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Phosphoramidites

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2'-Modified Phosphoramidites
(466/466) 2'-Phosphoramidites
(21/21) 3'-Modified Phosphoramidites
(186/186) 5'-Modified Phosphoramidites
(21/21) Arabino Phosphoramidites
(19/19) Base Protected Phosphoramidites (365/365) Dye Phosphoramidites
(53/53) Label Phosphoramidites
(82/82) Linker Phosphoramidites
(72/72) Other Phosphoramidites
(92/92) PMO Phosphoramidates and Derivatives (33/33) PseudoUridine Phosphoramidite
(12/12) Reverse Phosphoramidites
(15/15) Spacer Phosphoramidites
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2'-OTBS C(Ac) OMe-amidite

Description: 2'-OTBS C(Ac) OMe-amidite is a modified phosphoramidite used in oligonucleotide synthesis to introduce 2'-OTBS modifications into RNA sequences, specifically targeting cytidine (C). It enhances the stability and specificity of RNA molecules and is commonly used in applications such as RNA interference, antisense therapy, and RNA structural studies.
CAT: BRP-00830
CAS: 1360559-84-7
MF: C45H63N4O9PSi
MF: 863.08
Purity: >95%
Appearance: White, off-white to faint yellow powder
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Storage: Store at -20 °C
InChIKey: TZHWOKHEMQAVPY-ZMHKPELYSA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: O=C1N=C(C=CN1C2OC(COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)C(OP(OC)N(C(C)C)C(C)C)C2O[Si](C)(C)C(C)(C)C)NC(=O)C
IUPAC Name: (2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl methyl diisopropylphosphoramidite
InChI: InChI=1S/C45H63N4O9PSi/c1-30(2)49(31(3)4)59(54-11)57-40-38(56-42(41(40)58-60(12,13)44(6,7)8)48-28-27-39(46-32(5)50)47-43(48)51)29-55-45(33-17-15-14-16-18-33,34-19-23-36(52-9)24-20-34)35-21-25-37(53-10)26-22-35/h14-28,30-31,38,40-42H,29H2,1-13H3,(H,46,47,50,51)/t38-,40-,41-,42-,59?/m1/s1
Synonyms: Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-[methyl N,N-bis(1-methylethyl)phosphoramidite]; 5'-O-DMTr-2'-O-TBDMS-C(Ac)-3'-Methoxy-phosphoramidite; N4-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyl-dimethylsilyl)-cytidine-3'-Methoxy-phosphoramidite

2'-OTBS A(Bz) OMe-amidite

Description: 2'-OTBS A(Bz) OMe-amidite is a reagent for oligonucleotide synthesis. It features adenosine with a tert-butyldimethylsilyl (TBDMS) group at the 2'-position and a benzoyl (bz) group protecting the amino group. This compound is used to incorporate modified adenosine into synthetic oligonucleotides, enhancing their stability and resistance to degradation.
CAT: BRP-00831
CAS: 118684-39-2
MF: C51H65N6O8PSi
MF: 949.18
Purity: >95%
Appearance: White, off-white to faint yellow powder
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Storage: Store at -20 °C
InChIKey: QECBNEWCSSUUAS-XOMUZYEBSA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: O=C(NC1=NC=NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP(OC)N(C(C)C)C(C)C)C3O[Si](C)(C)C(C)(C)C)C=7C=CC=CC7
IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl methyl diisopropylphosphoramidite
InChI: InChI=1S/C51H65N6O8PSi/c1-34(2)57(35(3)4)66(61-10)64-44-42(31-62-51(37-21-17-14-18-22-37,38-23-27-40(59-8)28-24-38)39-25-29-41(60-9)30-26-39)63-49(45(44)65-67(11,12)50(5,6)7)56-33-54-43-46(52-32-53-47(43)56)55-48(58)36-19-15-13-16-20-36/h13-30,32-35,42,44-45,49H,31H2,1-12H3,(H,52,53,55,58)/t42-,44-,45-,49-,66?/m1/s1
Synonyms: 5'-O-DMTr-2'-O-TBDMS-A(Bz)-3'-Methoxy-phosphoramidite; 2'-tBDSilyl Adenosine (n-bz) methyl phosphoramidite

