Phosphoramidites - RNA / BOC Sciences

DMTr-2'-O-MOE-rA(Bz)-3'-((2-cyanoethoxy)(diisopropylamino) phosphoramidite)-ethyl-diisopropylphosphoramidite

Description: DMTr-2'-O-MOE-rA(Bz)-3'-((2-cyanoethoxy)(diisopropylamino) phosphoramidite)-ethyl-diisopropylphosphoramidite is utilized in oligonucleotide synthesis. It is employed to introduce modified adenosine residues with altered chemical properties into nucleic acid sequences, suitable for applications such as RNA interference (RNAi), gene silencing, and nucleic acid therapeutics.

CAT: BRP-00581

MF: C58H76N8O11P2

MF: 1123.24

Purity: ≥93%

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InChIKey: PAPVZRWLBSUSMQ-SXPYXJKBSA-N

IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl (2-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)ethyl) diisopropylphosphoramidite

InChI: InChI=1S/C58H76N8O11P2/c1-40(2)65(41(3)4)78(73-32-18-31-59)74-35-36-75-79(66(42(5)6)43(7)8)77-52-50(37-72-58(45-21-16-13-17-22-45,46-23-27-48(69-10)28-24-46)47-25-29-49(70-11)30-26-47)76-57(53(52)71-34-33-68-9)64-39-62-51-54(60-38-61-55(51)64)63-56(67)44-19-14-12-15-20-44/h12-17,19-30,38-43,50,52-53,57H,18,32-37H2,1-11H3,(H,60,61,63,67)/t50-,52-,53-,57-,78?,79?/m1/s1

DMTr-2'-O-MOE-rG(iBu)-3'-(L)-PSM-Phosphoramidite

Description: DMTr-2'-O-MOE-rG(iBu)-3'-(L)-PSM-Phosphoramidite is utilized in oligonucleotide synthesis. It is employed to introduce modified guanosine residues with altered chemical properties into nucleic acid sequences, suitable for applications such as antisense technology, RNA interference (RNAi), and gene regulation research.

CAT: BRP-00582

CAS: 2379296-19-0

MF: C50H57N6O12PS

MF: 997.07

Purity: ≥98%

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InChIKey: BIELQCFHRDHWIK-VZEHQRRASA-N

CanonicalSMILES: O=C1N=C(NC(=O)C(C)C)NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP7OC(CS(=O)(=O)C=8C=CC=CC8)C9N7CCC9)C3OCCOC

IUPAC Name: N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-(2-methoxyethoxy)-4-(((1S,3S,3aS)-3-((phenylsulfonyl)methyl)tetrahydro-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaphosphol-1-yl)oxy)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide

InChI: InChI=1S/C50H57N6O12PS/c1-32(2)46(57)53-49-52-45-42(47(58)54-49)51-31-55(45)48-44(64-28-27-61-3)43(68-69-56-26-12-17-39(56)41(67-69)30-70(59,60)38-15-10-7-11-16-38)40(66-48)29-65-50(33-13-8-6-9-14-33,34-18-22-36(62-4)23-19-34)35-20-24-37(63-5)25-21-35/h6-11,13-16,18-25,31-32,39-41,43-44,48H,12,17,26-30H2,1-5H3,(H2,52,53,54,57,58)/t39-,40+,41+,43+,44+,48+,69+/m0/s1

Synonyms: Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-N-(2-methyl-1-oxopropyl)-3'-O-[(1S,3S,3aS)-tetrahydro-3-[(phenylsulfonyl)methyl]-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaphosphol-1-yl]-

DMTr-2'-O-MOE-rG(dmf)-3'-(L)-PSM-Phosphoramidite

Description: DMTr-2'-O-MOE-rG(dmf)-3'-(L)-PSM-Phosphoramidite is utilized in oligonucleotide synthesis. It is employed to introduce modified guanosine residues with altered chemical properties into nucleic acid sequences, suitable for applications such as antisense technology, RNA interference (RNAi), and gene regulation research.

CAT: BRP-00583

MF: C49H56N7O11PS

MF: 982.06

Purity: ≥98%

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InChIKey: KSGZFWPZSAYMSD-FSWBDJQRSA-N

IUPAC Name: N'-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-(2-methoxyethoxy)-4-(((1S,3S,3aS)-3-((phenylsulfonyl)methyl)tetrahydro-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaphosphol-1-yl)oxy)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethylformimidamide

InChI: InChI=1S/C49H56N7O11PS/c1-54(2)31-51-48-52-45-42(46(57)53-48)50-32-55(45)47-44(63-28-27-60-3)43(67-68-56-26-12-17-39(56)41(66-68)30-69(58,59)38-15-10-7-11-16-38)40(65-47)29-64-49(33-13-8-6-9-14-33,34-18-22-36(61-4)23-19-34)35-20-24-37(62-5)25-21-35/h6-11,13-16,18-25,31-32,39-41,43-44,47H,12,17,26-30H2,1-5H3,(H,52,53,57)/t39-,40+,41+,43+,44+,47+,68+/m0/s1

Synonyms: 5'-O-DMT-2'-O-MOE-G(dmf)-3'-(L)-PSM-Phosphoramidite

DMTr-2'-O-MOE-5-Me-rC(Bz)-3'-(L)-PSM-Phosphoramidite

Description: DMTr-2'-O-MOE-5-Me-rC(Bz)-3'-(L)-PSM-Phosphoramidite is utilized in oligonucleotide synthesis. It is employed to introduce modified cytidine residues with altered chemical properties into nucleic acid sequences, suitable for applications such as antisense technology, RNA interference (RNAi), and gene regulation research.

