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C6-S-S-succinate
Description: C6-S-S-succinate is a chemical compound that features a disulfide bond (S-S) linking a C6 carbon chain to a succinate group. The structure typically consists of a six-carbon alkyl chain (C6) connected to a sulfur atom, which forms a disulfide linkage with another sulfur atom bonded to a succinate moiety. The disulfide bond is a reversible covalent bond, commonly used to control the release or activation of functional groups in chemical and biological systems. This compound is often utilized in bioconjugation, drug delivery, or the design of crosslinking agents where the disulfide bond can be cleaved under reducing conditions. In biological systems, disulfide bonds are essential for maintaining protein structure, and compounds like C6-S-S-succinate can be used in the development of controlled-release systems, biomolecular sensing, and targeting applications.
CAT: BRP-02446
CAS: 1191392-70-7
Molecular Formula: C37H48O7S2
Molecular Weight: 668.91
Purity: ≥98%
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Storage: Store at -20 °C
Density: 1.159±0.06 g/cm3
Boiling Point: 767.6±60.0 °C at 760 mmHg
InChIKey: KBIBZYXVEQTABM-UHFFFAOYSA-N
CanonicalSMILES: O=C(O)CCC(=O)OCCCCCCSSCCCCCCOC(C=1C=CC=CC1)(C2=CC=C(OC)C=C2)C3=CC=C(OC)C=C3
IUPAC Name: 4-((6-((6-(bis(4-methoxyphenyl)(phenyl)methoxy)hexyl)disulfaneyl)hexyl)oxy)-4-oxobutanoic acid
InChI: InChI=1S/C37H48O7S2/c1-41-33-20-16-31(17-21-33)37(30-14-8-7-9-15-30,32-18-22-34(42-2)23-19-32)44-27-11-4-6-13-29-46-45-28-12-5-3-10-26-43-36(40)25-24-35(38)39/h7-9,14-23H,3-6,10-13,24-29H2,1-2H3,(H,38,39)
Synonyms: Butanedioic acid, 1-[6-[[6-[bis(4-methoxyphenyl)phenylmethoxy]hexyl]dithio]hexyl] ester; 1-[6-[[6-[Bis(4-methoxyphenyl)phenylmethoxy]hexyl]dithio]hexyl] butanedioate; DMTr-C6-S-S-succinate; C6 S-S-DMTr-linker-succinate
GalNac-L96 (triethylamine salt)
Description: GalNAC-L96 is a triantennary GalNAc ligand that can be used for the synthesis of GalNAC-SiRNA and for the delivery of nucleic acid drugs. GalNAc is a ligand for the asialal glycoprotein receptor (ASGPR).
CAT: BRP-02447
CAS: 1159408-62-4
Molecular Formula: C127H194N12O45
Molecular Weight: 2608.95
Purity: ≥98%
Appearance: Off-white to Light Yellow Solid
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Storage: Store at -20 °C
InChIKey: IJXFTQRCIYIYHZ-MCDRDKEWSA-N
CanonicalSMILES: CCN(CC)CC.CC(=O)N[C@@H]1[C@H]([C@H]([C@H](O[C@H]1OCCCCC(=O)NCCCNC(=O)CCOCC(COCCC(=O)NCCCNC(=O)CCCCO[C@H]2[C@@H]([C@H]([C@H]([C@H](O2)COC(=O)C)OC(=O)C)OC(=O)C)NC(=O)C)(COCCC(=O)NCCCNC(=O)CCCCO[C@H]3[C@@H]([C@H]([C@H]([C@H](O3)COC(=O)C)OC(=O)C)OC(=O)C)NC(=O)C)NC(=O)CCCCCCCCCCC(=O)N4C[C@@H](C[C@H]4COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC)OC(=O)CCC(=O)O)COC(=O)C)OC(=O)C)OC(=O)C
IUPAC Name: 4-[(3R,5S)-1-[12-[[1,3-bis[3-[3-[5-[(2R,3R,4R,5R,6R)-3-acetamido-4,5-diacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxypentanoylamino]propylamino]-3-oxopropoxy]-2-[[3-[3-[5-[(2R,3R,4R,5R,6R)-3-acetamido-4,5-diacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxypentanoylamino]propylamino]-3-oxopropoxy]methyl]propan-2-yl]amino]-12-oxododecanoyl]-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]pyrrolidin-3-yl]oxy-4-oxobutanoic acid;N,N-diethylethanamine
InChI: InChI=1S/C121H179N11O45.C6H15N/c1-76(133)128-108-114(171-85(10)142)111(168-82(7)139)95(70-164-79(4)136)175-117(108)161-61-29-26-37-98(145)122-55-32-58-125-101(148)52-64-158-73-120(74-159-65-53-102(149)126-59-33-56-123-99(146)38-27-30-62-162-118-109(129-77(2)134)115(172-86(11)143)112(169-83(8)140)96(176-118)71-165-80(5)137,75-160-66-54-103(150)127-60-34-57-124-100(147)39-28-31-63-163-119-110(130-78(3)135)116(173-87(12)144)113(170-84(9)141)97(177-119)72-166-81(6)138)131-104(151)40-24-19-17-15-16-18-20-25-41-105(152)132-68-94(174-107(155)51-50-106(153)154)67-91(132)69-167-121(88-35-22-21-23-36-88,89-42-46-92(156-13)47-43-89)90-44-48-93(157-14)49-45-90;1-4-7(5-2)6-3/h21-23,35-36,42-49,91,94-97,108-119H,15-20,24-34,37-41,50-75H2,1-14H3,(H,122,145)(H,123,146)(H,124,147)(H,125,148)(H,126,149)(H,127,150)(H,128,133)(H,129,134)(H,130,135)(H,131,151)(H,153,154);4-6H2,1-3H3/t91-,94+,95+,96+,97+,108+,109+,110+,111-,112-,113-,114+,115+,116+,117+,118+,119+;/m0./s1
Synonyms: L96.TEA; N-Acetylgalactosamine-L96 triethylamine salt; N-acetyl-D-Galactosamine-L96 triethylamine salt
Related CAS: 1159408-61-3 (free base)
Lipig
Description: Lipig is a product related to GalNAc (n-acetylgalactosamine) whose primary use is in the field of targeted drug delivery, particularly in the liver.
