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Cap Analogs

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Guanosine 5'-diphosphate disodium salt

Description: Guanosine 5'-diphosphate disodium salt is an imperative biomolecule esteemed in the biomedical sector, exhibiting noteworthy involvement in cellular signaling and serves as a substrate for diverse nucleic acid metabolism-encompassing enzymes. Its significance is exemplified through extensive employment in research and manufacturing, enabling comprehensive exploration of G-protein coupled receptors, protein synthesis and drug discovery-related signaling pathways, as well as disease research.
CAT: BRP-00036
CAS: 7415-69-2
MF: C10H13N5Na2O11P2
MF: 487.16
Purity: 98%
Appearance: White to Off-white Solid
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Storage: Store at -20 °C, under inert atmosphere
Melting Point: >280 °C (dec.)
Boiling Point: 961 °C at 760 mmHg
InChIKey: LTZCGDIGAHOTKN-LGVAUZIVSA-L
Solubility: Slightly soluble in Methanol (Heated), Water
CanonicalSMILES: C1=NC2=C(N1C3C(C(C(O3)COP(=O)([O-])OP(=O)(O)[O-])O)O)NC(=NC2=O)N.[Na+].[Na+]
IUPAC Name: disodium;[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] hydrogen phosphate
InChI: InChI=1S/C10H15N5O11P2.2Na/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21;;/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18);;/q;2*+1/p-2/t3-,5-,6-,9-;;/m1../s1
Synonyms: GDP-Na2; Disodium 5'-O-{[(hydroxyphosphinato)oxy]phosphinato}guanosine; GDP.Na2; 5'-GDP-Na2; Guanosine 5'-(trihydrogen diphosphate), disodium salt; Guanosinepyrophosphate, disodium salt; Disodium guanosine 5'-diphosphate; Guanosine-5'-diphosphoric acid disodium salt
Related CAS: 146-91-8 (free acid)

2'-O-Methyladenosine

Description: 2'-O-Methyladenosine is a modified nucleoside where a methyl group is attached to the 2' hydroxyl of the ribose sugar. This modification enhances the stability and binding affinity of RNA molecules, making it valuable in research focused on RNA structure, function, and therapeutic development. It is commonly used in the synthesis of chemically modified RNA for studies in molecular biology and biotechnology.
CAT: BRP-00066
CAS: 2140-79-6
MF: C11H15N5O4
MF: 281.27
Purity: ≥95%
Appearance: White to Off-white Solid
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Storage: Store at 2-8°C
Density: 1.84±0.1 g/cm3 (Predicted)
Melting Point: 198-200°C
Boiling Point: 623.8±65.0°C (Predicted)
Symbol: Am
InChIKey: FPUGCISOLXNPPC-IOSLPCCCSA-N
Solubility: Soluble in DMSO (Slightly), Methanol (Slightly, Heated, Sonicated), Water (Slightly)
CanonicalSMILES: COC1C(C(OC1N2C=NC3=C(N=CN=C32)N)CO)O
IUPAC Name: (2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-2-(hydroxymethyl)-4-methoxyoxolan-3-ol
InChI: InChI=1S/C11H15N5O4/c1-19-8-7(18)5(2-17)20-11(8)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17-18H,2H2,1H3,(H2,12,13,14)/t5-,7-,8-,11-/m1/s1
Synonyms: Adenosine, 2'-O-methyl-; (2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-2-(hydroxymethyl)-4-methoxytetrahydrofuran-3-ol; Cordysinin B; 2'-O-Methyl-D-adenosine; 2'-O-Me-adenosine; 2'-(O-Methyl) Adenosine; 2'-O-Me-Ado

m7G(5')ppp(5')(2'-OMeA)pG ammonium salt

Description: m7GpppAmpG ammonium is a trinucleotide 5′ cap analog with the capping efficiencies for the obtained RNAs of 90%.
CAT: BRP-00099
MF: C32H43N15O24P4 (free acid)
MF: 1145.66 (free acid)
Purity: ≥97% by HPLC
Appearance: Clear to slightly yellow Liquid
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Storage: Store at -20 °C
Synonyms: m7GpppAmpG ammonium salt; Adenosine 5'-(tetrahydrogen triphosphate), guanylyl-(5'→3')-2'-O-methyl-, P''→5'-ester with 2-amino-6,9-dihydro-7-methyl-6-oxo-9-β-D-ribofuranosyl-1H-purinium inner salt, ammonium salt; m7GpppA2'OmepG ammonium salt; GAG; GAG ammonium salt; m7G(5')ppp(5')(2'OMeA)pG ammonium salt
Related CAS: 62858-30-4 (free acid) ; 2941382-07-4 (trisodium salt) ; 2710263-09-3 (triammonium salt)

