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2'-Modified Phosphoramidites
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(97/97) PMO Phosphoramidates and Derivatives (33/33) PseudoUridine Phosphoramidite
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(82/82) Linker Phosphoramidites
(85/85) Other Phosphoramidites
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N-Trityl-N6-benzoyl-morpholino-A(Bz)-7'-O-phosphoramidite
Description: Morpholino nucleoside phosphoramidite monomer to make special oligonucleotides or modified RNA derivatives.
CAT: BRP-00766
CAS: 2434795-08-9
Molecular Formula: C45H49N8O4P
Molecular Weight: 796.90
Purity: ≥97% by HPLC
Appearance: White to off-white foam solid
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Storage: Store at -20 °C, under inert atmosphere
InChIKey: PKBMTUUGKIQWLB-SJMRETRVSA-N
Solubility: Soluble in Acetone, Chloroform, DMSO, Ethanol, Methanol
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OCC1CN(CC(O1)N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)C(C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7
IUPAC Name: N-[9-[(2R,6S)-6-[[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxymethyl]-4-tritylmorpholin-2-yl]purin-6-yl]benzamide
InChI: InChI=1S/C45H49N8O4P/c1-33(2)53(34(3)4)58(55-27-17-26-46)56-30-39-28-51(45(36-20-11-6-12-21-36,37-22-13-7-14-23-37)38-24-15-8-16-25-38)29-40(57-39)52-32-49-41-42(47-31-48-43(41)52)50-44(54)35-18-9-5-10-19-35/h5-16,18-25,31-34,39-40H,17,27-30H2,1-4H3,(H,47,48,50,54)/t39-,40+,58?/m0/s1
Synonyms: N-Trityl-N6-benzoyl-morpholino-A-5'-O-phosphoramidite; N-Trityl-N6-benzoyl-morpholino-A-7'-O-phosphoramidite; ((2S,6R)-6-(6-benzamido-9H-purin-9-yl)-4-tritylmorpholin-2-yl)methyl (2-cyanoethyl) diisopropylphosphoramidite
Lipid Phosphoramidite
Description: Lipid Phosphoramidite is a phosphoramidite derivative used in solid-phase synthesis of lipid-modified oligonucleotides. It contains a lipid moiety attached to a phosphoramidite backbone, facilitating the conjugation of oligonucleotides with lipids for applications such as drug delivery and gene silencing.
CAT: BRP-00771
CAS: 207273-85-6
Molecular Formula: C48H95N4O4P
Molecular Weight: 823.27
Purity: ≥95%
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InChIKey: GXAMBDAWMKUULA-UHFFFAOYSA-N
CanonicalSMILES: CCCCCCCCCCCCCCCCCC(=O)NCC(CNC(=O)CCCCCCCCCCCCCCCCC)OP(N(C(C)C)C(C)C)OCCC#N
IUPAC Name: N-[2-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-(octadecanoylamino)propyl]octadecanamide
InChI: InChI=1S/C48H95N4O4P/c1-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-38-47(53)50-42-46(56-57(55-41-37-40-49)52(44(3)4)45(5)6)43-51-48(54)39-36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-2/h44-46H,7-39,41-43H2,1-6H3,(H,50,53)(H,51,54)
Synonyms: Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl 2-[(1-oxooctadecyl)amino]-1-[[(1-oxooctadecyl)amino]methyl]ethyl ester; 2-cyanoethyl (1,3-distearamidopropan-2-yl) diisopropylphosphoramidite; 2-Cyanoethyl 2-[(1-oxooctadecyl)amino]-1-[[(1-oxooctadecyl)amino]methyl]ethyl N,N-bis(1-methylethyl)phosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, 2-cyanoethyl 2-[(1-oxooctadecyl)amino]-1-[[(1-oxooctadecyl)amino]methyl]ethyl ester
-ced-phosphoramidite.gif)
Biotin (BB) CED phosphoramidite
Description: Biotin (BB) CED phosphoramidite is a phosphoramidite derivative used for the synthesis of biotinylated oligonucleotides. It contains a biotin moiety attached to a phosphoramidite backbone, enabling the specific labeling and purification of nucleic acids using biotin-streptavidin affinity methods.
