Phosphoramidites - RNA / BOC Sciences

Lipid Phosphoramidite

Description: Lipid Phosphoramidite is a phosphoramidite derivative used in solid-phase synthesis of lipid-modified oligonucleotides. It contains a lipid moiety attached to a phosphoramidite backbone, facilitating the conjugation of oligonucleotides with lipids for applications such as drug delivery and gene silencing.

CAT: BRP-00771

CAS: 207273-85-6

MF: C48H95N4O4P

MF: 823.27

Purity: ≥95%

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InChIKey: GXAMBDAWMKUULA-UHFFFAOYSA-N

CanonicalSMILES: CCCCCCCCCCCCCCCCCC(=O)NCC(CNC(=O)CCCCCCCCCCCCCCCCC)OP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: N-[2-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-(octadecanoylamino)propyl]octadecanamide

InChI: InChI=1S/C48H95N4O4P/c1-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-38-47(53)50-42-46(56-57(55-41-37-40-49)52(44(3)4)45(5)6)43-51-48(54)39-36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-2/h44-46H,7-39,41-43H2,1-6H3,(H,50,53)(H,51,54)

Synonyms: Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl 2-[(1-oxooctadecyl)amino]-1-[[(1-oxooctadecyl)amino]methyl]ethyl ester; 2-cyanoethyl (1,3-distearamidopropan-2-yl) diisopropylphosphoramidite; 2-Cyanoethyl 2-[(1-oxooctadecyl)amino]-1-[[(1-oxooctadecyl)amino]methyl]ethyl N,N-bis(1-methylethyl)phosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, 2-cyanoethyl 2-[(1-oxooctadecyl)amino]-1-[[(1-oxooctadecyl)amino]methyl]ethyl ester

Biotin (BB) CED phosphoramidite

Description: Biotin (BB) CED phosphoramidite is a phosphoramidite derivative used for the synthesis of biotinylated oligonucleotides. It contains a biotin moiety attached to a phosphoramidite backbone, enabling the specific labeling and purification of nucleic acids using biotin-streptavidin affinity methods.

CAT: BRP-00772

MF: C57H76N5O9PS

MF: 1038.28

Purity: ≥97% by HPLC

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InChIKey: YMYNFOUBKWAXFH-YRZSEFLFSA-N

IUPAC Name: 1-(bis(4-methoxyphenyl)(phenyl)methoxy)-3-(3-(5-((3aS,4S,6aR)-1-(4-(tert-butyl)benzoyl)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)propoxy)propan-2-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C57H76N5O9PS/c1-40(2)62(41(3)4)72(70-36-15-33-58)71-49(38-69-57(44-17-11-10-12-18-44,45-25-29-47(66-8)30-26-45)46-27-31-48(67-9)32-28-46)37-68-35-16-34-59-52(63)20-14-13-19-51-53-50(39-73-51)61(55(65)60-53)54(64)42-21-23-43(24-22-42)56(5,6)7/h10-12,17-18,21-32,40-41,49-51,53H,13-16,19-20,34-39H2,1-9H3,(H,59,63)(H,60,65)/t49?,50-,51-,53-,72?/m0/s1

Synonyms: Biotin (BB)TM Phosphoramidite

12-(Trifluoroacetylamino)-hexyl-(2-cyanoethyl)-(N,N-diisopropyl)-phosphoramidite

Description: 12-(Trifluoroacetylamino)-hexyl-(2-cyanoethyl)-(N,N-diisopropyl)-phosphoramidite is a phosphoramidite derivative used in oligonucleotide synthesis. It contains a hexyl chain modified with a trifluoroacetyl group and a cyanoethyl protecting group attached to a phosphoramidite backbone, facilitating efficient coupling reactions during solid-phase synthesis.

CAT: BRP-00773

CAS: 2087458-61-3

MF: C23H43F3N3O3P

MF: 497.58

Purity: ≥95%

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InChIKey: UOXSQLQMSFUIRH-UHFFFAOYSA-N

CanonicalSMILES: N#CCCOP(OCCCCCCCCCCCCNC(=O)C(F)(F)F)N(C(C)C)C(C)C

IUPAC Name: 2-cyanoethyl (12-(2,2,2-trifluoroacetamido)dodecyl) diisopropylphosphoramidite

InChI: InChI=1S/C23H43F3N3O3P/c1-20(2)29(21(3)4)33(32-19-15-16-27)31-18-14-12-10-8-6-5-7-9-11-13-17-28-22(30)23(24,25)26/h20-21H,5-15,17-19H2,1-4H3,(H,28,30)