m7(3'OMeG)(5')ppp(5')(2'OMeA)pG ammonium salt

Description: Used for in vitro transcription of 5'-capped mRNA to produce a Cap 1 structure. EZ Cap reagent AG 3'OMe should be used with the specific starting sequence 5'AG 3'.
CAT: BRP-00100
MF: C33H45N15O24P4 (free acid)
MF: 1159.71 (free acid)
Purity: ≥97% by HPLC
Appearance: Clear to slightly yellow Liquid
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Storage: Store at -20 °C
Solubility: Soluble in Water
Synonyms: (3'-OMe-m7G)(5')ppp(5')(2'-OMeA)pG ammonium salt; 3'Ome-m7GpppAmpG ammonium salt; Guanosine, 7-methyl-3'-O-methylguanylyloxyphosphinicooxyphosphinico-(5'→5')-2'-O-methyladenylyl-(3'→5')-, inner salt, ammonium salt; m7(3'OMeG)(5')ppp(5')(2'OMeA)pG ammonium salt; CAP GAG (3'OMe) ammonium salt
Related CAS: 2089461-55-0 (free acid) ; 2863631-10-9 (trisodium salt)

m7GP3G (Monomethylated Cap Analog) sodium salt

Description: m7GP3G (Monomethylated Cap Analog) sodium salt is a vital product in the biomedical industry used for studying mRNA capping and translation initiation. It serves as a crucial tool for investigating RNA transcription, translation processes and mRNA stability. By mimicking the natural RNA cap structure, m7GP3G sodium salt aids in understanding diseases like cancer and viral infections, ultimately enabling the development of effective researchs.
CAT: BRP-00101
MF: C21H29N10O18P3 (free acid)
MF: 802.43 (free acid)
Purity: ≥95% by HPLC
Appearance: Colorless to Slightly Yellow Liquid
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Storage: Store at -20°C
IUPAC Name: 2-amino-9-((2R,3R,4S,5R)-5-((((((((((2R,3S,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)oxidophosphoryl)oxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)-7-methyl-6-oxo-6,9-dihydro-1H-purin-7-ium;sodium
Synonyms: m7G(5')ppp(5')G Sodium salt; P1-(5'-7-methyl-guanosyl) P3-(5'-(guanosyl))triphosphate, sodium salt; M7-GpppG sodium salt; Guanosine 5'-(tetrahydrogen triphosphate), P''→5'-ester with 2-amino-6,9-dihydro-7-methyl-6-oxo-9-β-D-ribofuranosyl-1H-purinium inner salt, sodium salt; m7Gp3G sodium salt; m7GpppG sodium salt; mCAP sodium salt
Related CAS: 75252-12-9 (diammonium salt) ; 1644684-21-8 (triammonium salt) ; 1577228-60-4 (x-ammonium salt) ; 130944-80-8 (disodium salt) ; 62828-64-2 (free acid)

m7GP3G (Monomethylated Cap Analog)

Description: m7GP3G (Monomethylated Cap Analog) is an indispensable compound extensively employed, supporting the synthesis of mRNAs possessing altered RNA cap structures. This remarkable compound assumes a pivotal function in advancing studies pertaining to gene expression and mRNA processing, particularly in the progressive frontiers of RNA vaccines and mRNA therapeutics. By enabling investigation into cap-dependent translation mechanisms, as well as facilitating the evaluation of mRNA stability and translational efficiency, this product fosters an unprecedented comprehension of intricate cellular processes.
CAT: BRP-00102
CAS: 62828-64-2
MF: C21H29N10O18P3
MF: 802.43
Purity: ≥95% by HPLC
Appearance: solid
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Storage: Store at -20 °C
InChIKey: FHHZHGZBHYYWTG-INFSMZHSSA-N
CanonicalSMILES: CN1C=[N+](C2=C1C(=O)N=C(N2)N)C3C(C(C(O3)COP(=O)([O])OP(=O)(O)OP(=O)(O)OCC4C(C(C(O4)N5C=NC6=C5NC(=NC6=O)N)O)O)O)O
IUPAC Name: [[(2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-9-ium-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphate
InChI: InChI=1S/C21H29N10O18P3/c1-29-5-31(15-9(29)17(37)28-21(23)26-15)19-13(35)11(33)7(47-19)3-45-51(40,41)49-52(42,43)48-50(38,39)44-2-6-1 (32)12(34)18(46-6)30-4-24-8-14(30)25-20(22)27-16(8)36/h4-7,10-13,18-19,32-35H,2-3H2,1H3 (H8-,22,23,25,26,27,28,36,37,38,39,40,41,42,43)/t6-,7-,10-,11-,12-,13-,18-,19-/m1/s1
Synonyms: Guanosine 5'-(tetrahydrogen triphosphate), P''→5'-ester with 2-amino-6,9-dihydro-7-methyl-6-oxo-9-β-D-ribofuranosyl-1H-purinium inner salt; m7Gp3G; m7GpppG; mG(5')ppp(5')G; P1-(5'-7-methyl-guanosyl) P3-(5'-(guanosyl))triphosphate; mCAP; m7G(5')ppp(5')G Cap Analog; N7-Methyl-Guanosine-5'-Triphosphate-5'-Guanosine; 7-Methyl-guanosine-5'-triphosphate-5'-guanosine; M7-GpppG
Related CAS: 75252-12-9 (diammonium salt) ; 1644684-21-8 (triammonium salt) ; 1577228-60-4 (x-ammonium salt)

