Phosphoramidites - RNA / BOC Sciences

2'-OAlly A(Bz) amidite

Description: 2'-OAlly A(Bz) amidite is a modified phosphoramidite used in oligonucleotide synthesis. It serves as a building block during solid-phase oligonucleotide synthesis, enabling the incorporation of adenine residues modified with 2'-O-allyl and protected with benzoyl (Bz) into the oligonucleotide sequence. This compound is essential for synthesizing oligonucleotides with specific modifications, which can be utilized in various applications such as molecular biology research, diagnostics, and therapeutics.

CAT: BRP-00870

CAS: 136834-09-8

MF: C50H56N7O8P

MF: 914.01

Purity: >95%

Appearance: Off-white solid

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InChIKey: PZHYXONYDRPFHJ-XOMUZYEBSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OCC=C)N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-prop-2-enoxyoxolan-2-yl]purin-6-yl]benzamide

InChI: InChI=1S/C50H56N7O8P/c1-8-29-61-45-44(65-66(63-30-15-28-51)57(34(2)3)35(4)5)42(64-49(45)56-33-54-43-46(52-32-53-47(43)56)55-48(58)36-16-11-9-12-17-36)31-62-50(37-18-13-10-14-19-37,38-20-24-40(59-6)25-21-38)39-22-26-41(60-7)27-23-39/h8-14,16-27,32-35,42,44-45,49H,1,15,29-31H2,2-7H3,(H,52,53,55,58)/t42-,44-,45-,49-,66?/m1/s1

Synonyms: (2R,3R,4R,5R)-4-(Allyloxy)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-2-propenyl-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

2'-OAlly G(iBu) amidite

Description: 2'-OAlly G(iBu) amidite is a modified phosphoramidite used in oligonucleotide synthesis. It serves as a building block during solid-phase oligonucleotide synthesis, allowing the incorporation of guanine residues modified with 2'-O-allyl and protected with isobutyl (iBu) into the oligonucleotide sequence. This compound is crucial for synthesizing oligonucleotides with specific modifications, which can be utilized in various applications such as molecular biology research, diagnostics, and therapeutics.

CAT: BRP-00871

CAS: 163070-99-3

MF: C47H58N7O9P

MF: 896.00

Purity: >95%

Appearance: Off-white solid

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InChIKey: WZIZCXQOBBGIEA-VCGWOZLGSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C(=O)N=C(NC(=O)C(C)C)NC32)C1OCC=C)COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-4-(allyloxy)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C47H58N7O9P/c1-10-26-59-41-40(63-64(61-27-14-25-48)54(31(4)5)32(6)7)38(62-45(41)53-29-49-39-42(53)50-46(52-44(39)56)51-43(55)30(2)3)28-60-47(33-15-12-11-13-16-33,34-17-21-36(57-8)22-18-34)35-19-23-37(58-9)24-20-35/h10-13,15-24,29-32,38,40-41,45H,1,14,26-28H2,2-9H3,(H2,50,51,52,55,56)/t38-,40-,41-,45-,64?/m1/s1

Synonyms: Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N-(2-methyl-1-oxopropyl)-2'-O-2-propenyl-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

2'-OAlly U amidite

Description: 2'-OAlly U amidite is a modified phosphoramidite used in oligonucleotide synthesis. It serves as a building block during solid-phase oligonucleotide synthesis, enabling the incorporation of uracil residues modified with 2'-O-allyl into the oligonucleotide sequence. This compound is essential for synthesizing oligonucleotides with specific modifications, which can be utilized in various applications such as molecular biology research, diagnostics, and therapeutics.

