Phosphoramidites - RNA / BOC Sciences

Boc-PNA-D(tetraZ)-OH

Description: Boc-PNA-D(tetraZ)-OH is a peptide nucleic acid (PNA) monomer used in the synthesis of PNA oligomers. It features a Boc (tert-butoxycarbonyl) protecting group on the terminal amine and tetraZ (tetra benzyloxycarbonyl) protecting groups on the modified base D. These protecting groups are utilized to protect reactive sites during the solid-phase synthesis, ensuring accurate assembly of PNA sequences. This monomer is important for constructing PNAs with specific binding properties and enhanced stability for various biochemical and biomedical applications.

CAT: BRP-02063

MF: C48H48N8O13

MF: 944.96

Purity: ≥95%

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InChIKey: XREWKMOLHCLRJZ-UHFFFAOYSA-N

CanonicalSMILES: O=C(O)CN(CCNC(OC(C)(C)C)=O)C(CN1C=NC2=C1N=C(N(C(OCC3=CC=CC=C3)=O)C(OCC4=CC=CC=C4)=O)N=C2N(C(OCC5=CC=CC=C5)=O)C(OCC6=CC=CC=C6)=O)=O

IUPAC Name: N-(2-(2,6-bis(bis((benzyloxy)carbonyl)amino)-9H-purin-9-yl)acetyl)-N-(2-((tert-butoxycarbonyl)amino)ethyl)glycine

InChI: InChI=1S/C48H48N8O13/c1-48(2,3)69-43(60)49-24-25-53(27-38(58)59)37(57)26-54-32-50-39-40(54)51-42(56(46(63)67-30-35-20-12-6-13-21-35)47(64)68-31-36-22-14-7-15-23-36)52-41(39)55(44(61)65-28-33-16-8-4-9-17-33)45(62)66-29-34-18-10-5-11-19-34/h4-23,32H,24-31H2,1-3H3,(H,49,60)(H,58,59)

ENA-T-Phosphoramidite

Description: ENA-T-Phosphoramidite is a specialized reagent used in oligonucleotide synthesis. This phosphoramidite derivative allows for the introduction of modified nucleotide sequences into synthetic oligonucleotides, facilitating various research and biotechnological applications.

CAT: BRP-02064

CAS: 287737-40-0

MF: C42H51N4O9P

MF: 786.86

Purity: ≥95%

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InChIKey: BCXPUDBJUMTTSQ-RWDMRMDHSA-N

CanonicalSMILES: CC1=CN(C(=O)NC1=O)C2C3C(C(O2)(CCO3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: 3-[[(1R,5R,7R,8S)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-7-(5-methyl-2,4-dioxopyrimidin-1-yl)-2,6-dioxabicyclo[3.2.1]octan-8-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C42H51N4O9P/c1-28(2)46(29(3)4)56(53-24-11-23-43)55-37-36-39(45-26-30(5)38(47)44-40(45)48)54-41(37,22-25-51-36)27-52-42(31-12-9-8-10-13-31,32-14-18-34(49-6)19-15-32)33-16-20-35(50-7)21-17-33/h8-10,12-21,26,28-29,36-37,39H,11,22,24-25,27H2,1-7H3,(H,44,47,48)/t36-,37+,39-,41-,56?/m1/s1

Synonyms: ENA-T-CE-Phosphoramidite; 2,4(1H,3H)-Pyrimidinedione, 1-[2,6-anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-5-deoxy-α-L-lyxo-hexofuranosyl]-5-methyl-; 1-[2,6-Anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-5-deoxy-α-L-lyxo-hexofuranosyl]-5-methyl-2,4(1H,3H)-pyrimidinedione; ENA-5-Me-U-Phosphoramidite

5'-O-DMT-2'-O-TBDMS-5-Methy-L-Uridine 3'-CE phosphoramidite

Description: 5'-O-DMT-2'-O-TBDMS-5-Methyl-L-Uridine 3'-CE phosphoramidite is a specialized phosphoramidite used in the synthesis of oligonucleotides. It contains a dimethoxytrityl (DMT) group at the 5'-hydroxyl position, a tert-butyldimethylsilyl (TBDMS) group at the 2'-hydroxyl position, and a cyanoethyl (CE) group attached to the phosphoramidite. This reagent incorporates the 5-methyl modification on the uridine base, specifically in the L-configuration, into oligonucleotides, which is important for enhancing the stability and binding properties of the synthesized strands, making it useful in various genetic and therapeutic applications.