CAT: BRP-00772
Molecular Formula: C57H76N5O9PS
Molecular Weight: 1038.28
Purity: ≥97% by HPLC
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InChIKey: YMYNFOUBKWAXFH-YRZSEFLFSA-N
IUPAC Name: 1-(bis(4-methoxyphenyl)(phenyl)methoxy)-3-(3-(5-((3aS,4S,6aR)-1-(4-(tert-butyl)benzoyl)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)propoxy)propan-2-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C57H76N5O9PS/c1-40(2)62(41(3)4)72(70-36-15-33-58)71-49(38-69-57(44-17-11-10-12-18-44,45-25-29-47(66-8)30-26-45)46-27-31-48(67-9)32-28-46)37-68-35-16-34-59-52(63)20-14-13-19-51-53-50(39-73-51)61(55(65)60-53)54(64)42-21-23-43(24-22-42)56(5,6)7/h10-12,17-18,21-32,40-41,49-51,53H,13-16,19-20,34-39H2,1-9H3,(H,59,63)(H,60,65)/t49?,50-,51-,53-,72?/m0/s1
Synonyms: Biotin (BB)TM Phosphoramidite
12-(Trifluoroacetylamino)-hexyl-(2-cyanoethyl)-(N,N-diisopropyl)-phosphoramidite
Description: 12-(Trifluoroacetylamino)-hexyl-(2-cyanoethyl)-(N,N-diisopropyl)-phosphoramidite is a phosphoramidite derivative used in oligonucleotide synthesis. It contains a hexyl chain modified with a trifluoroacetyl group and a cyanoethyl protecting group attached to a phosphoramidite backbone, facilitating efficient coupling reactions during solid-phase synthesis.
CAT: BRP-00773
CAS: 2087458-61-3
Molecular Formula: C23H43F3N3O3P
Molecular Weight: 497.58
Purity: ≥95%
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InChIKey: UOXSQLQMSFUIRH-UHFFFAOYSA-N
CanonicalSMILES: N#CCCOP(OCCCCCCCCCCCCNC(=O)C(F)(F)F)N(C(C)C)C(C)C
IUPAC Name: 2-cyanoethyl (12-(2,2,2-trifluoroacetamido)dodecyl) diisopropylphosphoramidite
InChI: InChI=1S/C23H43F3N3O3P/c1-20(2)29(21(3)4)33(32-19-15-16-27)31-18-14-12-10-8-6-5-7-9-11-13-17-28-22(30)23(24,25)26/h20-21H,5-15,17-19H2,1-4H3,(H,28,30)
Synonyms: 5'-Amino-Modifier C12-TFA phosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl 12-[(2,2,2-trifluoroacetyl)amino]dodecyl ester; 2-Cyanoethyl 12-[(2,2,2-trifluoroacetyl)amino]dodecyl N,N-bis(1-methylethyl)phosphoramidite; TFA-Amino C-12 CED phosphoramidite; 5'-Amino-Modifier C12-TFA
GalNAc-Cluster-HHA-CE Phosphoramidite
Description: GalNAc-Cluster-HHA-CE Phosphoramidite is a specialized compound utilized in oligonucleotide synthesis. It contains N-acetylgalactosamine clusters and a glycan-binding unit (HHA-CE), enabling the study of glycan-protein interactions, crucial in glycobiology and drug development.
CAT: BRP-00784
CAS: 2550328-16-8
Molecular Formula: C93H155N10O43P
Molecular Weight: 2132.24
Purity: ≥98%
Appearance: White solid
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Storage: Store at 2-8 °C
InChIKey: YBEYXGGMLIQBIC-AKUCVXOZSA-N
CanonicalSMILES: CC(C)N(C(C)C)P(OCCCCCCNC(=O)C(CCCCNC(=O)COCCOCCOCCOC1C(C(C(C(O1)COC(=O)C)OC(=O)C)OC(=O)C)NC(=O)C)NC(=O)C(CCCCNC(=O)COCCOCCOCCOC2C(C(C(C(O2)COC(=O)C)OC(=O)C)OC(=O)C)NC(=O)C)NC(=O)COCCOCCOCCOC3C(C(C(C(O3)COC(=O)C)OC(=O)C)OC(=O)C)NC(=O)C)OCCC#N
IUPAC Name: [(2R,3R,4R,5R,6R)-5-acetamido-6-[2-[2-[2-[2-[[(5S)-5-[[2-[2-[2-[2-[(2R,3R,4R,5R,6R)-3-acetamido-4,5-diacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxyethoxy]ethoxy]ethoxy]acetyl]amino]-6-[[(2R)-6-[[2-[2-[2-[2-[(2R,3R,4R,5R,6R)-3-acetamido-4,5-diacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxyethoxy]ethoxy]ethoxy]acetyl]amino]-1-[6-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyhexylamino]-1-oxohexan-2-yl]amino]-6-oxohexyl]amino]-2-oxoethoxy]ethoxy]ethoxy]ethoxy]-3,4-diacetyloxyoxan-2-yl]methyl acetate
InChI: InChI=1S/C93H155N10O43P/c1-58(2)103(59(3)4)147(137-33-25-28-94)136-32-24-18-17-21-31-97-89(119)72(26-19-22-29-95-77(116)55-127-43-40-121-34-37-124-46-49-130-91-80(98-60(5)104)86(141-69(14)113)83(138-66(11)110)74(144-91)52-133-63(8)107)102-90(120)73(101-79(118)57-129-45-42-123-36-39-126-48-51-132-93-82(100-62(7)106)88(143-71(16)115)85(140-68(13)112)76(146-93)54-135-65(10)109)27-20-23-30-96-78(117)56-128-44-41-122-35-38-125-47-50-131-92-81(99-61(6)105)87(142-70(15)114)84(139-67(12)111)75(145-92)53-134-64(9)108/h58-59,72-76,80-88,91-93H,17-27,29-57H2,1-16H3,(H,95,116)(H,96,117)(H,97,119)(H,98,104)(H,99,105)(H,100,106)(H,101,118)(H,102,120)/t72-,73+,74-,75-,76-,80-,81-,82-,83+,84+,85+,86-,87-,88-,91-,92-,93-,147?/m1/s1
DMT-LNA-5mC phosphoramidite
Description: DMT-LNA-5mC phosphoramidite is a modified phosphoramidite used in the synthesis of Locked Nucleic Acid (LNA) oligonucleotides. It features a 5-methylcytosine (5mC) base, a DMT (dimethoxytrityl) protecting group, and a phosphoramidite group. This modification increases the thermal stability and binding affinity of the oligonucleotide, making it useful in antisense therapy, siRNA development, and molecular biology techniques.
CAT: BRP-00811
CAS: 1184723-53-2
Molecular Formula: C41H50N5O8P
Molecular Weight: 771.84
Purity: 98%
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Storage: Store at 2-8 °C, stored under nitrogen
InChIKey: UJUKPCINNDKWEN-ZRCIEBSPSA-N
CanonicalSMILES: CC1=CN(C(=O)N=C1N)C2C3C(C(O2)(CO3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N(C(C)C)C(C)C)OCCC#N
IUPAC Name: 3-[[(1R,3R,4R,7S)-3-(4-amino-5-methyl-2-oxopyrimidin-1-yl)-1-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-2,5-dioxabicyclo[2.2.1]heptan-7-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
InChI: InChI=1S/C41H50N5O8P/c1-27(2)46(28(3)4)55(52-23-11-22-42)54-36-35-38(45-24-29(5)37(43)44-39(45)47)53-40(36,25-50-35)26-51-41(30-12-9-8-10-13-30,31-14-18-33(48-6)19-15-31)32-16-20-34(49-7)21-17-32/h8-10,12-21,24,27-28,35-36,38H,11,23,25-26H2,1-7H3,(H2,43,44,47)/t35-,36+,38-,40-,55?/m1/s1
Synonyms: LNA-5-Me-C-CE Phosphoramidite; DMT-LNA-5mA phosphoramidite; 2(1H)-Pyrimidinone, 4-amino-1-[2,5-anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-α-L-lyxofuranosyl]-5-methyl-; 4-Amino-1-[2,5-anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-α-L-lyxofuranosyl]-5-methyl-2(1H)-pyrimidinone
DMT-LNA-G phosphoramidite
Description: DMT-LNA-G phosphoramidite is a modified phosphoramidite used in oligonucleotide synthesis, specifically for Locked Nucleic Acid (LNA) oligonucleotides. It contains a guanosine base modified with Locked Nucleic Acid (LNA) chemistry and a DMT (dimethoxytrityl) protecting group. This modification enhances the stability and binding affinity of the oligonucleotide to its complementary DNA or RNA strand. DMT-LNA-G phosphoramidite is commonly used in applications such as antisense therapy, PCR, and molecular diagnostics, where increased specificity and stability are required.
CAT: BRP-00812
CAS: 207131-17-7
Molecular Formula: C41H48N7O8P
Molecular Weight: 797.84
Purity: 98%
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Storage: Store at 2-8 °C, stored under nitrogen
InChIKey: FWLGFXLWSNDRLS-NVONNAQSSA-N
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C2C(OC1(CO2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)N6C=NC7=C6N=C(NC7=O)N
IUPAC Name: 3-[[(1R,3R,4R,7S)-3-(2-amino-6-oxo-1H-purin-9-yl)-1-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-2,5-dioxabicyclo[2.2.1]heptan-7-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
InChI: InChI=1S/C41H48N7O8P/c1-26(2)48(27(3)4)57(54-22-10-21-42)56-35-34-38(47-25-44-33-36(47)45-39(43)46-37(33)49)55-40(35,23-52-34)24-53-41(28-11-8-7-9-12-28,29-13-17-31(50-5)18-14-29)30-15-19-32(51-6)20-16-30/h7-9,11-20,25-27,34-35,38H,10,22-24H2,1-6H3,(H3,43,45,46,49)/t34-,35+,38-,40-,57?/m1/s1
Synonyms: Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O,4'-C-methylene-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; (1R,3R,4R,7S)-3-(2-Amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-1-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-2,5-dioxabicyclo[2.2.1]heptan-7-yl (2-cyanoethyl) diisopropylphosphoramidite
-amidite.gif)
LNA A(pac) amidite
Description: LNA A(pac) amidite is a modified phosphoramidite used in oligonucleotide synthesis, specifically for incorporating Locked Nucleic Acid (LNA) modifications into nucleic acid sequences. This modification involves attaching a phenoxyacetyl (pac) group to the adenine base of LNA. It is commonly used to enhance the binding affinity, stability, and specificity of oligonucleotides in various applications such as antisense therapy, PCR, and molecular diagnostics.
CAT: BRP-00813
Molecular Formula: C49H54N7O9P
Molecular Weight: 915.98
Purity: >98%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: RHUYJRYFCPQBIE-LXTWGDFWSA-N
Solubility: Soluble in Acetonitrile, DMF
IUPAC Name: (1R,3R,4R,7S)-1-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-(6-(2-phenoxyacetamido)-9H-purin-9-yl)-2,5-dioxabicyclo[2.2.1]heptan-7-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C49H54N7O9P/c1-33(2)56(34(3)4)66(63-27-13-26-50)65-44-43-47(55-32-53-42-45(51-31-52-46(42)55)54-41(57)28-60-40-16-11-8-12-17-40)64-48(44,29-61-43)30-62-49(35-14-9-7-10-15-35,36-18-22-38(58-5)23-19-36)37-20-24-39(59-6)25-21-37/h7-12,14-25,31-34,43-44,47H,13,27-30H2,1-6H3,(H,51,52,54,57)/t43-,44+,47-,48-,66?/m1/s1
Synonyms: LNA A(pac) CE-Phosphoramidite; DMTr-LNA-A(pac)-3-CED-phosphoramidite
2'-OTFM U amidite
Description: 2'-OTFM U amidite is a modified phosphoramidite used in oligonucleotide synthesis, particularly for introducing 2'-O-trifluoromethyl (OTFM) modifications into RNA sequences. This modification involves adding a trifluoromethyl group to the 2'-position of uridine. It is utilized to enhance the stability and specificity of RNA molecules in various applications such as RNA interference, antisense therapy, and RNA structural studies.
CAT: BRP-00814
CAS: 869734-94-1
Molecular Formula: C40H46F3N4O9P
Molecular Weight: 814.79
Purity: >95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: AIVSTWHGYKADBY-FNMBQTMFSA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OC(F)(F)F)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC
IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(2,4-dioxopyrimidin-1-yl)-4-(trifluoromethoxy)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
InChI: InChI=1S/C40H46F3N4O9P/c1-26(2)47(27(3)4)57(53-24-10-22-44)56-35-33(54-37(36(35)55-40(41,42)43)46-23-21-34(48)45-38(46)49)25-52-39(28-11-8-7-9-12-28,29-13-17-31(50-5)18-14-29)30-15-19-32(51-6)20-16-30/h7-9,11-21,23,26-27,33,35-37H,10,24-25H2,1-6H3,(H,45,48,49)/t33-,35-,36-,37-,57?/m1/s1
Synonyms: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(trifluoromethyl)-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-(trifluoromethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
-amidite.gif)
LNA G(iPr-pac) amidite
Description: LNA G(iPr-pac) amidite is a modified phosphoramidite used in oligonucleotide synthesis, specifically for incorporating Locked Nucleic Acid (LNA) modifications into nucleic acid sequences. This modification involves attaching an isopropylphenoxyacetyl (iPr-pac) group to the guanine base of LNA. It is commonly used to enhance the stability, specificity, and binding affinity of oligonucleotides in various applications such as antisense therapy, PCR, and molecular diagnostics.
CAT: BRP-00815
Molecular Formula: C52H60N7O10P
Molecular Weight: 974.06
Purity: >95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: FSLCFYFCVYNCAE-ZVOKJCSSSA-N
Solubility: Soluble in Acetonitrile, DMF
IUPAC Name: (1R,3R,4R,7S)-1-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-(2-(2-(4-isopropylphenoxy)acetamido)-6-oxo-1,6-dihydro-9H-purin-9-yl)-2,5-dioxabicyclo[2.2.1]heptan-7-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C52H60N7O10P/c1-33(2)36-15-21-42(22-16-36)64-29-43(60)55-50-56-47-44(48(61)57-50)54-32-58(47)49-45-46(69-70(67-28-12-27-53)59(34(3)4)35(5)6)51(68-49,30-65-45)31-66-52(37-13-10-9-11-14-37,38-17-23-40(62-7)24-18-38)39-19-25-41(63-8)26-20-39/h9-11,13-26,32-35,45-46,49H,12,28-31H2,1-8H3,(H2,55,56,57,60,61)/t45-,46+,49-,51-,70?/m1/s1
Synonyms: LNA G(iPr-pac) CE-Phosphoramidite; DMTr-LNA-G(iPr-pac)-3-CED-phosphoramidite
2'-OTFM C(Ac) amidite
Description: 2'-OTFM C(Ac) amidite is a modified phosphoramidite used in oligonucleotide synthesis to introduce 2'-O-trifluoromethyl (OTFM) modifications into RNA sequences, specifically targeting cytidine (C). This modification involves adding a trifluoromethyl group to the 2'-position of cytidine and acetylating the amino group of cytidine. It enhances the stability and specificity of RNA molecules and is commonly used in applications such as RNA interference, antisense therapy, and RNA structural studies.
CAT: BRP-00816
CAS: 869734-91-8
Molecular Formula: C42H49F3N5O9P
Molecular Weight: 855.85
Purity: >95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: VECFWZPFXRVLKY-HCIBFWJXSA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OC(F)(F)F)N2C=CC(=NC2=O)NC(=O)C)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC
IUPAC Name: N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-(trifluoromethoxy)oxolan-2-yl]-2-oxopyrimidin-4-yl]acetamide
InChI: InChI=1S/C42H49F3N5O9P/c1-27(2)50(28(3)4)60(56-25-11-23-46)59-37-35(57-39(38(37)58-42(43,44)45)49-24-22-36(47-29(5)51)48-40(49)52)26-55-41(30-12-9-8-10-13-30,31-14-18-33(53-6)19-15-31)32-16-20-34(54-7)21-17-32/h8-10,12-22,24,27-28,35,37-39H,11,25-26H2,1-7H3,(H,47,48,51,52)/t35-,37-,38-,39-,60?/m1/s1
Synonyms: Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(trifluoromethyl)-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; (2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(trifluoromethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; 2'-OTFM C(Ac) CE-Phosphoramidite
-amidite.gif)
2'-OTFM C(Bz) amidite
Description: 2'-OTFM C(Bz) amidite is a modified phosphoramidite used in oligonucleotide synthesis to introduce 2'-O-trifluoromethyl (OTFM) modifications into RNA sequences, specifically targeting cytidine (C). This modification involves adding a trifluoromethyl group to the 2'-position of cytidine and benzoylating the amino group of cytidine. It enhances the stability and specificity of RNA molecules and is commonly used in applications such as RNA interference, antisense therapy, and RNA structural studies.
CAT: BRP-00817
Molecular Formula: C47H51F3N5O9P
Molecular Weight: 917.92
Purity: >95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: APWVCZQYEKTHIH-WKNHZCODSA-N
Solubility: Soluble in Acetonitrile, DMF
IUPAC Name: (2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(trifluoromethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C47H51F3N5O9P/c1-31(2)55(32(3)4)65(61-29-13-27-51)64-41-39(62-44(42(41)63-47(48,49)50)54-28-26-40(53-45(54)57)52-43(56)33-14-9-7-10-15-33)30-60-46(34-16-11-8-12-17-34,35-18-22-37(58-5)23-19-35)36-20-24-38(59-6)25-21-36/h7-12,14-26,28,31-32,39,41-42,44H,13,29-30H2,1-6H3,(H,52,53,56,57)/t39-,41-,42-,44-,65?/m1/s1
Synonyms: 2'-OTFM C(Bz) CE-Phosphoramidite
-amidite.gif)
2'-OTFM G(iBu) amidite
Description: 2'-OTFM G(iBu) amidite is a modified phosphoramidite used in oligonucleotide synthesis to introduce 2'-O-trifluoromethyl (OTFM) modifications into RNA sequences, specifically targeting guanosine (G). This modification involves adding a trifluoromethyl group to the 2'-position of guanosine and attaching an isobutyl (iBu) group to the exocyclic amine of guanosine. It enhances the stability and specificity of RNA molecules and is commonly used in applications such as RNA interference, antisense therapy, and RNA structural studies.
CAT: BRP-00818
Molecular Formula: C45H53F3N7O9P
Molecular Weight: 923.93
Purity: >95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: YINYCQLAYPBOSI-SDLFASLNSA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N(C(C)C)C(C)C)OCCC#N)OC(F)(F)F
IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-(trifluoromethoxy)oxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide
InChI: InChI=1S/C45H53F3N7O9P/c1-27(2)40(56)52-43-51-39-36(41(57)53-43)50-26-54(39)42-38(63-45(46,47)48)37(64-65(61-24-12-23-49)55(28(3)4)29(5)6)35(62-42)25-60-44(30-13-10-9-11-14-30,31-15-19-33(58-7)20-16-31)32-17-21-34(59-8)22-18-32/h9-11,13-22,26-29,35,37-38,42H,12,24-25H2,1-8H3,(H2,51,52,53,56,57)/t35-,37-,38-,42-,65?/m1/s1
Synonyms: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(trifluoromethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; 2'-OTFM G(iBu) CE-Phosphoramidite
2'-OMe C(Ac) Me-amidite
Description: 2'-OMe C(Ac) Me-amidite is a modified phosphoramidite used in oligonucleotide synthesis, particularly for introducing 2'-O-methyl (2'-OMe) modifications into RNA sequences, specifically targeting cytidine (C). This modification involves adding a methyl group to the 2'-position of cytidine and acetylating the amino group of cytidine. It enhances the stability and specificity of RNA molecules and is commonly used in applications such as RNA interference, antisense therapy, and RNA structural studies.
CAT: BRP-00821
CAS: 205116-62-7
Molecular Formula: C40H51N4O8P
Molecular Weight: 746.84
Purity: >95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: QRMLMMQHOYHYLD-GFIGKZKCSA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: O=C1N=C(C=CN1C2OC(COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)C(OP(N(C(C)C)C(C)C)C)C2OC)NC(=O)C
IUPAC Name: N-(1-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((diisopropylamino)(methyl)phosphaneyl)oxy)-3-methoxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide
InChI: InChI=1S/C40H51N4O8P/c1-26(2)44(27(3)4)53(9)52-36-34(51-38(37(36)49-8)43-24-23-35(41-28(5)45)42-39(43)46)25-50-40(29-13-11-10-12-14-29,30-15-19-32(47-6)20-16-30)31-17-21-33(48-7)22-18-31/h10-24,26-27,34,36-38H,25H2,1-9H3,(H,41,42,45,46)/t34-,36-,37-,38-,53?/m1/s1
Synonyms: Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[P-methyl-N,N-bis(1-methylethyl)phosphonamidite]; 5'-O-DMTr-2'-OMe-C(Ac)-3'-O-[P-methyl-(N,N-diisopropyl)]-Phosphoramidite; N4-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-OMe-C-3'-O-[P-methyl-(N,N-diisopropyl)]-Phosphoramidite; 2'-O-Methyl Cytidine (n-acetyl) p-methyl phosphonamidite; 5'-O-DMTr-2'-OMe-C(Ac) methyl phosphonamidite
2'-OMe A(Bz) Me-amidite
Description: 2'-OMe A(Bz) Me-amidite is a modified phosphoramidite used in oligonucleotide synthesis to introduce 2'-O-methyl (2'-OMe) modifications into RNA sequences, specifically targeting adenosine (A). This modification involves adding a methyl group to the 2'-position of adenosine and benzoylating the amino group of adenosine. It enhances the stability and specificity of RNA molecules and is commonly used in applications such as RNA interference, antisense therapy, and RNA structural studies.
CAT: BRP-00822
CAS: 158691-23-7
Molecular Formula: C46H53N6O7P
Molecular Weight: 832.94
Purity: >95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: GICXOURJNDWAPG-NSWJMSGMSA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: O=C(NC1=NC=NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP(N(C(C)C)C(C)C)C)C3OC)C=7C=CC=CC7
IUPAC Name: N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((diisopropylamino)(methyl)phosphaneyl)oxy)-3-methoxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide
InChI: InChI=1S/C46H53N6O7P/c1-30(2)52(31(3)4)60(8)59-40-38(58-45(41(40)56-7)51-29-49-39-42(47-28-48-43(39)51)50-44(53)32-15-11-9-12-16-32)27-57-46(33-17-13-10-14-18-33,34-19-23-36(54-5)24-20-34)35-21-25-37(55-6)26-22-35/h9-26,28-31,38,40-41,45H,27H2,1-8H3,(H,47,48,50,53)/t38-,40-,41-,45-,60?/m1/s1
Synonyms: Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[P-methyl-N,N-bis(1-methylethyl)phosphonamidite]; 5'-O-DMTr-2'-OMe-A(Bz)-3'-O-[P-methyl-(N,N-diisopropyl)]-Phosphoramidite; N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-OMe-adenosine-3'-O-[P-methyl-(N,N-diisopropyl)]-Phosphoramidite; 2'-O-Methyl Adenosine (n-bz) p-methyl phosphonamidite; 5'-O-DMTr-2'-OMe-A(Bz) methyl phosphonamidite
2'-OMe G(iBu) Me-amidite
Description: 2'-OMe G(iBu) Me-amidite is a modified phosphoramidite used in oligonucleotide synthesis to introduce 2'-O-methyl (2'-OMe) modifications into RNA sequences, specifically targeting guanosine (G). This modification involves adding a methyl group to the 2'-position of guanosine and attaching an isobutyl (iBu) group to the exocyclic amine of guanosine. It enhances the stability and specificity of RNA molecules and is commonly used in applications such as RNA interference, antisense therapy, and RNA structural studies.
CAT: BRP-00823
CAS: 191786-63-7
Molecular Formula: C43H55N6O8P
Molecular Weight: 814.92
Purity: >95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: JAVHPGCWDJVLLN-BSQJSOGMSA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: O=C1N=C(NC(=O)C(C)C)NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP(N(C(C)C)C(C)C)C)C3OC
IUPAC Name: N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((diisopropylamino)(methyl)phosphaneyl)oxy)-3-methoxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide
InChI: InChI=1S/C43H55N6O8P/c1-26(2)39(50)46-42-45-38-35(40(51)47-42)44-25-48(38)41-37(54-9)36(57-58(10)49(27(3)4)28(5)6)34(56-41)24-55-43(29-14-12-11-13-15-29,30-16-20-32(52-7)21-17-30)31-18-22-33(53-8)23-19-31/h11-23,25-28,34,36-37,41H,24H2,1-10H3,(H2,45,46,47,50,51)/t34-,36-,37-,41-,58?/m1/s1
Synonyms: Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-N-(2-methyl-1-oxopropyl)-, 3'-[P-methyl-N,N-bis(1-methylethyl)phosphonamidite]; 5'-O-DMTr-2'-OMe-G(iBu)-3'-O-[P-methyl-(N,N-diisopropyl)]-Phosphoramidite; N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-OMe-G-3'-O-[P-methyl-(N,N-diisopropyl)]-Phosphoramidite; 2'-O-Methyl Guanosine (n-ibu) p-methyl phosphonamidite; 5'-O-DMTr-2'-OMe-G(iBu) methyl phosphonamidite
MMTr C7 amine amidite
Description: MMTr C7 amine amidite is a linker phosphoramidite used in oligonucleotide synthesis. This compound serves as a linker during solid-phase oligonucleotide synthesis, allowing for the attachment of nucleotide building blocks to a growing oligonucleotide chain. MMTr C7 amine amidite plays a crucial role in the efficient and controlled synthesis of modified oligonucleotides for various applications in molecular biology and biotechnology.
CAT: BRP-00824
Molecular Formula: C36H50N3O3P
Molecular Weight: 603.79
Purity: >95%
Appearance: Light-yellow oily matter
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Storage: Store at -20 °C
InChIKey: SESSADZGYXHMSJ-UHFFFAOYSA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: CC(C)N(C(C)C)P(OCCCCCCCNC(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=C(C=C3)OC)OCCC#N
IUPAC Name: 3-[[di(propan-2-yl)amino]-[7-[[(4-methoxyphenyl)-diphenylmethyl]amino]heptoxy]phosphanyl]oxypropanenitrile
InChI: InChI=1S/C36H50N3O3P/c1-30(2)39(31(3)4)43(42-29-17-26-37)41-28-16-8-6-7-15-27-38-36(32-18-11-9-12-19-32,33-20-13-10-14-21-33)34-22-24-35(40-5)25-23-34/h9-14,18-25,30-31,38H,6-8,15-17,27-29H2,1-5H3
Synonyms: 2-cyanoethyl (7-(((4-methoxyphenyl)diphenylmethyl)amino)heptyl) diisopropylphosphoramidite; NHMMTr-C7 Phosphoramidite; Monomethoxytrityl-heptylamine-linker Phosphoramidite
MMTr C5 amine amidite
Description: MMTr C5 amine amidite is a linker phosphoramidite used in oligonucleotide synthesis. This compound serves as a linker during solid-phase oligonucleotide synthesis, allowing the attachment of nucleotide building blocks to a growing oligonucleotide chain. MMTr C5 amine amidite plays a crucial role in the efficient and controlled synthesis of modified oligonucleotides for various applications in molecular biology and biotechnology.
CAT: BRP-00825
CAS: 178811-39-7
Molecular Formula: C34H46N3O3P
Molecular Weight: 575.73
Purity: >95%
Appearance: Light-yellow oily matter
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Storage: Store at -20 °C
InChIKey: QKLNHYFSRTYCRA-UHFFFAOYSA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OCCCCCNC(C1=CC=C(OC)C=C1)(C2=CC=CC=C2)C3=CC=CC=C3
IUPAC Name: 2-cyanoethyl (5-(((4-methoxyphenyl)diphenylmethyl)amino)pentyl) diisopropylphosphoramidite
InChI: InChI=1S/C34H46N3O3P/c1-28(2)37(29(3)4)41(40-27-15-24-35)39-26-14-8-13-25-36-34(30-16-9-6-10-17-30,31-18-11-7-12-19-31)32-20-22-33(38-5)23-21-32/h6-7,9-12,16-23,28-29,36H,8,13-15,25-27H2,1-5H3
Synonyms: NHMMTr-C5 Phosphoramidite; Monomethoxytrityl-pentylamine-linker Phosphoramidite
MMTr C4 amine amidite
Description: MMTr C4 amine amidite is a linker phosphoramidite used in oligonucleotide synthesis. This compound serves as a linker during solid-phase oligonucleotide synthesis, facilitating the attachment of nucleotide building blocks to a growing oligonucleotide chain. MMTr C4 amine amidite is essential for the controlled synthesis of modified oligonucleotides for various applications in molecular biology and biotechnology.
CAT: BRP-00826
CAS: 178811-38-6
Molecular Formula: C33H44N3O3P
Molecular Weight: 561.71
Purity: >95%
Appearance: Light-yellow oily matter
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Storage: Store at -20 °C
InChIKey: LVYNYJLDPZLYCP-UHFFFAOYSA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OCCCCNC(C1=CC=C(OC)C=C1)(C2=CC=CC=C2)C3=CC=CC=C3
IUPAC Name: 2-cyanoethyl (4-(((4-methoxyphenyl)diphenylmethyl)amino)butyl) diisopropylphosphoramidite
InChI: InChI=1S/C33H44N3O3P/c1-27(2)36(28(3)4)40(39-26-14-23-34)38-25-13-12-24-35-33(29-15-8-6-9-16-29,30-17-10-7-11-18-30)31-19-21-32(37-5)22-20-31/h6-11,15-22,27-28,35H,12-14,24-26H2,1-5H3
Synonyms: NHMMTr-C4 Phosphoramidite; Monomethoxytrityl-butylamine-linker Phosphoramidite
MMTr C2 amine amidite
Description: MMTr C2 amine amidite is a linker phosphoramidite used in oligonucleotide synthesis. This compound serves as a linker during solid-phase oligonucleotide synthesis, enabling the attachment of nucleotide building blocks to a growing oligonucleotide chain. MMTr C2 amine amidite is crucial for the controlled synthesis of modified oligonucleotides for various applications in molecular biology and biotechnology.
CAT: BRP-00827
Molecular Formula: C31H40N3O3P
Molecular Weight: 533.65
Purity: >95%
Appearance: Light-yellow oily matter
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Storage: Store at -20 °C
InChIKey: TVYYYWLTEUUCSU-UHFFFAOYSA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OCCNC(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=C(C=C3)OC
IUPAC Name: 3-[[di(propan-2-yl)amino]-[2-[[(4-methoxyphenyl)-diphenylmethyl]amino]ethoxy]phosphanyl]oxypropanenitrile
InChI: InChI=1S/C31H40N3O3P/c1-25(2)34(26(3)4)38(36-23-12-21-32)37-24-22-33-31(27-13-8-6-9-14-27,28-15-10-7-11-16-28)29-17-19-30(35-5)20-18-29/h6-11,13-20,25-26,33H,12,22-24H2,1-5H3
Synonyms: 2-cyanoethyl (2-(((4-methoxyphenyl)diphenylmethyl)amino)ethyl) diisopropylphosphoramidite; MMTr C2 linker Phosphoramidite; MMT-ethylamine-linker Phosphoramidite; NHMMTr-C2 Phosphoramidite