CAT: BRP-00872

CAS: 171486-64-9

MF: C42H51N4O9P

MF: 786.86

Purity: >95%

Appearance: Off-white solid

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InChIKey: PRCRTSIDLZWSDO-CYSIDSPMSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OCC=C)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(2,4-dioxopyrimidin-1-yl)-4-prop-2-enoxyoxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C42H51N4O9P/c1-8-26-51-39-38(55-56(53-27-12-24-43)46(29(2)3)30(4)5)36(54-40(39)45-25-23-37(47)44-41(45)48)28-52-42(31-13-10-9-11-14-31,32-15-19-34(49-6)20-16-32)33-17-21-35(50-7)22-18-33/h8-11,13-23,25,29-30,36,38-40H,1,12,26-28H2,2-7H3,(H,44,47,48)/t36-,38-,39-,40-,56?/m1/s1

Synonyms: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-2-propenyl-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; (2R,3R,4R,5R)-4-(allyloxy)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; 5-O-(4,4'-dimethoxytrityl)-2-O-allyl-3-O-(diisopropylamino-2-cyanoethoxyphosphanyl)-1-deoxy-1-uracil-1-yl-beta-D-ribo-pentofuranose

2'-OTBS MeC(pac) amidite

Description: 2'-OTBS MeC(pac) amidite is a modified phosphoramidite used in oligonucleotide synthesis. It serves as a building block during solid-phase oligonucleotide synthesis, enabling the incorporation of cytidine residues modified with 2'-O-tert-butyldimethylsilyl (2'-OTBS) and protected with phenoxyacetyl (pac) into the oligonucleotide sequence. This compound is crucial for synthesizing oligonucleotides with specific modifications, which can be utilized in various applications such as molecular biology research, diagnostics, and therapeutics.

CAT: BRP-00873

MF: C54H70N5O10PSi

MF: 1008.24

Purity: >95%

Appearance: Off-white solid

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InChIKey: HKKHIMPFWSYKJT-XCUKYXTNSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(5-methyl-2-oxo-4-(2-phenoxyacetamido)pyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C54H70N5O10PSi/c1-37(2)59(38(3)4)70(66-33-19-32-55)68-48-46(35-65-54(40-20-15-13-16-21-40,41-24-28-43(62-9)29-25-41)42-26-30-44(63-10)31-27-42)67-51(49(48)69-71(11,12)53(6,7)8)58-34-39(5)50(57-52(58)61)56-47(60)36-64-45-22-17-14-18-23-45/h13-18,20-31,34,37-38,46,48-49,51H,19,33,35-36H2,1-12H3,(H,56,57,60,61)/t46-,48-,49-,51-,70?/m1/s1

Synonyms: 5'-O-DMT-2'-O-TBDMS-5-Me-C(pac) 3'-CE Phosphoramidite

2'-OPivOM U amidite

Description: 2'-O-PivOM U amidite is a specialized nucleotide for oligonucleotide synthesis, featuring a pivaloyloxymethyl (PivOM) group protecting the 2'-hydroxyl group of uridine. This modification enhances stability during synthesis and can be removed under mild acidic conditions post-synthesis. The amidite functionality allows for the stepwise addition of this nucleotide in solid-phase synthesis, making it essential for creating RNA molecules with specific modifications for research and therapeutic applications.

CAT: BRP-00874

CAS: 1097131-15-1

MF: C45H57N4O11P

MF: 860.94

Purity: >95%

Appearance: Off-white solid

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InChIKey: CWFIVBQKXNPXJJ-WXSPLRIASA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OCOC(=O)C(C)(C)C)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: [(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-2-(2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxymethyl 2,2-dimethylpropanoate

InChI: InChI=1S/C45H57N4O11P/c1-30(2)49(31(3)4)61(58-27-13-25-46)60-39-37(59-41(48-26-24-38(50)47-43(48)52)40(39)55-29-56-42(51)44(5,6)7)28-57-45(32-14-11-10-12-15-32,33-16-20-35(53-8)21-17-33)34-18-22-36(54-9)23-19-34/h10-12,14-24,26,30-31,37,39-41H,13,27-29H2,1-9H3,(H,47,50,52)/t37-,39-,40-,41-,61?/m1/s1

Synonyms: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(2,2-dimethyl-1-oxopropoxy)methyl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; (((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)oxy)methyl pivalate; 2'-O-PivOM-5'-O-DMT-Uridine 3'-CEP

2'-OPivOM C(Ac) amidite

Description: 2'-O-PivOM C(Ac) amidite is a modified cytidine nucleotide used in oligonucleotide synthesis. It features a 2'-O-pivaloyloxymethyl group protecting the 2'-hydroxyl and an acetyl group protecting the amino group at the 4-position, facilitating stepwise addition during solid-phase synthesis. This allows for the creation of RNA molecules with specific modifications.