CAT: BRP-02151

MF: C46H63N4O9PSi

MF: 875.09

Purity: ≥95%

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InChIKey: KYRSLFQMFXXGLW-PKLCMXGVSA-N

CanonicalSMILES: CC1=CN(C(=O)NC1=O)C2C(C(C(O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OP(N(C(C)C)C(C)C)OCCC#N)O[Si](C)(C)C(C)(C)C

IUPAC Name: 3-[[(2S,3S,4S,5S)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C46H63N4O9PSi/c1-31(2)50(32(3)4)60(56-28-16-27-47)58-40-39(57-43(41(40)59-61(11,12)45(6,7)8)49-29-33(5)42(51)48-44(49)52)30-55-46(34-17-14-13-15-18-34,35-19-23-37(53-9)24-20-35)36-21-25-38(54-10)26-22-36/h13-15,17-26,29,31-32,39-41,43H,16,28,30H2,1-12H3,(H,48,51,52)/t39-,40-,41-,43-,60?/m0/s1

Synonyms: L-Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-5-methyl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; 5-Methyl-5'-O-(4,4'-Dimethoxytrityl)-2'-O-(t-butyldimethylsilyl)-L-uridine-3'-cyanoethyl phosphoramidite; 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-2'-O-[dimethyl(2-methyl-2-propanyl)silyl]-5-methyl-L-uridine; DMT-2'-O-TBDMS-5-Me-L-rU Phosphoramidite; 5'-O-DMT-2'-O-TBDMS-L-rT Phosphoramidite; 5'-O-DMT-2'-O-TBDMS-L-MeU 3'-CE-Phosphoramidite; 2'-O-tert-Butyldimethylsilyl-5'-O-DMT-L-5-methyluridine 3'-CE phosphoramidite; 5'-O-DMTr-2'-O-TBDMS-β-L-T-3'-CE-Phosphoramidite

5'-O-DMT-N4-Acetyl-2'-fluoro-2'-deoxy-L-cytidine 3'-CE phosphoramidite

Description: 5'-O-DMT-N4-Acetyl-2'-fluoro-2'-deoxy-L-cytidine 3'-CE phosphoramidite is a modified phosphoramidite designed for efficient and controlled synthesis of RNA and DNA oligonucleotides. The protective groups and modifications, such as 5'-O-DMTr, N4-acetyl, and 2'-fluoro-2'-deoxy, enhance the stability of the resulting nucleic acids and facilitate their incorporation into nucleic acid chains during solid-phase synthesis. This compound is crucial in the production of antisense oligonucleotides, siRNA, probes, and primers, providing enhanced resistance to enzymatic degradation and improved performance in various applications.

CAT: BRP-02152

CAS: 856888-81-8

MF: C41H49FN5O8P

MF: 789.83

Purity: ≥95%

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InChIKey: CNFKJHKDSRXNFL-NYKPPYOCSA-N

CanonicalSMILES: N#CCCOP(OC1C(F)C(OC1COC(C=2C=CC=CC2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)N5C=CC(=NC5=O)NC(=O)C)N(C(C)C)C(C)C

IUPAC Name: N-[1-[(2S,3S,4S,5S)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-fluorooxolan-2-yl]-2-oxopyrimidin-4-yl]acetamide

InChI: InChI=1S/C41H49FN5O8P/c1-27(2)47(28(3)4)56(53-25-11-23-43)55-38-35(54-39(37(38)42)46-24-22-36(44-29(5)48)45-40(46)49)26-52-41(30-12-9-8-10-13-30,31-14-18-33(50-6)19-15-31)32-16-20-34(51-7)21-17-32/h8-10,12-22,24,27-28,35,37-39H,11,25-26H2,1-7H3,(H,44,45,48,49)/t35-,37-,38-,39-,56?/m0/s1

Synonyms: N-[1-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-deoxy-2-fluoro-β-L-ribofuranosyl]-1,2-dihydro-2-oxo-4-pyrimidinyl]acetamide; (2S,3S,4S,5S)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; N4-Acetyl-2'-deoxy-5'-O-DMT-2'-fluoro-L-cytidine 3'-CE phosphoramidite; 2'-F-Ac-L-dC CE phosphoramide; DMT-2'-F-L-dC(Ac)-CE Phosphoramidite; N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxy-L-cytidine-3'-CE-Phosphoramidite; 2'-Fluoro-2'-deoxy-L-Cytidine (n-ac) CED Phosphoramidite; 5'-O-DMT-2'-F-L-dC(Ac) 3'-CE phosphoramidite

5'-O-DMT-N4-Benzoyl-2'-deoxy-2'-fluoro-cytidine phosphoramidite (BRP-02161)

Description: A novel nucleoside phosphoramidite with anticancer and antiviral properties.

CAT: BRP-02161

CAS: 161442-19-9

MF: C46H51FN5O8P

MF: 851.90

Purity: ≥98% by HPLC

Appearance: White to light yellow solid

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InChIKey: CKKJPMGSTGVCJJ-GNUWXFRUSA-N

Solubility: Soluble in DMSO

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1F)N2C=CC(=NC2=O)NC(=O)C3=CC=CC=C3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-fluorooxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide

InChI: InChI=1S/C46H51FN5O8P/c1-31(2)52(32(3)4)61(58-29-13-27-48)60-42-39(59-44(41(42)47)51-28-26-40(50-45(51)54)49-43(53)33-14-9-7-10-15-33)30-57-46(34-16-11-8-12-17-34,35-18-22-37(55-5)23-19-35)36-20-24-38(56-6)25-21-36/h7-12,14-26,28,31-32,39,41-42,44H,13,29-30H2,1-6H3,(H,49,50,53,54)/t39-,41-,42-,44-,61?/m1/s1

