Phosphoramidites

Description: 2'-O-MOE-N6-Me-rA Phosphoramidite is a modified phosphoramidite featuring a 2'-O-methoxyethyl (MOE) group on the ribose sugar and a methyl group on the N6 position of the adenine base. These modifications enhance the stability, nuclease resistance, and binding affinity of the resulting oligonucleotides. The 3'-cyanoethyl (CE) phosphoramidite group enables efficient incorporation into oligonucleotides during automated synthesis. This compound is commonly used in the development of antisense oligonucleotides, siRNA, and other therapeutic nucleic acids, providing improved pharmacokinetic properties and enhanced biological performance in research and therapeutic applications.

CAT: BRP-02390

Molecular Formula: C44H56N7O8P

Molecular Weight: 841.95

Purity: ≥98%

Description: 4-Thio-2'-OMe-rU Phosphoramidite is a modified phosphoramidite where the oxygen atom at the 4-position of the uracil base is replaced with a sulfur atom, and the ribose sugar is functionalized with a 2'-O-methyl (OMe) group. The 3'-cyanoethyl (CE) phosphoramidite group allows its incorporation into oligonucleotides via automated synthesis. This modification enhances the stability of RNA analogs and provides unique chemical properties, such as increased resistance to nuclease degradation and the ability to engage in thiol-specific reactions. It is particularly valuable in therapeutic oligonucleotide development, RNA structure-function studies, and the creation of oligonucleotides with enhanced biological activity.

CAT: BRP-02391

CAS: 1338923-37-7

Molecular Formula: C43H52N5O8PS

Molecular Weight: 829.95

Purity: ≥95%

Description: 4-Thio-2'-MOE-5-Me-rU Phosphoramidite is a modified phosphoramidite where the oxygen atom at the 4-position of the uracil base is replaced with a sulfur atom, the ribose sugar contains a 2'-O-methoxyethyl (MOE) modification, and the uracil base is methylated at the 5-position. The 3'-cyanoethyl (CE) phosphoramidite group enables efficient incorporation into oligonucleotides during automated synthesis. These combined modifications enhance the stability, nuclease resistance, and binding affinity of the oligonucleotides while also introducing thiol-reactive functionality. It is widely used in the design of antisense oligonucleotides, siRNA, and other therapeutic nucleic acids, as well as in biochemical research to study nucleic acid-protein interactions and nucleic acid chemistry.

CAT: BRP-02392

Molecular Formula: C46H58N5O9PS

Molecular Weight: 888.03

Purity: ≥95%

Description: (S)-SNA-C(Ac) Phosphoramidite is a serinol nucleic acid (SNA) analog featuring a cytosine base modified with an acetyl (Ac) group and attached to a serinol-derived backbone with (S)-stereochemistry. This modified backbone replaces the natural ribose, enhancing the stability and nuclease resistance of the resulting oligonucleotides. The 3'-phosphoramidite functionality facilitates its incorporation into oligonucleotides via automated synthesis. These properties make (S)-SNA-C(Ac) Phosphoramidite valuable for developing therapeutic oligonucleotides, including antisense and siRNA, as well as for research applications requiring robust and chemically stable nucleic acid analogs.

CAT: BRP-02393

Molecular Formula: C41H51N6O8P

Molecular Weight: 786.87

Purity: ≥98%

Description: DMTr-2'-O-C22-rC(Ac)-3'-CE-Phosphoramidite is a modified phosphoramidite designed for oligonucleotide synthesis. It features a long-chain aliphatic modification (C22) attached to the 2'-hydroxyl group of the ribose, enhancing hydrophobicity and enabling specialized interactions. The cytosine base is protected with an acetyl (Ac) group to maintain stability during synthesis, while the 5'-hydroxyl group is protected with a dimethoxytrityl (DMTr) group for sequential oligonucleotide assembly. The 3'-cyanoethyl (CE) phosphoramidite group ensures compatibility with automated DNA or RNA synthesis. This modification is used in designing oligonucleotides with unique structural or functional properties, particularly for applications in nanotechnology, therapeutic delivery systems, and biomolecular research.