Synonyms: 5'-Amino-Modifier C12-TFA phosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl 12-[(2,2,2-trifluoroacetyl)amino]dodecyl ester; 2-Cyanoethyl 12-[(2,2,2-trifluoroacetyl)amino]dodecyl N,N-bis(1-methylethyl)phosphoramidite; TFA-Amino C-12 CED phosphoramidite; 5'-Amino-Modifier C12-TFA

GalNAc-Cluster-HHA-CE Phosphoramidite

Description: GalNAc-Cluster-HHA-CE Phosphoramidite is a specialized compound utilized in oligonucleotide synthesis. It contains N-acetylgalactosamine clusters and a glycan-binding unit (HHA-CE), enabling the study of glycan-protein interactions, crucial in glycobiology and drug development.

CAT: BRP-00784

CAS: 2550328-16-8

MF: C93H155N10O43P

MF: 2132.24

Purity: ≥98%

Appearance: White solid

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Storage: Store at 2-8 °C

InChIKey: YBEYXGGMLIQBIC-AKUCVXOZSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCCCCCNC(=O)C(CCCCNC(=O)COCCOCCOCCOC1C(C(C(C(O1)COC(=O)C)OC(=O)C)OC(=O)C)NC(=O)C)NC(=O)C(CCCCNC(=O)COCCOCCOCCOC2C(C(C(C(O2)COC(=O)C)OC(=O)C)OC(=O)C)NC(=O)C)NC(=O)COCCOCCOCCOC3C(C(C(C(O3)COC(=O)C)OC(=O)C)OC(=O)C)NC(=O)C)OCCC#N

IUPAC Name: [(2R,3R,4R,5R,6R)-5-acetamido-6-[2-[2-[2-[2-[[(5S)-5-[[2-[2-[2-[2-[(2R,3R,4R,5R,6R)-3-acetamido-4,5-diacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxyethoxy]ethoxy]ethoxy]acetyl]amino]-6-[[(2R)-6-[[2-[2-[2-[2-[(2R,3R,4R,5R,6R)-3-acetamido-4,5-diacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxyethoxy]ethoxy]ethoxy]acetyl]amino]-1-[6-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyhexylamino]-1-oxohexan-2-yl]amino]-6-oxohexyl]amino]-2-oxoethoxy]ethoxy]ethoxy]ethoxy]-3,4-diacetyloxyoxan-2-yl]methyl acetate

InChI: InChI=1S/C93H155N10O43P/c1-58(2)103(59(3)4)147(137-33-25-28-94)136-32-24-18-17-21-31-97-89(119)72(26-19-22-29-95-77(116)55-127-43-40-121-34-37-124-46-49-130-91-80(98-60(5)104)86(141-69(14)113)83(138-66(11)110)74(144-91)52-133-63(8)107)102-90(120)73(101-79(118)57-129-45-42-123-36-39-126-48-51-132-93-82(100-62(7)106)88(143-71(16)115)85(140-68(13)112)76(146-93)54-135-65(10)109)27-20-23-30-96-78(117)56-128-44-41-122-35-38-125-47-50-131-92-81(99-61(6)105)87(142-70(15)114)84(139-67(12)111)75(145-92)53-134-64(9)108/h58-59,72-76,80-88,91-93H,17-27,29-57H2,1-16H3,(H,95,116)(H,96,117)(H,97,119)(H,98,104)(H,99,105)(H,100,106)(H,101,118)(H,102,120)/t72-,73+,74-,75-,76-,80-,81-,82-,83+,84+,85+,86-,87-,88-,91-,92-,93-,147?/m1/s1

DMT-LNA-5mC phosphoramidite

Description: DMT-LNA-5mC phosphoramidite is a modified phosphoramidite used in the synthesis of Locked Nucleic Acid (LNA) oligonucleotides. It features a 5-methylcytosine (5mC) base, a DMT (dimethoxytrityl) protecting group, and a phosphoramidite group. This modification increases the thermal stability and binding affinity of the oligonucleotide, making it useful in antisense therapy, siRNA development, and molecular biology techniques.