Synonyms: 2'-Fluoro-N4-benzoyl-5'-O-DMT-2'-deoxycytidine-3'-ce-phosphoramidite; Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; 2'-F-Bz-dC Phosphoramidite; N4-Benzoyl-2'-deoxy-5'-O-DMT-2'-fluoro-cytidine phosphoramidite; N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluorocytidine 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

N4-Benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-cytidine 3'-CE phosphoramidite (BRP-02162)

Description: N4-Benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-cytidine 3'-CE phosphoramidite is an indispensable biomolecule, finding profound applications within the intricate synthesis of bespoke nucleotides, thus aiding in genetic investigations.

CAT: BRP-02162

CAS: 118380-84-0

MF: C52H66N5O9PSi

MF: 964.19

Appearance: White to off-white solid

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Storage: Store at 2-8 °C

InChIKey: VWNXEDLLHIFAOL-YOVDOAOFSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=CC(=NC2=O)NC(=O)C3=CC=CC=C3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide

InChI: InChI=1S/C52H66N5O9PSi/c1-36(2)57(37(3)4)67(63-34-18-32-53)65-46-44(35-62-52(39-21-16-13-17-22-39,40-23-27-42(60-8)28-24-40)41-25-29-43(61-9)30-26-41)64-49(47(46)66-68(10,11)51(5,6)7)56-33-31-45(55-50(56)59)54-48(58)38-19-14-12-15-20-38/h12-17,19-31,33,36-37,44,46-47,49H,18,34-35H2,1-11H3,(H,54,55,58,59)/t44-,46-,47-,49-,67?/m1/s1

Synonyms: Bz-rC Phosphoramidite; N-Bz-2'-O-TBDMS-5'-DMT-cytidine 3'-CE phosphoramidite; Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-[2-cyanoethylbis(1-methylethyl)phosphoramidite]; N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-tert-butyldimethylsilyl)cytidine 3'-O-[O-(2-cyanoethyl)-N,N'-diisopropylphosphoramidite]; 5'-DMT-2'-TBDMS-N4-Bz-rC phosphoramidite; 5'-O-DMT-2'-O-TBDMS-rC (Bz) phosphoramidite; 5'-O-DMT-2'-O-TBDMS-rC(Bz) 3'-CE phosphoramidite

2'-O-Methyl-rG(N-Ac) phosphoramidite (BRP-02166)

Description: 2'-O-Methyl-rG(N-Ac) phosphoramidite is an anticancer agent with antiviral and antiparasitic activities. 2'-O-Methyl-rG(N-Ac) phosphoramidite is a modified guanosine phosphoramidite used in oligonucleotide synthesis. It features a 2'-O-methyl group, which enhances the stability of the oligonucleotide by increasing resistance to nucleases and improving binding affinity. The N-Ac (N-acetyl) group protects the amino group of the guanine base during synthesis. This reagent is particularly useful for synthesizing RNA molecules with increased stability and improved hybridization properties, making it valuable for applications in molecular biology, diagnostics, and therapeutic development.

CAT: BRP-02166

CAS: 909033-40-5

MF: C43H52N7O9P

MF: 841.89

Purity: ≥98%

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InChIKey: FBABQKPBRXEHBT-USUFPPIWSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OC)N2C=NC3=C2N=C(NC3=O)NC(=O)C)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-methoxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]acetamide

InChI: InChI=1S/C43H52N7O9P/c1-27(2)50(28(3)4)60(57-24-12-23-44)59-37-35(58-41(38(37)55-8)49-26-45-36-39(49)47-42(46-29(5)51)48-40(36)52)25-56-43(30-13-10-9-11-14-30,31-15-19-33(53-6)20-16-31)32-17-21-34(54-7)22-18-32/h9-11,13-22,26-28,35,37-38,41H,12,24-25H2,1-8H3,(H2,46,47,48,51,52)/t35-,37-,38-,41-,60?/m1/s1

Synonyms: Ac-2'-OMe-rG Phosphoramidite; N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-methylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite; 5'-O-DMT-2'-O-Me-rG(Ac)-3'-CE phosphoramidite; 5'-O-DMT-2'-O-Me-rG(N-Ac)-3'-CED; 5'-DMT-2'-OMe-rG(N-Ac) Phosphoramidite; Guanosine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

1-(2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)uracil 3'-CE-phosphoramidite (BRP-02167)

Description: 1-(2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)uracil 3'-CE-phosphoramidite is a novel nucleotide monophosphate with antiviral and anticancer properties.