CAT: BRP-00584

CAS: 2379296-21-4

MF: C53H57N4O12PS

MF: 1005.09

Purity: ≥98%

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InChIKey: UUMRAIRUULBYGT-PRACXZEXSA-N

CanonicalSMILES: O=C1N=C(NC(=O)C=2C=CC=CC2)C(=CN1C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP7OC(CS(=O)(=O)C=8C=CC=CC8)C9N7CCC9)C3OCCOC)C

IUPAC Name: N-(1-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-(2-methoxyethoxy)-4-(((1S,3S,3aS)-3-((phenylsulfonyl)methyl)tetrahydro-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaphosphol-1-yl)oxy)tetrahydrofuran-2-yl)-5-methyl-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide

InChI: InChI=1S/C53H57N4O12PS/c1-36-33-56(52(59)55-49(36)54-50(58)37-15-8-5-9-16-37)51-48(65-32-31-62-2)47(69-70-57-30-14-21-44(57)46(68-70)35-71(60,61)43-19-12-7-13-20-43)45(67-51)34-66-53(38-17-10-6-11-18-38,39-22-26-41(63-3)27-23-39)40-24-28-42(64-4)29-25-40/h5-13,15-20,22-29,33,44-48,51H,14,21,30-32,34-35H2,1-4H3,(H,54,55,58,59)/t44-,45+,46+,47+,48+,51+,70+/m0/s1

Synonyms: Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-3'-O-[(1S,3S,3aS)-tetrahydro-3-[(phenylsulfonyl)methyl]-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaphosphol-1-yl]-

DMTr-2'-O-(Methyl palmitate)-rU-3'-CE-Phosphoramidite

Description: DMTr-2'-O-(Methyl palmitate)-rU-3'-CE-Phosphoramidite is utilized in oligonucleotide synthesis. It is employed to introduce modified uridine residues with altered chemical properties into nucleic acid sequences, suitable for applications such as RNA interference (RNAi), gene silencing, and nucleic acid therapeutics.

CAT: BRP-00585

CAS: 2642320-25-8

MF: C56H79N4O11P

MF: 1015.24

Purity: ≥98%

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InChIKey: NWFCOAVWTXVSHI-GWCNJYPESA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=CC(=O)NC2=O)C1OCCCCCCCCCCCCCCCC(=O)OC)COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)N(C(C)C)C(C)C

IUPAC Name: methyl 16-(((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)oxy)hexadecanoate

InChI: InChI=1S/C56H79N4O11P/c1-42(2)60(43(3)4)72(69-40-24-37-57)71-52-49(41-68-56(44-25-20-19-21-26-44,45-28-32-47(64-5)33-29-45)46-30-34-48(65-6)35-31-46)70-54(59-38-36-50(61)58-55(59)63)53(52)67-39-23-18-16-14-12-10-8-9-11-13-15-17-22-27-51(62)66-7/h19-21,25-26,28-36,38,42-43,49,52-54H,8-18,22-24,27,39-41H2,1-7H3,(H,58,61,63)/t49-,52-,53-,54-,72?/m1/s1

Synonyms: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(16-methoxy-16-oxohexadecyl)-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

DMTr-2'-O-C16-rU-3'-CE-Phosphoramidite

Description: DMTr-2'-O-C16-rU-3'-CE-Phosphoramidite is utilized in oligonucleotide synthesis. It is employed to introduce modified uridine residues with altered chemical properties into nucleic acid sequences, suitable for applications such as RNA interference (RNAi), gene silencing, and nucleic acid therapeutics.

CAT: BRP-00586

CAS: 2382942-83-6

MF: C55H79N4O9P

MF: 971.21

Purity: ≥98%

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InChIKey: MGKJVGDGCZEJKK-KSNSTLKFSA-N

CanonicalSMILES: CCCCCCCCCCCCCCCCOC1C(C(OC1N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(2,4-dioxopyrimidin-1-yl)-4-hexadecoxyoxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C55H79N4O9P/c1-8-9-10-11-12-13-14-15-16-17-18-19-20-24-39-64-52-51(68-69(66-40-25-37-56)59(42(2)3)43(4)5)49(67-53(52)58-38-36-50(60)57-54(58)61)41-65-55(44-26-22-21-23-27-44,45-28-32-47(62-6)33-29-45)46-30-34-48(63-7)35-31-46/h21-23,26-36,38,42-43,49,51-53H,8-20,24-25,39-41H2,1-7H3,(H,57,60,61)/t49-,51-,52-,53-,69?/m1/s1

Synonyms: O-C16-rU-3'-CE-Phosphoramidite; 2'-O-C16-U phosphoramidite; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-hexadecyl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

DMTr-2'-O-C16-rC(Ac)-3'-CE-Phosphoramidite

Description: DMTr-2'-O-C16-rC(Ac)-3'-CE-Phosphoramidite is utilized in oligonucleotide synthesis. It is employed to introduce modified cytidine residues with altered chemical properties into nucleic acid sequences, suitable for applications such as RNA interference (RNAi), gene silencing, and nucleic acid therapeutics.