CAT: BRP-02394

CAS: 2923115-93-7

Molecular Formula: C63H94N5O9P

Molecular Weight: 1096.44

Purity: ≥95%

Description: 2'-ANA-O-TBDMS-A(Bz) Phosphoramidite is a modified phosphoramidite designed for oligonucleotide synthesis. It features an arabinofuranosyl sugar configuration with a 2'-O-tert-butyldimethylsilyl (TBDMS) group for protection during synthesis. The adenine base is protected at the N6 position with a benzoyl (Bz) group, and the 5'-hydroxyl group is protected with a dimethoxytrityl (DMT) group, ensuring controlled sequential addition in automated synthesis. The 3'-cyanoethyl (CE) phosphoramidite group enables its integration into oligonucleotides. This compound is widely used in synthesizing modified oligonucleotides, particularly for applications requiring increased stability or altered hybridization properties, such as antisense therapies, siRNA design, and biochemical research.

CAT: BRP-02395

Molecular Formula: C53H66N7O8PSi

Molecular Weight: 988.21

Purity: ≥95%

Description: 2'-ANA-O-TBDMS-C(Ac) Phosphoramidite is a modified phosphoramidite designed for oligonucleotide synthesis. It features an arabinose (ara) sugar configuration, with a 2'-O-tert-butyldimethylsilyl (TBDMS) protective group to stabilize the nucleoside during the synthesis process. The cytosine base is protected with an acetyl (Ac) group at the exocyclic amine to prevent undesired reactions. The 5'-hydroxyl group is protected by a dimethoxytrityl (DMT) group, allowing for controlled stepwise addition of nucleotides in automated synthesis. The 3'-cyanoethyl (CE) phosphoramidite group enables efficient incorporation into oligonucleotide chains. This modification enhances the stability, nuclease resistance, and hybridization properties of the resulting oligonucleotides, making it useful in the development of RNA-based therapeutics, antisense oligonucleotides, and siRNA.

CAT: BRP-02396

Molecular Formula: C47H64N5O9PSi

Molecular Weight: 902.11

Purity: ≥95%

Description: 2'-ANA-O-TBDMS-G(ibu) Phosphoramidite is a phosphoramidite derivative that includes a modified guanosine nucleoside with specific protective groups. The guanine base is protected with an isobutyryl (ibu) group at the exocyclic amine, and the ribose sugar is modified with an arabinose (2'-ara) configuration. The 2'-OH group is protected with a tert-butyldimethylsilyl (TBS) group, and the 5'-hydroxyl group is protected with a dimethoxytrityl (DMTr) group. The 3'-cyanoethyl (CE) phosphoramidite group facilitates its incorporation into oligonucleotides during automated synthesis. This compound is widely used in oligonucleotide synthesis, offering enhanced stability, resistance to nuclease degradation, and improved hybridization properties for research and therapeutic applications.

CAT: BRP-02397

Molecular Formula: C50H68N7O9PSi

Molecular Weight: 970.19

Purity: ≥95%

Description: 2'-ANA-O-TBDMS-U Phosphoramidite is a modified phosphoramidite designed for use in automated oligonucleotide synthesis. It features an arabinose (ara) sugar configuration, with a 2'-O-tert-butyldimethylsilyl (TBDMS) protecting group to prevent unwanted reactions during synthesis. The 5'-hydroxyl group is protected by a dimethoxytrityl (DMT) group, ensuring controlled stepwise assembly of the oligonucleotide. The 3'-cyanoethyl (CE) phosphoramidite group allows efficient incorporation into the growing oligonucleotide chain. This modification enhances the stability, nuclease resistance, and hybridization properties of the resulting oligonucleotides, making it valuable in the development of RNA-based therapeutics, antisense oligonucleotides, and siRNA.

CAT: BRP-02398

Molecular Formula: C45H61N4O9PSi

Molecular Weight: 861.06

Purity: ≥95%

Description: 2'-O-EOE-5-Me-rU Phosphoramidite is a modified phosphoramidite designed for use in oligonucleotide synthesis. It features a 2'-O-ethoxyethyl (EOE) group on the ribose sugar, which enhances the stability and nuclease resistance of the resulting oligonucleotides. The uracil base is methylated at the 5-position (5-Me), providing additional chemical stability. The 3'-cyanoethyl (CE) phosphoramidite group enables efficient incorporation of this modified nucleoside into oligonucleotide chains during automated synthesis. This modification improves the hybridization properties and stability of the synthesized oligonucleotides, making it suitable for applications in RNA-based therapeutics, antisense oligonucleotides, and other nucleic acid research where increased stability and resistance to degradation are required.