CAT: BRP-02167

CAS: 1190089-70-3

MF: C39H46FN4O8P

MF: 748.78

Purity: ≥95%

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InChIKey: HQHQPAYRJJMYQX-CPBIVIIKSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1F)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: 3-[[(2R,3R,4S,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(2,4-dioxopyrimidin-1-yl)-4-fluorooxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C39H46FN4O8P/c1-26(2)44(27(3)4)53(50-24-10-22-41)52-36-33(51-37(35(36)40)43-23-21-34(45)42-38(43)46)25-49-39(28-11-8-7-9-12-28,29-13-17-31(47-5)18-14-29)30-15-19-32(48-6)20-16-30/h7-9,11-21,23,26-27,33,35-37H,10,24-25H2,1-6H3,(H,42,45,46)/t33-,35+,36-,37-,53?/m1/s1

Synonyms: 2'-Fluoro-2'-deoxy-ara-U-3'-phosphoramidite; 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxy-2'-fluoro-b-D-arabinouridine-3'-CEN-phosphoramidite; 5'-O-DMT-2'-F-2'-arabinofuranosyl-deoxyuridine 3'-CE phosphoramidite; 2,4(1H,3H)-Pyrimidinedione, 1-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-deoxy-2-fluoro-α-D-arabinofuranosyl]-; 2'-ara-2'-F-2'-dU Phosphoramidite; 2'-F-U-ANA-CE Phosphoramidite

5'-O-DMT-3'-O-tert-Butyldimethylsilyl-uridine-2'-CE phosphoramidite (BRP-02169)

Description: 5'-O-DMT-3'-O-tert-Butyldimethylsilyl-uridine-2'-CE phosphoramidite is a phosphoramidite reagent used in the synthesis of oligonucleotides. It features a dimethoxytrityl (DMT) protecting group at the 5'-hydroxyl position, a tert-butyldimethylsilyl (TBDMS) protecting group at the 3'-hydroxyl position, and a cyanoethyl (CE) protecting group on the phosphoramidite at the 2' position. These protective groups ensure efficient incorporation of uridine into oligonucleotides while enhancing the stability and accuracy of synthesis. This reagent is important for creating modified oligonucleotides for research and therapeutic applications.

CAT: BRP-02169

CAS: 129451-77-0

MF: C45H61N4O9PSi

MF: 861.05

Purity: ≥97% by HPLC

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InChIKey: UZVSHRLVIXPYEZ-ZMHKPELYSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(C(OC1N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)O[Si](C)(C)C(C)(C)C

IUPAC Name: 3-[[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-2-(2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C45H61N4O9PSi/c1-31(2)49(32(3)4)59(55-29-15-27-46)57-41-40(58-60(10,11)44(5,6)7)38(56-42(41)48-28-26-39(50)47-43(48)51)30-54-45(33-16-13-12-14-17-33,34-18-22-36(52-8)23-19-34)35-20-24-37(53-9)25-21-35/h12-14,16-26,28,31-32,38,40-42H,15,29-30H2,1-11H3,(H,47,50,51)/t38-,40-,41-,42-,59?/m1/s1

Synonyms: 3'-O-tert-Butyldimethylsilyl-5'-O-DMT-uridine 2'-CE phosphoramidite; 3'-TBDMS-rU Phosphoramidite; 5-O-(4,4'-dimethoxytrityl)-2-O-(diisopropylamino-2-cyanoethoxyphosphanyl)-3-O-(tert-butyl-dimethyl-silyl)-1-deoxy-1-uracil-1-yl-beta-D-ribo-pentofuranose; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 2'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; 3'-OTBS U 2'-amidite; 3'-O-TBDMS-5'-O-DMT-rU CED phosphoramidite; DMT-3'-O-TBDMS-U-2'-CE-Phosphoramidite

2'-Fluoro-2'-deoxy-ara-C(Bz)-3'-phosphoramidite (BRP-02171)

Description: 2'-Fluoro-2'-deoxy-ara-C(Bz)-3'-phosphoramidite is a modified phosphoramidite used in the synthesis of oligonucleotides. This compound features a 2'-fluoro and 2'-deoxy modification on the arabinose sugar, a benzoyl (Bz) protective group on the nucleobase cytosine, and a phosphoramidite group at the 3' position. These modifications enhance the chemical stability and binding affinity of the resulting oligonucleotides, making them useful for applications in molecular biology, diagnostics, and therapeutic development.

CAT: BRP-02171

CAS: 1404463-12-2

MF: C46H51FN5O8P

MF: 851.90

Purity: ≥95%

Appearance: White to Off-white Powder

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Storage: Store at -20 °C

Boiling Point: 856.5±75.0°C at 760 mmHg

InChIKey: CKKJPMGSTGVCJJ-OEJVQKCDSA-N

Solubility: Soluble in DMSO

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1F)N2C=CC(=NC2=O)NC(=O)C3=CC=CC=C3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: N-[1-[(2R,3S,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-fluorooxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide

Synonyms: N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-fluoro-b-D-arabinocytidine-3'-CED-phosphoramidite; N4-Benzoyl-2'-fluoro-5'-O-DMT-2'-arabinofuranosyl-deoxycytidine phosphoramidite; 4-(Benzoylimino)-1-{5-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-2-deoxy-2-fluoro-β-D-arabinofuranosyl}-1,4-dihydro-2-pyrimidinol; N4-Benzoyl-1-(2'-deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)cytidine 3'-CE-phosphoramidite; 5'-O-DMTr-2'-ara-F-C(Bz)-3'-CE-Phosphoramidite; 2'-F-2'-ara-Bz-dC Phosphoramidite; 2'-F-dC(Bz)-ANA-CE Phosphoramidite; 2'-F-2'-ara-N4-Bz-dC phosphoramidite

9-(2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)-N2-isobutyrylguanine 3'-CE phosphoramidite (BRP-02172)

Description: The 9-(2'-Deoxy-5'-O-DMT-2'-fluoro-beta-D-arabinofuranosyl)-N2-isobutyrylguanine 3'-CE phosphoramidite has been proven effective against cancer.

