Phosphoramidites - RNA / BOC Sciences

DMTr-2'-O-4'-C-ethylene-rG(iBu)-3'-CE-Phosphoramidite

Description: DMTr-2'-O-4'-C-ethylene-rG(iBu)-3'-CE-Phosphoramidite, utilized in oligonucleotide synthesis, features an ethylene linker at the 2'-O and 4'-C positions of guanosine (rG), with isobutyryl (iBu) protection on the guanine amino group. The cyanoethyl (CE) group at the 3'-end facilitates efficient coupling reactions during solid-phase synthesis. This modified nucleotide is valuable for generating RNA sequences with enhanced stability and binding affinity, suitable for applications such as RNA interference (RNAi) and RNA therapeutics.

CAT: BRP-00601

CAS: 287737-58-0

MF: C46H56N7O9P

MF: 881.97

Purity: ≥98%

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InChIKey: VXCXNHPZXAIEDO-DNUXVXCXSA-N

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C4C(C(O3)(CCO4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC)OP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: N-[9-[(1R,5R,7R,8S)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-8-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-2,6-dioxabicyclo[3.2.1]octan-7-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide

InChI: InChI=1S/C46H56N7O9P/c1-29(2)41(54)50-44-49-40-37(42(55)51-44)48-28-52(40)43-38-39(62-63(60-25-12-24-47)53(30(3)4)31(5)6)45(61-43,23-26-58-38)27-59-46(32-13-10-9-11-14-32,33-15-19-35(56-7)20-16-33)34-17-21-36(57-8)22-18-34/h9-11,13-22,28-31,38-39,43H,12,23,25-27H2,1-8H3,(H2,49,50,51,54,55)/t38-,39+,43-,45-,63?/m1/s1

Synonyms: ENA-G(iBu) Phosphoramidite; N-[9-[2,6-Anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-5-deoxy-α-L-lyxo-hexofuranosyl]-6,9-dihydro-6-oxo-1H-purin-2-yl]-2-methylpropanamide; (1R,5R,7R,8S)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-7-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-2,6-dioxabicyclo[3.2.1]octan-8-yl (2-cyanoethyl) diisopropylphosphoramidite

DMTr-2'-O-C22-rA(Bz)-3'-CE-Phosphoramidite

Description: DMTr-2'-O-C22-rA(Bz)-3'-CE-Phosphoramidite, utilized in oligonucleotide synthesis, contains a DMTr protecting group at the 5'-position and a cyanoethyl (CE) group at the 3'-end. The nucleoside unit is adenosine (rA), modified with a C22 linker at the 2'-O position and benzoyl (Bz) protection on the adenine amino group. It is employed in the synthesis of RNA sequences with enhanced stability and binding affinity, suitable for various research applications including RNA-based therapy and gene expression modulation.

CAT: BRP-00603

CAS: 2923115-67-5

MF: C69H96N7O8P

MF: 1182.54

Purity: ≥98%

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InChIKey: BCBFIURHCBIJCZ-GOQGTMNZSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C(=NC=NC32)NC(=O)C=4C=CC=CC4)C1OCCCCCCCCCCCCCCCCCCCCCC)COC(C=5C=CC=CC5)(C6=CC=C(OC)C=C6)C7=CC=C(OC)C=C7)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(docosyloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C69H96N7O8P/c1-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26-33-48-80-64-63(84-85(82-49-34-47-70)76(53(2)3)54(4)5)61(83-68(64)75-52-73-62-65(71-51-72-66(62)75)74-67(77)55-35-29-27-30-36-55)50-81-69(56-37-31-28-32-38-56,57-39-43-59(78-6)44-40-57)58-41-45-60(79-7)46-42-58/h27-32,35-46,51-54,61,63-64,68H,8-26,33-34,48-50H2,1-7H3,(H,71,72,74,77)/t61-,63-,64-,68-,85?/m1/s1

5'-O-DMT-2'-O-MOE-rG(iBu)-3'-((2-cyanoethoxy)(diisopropylamino)phosphoramidite)-ethyl-diisopropylphosphoramidite

Description: 5'-O-DMT-2'-O-MOE-rG(iBu)-3'-((2-cyanoethoxy)(diisopropylamino)phosphoramidite)-ethyl-diisopropylphosphoramidite, utilized in oligonucleotide synthesis, features a 5'-O-DMT protecting group and contains a diisopropylamino group for coupling with the next nucleotide. The nucleoside unit is guanosine (rG), modified with a 2'-O-methoxyethyl (MOE) group and isobutyryl (iBu) protection on the guanine amino group. It also contains a phosphoramidite group for solid-phase synthesis. It finds application in the construction of RNA sequences with enhanced stability and target specificity, suitable for various research applications including RNA-based therapeutics and gene editing.