CAT: BRP-00811

CAS: 1184723-53-2

MF: C41H50N5O8P

MF: 771.84

Purity: 98%

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Storage: Store at 2-8 °C, stored under nitrogen

InChIKey: UJUKPCINNDKWEN-ZRCIEBSPSA-N

CanonicalSMILES: CC1=CN(C(=O)N=C1N)C2C3C(C(O2)(CO3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: 3-[[(1R,3R,4R,7S)-3-(4-amino-5-methyl-2-oxopyrimidin-1-yl)-1-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-2,5-dioxabicyclo[2.2.1]heptan-7-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C41H50N5O8P/c1-27(2)46(28(3)4)55(52-23-11-22-42)54-36-35-38(45-24-29(5)37(43)44-39(45)47)53-40(36,25-50-35)26-51-41(30-12-9-8-10-13-30,31-14-18-33(48-6)19-15-31)32-16-20-34(49-7)21-17-32/h8-10,12-21,24,27-28,35-36,38H,11,23,25-26H2,1-7H3,(H2,43,44,47)/t35-,36+,38-,40-,55?/m1/s1

Synonyms: LNA-5-Me-C-CE Phosphoramidite; DMT-LNA-5mA phosphoramidite; 2(1H)-Pyrimidinone, 4-amino-1-[2,5-anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-α-L-lyxofuranosyl]-5-methyl-; 4-Amino-1-[2,5-anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-α-L-lyxofuranosyl]-5-methyl-2(1H)-pyrimidinone

DMT-LNA-G phosphoramidite

Description: DMT-LNA-G phosphoramidite is a modified phosphoramidite used in oligonucleotide synthesis, specifically for Locked Nucleic Acid (LNA) oligonucleotides. It contains a guanosine base modified with Locked Nucleic Acid (LNA) chemistry and a DMT (dimethoxytrityl) protecting group. This modification enhances the stability and binding affinity of the oligonucleotide to its complementary DNA or RNA strand. DMT-LNA-G phosphoramidite is commonly used in applications such as antisense therapy, PCR, and molecular diagnostics, where increased specificity and stability are required.

CAT: BRP-00812

CAS: 207131-17-7

MF: C41H48N7O8P

MF: 797.84

Purity: 98%

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Storage: Store at 2-8 °C, stored under nitrogen

InChIKey: FWLGFXLWSNDRLS-NVONNAQSSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C2C(OC1(CO2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)N6C=NC7=C6N=C(NC7=O)N

IUPAC Name: 3-[[(1R,3R,4R,7S)-3-(2-amino-6-oxo-1H-purin-9-yl)-1-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-2,5-dioxabicyclo[2.2.1]heptan-7-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C41H48N7O8P/c1-26(2)48(27(3)4)57(54-22-10-21-42)56-35-34-38(47-25-44-33-36(47)45-39(43)46-37(33)49)55-40(35,23-52-34)24-53-41(28-11-8-7-9-12-28,29-13-17-31(50-5)18-14-29)30-15-19-32(51-6)20-16-30/h7-9,11-20,25-27,34-35,38H,10,22-24H2,1-6H3,(H3,43,45,46,49)/t34-,35+,38-,40-,57?/m1/s1

Synonyms: Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O,4'-C-methylene-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; (1R,3R,4R,7S)-3-(2-Amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-1-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-2,5-dioxabicyclo[2.2.1]heptan-7-yl (2-cyanoethyl) diisopropylphosphoramidite

LNA A(pac) amidite

Description: LNA A(pac) amidite is a modified phosphoramidite used in oligonucleotide synthesis, specifically for incorporating Locked Nucleic Acid (LNA) modifications into nucleic acid sequences. This modification involves attaching a phenoxyacetyl (pac) group to the adenine base of LNA. It is commonly used to enhance the binding affinity, stability, and specificity of oligonucleotides in various applications such as antisense therapy, PCR, and molecular diagnostics.

CAT: BRP-00813

MF: C49H54N7O9P

MF: 915.98

Purity: >98%

Appearance: Off-white solid

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Storage: Store at -20 °C

InChIKey: RHUYJRYFCPQBIE-LXTWGDFWSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (1R,3R,4R,7S)-1-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-(6-(2-phenoxyacetamido)-9H-purin-9-yl)-2,5-dioxabicyclo[2.2.1]heptan-7-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C49H54N7O9P/c1-33(2)56(34(3)4)66(63-27-13-26-50)65-44-43-47(55-32-53-42-45(51-31-52-46(42)55)54-41(57)28-60-40-16-11-8-12-17-40)64-48(44,29-61-43)30-62-49(35-14-9-7-10-15-35,36-18-22-38(58-5)23-19-36)37-20-24-39(59-6)25-21-37/h7-12,14-25,31-34,43-44,47H,13,27-30H2,1-6H3,(H,51,52,54,57)/t43-,44+,47-,48-,66?/m1/s1