CAT: BRP-02172

CAS: 1404463-20-2

MF: C44H53FN7O8P

MF: 857.93

Purity: ≥97% by HPLC

Appearance: White to Off-white Solid

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InChIKey: KJFUMXZZVYMQEU-SJIRJWTBSA-N

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N(C(C)C)C(C)C)OCCC#N)F

IUPAC Name: N-[9-[(2R,3S,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-fluorooxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide

InChI: InChI=1S/C44H53FN7O8P/c1-27(2)40(53)49-43-48-39-37(41(54)50-43)47-26-51(39)42-36(45)38(60-61(58-24-12-23-46)52(28(3)4)29(5)6)35(59-42)25-57-44(30-13-10-9-11-14-30,31-15-19-33(55-7)20-16-31)32-17-21-34(56-8)22-18-32/h9-11,13-22,26-29,35-36,38,42H,12,24-25H2,1-8H3,(H2,48,49,50,53,54)/t35-,36+,38-,42-,61?/m1/s1

Synonyms: 5'-O-DMT-2'-fluoro-N2-isobutyryl-2'-arabinofuranosyl-deoxyguanosine 3'-CE phosphoramidite; 2'-F-2'-ara-N2-ibu-dG phosphoramidite; Propanamide, N-[9-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-deoxy-2-fluoro-β-D-arabinofuranosyl]-6,9-dihydro-6-oxo-1H-purin-2-yl]-2-methyl-; N2-iso-Butyroyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-fluoro-2'-arabinoguanosine-3'-CED-phosphoramidite; 9-{5-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-3-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-2-deoxy-2-fluoro-β-D-arabinofuranosyl}-2-(isobutyrylamino)-1,9-dihydro-6H-purin-6-one

5'-O-DMT-3'-O-tert-Butyldimethylsilyl-N2-isobutyrylguanosine 2'-CE phosphoramidite (BRP-02175)

Description: 5'-O-DMT-3'-O-tert-Butyldimethylsilyl-N2-isobutyrylguanosine 2'-CE phosphoramidite is a specialized phosphoramidite used for the synthesis of oligonucleotides. It includes a 5'-dimethoxytrityl (DMT) group for 5'-hydroxyl protection, a 3'-tert-butyldimethylsilyl (TBDMS) group for 3'-hydroxyl protection, and an N2-isobutyryl group to protect the exocyclic amine of the guanine base. Additionally, it has a cyanoethyl (CE) group at the 2'-position of the phosphoramidite. These protective groups help facilitate efficient synthesis and stability of the oligonucleotides, making this compound valuable for research, diagnostic, and therapeutic applications.

CAT: BRP-02175

CAS: 1445905-51-0

MF: C50H68N7O9PSi

MF: 970.18

Purity: ≥95%

Appearance: White, off-white to faint yellow powder

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InChIKey: JCCWPNDXSMAHGZ-FTZVBZPOSA-N

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)O[Si](C)(C)C(C)(C)C)OP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-3-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide

InChI: InChI=1S/C50H68N7O9PSi/c1-32(2)45(58)54-48-53-44-41(46(59)55-48)52-31-56(44)47-43(65-67(63-29-17-28-51)57(33(3)4)34(5)6)42(66-68(12,13)49(7,8)9)40(64-47)30-62-50(35-18-15-14-16-19-35,36-20-24-38(60-10)25-21-36)37-22-26-39(61-11)27-23-37/h14-16,18-27,31-34,40,42-43,47H,17,29-30H2,1-13H3,(H2,53,54,55,58,59)/t40-,42-,43-,47-,67?/m1/s1

Synonyms: 3'-O-tert-Butyldimethylsilyl-5'-O-DMT-N2-isobutyrylguanosine 2'-CE phosphoramidite; (2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-2-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; 3'-TBDMS-ibu-rG Phosphoramidite; 3'-O-TBDMS-5'-O-DMT-N2-iBu-rG CED phosphoramidite; 5'-O-DMTr-2'-O-TBDMS-L-G(iBu)-3'-CE-Phosphoramidite; N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyl-dimethylsilyl)-L-guanosine-3'-cyanoethyl Phosphoramidite

5'-O-DMT-2'-O-TBDMS-5-Methy-Uridine 3'-CE phosphoramidite (BRP-02176)

Description: 5'-O-DMT-2'-O-TBDMS-5-Methyl-Uridine 3'-CE phosphoramidite is a modified phosphoramidite reagent used in oligonucleotide synthesis. This compound features protective groups: a dimethoxytrityl (DMT) group at the 5'-hydroxyl position, a tert-butyldimethylsilyl (TBDMS) group at the 2'-hydroxyl position, and a cyanoethyl (CE) protecting group on the phosphoramidite moiety. These modifications allow for the efficient incorporation of 5-methyluridine into synthetic oligonucleotides, enhancing their stability and binding affinity, which is crucial for applications in genetic research and therapeutic development.

