Phosphoramidites

Description: GalNAc-NAG-25 Phosphoramidite is a modified phosphoramidite that incorporates a N-acetylgalactosamine (GalNAc) moiety linked to the NAG component, specifically designed for the synthesis of oligonucleotides. This compound enhances the stability and bioactivity of nucleic acids, particularly in applications involving targeted delivery and therapeutic interventions. Its unique structural features allow for improved interactions with cellular receptors, making GalNAc-NAG-25 Phosphoramidite valuable in the development of glyco-engineered therapeutics and in the field of glycobiology, where carbohydrate-based modifications play a crucial role in biological processes.

CAT: BRP-02368

CAS: 2130036-52-9

Molecular Formula: C88H145N10O43P

Molecular Weight: 2062.13

Purity: ≥95%

Appearance: White to light yellow powder

Description: 5'-(E)-VP-2'-F-U-Phosphoramidite is a chemical reagent used in the synthesis of oligonucleotides. It features a 5' end with a trans configuration, incorporating 2'-fluorouridine (2'-F-U) and a CE group, which enhances synthesis efficiency and stability. This compound is widely utilized in nucleic acid chemistry and biotechnology, particularly in gene engineering and drug development.

CAT: BRP-02369

Molecular Formula: C31H49FN4O12P2

Molecular Weight: 750.69

Purity: ≥95%

Description: 5'-(Z)-VP-2'-F-2'-Me-U-Phosphoramidite is a specialized chemical reagent designed for the synthesis of oligonucleotides. This compound features a 5' end with a cis configuration, incorporating 2'-fluoro-2'-methyluridine (2'-F-2'-Me-U) along with a CE group. The modifications enhance the stability and efficiency of the synthesis process, making it particularly valuable in nucleic acid research, gene therapy, and drug development. Its unique structural properties allow for improved interactions and functionality in various biotechnological applications.

CAT: BRP-02370

CAS: 2923487-59-4

Molecular Formula: C32H51FN4O12P2

Molecular Weight: 764.71

Purity: ≥95%

Description: 5'-(E)-VP-2'-F-C(Bz)-CE-Phosphoramidite is a modified phosphoramidite featuring a 5'-(E)-vinyl group, a 2'-fluoro modification, and a benzoyl (Bz) protecting group on the cytosine base. This compound is utilized in solid-phase oligonucleotide synthesis, where it enhances stability and facilitates the incorporation of modified nucleotides into RNA or DNA sequences for research and therapeutic applications. Its unique structural features contribute to improved biochemical properties, making it valuable in the development of nucleic acid-based technologies.

CAT: BRP-02371

Molecular Formula: C38H54FN5O12P2

Molecular Weight: 853.82

Purity: ≥95%

Description: 3'-O-DMTr-2'-F-A(Bz)-CE-Reverse-Phosphoramidite is a modified phosphoramidite that includes a 3'-dimethoxytrityl (DMTr) protecting group, a 2'-fluoro modification, and a benzoyl (Bz) protecting group on the adenine base. This compound is employed in the synthesis of oligonucleotides, providing enhanced stability and control during the incorporation of modified nucleotides. Its structural characteristics contribute to improved performance in various applications, including gene therapy and RNA interference, where precise nucleotide incorporation is essential for effective function.

CAT: BRP-02372

CAS: 2227293-35-6

Molecular Formula: C47H51FN7O7P

Molecular Weight: 875.92

Purity: ≥95%

Description: 3'-O-DMTr-2'-F-C(Bz)-CE-Reverse-Phosphoramidite is a specialized phosphoramidite featuring a 3'-dimethoxytrityl (DMTr) protecting group, a 2'-fluoro modification, and a benzoyl (Bz) protecting group on the cytosine base. This compound is utilized in the synthesis of oligonucleotides, offering enhanced stability and efficiency in the incorporation of modified nucleotides. Its unique structural features make it particularly useful in applications such as RNA therapeutics and antisense oligonucleotide development, where precise nucleotide sequence control is critical for desired biological activity.

CAT: BRP-02373

CAS: 3025999-66-7

Molecular Formula: C46H51FN5O8P

Molecular Weight: 851.90

Purity: ≥95%

Description: SNA MeC(Bz) amidite is a modified phosphoramidite that features a methylcytosine base with a benzoyl (Bz) protecting group, designed for use in the synthesis of SNA. This compound allows for the incorporation of methylated cytosine into oligonucleotides, enhancing their stability and potential for gene regulation applications. The unique structural characteristics of SNA MeC(Bz) amidite support advancements in therapeutic strategies, particularly in areas involving epigenetics and RNA interference, where the modulation of gene expression is crucial.