CAT: BRP-00587

CAS: 2382942-38-1

MF: C57H82N5O9P

MF: 1012.28

Purity: ≥98%

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InChIKey: NMBMTBHXQJMTLO-LCKVQZKFSA-N

CanonicalSMILES: CCCCCCCCCCCCCCCCOC1C(C(OC1N2C=CC(=NC2=O)NC(=O)C)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-hexadecoxyoxolan-2-yl]-2-oxopyrimidin-4-yl]acetamide

InChI: InChI=1S/C57H82N5O9P/c1-9-10-11-12-13-14-15-16-17-18-19-20-21-25-40-67-54-53(71-72(69-41-26-38-58)62(43(2)3)44(4)5)51(70-55(54)61-39-37-52(59-45(6)63)60-56(61)64)42-68-57(46-27-23-22-24-28-46,47-29-33-49(65-7)34-30-47)48-31-35-50(66-8)36-32-48/h22-24,27-37,39,43-44,51,53-55H,9-21,25-26,40-42H2,1-8H3,(H,59,60,63,64)/t51-,53-,54-,55-,72?/m1/s1

Synonyms: 2'-O-C16-C(Ac) phosphoramidite; Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-hexadecyl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

DMTr-2'-O-C16-rG(iBu)-3'-CE-Phosphoramidite

Description: DMTr-2'-O-C16-rG(iBu)-3'-CE-Phosphoramidite is utilized in oligonucleotide synthesis. It is employed to introduce modified guanosine residues with altered chemical properties into nucleic acid sequences, suitable for applications such as RNA interference (RNAi), gene silencing, and nucleic acid therapeutics.

CAT: BRP-00588

CAS: 2382942-32-5

MF: C60H86N7O9P

MF: 1080.36

Purity: ≥98%

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InChIKey: UOYPBRBOXKOJLE-ZGTMVWBUSA-N

CanonicalSMILES: CCCCCCCCCCCCCCCCOC1C(C(OC1N2C=NC3=C2N=C(NC3=O)NC(=O)C(C)C)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-hexadecoxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide

InChI: InChI=1S/C60H86N7O9P/c1-10-11-12-13-14-15-16-17-18-19-20-21-22-26-39-72-54-53(76-77(74-40-27-38-61)67(44(4)5)45(6)7)51(75-58(54)66-42-62-52-55(66)63-59(65-57(52)69)64-56(68)43(2)3)41-73-60(46-28-24-23-25-29-46,47-30-34-49(70-8)35-31-47)48-32-36-50(71-9)37-33-48/h23-25,28-37,42-45,51,53-54,58H,10-22,26-27,39-41H2,1-9H3,(H2,63,64,65,68,69)/t51-,53-,54-,58-,77?/m1/s1

Synonyms: N2-iBu-5'-O-DMTr-2'-O-hexadecanyl guanosine 3'-CED phosphoramidite; 2'-O-C16-G(iBu) phosphoramidite; Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-hexadecyl-N-(2-methyl-1-oxopropyl)-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

DMTr-2'-ara-OAc-U-3'-CE-Phosphoramidite

Description: DMTr-2'-ara-OAc-U-3'-CE-Phosphoramidite is utilized in oligonucleotide synthesis. It is employed to introduce modified uridine residues with altered chemical properties into nucleic acid sequences, suitable for applications such as RNA interference (RNAi), gene silencing, and nucleic acid therapeutics.

CAT: BRP-00589

CAS: 173099-63-3

MF: C41H49N4O10P

MF: 788.83

Purity: ≥98%

Appearance: Off-white solid

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InChIKey: XQPRAGYYSCIUMN-KEZDHIJLSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=CC(=O)NC2=O)C1OC(=O)C)COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)N(C(C)C)C(C)C

IUPAC Name: (2R,3S,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl acetate

InChI: InChI=1S/C41H49N4O10P/c1-27(2)45(28(3)4)56(52-25-11-23-42)55-37-35(54-39(38(37)53-29(5)46)44-24-22-36(47)43-40(44)48)26-51-41(30-12-9-8-10-13-30,31-14-18-33(49-6)19-15-31)32-16-20-34(50-7)21-17-32/h8-10,12-22,24,27-28,35,37-39H,11,25-26H2,1-7H3,(H,43,47,48)/t35-,37-,38+,39-,56?/m1/s1