2'-OTBS G(iBu) OMe-amidite

Description: 2'-OTBS G(iBu) OMe-amidite is a reagent for synthesizing modified oligonucleotides. It features guanosine with a tert-butyldimethylsilyl (TBDMS) group at the 2'-position and an isobutyryl (ibu) group protecting the amino group. This modification enhances stability during synthesis and improves the resistance of oligonucleotides to degradation.
CAT: BRP-00832
CAS: 118684-41-6
MF: C48H67N6O9PSi
MF: 931.16
Purity: >95%
Appearance: White, off-white to faint yellow powder
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Storage: Store at -20 °C
InChIKey: GQXDBSFXGQUFKG-VCGWOZLGSA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: O=C1N=C(NC(=O)C(C)C)NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP(OC)N(C(C)C)C(C)C)C3O[Si](C)(C)C(C)(C)C
IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl methyl diisopropylphosphoramidite
InChI: InChI=1S/C48H67N6O9PSi/c1-30(2)43(55)51-46-50-42-39(44(56)52-46)49-29-53(42)45-41(63-65(13,14)47(7,8)9)40(62-64(59-12)54(31(3)4)32(5)6)38(61-45)28-60-48(33-18-16-15-17-19-33,34-20-24-36(57-10)25-21-34)35-22-26-37(58-11)27-23-35/h15-27,29-32,38,40-41,45H,28H2,1-14H3,(H2,50,51,52,55,56)/t38-,40-,41-,45-,64?/m1/s1
Synonyms: Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-N-(2-methyl-1-oxopropyl)-, 3'-[methyl bis(1-methylethyl)phosphoramidite]; 5'-O-DMTr-2'-O-TBDMS-G(iBu)-3'-Methoxy-phosphoramidite; N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyl-dimethylsilyl)-guanosine-3'-Methoxy-phosphoramidite; 2'-tBDSilyl Guanosine (n-ibu) methyl phosphoramidite

2'-OTBS 7,9-de-8-Thio-I amidite

Description: 2'-OTBS 7,9-de-8-Thio-I amidite is a modified phosphoramidite used in oligonucleotide synthesis. This modification can confer unique properties to oligonucleotides and is utilized in various applications in molecular biology and nucleic acid chemistry research.
CAT: BRP-00833
MF: C47H61N4O8PSSi
MF: 901.15
Purity: >98%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: ICUUKKNWPLMJGN-SRYSXPHVSA-N
Solubility: Soluble in Acetonitrile, DMF
IUPAC Name: (2R,3R,4S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(4-oxo-3,4-dihydrothieno[3,4-d]pyrimidin-7-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C47H61N4O8PSSi/c1-31(2)51(32(3)4)60(56-27-15-26-48)58-41-39(57-43(42(41)59-62(10,11)46(5,6)7)44-40-38(29-61-44)45(52)50-30-49-40)28-55-47(33-16-13-12-14-17-33,34-18-22-36(53-8)23-19-34)35-20-24-37(54-9)25-21-35/h12-14,16-25,29-32,39,41-43H,15,27-28H2,1-11H3,(H,49,50,52)/t39-,41-,42-,43-,60?/m1/s1

2'-O-NMA MeC(iBu) amidite

Description: 2'-O-NMA MeC(iBu) amidite is a modified phosphoramidite used in oligonucleotide synthesis. The modifications enhance the stability and specificity of RNA molecules and are commonly used in various molecular biology applications.
CAT: BRP-00834
MF: C47H61N6O10P
MF: 901.01
Purity: >95%
Appearance: White, off-white to faint yellow powder
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Storage: Store at -20 °C
InChIKey: LAHCHMSIGMYPKH-LKYMEUIMSA-N
Solubility: Soluble in Acetonitrile, DMF
IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(4-isobutyramido-5-methyl-2-oxopyrimidin-1(2H)-yl)-4-(2-(methylamino)-2-oxoethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C47H61N6O10P/c1-30(2)44(55)50-43-33(7)27-52(46(56)51-43)45-42(59-29-40(54)49-8)41(63-64(61-26-14-25-48)53(31(3)4)32(5)6)39(62-45)28-60-47(34-15-12-11-13-16-34,35-17-21-37(57-9)22-18-35)36-19-23-38(58-10)24-20-36/h11-13,15-24,27,30-32,39,41-42,45H,14,26,28-29H2,1-10H3,(H,49,54)(H,50,51,55,56)/t39-,41-,42-,45-,64?/m1/s1
Synonyms: 5'-DMT-2'-O-NMA-5-Me-C(iBu)-3'-CE-Phosphoramidite; [4-N-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(methylamino)-2-oxoethyl]-5-methylcytidine]-3'-[(2-cyanoethyl)-N,N-diisopropyl]phosphoramidite