CAT: BRP-00604

MF: C55H78N8O12P2

MF: 1105.22

Purity: ≥98%

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InChIKey: LVJZCNKMRFOXEH-XOHXKFSOSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl (2-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)ethyl) diisopropylphosphoramidite

InChI: InChI=1S/C55H78N8O12P2/c1-36(2)51(64)59-54-58-50-47(52(65)60-54)57-35-61(50)53-49(69-31-30-66-11)48(75-77(63(39(7)8)40(9)10)73-33-32-72-76(71-29-17-28-56)62(37(3)4)38(5)6)46(74-53)34-70-55(41-18-15-14-16-19-41,42-20-24-44(67-12)25-21-42)43-22-26-45(68-13)27-23-43/h14-16,18-27,35-40,46,48-49,53H,17,29-34H2,1-13H3,(H2,58,59,60,64,65)/t46-,48-,49-,53-,76?,77?/m1/s1

5'-O-DMT-2'-O-MOE-5-Me-rC(Bz)-3'-((2-cyanoethoxy)(diisopropylamino)phosphoramidite)-ethyl-diisopropylphosphoramidite

Description: 5'-O-DMT-2'-O-MOE-5-Me-rC(Bz)-3'-((2-cyanoethoxy)(diisopropylamino)phosphoramidite)-ethyl-diisopropylphosphoramidite, employed in oligonucleotide synthesis, features a 5'-O-DMT protecting group and contains a diisopropylamino group for coupling with the next nucleotide. The nucleoside unit is 5-methylcytidine (5-Me-rC), modified with a 2'-O-methoxyethyl (MOE) group and benzoyl (Bz) protection on the cytosine amino group. Additionally, it contains a phosphoramidite group for solid-phase synthesis. The presence of a cyanoethoxy group at the 3'-end facilitates efficient coupling reactions during synthesis. This compound is valuable in generating modified RNA sequences with enhanced stability and target specificity, suitable for various research applications including RNA-based therapeutics and gene editing.

CAT: BRP-00605

MF: C58H78N6O12P2

MF: 1113.24

Purity: ≥98%

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InChIKey: GEBJJSSJUVBPKC-UBMNREJOSA-N

IUPAC Name: (2R,3R,4R,5R)-5-(4-benzamido-5-methyl-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl (2-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)ethyl) diisopropylphosphoramidite

InChI: InChI=1S/C58H78N6O12P2/c1-40(2)63(41(3)4)77(72-33-19-32-59)73-36-37-74-78(64(42(5)6)43(7)8)76-52-51(39-71-58(46-22-17-14-18-23-46,47-24-28-49(68-11)29-25-47)48-26-30-50(69-12)31-27-48)75-56(53(52)70-35-34-67-10)62-38-44(9)54(61-57(62)66)60-55(65)45-20-15-13-16-21-45/h13-18,20-31,38,40-43,51-53,56H,19,33-37,39H2,1-12H3,(H,60,61,65,66)/t51-,52-,53-,56-,77?,78?/m1/s1

ethane-1,2-di(5'-O-DMTr-2'-O-MOE-5-Me-rC(Bz)-3'-oxy)-bis(diisopropylphosphoramidite)

Description: ethane-1,2-di(5'-O-DMTr-2'-O-MOE-5-Me-rC(Bz)-3'-oxy)-bis(diisopropylphosphoramidite) is employed in the solid-phase synthesis of oligonucleotides with specific modifications, enhancing their stability and target affinity for applications in molecular biology and biotechnology.

CAT: BRP-00606

MF: C96H116N8O20P2

MF: 1763.97

Purity: ≥92%

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InChIKey: ZRLNUNRPDXULMT-SUWRQQMKSA-N

IUPAC Name: bis((2R,3R,4R,5R)-5-(4-benzamido-5-methyl-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl) ethane-1,2-diyl bis(diisopropylphosphoramidite)

InChI: InChI=1S/C96H116N8O20P2/c1-63(2)103(64(3)4)125(123-83-81(61-117-95(71-33-25-19-26-34-71,73-37-45-77(111-13)46-38-73)74-39-47-78(112-14)48-40-74)121-91(85(83)115-55-53-109-11)101-59-67(9)87(99-93(101)107)97-89(105)69-29-21-17-22-30-69)119-57-58-120-126(104(65(5)6)66(7)8)124-84-82(62-118-96(72-35-27-20-28-36-72,75-41-49-79(113-15)50-42-75)76-43-51-80(114-16)52-44-76)122-92(86(84)116-56-54-110-12)102-60-68(10)88(100-94(102)108)98-90(106)70-31-23-18-24-32-70/h17-52,59-60,63-66,81-86,91-92H,53-58,61-62H2,1-16H3,(H,97,99,105,107)(H,98,100,106,108)/t81-,82-,83-,84-,85-,86-,91-,92-,125?,126?/m1/s1

ethane-1,2-di(5'-O-DMTr-2'-O-MOE-rA(Bz)-3'-oxy)-bis(diisopropylphosphoramidite)

Description: ethane-1,2-di(5'-O-DMTr-2'-O-MOE-rA(Bz)-3'-oxy)-bis(diisopropylphosphoramidite) is utilized in the solid-phase synthesis of oligonucleotides with specific modifications, enhancing their stability and target affinity for applications in molecular biology and biotechnology.

