Phosphoramidites - RNA / BOC Sciences

2'-OTBS U OMe-amidite

Description: 2'-OTBS U OMe-amidite is a reagent used for synthesizing modified oligonucleotides. It has uridine with a 2'-tert-butyldimethylsilyl (TBDMS) protecting group, which enhances stability during the synthesis process. This modification improves the stability and resistance of the oligonucleotides to degradation.

CAT: BRP-00828

CAS: 114207-67-9

Molecular Formula: C43H60N3O9PSi

Molecular Weight: 822.03

Purity: >95%

Appearance: White, off-white to faint yellow powder

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InChIKey: AJKMTCZXJSDRLN-CYSIDSPMSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OC)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: 1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-[[di(propan-2-yl)amino]-methoxyphosphanyl]oxyoxolan-2-yl]pyrimidine-2,4-dione

InChI: InChI=1S/C43H60N3O9PSi/c1-29(2)46(30(3)4)56(51-10)54-38-36(53-40(45-27-26-37(47)44-41(45)48)39(38)55-57(11,12)42(5,6)7)28-52-43(31-16-14-13-15-17-31,32-18-22-34(49-8)23-19-32)33-20-24-35(50-9)25-21-33/h13-27,29-30,36,38-40H,28H2,1-12H3,(H,44,47,48)/t36-,38-,39-,40-,56?/m1/s1

Synonyms: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl methyl diisopropylphosphoramidite; 5'-O-DMTr-2'-O-TBDMS-U-3'-Methoxy-phosphoramidite; 5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyl-dimethylsilyl)-uridine-3'-Methoxy-phosphoramidite; 2'-tBDSilyl Uridine methyl phosphoramidite

2'-OTBS C(Ac) OMe-amidite

Description: 2'-OTBS C(Ac) OMe-amidite is a modified phosphoramidite used in oligonucleotide synthesis to introduce 2'-OTBS modifications into RNA sequences, specifically targeting cytidine (C). It enhances the stability and specificity of RNA molecules and is commonly used in applications such as RNA interference, antisense therapy, and RNA structural studies.

CAT: BRP-00830

CAS: 1360559-84-7

Molecular Formula: C45H63N4O9PSi

Molecular Weight: 863.08

Purity: >95%

Appearance: White, off-white to faint yellow powder

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InChIKey: TZHWOKHEMQAVPY-ZMHKPELYSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: O=C1N=C(C=CN1C2OC(COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)C(OP(OC)N(C(C)C)C(C)C)C2O[Si](C)(C)C(C)(C)C)NC(=O)C

IUPAC Name: (2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl methyl diisopropylphosphoramidite

InChI: InChI=1S/C45H63N4O9PSi/c1-30(2)49(31(3)4)59(54-11)57-40-38(56-42(41(40)58-60(12,13)44(6,7)8)48-28-27-39(46-32(5)50)47-43(48)51)29-55-45(33-17-15-14-16-18-33,34-19-23-36(52-9)24-20-34)35-21-25-37(53-10)26-22-35/h14-28,30-31,38,40-42H,29H2,1-13H3,(H,46,47,50,51)/t38-,40-,41-,42-,59?/m1/s1

Synonyms: Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-[methyl N,N-bis(1-methylethyl)phosphoramidite]; 5'-O-DMTr-2'-O-TBDMS-C(Ac)-3'-Methoxy-phosphoramidite; N4-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyl-dimethylsilyl)-cytidine-3'-Methoxy-phosphoramidite

2'-OTBS A(Bz) OMe-amidite

Description: 2'-OTBS A(Bz) OMe-amidite is a reagent for oligonucleotide synthesis. It features adenosine with a tert-butyldimethylsilyl (TBDMS) group at the 2'-position and a benzoyl (bz) group protecting the amino group. This compound is used to incorporate modified adenosine into synthetic oligonucleotides, enhancing their stability and resistance to degradation.