CAT: BRP-00875

CAS: 1097131-18-4

MF: C47H60N5O11P

MF: 902.00

Purity: >95%

Appearance: Off-white solid

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InChIKey: XGSYTNZPEKBGAM-JFALYFJISA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OCOC(=O)C(C)(C)C)N2C=CC(=NC2=O)NC(=O)C)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: [(2R,3R,4R,5R)-2-(4-acetamido-2-oxopyrimidin-1-yl)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-3-yl]oxymethyl 2,2-dimethylpropanoate

InChI: InChI=1S/C47H60N5O11P/c1-31(2)52(32(3)4)64(61-28-14-26-48)63-41-39(62-43(42(41)58-30-59-44(54)46(6,7)8)51-27-25-40(49-33(5)53)50-45(51)55)29-60-47(34-15-12-11-13-16-34,35-17-21-37(56-9)22-18-35)36-19-23-38(57-10)24-20-36/h11-13,15-25,27,31-32,39,41-43H,14,28-30H2,1-10H3,(H,49,50,53,55)/t39-,41-,42-,43-,64?/m1/s1

Synonyms: Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(2,2-dimethyl-1-oxopropoxy)methyl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; (((2R,3R,4R,5R)-2-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)tetrahydrofuran-3-yl)oxy)methyl pivalate; 2'-O-PivOM-5'-O-DMT-Cytidine (N-Ac) 3'-CEP

2'-OPivOM A(pac) amidite

Description: 2'-O-PivOM A(Pac) amidite is a modified adenosine nucleotide used in oligonucleotide synthesis. It includes a 2'-O-pivaloyloxymethyl group protecting the 2'-hydroxyl and a phenoxyacetyl (Pac) group protecting the exocyclic amino group at the N6 position, enabling precise incorporation during solid-phase synthesis for constructing RNA sequences with desired modifications.

CAT: BRP-00876

CAS: 1097131-21-9

MF: C54H64N7O11P

MF: 1018.12

Purity: >95%

Appearance: Off-white solid

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InChIKey: JMGAJBBCWCMKLV-PQTVSCHKSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OCOC(=O)C(C)(C)C)N2C=NC3=C(N=CN=C32)NC(=O)COC4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC

IUPAC Name: [(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-2-[6-[(2-phenoxyacetyl)amino]purin-9-yl]oxolan-3-yl]oxymethyl 2,2-dimethylpropanoate

InChI: InChI=1S/C54H64N7O11P/c1-36(2)61(37(3)4)73(70-30-16-29-55)72-47-44(31-69-54(38-17-12-10-13-18-38,39-21-25-41(64-8)26-22-39)40-23-27-42(65-9)28-24-40)71-51(48(47)67-35-68-52(63)53(5,6)7)60-34-58-46-49(56-33-57-50(46)60)59-45(62)32-66-43-19-14-11-15-20-43/h10-15,17-28,33-34,36-37,44,47-48,51H,16,30-32,35H2,1-9H3,(H,56,57,59,62)/t44-,47-,48-,51-,73?/m1/s1

Synonyms: Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(2,2-dimethyl-1-oxopropoxy)methyl]-N-(2-phenoxyacetyl)-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; (((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-2-(6-(2-phenoxyacetamido)-9H-purin-9-yl)tetrahydrofuran-3-yl)oxy)methyl pivalate; 2'-O-PivOM-5'-O-DMT-Adenosine (N-PAC) 3'-CEP

2'-OTBS A(Ac) amidite

Description: 2'-OTBS A(Ac) amidite is a specialized compound used in oligonucleotide synthesis. It contains a nucleoside derivative with a tert-butyldimethylsilyl (OTBS) group protecting the 2'-hydroxyl position of adenosine. Additionally, it features an acetyl (Ac) group attached to the amine group of the adenosine base. This compound enables controlled addition during oligonucleotide synthesis, allowing for precise customization and design of adenosine-modified oligonucleotides for various molecular biology applications, such as RNA interference (RNAi) studies and gene expression analysis.