CAT: BRP-00607

MF: C96H112N12O18P2

MF: 1783.97

Purity: ≥92%

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InChIKey: JUHDGWSQBXOHFV-IFGMRGENSA-N

IUPAC Name: bis((2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl) ethane-1,2-diyl bis(diisopropylphosphoramidite)

InChI: InChI=1S/C96H112N12O18P2/c1-63(2)107(64(3)4)127(125-83-79(57-119-95(69-31-23-17-24-32-69,71-35-43-75(113-11)44-36-71)72-37-45-76(114-12)46-38-72)123-93(85(83)117-53-51-111-9)105-61-101-81-87(97-59-99-89(81)105)103-91(109)67-27-19-15-20-28-67)121-55-56-122-128(108(65(5)6)66(7)8)126-84-80(58-120-96(70-33-25-18-26-34-70,73-39-47-77(115-13)48-40-73)74-41-49-78(116-14)50-42-74)124-94(86(84)118-54-52-112-10)106-62-102-82-88(98-60-100-90(82)106)104-92(110)68-29-21-16-22-30-68/h15-50,59-66,79-80,83-86,93-94H,51-58H2,1-14H3,(H,97,99,103,109)(H,98,100,104,110)/t79-,80-,83-,84-,85-,86-,93-,94-,127?,128?/m1/s1

ethane-1,2-di(5'-O-DMTr-2'-O-MOE-rG(iBu)-3'-oxy)-bis(diisopropylphosphoramidite)

Description: ethane-1,2-di(5'-O-DMTr-2'-O-MOE-rG(iBu)-3'-oxy)-bis(diisopropylphosphoramidite) is employed in the solid-phase synthesis of oligonucleotides with specific modifications, enhancing their stability and target affinity for applications in molecular biology and biotechnology.

CAT: BRP-00608

MF: C90H116N12O20P2

MF: 1747.93

Purity: ≥92%

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InChIKey: DJTWFMQESYMPJM-FHQSMYATSA-N

IUPAC Name: bis((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl) ethane-1,2-diyl bis(diisopropylphosphoramidite)

InChI: InChI=1S/C90H116N12O20P2/c1-55(2)81(103)95-87-93-79-73(83(105)97-87)91-53-99(79)85-77(113-47-45-107-13)75(71(119-85)51-115-89(61-25-21-19-22-26-61,63-29-37-67(109-15)38-30-63)64-31-39-68(110-16)40-32-64)121-123(101(57(5)6)58(7)8)117-49-50-118-124(102(59(9)10)60(11)12)122-76-72(120-86(78(76)114-48-46-108-14)100-54-92-74-80(100)94-88(98-84(74)106)96-82(104)56(3)4)52-116-90(62-27-23-20-24-28-62,65-33-41-69(111-17)42-34-65)66-35-43-70(112-18)44-36-66/h19-44,53-60,71-72,75-78,85-86H,45-52H2,1-18H3,(H2,93,95,97,103,105)(H2,94,96,98,104,106)/t71-,72-,75-,76-,77-,78-,85-,86-,123?,124?/m1/s1

di(5'-O-DMTr-2'-O-MOE-rG(iBu)-3'-oxy)-(oxybis(ethane-1,2-diyl))-bis(diisopropylphosphoramidite)

Description: di(5'-O-DMTr-2'-O-MOE-rG(iBu)-3'-oxy)-(oxybis(ethane-1,2-diyl))-bis(diisopropylphosphoramidite) consists of two molecules of 5'-O-DMTr-2'-O-MOE-rG(iBu)-3'-oxy connected by an ethane-1,2-diyl linker, with each end functionalized with a diisopropylphosphoramidite group. The guanosine (rG) nucleoside units are modified with a 2'-O-methoxyethyl (MOE) group and isobutyryl (iBu) protection on the guanine amino group. This compound is utilized in oligonucleotide synthesis for the introduction of guanosine modifications, enhancing stability and target specificity in RNA sequences.