CAT: BRP-00831

CAS: 118684-39-2

Molecular Formula: C51H65N6O8PSi

Molecular Weight: 949.18

Purity: >95%

Appearance: White, off-white to faint yellow powder

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InChIKey: QECBNEWCSSUUAS-XOMUZYEBSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: O=C(NC1=NC=NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP(OC)N(C(C)C)C(C)C)C3O[Si](C)(C)C(C)(C)C)C=7C=CC=CC7

IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl methyl diisopropylphosphoramidite

InChI: InChI=1S/C51H65N6O8PSi/c1-34(2)57(35(3)4)66(61-10)64-44-42(31-62-51(37-21-17-14-18-22-37,38-23-27-40(59-8)28-24-38)39-25-29-41(60-9)30-26-39)63-49(45(44)65-67(11,12)50(5,6)7)56-33-54-43-46(52-32-53-47(43)56)55-48(58)36-19-15-13-16-20-36/h13-30,32-35,42,44-45,49H,31H2,1-12H3,(H,52,53,55,58)/t42-,44-,45-,49-,66?/m1/s1

Synonyms: 5'-O-DMTr-2'-O-TBDMS-A(Bz)-3'-Methoxy-phosphoramidite; 2'-tBDSilyl Adenosine (n-bz) methyl phosphoramidite

2'-OTBS G(iBu) OMe-amidite

Description: 2'-OTBS G(iBu) OMe-amidite is a reagent for synthesizing modified oligonucleotides. It features guanosine with a tert-butyldimethylsilyl (TBDMS) group at the 2'-position and an isobutyryl (ibu) group protecting the amino group. This modification enhances stability during synthesis and improves the resistance of oligonucleotides to degradation.

CAT: BRP-00832

CAS: 118684-41-6

Molecular Formula: C48H67N6O9PSi

Molecular Weight: 931.16

Purity: >95%

Appearance: White, off-white to faint yellow powder

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InChIKey: GQXDBSFXGQUFKG-VCGWOZLGSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: O=C1N=C(NC(=O)C(C)C)NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP(OC)N(C(C)C)C(C)C)C3O[Si](C)(C)C(C)(C)C

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl methyl diisopropylphosphoramidite

InChI: InChI=1S/C48H67N6O9PSi/c1-30(2)43(55)51-46-50-42-39(44(56)52-46)49-29-53(42)45-41(63-65(13,14)47(7,8)9)40(62-64(59-12)54(31(3)4)32(5)6)38(61-45)28-60-48(33-18-16-15-17-19-33,34-20-24-36(57-10)25-21-34)35-22-26-37(58-11)27-23-35/h15-27,29-32,38,40-41,45H,28H2,1-14H3,(H2,50,51,52,55,56)/t38-,40-,41-,45-,64?/m1/s1

Synonyms: Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-N-(2-methyl-1-oxopropyl)-, 3'-[methyl bis(1-methylethyl)phosphoramidite]; 5'-O-DMTr-2'-O-TBDMS-G(iBu)-3'-Methoxy-phosphoramidite; N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyl-dimethylsilyl)-guanosine-3'-Methoxy-phosphoramidite; 2'-tBDSilyl Guanosine (n-ibu) methyl phosphoramidite

2'-OTBS 7,9-de-8-Thio-I amidite

Description: 2'-OTBS 7,9-de-8-Thio-I amidite is a modified phosphoramidite used in oligonucleotide synthesis. This modification can confer unique properties to oligonucleotides and is utilized in various applications in molecular biology and nucleic acid chemistry research.

CAT: BRP-00833

Molecular Formula: C47H61N4O8PSSi

Molecular Weight: 901.15

Purity: >98%

Appearance: Off-white solid

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InChIKey: ICUUKKNWPLMJGN-SRYSXPHVSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(4-oxo-3,4-dihydrothieno[3,4-d]pyrimidin-7-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C47H61N4O8PSSi/c1-31(2)51(32(3)4)60(56-27-15-26-48)58-41-39(57-43(42(41)59-62(10,11)46(5,6)7)44-40-38(29-61-44)45(52)50-30-49-40)28-55-47(33-16-13-12-14-17-33,34-18-22-36(53-8)23-19-34)35-20-24-37(54-9)25-21-35/h12-14,16-25,29-32,39,41-43H,15,27-28H2,1-11H3,(H,49,50,52)/t39-,41-,42-,43-,60?/m1/s1

2'-O-NMA MeC(iBu) amidite

Description: 2'-O-NMA MeC(iBu) amidite is a modified phosphoramidite used in oligonucleotide synthesis. The modifications enhance the stability and specificity of RNA molecules and are commonly used in various molecular biology applications.