ARCA ammonium salt

Description: m27,3'-OGP3G (ARCA Cap Analog) - solution is a valuable tool in the biomedical field, specifically in drug discovery and gene expression studies. m27,3'-OGP3G acts as an efficient cap analog, promoting mRNA capping reactions in various experimental settings. It finds applications in RNA synthesis, mRNA translation and cellular processes related to RNA metabolism. Its utility extends to investigating viral infections, cancer therapeutics and molecular biology research.
CAT: BRP-00120
MF: C22H31N10O18P3 (free acid)
MF: 816.46 (free acid)
Purity: ≥95% by HPLC
Appearance: Clear colorless Liquid
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Storage: Store at -20 °C
Synonyms: ARCA Ammonium; Anti Reverse Cap Analog ammonium salt; m7(3'-O-methy)G(5')ppp(5')G ammonium salt; 3'-O-Me-m7G(5')ppp(5')G ammonium salt; m27, 3'-OGP3G (ARCA Cap Analog) ammonium salt; 3'-O-Methyl-m7GpppG ammonium salt; ARCA (anti-reverse cap analog) ammonium salt; m27,3'OGpppG ammonium salt; N7-Methyl-3'-O-Methyl-Guanosine-5'-Triphosphate-5'-Guanosine ammonium salt
Related CAS: 400806-46-4 (free acid) ; 400806-60-2 (trisodium salt)

m27,3'-OGP3G (ARCA Cap Analog)

Description: m27,3'-OGP3G (ARCA Cap Analog), renowned for its exceptional properties, is a cap analog. Its omnipresence is felt in various research arenas, permeating the realms of mRNA structure investigation, protein interactions exploration and viral replication mechanism elucidation.
CAT: BRP-00121
CAS: 400806-46-4
MF: C22H31N10O18P3
MF: 816.46
Purity: ≥95% by HPLC
Appearance: solid
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Storage: Store at -20 °C
InChIKey: AIRSQUYUYJSIIM-XPWFQUROSA-N
Solubility: Soluble in Water
CanonicalSMILES: CN1C=[N+](C2=C1C(=O)NC(=N2)N)C3C(C(C(O3)COP(=O)([O-])OP(=O)(O)OP(=O)(O)OCC4C(C(C(O4)N5C=NC6=C5N=C(NC6=O)N)O)O)OC)O
IUPAC Name: [(2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-9-ium-9-yl)-4-hydroxy-3-methoxyoxolan-2-yl]methyl [[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl] phosphate
InChI: InChI=1S/C22H31N10O18P3/c1-30-6-32(16-10(30)18(37)29-22(24)27-16)20-13(35)14(44-2)8(48-20)4-46-52(40,41)50-53(42,43)49-51(38,39)45-3-7-11(33)12(34)19(47-7)31-5-25-9-15(31)26-21(23)28-17(9)36/h5-8,11-14,19-20,33-35H,3-4H2,1-2H3,(H8-,23,24,26,27,28,29,36,37,38,39,40,41,42,43)/t7-,8-,11-,12-,13-,14-,19-,20-/m1/s1
Synonyms: mG(5')ppp(5')G; P-(5'-(3'-O-methyl)-7-methyl-guanosyl), P-(5'-(guanosyl))triphosphate; Guanosine 5'-(tetrahydrogen triphosphate), 7-methyl-3'-O-methyl-, inner salt, P''→5'-ester with guanosine; 3'-O-Methyl-m7GpppG; ARCA; ARCA (anti-reverse cap analog); m27,3'OGpppG; N7-Methyl-3'-O-Methyl-Guanosine-5'-Triphosphate-5'-Guanosine
Related CAS: 400806-60-2 (Trisodium salt)

GP3G (Unmethylated Cap Analog)