CAT: BRP-02176

CAS: 159639-78-8

MF: C46H63N4O9PSi

MF: 875.09

Purity: ≥98% by HPLC

Appearance: White powder

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InChIKey: KYRSLFQMFXXGLW-IEXCOMMKSA-N

CanonicalSMILES: CC1=CN(C(=O)NC1=O)C2C(C(C(O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OP(N(C(C)C)C(C)C)OCCC#N)O[Si](C)(C)C(C)(C)C

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

Synonyms: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-5-methyl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; 5-Methyl-5'-O-(4,4'-Dimethoxytrityl)-2'-O-(t-butyldimethylsilyl)-uridine-3'-cyanoethyl phosphoramidite; 5-O-(4,4'-dimethoxytrityl)-3-O-(diisopropylamino-2-cyanoethoxyphosphanyl)-2-O-(tert-butyl-dimethyl-silyl)-1-deoxy-1-thymin-1-yl-beta-D-ribo-pentofuranose; 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-2'-O-[dimethyl(2-methyl-2-propanyl)silyl]-5-methyluridine; DMT-2'-O-TBDMS-5-Me-rU Phosphoramidite; 5'-O-DMT-2'-O-TBDMS-rT Phosphoramidite; 5'-O-DMTr-2'-O-TBDMS-5-Me-U-3'-CE-Phosphoramidite; 2'-OTBS T amidite; 2'-O-tert-Butyldimethylsilyl-5'-O-DMT-5-methyluridine 3'-CE phosphoramidite; 5-Me-U-CE Phosphoramidite

N4-Bz-5'-O-DMTr-2'-O-Me-cytidine-3'-CED-phosphoramidite (BRP-02177)

Description: N4-Bz-5'-O-DMTr-2'-O-Me-cytidine-3'-CED-phosphoramidite is a modified phosphoramidite designed for use in the synthesis of stable and efficient oligonucleotides. Its protective groups and modifications enhance the stability of the resulting nucleic acids and facilitate their incorporation into nucleic acid chains during solid-phase synthesis. This compound is crucial in the production of antisense oligonucleotides, siRNA, probes, and primers, providing enhanced resistance to enzymatic degradation and improved performance in various applications.

CAT: BRP-02177

CAS: 110764-78-8

MF: C47H54N5O9P

MF: 863.93

Purity: ≥95%

Appearance: White Powder

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InChIKey: JFFSFQRVIPPCBC-VKBHKTMGSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OC)N2C=CC(=NC2=O)NC(=O)C3=CC=CC=C3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-methoxyoxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide

InChI: InChI=1S/C47H54N5O9P/c1-32(2)52(33(3)4)62(59-30-14-28-48)61-42-40(60-45(43(42)57-7)51-29-27-41(50-46(51)54)49-44(53)34-15-10-8-11-16-34)31-58-47(35-17-12-9-13-18-35,36-19-23-38(55-5)24-20-36)37-21-25-39(56-6)26-22-37/h8-13,15-27,29,32-33,40,42-43,45H,14,30-31H2,1-7H3,(H,49,50,53,54)/t40-,42-,43-,45-,62?/m1/s1

Synonyms: N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methycytidine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite; 2'-O-Me-C(Bz)-3'-phosphoramidite; 2'-OMe-Bz-C Phosphoramidite; N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methylcytidine 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; N-Benzoyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-2'-O-methylcytidine; N4-Benzoyl-5'-O-DMT-2'-O-methylcytidine 3'-CE phosphoramidite

5'-O-DMT-2'-O-(2-methoxyethyl)uridine 3'-CE phosphoramidite (BRP-02178)

Description: 5'-O-DMT-2'-O-(2-methoxyethyl)uridine 3'-CE phosphoramidite is a building block for introducing uridine units into oligonucleotides.