CAT: BRP-00609

MF: C92H120N12O21P2

MF: 1791.98

Purity: ≥92%

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InChIKey: MSPWBBNFOKRACO-QBSMUBNASA-N

InChI: InChI=1S/C92H120N12O21P2/c1-57(2)83(105)97-89-95-81-75(85(107)99-89)93-55-101(81)87-79(116-49-45-109-13)77(73(122-87)53-118-91(63-25-21-19-22-26-63,65-29-37-69(111-15)38-30-65)66-31-39-70(112-16)40-32-66)124-126(103(59(5)6)60(7)8)120-51-47-115-48-52-121-127(104(61(9)10)62(11)12)125-78-74(123-88(80(78)117-50-46-110-14)102-56-94-76-82(102)96-90(100-86(76)108)98-84(106)58(3)4)54-119-92(64-27-23-20-24-28-64,67-33-41-71(113-17)42-34-67)68-35-43-72(114-18)44-36-68/h19-44,55-62,73-74,77-80,87-88H,45-54H2,1-18H3,(H2,95,97,99,105,107)(H2,96,98,100,106,108)/t73-,74-,77-,78-,79-,80-,87-,88-,126?,127?/m1/s1

di(5'-O-DMTr-2'-O-MOE-rA(Bz)-3'-oxy)-(oxybis(ethane-1,2-diyl))-bis(diisopropylphosphoramidite)

Description: di(5'-O-DMTr-2'-O-MOE-rA(Bz)-3'-oxy)-(oxybis(ethane-1,2-diyl))-bis(diisopropylphosphoramidite) contains two molecules of 5'-O-DMTr-2'-O-MOE-rA(Bz)-3'-oxy linked by an ethane-1,2-diyl linker, with each end capped with a diisopropylphosphoramidite group. The adenosine (rA) nucleoside units are modified with a 2'-O-methoxyethyl (MOE) group and benzoyl (Bz) protection on the adenine amino group. It is employed in oligonucleotide synthesis to incorporate adenosine modifications, enhancing stability and target affinity in RNA sequences.

CAT: BRP-00610

MF: C98H116N12O19P2

MF: 1828.02

Purity: ≥92%

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InChIKey: HYMLNNFAMXTLQA-DEYJQIQZSA-N

InChI: InChI=1S/C98H116N12O19P2/c1-65(2)109(66(3)4)130(128-85-81(59-122-97(71-31-23-17-24-32-71,73-35-43-77(115-11)44-36-73)74-37-45-78(116-12)46-38-74)126-95(87(85)120-55-51-113-9)107-63-103-83-89(99-61-101-91(83)107)105-93(111)69-27-19-15-20-28-69)124-57-53-119-54-58-125-131(110(67(5)6)68(7)8)129-86-82(60-123-98(72-33-25-18-26-34-72,75-39-47-79(117-13)48-40-75)76-41-49-80(118-14)50-42-76)127-96(88(86)121-56-52-114-10)108-64-104-84-90(100-62-102-92(84)108)106-94(112)70-29-21-16-22-30-70/h15-50,61-68,81-82,85-88,95-96H,51-60H2,1-14H3,(H,99,101,105,111)(H,100,102,106,112)/t81-,82-,85-,86-,87-,88-,95-,96-,130?,131?/m1/s1

di(5'-O-DMTr-2'-O-MOE-5-Me-rC(Bz)-3'-oxy)-(oxybis(ethane-1,2-diyl))-bis(diisopropylphosphoramidite)

Description: di(5'-O-DMTr-2'-O-MOE-5-Me-rC(Bz)-3'-oxy)-(oxybis(ethane-1,2-diyl))-bis(diisopropylphosphoramidite) features two molecules of 5'-O-DMTr-2'-O-MOE-5-Me-rC(Bz)-3'-oxy connected by an ethane-1,2-diyl linker, with each end bearing a diisopropylphosphoramidite group. The 5-methylcytidine (5-Me-rC) nucleoside units are modified with a 2'-O-methoxyethyl (MOE) group and benzoyl (Bz) protection on the cytosine amino group. It is utilized in oligonucleotide synthesis for introducing modified cytidine residues, enhancing stability and target specificity in RNA sequences.

CAT: BRP-00611

MF: C98H120N8O21P2

MF: 1808.02

Purity: ≥92%

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InChIKey: JOFMESXERKIMQK-AFYKGNOXSA-N

InChI: InChI=1S/C98H120N8O21P2/c1-65(2)105(66(3)4)128(126-85-83(63-120-97(73-33-25-19-26-34-73,75-37-45-79(113-13)46-38-75)76-39-47-80(114-14)48-40-76)124-93(87(85)118-57-53-111-11)103-61-69(9)89(101-95(103)109)99-91(107)71-29-21-17-22-30-71)122-59-55-117-56-60-123-129(106(67(5)6)68(7)8)127-86-84(64-121-98(74-35-27-20-28-36-74,77-41-49-81(115-15)50-42-77)78-43-51-82(116-16)52-44-78)125-94(88(86)119-58-54-112-12)104-62-70(10)90(102-96(104)110)100-92(108)72-31-23-18-24-32-72/h17-52,61-62,65-68,83-88,93-94H,53-60,63-64H2,1-16H3,(H,99,101,107,109)(H,100,102,108,110)/t83-,84-,85-,86-,87-,88-,93-,94-,128?,129?/m1/s1