Description: GP3G is a kind of diguanosine polyphosphate, could be found in human plasma.
CAT: BRP-00208
CAS: 6674-45-9
MF: C20H27N10O18P3
MF: 788.41
Purity: ≥95% by HPLC
Appearance: clear aqueous solution
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Storage: Store at -20 °C
Density: 2.7±0.1 g/cm3
Boiling Point: 1312.7±75.0 °C at 760 mmHg
InChIKey: AAXYAFFKOSNMEB-MHARETSRSA-N
CanonicalSMILES: C1=NC2=C(N1C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)OCC4C(C(C(O4)N5C=NC6=C5N=C(NC6=O)N)O)O)O)O)N=C(NC2=O)N
IUPAC Name: bis[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] hydrogen phosphate
InChI: InChI=1S/C20H27N10O18P3/c21-19-25-13-7(15(35)27-19)23-3-29(13)17-11(33)9(31)5(45-17)1-43-49(37,38)47-51(41,42)48-50(39,40)44-2-6-10(32)12(34)18(46-6)30-4-24-8-14(30)26-20(22)28-16(8)36/h3-6,9-12,17-18,31-34H,1-2H2,(H,37,38)(H,39,40)(H,41,42)(H3,21,25,27,35)(H3,22,26,28,36)/t5-,6-,9-,10-,11-,12-,17-,18-/m1/s1
Synonyms: GpppG; G(5')ppp(5')G Cap Analog; Diguanosine triphosphate; Diguanosine-5'-triphosphate; P1-(Guanosyl) P3-(5'-(guanosyl))triphosphate; CAP; Guanosine 5'-(tetrahydrogen triphosphate), P''→5'-ester with guanosine; Guanosine 5'-(tetrahydrogen triphosphate), 5'→5'-ester with guanosine; Guanosine triphosphate, 5'→5'-ester with guanosine; Guanosine, 5'-ester with guanosine 5'-(tetrahydrogen triphosphate); Diguanosine 5',5'''-triphosphate; Gp3G; P1,P3-Diguanosine 5'-triphosphate; Guanosine-5'-triphosphate-5'-Guanosine
Related CAS: 102783-44-8 (triammonium salt) ; 1314754-91-0 (trisodium salt)

Guanosine 5'-triphosphate-5'-adenosine

Description: Guanosine 5'-triphosphate-5'-adenosine, the 5′ cap analog, is a fluorescent substrate analog.
CAT: BRP-00209
CAS: 10527-47-6
MF: C20H27N10O17P3
MF: 772.41
Purity: ≥95% by HPLC
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Storage: Store at -20 °C
Density: 2.61±0.1 g/cm3
InChIKey: PMJUJCUPNRCBNP-INFSMZHSSA-N
CanonicalSMILES: C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)OCC4C(C(C(O4)N5C=NC6=C5N=C(NC6=O)N)O)O)O)O)N
IUPAC Name: [[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] hydrogen phosphate
InChI: InChI=1S/C20H27N10O17P3/c21-14-8-15(24-3-23-14)29(4-25-8)18-12(33)10(31)6(44-18)1-42-48(36,37)46-50(40,41)47-49(38,39)43-2-7-11(32)13(34)19(45-7)30-5-26-9-16(30)27-20(22)28-17(9)35/h3-7,10-13,18-19,31-34H,1-2H2,(H,36,37)(H,38,39)(H,40,41)(H2,21,23,24)(H3,22,27,28,35)/t6-,7-,10-,11-,12-,13-,18-,19-/m1/s1
Synonyms: GpppA; Guanosine 5'-(tetrahydrogen triphosphate), P''→5'-ester with adenosine; Adenosine 5'-(tetrahydrogen triphosphate), 5'→5'-ester with guanosine; Guanosine 5'-(tetrahydrogen triphosphate), 5'→5'-ester with adenosine; Guanosine triphosphate, 5'→5'-ester with adenosine; Gp3A; Gp3A (dinucleotide); P1-Adenosine-5' P3-guanosine-5' triphosphate
Related CAS: 1613387-42-0 (trisodium salt)

N7-Methyl-guanosine-5'-triphosphate-5'-adenosine

Description: N7-Methyl-guanosine-5’-triphosphate-5’-adenosine (m7GpppA) is a dinucleotide cap analog that can be used for in vitro RNA transcription.
CAT: BRP-00210
CAS: 62828-63-1
MF: C21H29N10O17P3
MF: 786.43
Purity: ≥95% by HPLC
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Storage: Store at -20°C
InChIKey: QQOHNVHGNZYSBP-XPWFQUROSA-N
CanonicalSMILES: CN1C=[N+](C2=C1C(=O)NC(=N2)N)C3C(C(C(O3)COP(=O)([O-])OP(=O)(O)OP(=O)(O)OCC4C(C(C(O4)N5C=NC6=C(N=CN=C65)N)O)O)O)O
IUPAC Name: [(2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-9-ium-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl [[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl] phosphate
InChI: InChI=1S/C21H29N10O17P3/c1-29-6-31(17-10(29)18(36)28-21(23)27-17)20-14(35)12(33)8(46-20)3-44-50(39,40)48-51(41,42)47-49(37,38)43-2-7-11(32)13(34)19(45-7)30-5-26-9-15(22)24-4-25-16(9)30/h4-8,11-14,19-20,32-35H,2-3H2,1H3,(H7-,22,23,24,25,27,28,36,37,38,39,40,41,42)/t7-,8-,11-,12-,13-,14-,19-,20-/m1/s1
Synonyms: M7-GpppA; Guanosine 5'-(tetrahydrogen triphosphate), 7-methyl-, inner salt, P''→5'-ester with adenosine; 7-Methylguanosine 5'-(tetrahydrogen triphosphate) inner salt, P''→5'-ester with adenosine; Adenosine 5'-(tetrahydrogen triphosphate), P''→5'-ester with 2-amino-6,9-dihydro-7-methyl-6-oxo-9-β-D-ribofuranosyl-1H-purinium inner salt; m7GpppA
Related CAS: 75252-10-7 (diammonium salt)