Synonyms: LNA A(pac) CE-Phosphoramidite; DMTr-LNA-A(pac)-3-CED-phosphoramidite

2'-OTFM U amidite

Description: 2'-OTFM U amidite is a modified phosphoramidite used in oligonucleotide synthesis, particularly for introducing 2'-O-trifluoromethyl (OTFM) modifications into RNA sequences. This modification involves adding a trifluoromethyl group to the 2'-position of uridine. It is utilized to enhance the stability and specificity of RNA molecules in various applications such as RNA interference, antisense therapy, and RNA structural studies.

CAT: BRP-00814

CAS: 869734-94-1

MF: C40H46F3N4O9P

MF: 814.79

Purity: >95%

Appearance: Off-white solid

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Storage: Store at -20 °C

InChIKey: AIVSTWHGYKADBY-FNMBQTMFSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OC(F)(F)F)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(2,4-dioxopyrimidin-1-yl)-4-(trifluoromethoxy)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C40H46F3N4O9P/c1-26(2)47(27(3)4)57(53-24-10-22-44)56-35-33(54-37(36(35)55-40(41,42)43)46-23-21-34(48)45-38(46)49)25-52-39(28-11-8-7-9-12-28,29-13-17-31(50-5)18-14-29)30-15-19-32(51-6)20-16-30/h7-9,11-21,23,26-27,33,35-37H,10,24-25H2,1-6H3,(H,45,48,49)/t33-,35-,36-,37-,57?/m1/s1

Synonyms: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(trifluoromethyl)-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-(trifluoromethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

LNA G(iPr-pac) amidite

Description: LNA G(iPr-pac) amidite is a modified phosphoramidite used in oligonucleotide synthesis, specifically for incorporating Locked Nucleic Acid (LNA) modifications into nucleic acid sequences. This modification involves attaching an isopropylphenoxyacetyl (iPr-pac) group to the guanine base of LNA. It is commonly used to enhance the stability, specificity, and binding affinity of oligonucleotides in various applications such as antisense therapy, PCR, and molecular diagnostics.

CAT: BRP-00815

MF: C52H60N7O10P

MF: 974.06

Purity: >95%

Appearance: Off-white solid

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Storage: Store at -20 °C

InChIKey: FSLCFYFCVYNCAE-ZVOKJCSSSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (1R,3R,4R,7S)-1-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-(2-(2-(4-isopropylphenoxy)acetamido)-6-oxo-1,6-dihydro-9H-purin-9-yl)-2,5-dioxabicyclo[2.2.1]heptan-7-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C52H60N7O10P/c1-33(2)36-15-21-42(22-16-36)64-29-43(60)55-50-56-47-44(48(61)57-50)54-32-58(47)49-45-46(69-70(67-28-12-27-53)59(34(3)4)35(5)6)51(68-49,30-65-45)31-66-52(37-13-10-9-11-14-37,38-17-23-40(62-7)24-18-38)39-19-25-41(63-8)26-20-39/h9-11,13-26,32-35,45-46,49H,12,28-31H2,1-8H3,(H2,55,56,57,60,61)/t45-,46+,49-,51-,70?/m1/s1

Synonyms: LNA G(iPr-pac) CE-Phosphoramidite; DMTr-LNA-G(iPr-pac)-3-CED-phosphoramidite

2'-OTFM C(Ac) amidite

Description: 2'-OTFM C(Ac) amidite is a modified phosphoramidite used in oligonucleotide synthesis to introduce 2'-O-trifluoromethyl (OTFM) modifications into RNA sequences, specifically targeting cytidine (C). This modification involves adding a trifluoromethyl group to the 2'-position of cytidine and acetylating the amino group of cytidine. It enhances the stability and specificity of RNA molecules and is commonly used in applications such as RNA interference, antisense therapy, and RNA structural studies.