Synonyms: 5'-O-(4,4'-dimethoxytrityl)-2'-O-acetyl-arabinouridine-3'-[(2-cyanoethyl)-(N,N-diisopropropyl)]-Phosphoramidite; 5'-O-DMTr-2'-ara-OAc-U-3'-CE-Phosphoramidite; 1-[2-O-Acetyl-5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-β-D-arabinofuranosyl]-2,4(1H,3H)-pyrimidinedione; ANA 2'-OAc U amidite; Ara-U-amidite

DMTr-2'-ara-OAc-G(iBu)-3'-CE-Phosphoramidite

Description: DMTr-2'-ara-OAc-G(iBu)-3'-CE-Phosphoramidite is utilized in oligonucleotide synthesis. It is employed to introduce modified guanosine residues with altered chemical properties into nucleic acid sequences, suitable for applications such as RNA interference (RNAi), gene silencing, and nucleic acid therapeutics.

CAT: BRP-00590

CAS: 160684-51-5

MF: C46H56N7O10P

MF: 897.38

Purity: ≥98%

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InChIKey: QLYLXXFVZIYNFL-CMURLGQCSA-N

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N(C(C)C)C(C)C)OCCC#N)OC(=O)C

IUPAC Name: [(2R,3S,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-2-[2-(2-methylpropanoylamino)-6-oxo-1H-purin-9-yl]oxolan-3-yl] acetate

InChI: InChI=1S/C46H56N7O10P/c1-28(2)42(55)50-45-49-41-38(43(56)51-45)48-27-52(41)44-40(61-31(7)54)39(63-64(60-25-13-24-47)53(29(3)4)30(5)6)37(62-44)26-59-46(32-14-11-10-12-15-32,33-16-20-35(57-8)21-17-33)34-18-22-36(58-9)23-19-34/h10-12,14-23,27-30,37,39-40,44H,13,25-26H2,1-9H3,(H2,49,50,51,55,56)/t37-,39-,40+,44-,64?/m1/s1

Synonyms: N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O-acetyl-arabinoguanosine-3'-[(2-cyanoethyl)-(N,N-diisopropropyl)]-Phosphoramidite; 5'-O-DMTr-2'-ara-OAc-G(ibu)-3'-CE-Phosphoramidite; N-[9-[2-O-Acetyl-5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-β-D-arabinofuranosyl]-6,9-dihydro-6-oxo-1H-purin-2-yl]-2-methylpropanamide; Phosphoramidous acid, bis(1-methylethyl)-, mono(2-cyanoethyl) ester, ester with N-[9-[2-O-acetyl-5-O-[bis(4-methoxyphenyl)phenylmethyl]-β-D-arabinofuranosyl]-6,9-dihydro-6-oxo-1H-purin-2-yl]-2-methylpropanamide; Ara-G-amidite

DMTr-2'-ara-OAc-A(Bz)-3'-CE-Phosphoramidite

Description: DMTr-2'-ara-OAc-A(Bz)-3'-CE-Phosphoramidite is utilized in oligonucleotide synthesis. It is employed to introduce modified adenosine residues with altered chemical properties into nucleic acid sequences, suitable for applications such as RNA interference (RNAi), gene silencing, and nucleic acid therapeutics.

CAT: BRP-00591

CAS: 2756253-85-5

MF: C49H54N7O9P

MF: 915.98

Purity: ≥95%

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InChIKey: QLQIHUMYIFDYEK-ASTLELISSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C(=NC=NC32)NC(=O)C=4C=CC=CC4)C1OC(=O)C)COC(C=5C=CC=CC5)(C6=CC=C(OC)C=C6)C7=CC=C(OC)C=C7)N(C(C)C)C(C)C

IUPAC Name: (2R,3S,4R,5R)-2-(6-benzamido-9H-purin-9-yl)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)tetrahydrofuran-3-yl acetate

InChI: InChI=1S/C49H54N7O9P/c1-32(2)56(33(3)4)66(62-28-14-27-50)65-43-41(29-61-49(36-17-12-9-13-18-36,37-19-23-39(59-6)24-20-37)38-21-25-40(60-7)26-22-38)64-48(44(43)63-34(5)57)55-31-53-42-45(51-30-52-46(42)55)54-47(58)35-15-10-8-11-16-35/h8-13,15-26,30-33,41,43-44,48H,14,28-29H2,1-7H3,(H,51,52,54,58)/t41-,43-,44+,48-,66?/m1/s1

Synonyms: 5'-O-DMTr-2'-ara-OAc-A(Bz)-3'-CE-Phosphoramidite; N6-benzoyl-(5'-O-(4,4'-dimethoxytrityl)-2'-O-acetyl-arabinoadenosine-3'-[(2-cyanoethyl)-(N,N-diisopropropyl)]-Phosphoramidite; Benzamide, N-[9-[2-O-acetyl-5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-β-D-arabinofuranosyl]-9H-purin-6-yl]-; Adenosine Arabinoside

3'-O-DMTr-2'-O-MOE-5-Me-rC(Bz)-5'-CE-Phosphoramidite

Description: 3'-O-DMTr-2'-O-MOE-5-Me-rC(Bz)-5'-CE-Phosphoramidite is a specialized nucleotide used in oligonucleotide synthesis. It contains a 3'-dimethoxytrityl (DMTr) protecting group on the 3' hydroxyl, a 2'-O-methoxyethyl (MOE) modification at the 2' position of the ribose sugar, a methyl (Me) modification at the 5' position of the cytosine base, and a benzoyl (Bz) protecting group on the cytosine amino group. Additionally, it features a 5'-cyanoethyl (CE) phosphoramidite functionality for controlled addition during synthesis. This compound facilitates stable and precise synthesis of customized oligonucleotides, useful for various molecular biology research applications.