ARCA Sodium

Description: ARCA Sodium, a potent inhibitor of the Nav1.5 cardiac sodium channel, is adeptly utilized in mitigating arrhythmias, such as atrial fibrillation. Additionally, it exhibits promise as a therapeutic agent for the management of chronic pain conditions.
CAT: BRP-00211
MF: C22H31N10O18P3 (free acid)
MF: 816.46 (free acid)
Purity: ≥95% by HPLC
Appearance: Clear colorless to faint yellow Liquid
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Storage: Store at -20°C
Synonyms: ARCA, sodium salt; Anti Reverse Cap Analog sodium salt; m7(3'-O-methy)G(5')ppp(5')G sodium salt; 3'-O-Me-m7G(5')ppp(5')G sodium salt; m27, 3'-OGP3G (ARCA Cap Analog) sodium salt; 3'-O-Methyl-m7GpppG sodium salt; ARCA (anti-reverse cap analog) sodium salt; m27,3'OGpppG sodium salt; N7-Methyl-3'-O-Methyl-Guanosine-5'-Triphosphate-5'-Guanosine, sodium salt
Related CAS: 400806-46-4 (free acid) ; 400806-60-2 (trisodium salt)

M7G(3'-OMe-5')pppA(2'-OMe)

Description: M7G(3'-OMe-5')pppA(2'-OMe) is a cap analogue for mRNA synthesis in vitro.
CAT: BRP-00212
MF: C23H33N10O17P3
MF: 814.49
Purity: ≥95% by HPLC
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Storage: Store at -20 °C
InChIKey: CDTPPKGWEOGAMN-LAMCKDNKSA-N
IUPAC Name: 2-amino-9-((2R,3R,4S,5R)-5-((((((((((2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxy-4-methoxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)oxidophosphoryl)oxy)methyl)-3-hydroxy-4-methoxytetrahydrofuran-2-yl)-7-methyl-6-oxo-6,9-dihydro-1H-purin-7-ium
InChI: InChI=1S/C23H33N10O17P3/c1-31-8-33(19-12(31)20(36)30-23(25)29-19)21-14(35)15(43-2)10(48-21)5-46-52(39,40)50-53(41,42)49-51(37,38)45-4-9-13(34)16(44-3)22(47-9)32-7-28-11-17(24)26-6-27-18(11)32/h6-10,13-16,21-22,34-35H,4-5H2,1-3H3,(H7-,24,25,26,27,29,30,36,37,38,39,40,41,42)/t9-,10-,13-,14-,15-,16-,21-,22-/m1/s1
Synonyms: (3'-OMe-m7G)(5')ppp(5')(2'-OMe-A)

m7GpppAmpG

Description: m7GpppAmpG is a trinucleotide 5' cap analog with the capping efficiencies for the obtained RNAs of 90%. It is used to transcribe 5'cap mRNA in vitro to produce the Cap 1 structure, which is more suitable for mammalian systems and has higher transcriptional efficiency than the Cap 0 structure. m7GpppAmpG Cap Analog is a co-transcriptional capping agent that transcribes 5' capped mRNA in vitro to form the Cap 1 structure.
CAT: BRP-00215
CAS: 62858-30-4
MF: C32H43N15O24P4
MF: 1145.67
Purity: ≥95% by HPLC
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Storage: Store at -20 °C
InChIKey: AGWRKMKSPDCRHI-UQTMIEBXSA-N
CanonicalSMILES: CN1C=[N+](C2=C1C(=O)NC(=N2)N)C3C(C(C(O3)COP(=O)([O-])OP(=O)(O)OP(=O)(O)OCC4C(C(C(O4)N5C=NC6=C(N=CN=C65)N)OC)OP(=O)(O)OCC7C(C(C(O7)N8C=NC9=C8N=C(NC9=O)N)O)O)O)O
IUPAC Name: [(2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-9-ium-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl [[[(2R,3R,4R,5R)-3-[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)-4-methoxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl] phosphate
InChI: InChI=1S/C32H43N15O24P4/c1-44-9-47(25-15(44)27(53)43-32(35)41-25)29-19(51)17(49)11(67-29)4-64-73(56,57)70-75(60,61)71-74(58,59)65-5-12-20(21(62-2)30(68-12)45-7-38-13-22(33)36-6-37-23(13)45)69-72(54,55)63-3-10-16(48)18(50)28(66-10)46-8-39-14-24(46)40-31(34)42-26(14)52/h6-12,16-21,28-30,48-51H,3-5H2,1-2H3,(H11-,33,34,35,36,37,40,41,42,43,52,53,54,55,56,57,58,59,60,61)/t10-,11-,12-,16-,17-,18-,19-,20-,21-,28-,29-,30-/m1/s1
Synonyms: m7G(5')ppp(5')(2'-OMeA)pG; GAG; Guanosine, 7-methylguanylyloxyphosphinicooxyphosphinico-(5'→5')-2'-O-methyladenylyl-(3'→5')-, inner salt; Adenosine 5'-(tetrahydrogen triphosphate), guanylyl-(5'→3')-2'-O-methyl-, P''→5'-ester with 2-amino-6,9-dihydro-7-methyl-6-oxo-9-β-D-ribofuranosyl-1H-purinium inner salt; m7GpppA2'OmepG
Related CAS: 2941382-07-4 (trisodium salt) ; 2710263-09-3 (triammonium salt)