Bis(5'-O-DMTr-2'-O-MOE-5-Me-rC(Bz)-3'-oxy)-diisopropylphosphoramidite

Description: Bis(5'-O-DMTr-2'-O-MOE-5-Me-rC(Bz)-3'-oxy)-diisopropylphosphoramidite consists of two molecules of 5'-O-DMTr-2'-O-MOE-5-Me-rC(Bz)-3'-oxy linked by a diisopropylphosphoramidite group. Each 5'-O-DMTr-2'-O-MOE-5-Me-rC(Bz)-3'-oxy unit is equipped with a diisopropylphosphoramidite group, facilitating its integration into oligonucleotide synthesis. It is used to introduce modified 5-methylcytidine (5-Me-rC) residues into RNA sequences, enhancing stability and target specificity.

CAT: BRP-00612

MF: C88H98N7O18P

MF: 1572.73

Purity: ≥92%

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InChIKey: SISSXAOEXVVHFI-QEZASILESA-N

IUPAC Name: bis((2R,3R,4R,5R)-5-(4-benzamido-5-methyl-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl) diisopropylphosphoramidite

InChI: InChI=1S/C88H98N7O18P/c1-57(2)95(58(3)4)114(112-75-73(55-108-87(63-29-21-15-22-30-63,65-33-41-69(102-9)42-34-65)66-35-43-70(103-10)44-36-66)110-83(77(75)106-51-49-100-7)93-53-59(5)79(91-85(93)98)89-81(96)61-25-17-13-18-26-61)113-76-74(56-109-88(64-31-23-16-24-32-64,67-37-45-71(104-11)46-38-67)68-39-47-72(105-12)48-40-68)111-84(78(76)107-52-50-101-8)94-54-60(6)80(92-86(94)99)90-82(97)62-27-19-14-20-28-62/h13-48,53-54,57-58,73-78,83-84H,49-52,55-56H2,1-12H3,(H,89,91,96,98)(H,90,92,97,99)/t73-,74-,75-,76-,77-,78-,83-,84-/m1/s1

Bis(5'-O-DMTr-2'-O-MOE-rG(iBu)-3'-oxy)-diisopropylphosphoramidite

Description: Bis(5'-O-DMTr-2'-O-MOE-rG(iBu)-3'-oxy)-diisopropylphosphoramidite comprises two molecules of 5'-O-DMTr-2'-O-MOE-rG(iBu)-3'-oxy linked by a diisopropylphosphoramidite group. Each 5'-O-DMTr-2'-O-MOE-rG(iBu)-3'-oxy unit is equipped with a diisopropylphosphoramidite group, facilitating its integration into oligonucleotide synthesis. It is utilized to introduce modified guanosine (rG) residues into RNA sequences, enhancing stability and target specificity.

CAT: BRP-00613

MF: C82H98N11O18P

MF: 1556.72

Purity: ≥92%

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InChIKey: BXMZUGBTEMISAL-APUMCEBKSA-N

InChI: InChI=1S/C82H98N11O18P/c1-49(2)73(94)87-79-85-71-65(75(96)89-79)83-47-91(71)77-69(104-43-41-98-9)67(63(108-77)45-106-81(53-21-17-15-18-22-53,55-25-33-59(100-11)34-26-55)56-27-35-60(101-12)36-28-56)110-112(93(51(5)6)52(7)8)111-68-64(109-78(70(68)105-44-42-99-10)92-48-84-66-72(92)86-80(90-76(66)97)88-74(95)50(3)4)46-107-82(54-23-19-16-20-24-54,57-29-37-61(102-13)38-30-57)58-31-39-62(103-14)40-32-58/h15-40,47-52,63-64,67-70,77-78H,41-46H2,1-14H3,(H2,85,87,89,94,96)(H2,86,88,90,95,97)/t63-,64-,67-,68-,69-,70-,77-,78-/m1/s1

Bis(5'-O-DMTr-2'-O-MOE-rA(Bz)-3'-oxy)-diisopropylphosphoramidite

Description: Bis(5'-O-DMTr-2'-O-MOE-rA(Bz)-3'-oxy)-diisopropylphosphoramidite consists of two molecules of 5'-O-DMTr-2'-O-MOE-rA(Bz)-3'-oxy linked by a diisopropylphosphoramidite group. Each 5'-O-DMTr-2'-O-MOE-rA(Bz)-3'-oxy unit is equipped with a diisopropylphosphoramidite group, facilitating its integration into oligonucleotide synthesis. It is used to introduce modified adenosine (rA) residues into RNA sequences, enhancing stability and target specificity.