CAT: BRP-00592

CAS: 3025999-57-6

MF: C50H60N5O10P

MF: 922.03

Purity: ≥98%

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InChIKey: LGQSXYUXQBROPP-GICDFOIUSA-N

CanonicalSMILES: CC1=CN(C(=O)N=C1NC(=O)C2=CC=CC=C2)C3C(C(C(O3)COP(N(C(C)C)C(C)C)OCCC#N)OC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OCCOC

IUPAC Name: N-[1-[(2R,3R,4R,5R)-4-[bis(4-methoxyphenyl)-phenylmethoxy]-5-[[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxymethyl]-3-(2-methoxyethoxy)oxolan-2-yl]-5-methyl-2-oxopyrimidin-4-yl]benzamide

InChI: InChI=1S/C50H60N5O10P/c1-34(2)55(35(3)4)66(62-29-15-28-51)63-33-43-44(65-50(38-18-13-10-14-19-38,39-20-24-41(59-7)25-21-39)40-22-26-42(60-8)27-23-40)45(61-31-30-58-6)48(64-43)54-32-36(5)46(53-49(54)57)52-47(56)37-16-11-9-12-17-37/h9-14,16-27,32,34-35,43-45,48H,15,29-31,33H2,1-8H3,(H,52,53,56,57)/t43-,44-,45-,48-,66?/m1/s1

Synonyms: Rev 2'-O-MOE-5MeC(Bz)-5'-amidite; ((2R,3R,4R,5R)-5-(4-benzamido-5-methyl-2-oxopyrimidin-1(2H)-yl)-3-(bis(4-methoxyphenyl)(phenyl)methoxy)-4-(2-methoxyethoxy)tetrahydrofuran-2-yl)methyl (2-cyanoethyl) diisopropylphosphoramidite

3'-O-DMTr-2'-O-MOE-rA(Bz)-5'-CE-Phosphoramidite

Description: 3'-O-DMTr-2'-O-MOE-rA(Bz)-5'-CE-Phosphoramidite is a specialized nucleotide derivative used in oligonucleotide synthesis. It features a 3'-dimethoxytrityl (DMTr) protecting group on the 3' hydroxyl, a 2'-O-methoxyethyl (MOE) modification at the 2' position of the ribose sugar, and a benzoyl (Bz) protecting group on the adenine (A) base. Additionally, it contains a 5'-cyanoethyl (CE) phosphoramidite functionality, enabling controlled addition during synthesis. This compound facilitates stable and precise synthesis of customized oligonucleotides, making it valuable for molecular biology research applications.

CAT: BRP-00593

CAS: 3025999-68-9

MF: C50H58N7O9P

MF: 932.03

Purity: ≥95%

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InChIKey: XNXRGROTYZFYBK-HDMAWCRFSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OCC1C(C(C(O1)N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)OCCOC)OC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC

IUPAC Name: N-[9-[(2R,3R,4R,5R)-4-[bis(4-methoxyphenyl)-phenylmethoxy]-5-[[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxymethyl]-3-(2-methoxyethoxy)oxolan-2-yl]purin-6-yl]benzamide

InChI: InChI=1S/C50H58N7O9P/c1-34(2)57(35(3)4)67(63-28-14-27-51)64-31-42-44(66-50(37-17-12-9-13-18-37,38-19-23-40(60-6)24-20-38)39-21-25-41(61-7)26-22-39)45(62-30-29-59-5)49(65-42)56-33-54-43-46(52-32-53-47(43)56)55-48(58)36-15-10-8-11-16-36/h8-13,15-26,32-35,42,44-45,49H,14,28-31H2,1-7H3,(H,52,53,55,58)/t42-,44-,45-,49-,67?/m1/s1

Synonyms: Rev 2'-O-MOE-A(Bz)-5'-amidite; ((2R,3R,4R,5R)-5-(6-Benzamido-9H-purin-9-yl)-3-(bis(4-methoxyphenyl)(phenyl)methoxy)-4-(2-methoxyethoxy)tetrahydrofuran-2-yl)methyl (2-cyanoethyl) diisopropylphosphoramidite

3'-O-DMTr-2'-O-MOE-rG(iBu)-5'-CE-Phosphoramidite

Description: 3'-O-DMTr-2'-O-MOE-rG(iBu)-5'-CE-Phosphoramidite is a specialized nucleotide derivative used in oligonucleotide synthesis. It features a 3'-dimethoxytrityl (DMTr) protecting group on the 3' hydroxyl, a 2'-O-methoxyethyl (MOE) modification at the 2' position of the ribose sugar, and a benzoyl (Bz) protecting group on the adenine (A) base. Additionally, it contains a 5'-cyanoethyl (CE) phosphoramidite functionality, enabling controlled addition during synthesis. This compound facilitates stable and precise synthesis of customized oligonucleotides, making it valuable for molecular biology research applications.