CAT: BRP-02399

Molecular Formula: C44H57N4O10P

Molecular Weight: 832.93

Purity: ≥98%

Appearance: White to off-white powder

Description: 2'-TC-A(Bz) Phosphoramidite is a modified phosphoramidite featuring a TC group and an adenine base protected with a benzoyl (Bz) group at the N6 position. The 2'-thio modification increases the stability and resistance of the resulting oligonucleotides to nucleases, improving their overall chemical stability. The benzoyl protection on the adenine base prevents unwanted reactions during synthesis. The 3'-cyanoethyl (CE) phosphoramidite group allows for efficient incorporation into oligonucleotides during automated synthesis. This modification is useful in creating oligonucleotides with enhanced stability and nuclease resistance, making it suitable for applications in therapeutic nucleic acids, antisense oligonucleotides, and other molecular biology studies.

CAT: BRP-02400

CAS: 1219089-94-7

Molecular Formula: C52H59N8O10PS2

Molecular Weight: 1051.18

Purity: ≥98%

Appearance: White to light yellow to light orange solid

Description: 2'-TC-G(Ibu) Phosphoramidite is a modified phosphoramidite featuring a TC modification on the ribose sugar and a guanine base that is protected with an isobutyryl (Ibu) group at the exocyclic amine. The 2'-thio modification enhances the stability and resistance of the resulting oligonucleotides to nuclease degradation, improving their overall chemical stability. The isobutyryl protection on the guanine base ensures selective incorporation and prevents unwanted side reactions during the synthesis process. The 3'-cyanoethyl (CE) phosphoramidite group facilitates efficient addition of this modified nucleoside into oligonucleotides. This phosphoramidite is particularly useful for synthesizing oligonucleotides with enhanced stability, making it valuable for therapeutic applications, including antisense oligonucleotides and other RNA-based therapies.

CAT: BRP-02401

CAS: 1219089-77-6

Molecular Formula: C49H61N8O11PS2

Molecular Weight: 1033.17

Purity: ≥98%

Appearance: White to light yellow to light orange solid

Description: 2'-TC-C(Ac) Phosphoramidite is a modified phosphoramidite featuring a TC substitution on the ribose sugar and an acetyl (Ac) protecting group on the cytosine base's exocyclic amine. The 2'-thio modification significantly enhances the stability and nuclease resistance of the resulting oligonucleotides, improving their durability and performance in biological applications. The acetyl protection ensures the cytosine base remains stable and prevents undesired side reactions during synthesis. The 3'-cyanoethyl (CE) phosphoramidite group enables efficient incorporation into oligonucleotides using automated synthesis. This modification is widely used in the development of therapeutic oligonucleotides, such as antisense RNA, siRNA, and other applications requiring enhanced oligonucleotide stability.

CAT: BRP-02402

CAS: 1219089-87-8

Molecular Formula: C46H57N6O11PS2

Molecular Weight: 965.09

Purity: ≥98%

Appearance: White to light yellow to light orange solid

Description: 2'-TC-U Phosphoramidite is a modified phosphoramidite designed for oligonucleotide synthesis. It features a TC substitution on the ribose sugar, which enhances the chemical stability and nuclease resistance of the resulting oligonucleotides. The uracil base is left unprotected, allowing it to retain its natural hydrogen-bonding capabilities during hybridization. The 3'-cyanoethyl (CE) phosphoramidite group facilitates its efficient incorporation into oligonucleotide chains during automated synthesis. This modification is particularly valuable in creating oligonucleotides with increased durability and stability, making it suitable for applications in therapeutic nucleic acids, antisense technologies, and other RNA-based research.

CAT: BRP-02403

CAS: 1219089-92-5

Molecular Formula: C44H54N5O11PS2

Molecular Weight: 924.03

Purity: ≥98%

Appearance: White to light yellow to light orange solid

Description: 2'-O-MOE-A(Bz)-3'-Methoxy Phosphoramidite is a modified phosphoramidite designed for oligonucleotide synthesis. It features a 2'-O-methoxyethyl (MOE) modification on the ribose sugar, enhancing the stability, nuclease resistance, and binding affinity of the resulting oligonucleotides. The adenine base is protected with a benzoyl (Bz) group at the N6 position to prevent undesired side reactions during synthesis. The 3'-hydroxyl group is replaced by a methoxy group, offering unique structural properties and additional resistance to enzymatic degradation. The phosphoramidite functionality ensures efficient incorporation into oligonucleotide chains via automated synthesis. This compound is widely used in developing antisense oligonucleotides, siRNA, and other therapeutic nucleic acids requiring enhanced stability and performance.