CAT: BRP-02448
CAS: 1332358-27-6
Molecular Formula: C78H125N7O42
Molecular Weight: 1832.85
Purity: ≥95%
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Storage: Store at -20 °C
Density: 1.339±0.10 g/cm3
Boiling Point: 1532.1±65.0 °C at 760 mmHg
InChIKey: RNUIVLALNYHRTI-OIZVDVEISA-N
CanonicalSMILES: CC(=O)N[C@@H]1[C@H]([C@H]([C@H](O[C@H]1OCCOCCOCCOCC(=O)NCCCC[C@@H](C(=O)N[C@@H](CCCCNC(=O)COCCOCCOCCO[C@H]2[C@@H]([C@H]([C@H]([C@H](O2)COC(=O)C)OC(=O)C)OC(=O)C)NC(=O)C)C(=O)O)NC(=O)COCCOCCOCCO[C@H]3[C@@H]([C@H]([C@H]([C@H](O3)COC(=O)C)OC(=O)C)OC(=O)C)NC(=O)C)COC(=O)C)OC(=O)C)OC(=O)C
IUPAC Name: (2S)-6-[[2-[2-[2-[2-[(2R,3R,4R,5R,6R)-3-acetamido-4,5-diacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxyethoxy]ethoxy]ethoxy]acetyl]amino]-2-[[(2S)-2,6-bis[[2-[2-[2-[2-[(2R,3R,4R,5R,6R)-3-acetamido-4,5-diacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxyethoxy]ethoxy]ethoxy]acetyl]amino]hexanoyl]amino]hexanoic acid
InChI: InChI=1S/C78H125N7O42/c1-45(86)81-65-71(122-54(10)95)68(119-51(7)92)59(39-116-48(4)89)125-76(65)113-36-33-107-24-21-104-27-30-110-42-62(98)79-19-15-13-17-57(84-64(100)44-112-32-29-106-23-26-109-35-38-115-78-67(83-47(3)88)73(124-56(12)97)70(121-53(9)94)61(127-78)41-118-50(6)91)74(101)85-58(75(102)103)18-14-16-20-80-63(99)43-111-31-28-105-22-25-108-34-37-114-77-66(82-46(2)87)72(123-55(11)96)69(120-52(8)93)60(126-77)40-117-49(5)90/h57-61,65-73,76-78H,13-44H2,1-12H3,(H,79,98)(H,80,99)(H,81,86)(H,82,87)(H,83,88)(H,84,100)(H,85,101)(H,102,103)/t57-,58-,59+,60+,61+,65+,66+,67+,68-,69-,70-,71+,72+,73+,76+,77+,78+/m0/s1
Synonyms: N2,N6-Bis[2-[2-[2-[2-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]ethoxy]ethoxy]ethoxy]acetyl]-L-lysyl-N6-[2-[2-[2-[2-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]ethoxy]ethoxy]ethoxy]acetyl]-L-lysine; (17S,20S)-1-(((2R,3R,4R,5R,6R)-3-Acetamido-4,5-diacetoxy-6-(acetoxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-20-(1-(((2R,3R,4R,5R,6R)-3-acetamido-4,5-diacetoxy-6-(acetoxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-11-oxo-3,6,9-trioxa-12-azahexadecan-16-yl)-17-(2-(2-(2-(2-(((2R,3R,4R,5R,6R)-3-acetamido-4,5-diacetoxy-6-(acetoxymethyl)tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethoxy)acetamido)-11,18-dioxo-3,6,9-trioxa-12,19-diazahenicosan-21-oic acid
GalNAc-L96-PS
Description: GalNAc-L96-PS is a conjugated molecule featuring a GalNAc (N-acetylgalactosamine) ligand for targeted delivery, an L96 linker for structural and functional optimization, and a PS backbone modification to enhance nuclease resistance. It is used in the synthesis of liver-targeted oligonucleotide therapeutics, where the GalNAc ligand ensures selective uptake by hepatocytes through the asialoglycoprotein receptor (ASGPR). This compound is a critical component in the development of antisense oligonucleotides (ASOs) and siRNA drugs, providing improved stability, specificity, and efficacy in the treatment of liver-associated diseases.