3'Ome-m7GpppAmpG

Description: 3'Ome-m7GpppAmpG is a trinucleotide Cap analogue containing a locked nucleic acid ( LNA ) molecule. 3'Ome-m7GpppAmpG shows a significant translational efficiency. 3'Ome-m7GpppAmpG can be used as a potential molecular biology tool in the field of mRNA vaccines and mRNA transfection, such as protein production, gene therapy and anti-cancer immunization.
CAT: BRP-00216
CAS: 2089461-55-0
MF: C33H45N15O24P4
MF: 1159.69
Purity: ≥95% by HPLC
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Storage: Store at -20 °C
InChIKey: QLKZOMAEOBMBOC-RKTALREWSA-N
CanonicalSMILES: CN1C=[N+](C2=C1C(=O)NC(=N2)N)C3C(C(C(O3)COP(=O)([O-])OP(=O)(O)OP(=O)(O)OCC4C(C(C(O4)N5C=NC6=C(N=CN=C65)N)OC)OP(=O)(O)OCC7C(C(C(O7)N8C=NC9=C8N=C(NC9=O)N)O)O)OC)O
IUPAC Name: [(2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-9-ium-9-yl)-4-hydroxy-3-methoxyoxolan-2-yl]methyl [[[(2R,3R,4R,5R)-3-[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)-4-methoxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl] phosphate
InChI: InChI=1S/C33H45N15O24P4/c1-45-10-48(26-16(45)28(53)44-33(36)42-26)30-19(51)20(62-2)12(68-30)5-65-74(56,57)71-76(60,61)72-75(58,59)66-6-13-21(22(63-3)31(69-13)46-8-39-14-23(34)37-7-38-24(14)46)70-73(54,55)64-4-11-17(49)18(50)29(67-11)47-9-40-15-25(47)41-32(35)43-27(15)52/h7-13,17-22,29-31,49-51H,4-6H2,1-3H3,(H11-,34,35,36,37,38,41,42,43,44,52,53,54,55,56,57,58,59,60,61)/t11-,12-,13-,17-,18-,19-,20-,21-,22-,29-,30-,31-/m1/s1
Synonyms: 3'-OMe-GAG; (3'-OMe-m7G)(5')ppp(5')(2'-OMeA)pG; m7(3'OMeG)(5')ppp(5')(2'OMeA)pG; Guanosine, 7-methyl-3'-O-methylguanylyloxyphosphinicooxyphosphinico-(5'→5')-2'-O-methyladenylyl-(3'→5')-, inner salt; m7(3'OMeG)(5')ppp(5')(2'OMeA)pG; CAP GAG (3'OMe)
Related CAS: 2863631-10-9 (trisodium salt)

