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As a class of nucleic acid molecules with short sequences, oligonucleotides are essential tools for regulating gene expression in life science and biomedical research. BOC Sciences provides you with high-quality and high-yield oligonucleotide conjugation through state-of-the-art synthesis platforms and expertise in oligonucleotide conjugates. According to strict quality assurance and quality control standards, BOC Sciences produces oligonucleotide modification and conjugation services with an extremely high degree of purity.
Introduction to Oligo Bioconjugation
What is Oligo Bioconjugation
The common thrust of oligonucleotide bioconjugation methods is to facilitate interactions between the conjugate and its corresponding cell surface receptor protein, leading to subsequent internalisation via receptor-mediated endocytosis, resulting in targeted drug delivery to specific tissues or to specific cell types within tissues. Bioconjugates interact with cell type-associated receptors to enable targeted drug delivery to specific tissues or specific cell types within tissues.
Fig. 1 Uptake routes of oligonucleotides conjugates. (Winkler, 2013)
Application of Oligo Bioconjugation
- Gene diagnostics
- Cancer therapy
- Molecular probes
- PCR primers
- Molecular tags
- etc.
Types of Oligo Bioconjugation
| Service Category | Description | |
| Peptide-Oligonucleotide Conjugation | Peptide-oligonucleotide conjugates (POCs) consist of one or more residues of a linear or less commonly cyclic peptide linked by covalent bonds to an oligonucleotide or its analog. | Inquiry |
| Antibody-Oligonucleotide Conjugation | Antibody-oligonucleotide conjugates (AOC) refer to the use of antibodies to deliver therapeutic oligonucleotides to specific cells or tissues, thereby reducing the amount of drug required to treat a patient's disease as well as solving the problem of untargetable and oligonucleotide delivery. | Inquiry |
| GalNAc-Oligonucleotide Conjugation | Conjugating GalNAc to oligonucleotides (siRNA, ASO, microRNA) to form GalNAc-oligonucleotide conjugates can achieve specific delivery of oligonucleotide drugs to the liver. | Inquiry |
| Protein-Oligonucleotide Conjugation | Conjugating proteins and oligonucleotides improve both the stability and the biological activity of the oligonucleotides. | Inquiry |
| Lipids-Oligonucleotide Conjugation | Lipid-oligonucleotide conjugates (LONs) have become an important topic for improving the safe delivery of oligonucleotides (ASO and siRNAs). | Inquiry |
| Enzyme-Oligonucleotide Conjugation | The direct conjugation of enzymes to oligonucleotides provides the best overall performance with the highest sensitivity, specificity, simplicity and rapid detection. | Inquiry |
| Metal Chelates-Oligonucleotide Conjugation | Metal chelates-oligonucleotide conjugation can be applied in radioimmunoassay (RIA), radioimmunotherapy (RIT), magnetic resonance imaging (MRI), etc. | Inquiry |
Oligo Bioconjugation Service Descriptions
- Material: Oligonucleotides and wide choice of target molecules (antibody, peptide, aptamer and etc.)
- Custom synthesis: BOC Sciences offers customized oligonucleotide sequence synthesis based on specific customer needs.
- Quality: QC analysis by MS, HPLC, or PAGE
- Delivery: Typical delivery is lyophilized samples in individual vials that are fully labeled
- Professional technical support: BOC Sciences' team of professional scientists can provide technical advice and support to solve any problems that customers may encounter during the oligonucleotide synthesis process.
- Reasonable prices: BOC Sciences is able to offer competitive prices while maintaining the high quality and reliability of its products.
References
- Winkler; et al. Oligonucleotide conjugates for therapeutic applications. Therapeutic Delivery. 2013, 4(7): 791-809.
- Gooding M; et al. Oligonucleotide conjugates - Candidates for gene silencing therapeutics. Eur J Pharm Biopharm. 2016 Oct; 107: 321-40.
* Only for research. Not suitable for any diagnostic or therapeutic use.
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GMP Oligonucleotide Manufacturing Service
For more than 15 years, BOC Sciences has been manufacturing oligonucleotides for pre-clinical, pharmaceutical, food safety, and animal health industries. We provide customized and flexible oligonucleotide GMP or non-GMP production services to meet different production needs.
Lipid Nanoparticle(LNP) for RNA Delivery
BOC Sciences offers comprehensive LNP- mRNA delivery services tailored to meet the specific needs of mRNA vaccine development. Our expertise in nanoparticle formulation and mRNA chemistry enables us to design custom LNP formulations optimized for stability, efficacy, and safety.
BOC Sciences promises to offer you with GalNAc-siRNA conjugation services to help you conduct further research on GalNAc-siRNA conjugates and explore their mores omnics capabilities, the working mechanism as well as their potential therapeutic profiles.
BOC Sciences offers aptamer customization services to generate high-quality aptamers tailored to your goals, delivering excellent results even for the most difficult target molecules.
Peptide-Oligonucleotide Conjugation
BOC Sciences is committed to providing our customers with comprehensive modification and labeling, offering affordable custom oligonucleotides or peptide-oligonucleotide conjugates.