CAT: BRP-00877

CAS: 1220889-84-8

MF: C48H64N7O8PSi

MF: 926.14

Purity: >98%

Appearance: Off-white solid

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InChIKey: IISGHHSYMWMWKH-FLEVKJGDSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=NC3=C(N=CN=C32)NC(=O)C)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]purin-6-yl]acetamide

InChI: InChI=1S/C48H64N7O8PSi/c1-32(2)55(33(3)4)64(60-28-16-27-49)62-42-40(61-46(43(42)63-65(11,12)47(6,7)8)54-31-52-41-44(53-34(5)56)50-30-51-45(41)54)29-59-48(35-17-14-13-15-18-35,36-19-23-38(57-9)24-20-36)37-21-25-39(58-10)26-22-37/h13-15,17-26,30-33,40,42-43,46H,16,28-29H2,1-12H3,(H,50,51,53,56)/t40-,42-,43-,46-,64?/m1/s1

Synonyms: Adenosine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(trimethylsilyl)-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; DMT-2'-O-TBDMS-A(Ac)-CE Phosphoramidite; 2'-O-TBDMS-A(Ac) CE Phosphoramidite; (2R,3R,4R,5R)-5-(6-Acetamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; 2'-tBDSilyl Adenosine (n-acetyl) CED phosphoramidite

2'-OTBS O6-NPE-I amidite

Description: 2'-OTBS O6-NPE-I amidite is a chemically modified phosphoramidite used in the synthesis of oligonucleotides. This compound features inosine as the nucleoside base, with an O6 position protected by a nitrophenylethyl (NPE) group. Additionally, the ribose sugar is protected at the 2' position with a tert-butyldimethylsilyl (TBS) group. This phosphoramidite is specifically designed for incorporation into DNA or RNA sequences during solid-phase oligonucleotide synthesis. The TBS and NPE protecting groups ensure selective deprotection, allowing for precise modifications of oligonucleotides. This modified amidite is useful in various research applications, including the study of nucleotide interactions, enzymatic processing of modified nucleotides, and the development of therapeutic oligonucleotides, particularly those requiring enhanced stability or specific chemical modifications.

CAT: BRP-00878

CAS: 151059-66-4

MF: C54H68N7O10PSi

MF: 1034.24

Purity: >98%

Appearance: Off-white solid

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InChIKey: ORFDMMXBXUZNMM-YYONJIEZSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(6-(4-nitrophenethoxy)-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C54H68N7O10PSi/c1-37(2)60(38(3)4)72(68-32-15-31-55)70-48-46(34-67-54(40-16-13-12-14-17-40,41-20-26-44(64-8)27-21-41)42-22-28-45(65-9)29-23-42)69-52(49(48)71-73(10,11)53(5,6)7)59-36-58-47-50(59)56-35-57-51(47)66-33-30-39-18-24-43(25-19-39)61(62)63/h12-14,16-29,35-38,46,48-49,52H,15,30,32-34H2,1-11H3/t46-,48-,49-,52-,72?/m1/s1

Synonyms: 5'-O-DMT-2'-O-TBDMS O6-NPE-I 3'-CE Phosphoramidite

2'-OTBS C(pac) amidite

Description: 2'-OTBS C(Pac) amidite is a specialized compound used in oligonucleotide synthesis. It consists of a nucleoside derivative with a tert-butyldimethylsilyl (OTBS) group protecting the 2'-hydroxyl position of cytidine. Additionally, it features a phenoxyacetyl (Pac) group attached to the amine group of the cytidine base. This compound facilitates controlled addition during oligonucleotide synthesis, enabling precise customization and design of cytidine-modified oligonucleotides for various molecular biology applications, including RNA interference (RNAi) studies, gene expression analysis, and antisense oligonucleotide design.