PMO I Monomer

Description: PMO I monomer refers to a monomeric unit used in the synthesis of Phosphorodiamidate Morpholino Oligomers (PMOs). PMOs are synthetic nucleic acid analogs that are widely used in antisense therapy and molecular biology research. They are designed to hybridize with specific RNA sequences to modulate gene expression or function. The ''I'' monomer represents one of the nucleobase modifications that can be incorporated into PMOs to confer specific properties or enhance their binding affinity and specificity.
CAT: BRP-00835
CAS: 1044241-76-0
MF: C31H32ClN6O4P
MF: 619.06
Purity: >98%
Appearance: Off-white solid
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Storage: Store at -20 °C
Density: 1.38±0.1 g/cm3
Boiling Point: 761.0±70.0 °C at 760 mmHg
InChIKey: YCFWIWLBQZCQQO-RXDNIKEDSA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: O=C1N=CNC2=C1N=CN2C3OC(COP(=O)(Cl)N(C)C)CN(C3)C(C=4C=CC=CC4)(C=5C=CC=CC5)C=6C=CC=CC6
IUPAC Name: ((2S,6R)-6-(6-oxo-1,6-dihydro-9H-purin-9-yl)-4-tritylmorpholin-2-yl)methyl dimethylphosphoramidochloridate
InChI: InChI=1S/C31H32ClN6O4P/c1-36(2)43(32,40)41-20-26-18-37(19-27(42-26)38-22-35-28-29(38)33-21-34-30(28)39)31(23-12-6-3-7-13-23,24-14-8-4-9-15-24)25-16-10-5-11-17-25/h3-17,21-22,26-27H,18-20H2,1-2H3,(H,33,34,39)/t26-,27+,43?/m0/s1
Synonyms: Phosphoramidochloridic acid, N,N-dimethyl-, [(2S,6R)-6-(1,6-dihydro-6-oxo-9H-purin-9-yl)-4-(triphenylmethyl)-2-morpholinyl]methyl ester; [(2S,6R)-6-(1,6-Dihydro-6-oxo-9H-purin-9-yl)-4-(triphenylmethyl)-2-morpholinyl]methyl N,N-dimethylphosphoramidochloridate

PMO I(NPE) Monomer

Description: PMO I(NPE) monomer refers to a monomeric unit used in the synthesis of Phosphorodiamidate Morpholino Oligomers (PMOs). PMOs are synthetic nucleic acid analogs used in antisense therapy and molecular biology research. The ''I(NPE)'' modification provides unique properties to the PMO, such as enhanced binding affinity or stability, and it can be used to target specific RNA sequences for therapeutic or research purposes.
CAT: BRP-00836
MF: C39H39ClN7O6P
MF: 768.21
Purity: >98%
Appearance: Yellow solid
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Storage: Store at -20 °C
InChIKey: FQWVICSCUXDSJM-SSGMMMFMSA-N
Solubility: Soluble in Acetonitrile, DMF
IUPAC Name: ((2S,6R)-6-(6-(4-nitrophenethoxy)-9H-purin-9-yl)-4-tritylmorpholin-2-yl)methyl dimethylphosphoramidochloridate
InChI: InChI=1S/C39H39ClN7O6P/c1-44(2)54(40,50)52-26-34-24-45(39(30-12-6-3-7-13-30,31-14-8-4-9-15-31)32-16-10-5-11-17-32)25-35(53-34)46-28-43-36-37(46)41-27-42-38(36)51-23-22-29-18-20-33(21-19-29)47(48)49/h3-21,27-28,34-35H,22-26H2,1-2H3/t34-,35+,54?/m0/s1