CAT: BRP-00816

CAS: 869734-91-8

MF: C42H49F3N5O9P

MF: 855.85

Purity: >95%

Appearance: Off-white solid

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Storage: Store at -20 °C

InChIKey: VECFWZPFXRVLKY-HCIBFWJXSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OC(F)(F)F)N2C=CC(=NC2=O)NC(=O)C)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-(trifluoromethoxy)oxolan-2-yl]-2-oxopyrimidin-4-yl]acetamide

InChI: InChI=1S/C42H49F3N5O9P/c1-27(2)50(28(3)4)60(56-25-11-23-46)59-37-35(57-39(38(37)58-42(43,44)45)49-24-22-36(47-29(5)51)48-40(49)52)26-55-41(30-12-9-8-10-13-30,31-14-18-33(53-6)19-15-31)32-16-20-34(54-7)21-17-32/h8-10,12-22,24,27-28,35,37-39H,11,25-26H2,1-7H3,(H,47,48,51,52)/t35-,37-,38-,39-,60?/m1/s1

Synonyms: Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(trifluoromethyl)-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; (2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(trifluoromethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; 2'-OTFM C(Ac) CE-Phosphoramidite

2'-OTFM C(Bz) amidite

Description: 2'-OTFM C(Bz) amidite is a modified phosphoramidite used in oligonucleotide synthesis to introduce 2'-O-trifluoromethyl (OTFM) modifications into RNA sequences, specifically targeting cytidine (C). This modification involves adding a trifluoromethyl group to the 2'-position of cytidine and benzoylating the amino group of cytidine. It enhances the stability and specificity of RNA molecules and is commonly used in applications such as RNA interference, antisense therapy, and RNA structural studies.

CAT: BRP-00817

MF: C47H51F3N5O9P

MF: 917.92

Purity: >95%

Appearance: Off-white solid

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Storage: Store at -20 °C

InChIKey: APWVCZQYEKTHIH-WKNHZCODSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(trifluoromethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C47H51F3N5O9P/c1-31(2)55(32(3)4)65(61-29-13-27-51)64-41-39(62-44(42(41)63-47(48,49)50)54-28-26-40(53-45(54)57)52-43(56)33-14-9-7-10-15-33)30-60-46(34-16-11-8-12-17-34,35-18-22-37(58-5)23-19-35)36-20-24-38(59-6)25-21-36/h7-12,14-26,28,31-32,39,41-42,44H,13,29-30H2,1-6H3,(H,52,53,56,57)/t39-,41-,42-,44-,65?/m1/s1

Synonyms: 2'-OTFM C(Bz) CE-Phosphoramidite

2'-OTFM G(iBu) amidite

Description: 2'-OTFM G(iBu) amidite is a modified phosphoramidite used in oligonucleotide synthesis to introduce 2'-O-trifluoromethyl (OTFM) modifications into RNA sequences, specifically targeting guanosine (G). This modification involves adding a trifluoromethyl group to the 2'-position of guanosine and attaching an isobutyl (iBu) group to the exocyclic amine of guanosine. It enhances the stability and specificity of RNA molecules and is commonly used in applications such as RNA interference, antisense therapy, and RNA structural studies.

CAT: BRP-00818

MF: C45H53F3N7O9P

MF: 923.93

Purity: >95%

Appearance: Off-white solid

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Storage: Store at -20 °C

InChIKey: YINYCQLAYPBOSI-SDLFASLNSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N(C(C)C)C(C)C)OCCC#N)OC(F)(F)F

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-(trifluoromethoxy)oxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide

InChI: InChI=1S/C45H53F3N7O9P/c1-27(2)40(56)52-43-51-39-36(41(57)53-43)50-26-54(39)42-38(63-45(46,47)48)37(64-65(61-24-12-23-49)55(28(3)4)29(5)6)35(62-42)25-60-44(30-13-10-9-11-14-30,31-15-19-33(58-7)20-16-31)32-17-21-34(59-8)22-18-32/h9-11,13-22,26-29,35,37-38,42H,12,24-25H2,1-8H3,(H2,51,52,53,56,57)/t35-,37-,38-,42-,65?/m1/s1

Synonyms: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(trifluoromethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; 2'-OTFM G(iBu) CE-Phosphoramidite

2'-OMe C(Ac) Me-amidite

Description: 2'-OMe C(Ac) Me-amidite is a modified phosphoramidite used in oligonucleotide synthesis, particularly for introducing 2'-O-methyl (2'-OMe) modifications into RNA sequences, specifically targeting cytidine (C). This modification involves adding a methyl group to the 2'-position of cytidine and acetylating the amino group of cytidine. It enhances the stability and specificity of RNA molecules and is commonly used in applications such as RNA interference, antisense therapy, and RNA structural studies.

