RNA therapies are a successful new approach in medicine, providing unprecedented precision in the treatment of a wide range of diseases. RNA-based therapies, including small interfering RNAs (siRNAs) and messenger RNAs (mRNAs), have emerged as new ways to treat or prevent disease. As a pioneer in pharmaceutical services, BOC Sciences demonstrated the industry's most cutting-edge RNA drug delivery systems that can facilitate the rapid development of life-saving RNA therapies.
A drug delivery system is an agent or device that is a natural way to introduce a therapeutic substance, such as a therapeutic drug or imaging agent, into the body. In RNA therapeutics, drug delivery systems are critical for protecting RNA drug molecules and directing them safely into target cells. These systems must protect the RNA from degradation, facilitate cellular uptake, and release the therapeutic load at its site or range of action. The delivery of RNA-based therapies is highly dependent on the complexity and functionality of the system selected.
Naked RNA drugs will degrade rapidly as there are a large number of RNases in the blood, it will affect the drug efficacy of RNAi. Therefore, it's very important to improve the stability of naked RNA. Except for chemically modification, researchers are working hard on siRNA drug delivery system nowadays. Drug delivery system is becoming an important tool for delivering the candidate siRNA drugs to target cells. In August 2018, the US FDA approved the first siRNA drug, called ONPATTRO™ (Patisiran) by Alnylam Pharmaceuticals, for the treatment of hereditary transthyretin polyneuropathy. This was an important milestone for the field of siRNA drugs and opens the door for the research of other siRNA drug delivery system.
BOC Sciences has developed a suite of advanced drug delivery systems tailored specifically for RNA therapeutics. Our systems are designed to address the unique challenges associated with RNA delivery, including stability, targeting, and efficient cellular uptake. Here, we discuss some of the key delivery systems offered by BOC Sciences.
Drug Delivery System | Description | Get a Qoute |
Lipid Nanoparticle | BOC Sciences specializes in providing you with fully validated LNP delivery systems for nucleic acids, especially siRNA and mRNA, to induce functional protein expression and to study the potential of mRNA and LNP-based gene therapy. | Inquiry |
Liposomes | BOC Sciences is dedicated to assisting you in exploring the complexity of liposomes, nucleic acid delivery mechanisms, and applications through our cutting-edge liposome delivery services. | Inquiry |
Exosome | BOC Sciences is dedicated to further investigating and developing innovative exosomes delivery systems, which have been successfully applied to deliver various drugs, particularly nucleic acid (DNA/RNA) therapeutics. | Inquiry |
Cationic Nanoemulsions | BOC Sciences offers cationic nanoemulsion-based mRNA delivery systems, promising a one-stop service from mRNA synthesis to cationic nanoemulsion encapsulation to efficiently assist our customers in vaccine development and production. | Inquiry |
Cationic Polypeptides | BOC Sciences offers fully validated cationic peptide mRNA delivery systems to assist customers in further research into the efficacy, safety and long-term stability of mRNA vaccines. | Inquiry |
Polymer Complexes | BOC Sciences provides fully validated and optimised polymer complex mRNA delivery systems to assist customers in the development and production of mRNA vaccines for infectious disease and cancer control applications. | Inquiry |
Dynamic Polyconjugates (DPC) | BOC Sciences is committed to providing siRNA drug design and in vivo delivery solutions for drug development, solving our clients' research challenges. | Inquiry |
Cholesterol-siRNA Conjugates | BOC Sciences provides cholesterol-siRNA conjugates with high quality. We can design and synthesis the siRNA based on the target gene, and we also have the capacity to produce high quality cholesterol. | Inquiry |
Antibody-siRNA Conjugates | BOC Sciences are inspired and have already developed the antibody-based delivery technology by conjugating antibody for siRNA delivery. | Inquiry |
Nanoparticle-siRNA Conjugates | BOC Sciences understands the significance of nanoparticle-siRNA conjugates in the development of RNA therapy and commit to supplying clients across the globe with an earnest service. | Inquiry |
Peptide-siRNA conjugates | BOC Sciences offers high quality siRNA couplings for various types of peptides, such as CPPs, since we can provide targeted gene-based design and synthesis of siRNA. | Inquiry |
Polymer-siRNA Conjugates | BOC Sciences can provide custom multimeric polymer-siRNAs of varying purity and scale depending on the intended application. | Inquiry |
GalNAc-siRNA Conjugates | BOC Sciences promises to offer you with GalNAc-siRNA conjugation services to help you conduct further research on GalNAc-siRNA conjugates and explore their mores omnics capabilities. | Inquiry |
Aptamer-siRNA conjugates | Utilizing the promise of aptamer-siRNA conjugates, BOC Sciences is committed to help customers worldwide to achieve significant progress in development of targeted gene silencing therapies. | Inquiry |
Folic acid–siRNA conjugates | BOC Sciences has expert technical support to provide accurate and affordable folic acid–siRNA conjugates services. | Inquiry |
CpG-siRNA Conjugates | BOC Sciences is committed to providing quality services related to CpG-siRNA conjugates with a flexible synthetic analysis service. | Inquiry |
For more drug delivery systems, please contact us directly for customized services.