(R)-SNA MeC(Bz) amidite

Description: (R)-SNA MeC(Bz) amidite is a modified phosphoramidite used in oligonucleotide synthesis. It is used to introduce SNA backbone modifications and benzoyl-protected cytidine residues during solid-phase oligonucleotide synthesis. SNA modifications can enhance the stability and binding affinity of oligonucleotides, and benzoyl protection allows selective deprotection under mild conditions.
CAT: BRP-00837
MF: C47H55N6O8P
MF: 862.97
Purity: >95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: INDCRCPSOKWLRY-CEEWGNETSA-N
Solubility: Soluble in Acetonitrile, DMF
IUPAC Name: (R)-2-(2-(4-benzamido-5-methyl-2-oxopyrimidin-1(2H)-yl)acetamido)-3-(bis(4-methoxyphenyl)(phenyl)methoxy)propyl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C47H55N6O8P/c1-33(2)53(34(3)4)62(60-28-14-27-48)61-32-40(49-43(54)30-52-29-35(5)44(51-46(52)56)50-45(55)36-15-10-8-11-16-36)31-59-47(37-17-12-9-13-18-37,38-19-23-41(57-6)24-20-38)39-21-25-42(58-7)26-22-39/h8-13,15-26,29,33-34,40H,14,28,30-32H2,1-7H3,(H,49,54)(H,50,51,55,56)/t40-,62?/m1/s1
Synonyms: (R)-SNA C(Bz) amidite; (R)-SNA 5-Me-C(Bz) amidite

(R)-SNA G(iBu) amidite

Description: (R)-SNA G(iBu) amidite is a modified phosphoramidite used in oligonucleotide synthesis. It is used to introduce SNA backbone modifications and isobutyl-protected guanosine residues during solid-phase oligonucleotide synthesis. SNA modifications can enhance the stability and binding affinity of oligonucleotides, and isobutyl protection allows selective deprotection under mild conditions.
CAT: BRP-00838
MF: C44H55N8O8P
MF: 854.95
Purity: >95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: GIZOJVPZHAXHBF-KGRUAYADSA-N
Solubility: Soluble in Acetonitrile, DMF
IUPAC Name: (R)-3-(bis(4-methoxyphenyl)(phenyl)methoxy)-2-(2-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)acetamido)propyl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C44H55N8O8P/c1-29(2)41(54)49-43-48-40-39(42(55)50-43)46-28-51(40)25-38(53)47-35(27-60-61(59-24-12-23-45)52(30(3)4)31(5)6)26-58-44(32-13-10-9-11-14-32,33-15-19-36(56-7)20-16-33)34-17-21-37(57-8)22-18-34/h9-11,13-22,28-31,35H,12,24-27H2,1-8H3,(H,47,53)(H2,48,49,50,54,55)/t35-,61?/m1/s1
Related CAS: 1280548-97-1 (S-isomer)

LNA I amidite

Description: LNA I amidite is a phosphoramidite used in oligonucleotide synthesis to introduce LNA (Locked Nucleic Acid) modifications containing an inosine (I) nucleobase. LNA modifications enhance the stability and binding affinity of oligonucleotides to their complementary RNA or DNA strands. LNA I amidite allows for the synthesis of oligonucleotides containing inosine-modified LNA residues, which can be useful in various molecular biology applications, including antisense therapy, RNA structural studies, and gene expression modulation.
CAT: BRP-00839
MF: C41H47N6O8P
MF: 782.84
Purity: >98%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: JVTYXZHEHLVHJW-NKXPIFMZSA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C2C(OC1(CO2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)N6C=NC7=C6N=CNC7=O
IUPAC Name: 3-[[(1R,3R,4R,7S)-1-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-(6-oxo-1H-purin-9-yl)-2,5-dioxabicyclo[2.2.1]heptan-7-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
InChI: InChI=1S/C41H47N6O8P/c1-27(2)47(28(3)4)56(53-22-10-21-42)55-36-35-39(46-26-45-34-37(46)43-25-44-38(34)48)54-40(36,23-51-35)24-52-41(29-11-8-7-9-12-29,30-13-17-32(49-5)18-14-30)31-15-19-33(50-6)20-16-31/h7-9,11-20,25-28,35-36,39H,10,22-24H2,1-6H3,(H,43,44,48)/t35-,36+,39-,40-,56?/m1/s1
Synonyms: (1R,3R,4R,7S)-1-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-(6-oxo-1,6-dihydro-9H-purin-9-yl)-2,5-dioxabicyclo[2.2.1]heptan-7-yl (2-cyanoethyl) diisopropylphosphoramidite