CAT: BRP-00834

Molecular Formula: C47H61N6O10P

Molecular Weight: 901.01

Purity: >95%

Appearance: White, off-white to faint yellow powder

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InChIKey: LAHCHMSIGMYPKH-LKYMEUIMSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(4-isobutyramido-5-methyl-2-oxopyrimidin-1(2H)-yl)-4-(2-(methylamino)-2-oxoethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C47H61N6O10P/c1-30(2)44(55)50-43-33(7)27-52(46(56)51-43)45-42(59-29-40(54)49-8)41(63-64(61-26-14-25-48)53(31(3)4)32(5)6)39(62-45)28-60-47(34-15-12-11-13-16-34,35-17-21-37(57-9)22-18-35)36-19-23-38(58-10)24-20-36/h11-13,15-24,27,30-32,39,41-42,45H,14,26,28-29H2,1-10H3,(H,49,54)(H,50,51,55,56)/t39-,41-,42-,45-,64?/m1/s1

Synonyms: 5'-DMT-2'-O-NMA-5-Me-C(iBu)-3'-CE-Phosphoramidite; [4-N-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(methylamino)-2-oxoethyl]-5-methylcytidine]-3'-[(2-cyanoethyl)-N,N-diisopropyl]phosphoramidite

PMO I Monomer

Description: PMO I monomer refers to a monomeric unit used in the synthesis of Phosphorodiamidate Morpholino Oligomers (PMOs). PMOs are synthetic nucleic acid analogs that are widely used in antisense therapy and molecular biology research. They are designed to hybridize with specific RNA sequences to modulate gene expression or function. The ''I'' monomer represents one of the nucleobase modifications that can be incorporated into PMOs to confer specific properties or enhance their binding affinity and specificity.

CAT: BRP-00835

CAS: 1044241-76-0

Molecular Formula: C31H32ClN6O4P

Molecular Weight: 619.06

Purity: >98%

Appearance: Off-white solid

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Density: 1.38±0.1 g/cm3

Boiling Point: 761.0±70.0 °C at 760 mmHg

InChIKey: YCFWIWLBQZCQQO-RXDNIKEDSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: O=C1N=CNC2=C1N=CN2C3OC(COP(=O)(Cl)N(C)C)CN(C3)C(C=4C=CC=CC4)(C=5C=CC=CC5)C=6C=CC=CC6

IUPAC Name: ((2S,6R)-6-(6-oxo-1,6-dihydro-9H-purin-9-yl)-4-tritylmorpholin-2-yl)methyl dimethylphosphoramidochloridate

InChI: InChI=1S/C31H32ClN6O4P/c1-36(2)43(32,40)41-20-26-18-37(19-27(42-26)38-22-35-28-29(38)33-21-34-30(28)39)31(23-12-6-3-7-13-23,24-14-8-4-9-15-24)25-16-10-5-11-17-25/h3-17,21-22,26-27H,18-20H2,1-2H3,(H,33,34,39)/t26-,27+,43?/m0/s1

Synonyms: Phosphoramidochloridic acid, N,N-dimethyl-, [(2S,6R)-6-(1,6-dihydro-6-oxo-9H-purin-9-yl)-4-(triphenylmethyl)-2-morpholinyl]methyl ester; [(2S,6R)-6-(1,6-Dihydro-6-oxo-9H-purin-9-yl)-4-(triphenylmethyl)-2-morpholinyl]methyl N,N-dimethylphosphoramidochloridate

PMO I(NPE) Monomer

Description: PMO I(NPE) monomer refers to a monomeric unit used in the synthesis of Phosphorodiamidate Morpholino Oligomers (PMOs). PMOs are synthetic nucleic acid analogs used in antisense therapy and molecular biology research. The ''I(NPE)'' modification provides unique properties to the PMO, such as enhanced binding affinity or stability, and it can be used to target specific RNA sequences for therapeutic or research purposes.