CAT: BRP-00879

CAS: 259144-69-9

MF: C53H68N5O10PSi

MF: 994.21

Purity: >98%

Appearance: Off-white solid

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InChIKey: HUTVBXXKUWIFOM-OPZOZVPWSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2-oxo-4-(2-phenoxyacetamido)pyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C53H68N5O10PSi/c1-37(2)58(38(3)4)69(65-34-18-32-54)67-48-45(35-64-53(39-19-14-12-15-20-39,40-23-27-42(61-8)28-24-40)41-25-29-43(62-9)30-26-41)66-50(49(48)68-70(10,11)52(5,6)7)57-33-31-46(56-51(57)60)55-47(59)36-63-44-21-16-13-17-22-44/h12-17,19-31,33,37-38,45,48-50H,18,34-36H2,1-11H3,(H,55,56,59,60)/t45-,48-,49-,50-,69?/m1/s1

Synonyms: 2'-tBDSilyl Cytidine (n-PAC) CED phosphoramidite; 2'-O-TBDMS C(pac) 3'-CE phosphoramidite

2'-OMe O6-NPE-I amidite

Description: 2'-OTBS O6-NPE-I amidite is a modified phosphoramidite used in oligonucleotide synthesis. It serves as a building block during solid-phase oligonucleotide synthesis, enabling the incorporation of nucleosides modified at the O6 position with NPE (nitrophenylethyl) functionality and protected with tert-butyldimethylsilyl (OTBS) into the oligonucleotide sequence. This compound is important for synthesizing oligonucleotides with specific modifications, which can be utilized in various applications such as molecular biology research, diagnostics, and therapeutics.

CAT: BRP-00880

MF: C49H56N7O10P

MF: 934.00

Purity: >95%

Appearance: Off-white solid

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InChIKey: WOXYNKAZRDURES-WBHVIXSUSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxy-5-(6-(4-nitrophenethoxy)-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C49H56N7O10P/c1-33(2)55(34(3)4)67(64-28-11-27-50)66-44-42(30-63-49(36-12-9-8-10-13-36,37-16-22-40(59-5)23-17-37)38-18-24-41(60-6)25-19-38)65-48(45(44)61-7)54-32-53-43-46(54)51-31-52-47(43)62-29-26-35-14-20-39(21-15-35)56(57)58/h8-10,12-25,31-34,42,44-45,48H,11,26,28-30H2,1-7H3/t42-,44-,45-,48-,67?/m1/s1

Synonyms: 5'-O-DMT-2'-O-Me O6-NPE-I 3'-CE Phosphoramidite

2'-OMe C(dmf) amidite

Description: 2'-OMe C(dmf) amidite is a modified phosphoramidite used in oligonucleotide synthesis. It serves as a building block during solid-phase oligonucleotide synthesis, enabling the incorporation of cytidine residues modified with 2'-methoxy and protected with dimethylformamidine (dmf) into the oligonucleotide sequence. This compound is essential for synthesizing oligonucleotides with specific modifications, which can be utilized in various applications such as molecular biology research, diagnostics, and therapeutics.

CAT: BRP-00881

MF: C43H55N6O8P

MF: 814.92

Purity: >98%

Appearance: Off-white solid

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InChIKey: ICEAPTWUNIADBV-PENKXTLKSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(4-(((dimethylamino)methylene)amino)-2-oxopyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C43H55N6O8P/c1-30(2)49(31(3)4)58(55-27-13-25-44)57-39-37(56-41(40(39)53-9)48-26-24-38(46-42(48)50)45-29-47(5)6)28-54-43(32-14-11-10-12-15-32,33-16-20-35(51-7)21-17-33)34-18-22-36(52-8)23-19-34/h10-12,14-24,26,29-31,37,39-41H,13,27-28H2,1-9H3/t37-,39-,40-,41-,58?/m1/s1

Synonyms: DMT-2'-O-Me-C(dmf)-CE Phosphoramidite; N4-Dimethylformamide-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-cytidine-3'-cyanoethyl phosphoramidite

2'-OMe A(dmf) amidite

Description: 2'-OMe A(dmf) amidite is a modified phosphoramidite used in oligonucleotide synthesis. It serves as a building block during solid-phase oligonucleotide synthesis, enabling the incorporation of adenine residues modified with 2'-methoxy and protected with dimethylformamidine (dmf) into the oligonucleotide sequence. This compound is crucial for synthesizing oligonucleotides with specific modifications, which can be utilized in various applications such as molecular biology research, diagnostics, and therapeutics.