CAT: BRP-02178

CAS: 163759-97-5

MF: C42H53N4O10P

MF: 804.86

Purity: ≥95%

Appearance: White to Off-white Powder

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InChIKey: ZLOKLUONKGURQI-UAQIPLLRSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OCCOC)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(2,4-dioxopyrimidin-1-yl)-4-(2-methoxyethoxy)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C42H53N4O10P/c1-29(2)46(30(3)4)57(54-25-11-23-43)56-38-36(55-40(39(38)52-27-26-49-5)45-24-22-37(47)44-41(45)48)28-53-42(31-12-9-8-10-13-31,32-14-18-34(50-6)19-15-32)33-16-20-35(51-7)21-17-33/h8-10,12-22,24,29-30,36,38-40H,11,25-28H2,1-7H3,(H,44,47,48)/t36-,38-,39-,40-,57?/m1/s1

Synonyms: 2'-O-MOE-U-3'-phosphoramidite; 5'-O-DMTr-2'-O-(2-methoxyethyl)-uridine-3'-CED-phosphoramidite; 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)uridine 3'-[2-cyanoethylbis(1-methylethyl)phosphoramidite]; 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-2'-O-(2-methoxyethyl)uridine

5'-O-DMT-2'-O-tert-Butyldimethylsilyl-N6-methyl-adenosine 3'-CE phosphoramidite (BRP-02185)

Description: 5'-O-DMT-2'-O-tert-Butyldimethylsilyl-N6-methyl-adenosine 3'-CE phosphoramidite is a vital compound used in the biomedical industry for synthesizing RNA molecules. This phosphoramidite aids in the incorporation of modified adenosine bases during RNA synthesis, enabling researchers to study specific drug targets or diseases related to N6-methyladenosine methylation. By providing precise adenosine modifications, this product facilitates the investigation of gene expression and regulatory mechanisms, leading to potential breakthroughs in drug discovery and disease understanding.

CAT: BRP-02185

CAS: 588698-79-7

MF: C47H64N7O7PSi

MF: 898.11

Purity: ≥98% by HPLC

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Boiling Point: 859.0±75.0°C (Predicted)

InChIKey: GPLFLRPEMRRWIR-UTZPQXNGSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=NC3=C(N=CN=C32)NC)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-5-[6-(methylamino)purin-9-yl]oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C47H64N7O7PSi/c1-32(2)54(33(3)4)62(58-28-16-27-48)60-41-39(59-45(42(41)61-63(11,12)46(5,6)7)53-31-52-40-43(49-8)50-30-51-44(40)53)29-57-47(34-17-14-13-15-18-34,35-19-23-37(55-9)24-20-35)36-21-25-38(56-10)26-22-36/h13-15,17-26,30-33,39,41-42,45H,16,28-29H2,1-12H3,(H,49,50,51)/t39-,41-,42-,45-,62?/m1/s1

Synonyms: Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-N-methyl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; N6-Me-rA phosphoramidite; 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-2'-O-[dimethyl(2-methyl-2-propanyl)silyl]-N-methyladenosine; N6-Me-DMT-2'-O-TBDMS-A-CE Phosphoramidite; N6-Methyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyl-dimethylsilyl)-adenosine-3'-cyanoethyl-Phosphoramidite; 5'-O-DMT-2'-O-TBDMS-N6-methyl-Adenosine 3'-CE phosphoramidite; DMTr-2'-O-TBDMS-N6-Me-rA-3'-CE-Phosphoramidite

N2-Acetyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-guanosine 3'-CE phosphoramidite (BRP-02187)

Description: Commonly used protected 2-OTBDMS phosphoramidite for incorporation of nucleotide-G into the synthesis of oligonucleotides.

CAT: BRP-02187

CAS: 944138-03-8

MF: C48H64N7O9PSi

MF: 942.12

Purity: ≥98%

Appearance: White, off-white to yellow powder

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InChIKey: DGDYJRDKFZTURB-WUYIOLTESA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=NC3=C2N=C(NC3=O)NC(=O)C)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]acetamide

InChI: InChI=1S/C48H64N7O9PSi/c1-31(2)55(32(3)4)65(61-28-16-27-49)63-41-39(29-60-48(34-17-14-13-15-18-34,35-19-23-37(58-9)24-20-35)36-21-25-38(59-10)26-22-36)62-45(42(41)64-66(11,12)47(6,7)8)54-30-50-40-43(54)52-46(51-33(5)56)53-44(40)57/h13-15,17-26,30-32,39,41-42,45H,16,28-29H2,1-12H3,(H2,51,52,53,56,57)/t39-,41-,42-,45-,65-/m1/s1

Synonyms: Ac-G-CE Phosphoramidite; 5'-O-DMTr-2'-O-TBDMS-G(Ac)-3'-CE-Phosphoramidite; N2-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyl-dimethylsilyl)-guanine-3'-cyanoethyl Phosphoramidite; 2'-O-[(tert-Butyl)dimethylsilyl]-N-acetylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite; 5'-DMT-2'-TBDMS-rG(N-Ac) Phosphoramidite; N-Acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]guanosine 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; 2'-TBDMS-G CEP; DMT-2'-O-TBDMS-G(Ac) 3'-CE-Phosphoramidite

5'-O-DMT-2'-O-TBDMS-N2-ibu-2-aminoadenosine 3'-CE phosphoramidite (BRP-02188)

Description: 5'-O-DMT-2'-O-TBDMS-N2-ibu-2-aminoadenosine 3'-CE phosphoramidite is a compound assuming a pivotal role in oligonucleotide modification. Employed extensively in diverse applications such as targeted drug delivery systems, this phosphoramidite plays a pioneering role in the quest for refined therapeutics that combat distinctive ailments like cancer and genetic anomalies.