CAT: BRP-00821

CAS: 205116-62-7

MF: C40H51N4O8P

MF: 746.84

Purity: >95%

Appearance: Off-white solid

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InChIKey: QRMLMMQHOYHYLD-GFIGKZKCSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: O=C1N=C(C=CN1C2OC(COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)C(OP(N(C(C)C)C(C)C)C)C2OC)NC(=O)C

IUPAC Name: N-(1-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((diisopropylamino)(methyl)phosphaneyl)oxy)-3-methoxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide

InChI: InChI=1S/C40H51N4O8P/c1-26(2)44(27(3)4)53(9)52-36-34(51-38(37(36)49-8)43-24-23-35(41-28(5)45)42-39(43)46)25-50-40(29-13-11-10-12-14-29,30-15-19-32(47-6)20-16-30)31-17-21-33(48-7)22-18-31/h10-24,26-27,34,36-38H,25H2,1-9H3,(H,41,42,45,46)/t34-,36-,37-,38-,53?/m1/s1

Synonyms: Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[P-methyl-N,N-bis(1-methylethyl)phosphonamidite]; 5'-O-DMTr-2'-OMe-C(Ac)-3'-O-[P-methyl-(N,N-diisopropyl)]-Phosphoramidite; N4-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-OMe-C-3'-O-[P-methyl-(N,N-diisopropyl)]-Phosphoramidite; 2'-O-Methyl Cytidine (n-acetyl) p-methyl phosphonamidite; 5'-O-DMTr-2'-OMe-C(Ac) methyl phosphonamidite

2'-OMe A(Bz) Me-amidite

Description: 2'-OMe A(Bz) Me-amidite is a modified phosphoramidite used in oligonucleotide synthesis to introduce 2'-O-methyl (2'-OMe) modifications into RNA sequences, specifically targeting adenosine (A). This modification involves adding a methyl group to the 2'-position of adenosine and benzoylating the amino group of adenosine. It enhances the stability and specificity of RNA molecules and is commonly used in applications such as RNA interference, antisense therapy, and RNA structural studies.

CAT: BRP-00822

CAS: 158691-23-7

MF: C46H53N6O7P

MF: 832.94

Purity: >95%

Appearance: Off-white solid

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InChIKey: GICXOURJNDWAPG-NSWJMSGMSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: O=C(NC1=NC=NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP(N(C(C)C)C(C)C)C)C3OC)C=7C=CC=CC7

IUPAC Name: N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((diisopropylamino)(methyl)phosphaneyl)oxy)-3-methoxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide

InChI: InChI=1S/C46H53N6O7P/c1-30(2)52(31(3)4)60(8)59-40-38(58-45(41(40)56-7)51-29-49-39-42(47-28-48-43(39)51)50-44(53)32-15-11-9-12-16-32)27-57-46(33-17-13-10-14-18-33,34-19-23-36(54-5)24-20-34)35-21-25-37(55-6)26-22-35/h9-26,28-31,38,40-41,45H,27H2,1-8H3,(H,47,48,50,53)/t38-,40-,41-,45-,60?/m1/s1

Synonyms: Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[P-methyl-N,N-bis(1-methylethyl)phosphonamidite]; 5'-O-DMTr-2'-OMe-A(Bz)-3'-O-[P-methyl-(N,N-diisopropyl)]-Phosphoramidite; N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-OMe-adenosine-3'-O-[P-methyl-(N,N-diisopropyl)]-Phosphoramidite; 2'-O-Methyl Adenosine (n-bz) p-methyl phosphonamidite; 5'-O-DMTr-2'-OMe-A(Bz) methyl phosphonamidite

2'-OMe G(iBu) Me-amidite

Description: 2'-OMe G(iBu) Me-amidite is a modified phosphoramidite used in oligonucleotide synthesis to introduce 2'-O-methyl (2'-OMe) modifications into RNA sequences, specifically targeting guanosine (G). This modification involves adding a methyl group to the 2'-position of guanosine and attaching an isobutyl (iBu) group to the exocyclic amine of guanosine. It enhances the stability and specificity of RNA molecules and is commonly used in applications such as RNA interference, antisense therapy, and RNA structural studies.