CAT: BRP-00882

MF: C44H55N8O7P

MF: 838.95

Purity: >97%

Appearance: Off-white solid

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InChIKey: BKDZYCQEULBZAC-OOJSWXONSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(6-(((dimethylamino)methylene)amino)-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C44H55N8O7P/c1-30(2)52(31(3)4)60(57-25-13-24-45)59-39-37(58-43(40(39)55-9)51-29-48-38-41(49-28-50(5)6)46-27-47-42(38)51)26-56-44(32-14-11-10-12-15-32,33-16-20-35(53-7)21-17-33)34-18-22-36(54-8)23-19-34/h10-12,14-23,27-31,37,39-40,43H,13,25-26H2,1-9H3/t37-,39-,40-,43-,60?/m1/s1

Synonyms: 2'-OMe A(dmf) phosphoramidite; 2'-OMe-A(dmf) CE-Phosphoramidite; 5'-O-DMTr-2'-O-Methyl-A(dmf)-3'-CE-Phosphoramidite

2'-OMe C(pac) amidite

Description: 2'-OMe C(pac) amidite is a modified phosphoramidite used in oligonucleotide synthesis. It serves as a building block during solid-phase oligonucleotide synthesis, enabling the incorporation of cytidine residues modified with 2'-methoxy and protected with phenoxyacetyl (pac) into the oligonucleotide sequence. This compound is essential for synthesizing oligonucleotides with specific modifications, which can be utilized in various applications such as molecular biology research, diagnostics, and therapeutics.

CAT: BRP-00883

MF: C48H56N5O10P

MF: 893.98

Purity: >98%

Appearance: Off-white solid

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InChIKey: YHPPPUPQDGDFOB-KPYWRNADSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxy-5-(2-oxo-4-(2-phenoxyacetamido)pyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C48H56N5O10P/c1-33(2)53(34(3)4)64(61-30-14-28-49)63-44-41(62-46(45(44)58-7)52-29-27-42(51-47(52)55)50-43(54)32-59-40-17-12-9-13-18-40)31-60-48(35-15-10-8-11-16-35,36-19-23-38(56-5)24-20-36)37-21-25-39(57-6)26-22-37/h8-13,15-27,29,33-34,41,44-46H,14,30-32H2,1-7H3,(H,50,51,54,55)/t41-,44-,45-,46-,64?/m1/s1

Synonyms: 2'-OMe C(pac) phosphoramidite; 2'-OMe-C(pac) CE-Phosphoramidite; 2'-O-Methyl Cytidine (n-PAC) CED phosphoramidite; 5'-O-DMTr-2'-O-Methyl-C(Pac)-3'-CE-Phosphoramidite

2'-OMe MeC(pac) amidite

Description: 2'-OMe MeC(pac) amidite is a modified phosphoramidite used in oligonucleotide synthesis. It serves as a building block during solid-phase oligonucleotide synthesis, allowing the incorporation of cytidine residues modified with 2'-methoxy and protected with phenoxyacetyl (pac) into the oligonucleotide sequence. This compound is crucial for synthesizing oligonucleotides with specific modifications, which can be utilized in various applications such as molecular biology research, diagnostics, and therapeutics.

CAT: BRP-00884

MF: C49H58N5O10P

MF: 908.00

Purity: >98%

Appearance: Off-white solid

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InChIKey: NBZIVLMTLZOAQR-NXPFYNPLSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxy-5-(5-methyl-2-oxo-4-(2-phenoxyacetamido)pyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C49H58N5O10P/c1-33(2)54(34(3)4)65(62-29-15-28-50)64-44-42(63-47(45(44)59-8)53-30-35(5)46(52-48(53)56)51-43(55)32-60-41-18-13-10-14-19-41)31-61-49(36-16-11-9-12-17-36,37-20-24-39(57-6)25-21-37)38-22-26-40(58-7)27-23-38/h9-14,16-27,30,33-34,42,44-45,47H,15,29,31-32H2,1-8H3,(H,51,52,55,56)/t42-,44-,45-,47-,65?/m1/s1

