As a class of nucleic acid molecules with short sequences, oligonucleotides are essential tools for regulating gene expression in life science and biomedical research. BOC Sciences provides you with high-quality and high-yield oligonucleotide conjugation through state-of-the-art synthesis platforms and expertise in oligonucleotide conjugates. According to strict quality assurance and quality control standards, BOC Sciences produces oligonucleotide modification and conjugation services with an extremely high degree of purity.
The common thrust of oligonucleotide bioconjugation methods is to facilitate interactions between the conjugate and its corresponding cell surface receptor protein, leading to subsequent internalisation via receptor-mediated endocytosis, resulting in targeted drug delivery to specific tissues or to specific cell types within tissues. Bioconjugates interact with cell type-associated receptors to enable targeted drug delivery to specific tissues or specific cell types within tissues.
Fig. 1 Uptake routes of oligonucleotides conjugates. (Winkler, 2013)
|Peptide-Oligonucleotide Conjugation||Peptide-oligonucleotide conjugates (POCs) consist of one or more residues of a linear or less commonly cyclic peptide linked by covalent bonds to an oligonucleotide or its analog.||Inquiry|
|Antibody-Oligonucleotide Conjugation||Antibody-oligonucleotide conjugates (AOC) refer to the use of antibodies to deliver therapeutic oligonucleotides to specific cells or tissues, thereby reducing the amount of drug required to treat a patient's disease as well as solving the problem of untargetable and oligonucleotide delivery.||Inquiry|
|GalNAc-Oligonucleotide Conjugation||Conjugating GalNAc to oligonucleotides (siRNA, ASO, microRNA) to form GalNAc-oligonucleotide conjugates can achieve specific delivery of oligonucleotide drugs to the liver.||Inquiry|
|Protein-Oligonucleotide Conjugation||Conjugating proteins and oligonucleotides improve both the stability and the biological activity of the oligonucleotides.||Inquiry|
|Lipids-Oligonucleotide Conjugation||Lipid-oligonucleotide conjugates (LONs) have become an important topic for improving the safe delivery of oligonucleotides (ASO and siRNAs).||Inquiry|
|Enzyme-Oligonucleotide Conjugation||The direct conjugation of enzymes to oligonucleotides provides the best overall performance with the highest sensitivity, specificity, simplicity and rapid detection.||Inquiry|
|Metal Chelates-Oligonucleotide Conjugation||Metal chelates-oligonucleotide conjugation can be applied in radioimmunoassay (RIA), radioimmunotherapy (RIT), magnetic resonance imaging (MRI), etc.||Inquiry|