CAT: BRP-00614

MF: C88H94N11O16P

MF: 1592.75

Purity: ≥92%

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InChIKey: SSMWHJUZANQYIO-BDXQTOLXSA-N

IUPAC Name: bis((2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl) diisopropylphosphoramidite

InChI: InChI=1S/C88H94N11O16P/c1-57(2)99(58(3)4)116(114-75-71(51-110-87(61-27-19-13-20-28-61,63-31-39-67(104-7)40-32-63)64-33-41-68(105-8)42-34-64)112-85(77(75)108-49-47-102-5)97-55-93-73-79(89-53-91-81(73)97)95-83(100)59-23-15-11-16-24-59)115-76-72(52-111-88(62-29-21-14-22-30-62,65-35-43-69(106-9)44-36-65)66-37-45-70(107-10)46-38-66)113-86(78(76)109-50-48-103-6)98-56-94-74-80(90-54-92-82(74)98)96-84(101)60-25-17-12-18-26-60/h11-46,53-58,71-72,75-78,85-86H,47-52H2,1-10H3,(H,89,91,95,100)(H,90,92,96,101)/t71-,72-,75-,76-,77-,78-,85-,86-/m1/s1

DMTr-2'-O-EOE-rA(Bz)-3'-CE-Phosphoramidite

Description: DMTr-2'-O-EOE-rA(Bz)-3'-CE-Phosphoramidite is used in oligonucleotide synthesis and contains a 2'-O-ethoxyethyl (EOE) group at the 2'-position of adenosine (rA), along with benzoyl (Bz) protection on the adenine amino group. Additionally, it features a cyanoethyl (CE) group at the 3'-end to facilitate efficient coupling reactions during solid-phase synthesis. It is employed to introduce modified adenosine residues into RNA sequences, enhancing stability and target specificity.

CAT: BRP-00615

MF: C51H60N7O9P

MF: 946.05

Purity: ≥95%

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InChIKey: FXYAXMLJVORSBX-SXQANJJUSA-N

CanonicalSMILES: CCOCCOC1C(C(OC1N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC)OP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-(2-ethoxyethoxy)oxolan-2-yl]purin-6-yl]benzamide

InChI: InChI=1S/C51H60N7O9P/c1-8-62-30-31-63-46-45(67-68(65-29-15-28-52)58(35(2)3)36(4)5)43(66-50(46)57-34-55-44-47(53-33-54-48(44)57)56-49(59)37-16-11-9-12-17-37)32-64-51(38-18-13-10-14-19-38,39-20-24-41(60-6)25-21-39)40-22-26-42(61-7)27-23-40/h9-14,16-27,33-36,43,45-46,50H,8,15,29-32H2,1-7H3,(H,53,54,56,59)/t43-,45-,46-,50-,68?/m1/s1

Synonyms: (2R,3R,4R,5R)-5-(6-Benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-ethoxyethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

DMTr-2'-O-EOE-rG(iBu)-3'-CE-Phosphoramidite

Description: DMTr-2'-O-EOE-rG(iBu)-3'-CE-Phosphoramidite, utilized in oligonucleotide synthesis, features a 2'-O-ethoxyethyl (EOE) group at the 2'-position of guanosine (rG), with isobutyryl (iBu) protection on the guanine amino group. It also contains a cyanoethyl (CE) group at the 3'-end to facilitate efficient coupling reactions during solid-phase synthesis. It is employed to introduce modified guanosine residues into RNA sequences, enhancing stability and target specificity.

CAT: BRP-00616

CAS: 2253990-02-0

MF: C48H62N7O10P

MF: 928.04

Purity: ≥95%

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InChIKey: FIYLELGPQAAWKS-USWYRWCRSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C(=O)N=C(NC(=O)C(C)C)NC32)C1OCCOCC)COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-ethoxyethoxy)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C48H62N7O10P/c1-10-60-27-28-61-42-41(65-66(63-26-14-25-49)55(32(4)5)33(6)7)39(64-46(42)54-30-50-40-43(54)51-47(53-45(40)57)52-44(56)31(2)3)29-62-48(34-15-12-11-13-16-34,35-17-21-37(58-8)22-18-35)36-19-23-38(59-9)24-20-36/h11-13,15-24,30-33,39,41-42,46H,10,14,26-29H2,1-9H3,(H2,51,52,53,56,57)/t39-,41-,42-,46-,66?/m1/s1

DMTr-2'-O-EOE-5-Me-rC(Bz)-3'-CE-Phosphoramidite

Description: DMTr-2'-O-EOE-5-Me-rC(Bz)-3'-CE-Phosphoramidite is utilized in oligonucleotide synthesis and contains a 2'-O-ethoxyethyl (EOE) group at the 2'-position of 5-methylcytidine (5-Me-rC), along with benzoyl (Bz) protection on the cytosine amino group. Additionally, it features a cyanoethyl (CE) group at the 3'-end to facilitate efficient coupling reactions during solid-phase synthesis. It is employed to introduce modified 5-methylcytidine residues into RNA sequences, enhancing stability and target specificity.