CAT: BRP-00594

CAS: 725223-44-9

MF: C47H60N7O10P

MF: 914.00

Purity: ≥98%

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InChIKey: YLDSIMQFLQLTEA-SBCRAQIVSA-N

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)COP(N(C(C)C)C(C)C)OCCC#N)OC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OCCOC

IUPAC Name: N-[9-[(2R,3R,4R,5R)-4-[bis(4-methoxyphenyl)-phenylmethoxy]-5-[[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxymethyl]-3-(2-methoxyethoxy)oxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide

InChI: InChI=1S/C47H60N7O10P/c1-30(2)43(55)51-46-50-42-39(44(56)52-46)49-29-53(42)45-41(60-27-26-57-7)40(38(63-45)28-62-65(61-25-13-24-48)54(31(3)4)32(5)6)64-47(33-14-11-10-12-15-33,34-16-20-36(58-8)21-17-34)35-18-22-37(59-9)23-19-35/h10-12,14-23,29-32,38,40-41,45H,13,25-28H2,1-9H3,(H2,50,51,52,55,56)/t38-,40-,41-,45-,65?/m1/s1

Synonyms: Rev 2'-O-MOE-G(iBu)-5'-amidite; Guanosine, 3'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-N-(2-methyl-1-oxopropyl)-, 5'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

U PMO Monomer

Description: U PMO Monomer is a monomer used in the synthesis of peptide-conjugated morpholino oligomers (PMO). PMOs are synthetic nucleic acid analogs designed for antisense therapy and gene expression modulation. The ''U'' designation indicates that the monomer is based on uracil, a nucleobase commonly used in nucleic acid analogs. These monomers are incorporated into PMOs to specifically target and bind complementary RNA sequences, thereby interfering with gene expression or splicing mechanisms.

CAT: BRP-00595

CAS: 2388517-98-2

MF: C30H32ClN4O5P

MF: 595.03

Purity: ≥98%

Appearance: White to faint yellow powder

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Density: 1.320±0.06 g/cm3

InChIKey: GCLNBTZDWZLIOP-JOLGRYLWSA-N

CanonicalSMILES: CN(C)P(=O)(OCC1CN(CC(O1)N2C=CC(=O)NC2=O)C(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)Cl

IUPAC Name: 1-[(2R,6S)-6-[[chloro(dimethylamino)phosphoryl]oxymethyl]-4-tritylmorpholin-2-yl]pyrimidine-2,4-dione

InChI: InChI=1S/C30H32ClN4O5P/c1-33(2)41(31,38)39-22-26-20-34(21-28(40-26)35-19-18-27(36)32-29(35)37)30(23-12-6-3-7-13-23,24-14-8-4-9-15-24)25-16-10-5-11-17-25/h3-19,26,28H,20-22H2,1-2H3,(H,32,36,37)/t26-,28+,41?/m0/s1

Synonyms: ((2S,6R)-6-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-tritylmorpholin-2-yl)methyl dimethylphosphoramidochloridate; [(2S,6R)-6-(3,4-Dihydro-2,4-dioxo-1(2H)-pyrimidinyl)-4-(triphenylmethyl)-2-morpholinyl]methyl N,N-dimethylphosphoramidochloridate; Morpholino U

O6-(p-tolyl pivalate)-N2-PhAc protected G PMO Monomer

Description: O6-(p-tolyl pivalate)-N2-PhAc protected G PMO Monomer is a modified guanosine (G) monomer used in the synthesis of peptide-conjugated morpholino oligomers (PMO). It features a pivaloyloxymethyl (p-tolyl pivalate) group at the O6 position and a phenylacetyl (PhAc) group at the N2 position, providing protection to the guanine base during oligomer synthesis. PMOs are synthetic nucleic acid analogs designed for antisense therapy and gene expression modulation. These monomers are incorporated into PMOs to specifically target and bind complementary RNA sequences, thereby interfering with gene expression or splicing mechanisms.