CAT: BRP-00836

Molecular Formula: C39H39ClN7O6P

Molecular Weight: 768.21

Purity: >98%

Appearance: Yellow solid

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InChIKey: FQWVICSCUXDSJM-SSGMMMFMSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: ((2S,6R)-6-(6-(4-nitrophenethoxy)-9H-purin-9-yl)-4-tritylmorpholin-2-yl)methyl dimethylphosphoramidochloridate

InChI: InChI=1S/C39H39ClN7O6P/c1-44(2)54(40,50)52-26-34-24-45(39(30-12-6-3-7-13-30,31-14-8-4-9-15-31)32-16-10-5-11-17-32)25-35(53-34)46-28-43-36-37(46)41-27-42-38(36)51-23-22-29-18-20-33(21-19-29)47(48)49/h3-21,27-28,34-35H,22-26H2,1-2H3/t34-,35+,54?/m0/s1

(R)-SNA MeC(Bz) amidite

Description: (R)-SNA MeC(Bz) amidite is a modified phosphoramidite used in oligonucleotide synthesis. It is used to introduce SNA backbone modifications and benzoyl-protected cytidine residues during solid-phase oligonucleotide synthesis. SNA modifications can enhance the stability and binding affinity of oligonucleotides, and benzoyl protection allows selective deprotection under mild conditions.

CAT: BRP-00837

Molecular Formula: C47H55N6O8P

Molecular Weight: 862.97

Purity: >95%

Appearance: Off-white solid

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InChIKey: INDCRCPSOKWLRY-CEEWGNETSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (R)-2-(2-(4-benzamido-5-methyl-2-oxopyrimidin-1(2H)-yl)acetamido)-3-(bis(4-methoxyphenyl)(phenyl)methoxy)propyl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C47H55N6O8P/c1-33(2)53(34(3)4)62(60-28-14-27-48)61-32-40(49-43(54)30-52-29-35(5)44(51-46(52)56)50-45(55)36-15-10-8-11-16-36)31-59-47(37-17-12-9-13-18-37,38-19-23-41(57-6)24-20-38)39-21-25-42(58-7)26-22-39/h8-13,15-26,29,33-34,40H,14,28,30-32H2,1-7H3,(H,49,54)(H,50,51,55,56)/t40-,62?/m1/s1

Synonyms: (R)-SNA C(Bz) amidite; (R)-SNA 5-Me-C(Bz) amidite

(R)-SNA G(iBu) amidite

Description: (R)-SNA G(iBu) amidite is a modified phosphoramidite used in oligonucleotide synthesis. It is used to introduce SNA backbone modifications and isobutyl-protected guanosine residues during solid-phase oligonucleotide synthesis. SNA modifications can enhance the stability and binding affinity of oligonucleotides, and isobutyl protection allows selective deprotection under mild conditions.

CAT: BRP-00838

Molecular Formula: C44H55N8O8P

Molecular Weight: 854.95

Purity: >95%

Appearance: Off-white solid

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InChIKey: GIZOJVPZHAXHBF-KGRUAYADSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (R)-3-(bis(4-methoxyphenyl)(phenyl)methoxy)-2-(2-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)acetamido)propyl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C44H55N8O8P/c1-29(2)41(54)49-43-48-40-39(42(55)50-43)46-28-51(40)25-38(53)47-35(27-60-61(59-24-12-23-45)52(30(3)4)31(5)6)26-58-44(32-13-10-9-11-14-32,33-15-19-36(56-7)20-16-33)34-17-21-37(57-8)22-18-34/h9-11,13-22,28-31,35H,12,24-27H2,1-8H3,(H,47,53)(H2,48,49,50,54,55)/t35-,61?/m1/s1