CAT: BRP-02449
Purity: ≥95%
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Storage: Store at -20 °C
3,3'-[[2-(Cbz-amino)-2-[[3-[[3-(Boc-amino)propyl]amino]-3-oxopropoxy]methyl]propane-1,3-diyl]bis(oxy)]bis[N-[3-(Boc-amino)propyl]propanamide]
Description: It is an L96-related intermediate utilized in synthetic chemistry, particularly in the preparation of dendrimers, peptide conjugates, or advanced drug delivery systems, where its protective groups facilitate controlled sequential reactions. It is commonly applied in constructing complex molecules for targeted therapies, ensuring stability and precise functionalization in biochemical and pharmaceutical contexts.
CAT: BRP-02450
CAS: 1162069-31-9
Molecular Formula: C45H77N7O14
Molecular Weight: 940.13
Purity: ≥95%
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Storage: Store at -20 °C
Density: 1.147±0.06 g/cm3
Boiling Point: 1067.1±65.0 °C at 760 mmHg
InChIKey: NEGMHOPQXWCPBK-UHFFFAOYSA-N
CanonicalSMILES: CC(C)(C)OC(=O)NCCCNC(=O)CCOCC(COCCC(=O)NCCCNC(=O)OC(C)(C)C)(COCCC(=O)NCCCNC(=O)OC(C)(C)C)NC(=O)OCC1=CC=CC=C1
IUPAC Name: benzyl N-[1,3-bis[3-[3-[(2-methylpropan-2-yl)oxycarbonylamino]propylamino]-3-oxopropoxy]-2-[[3-[3-[(2-methylpropan-2-yl)oxycarbonylamino]propylamino]-3-oxopropoxy]methyl]propan-2-yl]carbamate
InChI: InChI=1S/C45H77N7O14/c1-42(2,3)64-38(56)49-24-13-21-46-35(53)18-27-60-31-45(52-41(59)63-30-34-16-11-10-12-17-34,32-61-28-19-36(54)47-22-14-25-50-39(57)65-43(4,5)6)33-62-29-20-37(55)48-23-15-26-51-40(58)66-44(7,8)9/h10-12,16-17H,13-15,18-33H2,1-9H3,(H,46,53)(H,47,54)(H,48,55)(H,49,56)(H,50,57)(H,51,58)(H,52,59)
Synonyms: 10,14-Dioxa-2,6,18,22-tetraazatricosanedioic acid, 12-(13,13-dimethyl-5,11-dioxo-2,12-dioxa-6,10-diazatetradec-1-yl)-7,17-dioxo-12-[[(phenylmethoxy)carbonyl]amino]-, 1,23-bis(1,1-dimethylethyl) ester; 1,23-Bis(1,1-dimethylethyl) 12-(13,13-dimethyl-5,11-dioxo-2,12-dioxa-6,10-diazatetradec-1-yl)-7,17-dioxo-12-[[(phenylmethoxy)carbonyl]amino]-10,14-dioxa-2,6,18,22-tetraazatricosanedioate; Benzyl di-tert-butyl (10-(13,13-dimethyl-5,11-dioxo-2,12-dioxa-6,10-diazatetradecyl)-5,15-dioxo-8,12-dioxa-4,16-diazanonadecane-1,10,19-triyl)tricarbamate
(3R,5S)-5-([Bis(4-methoxyphenyl)(phenyl)methoxy]methyl)pyrrolidin-3-ol
Description: It is an L96-related intermediate used in drug delivery systems and biochemical research. The pyrrolidine core is a versatile scaffold for creating biologically active molecules, and the aromatic methoxyphenyl groups may contribute to interactions with hydrophobic pockets in biological targets. It is useful for designing compounds with specific stereochemical properties, potentially for enzyme inhibition or receptor targeting.
CAT: BRP-02451
CAS: 151953-64-9
Molecular Formula: C26H29NO4
Molecular Weight: 419.52
Purity: ≥97%
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Storage: Store at -20 °C
Density: 1.160±0.06 g/cm3
Boiling Point: 569.4±50.0 °C at 760 mmHg
InChIKey: CJFYBUJBXCVKLN-XZOQPEGZSA-N
CanonicalSMILES: COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)OC[C@@H]4C[C@H](CN4)O
IUPAC Name: (3R,5S)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]pyrrolidin-3-ol
InChI: InChI=1S/C26H29NO4/c1-29-24-12-8-20(9-13-24)26(19-6-4-3-5-7-19,21-10-14-25(30-2)15-11-21)31-18-22-16-23(28)17-27-22/h3-15,22-23,27-28H,16-18H2,1-2H3/t22-,23+/m0/s1
Synonyms: 3-Pyrrolidinol, 5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-, (3R,5S)-; (3R,5S)-5-[[Bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-pyrrolidinol; 3-Pyrrolidinol, 5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-, (3R-trans)-