CAT: BRP-00596

CAS: 1155309-89-9

MF: C51H53ClN7O7P

MF: 942.44

Purity: ≥98%

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Density: 1.29±0.1 g/cm3

InChIKey: TXKNJPOHRYJGGF-UHFFFAOYSA-N

CanonicalSMILES: CC(C)(C)C(=O)OC1=CC=C(C=C1)COC2=NC(=NC3=C2N=CN3C4CN(CC(O4)COP(=O)(N(C)C)Cl)C(C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7)NC(=O)CC8=CC=CC=C8

IUPAC Name: [4-[[9-[6-[[chloro(dimethylamino)phosphoryl]oxymethyl]-4-tritylmorpholin-2-yl]-2-[(2-phenylacetyl)amino]purin-6-yl]oxymethyl]phenyl] 2,2-dimethylpropanoate

InChI: InChI=1S/C51H53ClN7O7P/c1-50(2,3)48(61)66-41-28-26-37(27-29-41)33-63-47-45-46(55-49(56-47)54-43(60)30-36-18-10-6-11-19-36)59(35-53-45)44-32-58(31-42(65-44)34-64-67(52,62)57(4)5)51(38-20-12-7-13-21-38,39-22-14-8-15-23-39)40-24-16-9-17-25-40/h6-29,35,42,44H,30-34H2,1-5H3,(H,54,55,56,60)

Synonyms: Propanoic acid, 2,2-dimethyl-, 4-[[[9-[6-[[[chloro(dimethylamino)phosphinyl]oxy]methyl]-4-(triphenylmethyl)-2-morpholinyl]-2-[(2-phenylacetyl)amino]-9H-purin-6-yl]oxy]methyl]phenyl ester; Activated DPG Subunit; 4-[[[9-[6-[[[Chloro(dimethylamino)phosphinyl]oxy]methyl]-4-(triphenylmethyl)-2-morpholinyl]-2-[(2-phenylacetyl)amino]-9H-purin-6-yl]oxy]methyl]phenyl 2,2-dimethylpropanoate; PMO G(PhAc) Phosphoramidite

4-(((9-((2R,6S)-6-(((Chloro(dimethylamino)phosphoryl)oxy)methyl)-4-tritylmorpholin-2-yl)-2-(2-phenylacetamido)-9H-purin-6-yl)oxy)methyl)phenyl pivalate

Description: 4-(((9-((2R,6S)-6-(((Chloro(dimethylamino)phosphoryl)oxy)methyl)-4-tritylmorpholin-2-yl)-2-(2-phenylacetamido)-9H-purin-6-yl)oxy)methyl)phenyl pivalate is a complex molecular structure used in oligonucleotide synthesis. This structure likely serves as a protecting group or linker in the synthesis of nucleic acid analogs, enabling the controlled assembly of oligonucleotide sequences. The compound's design incorporates functionalities for efficient coupling reactions and protection of sensitive chemical groups during solid-phase synthesis.

CAT: BRP-00597

CAS: 1044241-66-8

MF: C51H53ClN7O7P

MF: 942.44

Purity: ≥98%

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Density: 1.29±0.1 g/cm3

InChIKey: TXKNJPOHRYJGGF-OHCUOHFYSA-N

CanonicalSMILES: CC(C)(C)C(=O)OC1=CC=C(C=C1)COC2=NC(=NC3=C2N=CN3C4CN(CC(O4)COP(=O)(N(C)C)Cl)C(C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7)NC(=O)CC8=CC=CC=C8

IUPAC Name: [4-[[9-[(2R,6S)-6-[[chloro(dimethylamino)phosphoryl]oxymethyl]-4-tritylmorpholin-2-yl]-2-[(2-phenylacetyl)amino]purin-6-yl]oxymethyl]phenyl] 2,2-dimethylpropanoate

Synonyms: Propanoic acid, 2,2-dimethyl-, 4-[[[9-[(2R,6S)-6-[[[chloro(dimethylamino)phosphinyl]oxy]methyl]-4-(triphenylmethyl)-2-morpholinyl]-2-[(2-phenylacetyl)amino]-9H-purin-6-yl]oxy]methyl]phenyl ester; 4-[[[9-[(2R,6S)-6-[[[Chloro(dimethylamino)phosphinyl]oxy]methyl]-4-(triphenylmethyl)-2-morpholinyl]-2-[(2-phenylacetyl)amino]-9H-purin-6-yl]oxy]methyl]phenyl 2,2-dimethylpropanoate; O6-(p-tolyl pivalate)-N2-PhAc protected G PMO Monomer

DMTr-2'-O-4'-C-ethylene-rU-3'-CE-Phosphoramidite

Description: DMTr-2'-O-4'-C-ethylene-rU-3'-CE-Phosphoramidite, utilized in oligonucleotide synthesis, exhibits increased stability and binding properties owing to the incorporation of an ethylene linker at the 2'-O and 4'-C positions of uridine (rU). The presence of a cyanoethyl (CE) group at the 3'-end facilitates efficient coupling reactions during solid-phase synthesis. It is particularly useful in the generation of modified RNA molecules for various biological applications, such as RNA interference (RNAi) and antisense therapy.