Related CAS: 1280548-97-1 (S-isomer)

LNA I amidite

Description: LNA I amidite is a phosphoramidite used in oligonucleotide synthesis to introduce LNA (Locked Nucleic Acid) modifications containing an inosine (I) nucleobase. LNA modifications enhance the stability and binding affinity of oligonucleotides to their complementary RNA or DNA strands. LNA I amidite allows for the synthesis of oligonucleotides containing inosine-modified LNA residues, which can be useful in various molecular biology applications, including antisense therapy, RNA structural studies, and gene expression modulation.

CAT: BRP-00839

Molecular Formula: C41H47N6O8P

Molecular Weight: 782.84

Purity: >98%

Appearance: Off-white solid

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InChIKey: JVTYXZHEHLVHJW-NKXPIFMZSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C2C(OC1(CO2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)N6C=NC7=C6N=CNC7=O

IUPAC Name: 3-[[(1R,3R,4R,7S)-1-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-(6-oxo-1H-purin-9-yl)-2,5-dioxabicyclo[2.2.1]heptan-7-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C41H47N6O8P/c1-27(2)47(28(3)4)56(53-22-10-21-42)55-36-35-39(46-26-45-34-37(46)43-25-44-38(34)48)54-40(36,23-51-35)24-52-41(29-11-8-7-9-12-29,30-13-17-32(49-5)18-14-30)31-15-19-33(50-6)20-16-31/h7-9,11-20,25-28,35-36,39H,10,22-24H2,1-6H3,(H,43,44,48)/t35-,36+,39-,40-,56?/m1/s1

Synonyms: (1R,3R,4R,7S)-1-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-(6-oxo-1,6-dihydro-9H-purin-9-yl)-2,5-dioxabicyclo[2.2.1]heptan-7-yl (2-cyanoethyl) diisopropylphosphoramidite

2'-MOE MeC(Ac) OMe-amidite

Description: 2'-MOE MeC(Ac) OMe-amidite is a modified phosphoramidite used in oligonucleotide synthesis to introduce 2'-methoxyethyl (2'-MOE) modifications into cytidine (C) residues. 2'-MOE MeC(Ac) OMe-amidite is crucial for the controlled synthesis of modified oligonucleotides, which find applications in molecular biology research, diagnostics, and therapeutics.

CAT: BRP-00840

Molecular Formula: C43H57N4O10P

Molecular Weight: 820.92

Purity: >95%

Appearance: Off-white solid

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InChIKey: FKPROVDGFNABNE-KZQAAKLLSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4R,5R)-5-(4-acetamido-5-methyl-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl methyl diisopropylphosphoramidite

InChI: InChI=1S/C43H57N4O10P/c1-28(2)47(29(3)4)58(53-10)57-38-37(56-41(39(38)54-25-24-50-7)46-26-30(5)40(44-31(6)48)45-42(46)49)27-55-43(32-14-12-11-13-15-32,33-16-20-35(51-8)21-17-33)34-18-22-36(52-9)23-19-34/h11-23,26,28-29,37-39,41H,24-25,27H2,1-10H3,(H,44,45,48,49)/t37-,38-,39-,41-,58?/m1/s1

1-DMTr-2-propanediyl amidite

Description: 1-DMTr-2-propanediyl amidite is a phosphoramidite used in oligonucleotide synthesis. It serves as a spacer moiety during solid-phase oligonucleotide synthesis, allowing for the attachment of nucleotide building blocks to a growing oligonucleotide chain. 1-DMTr-2-propanediyl amidite plays a crucial role in the efficient and controlled synthesis of oligonucleotides for various applications in molecular biology and biotechnology.

