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RNA therapies are a successful new approach in medicine, providing unprecedented precision in the treatment of a wide range of diseases. RNA-based therapies, including small interfering RNAs (siRNAs) and messenger RNAs (mRNAs), have emerged as new ways to treat or prevent disease. As a pioneer in pharmaceutical services, BOC Sciences demonstrated the industry's most cutting-edge RNA drug delivery systems that can facilitate the rapid development of life-saving RNA therapies.
What is a Drug Delivery System?
A drug delivery system is an agent or device that is a natural way to introduce a therapeutic substance, such as a therapeutic drug or imaging agent, into the body. In RNA therapeutics, drug delivery systems are critical for protecting RNA drug molecules and directing them safely into target cells. These systems must protect the RNA from degradation, facilitate cellular uptake, and release the therapeutic load at its site or range of action. The delivery of RNA-based therapies is highly dependent on the complexity and functionality of the system selected.
The Development of RNA Drugs
Naked RNA drugs will degrade rapidly as there are a large number of RNases in the blood, it will affect the drug efficacy of RNAi. Therefore, it's very important to improve the stability of naked RNA. Except for chemically modification, researchers are working hard on siRNA drug delivery system nowadays. Drug delivery system is becoming an important tool for delivering the candidate siRNA drugs to target cells. In August 2018, the US FDA approved the first siRNA drug, called ONPATTRO™ (Patisiran) by Alnylam Pharmaceuticals, for the treatment of hereditary transthyretin polyneuropathy. This was an important milestone for the field of siRNA drugs and opens the door for the research of other siRNA drug delivery system.
Drug Delivery Systems for RNA Therapeutics from BOC Sciences
BOC Sciences has developed a suite of advanced drug delivery systems tailored specifically for RNA therapeutics. Our systems are designed to address the unique challenges associated with RNA delivery, including stability, targeting, and efficient cellular uptake. Here, we discuss some of the key delivery systems offered by BOC Sciences.
Lipid Nanoparticle
BOC Sciences specializes in providing you with fully validated LNP delivery systems for nucleic acids, especially siRNA and mRNA, to induce functional protein expression and to study the potential of mRNA and LNP-based gene therapy.
BOC Sciences is dedicated to assisting you in exploring the complexity of liposomes, nucleic acid delivery mechanisms, and applications through our cutting-edge liposome delivery services.
Liposomes
Exosome
BOC Sciences is dedicated to further investigating and developing innovative exosomes delivery systems, which have been successfully applied to deliver various drugs, particularly nucleic acid (DNA/RNA) therapeutics.
BOC Sciences offers cationic nanoemulsion-based mRNA delivery systems, promising a one-stop service from mRNA synthesis to cationic nanoemulsion encapsulation to efficiently assist our customers in vaccine development and production.
Cationic Nanoemulsions
Cationic Polypeptides
BOC Sciences offers fully validated cationic peptide mRNA delivery systems to assist customers in further research into the efficacy, safety and long-term stability of mRNA vaccines.
BOC Sciences provides fully validated and optimised polymer complex mRNA delivery systems to assist customers in the development and production of mRNA vaccines for infectious disease and cancer control applications.
Polymer Complexes
Dynamic Polyconjugates (DPC)
BOC Sciences is committed to providing siRNA drug design and in vivo delivery solutions for drug development, solving our clients' research challenges.
BOC Sciences specializes in the design and development of diverse siRNA conjugate delivery systems, offering tailored solutions that improve the pharmacokinetics, target specificity, and overall effectiveness of siRNA therapies.
siRNA Conjugates
Need a Consultation on Custom Nucleic Acid Delivery Systems?
RNA experts from BOC Sciences are ready to provide you with detailed assistance.
Get A QuoteAdvantages of BOC Sciences' RNA Drug Delivery System
BOC Sciences stands out as a premier provider of RNA drug delivery systems because of the following widely acclaimed advantages.
Expertise and Innovation
With over 20 years of hands-on experience in the pharmaceutical industry, BOC Sciences has the expertise and capabilities to support your peptide therapeutic development program. We do this by researching and developing a novel class of drugs with revolutionary RNA therapeutic potential.
Customization and Flexibility
We recognize that each RNA therapeutic requires a unique delivery mechanism, and BOC Sciences can provide a variety of delivery options based on your needs. From fine-tuning the formulation of specific RNA molecules to creating novel delivery platforms, we offer a variety of options to ensure success.
Comprehensive Support
BOC Sciences leverages its state-of-the-art facilities and cutting-edge technology to specialize in the development and production of RNA delivery systems, providing superior solutions, products, and services on a global scale. From formulation development to large-scale manufacturing, we offer end-to-end support for RNA drug delivery, assisting clients in advancing nucleotide drug development. Our proprietary capabilities include analytical characterization, stability testing, and regulatory support, ensuring a seamless transition from discovery to preclinical applications.
Proven Track Record
Our RNA delivery systems have been validated in numerous preclinical studies, demonstrating their efficacy and safety. BOC Sciences' commitment to quality and performance is reflected in the success of our delivery platforms in various therapeutic areas.
Effective delivery of RNA therapeutics is critical to realize their full therapeutic potential. In the synthesis of RNA therapeutics, BOC Sciences leads its business by providing many suitable delivery platforms for various types of them (e.g., small interfering RNA) to deal with potential additional conditions. From lipid nanoparticles to exosome-based systems, our innovative approach ensures efficient and effective delivery of RNA molecules. With a wealth of knowledge, customizable solutions and a history of successful cases, BOC Science is the partner to drive your RNA therapy from the lab to the preclinical.