CAT: BRP-02374

Molecular Formula: C47H55N6O8P

Molecular Weight: 862.97

Purity: ≥95%

Description: SNA U amidite is a modified phosphoramidite that features a uracil base, specifically designed for the synthesis of SNA. This compound facilitates the incorporation of uracil into oligonucleotides, enhancing their stability and hybridization properties compared to traditional nucleic acids. Its unique structural attributes make SNA U amidite valuable for various applications in molecular biology and therapeutic development, particularly in the context of RNA interference and gene regulation, where precise control over nucleic acid sequences is essential for effective function.

CAT: BRP-02375

Molecular Formula: C39H48N5O8P

Molecular Weight: 745.81

Purity: ≥95%

Description: HNA-A(Bz)-CE-Phosphoramidite is a modified phosphoramidite that features an adenine base protected by a benzoyl (Bz) group, specifically designed for the synthesis of hexitol nucleic acids (HNA). This compound facilitates the incorporation of adenine into oligonucleotides, enhancing their stability and hybridization properties compared to traditional nucleic acids. Its unique structural characteristics make HNA-A(Bz)-CE-Phosphoramidite valuable for a variety of applications in molecular biology and therapeutic development, particularly in gene regulation and nucleic acid-based therapies, where precise control over sequence and functionality is essential for achieving desired biological effects.

CAT: BRP-02376

Molecular Formula: C48H54N7O7P

Molecular Weight: 871.98

Purity: ≥95%

Appearance: Colorless to light yellow crystalline or white, off-white to light yellow amorphous dry powder

Description: HNA-G(iBu)-CE-Phosphoramidite is a modified phosphoramidite featuring a guanine base with an isobutyl (iBu) protecting group, specifically designed for the synthesis of hexitol nucleic acids (HNA). This compound allows for the incorporation of guanine into oligonucleotides, enhancing their stability and hybridization capabilities compared to conventional nucleic acids. Its unique structure supports applications in molecular biology and therapeutic development, particularly in gene regulation and nucleic acid-based therapies, where precise sequence control and improved functional properties are critical for effective biological interactions.

CAT: BRP-02377

Molecular Formula: C45H56N7O8P

Molecular Weight: 853.96

Purity: ≥95%

Appearance: Colorless to light yellow crystalline or white, off-white to light yellow amorphous dry powder

Description: HNA-C(Bz)-CE-Phosphoramidite is a modified phosphoramidite featuring a cytosine base protected by a benzoyl (Bz) group, specifically designed for the synthesis of hexitol nucleic acids (HNA). This compound facilitates the incorporation of cytosine into oligonucleotides, providing enhanced stability and hybridization properties compared to traditional nucleic acids. Its unique structural characteristics make HNA-C(Bz)-CE-Phosphoramidite valuable for various applications in molecular biology and therapeutic development, particularly in areas such as gene regulation and nucleic acid-based therapies, where precise sequence control is essential for desired biological outcomes.

CAT: BRP-02378

Molecular Formula: C47H54N5O8P

Molecular Weight: 847.95

Purity: ≥95%

Appearance: Colorless to light yellow crystalline or white, off-white to light yellow amorphous dry powder

Description: HNA-U-CE-Phosphoramidite is a modified phosphoramidite featuring a uracil base designed for the synthesis of hexitol nucleic acids (HNA). This compound enables the incorporation of uracil into oligonucleotides, enhancing their stability and hybridization capabilities compared to conventional nucleic acids. Its unique structure is particularly useful in applications related to gene regulation, antisense technology, and therapeutic development, where the enhanced properties of HNA can be leveraged for improved specificity and efficacy in molecular interactions.

CAT: BRP-02379

Molecular Formula: C40H49N4O8P

Molecular Weight: 744.83

Purity: ≥95%

Appearance: Colorless to light yellow crystalline or white, off-white to light yellow amorphous dry powder

Description: 5'-VP-2'-OMe-U-CE-Phosphoramidite is a sophisticated biochemical utilized in the pharmaceutical industry. This molecule plays a vital role in the synthesis of antiviral medications targeted at treating diseases like Hepatitis C.

CAT: BRP-02384

CAS: 1882067-09-5

Molecular Formula: C32H52N4O13P2

Molecular Weight: 762.72

Purity: ≥98%

Description: 5'-VP-2'-0Me-A(Bz)-CE-Phosphoramidite is used in oligonucleotide synthesis. It is employed to introduce modified adenine residues with altered chemical properties into nucleic acid sequences, suitable for applications such as RNA interference (RNAi), gene silencing, and nucleic acid therapeutics.

CAT: BRP-02385

Molecular Formula: C40H57N7O12P2

Molecular Weight: 889.88

Purity: ≥98%

Description: 5'-VP-2'-OMe-C(Bz)-CE-Phosphoramidite is employed to introduce modified cytosine residues with altered chemical properties into nucleic acid sequences, suitable for applications such as RNA interference (RNAi), gene silencing, and nucleic acid therapeutics.

