Oligonucleotide Conjugation Services

Oligonucleotide Conjugation Services

As a class of nucleic acid molecules with short sequences, oligonucleotides are essential tools for regulating gene expression in life science and biomedical research. BOC Sciences provides you with high-quality and high-yield oligonucleotide conjugation through state-of-the-art synthesis platforms and expertise in oligonucleotide conjugates. According to strict quality assurance and quality control standards, BOC Science produces oligonucleotide modification and conjugation services with an extremely high degree of purity.

Oligonucleotide Bioconjugation

Service CategoryDescription
Peptide-Oligonucleotide ConjugationPeptide-oligonucleotide conjugates (POCs) consist of one or more residues of a linear or less commonly cyclic peptide linked by covalent bonds to an oligonucleotide or its analog.Inquiry
Antibody-Oligonucleotide ConjugationAntibody-oligonucleotide conjugates (AOC) refer to the use of antibodies to deliver therapeutic oligonucleotides to specific cells or tissues, thereby reducing the amount of drug required to treat a patient's disease as well as solving the problem of untargetable and oligonucleotide delivery.Inquiry
GalNAc-Oligonucleotide ConjugationConjugating GalNAc to oligonucleotides (siRNA, ASO, microRNA) to form GalNAc-oligonucleotide conjugates can achieve specific delivery of oligonucleotide drugs to the liver.Inquiry
Protein-Oligonucleotide ConjugationConjugating proteins and oligonucleotides improve both the stability and the biological activity of the oligonucleotides.Inquiry
Lipids-Oligonucleotide ConjugationLipid-oligonucleotide conjugates (LONs) have become an important topic for improving the safe delivery of oligonucleotides (ASO and siRNAs).Inquiry
Enzyme-Oligonucleotide ConjugationThe direct conjugation of enzymes to oligonucleotides provides the best overall performance with the highest sensitivity, specificity, simplicity and rapid detection.Inquiry
Metal Chelates-Oligonucleotide ConjugationInquiry

Introduction

The common thrust of oligonucleotide bioconjugation methods is to facilitate interactions between the conjugate and its corresponding cell surface receptor protein, leading to subsequent internalisation via receptor-mediated endocytosis, resulting in targeted drug delivery to specific tissues or to specific cell types within tissues. Bioconjugates interact with cell type-associated receptors to enable targeted drug delivery to specific tissues or specific cell types within tissues.

Uptake routes of oligonucleotides conjugates. Fig. 1 Uptake routes of oligonucleotides conjugates. (Winkler, 2013)

Service Descriptions

  • Material: Oligonucleotides and wide choice of target molecules (antibody, peptide, aptamer and etc.)
  • Flexible synthesis scales
  • Quality: QC analysis by MS, HPLC, or PAGE
  • Delivery: Typical delivery is lyophilized samples in individual vials that are fully labeled

Advantages

  • Gene diagnostics
  • Cancer therapy
  • Molecular probes
  • PCR primers
  • Molecular tags
  • etc.

References

  1. Winkler; et al. Oligonucleotide conjugates for therapeutic applications. Therapeutic Delivery. 2013, 4(7): 791-809.
  2. Gooding M; et al. Oligonucleotide conjugates - Candidates for gene silencing therapeutics. Eur J Pharm Biopharm. 2016 Oct; 107: 321-40.
* Only for research. Not suitable for any diagnostic or therapeutic use.
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