m7G(5')ppp(5')(2'OMeA)pU

Description: A 5'cap analog used for co-transcriptional capping of mRNA. The product is specifically designed for self-replicating RNAs based on the genomes of positive sense strand RNA viruses such as Venezuelan equine encephalitis virus (VEEV), Semliki forest virus (SFV), and Sindbis virus (SIN).
CAT: BRP-00217
CAS: 2734858-38-7
MF: C31H42N12O25P4
MF: 1106.63
Purity: ≥95% by HPLC
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InChIKey: FTIHNRSFQMJZNB-MPTQKLLZSA-N
Solubility: Store at -20°C
CanonicalSMILES: O=C1N=C(N)NC2=C1[N+](=CN2C3OC(COP(=O)([O-])OP(=O)(O)OP(=O)(O)OCC4OC(N5C=NC=6C(=NC=NC65)N)C(OC)C4OP(=O)(O)OCC7OC(N8C=CC(=O)NC8=O)C(O)C7O)C(O)C3O)C
IUPAC Name: 2-amino-9-((2R,3R,4S,5R)-5-((((((((((2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3-(((((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)-4-methoxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)oxidophosphoryl)oxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)-7-methyl-6-oxo-6,9-dihydro-1H-purin-7-ium
InChI: InChI=1S/C31H42N12O25P4/c1-40-10-43(25-16(40)26(49)39-30(33)38-25)28-20(48)18(46)12(64-28)6-61-70(53,54)67-72(57,58)68-71(55,56)62-7-13-21(22(59-2)29(65-13)42-9-36-15-23(32)34-8-35-24(15)42)66-69(51,52)60-5-11-17(45)19(47)27(63-11)41-4-3-14(44)37-31(41)50/h3-4,8-13,17-22,27-29,45-48H,5-7H2,1-2H3,(H9-,32,33,34,35,37,38,39,44,49,50,51,52,53,54,55,56,57,58)/t11-,12-,13-,17-,18-,19-,20-,21-,22-,27-,28-,29-/m1/s1
Synonyms: Uridine, 7-methylguanylyloxyphosphinicooxyphosphinico-(5'→5')-2'-O-methyladenylyl-(3'→5')-, inner salt; (m7)Gppp(5')(m2'O)ApU; m7G(5')ppp(5')(2'-OMeA)pU; m7Gppp(5')A2'OMepU; m7GpppAmpU trinucleotide cap; GAU
Related CAS: 2941382-10-9 (trisodium salt)

m7GpppGmpG

Description: m7GpppGmpG is a trinucleotide 5′ cap analog with the capping efficiencies for the obtained RNAs of 86%.
CAT: BRP-00327
CAS: 1258049-00-1
MF: C32H43N15O25P4
MF: 1161.66
Purity: ≥98%
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Storage: Store at -20 °C, Always avoid freeze-thaw cycles
InChIKey: CDWLIVSWBYRIEX-ZQWUJQRXSA-N
CanonicalSMILES: CN1C=[N+](C2=C1C(=O)NC(=N2)N)C3C(C(C(O3)COP(=O)([O-])OP(=O)(O)OP(=O)(O)OCC4C(C(C(O4)N5C=NC6=C5N=C(NC6=O)N)OC)OP(=O)(O)OCC7C(C(C(O7)N8C=NC9=C8N=C(NC9=O)N)O)O)O)O
IUPAC Name: [(2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-9-ium-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl [[[(2R,3R,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-4-methoxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl] phosphate
InChI: InChI=1S/C32H43N15O25P4/c1-44-8-47(23-14(44)26(54)43-32(35)40-23)28-18(51)16(49)10(68-28)4-65-74(57,58)71-76(61,62)72-75(59,60)66-5-11-19(20(63-2)29(69-11)46-7-37-13-22(46)39-31(34)42-25(13)53)70-73(55,56)64-3-9-15(48)17(50)27(67-9)45-6-36-12-21(45)38-30(33)41-24(12)52/h6-11,15-20,27-29,48-51H,3-5H2,1-2H3,(H12-,33,34,35,38,39,40,41,42,43,52,53,54,55,56,57,58,59,60,61,62)/t9-,10-,11-,15-,16-,17-,18-,19-,20-,27-,28-,29-/m1/s1
Synonyms: EZ Cap Reagent GG; EZ Cap Reagent GG for co-transcriptional capping of mRNA; m7G(5')ppp(5')(2'OMeG)pG; Guanosine, 7-methylguanylyloxyphosphinicooxyphosphinico-(5'→5')-2'-O-methylguanylyl-(3'→5')-, inner salt; m7Gppp(2'OMeG)pG; CAP GGG m7G(5')ppp(5')(2'OMeG)pG; GGG
Related CAS: 2638447-82-0 (tetraammonium salt) ; 2924872-05-7 (trisodium salt)

m7GpppGmpG ammonium salt

Description: m7GpppGmpG ammonium is a trinucleotide 5′ cap analog with the capping efficiencies for the obtained RNAs of 86%.
CAT: BRP-00328
MF: C32H43N15O25P4 (free acid)
MF: 1161.67 (free acid)
Purity: ≥98%
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Storage: Store at -20 °C, Always avoid freeze-thaw cycles
Synonyms: CAP GGG m7G(5')ppp(5')(2'OMeG)pG 100mM Ammonium; CAP GGG m7G(5')ppp(5')(2'OMeG)pG Ammonium salt; GGG Ammonium salt; m7G(5')ppp(5')(2'OMeG)pG Ammonium salt; m7Gppp(2'OMeG)pG Ammonium salt
Related CAS: 1258049-00-1 (free acid) ; 2638447-82-0 (tetraammonium salt) ; 2924872-05-7 (trisodium salt)