CAT: BRP-00823

CAS: 191786-63-7

MF: C43H55N6O8P

MF: 814.92

Purity: >95%

Appearance: Off-white solid

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InChIKey: JAVHPGCWDJVLLN-BSQJSOGMSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: O=C1N=C(NC(=O)C(C)C)NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP(N(C(C)C)C(C)C)C)C3OC

IUPAC Name: N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((diisopropylamino)(methyl)phosphaneyl)oxy)-3-methoxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide

InChI: InChI=1S/C43H55N6O8P/c1-26(2)39(50)46-42-45-38-35(40(51)47-42)44-25-48(38)41-37(54-9)36(57-58(10)49(27(3)4)28(5)6)34(56-41)24-55-43(29-14-12-11-13-15-29,30-16-20-32(52-7)21-17-30)31-18-22-33(53-8)23-19-31/h11-23,25-28,34,36-37,41H,24H2,1-10H3,(H2,45,46,47,50,51)/t34-,36-,37-,41-,58?/m1/s1

Synonyms: Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-N-(2-methyl-1-oxopropyl)-, 3'-[P-methyl-N,N-bis(1-methylethyl)phosphonamidite]; 5'-O-DMTr-2'-OMe-G(iBu)-3'-O-[P-methyl-(N,N-diisopropyl)]-Phosphoramidite; N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-OMe-G-3'-O-[P-methyl-(N,N-diisopropyl)]-Phosphoramidite; 2'-O-Methyl Guanosine (n-ibu) p-methyl phosphonamidite; 5'-O-DMTr-2'-OMe-G(iBu) methyl phosphonamidite

MMTr C7 amine amidite

Description: MMTr C7 amine amidite is a linker phosphoramidite used in oligonucleotide synthesis. This compound serves as a linker during solid-phase oligonucleotide synthesis, allowing for the attachment of nucleotide building blocks to a growing oligonucleotide chain. MMTr C7 amine amidite plays a crucial role in the efficient and controlled synthesis of modified oligonucleotides for various applications in molecular biology and biotechnology.

CAT: BRP-00824

MF: C36H50N3O3P

MF: 603.79

Purity: >95%

Appearance: Light-yellow oily matter

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InChIKey: SESSADZGYXHMSJ-UHFFFAOYSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCCCCCCNC(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=C(C=C3)OC)OCCC#N

IUPAC Name: 3-[[di(propan-2-yl)amino]-[7-[[(4-methoxyphenyl)-diphenylmethyl]amino]heptoxy]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C36H50N3O3P/c1-30(2)39(31(3)4)43(42-29-17-26-37)41-28-16-8-6-7-15-27-38-36(32-18-11-9-12-19-32,33-20-13-10-14-21-33)34-22-24-35(40-5)25-23-34/h9-14,18-25,30-31,38H,6-8,15-17,27-29H2,1-5H3

Synonyms: 2-cyanoethyl (7-(((4-methoxyphenyl)diphenylmethyl)amino)heptyl) diisopropylphosphoramidite; NHMMTr-C7 Phosphoramidite; Monomethoxytrityl-heptylamine-linker Phosphoramidite

MMTr C5 amine amidite

Description: MMTr C5 amine amidite is a linker phosphoramidite used in oligonucleotide synthesis. This compound serves as a linker during solid-phase oligonucleotide synthesis, allowing the attachment of nucleotide building blocks to a growing oligonucleotide chain. MMTr C5 amine amidite plays a crucial role in the efficient and controlled synthesis of modified oligonucleotides for various applications in molecular biology and biotechnology.

CAT: BRP-00825

CAS: 178811-39-7

MF: C34H46N3O3P

MF: 575.73

Purity: >95%

Appearance: Light-yellow oily matter

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InChIKey: QKLNHYFSRTYCRA-UHFFFAOYSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OCCCCCNC(C1=CC=C(OC)C=C1)(C2=CC=CC=C2)C3=CC=CC=C3

IUPAC Name: 2-cyanoethyl (5-(((4-methoxyphenyl)diphenylmethyl)amino)pentyl) diisopropylphosphoramidite

InChI: InChI=1S/C34H46N3O3P/c1-28(2)37(29(3)4)41(40-27-15-24-35)39-26-14-8-13-25-36-34(30-16-9-6-10-17-30,31-18-11-7-12-19-31)32-20-22-33(38-5)23-21-32/h6-7,9-12,16-23,28-29,36H,8,13-15,25-27H2,1-5H3

Synonyms: NHMMTr-C5 Phosphoramidite; Monomethoxytrityl-pentylamine-linker Phosphoramidite

MMTr C4 amine amidite

Description: MMTr C4 amine amidite is a linker phosphoramidite used in oligonucleotide synthesis. This compound serves as a linker during solid-phase oligonucleotide synthesis, facilitating the attachment of nucleotide building blocks to a growing oligonucleotide chain. MMTr C4 amine amidite is essential for the controlled synthesis of modified oligonucleotides for various applications in molecular biology and biotechnology.