CAT: BRP-02404

Molecular Formula: C48H57N6O9P

Molecular Weight: 892.99

Purity: ≥98%

Appearance: White, off-white to faint yellow powder

Description: 2'-OMe-A(Bz)-3'-Isopropyl Phosphoramidite is a modified phosphoramidite used for oligonucleotide synthesis. It contains a 2'-O-methyl (2'-OMe) group on the ribose sugar, which enhances the stability, nuclease resistance, and hybridization affinity of the resulting oligonucleotides. The adenine base is protected with a benzoyl (Bz) group at the N6 position to prevent undesired side reactions during synthesis. The 3'-isopropyl phosphoramidite group ensures efficient incorporation into oligonucleotide chains during automated synthesis. This modification is widely employed in the development of therapeutic nucleic acids, such as antisense oligonucleotides and siRNA, where increased stability and improved biological performance are essential.

CAT: BRP-02405

Molecular Formula: C48H57N6O8P

Molecular Weight: 876.99

Purity: ≥95%

Description: 2'-OMe-C(Ac)-3'-Isopropyl Phosphoramidite is a modified phosphoramidite used in oligonucleotide synthesis. The 2'-O-methyl (OMe) modification on the ribose sugar enhances the stability, nuclease resistance, and hybridization affinity of the resulting oligonucleotides. The cytosine base is protected with an acetyl (Ac) group at the N4 position, preventing unwanted side reactions during the synthesis process. The 3'-isopropyl phosphoramidite group facilitates efficient incorporation into oligonucleotide chains during automated synthesis. This modification is particularly valuable in applications where oligonucleotide stability, resistance to enzymatic degradation, and improved hybridization characteristics are important, such as in therapeutic nucleic acids, antisense oligonucleotides, and RNA-based technologies.

CAT: BRP-02406

Molecular Formula: C42H55N4O9P

Molecular Weight: 790.89

Purity: ≥95%

Description: 2'-OMe-G(iBu)-3'-Isopropyl Phosphoramidite is a modified phosphoramidite designed for oligonucleotide synthesis. It features a 2'-O-methyl (OMe) group on the ribose sugar, which enhances the stability, nuclease resistance, and hybridization properties of the resulting oligonucleotides. The guanine base is protected with an isobutyryl (iBu) group at the exocyclic amine to prevent side reactions during synthesis. At the 3' position, an isopropyl phosphoramidite group facilitates efficient incorporation into oligonucleotide chains during automated synthesis. This modification is particularly useful in creating oligonucleotides with enhanced stability and binding affinity, making it ideal for therapeutic applications such as antisense oligonucleotides, siRNA, and other RNA-based technologies.

CAT: BRP-02407

Molecular Formula: C45H59N6O9P

Molecular Weight: 858.97

Purity: ≥95%

Description: 2'-OMe-U-3'-Isopropyl Phosphoramidite is a modified uridine phosphoramidite used in oligonucleotide synthesis. The 2'-O-methyl (OMe) modification on the ribose sugar enhances the stability, nuclease resistance, and hybridization affinity of the resulting oligonucleotides. The uracil base remains unmodified at the 5-position, providing standard pairing properties during hybridization. The 3'-isopropyl phosphoramidite group ensures efficient incorporation into oligonucleotide chains during automated synthesis. This modification is particularly valuable for applications where increased stability, resistance to enzymatic degradation, and improved hybridization characteristics are needed, such as in therapeutic nucleic acids, antisense oligonucleotides, and RNA-based technologies.

CAT: BRP-02408

Molecular Formula: C40H52N3O9P

Molecular Weight: 749.84

Purity: ≥95%

Description: 2'-F-dA(Bz)-3'-Isopropyl Phosphoramidite is a fluorinated deoxyadenosine phosphoramidite used in oligonucleotide synthesis. It features a 2'-fluoro (2'-F) modification on the ribose sugar, which enhances the stability, nuclease resistance, and binding affinity of the resulting oligonucleotides. The adenine base is protected with a benzoyl (Bz) group at the N6 position to ensure stability and prevent side reactions during chemical synthesis. The 3'-isopropyl phosphoramidite group enables efficient and reliable incorporation into oligonucleotide chains during automated synthesis. This modification is particularly valuable for therapeutic applications, such as antisense oligonucleotides and siRNA, where enhanced durability, stability, and biological activity are critical.

CAT: BRP-02409

Molecular Formula: C47H54FN6O7P

Molecular Weight: 864.96

Purity: ≥95%