CAT: BRP-00617

MF: C51H62N5O10P

MF: 936.06

Purity: ≥95%

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InChIKey: GFURHQMVDLZCAG-JMTVAXSASA-N

IUPAC Name: (2R,3R,4R,5R)-5-(4-benzamido-5-methyl-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-ethoxyethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C51H62N5O10P/c1-9-61-31-32-62-46-45(66-67(64-30-16-29-52)56(35(2)3)36(4)5)44(65-49(46)55-33-37(6)47(54-50(55)58)53-48(57)38-17-12-10-13-18-38)34-63-51(39-19-14-11-15-20-39,40-21-25-42(59-7)26-22-40)41-23-27-43(60-8)28-24-41/h10-15,17-28,33,35-36,44-46,49H,9,16,30-32,34H2,1-8H3,(H,53,54,57,58)/t44-,45-,46-,49-,67?/m1/s1

DMTr-3'-O-MOE-5-Me-rC(Bz)-2'-CE-Phosphoramidite

Description: DMTr-3'-O-MOE-5-Me-rC(Bz)-2'-CE-Phosphoramidite is used in oligonucleotide synthesis and contains a 3'-O-methoxyethyl (MOE) group at the 3'-position of 5-methylcytidine (5-Me-rC), with benzoyl (Bz) protection on the cytosine amino group. Additionally, it features a cyanoethyl (CE) group at the 2'-end to facilitate efficient coupling reactions during solid-phase synthesis. It is employed to introduce modified 5-methylcytidine residues into RNA sequences, enhancing stability and target specificity.

CAT: BRP-00618

CAS: 1098233-10-3

MF: C50H60N5O10P

MF: 922.03

Purity: ≥95%

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InChIKey: GOMXXEFGGBGLGJ-GICDFOIUSA-N

CanonicalSMILES: CC1=CN(C(=O)N=C1NC(=O)C2=CC=CC=C2)C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OCCOC)OP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-4-(2-methoxyethoxy)oxolan-2-yl]-5-methyl-2-oxopyrimidin-4-yl]benzamide

InChI: InChI=1S/C50H60N5O10P/c1-34(2)55(35(3)4)66(63-29-15-28-51)65-45-44(61-31-30-58-6)43(64-48(45)54-32-36(5)46(53-49(54)57)52-47(56)37-16-11-9-12-17-37)33-62-50(38-18-13-10-14-19-38,39-20-24-41(59-7)25-21-39)40-22-26-42(60-8)27-23-40/h9-14,16-27,32,34-35,43-45,48H,15,29-31,33H2,1-8H3,(H,52,53,56,57)/t43-,44-,45-,48-,66?/m1/s1

Synonyms: 3'-O-MOE-5Me-C(Bz)-2'-phosphoramidite; N4-Bz-5'-O-DMTr-3'-O-(2-methoxyethyl)-5-methyl cytidine-2'-CED-phosphoramidite; Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-(2-methoxyethyl)-5-methyl-, 2'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

DMTr-3'-O-MOE-rA(Bz)-2'-CE-Phosphoramidite

Description: DMTr-3'-O-MOE-rA(Bz)-2'-CE-Phosphoramidite, utilized in oligonucleotide synthesis, features a 3'-O-methoxyethyl (MOE) group at the 3'-position of adenosine (rA), with benzoyl (Bz) protection on the adenine amino group. It also contains a cyanoethyl (CE) group at the 2'-end to facilitate efficient coupling reactions during solid-phase synthesis. It is employed to introduce modified adenosine residues into RNA sequences, enhancing stability and target specificity.