2'-MOE MeC(Ac) OMe-amidite

Description: 2'-MOE MeC(Ac) OMe-amidite is a modified phosphoramidite used in oligonucleotide synthesis to introduce 2'-methoxyethyl (2'-MOE) modifications into cytidine (C) residues. 2'-MOE MeC(Ac) OMe-amidite is crucial for the controlled synthesis of modified oligonucleotides, which find applications in molecular biology research, diagnostics, and therapeutics.
CAT: BRP-00840
MF: C43H57N4O10P
MF: 820.92
Purity: >95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: FKPROVDGFNABNE-KZQAAKLLSA-N
Solubility: Soluble in Acetonitrile, DMF
IUPAC Name: (2R,3R,4R,5R)-5-(4-acetamido-5-methyl-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl methyl diisopropylphosphoramidite
InChI: InChI=1S/C43H57N4O10P/c1-28(2)47(29(3)4)58(53-10)57-38-37(56-41(39(38)54-25-24-50-7)46-26-30(5)40(44-31(6)48)45-42(46)49)27-55-43(32-14-12-11-13-15-32,33-16-20-35(51-8)21-17-33)34-18-22-36(52-9)23-19-34/h11-23,26,28-29,37-39,41H,24-25,27H2,1-10H3,(H,44,45,48,49)/t37-,38-,39-,41-,58?/m1/s1

1-DMTr-2-propanediyl amidite

Description: 1-DMTr-2-propanediyl amidite is a phosphoramidite used in oligonucleotide synthesis. It serves as a spacer moiety during solid-phase oligonucleotide synthesis, allowing for the attachment of nucleotide building blocks to a growing oligonucleotide chain. 1-DMTr-2-propanediyl amidite plays a crucial role in the efficient and controlled synthesis of oligonucleotides for various applications in molecular biology and biotechnology.
CAT: BRP-00841
MF: C33H43N2O5P
MF: 578.69
Purity: >95%
Appearance: Light-yellow oily matter
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Storage: Store at -20 °C
InChIKey: XCLJWHBPKOARSH-UHFFFAOYSA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC(C)COC(C1=CC=CC=C1)(C2=CC=C(C=C2)OC)C3=CC=C(C=C3)OC
IUPAC Name: 3-[1-[bis(4-methoxyphenyl)-phenylmethoxy]propan-2-yloxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
InChI: InChI=1S/C33H43N2O5P/c1-25(2)35(26(3)4)41(39-23-11-22-34)40-27(5)24-38-33(28-12-9-8-10-13-28,29-14-18-31(36-6)19-15-29)30-16-20-32(37-7)21-17-30/h8-10,12-21,25-27H,11,23-24H2,1-7H3
Synonyms: 1-(bis(4-methoxyphenyl)(phenyl)methoxy)propan-2-yl (2-cyanoethyl) diisopropylphosphoramidite