CAT: BRP-00841

Molecular Formula: C33H43N2O5P

Molecular Weight: 578.69

Purity: >95%

Appearance: Light-yellow oily matter

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InChIKey: XCLJWHBPKOARSH-UHFFFAOYSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC(C)COC(C1=CC=CC=C1)(C2=CC=C(C=C2)OC)C3=CC=C(C=C3)OC

IUPAC Name: 3-[1-[bis(4-methoxyphenyl)-phenylmethoxy]propan-2-yloxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C33H43N2O5P/c1-25(2)35(26(3)4)41(39-23-11-22-34)40-27(5)24-38-33(28-12-9-8-10-13-28,29-14-18-31(36-6)19-15-29)30-16-20-32(37-7)21-17-30/h8-10,12-21,25-27H,11,23-24H2,1-7H3

Synonyms: 1-(bis(4-methoxyphenyl)(phenyl)methoxy)propan-2-yl (2-cyanoethyl) diisopropylphosphoramidite

LNA MeC(pac) amidite

Description: LNA MeC(pac) amidite is a modified phosphoramidite used in oligonucleotide synthesis to introduce Locked Nucleic Acid (LNA) modifications containing a methylated cytidine (MeC) base with a phenoxyacetyl (pac) protecting group. LNA MeC(pac) amidite allows for the synthesis of oligonucleotides containing LNA modifications with methylated cytidine residues, which can be useful in various molecular biology applications, including gene expression modulation and RNA targeting.

CAT: BRP-00842

Molecular Formula: C49H56N5O10P

Molecular Weight: 905.99

Purity: >95%

Appearance: Off-white solid

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InChIKey: PRARYIAJOKFQRQ-MJKSTTCNSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (1R,3R,4R,7S)-1-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-(5-methyl-2-oxo-4-(2-phenoxyacetamido)pyrimidin-1(2H)-yl)-2,5-dioxabicyclo[2.2.1]heptan-7-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C49H56N5O10P/c1-33(2)54(34(3)4)65(62-28-14-27-50)64-44-43-46(53-29-35(5)45(52-47(53)56)51-42(55)30-59-41-17-12-9-13-18-41)63-48(44,31-60-43)32-61-49(36-15-10-8-11-16-36,37-19-23-39(57-6)24-20-37)38-21-25-40(58-7)26-22-38/h8-13,15-26,29,33-34,43-44,46H,14,28,30-32H2,1-7H3,(H,51,52,55,56)/t43-,44+,46-,48-,65?/m1/s1

Synonyms: LNA-5-Me-C(pac) CE-Phosphoramidite; DMTr-LNA-5MeC(pac)-3-CED-phosphoramidite

MMTr PEG3 amidite

Description: MMTr PEG3 amidite is a modified phosphoramidite used in oligonucleotide synthesis. It serves as a linker during solid-phase oligonucleotide synthesis, allowing for the attachment of nucleotide building blocks to a growing oligonucleotide chain with the flexibility provided by the PEG3 linker. MMTr PEG3 amidite plays a crucial role in the efficient and controlled synthesis of oligonucleotides for various applications in molecular biology and biotechnology, particularly when flexibility or spacing is desired.

CAT: BRP-00843

Molecular Formula: C35H47N2O6P

Molecular Weight: 622.74

Purity: >95%

Appearance: Colourless oily matter

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InChIKey: FUFCVFZHFJGQTH-UHFFFAOYSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: N#CCCOP(OCCOCCOCCOC(C(C=C1)=CC=C1OC)(C2=CC=CC=C2)C3=CC=CC=C3)N(C(C)C)C(C)C

IUPAC Name: 2-cyanoethyl (2-(2-(2-((4-methoxyphenyl)diphenylmethoxy)ethoxy)ethoxy)ethyl) diisopropylphosphoramidite

InChI: InChI=1S/C35H47N2O6P/c1-29(2)37(30(3)4)44(42-22-12-21-36)43-28-26-40-24-23-39-25-27-41-35(31-13-8-6-9-14-31,32-15-10-7-11-16-32)33-17-19-34(38-5)20-18-33/h6-11,13-20,29-30H,12,22-28H2,1-5H3

LNA MeC(dmf) amidite

Description: LNA MeC(dmf) amidite is a modified phosphoramidite used in oligonucleotide synthesis to introduce Locked Nucleic Acid (LNA) modifications containing a methylated cytidine (MeC) base with a dimethylformamidine (dmf) protecting group. LNA MeC(dmf) amidite allows for the synthesis of oligonucleotides containing LNA modifications with methylated cytidine residues, which can be useful in various molecular biology applications, including gene expression modulation and RNA targeting.