CAT: BRP-00826

CAS: 178811-38-6

MF: C33H44N3O3P

MF: 561.71

Purity: >95%

Appearance: Light-yellow oily matter

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InChIKey: LVYNYJLDPZLYCP-UHFFFAOYSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OCCCCNC(C1=CC=C(OC)C=C1)(C2=CC=CC=C2)C3=CC=CC=C3

IUPAC Name: 2-cyanoethyl (4-(((4-methoxyphenyl)diphenylmethyl)amino)butyl) diisopropylphosphoramidite

InChI: InChI=1S/C33H44N3O3P/c1-27(2)36(28(3)4)40(39-26-14-23-34)38-25-13-12-24-35-33(29-15-8-6-9-16-29,30-17-10-7-11-18-30)31-19-21-32(37-5)22-20-31/h6-11,15-22,27-28,35H,12-14,24-26H2,1-5H3

Synonyms: NHMMTr-C4 Phosphoramidite; Monomethoxytrityl-butylamine-linker Phosphoramidite

MMTr C2 amine amidite

Description: MMTr C2 amine amidite is a linker phosphoramidite used in oligonucleotide synthesis. This compound serves as a linker during solid-phase oligonucleotide synthesis, enabling the attachment of nucleotide building blocks to a growing oligonucleotide chain. MMTr C2 amine amidite is crucial for the controlled synthesis of modified oligonucleotides for various applications in molecular biology and biotechnology.

CAT: BRP-00827

MF: C31H40N3O3P

MF: 533.65

Purity: >95%

Appearance: Light-yellow oily matter

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InChIKey: TVYYYWLTEUUCSU-UHFFFAOYSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OCCNC(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=C(C=C3)OC

IUPAC Name: 3-[[di(propan-2-yl)amino]-[2-[[(4-methoxyphenyl)-diphenylmethyl]amino]ethoxy]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C31H40N3O3P/c1-25(2)34(26(3)4)38(36-23-12-21-32)37-24-22-33-31(27-13-8-6-9-14-27,28-15-10-7-11-16-28)29-17-19-30(35-5)20-18-29/h6-11,13-20,25-26,33H,12,22-24H2,1-5H3

Synonyms: 2-cyanoethyl (2-(((4-methoxyphenyl)diphenylmethyl)amino)ethyl) diisopropylphosphoramidite; MMTr C2 linker Phosphoramidite; MMT-ethylamine-linker Phosphoramidite; NHMMTr-C2 Phosphoramidite

2'-OTBS U OMe-amidite

Description: 2'-OTBS U OMe-amidite is a reagent used for synthesizing modified oligonucleotides. It has uridine with a 2'-tert-butyldimethylsilyl (TBDMS) protecting group, which enhances stability during the synthesis process. This modification improves the stability and resistance of the oligonucleotides to degradation.

CAT: BRP-00828

CAS: 114207-67-9

MF: C43H60N3O9PSi

MF: 822.03

Purity: >95%

Appearance: White, off-white to faint yellow powder

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InChIKey: AJKMTCZXJSDRLN-CYSIDSPMSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OC)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: 1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-[[di(propan-2-yl)amino]-methoxyphosphanyl]oxyoxolan-2-yl]pyrimidine-2,4-dione

InChI: InChI=1S/C43H60N3O9PSi/c1-29(2)46(30(3)4)56(51-10)54-38-36(53-40(45-27-26-37(47)44-41(45)48)39(38)55-57(11,12)42(5,6)7)28-52-43(31-16-14-13-15-17-31,32-18-22-34(49-8)23-19-32)33-20-24-35(50-9)25-21-33/h13-27,29-30,36,38-40H,28H2,1-12H3,(H,44,47,48)/t36-,38-,39-,40-,56?/m1/s1

Synonyms: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl methyl diisopropylphosphoramidite; 5'-O-DMTr-2'-O-TBDMS-U-3'-Methoxy-phosphoramidite; 5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyl-dimethylsilyl)-uridine-3'-Methoxy-phosphoramidite; 2'-tBDSilyl Uridine methyl phosphoramidite