LNA MeC(pac) amidite

Description: LNA MeC(pac) amidite is a modified phosphoramidite used in oligonucleotide synthesis to introduce Locked Nucleic Acid (LNA) modifications containing a methylated cytidine (MeC) base with a phenoxyacetyl (pac) protecting group. LNA MeC(pac) amidite allows for the synthesis of oligonucleotides containing LNA modifications with methylated cytidine residues, which can be useful in various molecular biology applications, including gene expression modulation and RNA targeting.
CAT: BRP-00842
MF: C49H56N5O10P
MF: 905.99
Purity: >95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: PRARYIAJOKFQRQ-MJKSTTCNSA-N
Solubility: Soluble in Acetonitrile, DMF
IUPAC Name: (1R,3R,4R,7S)-1-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-(5-methyl-2-oxo-4-(2-phenoxyacetamido)pyrimidin-1(2H)-yl)-2,5-dioxabicyclo[2.2.1]heptan-7-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C49H56N5O10P/c1-33(2)54(34(3)4)65(62-28-14-27-50)64-44-43-46(53-29-35(5)45(52-47(53)56)51-42(55)30-59-41-17-12-9-13-18-41)63-48(44,31-60-43)32-61-49(36-15-10-8-11-16-36,37-19-23-39(57-6)24-20-37)38-21-25-40(58-7)26-22-38/h8-13,15-26,29,33-34,43-44,46H,14,28,30-32H2,1-7H3,(H,51,52,55,56)/t43-,44+,46-,48-,65?/m1/s1
Synonyms: LNA-5-Me-C(pac) CE-Phosphoramidite; DMTr-LNA-5MeC(pac)-3-CED-phosphoramidite

MMTr PEG3 amidite

Description: MMTr PEG3 amidite is a modified phosphoramidite used in oligonucleotide synthesis. It serves as a linker during solid-phase oligonucleotide synthesis, allowing for the attachment of nucleotide building blocks to a growing oligonucleotide chain with the flexibility provided by the PEG3 linker. MMTr PEG3 amidite plays a crucial role in the efficient and controlled synthesis of oligonucleotides for various applications in molecular biology and biotechnology, particularly when flexibility or spacing is desired.
CAT: BRP-00843
MF: C35H47N2O6P
MF: 622.74
Purity: >95%
Appearance: Colourless oily matter
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Storage: Store at -20 °C
InChIKey: FUFCVFZHFJGQTH-UHFFFAOYSA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: N#CCCOP(OCCOCCOCCOC(C(C=C1)=CC=C1OC)(C2=CC=CC=C2)C3=CC=CC=C3)N(C(C)C)C(C)C
IUPAC Name: 2-cyanoethyl (2-(2-(2-((4-methoxyphenyl)diphenylmethoxy)ethoxy)ethoxy)ethyl) diisopropylphosphoramidite
InChI: InChI=1S/C35H47N2O6P/c1-29(2)37(30(3)4)44(42-22-12-21-36)43-28-26-40-24-23-39-25-27-41-35(31-13-8-6-9-14-31,32-15-10-7-11-16-32)33-17-19-34(38-5)20-18-33/h6-11,13-20,29-30H,12,22-28H2,1-5H3

LNA MeC(dmf) amidite

Description: LNA MeC(dmf) amidite is a modified phosphoramidite used in oligonucleotide synthesis to introduce Locked Nucleic Acid (LNA) modifications containing a methylated cytidine (MeC) base with a dimethylformamidine (dmf) protecting group. LNA MeC(dmf) amidite allows for the synthesis of oligonucleotides containing LNA modifications with methylated cytidine residues, which can be useful in various molecular biology applications, including gene expression modulation and RNA targeting.
CAT: BRP-00844
MF: C44H55N6O8P
MF: 826.93
Purity: >98%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: ALMLYLOSIBVJJH-JHFWARBRSA-N
Solubility: Soluble in Acetonitrile, DMF
IUPAC Name: (1R,3R,4R,7S)-1-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-(4-(((dimethylamino)methylene)amino)-5-methyl-2-oxopyrimidin-1(2H)-yl)-2,5-dioxabicyclo[2.2.1]heptan-7-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C44H55N6O8P/c1-30(2)50(31(3)4)59(56-25-13-24-45)58-39-38-41(49-26-32(5)40(47-42(49)51)46-29-48(6)7)57-43(39,27-54-38)28-55-44(33-14-11-10-12-15-33,34-16-20-36(52-8)21-17-34)35-18-22-37(53-9)23-19-35/h10-12,14-23,26,29-31,38-39,41H,13,25,27-28H2,1-9H3/t38-,39+,41-,43-,59?/m1/s1
Synonyms: LNA-5-Me-C(dmf) CE-Phosphoramidite; DMTr-LNA-5MeC(dmf)-3-CED-phosphoramidite