Synonyms: 2'-OMe-MeC(pac) CE-Phosphoramidite

2'-OTFM A(Bz) amidite

Description: 2'-OTFM A(Bz) amidite is a modified phosphoramidite used in oligonucleotide synthesis. It serves as a building block during solid-phase oligonucleotide synthesis, enabling the incorporation of adenine residues modified with 2'-O-trifluoromethyl (2'-OTFM) and protected with benzoyl (Bz) into the oligonucleotide sequence. This compound is essential for synthesizing oligonucleotides with specific modifications, which can be utilized in various applications such as molecular biology research, diagnostics, and therapeutics.

CAT: BRP-00885

CAS: 220322-52-1

MF: C48H51F3N7O8P

MF: 941.95

Purity: >95%

Appearance: Off-white solid

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InChIKey: LFGLQKDVVQKUSX-OPRMLWSSSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OC(F)(F)F)N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-(trifluoromethoxy)oxolan-2-yl]purin-6-yl]benzamide

InChI: InChI=1S/C48H51F3N7O8P/c1-31(2)58(32(3)4)67(63-27-13-26-52)66-41-39(28-62-47(34-16-11-8-12-17-34,35-18-22-37(60-5)23-19-35)36-20-24-38(61-6)25-21-36)64-46(42(41)65-48(49,50)51)57-30-55-40-43(53-29-54-44(40)57)56-45(59)33-14-9-7-10-15-33/h7-12,14-25,29-32,39,41-42,46H,13,27-28H2,1-6H3,(H,53,54,56,59)/t39-,41-,42-,46-,67?/m1/s1

Synonyms: Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(trifluoromethyl)-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(trifluoromethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

2'-propargyl G(Ac) amidite

Description: 2'-propargyl G(Ac) amidite is a modified phosphoramidite used in oligonucleotide synthesis. It serves as a building block during solid-phase oligonucleotide synthesis, allowing the incorporation of guanine residues modified with a propargyl group at the 2' position and protected with acetyl (Ac) into the oligonucleotide sequence. This compound is crucial for synthesizing oligonucleotides with specific modifications, which can be utilized in various applications such as molecular biology research, diagnostics, and therapeutics.

CAT: BRP-00886

MF: C45H52N7O9P

MF: 865.93

Purity: >95%

Appearance: White, off-white to faint yellow powder

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InChIKey: HJFWRIKHRWBAKQ-GDLAVZMWSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4R,5R)-5-(2-acetamido-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(prop-2-yn-1-yloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C45H52N7O9P/c1-9-25-57-40-39(61-62(59-26-13-24-46)52(29(2)3)30(4)5)37(60-43(40)51-28-47-38-41(51)49-44(48-31(6)53)50-42(38)54)27-58-45(32-14-11-10-12-15-32,33-16-20-35(55-7)21-17-33)34-18-22-36(56-8)23-19-34/h1,10-12,14-23,28-30,37,39-40,43H,13,25-27H2,2-8H3,(H2,48,49,50,53,54)/t37-,39-,40-,43-,62?/m1/s1

Synonyms: N2-Ac-DMT-2'-O-propargyl-G-CE-Phosphoramidite; [N2-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-propargyl-guanosine]-3'-[(2-cyanoethyl)-N,N-diisopropyl]phosphoramidite

2'-propargyl A(pac) amidite

Description: 2'-propargyl A(pac) amidite is a modified phosphoramidite used in oligonucleotide synthesis. It serves as a building block during solid-phase oligonucleotide synthesis, enabling the incorporation of adenine residues modified with a propargyl group at the 2' position and protected with pac (phenoxyacetyl) into the oligonucleotide sequence. This compound is essential for synthesizing oligonucleotides with specific modifications, which can be utilized in various applications such as molecular biology research, diagnostics, and therapeutics.

