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What is RNA Interference?
RNA interference (RNAi) refers to the phenomenon of efficient and specific degradation of homologous mRNA induced by double-stranded RNA (dsRNA), which is highly conserved during evolution. It is an important tool for the study of gene function and is emerging as a tool for gene therapy research in viral diseases, genetic diseases and tumours. RNA interference (RNAi) technology uses double-stranded RNA to efficiently and specifically degrade intracellular homologous mRNAs to block the expression of target genes, resulting in a phenotype of target gene deletion.
How does RNA Interference Work?
After processing by Dicer (a nuclease with RNAase III activity), the longer double-stranded RNAs (above 30nt) in the cell are first degraded to form small interfering RNAs (siRNAs) of 21-25nt, which efficiently target the target mRNA. Thus, siRNAs are important intermediates for gene silencing and sequence-specific RNA degradation. The shorter double-stranded RNAs cannot be efficiently processed into siRNAs and therefore cannot mediate RNAi. siRNAs have a specific structural feature, namely a 5' end phosphate group and a 3' end hydroxyl group, with two bases protruding from the 3' end of each of its two strands. The antisense strand in siRNA guides the synthesis of a ribosome called RNA-induced silencing complex (RISC), and then RISC-mediated cleaves the region complementary to the siRNA antisense strand in the target mRNA molecule, thereby achieving interference function of target gene expression.
RNA Interference (RNAi) Services from BOC Sciences
BOC Sciences' RNAi Services team's technical expertise can help clients achieve maximum value from their RNAi technology and avoid a number of experimental errors. We are committed to providing the highest quality RNAi services for scientific research at the lowest price. BOC Sciences provides the following customized RNAi services for your scientific research:
Predesigned siRNA
BOC Sciences offers siRNA design services and a comprehensive predesigned siRNA library to meet research needs in biology and drug discovery.
Custom siRNA
BOC Sciences provides flexible siRNA synthesis scales & types to meet your individual research needs.
BOC Sciences can provide customers with common chemically synthesized siRNAs, as well as a wide range of modified siRNAs depending on customer requirements.
BOC Sciences' siRNA chimera customization service can solve your bottleneck problem in siRNA development to a certain extent.
BOC Sciences provides high-purity piRNAs based on continuously optimized RNA synthesis technologies to support basic research and pharmaceutical applications in the field of RNAi.
Modified siRNA
BOC Sciences provides comprehensive modifications for your personal research needs.
BOC Sciences provides high-quality and cost-effective siRNA with various chemical modifications and flexible synthesis scales to meet customers' needs.
BOC Sciences provides high-quality and cost-effective siRNA with various fluorescence labels and flexible synthesis scales to meet customers' needs.
DNA-Directed RNA Interference (ddRNAi) Services
BOC Sciences' ddRNAi service provides a precise, long-lasting, and efficient approach to gene silencing and expression regulation.
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RNAi Construction, Screening, Verification & Optimization Services
BOC Sciences can provide siRNA/shRNA/miRNA and other sequence design, and provide comprehensive gene expression solutions from siRNA synthesis, shRNA vector construction to related virus packaging, gene silencing function verification, etc.
BOC Sciences strives to be your preferred and trusted provider for siRNA screening services based on our advanced technology and experienced staff.
BOC Sciences has expertise in stable cell line construction and we can perform RNAi stable cell line screening services as required by our clients.
BOC Sciences uses real-time quantitative PCR to detect knock down effects at the mRNA level and Western blot to detect knock down effects at the protein level.
BOC Sciences' RNAi transfection optimization services include siRNA delivery optimization and plasmid transfection optimization.
siRNA-related Products from BOC Sciences
siRNA Products
BOC Sciences offers a wide range of high purity siRNA products and synthetic raw materials.
siRNA Control Products
BOC Sciences provides high-quality and effective siRNA positive and negative for the customers' control experiment.
siRNA Sets
BOC Sciences can provide customers with the siRNA packages. Each package contains three candidate siRNA targeted to the specific gene, and three siRNA controls, which are siRNA negative control, siRNA fluorescence-labeled negative control and siRNA positive control.
siRNA-related Resources
Advances in siRNA Drug Research
Therapeutic siRNA: Recent Advances and Prospects
Reviews of siRNA Nanocarriers for Blood-Brain Barrier(BBB) Penetration
How to Enhance the Promising Potential of siRNA Drugs
Advantages of BOC Sciences' siRNA Services
BOC Sciences stands out in the field of RNA interference due to our commitment to excellence and innovation.
Advanced Technology and Tools
We utilize state-of-the-art technology and bioinformatics tools for the design, synthesis, and validation of RNAi molecules. Our sophisticated algorithms and high-throughput screening platforms enhance the precision and efficiency of our RNAi services.
Customized Solutions
At BOC Sciences, we understand that each research or therapeutic project has unique requirements. We offer personalized solutions tailored to your specific needs, including custom RNAi design, specialized delivery systems, and comprehensive validation services.
Commitment to Quality
Quality is at the core of everything we do. Our RNAi services are backed by rigorous quality control measures and thorough validation processes. We are dedicated to delivering RNAi products and services that meet the highest standards of accuracy and reliability.
Support and Collaboration
BOC Sciences is committed to supporting our clients throughout their RNAi projects. We offer expert guidance, technical support, and collaborative opportunities to ensure the success of your research or therapeutic development.
BOC Sciences is your trusted partner for RNA interference services, providing comprehensive solutions that drive innovation and advance your research. Our expertise, advanced technology, and commitment to quality make us the ideal choice for all your RNAi needs. Please contact us for more information. Experimental details will help us provide an accurate quote.
* Only for research. Not suitable for any diagnostic or therapeutic use.
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GMP Oligonucleotide Manufacturing Service
For more than 15 years, BOC Sciences has been manufacturing oligonucleotides for pre-clinical, pharmaceutical, food safety, and animal health industries. We provide customized and flexible oligonucleotide GMP or non-GMP production services to meet different production needs.
Lipid Nanoparticle(LNP) for RNA Delivery
BOC Sciences offers comprehensive LNP- mRNA delivery services tailored to meet the specific needs of mRNA vaccine development. Our expertise in nanoparticle formulation and mRNA chemistry enables us to design custom LNP formulations optimized for stability, efficacy, and safety.
BOC Sciences promises to offer you with GalNAc-siRNA conjugation services to help you conduct further research on GalNAc-siRNA conjugates and explore their mores omnics capabilities, the working mechanism as well as their potential therapeutic profiles.
BOC Sciences offers aptamer customization services to generate high-quality aptamers tailored to your goals, delivering excellent results even for the most difficult target molecules.
Peptide-Oligonucleotide Conjugation
BOC Sciences is committed to providing our customers with comprehensive modification and labeling, offering affordable custom oligonucleotides or peptide-oligonucleotide conjugates.