LNA A(dmf) amidite

Description: LNA A(dmf) amidite is a modified phosphoramidite used in oligonucleotide synthesis to introduce Locked Nucleic Acid (LNA) modifications containing a dimethylformamidine (dmf) protecting group on adenine (A) nucleobase. LNA A(dmf) amidite allows for the synthesis of oligonucleotides containing LNA modifications with adenine residues protected by dimethylformamidine, which can be useful in various molecular biology applications, including gene expression modulation and RNA targeting.
CAT: BRP-00845
MF: C44H53N8O7P
MF: 836.93
Purity: >98%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: VCQRTYMXOYNMDL-IPPGHXGVSA-N
Solubility: Soluble in Acetonitrile, DMF
IUPAC Name: (1R,3R,4R,7S)-1-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-(6-(((dimethylamino)methylene)amino)-9H-purin-9-yl)-2,5-dioxabicyclo[2.2.1]heptan-7-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C44H53N8O7P/c1-30(2)52(31(3)4)60(57-24-12-23-45)59-39-38-42(51-29-48-37-40(49-28-50(5)6)46-27-47-41(37)51)58-43(39,25-55-38)26-56-44(32-13-10-9-11-14-32,33-15-19-35(53-7)20-16-33)34-17-21-36(54-8)22-18-34/h9-11,13-22,27-31,38-39,42H,12,24-26H2,1-8H3/t38-,39+,42-,43-,60?/m1/s1
Synonyms: LNA A(dmf) CE-Phosphoramidite; DMTr-LNA-A(dmf)-3-CED-phosphoramidite

MMTr C3 amine amidite

Description: MMTr C3 amine amidite is a modified phosphoramidite used in oligonucleotide synthesis. It serves as a linker during solid-phase oligonucleotide synthesis, allowing for the attachment of nucleotide building blocks to a growing oligonucleotide chain. MMTr C3 amine amidite plays a crucial role in the efficient and controlled synthesis of oligonucleotides for various applications in molecular biology and biotechnology.
CAT: BRP-00846
CAS: 119462-97-4
MF: C32H42N3O3P
MF: 547.68
Purity: >95%
Appearance: Light-yellow oily matter
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Storage: Store at -20 °C
InChIKey: ZDCIPDOLNLJZRB-UHFFFAOYSA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: CC(C)N(C(C)C)P(OCCCNC(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=C(C=C3)OC)OCCC#N
IUPAC Name: 3-[[di(propan-2-yl)amino]-[3-[[(4-methoxyphenyl)-diphenylmethyl]amino]propoxy]phosphanyl]oxypropanenitrile
InChI: InChI=1S/C32H42N3O3P/c1-26(2)35(27(3)4)39(37-24-12-22-33)38-25-13-23-34-32(28-14-8-6-9-15-28,29-16-10-7-11-17-29)30-18-20-31(36-5)21-19-30/h6-11,14-21,26-27,34H,12-13,23-25H2,1-5H3
Synonyms: 2-Cyanoethyl 3-[[(4-methoxyphenyl)diphenylmethyl]amino]propyl N,N-bis(1-methylethyl)phosphoramidite; 2-cyanoethyl (3-(((4-methoxyphenyl)diphenylmethyl)amino)propyl) diisopropylphosphoramidite; MMTr C3 linker Phosphoramidite; Monomethoxytrityl-propylamine-linker Phosphoramidite