m7(3'OMeG)(5')ppp(5')(2'OMeG)pG

Description: EZ Cap Reagent GG (3'OMe) is a co-transcription capping reagent.
CAT: BRP-00329
CAS: 2089461-54-9
MF: C33H45N15O25P4
MF: 1175.69
Purity: ≥95% by AX-HPLC
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Storage: Store at -20°C
InChIKey: UIMYJBJWBAHYJD-UQTMIEBXSA-N
CanonicalSMILES: CN1C=[N+](C2=C1C(=O)NC(=N2)N)C3C(C(C(O3)COP(=O)([O-])OP(=O)(O)OP(=O)(O)OCC4C(C(C(O4)N5C=NC6=C5N=C(NC6=O)N)OC)OP(=O)(O)OCC7C(C(C(O7)N8C=NC9=C8N=C(NC9=O)N)O)O)OC)O
IUPAC Name: [(2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-9-ium-9-yl)-4-hydroxy-3-methoxyoxolan-2-yl]methyl [[[(2R,3R,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-4-methoxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl] phosphate
InChI: InChI=1S/C33H45N15O25P4/c1-45-9-48(24-15(45)27(54)44-33(36)41-24)29-18(51)19(63-2)11(69-29)5-66-75(57,58)72-77(61,62)73-76(59,60)67-6-12-20(21(64-3)30(70-12)47-8-38-14-23(47)40-32(35)43-26(14)53)71-74(55,56)65-4-10-16(49)17(50)28(68-10)46-7-37-13-22(46)39-31(34)42-25(13)52/h7-12,16-21,28-30,49-51H,4-6H2,1-3H3,(H12-,34,35,36,39,40,41,42,43,44,52,53,54,55,56,57,58,59,60,61,62)/t10-,11-,12-,16-,17-,18-,19-,20-,21-,28-,29-,30-/m1/s1
Synonyms: EZ Cap Reagent GG (3' OMe) for co-transcriptional capping of mRNA; EZ Cap Reagent GG (3' OMe); GGG(3'OMe); m7(3'OMeG)ppp(2'OMeG)pG
Related CAS: 2924872-08-0 (trisodium salt)

m7Gpppm6AmpG

Description: m7Gpppm6AmpG is a trinucleotide mRNA 5’ cap analogs. m7Gpppm6AmpG can be used for RNA synthesis in vitro.
CAT: BRP-00330
CAS: 71340-22-2
MF: C33H45N15O24P4
MF: 1159.69
Purity: ≥98%
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Storage: Store at -20 °C, Always avoid freeze-thaw cycles
InChIKey: DIMGFCCAJKOSNT-RKTALREWSA-N
CanonicalSMILES: CNC1=C2C(=NC=N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)([O-])OCC4C(C(C(O4)[N+]5=CN(C6=C5N=C(NC6=O)N)C)O)O)OP(=O)(O)OCC7C(C(C(O7)N8C=NC9=C8N=C(NC9=O)N)O)O)OC
IUPAC Name: [(2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-9-ium-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl [[[(2R,3R,4R,5R)-3-[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-4-methoxy-5-[6-(methylamino)purin-9-yl]oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl] phosphate
InChI: InChI=1S/C33H45N15O24P4/c1-36-23-14-24(38-7-37-23)46(8-39-14)31-22(63-3)21(70-73(55,56)64-4-11-17(49)19(51)29(67-11)47-9-40-15-25(47)41-32(34)43-27(15)53)13(69-31)6-66-75(59,60)72-76(61,62)71-74(57,58)65-5-12-18(50)20(52)30(68-12)48-10-45(2)16-26(48)42-33(35)44-28(16)54/h7-13,17-22,29-31,49-52H,4-6H2,1-3H3,(H10-,34,35,36,37,38,41,42,43,44,53,54,55,56,57,58,59,60,61,62)/t11-,12-,13-,17-,18-,19-,20-,21-,22-,29-,30-,31-/m1/s1
Synonyms: Guanosine, 7-methylguanylyloxyphosphinicooxyphosphinico-(5'→5')-N-methyl-2'-O-methylguanylyl-(3'→5')-, inner salt; Adenosine 5'-(tetrahydrogen triphosphate), guanylyl-(5'→3')-N-methyl-2'-O-methyl-, P''→5'-ester with 2-amino-6,9-dihydro-7-methyl-6-oxo-9-β-D-ribofuranosyl-1H-purinium, inner salt; CAP GAG(m6A) m7G(5')ppp(5')(2'OMe,m6A)pG; GAG(m6A); m7Gppp(2'OMe,m6A)pG; m7G(5')ppp(5')(2'OMe,m6A)pG
Related CAS: 2956650-99-8 (trisodium salt)
* Only for research. Not suitable for any diagnostic or therapeutic use.

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