CAT: BRP-00844

Molecular Formula: C44H55N6O8P

Molecular Weight: 826.93

Purity: >98%

Appearance: Off-white solid

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InChIKey: ALMLYLOSIBVJJH-JHFWARBRSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (1R,3R,4R,7S)-1-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-(4-(((dimethylamino)methylene)amino)-5-methyl-2-oxopyrimidin-1(2H)-yl)-2,5-dioxabicyclo[2.2.1]heptan-7-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C44H55N6O8P/c1-30(2)50(31(3)4)59(56-25-13-24-45)58-39-38-41(49-26-32(5)40(47-42(49)51)46-29-48(6)7)57-43(39,27-54-38)28-55-44(33-14-11-10-12-15-33,34-16-20-36(52-8)21-17-34)35-18-22-37(53-9)23-19-35/h10-12,14-23,26,29-31,38-39,41H,13,25,27-28H2,1-9H3/t38-,39+,41-,43-,59?/m1/s1

Synonyms: LNA-5-Me-C(dmf) CE-Phosphoramidite; DMTr-LNA-5MeC(dmf)-3-CED-phosphoramidite

LNA A(dmf) amidite

Description: LNA A(dmf) amidite is a modified phosphoramidite used in oligonucleotide synthesis to introduce Locked Nucleic Acid (LNA) modifications containing a dimethylformamidine (dmf) protecting group on adenine (A) nucleobase. LNA A(dmf) amidite allows for the synthesis of oligonucleotides containing LNA modifications with adenine residues protected by dimethylformamidine, which can be useful in various molecular biology applications, including gene expression modulation and RNA targeting.

CAT: BRP-00845

Molecular Formula: C44H53N8O7P

Molecular Weight: 836.93

Purity: >98%

Appearance: Off-white solid

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InChIKey: VCQRTYMXOYNMDL-IPPGHXGVSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (1R,3R,4R,7S)-1-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-(6-(((dimethylamino)methylene)amino)-9H-purin-9-yl)-2,5-dioxabicyclo[2.2.1]heptan-7-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C44H53N8O7P/c1-30(2)52(31(3)4)60(57-24-12-23-45)59-39-38-42(51-29-48-37-40(49-28-50(5)6)46-27-47-41(37)51)58-43(39,25-55-38)26-56-44(32-13-10-9-11-14-32,33-15-19-35(53-7)20-16-33)34-17-21-36(54-8)22-18-34/h9-11,13-22,27-31,38-39,42H,12,24-26H2,1-8H3/t38-,39+,42-,43-,60?/m1/s1

Synonyms: LNA A(dmf) CE-Phosphoramidite; DMTr-LNA-A(dmf)-3-CED-phosphoramidite

MMTr C3 amine amidite

Description: MMTr C3 amine amidite is a modified phosphoramidite used in oligonucleotide synthesis. It serves as a linker during solid-phase oligonucleotide synthesis, allowing for the attachment of nucleotide building blocks to a growing oligonucleotide chain. MMTr C3 amine amidite plays a crucial role in the efficient and controlled synthesis of oligonucleotides for various applications in molecular biology and biotechnology.