(S)-BuNA U amidite

Description: (S)-BuNA U amidite is a modified phosphoramidite used in oligonucleotide synthesis. It is used in the synthesis of modified oligonucleotides for various applications in molecular biology, diagnostics, and therapeutics.
CAT: BRP-00847
CAS: 1452390-83-8
MF: C38H47N4O7P
MF: 702.79
Purity: >95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: GMUTXDAJRYBBQH-NMIPJSAASA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: N#CCCOP(OC(CN1C=CC(=O)NC1=O)CCOC(C=2C=CC=CC2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)N(C(C)C)C(C)C
IUPAC Name: (S)-4-(bis(4-methoxyphenyl)(phenyl)methoxy)-1-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butan-2-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C38H47N4O7P/c1-28(2)42(29(3)4)50(48-25-10-23-39)49-35(27-41-24-21-36(43)40-37(41)44)22-26-47-38(30-11-8-7-9-12-30,31-13-17-33(45-5)18-14-31)32-15-19-34(46-6)20-16-32/h7-9,11-21,24,28-29,35H,10,22,25-27H2,1-6H3,(H,40,43,44)/t35-,50?/m0/s1
Synonyms: Phosphoramidous acid, N,N-bis(1-methylethyl)-, (1S)-3-[bis(4-methoxyphenyl)phenylmethoxy]-1-[(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)methyl]propyl 2-cyanoethyl ester; (1S)-3-[Bis(4-methoxyphenyl)phenylmethoxy]-1-[(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)methyl]propyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite

(S)-BuNA C(Bz) amidite

Description: (S)-BuNA C(Bz) amidite is a modified phosphoramidite used in oligonucleotide synthesis. It is used in the synthesis of modified oligonucleotides for various applications in molecular biology, diagnostics, and therapeutics.
CAT: BRP-00848
CAS: 1452390-96-3
MF: C45H52N5O7P
MF: 805.91
Purity: >95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: OZJXSCDXPZBOPH-ONFVIWAESA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC(CCOC(C1=CC=CC=C1)(C2=CC=C(C=C2)OC)C3=CC=C(C=C3)OC)CN4C=CC(=NC4=O)NC(=O)C5=CC=CC=C5
IUPAC Name: N-[1-[(2S)-4-[bis(4-methoxyphenyl)-phenylmethoxy]-2-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxybutyl]-2-oxopyrimidin-4-yl]benzamide
InChI: InChI=1S/C45H52N5O7P/c1-33(2)50(34(3)4)58(56-30-13-28-46)57-41(32-49-29-26-42(48-44(49)52)47-43(51)35-14-9-7-10-15-35)27-31-55-45(36-16-11-8-12-17-36,37-18-22-39(53-5)23-19-37)38-20-24-40(54-6)25-21-38/h7-12,14-26,29,33-34,41H,13,27,30-32H2,1-6H3,(H,47,48,51,52)/t41-,58?/m0/s1
Synonyms: (S)-1-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-4-(bis(4-methoxyphenyl)(phenyl)methoxy)butan-2-yl (2-cyanoethyl) diisopropylphosphoramidite

(S)-BuNA A(Bz) amidite

Description: (S)-BuNA A(Bz) amidite is a modified phosphoramidite used in oligonucleotide synthesis. It is used in the synthesis of modified oligonucleotides for various applications in molecular biology, diagnostics, and therapeutics.
CAT: BRP-00849
CAS: 1452390-99-6
MF: C46H52N7O6P
MF: 829.94
Purity: >95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: QOLFEXISLSPHKS-CTHPAJCMSA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC(CCOC(C1=CC=CC=C1)(C2=CC=C(C=C2)OC)C3=CC=C(C=C3)OC)CN4C=NC5=C(N=CN=C54)NC(=O)C6=CC=CC=C6
IUPAC Name: N-[9-[(2S)-4-[bis(4-methoxyphenyl)-phenylmethoxy]-2-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxybutyl]purin-6-yl]benzamide
InChI: InChI=1S/C46H52N7O6P/c1-33(2)53(34(3)4)60(58-28-13-27-47)59-41(30-52-32-50-42-43(48-31-49-44(42)52)51-45(54)35-14-9-7-10-15-35)26-29-57-46(36-16-11-8-12-17-36,37-18-22-39(55-5)23-19-37)38-20-24-40(56-6)25-21-38/h7-12,14-25,31-34,41H,13,26,28-30H2,1-6H3,(H,48,49,51,54)/t41-,60?/m0/s1
Synonyms: (S)-1-(6-benzamido-9H-purin-9-yl)-4-(bis(4-methoxyphenyl)(phenyl)methoxy)butan-2-yl (2-cyanoethyl) diisopropylphosphoramidite
* Only for research. Not suitable for any diagnostic or therapeutic use.

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