Custom siRNA Synthesis | Custom mRNA Synthesis | Custom miRNA Mimics Synthesis |
GMP Oligonucleotide Manufacturing Services |
Nanoparticle Carrier-Another Option for Nucleic Acid Delivery
Reviews of siRNA Nanocarriers for Blood-Brain Barrier(BBB) Penetration
DNA Origami for Nanomanufacturing, Biosensing and Drug Delivery
mRNA Vaccine Delivery Strategy
GalNAc Technology for Oligonucleotide Drug Delivery
BOC Sciences stands out as a premier provider of RNA drug delivery systems because of the following widely acclaimed advantages.
With over 20 years of hands-on experience in the pharmaceutical industry, BOC Sciences has the expertise and capabilities to support your peptide therapeutic development program. We do this by researching and developing a novel class of drugs with revolutionary RNA therapeutic potential.
We recognize that each RNA therapeutic requires a unique delivery mechanism, and BOC Sciences can provide a variety of delivery options based on your needs. From fine-tuning the formulation of specific RNA molecules to creating novel delivery platforms, we offer a variety of options to ensure success.
From formulation development to large-scale manufacturing, BOC Sciences provides end-to-end support for RNA drug delivery, offering a team of professionals to help clients prepare nucleotide drugs. Proprietary capabilities include analytical characterization, stability testing and regulatory support to facilitate the transition from discovery to preclinical use.
Our RNA delivery systems have been validated in numerous preclinical studies, demonstrating their efficacy and safety. BOC Sciences' commitment to quality and performance is reflected in the success of our delivery platforms in various therapeutic areas.
BOC Sciences utilizes its state-of-the-art facilities with the latest technology in RNA delivery system creation and production. What sets us apart is our state-of-the-art infrastructure that allows us to provide superior solutions, products and services on a global scale.
Effective delivery of rna therapeutics is critical to realize their full therapeutic potential. In the synthesis of RNA therapeutics, BOC Sciences leads its business by providing many suitable delivery platforms for various types of them (e.g., small interfering RNA) to deal with potential additional conditions. From lipid nanoparticles to exosome-based systems, our innovative approach ensures efficient and effective delivery of RNA molecules. With a wealth of knowledge, customizable solutions and a history of successful cases, BOC Science is the partner to drive your RNA therapy from the lab to the preclinical.
GMP Oligonucleotide Manufacturing Service
For more than 15 years, BOC Sciences has been manufacturing oligonucleotides for pre-clinical, pharmaceutical, food safety, and animal health industries. We provide customized and flexible oligonucleotide GMP or non-GMP production services to meet different production needs.
Lipid Nanoparticle(LNP) for RNA Delivery
BOC Sciences offers comprehensive LNP- mRNA delivery services tailored to meet the specific needs of mRNA vaccine development. Our expertise in nanoparticle formulation and mRNA chemistry enables us to design custom LNP formulations optimized for stability, efficacy, and safety.
BOC Sciences promises to offer you with GalNAc-siRNA conjugation services to help you conduct further research on GalNAc-siRNA conjugates and explore their mores omnics capabilities, the working mechanism as well as their potential therapeutic profiles.
BOC Sciences offers aptamer customization services to generate high-quality aptamers tailored to your goals, delivering excellent results even for the most difficult target molecules.
Peptide-Oligonucleotide Conjugation
BOC Sciences is committed to providing our customers with comprehensive modification and labeling, offering affordable custom oligonucleotides or peptide-oligonucleotide conjugates.