CAT: BRP-00846

CAS: 119462-97-4

Molecular Formula: C32H42N3O3P

Molecular Weight: 547.68

Purity: >95%

Appearance: Light-yellow oily matter

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InChIKey: ZDCIPDOLNLJZRB-UHFFFAOYSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCCNC(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=C(C=C3)OC)OCCC#N

IUPAC Name: 3-[[di(propan-2-yl)amino]-[3-[[(4-methoxyphenyl)-diphenylmethyl]amino]propoxy]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C32H42N3O3P/c1-26(2)35(27(3)4)39(37-24-12-22-33)38-25-13-23-34-32(28-14-8-6-9-15-28,29-16-10-7-11-17-29)30-18-20-31(36-5)21-19-30/h6-11,14-21,26-27,34H,12-13,23-25H2,1-5H3

Synonyms: 2-Cyanoethyl 3-[[(4-methoxyphenyl)diphenylmethyl]amino]propyl N,N-bis(1-methylethyl)phosphoramidite; 2-cyanoethyl (3-(((4-methoxyphenyl)diphenylmethyl)amino)propyl) diisopropylphosphoramidite; MMTr C3 linker Phosphoramidite; Monomethoxytrityl-propylamine-linker Phosphoramidite

(S)-BuNA U amidite

Description: (S)-BuNA U amidite is a modified phosphoramidite used in oligonucleotide synthesis. It is used in the synthesis of modified oligonucleotides for various applications in molecular biology, diagnostics, and therapeutics.

CAT: BRP-00847

CAS: 1452390-83-8

Molecular Formula: C38H47N4O7P

Molecular Weight: 702.79

Purity: >95%

Appearance: Off-white solid

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InChIKey: GMUTXDAJRYBBQH-NMIPJSAASA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: N#CCCOP(OC(CN1C=CC(=O)NC1=O)CCOC(C=2C=CC=CC2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)N(C(C)C)C(C)C

IUPAC Name: (S)-4-(bis(4-methoxyphenyl)(phenyl)methoxy)-1-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butan-2-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C38H47N4O7P/c1-28(2)42(29(3)4)50(48-25-10-23-39)49-35(27-41-24-21-36(43)40-37(41)44)22-26-47-38(30-11-8-7-9-12-30,31-13-17-33(45-5)18-14-31)32-15-19-34(46-6)20-16-32/h7-9,11-21,24,28-29,35H,10,22,25-27H2,1-6H3,(H,40,43,44)/t35-,50?/m0/s1

Synonyms: Phosphoramidous acid, N,N-bis(1-methylethyl)-, (1S)-3-[bis(4-methoxyphenyl)phenylmethoxy]-1-[(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)methyl]propyl 2-cyanoethyl ester; (1S)-3-[Bis(4-methoxyphenyl)phenylmethoxy]-1-[(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)methyl]propyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite

(S)-BuNA C(Bz) amidite

Description: (S)-BuNA C(Bz) amidite is a modified phosphoramidite used in oligonucleotide synthesis. It is used in the synthesis of modified oligonucleotides for various applications in molecular biology, diagnostics, and therapeutics.

CAT: BRP-00848

CAS: 1452390-96-3

Molecular Formula: C45H52N5O7P

Molecular Weight: 805.91

Purity: >95%

Appearance: Off-white solid

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InChIKey: OZJXSCDXPZBOPH-ONFVIWAESA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC(CCOC(C1=CC=CC=C1)(C2=CC=C(C=C2)OC)C3=CC=C(C=C3)OC)CN4C=CC(=NC4=O)NC(=O)C5=CC=CC=C5

IUPAC Name: N-[1-[(2S)-4-[bis(4-methoxyphenyl)-phenylmethoxy]-2-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxybutyl]-2-oxopyrimidin-4-yl]benzamide

InChI: InChI=1S/C45H52N5O7P/c1-33(2)50(34(3)4)58(56-30-13-28-46)57-41(32-49-29-26-42(48-44(49)52)47-43(51)35-14-9-7-10-15-35)27-31-55-45(36-16-11-8-12-17-36,37-18-22-39(53-5)23-19-37)38-20-24-40(54-6)25-21-38/h7-12,14-26,29,33-34,41H,13,27,30-32H2,1-6H3,(H,47,48,51,52)/t41-,58?/m0/s1

Synonyms: (S)-1-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-4-(bis(4-methoxyphenyl)(phenyl)methoxy)butan-2-yl (2-cyanoethyl) diisopropylphosphoramidite