CAT: BRP-02386

Molecular Formula: C39H57N5O13P2

Molecular Weight: 865.85

Purity: ≥98%

Description: 2'-OMe-C(iPr-Pac) Phosphoramidite is a modified phosphoramidite featuring a 2'-O-methyl group on the ribose sugar and an isopropylphenoxyacetyl (iPr-Pac) protecting group on the cytosine base's exocyclic amine. The sugar moiety is equipped with a 3'-cyanoethyl (CE) phosphoramidite group, enabling its incorporation into oligonucleotides during automated synthesis. The 2'-O-methyl modification enhances the stability and nuclease resistance of the resulting RNA or DNA strands, making it a key component in the development of antisense oligonucleotides, siRNA, and other therapeutic nucleic acids. It is widely used in research and therapeutic applications to improve the pharmacokinetic properties of nucleic acid-based molecules.

CAT: BRP-02387

Molecular Formula: C51H62N5O10P

Molecular Weight: 936.06

Purity: ≥97%

Description: 2,6-Diamino(N2-ibu,N6-dmf)-DMT-2'-O-MOE-purine-riboside-CE Phosphoramidite is a modified phosphoramidite designed for oligonucleotide synthesis. It features a 2,6-diaminopurine base with an N2-isobutyryl (ibu) group and an N6-dimethylformamidine (dmf) protecting group, enhancing its chemical stability during synthesis. The ribose sugar is modified with a 2'-O-methoxyethyl (MOE) group, improving the nuclease resistance and hybridization properties of the resulting oligonucleotides. The 5'-hydroxyl group is protected by a dimethoxytrityl (DMT) group, and the 3'-cyanoethyl (CE) phosphoramidite enables efficient incorporation into oligonucleotides. This compound is widely used in therapeutic oligonucleotide development, including antisense and siRNA applications, where enhanced stability and binding affinity are critical.

CAT: BRP-02388

Molecular Formula: C50H66N9O9P

Molecular Weight: 968.11

Purity: ≥95%

Description: 2,6-Diamino(N2,N6-di-Propionyl)-DMT-2'-O-MOE-purine-riboside-CE Phosphoramidite is a chemically modified phosphoramidite used in oligonucleotide synthesis. It features a 2,6-diaminopurine base with both the N2 and N6 positions protected by propionyl groups, enhancing its stability during chemical synthesis. The ribose sugar is functionalized with a 2'-O-methoxyethyl (MOE) group, which improves the nuclease resistance and hybridization properties of the synthesized oligonucleotides. The 5'-hydroxyl group is protected by a dimethoxytrityl (DMT) group, and the 3'-cyanoethyl (CE) phosphoramidite allows efficient incorporation into oligonucleotide strands. This compound is especially valuable in the development of antisense oligonucleotides and RNA therapeutics, providing enhanced stability and binding affinity for biological applications.

CAT: BRP-02389

Molecular Formula: C49H63N8O10P

Molecular Weight: 955.06

Purity: ≥98%

Description: 2'-O-MOE-N6-Me-rA Phosphoramidite is a modified phosphoramidite featuring a 2'-O-methoxyethyl (MOE) group on the ribose sugar and a methyl group on the N6 position of the adenine base. These modifications enhance the stability, nuclease resistance, and binding affinity of the resulting oligonucleotides. The 3'-cyanoethyl (CE) phosphoramidite group enables efficient incorporation into oligonucleotides during automated synthesis. This compound is commonly used in the development of antisense oligonucleotides, siRNA, and other therapeutic nucleic acids, providing improved pharmacokinetic properties and enhanced biological performance in research and therapeutic applications.

CAT: BRP-02390

Molecular Formula: C44H56N7O8P

Molecular Weight: 841.95

Purity: ≥98%

Description: 4-Thio-2'-OMe-rU Phosphoramidite is a modified phosphoramidite where the oxygen atom at the 4-position of the uracil base is replaced with a sulfur atom, and the ribose sugar is functionalized with a 2'-O-methyl (OMe) group. The 3'-cyanoethyl (CE) phosphoramidite group allows its incorporation into oligonucleotides via automated synthesis. This modification enhances the stability of RNA analogs and provides unique chemical properties, such as increased resistance to nuclease degradation and the ability to engage in thiol-specific reactions. It is particularly valuable in therapeutic oligonucleotide development, RNA structure-function studies, and the creation of oligonucleotides with enhanced biological activity.

CAT: BRP-02391

CAS: 1338923-37-7

Molecular Formula: C43H52N5O8PS

Molecular Weight: 829.95

Purity: ≥95%