CAT: BRP-00887

MF: C51H56N7O9P

MF: 942.02

Purity: >95%

Appearance: Off-white solid

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InChIKey: IACAIOROZYTJFW-KJMRTUCVSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(6-(2-phenoxyacetamido)-9H-purin-9-yl)-4-(prop-2-yn-1-yloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C51H56N7O9P/c1-8-29-62-47-46(67-68(65-30-15-28-52)58(35(2)3)36(4)5)43(66-50(47)57-34-55-45-48(53-33-54-49(45)57)56-44(59)32-63-42-18-13-10-14-19-42)31-64-51(37-16-11-9-12-17-37,38-20-24-40(60-6)25-21-38)39-22-26-41(61-7)27-23-39/h1,9-14,16-27,33-36,43,46-47,50H,15,29-32H2,2-7H3,(H,53,54,56,59)/t43-,46-,47-,50-,68?/m1/s1

Synonyms: 2'-propargyl-Pac-A-CE Phosphoramidite

2'-OTBS A(di-Me) amidite

Description: 2'-OTBS A(di-Me) amidite is commonly used in the synthesis of RNA molecules through solid-phase synthesis. This phosphoramidite derivative contains a 2'-O-TBDMS (tert-butyldimethylsilyl) and a 3'-O-CE (2-cyanoethyl) protecting groups, which can be removed under specific conditions after synthesis. The N6,N6-Dimethyl modification on the adenine base can also enhance the specificity and selectivity of RNA interactions with target molecules. This modified adenosine derivative can improve the stability and binding affinity of RNA molecules in various applications such as antisense therapy, RNA interference, and aptamer development.

CAT: BRP-00888

MF: C48H66N7O7PSi

MF: 912.16

Purity: >95%

Appearance: Off-white solid

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InChIKey: FOBJTSYXSOCKFB-OKNPHDNFSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(6-(dimethylamino)-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C48H66N7O7PSi/c1-33(2)55(34(3)4)63(59-29-17-28-49)61-42-40(60-46(43(42)62-64(12,13)47(5,6)7)54-32-52-41-44(53(8)9)50-31-51-45(41)54)30-58-48(35-18-15-14-16-19-35,36-20-24-38(56-10)25-21-36)37-22-26-39(57-11)27-23-37/h14-16,18-27,31-34,40,42-43,46H,17,29-30H2,1-13H3/t40-,42-,43-,46-,63?/m1/s1

Synonyms: N6,N6-Dimethyl Adenosine 2'-TBDMS-3'-CEP; N6,N6-Dimethyl 2'-TBDMS rA 3'-CE phosphoramidite

2'-OTBS N1-Me-A(ClAc) amidite

Description: 2'-OTBS N1-Me-A(ClAc) amidite is a modified phosphoramidite used in oligonucleotide synthesis. It serves as a building block during solid-phase oligonucleotide synthesis, enabling the incorporation of adenine residues modified with a methyl group at the N1 position and protected with chloroacetyl (ClAc) at the amino group into the oligonucleotide sequence. This compound is essential for synthesizing oligonucleotides with specific modifications, which can be utilized in various applications such as molecular biology research, diagnostics, and therapeutics.

CAT: BRP-00889

MF: C49H65ClN7O8PSi

MF: 974.61

Purity: >95%

Appearance: Off-white solid

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InChIKey: ISUKAHYBQLYEAJ-VPFLNFIBSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(6-((2-chloroacetyl)imino)-1-methyl-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C49H65ClN7O8PSi/c1-33(2)57(34(3)4)66(62-28-16-27-51)64-43-40(30-61-49(35-17-14-13-15-18-35,36-19-23-38(59-9)24-20-36)37-21-25-39(60-10)26-22-37)63-47(44(43)65-67(11,12)48(5,6)7)56-32-52-42-45(56)53-31-55(8)46(42)54-41(58)29-50/h13-15,17-26,31-34,40,43-44,47H,16,28-30H2,1-12H3/t40-,43-,44-,47-,66?/m1/s1

Synonyms: 5'-O-DMT-2'-O-TBDMS N1-Me-A(ClAc) 3'-CE Phosphoramidite