveraged for improved specificity and efficacy in molecular interactions.

CAT: BRP-02379

MF: C40H49N4O8P

MF: 744.83

Purity: ≥95%

Appearance: Colorless to light yellow crystalline or white, off-white to light yellow amorphous dry powder

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Storage: Store at -20 °C

InChIKey: WPRYWMKQXWBASG-RLSYHYOISA-N

CanonicalSMILES: O=C(NC1=O)C=CN1[C@H]2C[C@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](COC(C3=CC=CC=C3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)OC2

IUPAC Name: (2R,3S,5S)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydro-2H-pyran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C40H49N4O8P/c1-28(2)44(29(3)4)53(51-24-10-22-41)52-36-25-33(43-23-21-38(45)42-39(43)46)26-49-37(36)27-50-40(30-11-8-7-9-12-30,31-13-17-34(47-5)18-14-31)32-15-19-35(48-6)20-16-32/h7-9,11-21,23,28-29,33,36-37H,10,24-27H2,1-6H3,(H,42,45,46)/t33-,36-,37+,53?/m0/s1

Synonyms: HNA-U Phosphoramidite; 1,5-Anhydro-2,3-dideoxy-6-O-(4,4'-dimethoxytrityl)-2-(uridin-1-yl)-D-arabino-hexitol-4-[(2-cyanoethyl)-(N,N-diisopropropyl)]-Phosphoramidite