CAT: BRP-00598

CAS: 287737-49-9

MF: C41H49N4O9P

MF: 772.84

Purity: ≥98%

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InChIKey: WGXJDXATSZPKMD-JOFAAVELSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C2C(OC1(CCO2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)N6C=CC(=O)NC6=O

IUPAC Name: 3-[[(1R,5R,7R,8S)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-7-(2,4-dioxopyrimidin-1-yl)-2,6-dioxabicyclo[3.2.1]octan-8-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C41H49N4O9P/c1-28(2)45(29(3)4)55(52-25-10-23-42)54-37-36-38(44-24-21-35(46)43-39(44)47)53-40(37,22-26-50-36)27-51-41(30-11-8-7-9-12-30,31-13-17-33(48-5)18-14-31)32-15-19-34(49-6)20-16-32/h7-9,11-21,24,28-29,36-38H,10,22,25-27H2,1-6H3,(H,43,46,47)/t36-,37+,38-,40-,55?/m1/s1

Synonyms: 2,4(1H,3H)-Pyrimidinedione, 1-[2,6-anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-5-deoxy-α-L-lyxo-hexofuranosyl]-; 1-[2,6-Anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-5-deoxy-α-L-lyxo-hexofuranosyl]-2,4(1H,3H)-pyrimidinedione; ENA-U Phosphoramidite

DMTr-2'-O-4'-C-ethylene-rC(Bz)-3'-CE-Phosphoramidite

Description: DMTr-2'-O-4'-C-ethylene-rC(Bz)-3'-CE-Phosphoramidite, employed in oligonucleotide synthesis, features an ethylene linker at the 2'-O and 4'-C positions of cytidine (rC), along with benzoyl (Bz) protection on the cytosine amino group. The cyanoethyl (CE) group at the 3'-end facilitates efficient coupling reactions during solid-phase synthesis. This modified nucleotide finds application in the creation of RNA sequences with enhanced stability and binding affinity, suitable for gene silencing studies and RNA-based therapeutics.

CAT: BRP-00599

CAS: 287737-36-4

MF: C48H54N5O9P

MF: 875.96

Purity: ≥98%

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InChIKey: IZEZSKXQKDNBEX-HAUVADMLSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C2C(OC1(CCO2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)N6C=CC(=NC6=O)NC(=O)C7=CC=CC=C7

IUPAC Name: N-[1-[(1R,5R,7R,8S)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-8-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-2,6-dioxabicyclo[3.2.1]octan-7-yl]-2-oxopyrimidin-4-yl]benzamide

InChI: InChI=1S/C48H54N5O9P/c1-33(2)53(34(3)4)63(60-30-13-28-49)62-43-42-45(52-29-26-41(51-46(52)55)50-44(54)35-14-9-7-10-15-35)61-47(43,27-31-58-42)32-59-48(36-16-11-8-12-17-36,37-18-22-39(56-5)23-19-37)38-20-24-40(57-6)25-21-38/h7-12,14-26,29,33-34,42-43,45H,13,27,30-32H2,1-6H3,(H,50,51,54,55)/t42-,43+,45-,47-,63?/m1/s1

Synonyms: N-[1-[2,6-Anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-5-deoxy-α-L-lyxo-hexofuranosyl]-1,2-dihydro-2-oxo-4-pyrimidinyl]benzamide; (1R,5R,7R,8S)-7-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-2,6-dioxabicyclo[3.2.1]octan-8-yl (2-cyanoethyl) diisopropylphosphoramidite; ENA-C(Bz) Phosphoramidite

DMTr-2'-O-4'-C-ethylene-rA(Bz)-3'-CE-Phosphoramidite

Description: DMTr-2'-O-4'-C-ethylene-rA(Bz)-3'-CE-Phosphoramidite, used in oligonucleotide synthesis, contains an ethylene linker at the 2'-O and 4'-C positions of adenosine (rA), with benzoyl (Bz) protection on the adenine amino group. The cyanoethyl (CE) group at the 3'-end facilitates efficient coupling reactions during solid-phase synthesis. It is employed in the construction of RNA sequences with augmented stability and binding affinity, suitable for various research applications including RNA-targeted therapy and gene expression modulation.

CAT: BRP-00600

CAS: 287737-45-5

MF: C49H54N7O8P

MF: 899.99

Purity: ≥98%

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InChIKey: IUGJZRODLODQAN-QLRWGQFGSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C2C(OC1(CCO2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)N6C=NC7=C(N=CN=C76)NC(=O)C8=CC=CC=C8

IUPAC Name: N-[9-[(1R,5R,7R,8S)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-8-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-2,6-dioxabicyclo[3.2.1]octan-7-yl]purin-6-yl]benzamide

InChI: InChI=1S/C49H54N7O8P/c1-33(2)56(34(3)4)65(62-28-13-27-50)64-43-42-47(55-32-53-41-44(51-31-52-45(41)55)54-46(57)35-14-9-7-10-15-35)63-48(43,26-29-60-42)30-61-49(36-16-11-8-12-17-36,37-18-22-39(58-5)23-19-37)38-20-24-40(59-6)25-21-38/h7-12,14-25,31-34,42-43,47H,13,26,28-30H2,1-6H3,(H,51,52,54,57)/t42-,43+,47-,48-,65?/m1/s1

Synonyms: Benzamide, N-[9-[2,6-anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-5-deoxy-α-L-lyxo-hexofuranosyl]-9H-purin-6-yl]-; ENA-A(bz) Phosphoramidite; N-[9-[2,6-Anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-5-deoxy-α-L-lyxo-hexofuranosyl]-9H-purin-6-yl]benzamide