CAT: BRP-00619

CAS: 256224-01-8

MF: C50H58N7O9P

MF: 932.03

Purity: ≥95%

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InChIKey: FODCLDRFHMYZMX-HDMAWCRFSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(C(OC1N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC)OCCOC

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-4-(2-methoxyethoxy)oxolan-2-yl]purin-6-yl]benzamide

InChI: InChI=1S/C50H58N7O9P/c1-34(2)57(35(3)4)67(64-28-14-27-51)66-45-44(62-30-29-59-5)42(65-49(45)56-33-54-43-46(52-32-53-47(43)56)55-48(58)36-15-10-8-11-16-36)31-63-50(37-17-12-9-13-18-37,38-19-23-40(60-6)24-20-38)39-21-25-41(61-7)26-22-39/h8-13,15-26,32-35,42,44-45,49H,14,28-31H2,1-7H3,(H,52,53,55,58)/t42-,44-,45-,49-,67?/m1/s1

Synonyms: 3'-O-MOE-A(Bz)-2'-CED-phosphoramidite; (2R,3R,4R,5R)-2-(6-Benzamido-9H-purin-9-yl)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-(2-methoxyethyl)-, 2'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; N6-Bz-5'-O-DMTr-3'-O-(2-methoxyethyl) adenosine-2'-CED-phosphoramidite

DMTr-3'-O-MOE-rG(iBu)-2'-CE-Phosphoramidite

Description: DMTr-3'-O-MOE-rG(iBu)-2'-CE-Phosphoramidite is utilized in oligonucleotide synthesis and contains a 3'-O-methoxyethyl (MOE) group at the 3'-position of guanosine (rG), with isobutyryl (iBu) protection on the guanine amino group. Additionally, it features a cyanoethyl (CE) group at the 2'-end to facilitate efficient coupling reactions during solid-phase synthesis. It is employed to introduce modified guanosine residues into RNA sequences, enhancing stability and target specificity.

CAT: BRP-00620

CAS: 256224-06-3

MF: C47H60N7O10P

MF: 914.01

Purity: ≥95%

Appearance: White to off-white foam solid

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InChIKey: BWLKVJLYUDLOLH-SBCRAQIVSA-N

Solubility: Soluble in Acetone, Chloroform, DMSO, Ethanol, Methanol

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OCCOC)OP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-4-(2-methoxyethoxy)oxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide

InChI: InChI=1S/C47H60N7O10P/c1-30(2)43(55)51-46-50-42-39(44(56)52-46)49-29-53(42)45-41(64-65(62-25-13-24-48)54(31(3)4)32(5)6)40(60-27-26-57-7)38(63-45)28-61-47(33-14-11-10-12-15-33,34-16-20-36(58-8)21-17-34)35-18-22-37(59-9)23-19-35/h10-12,14-23,29-32,38,40-41,45H,13,25-28H2,1-9H3,(H2,50,51,52,55,56)/t38-,40-,41-,45-,65?/m1/s1

Synonyms: 3'-O-MOE-G(iBu)-2'-phosphoramidite; 5'-O-DMTr-N2-iso-butyroyl-3'-O-(2-methoxyethyl)guanosine-2'-CED-phosphoramidite; Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-(2-methoxyethyl)-N-(2-methyl-1-oxopropyl)-, 2'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; 5'-O-(4,4'-Dimethoxytrityl)-N2-iso-butyroyl-3'-O-(2-methoxyethyl)guanosine-2'-O-[(2-cyanoethyl)(N,N-diisopropyl)]phosphoramidite

DMTr-2'-O-MOEOE-5-Me-rC(Bz)-3'-CE-Phosphoramidite

Description: DMTr-2'-O-MOEOE-5-Me-rC(Bz)-3'-CE-Phosphoramidite, employed in oligonucleotide synthesis, features a methoxyethoxy (MOEOE) group at the 2'-O position and a benzoyl (Bz) protecting group on the 5-methylcytosine (5-Me-rC) amino group. The 3'-end is functionalized with a cyanoethyl (CE) group, facilitating efficient coupling reactions during solid-phase synthesis. It is utilized to introduce modified cytosine residues into nucleic acid sequences, enhancing stability and target specificity for various research applications, including RNA labeling, probing, and therapeutic development.

CAT: BRP-00621

MF: C52H64N5O11P

MF: 966.08

Purity: ≥95%

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InChIKey: FKWHQFYMJVJQSH-ACHZJAKQSA-N

IUPAC Name: (2R,3R,4R,5R)-5-(4-benzamido-5-methyl-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-(2-methoxyethoxy)ethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C52H64N5O11P/c1-36(2)57(37(3)4)69(66-29-15-28-53)68-46-45(35-65-52(40-18-13-10-14-19-40,41-20-24-43(61-7)25-21-41)42-22-26-44(62-8)27-23-42)67-50(47(46)64-33-32-63-31-30-60-6)56-34-38(5)48(55-51(56)59)54-49(58)39-16-11-9-12-17-39/h9-14,16-27,34,36-37,45-47,50H,15,29-33,35H2,1-8H3,(H,54,55,58,59)/t45-,46-,47-,50-,69?/m1/s1

Synonyms: 2'-MOEOE 5-Me-rC(Bz) amidite