CAT: BRP-02188

MF: C50H69N8O8PSi

MF: 969.21

Purity: ≥97% by HPLC

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InChIKey: NKCWJSASWRVTLE-FTZVBZPOSA-N

IUPAC Name: (2R,3R,4R,5R)-5-(6-amino-2-isobutyramido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C50H69N8O8PSi/c1-32(2)46(59)56-48-54-44(52)41-45(55-48)57(31-53-41)47-43(66-68(12,13)49(7,8)9)42(65-67(63-29-17-28-51)58(33(3)4)34(5)6)40(64-47)30-62-50(35-18-15-14-16-19-35,36-20-24-38(60-10)25-21-36)37-22-26-39(61-11)27-23-37/h14-16,18-27,31-34,40,42-43,47H,17,29-30H2,1-13H3,(H3,52,54,55,56,59)/t40-,42-,43-,47-,67?/m1/s1

Synonyms: DMT-2'-O-TBDMS-N2-iBu-2-aminoadenosine phosphoramidite; DMT-2'-O-TBDMS-N2-iBu-A-CE-Phosphoramidite; 5'-O-DMTr-2'-O-TBDMS-N2-iBu-A-3'-CE-Phosphoramidite; 5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]-N2-isobutyryladenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

5'-O-DMT-2'-O-tert-Butyldimethylsilyl-N6-Benzoyl-8-Iodoadenosine 3'-CE phosphoramidite (BRP-02189)

Description: 5'-O-DMT-2'-O-tert-Butyldimethylsilyl-N6-Benzoyl-8-Iodoadenosine 3'-CE phosphoramidite, a critical and indispensable reagent in the highly esteemed biomedical industry, manifests its profound significance in the realm of modified nucleic acids synthesis. Its exceptional utility primarily lies in its adeptness for effectuating the introduction of the esteemed 5'-O-DMT-2'-O-tert-Butyldimethylsilyl-N6-Benzoyl-8-Iodoadenosine moiety during phosphoramidite-mediated DNA synthesis. This unparalleled product unveils a wealth of opportunities within the sphere of nucleic acid-based therapeutic development, acting as a fulcrum for groundbreaking research directed towards unravelling the complexities of diverse disease entities and optimizing drug targeting strategies.

CAT: BRP-02189

MF: C53H65IN7O8PSi

MF: 1114.11

Purity: ≥97% by HPLC

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InChIKey: YIYILOGGUDEHPF-UFCBNZGASA-N

IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-8-iodo-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C53H65IN7O8PSi/c1-35(2)61(36(3)4)70(66-32-18-31-55)68-45-43(33-65-53(38-21-16-13-17-22-38,39-23-27-41(63-8)28-24-39)40-25-29-42(64-9)30-26-40)67-50(46(45)69-71(10,11)52(5,6)7)60-48-44(58-51(60)54)47(56-34-57-48)59-49(62)37-19-14-12-15-20-37/h12-17,19-30,34-36,43,45-46,50H,18,32-33H2,1-11H3,(H,56,57,59,62)/t43-,45-,46-,50-,70?/m1/s1

Synonyms: 8-I-rA phosphoramidite; DMT-2'-O-TBDMS-8-I-A(Bz)-CE-Phosphoramidite; N6-Benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-8-Iodoadenosine 3'-CE phosphoramidite; 5'-O-DMT-2'-O-TBDMS-8-I-A(Bz)-3'-CE-Phosphoramidite

5'-O-DMT-N4-Acetyl-2'-fluoro-2'-arabinofuranosyl-deoxycytidine 3'-CE phosphoramidite (BRP-02190)

Description: 5'-O-DMT-N4-Acetyl-2'-fluoro-2'-arabinofuranosyl-deoxycytidine 3'-CE phosphoramidite is a crucial reagent extensively used in the biomedical industry for the synthesis of nucleosides and nucleotides. This product plays a significant role in the development of therapeutic drugs targeting various diseases, including viral infections and cancer. With its unique properties, it enables researchers to design and fabricate novel nucleoside analogs with potential antiviral and anticancer activities, contributing to advancements in biomedicine.

CAT: BRP-02190

MF: C41H49FN5O8P

MF: 789.83

Purity: ≥97% by HPLC

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InChIKey: CNFKJHKDSRXNFL-AXLBFYELSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1F)N2C=CC(=NC2=O)NC(=O)C)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: N-[1-[(2R,3S,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-fluorooxolan-2-yl]-2-oxopyrimidin-4-yl]acetamide

Synonyms: 2'-F-2'-ara-Ac-dC Phosphoramidite; 4-Acetamido-1-{5-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-2-deoxy-2-fluoro-β-D-arabinofuranosyl}-2(1H)-pyrimidinone; 2(1H)-Pyrimidinone, 4-(acetylamino)-1-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-deoxy-2-fluoro-β-D-arabinofuranosyl]-; N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-deoxy-2'-fluorocytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite