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2'-Modified Phosphoramidites
(466/466) 2'-Phosphoramidites
(21/21) 3'-Modified Phosphoramidites
(186/186) 5'-Modified Phosphoramidites
(21/21) Arabino Phosphoramidites
(19/19) Base Protected Phosphoramidites (365/365) Dye Phosphoramidites
(53/53) Label Phosphoramidites
(82/82) Linker Phosphoramidites
(72/72) Other Phosphoramidites
(92/92) PMO Phosphoramidates and Derivatives (33/33) PseudoUridine Phosphoramidite
(12/12) Reverse Phosphoramidites
(15/15) Spacer Phosphoramidites
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(466/466) 2'-Phosphoramidites
(21/21) 3'-Modified Phosphoramidites
(186/186) 5'-Modified Phosphoramidites
(21/21) Arabino Phosphoramidites
(19/19) Base Protected Phosphoramidites (365/365) Dye Phosphoramidites
(53/53) Label Phosphoramidites
(82/82) Linker Phosphoramidites
(72/72) Other Phosphoramidites
(92/92) PMO Phosphoramidates and Derivatives (33/33) PseudoUridine Phosphoramidite
(12/12) Reverse Phosphoramidites
(15/15) Spacer Phosphoramidites
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-amidite.gif)
ENA A(dmf) amidite
Description: ENA A(dmf) amidite is a modified phosphoramidite used in oligonucleotide synthesis. This compound is essential for synthesizing oligonucleotides with ENA backbone modifications, which can impart enhanced stability and other desirable properties for applications such as antisense technology, RNA research, and diagnostics.
CAT: BRP-00913
MF: C45H55N8O7P
MF: 850.96
Purity: >95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: AQCTXDYCTBALJS-XCDQGDGNSA-N
Solubility: Soluble in Acetonitrile, DMF
IUPAC Name: (1R,5R,7R,8S)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-7-(6-(((dimethylamino)methylene)amino)-9H-purin-9-yl)-2,6-dioxabicyclo[3.2.1]octan-8-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C45H55N8O7P/c1-31(2)53(32(3)4)61(58-25-12-24-46)60-40-39-43(52-30-49-38-41(50-29-51(5)6)47-28-48-42(38)52)59-44(40,23-26-56-39)27-57-45(33-13-10-9-11-14-33,34-15-19-36(54-7)20-16-34)35-17-21-37(55-8)22-18-35/h9-11,13-22,28-32,39-40,43H,12,23,25-27H2,1-8H3/t39-,40+,43-,44-,61?/m1/s1
Synonyms: ENA A(dmf) Phosphoramidite
-amidite.gif)
FNA A(Bz) amidite
Description: FNA A(Bz) amidite is a phosphoramidite reagent used in solid-phase oligonucleotide synthesis, specifically for the incorporation of FNA monomers into oligonucleotide sequences. FNA A(Bz) amidite contains a benzoyl (Bz) protecting group on the adenine base. It is utilized for the synthesis of modified oligonucleotides containing FNA nucleotide analogs, which confer enhanced nuclease resistance and stability to the oligonucleotide duplexes. It finds applications in antisense technology, RNA interference (RNAi), and other nucleic acid-based research fields.
CAT: BRP-00914
MF: C46H52N7O7P
MF: 845.94
Purity: >98%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: JDILKNZRQTXVQP-DFVFTTOBSA-N
Solubility: Soluble in Acetonitrile, DMF
IUPAC Name: (R)-2-((6-benzamido-9H-purin-9-yl)methoxy)-3-(bis(4-methoxyphenyl)(phenyl)methoxy)propyl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C46H52N7O7P/c1-33(2)53(34(3)4)61(59-27-13-26-47)60-29-41(57-32-52-31-50-42-43(48-30-49-44(42)52)51-45(54)35-14-9-7-10-15-35)28-58-46(36-16-11-8-12-17-36,37-18-22-39(55-5)23-19-37)38-20-24-40(56-6)25-21-38/h7-12,14-25,30-31,33-34,41H,13,27-29,32H2,1-6H3,(H,48,49,51,54)/t41-,61?/m1/s1
Synonyms: DMTr-FNA-A(Bz)phosphoramidite
FNA G(Ac) amidite
Description: FNA G(Ac) amidite is a phosphoramidite reagent used in solid-phase oligonucleotide synthesis, specifically for the incorporation of FNA monomers into oligonucleotide sequences. FNA G(Ac) amidite contains an acetyl (Ac) protecting group on the guanine base. It is utilized for the synthesis of modified oligonucleotides containing FNA nucleotide analogs, which confer enhanced nuclease resistance and stability to the oligonucleotide duplexes. It finds applications in antisense technology, RNA interference (RNAi), and other nucleic acid-based research fields.
CAT: BRP-00915
CAS: 208758-63-8
MF: C41H50N7O8P
MF: 799.87
Purity: >98%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: WYKRXWSAMISEIB-COURYUFRSA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: N#CCCOP(OCC(OCN1C=NC=2NC(=NC(=O)C21)NC(=O)C)COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)N(C(C)C)C(C)C
IUPAC Name: (R)-2-((2-acetamido-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy)-3-(bis(4-methoxyphenyl)(phenyl)methoxy)propyl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C41H50N7O8P/c1-28(2)48(29(3)4)57(55-23-11-22-42)56-25-36(53-27-47-26-43-38-37(47)39(50)46-40(45-38)44-30(5)49)24-54-41(31-12-9-8-10-13-31,32-14-18-34(51-6)19-15-32)33-16-20-35(52-7)21-17-33/h8-10,12-21,26,28-29,36H,11,23-25,27H2,1-7H3,(H2,44,45,46,49,50)/t36-,57?/m1/s1
Synonyms: Phosphoramidous acid, bis(1-methylethyl)-, (2R)-2-[[2-(acetylamino)-1,6-dihydro-6-oxo-7H-purin-7-yl]methoxy]-3-[bis(4-methoxyphenyl)phenylmethoxy]propyl 2-cyanoethyl ester; DMTr-FNA-G(Ac)phosphoramidite
2'-OTBS O6-NPE-G(Me) amidite
Description: 2'-OTBS O6-NPE-G(Me) amidite is a modified phosphoramidite used in oligonucleotide synthesis. It features a guanosine nucleotide modified at the 2' position with a tert-butyldimethylsilyl (OTBS) protecting group and at the O6 position with a nitrophenylethyl (NPE) group, along with a methyl group modification. This compound is utilized in solid-phase oligonucleotide synthesis to incorporate specifically modified nucleosides into oligonucleotide sequences. Such modifications are important for studies in molecular biology, diagnostics, and therapeutic applications, providing enhanced stability and specific properties to the synthesized oligonucleotides.
CAT: BRP-00916
CAS: 219648-40-5
MF: C55H71N8O10PSi
MF: 1063.28
Purity: >95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: DFBXNVVGLXNLNJ-UVQCDVNLSA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=NC3=C2N=C(N=C3OCCC4=CC=C(C=C4)[N+](=O)[O-])NC)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC
IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-5-[2-(methylamino)-6-[2-(4-nitrophenyl)ethoxy]purin-9-yl]oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
InChI: InChI=1S/C55H71N8O10PSi/c1-37(2)62(38(3)4)74(70-33-16-32-56)72-48-46(35-69-55(40-17-14-13-15-18-40,41-21-27-44(66-9)28-22-41)42-23-29-45(67-10)30-24-42)71-52(49(48)73-75(11,12)54(5,6)7)61-36-58-47-50(61)59-53(57-8)60-51(47)68-34-31-39-19-25-43(26-20-39)63(64)65/h13-15,17-30,36-38,46,48-49,52H,16,31,33-35H2,1-12H3,(H,57,59,60)/t46-,48-,49-,52-,74?/m1/s1
Synonyms: Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-N-methyl-6-O-[2-(4-nitrophenyl)ethyl]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2-(methylamino)-6-(4-nitrophenethoxy)-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
2'-OTBS O6-NPE-G(di-Me) amidite
Description: 2'-OTBS O6-NPE-G(di-Me) amidite is a modified phosphoramidite used in oligonucleotide synthesis. It features a guanosine nucleotide modified at the 2' position with a tert-butyldimethylsilyl (OTBS) protecting group and at the O6 position with a nitrophenylethyl (NPE) group, along with two methyl (di-Me) group modifications. This compound is utilized in solid-phase oligonucleotide synthesis to incorporate specifically modified nucleosides into oligonucleotide sequences. Such modifications are important for studies in molecular biology, diagnostics, and therapeutic applications, providing enhanced stability and specific properties to the synthesized oligonucleotides.
CAT: BRP-00917
CAS: 2104647-87-0
MF: C56H73N8O10PSi
MF: 1077.31
Purity: >98%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: ZEHMGNXQYCLVHJ-UTZPLLLRSA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C(=NC(=NC32)N(C)C)OCCC4=CC=C(C=C4)N(=O)=O)C1O[Si](C)(C)C(C)(C)C)COC(C=5C=CC=CC5)(C6=CC=C(OC)C=C6)C7=CC=C(OC)C=C7)N(C(C)C)C(C)C
IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2-(dimethylamino)-6-(4-nitrophenethoxy)-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C56H73N8O10PSi/c1-38(2)63(39(3)4)75(71-34-17-33-57)73-49-47(36-70-56(41-18-15-14-16-19-41,42-22-28-45(67-10)29-23-42)43-24-30-46(68-11)31-25-43)72-53(50(49)74-76(12,13)55(5,6)7)62-37-58-48-51(62)59-54(61(8)9)60-52(48)69-35-32-40-20-26-44(27-21-40)64(65)66/h14-16,18-31,37-39,47,49-50,53H,17,32,34-36H2,1-13H3/t47-,49-,50-,53-,75?/m1/s1
Synonyms: Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-N,N-dimethyl-6-O-[2-(4-nitrophenyl)ethyl]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]
2'-OTBS N1-Me-I amidite
Description: 2'-OTBS N1-Me-I amidite is a modified phosphoramidite used in oligonucleotide synthesis. It features a nucleoside with a tert-butyldimethylsilyl (OTBS) protecting group at the 2' position and a methyl group at the N1 position of the base. This specific modification involves inosine (I), a purine nucleoside. This compound is employed in solid-phase oligonucleotide synthesis to incorporate modified nucleosides into oligonucleotide sequences, providing enhanced stability and specific properties. These modifications are valuable for applications in molecular biology, diagnostics, and therapeutic development.
CAT: BRP-00918
CAS: 236752-21-9
MF: C47H63N6O8PSi
MF: 899.11
Purity: >95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: USHFHCSKQCIRHW-UTZPQXNGSA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C(=O)N(C=NC32)C)C1O[Si](C)(C)C(C)(C)C)COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C
IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(1-methyl-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C47H63N6O8PSi/c1-32(2)53(33(3)4)62(58-28-16-27-48)60-41-39(59-45(42(41)61-63(11,12)46(5,6)7)52-31-49-40-43(52)50-30-51(8)44(40)54)29-57-47(34-17-14-13-15-18-34,35-19-23-37(55-9)24-20-35)36-21-25-38(56-10)26-22-36/h13-15,17-26,30-33,39,41-42,45H,16,28-29H2,1-12H3/t39-,41-,42-,45-,62?/m1/s1
Synonyms: Inosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-1-methyl-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]
isoGNA A(Bz) amidite
Description: isoGNA A(Bz) amidite is a modified phosphoramidite used in oligonucleotide synthesis. It features an adenine (A) base protected with a benzoyl (Bz) group, incorporated into an isoglycerol nucleic acid (isoGNA) backbone. This compound is utilized in solid-phase oligonucleotide synthesis to incorporate modified nucleosides with isoGNA backbones into oligonucleotide sequences. Such modifications are important for enhancing the stability, binding affinity, and specificity of synthetic oligonucleotides, making them useful for applications in molecular biology, diagnostics, and therapeutic research.
CAT: BRP-00919
CAS: 1443744-41-9
MF: C45H50N7O6P
MF: 815.91
Purity: >95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: JAPSRHIYKAJUIR-UOJNEOKMSA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: N#CCCOP(OCC(N1C=NC=2C(=NC=NC21)NC(=O)C=3C=CC=CC3)COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C
IUPAC Name: (S)-2-(6-benzamido-9H-purin-9-yl)-3-(bis(4-methoxyphenyl)(phenyl)methoxy)propyl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C45H50N7O6P/c1-32(2)52(33(3)4)59(57-27-13-26-46)58-29-38(51-31-49-41-42(47-30-48-43(41)51)50-44(53)34-14-9-7-10-15-34)28-56-45(35-16-11-8-12-17-35,36-18-22-39(54-5)23-19-36)37-20-24-40(55-6)25-21-37/h7-12,14-25,30-33,38H,13,27-29H2,1-6H3,(H,47,48,50,53)/t38-,59?/m0/s1
Synonyms: Phosphoramidous acid, N,N-bis(1-methylethyl)-, (2S)-2-[6-(benzoylamino)-9H-purin-9-yl]-3-[bis(4-methoxyphenyl)phenylmethoxy]propyl 2-cyanoethyl ester; (2S)-2-[6-(Benzoylamino)-9H-purin-9-yl]-3-[bis(4-methoxyphenyl)phenylmethoxy]propyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite
isoGNA C(iBu) amidite
Description: isoGNA C(iBu) amidite is a modified phosphoramidite used in oligonucleotide synthesis. It features a cytosine (C) base protected with an isobutyryl (iBu) group, integrated into an isoglycerol nucleic acid (isoGNA) backbone. This compound is employed in solid-phase oligonucleotide synthesis to incorporate modified nucleosides with isoGNA backbones into oligonucleotide sequences. These modifications enhance the stability, binding affinity, and specificity of synthetic oligonucleotides, making them valuable for various applications in molecular biology, diagnostics, and therapeutic development.
CAT: BRP-00920
CAS: 1443744-42-0
MF: C41H52N5O7P
MF: 757.87
Purity: >95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: XGLKXRATAYJCHB-XYMJDGAWSA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: N#CCCOP(OCC(N1C=CC(=NC1=O)NC(=O)C(C)C)COC(C=2C=CC=CC2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)N(C(C)C)C(C)C
IUPAC Name: (S)-3-(bis(4-methoxyphenyl)(phenyl)methoxy)-2-(4-isobutyramido-2-oxopyrimidin-1(2H)-yl)propyl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C41H52N5O7P/c1-29(2)39(47)43-38-23-25-45(40(48)44-38)35(28-53-54(52-26-12-24-42)46(30(3)4)31(5)6)27-51-41(32-13-10-9-11-14-32,33-15-19-36(49-7)20-16-33)34-17-21-37(50-8)22-18-34/h9-11,13-23,25,29-31,35H,12,26-28H2,1-8H3,(H,43,44,47,48)/t35-,54?/m0/s1
Synonyms: Phosphoramidous acid, N,N-bis(1-methylethyl)-, (2S)-3-[bis(4-methoxyphenyl)phenylmethoxy]-2-[4-[(2-methyl-1-oxopropyl)amino]-2-oxo-1(2H)-pyrimidinyl]propyl 2-cyanoethyl ester; (2S)-3-[Bis(4-methoxyphenyl)phenylmethoxy]-2-[4-[(2-methyl-1-oxopropyl)amino]-2-oxo-1(2H)-pyrimidinyl]propyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite
isoGNA O6-DPC-G(iBu) amidite
Description: isoGNA O6-DPC-G(iBu) amidite is a modified phosphoramidite used in oligonucleotide synthesis. It features a guanine (G) base with an O6-DPC (diphenylcarbamoyl) modification and an isobutyryl (iBu) protecting group, integrated into an isoglycerol nucleic acid (isoGNA) backbone. This compound is utilized in solid-phase oligonucleotide synthesis to incorporate specifically modified nucleosides with isoGNA backbones into oligonucleotide sequences. These modifications are important for enhancing the stability, binding affinity, and specificity of synthetic oligonucleotides, making them valuable for applications in molecular biology, diagnostics, and therapeutic research.
CAT: BRP-00921
CAS: 1638739-09-9
MF: C55H61N8O8P
MF: 993.12
Purity: >98%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: CNQFTLNOLDNADK-IKGLYBOLSA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: N#CCCOP(OCC(N1C=NC=2C(=NC(=NC21)NC(=O)C(C)C)OC(=O)N(C=3C=CC=CC3)C=4C=CC=CC4)COC(C=5C=CC=CC5)(C6=CC=C(OC)C=C6)C7=CC=C(OC)C=C7)N(C(C)C)C(C)C
IUPAC Name: 9-((2S)-1-(bis(4-methoxyphenyl)(phenyl)methoxy)-3-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)propan-2-yl)-2-isobutyramido-9H-purin-6-yl diphenylcarbamate
InChI: InChI=1S/C55H61N8O8P/c1-38(2)51(64)59-53-58-50-49(52(60-53)71-54(65)62(44-21-14-10-15-22-44)45-23-16-11-17-24-45)57-37-61(50)46(36-70-72(69-34-18-33-56)63(39(3)4)40(5)6)35-68-55(41-19-12-9-13-20-41,42-25-29-47(66-7)30-26-42)43-27-31-48(67-8)32-28-43/h9-17,19-32,37-40,46H,18,34-36H2,1-8H3,(H,58,59,60,64)/t46-,72?/m0/s1
Synonyms: Carbamic acid, N,N-diphenyl-, 9-[(1S)-2-[bis(4-methoxyphenyl)phenylmethoxy]-1-[[[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]oxy]methyl]ethyl]-2-[(2-methyl-1-oxopropyl)amino]-9H-purin-6-yl ester; 9-[(1S)-2-[Bis(4-methoxyphenyl)phenylmethoxy]-1-[[[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]oxy]methyl]ethyl]-2-[(2-methyl-1-oxopropyl)amino]-9H-purin-6-yl N,N-diphenylcarbamate
2'-MOE A(Bz) MOP-amidite
Description: 2'-MOE A(Bz) MOP-amidite is a modified phosphoramidite used in oligonucleotide synthesis. It features an adenine (A) base protected with a benzoyl (Bz) group and a 2'-O-methoxyethyl (2'-MOE) modification. This compound is employed in solid-phase oligonucleotide synthesis to incorporate nucleosides with 2'-MOE modifications into oligonucleotide sequences. These modifications enhance the stability, binding affinity, and nuclease resistance of synthetic oligonucleotides, making them valuable for various applications in molecular biology, diagnostics, and therapeutic development.
CAT: BRP-00922
CAS: 1821310-27-3
MF: C51H63N6O9P
MF: 935.07
Purity: >95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: BZDIHPNWZGXHOG-LTMMGAFGSA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: O=C(NC1=NC=NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP(N(C(C)C)C(C)C)CCCOC)C3OCCOC)C=7C=CC=CC7
IUPAC Name: N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((diisopropylamino)(3-methoxypropyl)phosphaneyl)oxy)-3-(2-methoxyethoxy)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide
InChI: InChI=1S/C51H63N6O9P/c1-35(2)57(36(3)4)67(31-15-28-59-5)66-45-43(32-64-51(38-18-13-10-14-19-38,39-20-24-41(61-7)25-21-39)40-22-26-42(62-8)27-23-40)65-50(46(45)63-30-29-60-6)56-34-54-44-47(52-33-53-48(44)56)55-49(58)37-16-11-9-12-17-37/h9-14,16-27,33-36,43,45-46,50H,15,28-32H2,1-8H3,(H,52,53,55,58)/t43-,45-,46-,50-,67?/m1/s1
Synonyms: Adenosine, N-benzoyl-5'-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-, 3'-[P-(3-methoxypropyl)-N,N-bis(1-methylethyl)phosphonamidite]
2'-MOE G(iBu) MOP-amidite
Description: 2'-MOE G(iBu) MOP-amidite is a modified phosphoramidite used in oligonucleotide synthesis. It features a guanine (G) base protected with an isobutyryl (iBu) group and a 2'-O-methoxyethyl (2'-MOE) modification. This compound is utilized in solid-phase oligonucleotide synthesis to incorporate nucleosides with 2'-MOE modifications into oligonucleotide sequences. These modifications enhance the stability, binding affinity, and nuclease resistance of synthetic oligonucleotides, making them valuable for various applications in molecular biology, diagnostics, and therapeutic development.
CAT: BRP-00923
CAS: 1821310-28-4
MF: C48H65N6O10P
MF: 917.05
Purity: >95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: XUVMXOOSPSMHGP-VKFKYRIUSA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: O=C1N=C(NC(=O)C(C)C)NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP(N(C(C)C)C(C)C)CCCOC)C3OCCOC
IUPAC Name: N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((diisopropylamino)(3-methoxypropyl)phosphaneyl)oxy)-3-(2-methoxyethoxy)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide
InChI: InChI=1S/C48H65N6O10P/c1-31(2)44(55)51-47-50-43-40(45(56)52-47)49-30-53(43)46-42(61-27-26-58-8)41(64-65(28-14-25-57-7)54(32(3)4)33(5)6)39(63-46)29-62-48(34-15-12-11-13-16-34,35-17-21-37(59-9)22-18-35)36-19-23-38(60-10)24-20-36/h11-13,15-24,30-33,39,41-42,46H,14,25-29H2,1-10H3,(H2,50,51,52,55,56)/t39-,41-,42-,46-,65?/m1/s1
Synonyms: Guanosine, 5'-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-N-(2-methyl-1-oxopropyl)-, 3'-[P-(3-methoxypropyl)-N,N-bis(1-methylethyl)phosphonamidite]
2'-OMe G(iBu) OBn-amidite
Description: 2'-OMe G(iBu) OBn-amidite is a modified phosphoramidite used in oligonucleotide synthesis. It contains a guanosine nucleoside modified with a 2'-O-methyl (2'-OMe) group and an isobutyl (iBu) protecting group. Additionally, the benzyl (Bn) group is attached to the phosphoramidite moiety. This compound is employed in solid-phase oligonucleotide synthesis to incorporate specifically modified guanosine nucleosides into oligonucleotide sequences. The 2'-O-methyl modification enhances stability, while the isobutyl and benzyl protecting groups provide selective protection during synthesis, allowing precise control over nucleotide incorporation.
CAT: BRP-00930
CAS: 2068810-62-6
MF: C49H59N6O9P
MF: 907.02
Purity: >95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: DOXQHYSXYPLQNS-KLJQIIHSSA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: O=C1N=C(NC(=O)C(C)C)NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP(OCC=7C=CC=CC7)N(C(C)C)C(C)C)C3OC
IUPAC Name: benzyl ((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl) diisopropylphosphoramidite
InChI: InChI=1S/C49H59N6O9P/c1-31(2)45(56)52-48-51-44-41(46(57)53-48)50-30-54(44)47-43(60-9)42(64-65(55(32(3)4)33(5)6)62-28-34-16-12-10-13-17-34)40(63-47)29-61-49(35-18-14-11-15-19-35,36-20-24-38(58-7)25-21-36)37-22-26-39(59-8)27-23-37/h10-27,30-33,40,42-43,47H,28-29H2,1-9H3,(H2,51,52,53,56,57)/t40-,42-,43-,47-,65?/m1/s1
Synonyms: N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methylguanosine-3'-benzyloxy-phosphoramidite; 5'-O-DMTr-2'-OMe-G(iBu)-3'-benzyloxy-phosphoramidite; N2-iBu 2'-OMe G OBn-amidite; 2'-OMe Guanosine (n-ibu) benzyloxy phosphoramidite
2'-OTIPS 5-propynyl-U Obutyn-amidite
Description: 2'-OTIPS 5-propynyl-U Obutyn-amidite is a modified phosphoramidite used in oligonucleotide synthesis. It contains a uridine nucleoside modified with a 2'-O-triisopropylsilyl (2'-OTIPS) group and a 3-butynyl (Obutyn) group attached to the phosphoramidite moiety. This compound is employed in solid-phase oligonucleotide synthesis to incorporate specifically modified uridine nucleosides into oligonucleotide sequences. The 2'-O-triisopropylsilyl group protects the 2' hydroxyl group, while the 3-butynyl group provides a functional handle for further modification. It allows precise control over nucleotide incorporation and subsequent conjugation or labeling reactions.
CAT: BRP-00931
MF: C52H70N3O9PSi
MF: 940.20
Purity: >95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: SCESTXDXTKPIHA-WTWWAFAISA-N
Solubility: Soluble in Acetonitrile, DMF
IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-5-(prop-1-yn-1-yl)-3,4-dihydropyrimidin-1(2H)-yl)-4-((triisopropylsilyl)oxy)tetrahydrofuran-3-yl but-3-yn-1-yl diisopropylphosphoramidite
InChI: InChI=1S/C52H70N3O9PSi/c1-15-17-32-61-65(55(35(3)4)36(5)6)63-47-46(62-50(54-33-40(21-16-2)49(56)53-51(54)57)48(47)64-66(37(7)8,38(9)10)39(11)12)34-60-52(41-22-19-18-20-23-41,42-24-28-44(58-13)29-25-42)43-26-30-45(59-14)31-27-43/h1,18-20,22-31,33,35-39,46-48,50H,17,32,34H2,2-14H3,(H,53,56,57)/t46-,47-,48-,50-,65?/m1/s1
2'-OMe U Obutyn-amidite
Description: 2'-OMe U Obutyn-amidite is a modified phosphoramidite used in oligonucleotide synthesis. It contains a uridine nucleoside modified with a 2'-O-methyl (2'-OMe) group. This compound is employed in solid-phase oligonucleotide synthesis to incorporate specifically modified uridine nucleosides into oligonucleotide sequences. The 2'-O-methyl group enhances stability. It allows precise control over nucleotide incorporation and subsequent conjugation or labeling reactions.
CAT: BRP-00932
MF: C41H50N3O9P
MF: 759.84
Purity: >95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: DDNPMEIKNDZJFN-KCTKLGORSA-N
Solubility: Soluble in Acetonitrile, DMF
IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl but-3-yn-1-yl diisopropylphosphoramidite
InChI: InChI=1S/C41H50N3O9P/c1-9-10-26-51-54(44(28(2)3)29(4)5)53-37-35(52-39(38(37)49-8)43-25-24-36(45)42-40(43)46)27-50-41(30-14-12-11-13-15-30,31-16-20-33(47-6)21-17-31)32-18-22-34(48-7)23-19-32/h1,11-25,28-29,35,37-39H,10,26-27H2,2-8H3,(H,42,45,46)/t35-,37-,38-,39-,54?/m1/s1
2'-OMe A(Bz) Obutyn-amidite
Description: 2'-OMe A(Bz) Obutyn-amidite is a modified phosphoramidite used in oligonucleotide synthesis. It contains an adenosine nucleoside modified with a 2'-O-methyl (2'-OMe) group and a benzoyl (Bz) group, with a 3-butynyl (Obutyn) group attached to the phosphoramidite moiety. This compound is employed in solid-phase oligonucleotide synthesis to incorporate specifically modified adenosine nucleosides into oligonucleotide sequences. The 2'-O-methyl modification enhances stability, while the benzoyl group serves as a protecting group, and the 3-butynyl group provides a functional handle for further modification. It allows precise control over nucleotide incorporation and subsequent conjugation or labeling reactions.
CAT: BRP-00933
CAS: 1840885-68-8
MF: C49H55N6O8P
MF: 886.99
Purity: >95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: NEFHXUABIXRDHS-HHRUMCNBSA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: O=C(NC1=NC=NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP(OCCC#C)N(C(C)C)C(C)C)C3OC)C=7C=CC=CC7
IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl but-3-yn-1-yl diisopropylphosphoramidite
InChI: InChI=1S/C49H55N6O8P/c1-9-10-29-61-64(55(33(2)3)34(4)5)63-43-41(62-48(44(43)59-8)54-32-52-42-45(50-31-51-46(42)54)53-47(56)35-17-13-11-14-18-35)30-60-49(36-19-15-12-16-20-36,37-21-25-39(57-6)26-22-37)38-23-27-40(58-7)28-24-38/h1,11-28,31-34,41,43-44,48H,10,29-30H2,2-8H3,(H,50,51,53,56)/t41-,43-,44-,48-,64?/m1/s1
Synonyms: Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[3-butyn-1-yl N,N-bis(1-methylethyl)phosphoramidite]
2'-OMe G(iBu) Obutyn-amidite
Description: 2'-OMe G(iBu) Obutyn-amidite is a modified phosphoramidite used in oligonucleotide synthesis. It contains a guanosine nucleoside modified with a 2'-O-methyl (2'-OMe) group and an isobutyl (iBu) group. This compound is utilized in solid-phase oligonucleotide synthesis to introduce specifically modified guanosine nucleosides into oligonucleotide sequences. The 2'-O-methyl modification enhances stability, while the isobutyl group serves as a protecting group, and the 3-butynyl group provides a functional handle for further modification. It allows precise control over nucleotide incorporation and subsequent conjugation or labeling reactions.
CAT: BRP-00934
CAS: 1773534-68-1
MF: C46H57N6O9P
MF: 868.97
Purity: >97%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: BIFMOLDNUGOVBS-DMWBDYODSA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: O=C1N=C(NC(=O)C(C)C)NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP(OCCC#C)N(C(C)C)C(C)C)C3OC
IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl but-3-yn-1-yl diisopropylphosphoramidite
InChI: InChI=1S/C46H57N6O9P/c1-11-12-26-59-62(52(30(4)5)31(6)7)61-39-37(60-44(40(39)57-10)51-28-47-38-41(51)48-45(50-43(38)54)49-42(53)29(2)3)27-58-46(32-16-14-13-15-17-32,33-18-22-35(55-8)23-19-33)34-20-24-36(56-9)25-21-34/h1,13-25,28-31,37,39-40,44H,12,26-27H2,2-10H3,(H2,48,49,50,53,54)/t37-,39-,40-,44-,62?/m1/s1
Synonyms: Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-N-(2-methyl-1-oxopropyl)-, 3'-[3-butyn-1-yl N,N-bis(1-methylethyl)phosphoramidite]
2'-OMe U OMe-amidite
Description: 2'-OMe U OMe-amidite is a reagent commonly used in oligonucleotide synthesis. It involves a methyl (Me) group at the 2' position of ribose and incorporates a methoxy (OMe) group directly linked to the phosphoramidite moiety. This allows for the controlled synthesis of modified oligonucleotides with improved stability and specific functionalities.
CAT: BRP-00935
CAS: 110764-77-7
MF: C38H48N3O9P
MF: 721.79
Purity: >95%
Appearance: White, off-white to faint yellow powder
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Storage: Store at -20 °C
InChIKey: ZFAYUVCJJLJWPV-KQBWMQIQSA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: O=C1C=CN(C(=O)N1)C2OC(COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)C(OP(OC)N(C(C)C)C(C)C)C2OC
IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl methyl diisopropylphosphoramidite
InChI: InChI=1S/C38H48N3O9P/c1-25(2)41(26(3)4)51(47-8)50-34-32(49-36(35(34)46-7)40-23-22-33(42)39-37(40)43)24-48-38(27-12-10-9-11-13-27,28-14-18-30(44-5)19-15-28)29-16-20-31(45-6)21-17-29/h9-23,25-26,32,34-36H,24H2,1-8H3,(H,39,42,43)/t32-,34-,35-,36-,51?/m1/s1
Synonyms: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[methyl bis(1-methylethyl)phosphoramidite]; 5'-O-DMTr-2'-OMe-U-3'-Methoxy-phosphoramidite; 5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyl-uridine-3'-Methoxy-phosphoramidite
2'-OMe A(Bz) OMe-amidite
Description: 2'-OMe A(Bz) OMe-amidite is a reagent used in oligonucleotide synthesis. It features a methyl (Me) group at the 2' position of ribose, adenine (A) possibly protected with a benzoyl (Bz) group, and incorporates a methoxy (OMe) group directly linked to the phosphoramidite moiety. This facilitates the controlled synthesis of modified oligonucleotides with improved stability and specific functionalities.
CAT: BRP-00936
CAS: 110782-30-4
MF: C46H53N6O8P
MF: 848.94
Purity: >95%
Appearance: White, off-white to faint yellow powder
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Storage: Store at -20 °C
InChIKey: LZPPZAAMMANQFD-HLVGMPGCSA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: O=C(NC1=NC=NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP(OC)N(C(C)C)C(C)C)C3OC)C=7C=CC=CC7
IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl methyl diisopropylphosphoramidite
InChI: InChI=1S/C46H53N6O8P/c1-30(2)52(31(3)4)61(57-8)60-40-38(59-45(41(40)56-7)51-29-49-39-42(47-28-48-43(39)51)50-44(53)32-15-11-9-12-16-32)27-58-46(33-17-13-10-14-18-33,34-19-23-36(54-5)24-20-34)35-21-25-37(55-6)26-22-35/h9-26,28-31,38,40-41,45H,27H2,1-8H3,(H,47,48,50,53)/t38-,40-,41-,45-,61?/m1/s1
Synonyms: Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[methyl bis(1-methylethyl)phosphoramidite]; 5'-O-DMTr-2'-OMe-A(Bz)-3'-Methoxy-phosphoramidite; N6-benzoyl-5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyl-Adenosine-3'-Methoxy-phosphoramidite
2'-OMe G(iBu) OMe-amidite
Description: 2'-OMe G(iBu) OMe-amidite is a reagent utilized in oligonucleotide synthesis. It consists of a methyl (Me) group at the 2' position of ribose, guanosine (G) potentially protected with an isobutyl (iBu) group, and incorporates a methoxy (OMe) group directly linked to the phosphoramidite moiety. This enables the controlled synthesis of modified oligonucleotides with enhanced stability and tailored functionalities.
CAT: BRP-00937
CAS: 179478-96-7
MF: C43H55N6O9P
MF: 830.92
Purity: >98%
Appearance: White, off-white to faint yellow powder
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Storage: Store at -20 °C
InChIKey: ABXYOPVUGHRVTD-BFXRUIMDSA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: O=C1N=C(NC(=O)C(C)C)NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP(OC)N(C(C)C)C(C)C)C3OC
IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl methyl diisopropylphosphoramidite
InChI: InChI=1S/C43H55N6O9P/c1-26(2)39(50)46-42-45-38-35(40(51)47-42)44-25-48(38)41-37(54-9)36(58-59(55-10)49(27(3)4)28(5)6)34(57-41)24-56-43(29-14-12-11-13-15-29,30-16-20-32(52-7)21-17-30)31-18-22-33(53-8)23-19-31/h11-23,25-28,34,36-37,41H,24H2,1-10H3,(H2,45,46,47,50,51)/t34-,36-,37-,41-,59?/m1/s1
Synonyms: Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-N-(2-methyl-1-oxopropyl)-, 3'-[methyl bis(1-methylethyl)phosphoramidite]; 5'-O-DMTr-2'-OMe-G(iBu)-3'-Methoxy-phosphoramidite; N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-guanosine-3'-Methoxy-phosphoramidite
2'-MOE MeC(Bz) OMe-amidite
Description: 2'-OMe MeC(Bz) OMe-amidite is a reagent employed in oligonucleotide synthesis. It contains a methyl (Me) group at the 2' position of ribose, cytosine (C) potentially protected with a benzoyl (Bz) group, and incorporates a methoxy (OMe) group directly linked to the phosphoramidite moiety. This facilitates the controlled synthesis of modified oligonucleotides with improved stability and specific functionalities.
CAT: BRP-00938
CAS: 647858-99-9
MF: C48H59N4O10P
MF: 882.99
Purity: >95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: GVNBZSNXLHGONB-AENBYTAOSA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: O=C1N=C(NC(=O)C=2C=CC=CC2)C(=CN1C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP(OC)N(C(C)C)C(C)C)C3OCCOC)C
IUPAC Name: (2R,3R,4R,5R)-5-(4-benzamido-5-methyl-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl methyl diisopropylphosphoramidite
InChI: InChI=1S/C48H59N4O10P/c1-32(2)52(33(3)4)63(58-9)62-42-41(31-60-48(36-18-14-11-15-19-36,37-20-24-39(56-7)25-21-37)38-22-26-40(57-8)27-23-38)61-46(43(42)59-29-28-55-6)51-30-34(5)44(50-47(51)54)49-45(53)35-16-12-10-13-17-35/h10-27,30,32-33,41-43,46H,28-29,31H2,1-9H3,(H,49,50,53,54)/t41-,42-,43-,46-,63?/m1/s1
Synonyms: Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-5-methyl-, 3'-[methyl bis(1-methylethyl)phosphoramidite]
