Phosphoramidites - RNA / BOC Sciences

2'-OMe G(iBu) (TBSO)SATE-amidite

Description: 2'-OMe G(iBu) (TBSO)SATE-amidite is a reagent used in oligonucleotide synthesis. It contains a methyl (Me) group at the 2' position of ribose, guanosine (G) potentially protected with an isobutyl (iBu) group. This reagent enables the controlled synthesis of modified oligonucleotides with enhanced stability and specific functionalities.

CAT: BRP-00939

MF: C55H79N6O11PSSi

MF: 1091.40

Purity: >95%

Appearance: Off-white solid

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InChIKey: KNYQSRGOAUUKQY-HYFQDGRXSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: S-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethyl) 3-((tert-butyldimethylsilyl)oxy)-2,2-dimethylpropanethioate

InChI: InChI=1S/C55H79N6O11PSSi/c1-35(2)48(62)58-52-57-47-44(49(63)59-52)56-34-60(47)50-46(67-14)45(72-73(61(36(3)4)37(5)6)69-30-31-74-51(64)54(10,11)33-70-75(15,16)53(7,8)9)43(71-50)32-68-55(38-20-18-17-19-21-38,39-22-26-41(65-12)27-23-39)40-24-28-42(66-13)29-25-40/h17-29,34-37,43,45-46,50H,30-33H2,1-16H3,(H2,57,58,59,62,63)/t43-,45-,46-,50-,73?/m1/s1

2'-OMe A(Bz) (TBSO)SATE-amidite

Description: 2'-OMe A(Bz) (TBSO)SATE-amidite is a reagent utilized in oligonucleotide synthesis. It contains a methyl (Me) group at the 2' position of ribose, adenine (A) potentially protected with a benzoyl (Bz) group. This reagent enables the controlled synthesis of modified oligonucleotides with improved stability and specific functionalities.

CAT: BRP-00940

MF: C58H77N6O10PSSi

MF: 1109.41

Purity: >95%

Appearance: Off-white solid

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InChIKey: BPRJNTIBJAXHFE-SLDILDNQSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: S-(2-(((((2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethyl) 3-((tert-butyldimethylsilyl)oxy)-2,2-dimethylpropanethioate

InChI: InChI=1S/C58H77N6O10PSSi/c1-39(2)64(40(3)4)75(71-33-34-76-55(66)57(8,9)36-72-77(13,14)56(5,6)7)74-49-47(73-54(50(49)69-12)63-38-61-48-51(59-37-60-52(48)63)62-53(65)41-21-17-15-18-22-41)35-70-58(42-23-19-16-20-24-42,43-25-29-45(67-10)30-26-43)44-27-31-46(68-11)32-28-44/h15-32,37-40,47,49-50,54H,33-36H2,1-14H3,(H,59,60,62,65)/t47-,49-,50-,54-,75?/m1/s1

2'-OMe C(Bz) (TBSO)SATE-amidite

Description: 2'-OMe C(Bz) (TBSO)SATE-amidite is a reagent used in oligonucleotide synthesis. It contains a methyl (Me) group at the 2' position of ribose, cytosine (C) potentially protected with a benzoyl (Bz) group. This reagent facilitates the controlled synthesis of modified oligonucleotides with enhanced stability and specific functionalities.

CAT: BRP-00941

MF: C57H77N4O11PSSi

MF: 1085.39

Purity: >95%

Appearance: Off-white solid

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InChIKey: IGTHQWLLAPOEKK-LEOYGVFQSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: S-(2-(((((2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethyl) 3-((tert-butyldimethylsilyl)oxy)-2,2-dimethylpropanethioate

InChI: InChI=1S/C57H77N4O11PSSi/c1-39(2)61(40(3)4)73(69-35-36-74-53(63)56(8,9)38-70-75(13,14)55(5,6)7)72-49-47(71-52(50(49)67-12)60-34-33-48(59-54(60)64)58-51(62)41-21-17-15-18-22-41)37-68-57(42-23-19-16-20-24-42,43-25-29-45(65-10)30-26-43)44-27-31-46(66-11)32-28-44/h15-34,39-40,47,49-50,52H,35-38H2,1-14H3,(H,58,59,62,64)/t47-,49-,50-,52-,73?/m1/s1

2'-OMe U (TBSO)SATE-amidite

Description: 2'-OMe U (TBSO)SATE-amidite is a reagent utilized in oligonucleotide synthesis. It contains a methyl (Me) group at the 2' position of ribose and incorporates uracil (U). This reagent facilitates the controlled synthesis of modified oligonucleotides with enhanced stability and specific functionalities, possibly through the introduction of protecting groups or linkers.

CAT: BRP-00942

MF: C50H72N3O11PSSi

MF: 982.26

Purity: >95%

Appearance: Off-white solid

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InChIKey: JPIPEHQBJWFYBS-DLBBVOJMSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: S-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethyl) 3-((tert-butyldimethylsilyl)oxy)-2,2-dimethylpropanethioate

InChI: InChI=1S/C50H72N3O11PSSi/c1-34(2)53(35(3)4)65(61-30-31-66-46(55)49(8,9)33-62-67(13,14)48(5,6)7)64-43-41(63-45(44(43)59-12)52-29-28-42(54)51-47(52)56)32-60-50(36-18-16-15-17-19-36,37-20-24-39(57-10)25-21-37)38-22-26-40(58-11)27-23-38/h15-29,34-35,41,43-45H,30-33H2,1-14H3,(H,51,54,56)/t41-,43-,44-,45-,65?/m1/s1

2'-OMe U PACE amidite

Description: 2'-OMe U PACE amidite is a reagent employed in oligonucleotide synthesis. It features a methyl (Me) group at the 2' position of ribose and contains uracil (U). ''PACE'' likely refers to a specific modification or functional group incorporated into the nucleotide. This reagent facilitates the controlled synthesis of modified oligonucleotides with specific properties or functionalities, although the exact nature of ''PACE'' would determine its specific role in the synthesis process.

CAT: BRP-00943

CAS: 411234-28-1

MF: C44H55N4O10P

MF: 830.92

Purity: >98%

Appearance: White to off-white powder

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InChIKey: KZVIZOJLWDQWHO-VJPJVJEPSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(CC(=O)OC(C)(C)CC#N)OC1C(OC(C1OC)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: (1-cyano-2-methylpropan-2-yl) 2-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(2,4-dioxopyrimidin-1-yl)-4-methoxyoxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]acetate

InChI: InChI=1S/C44H55N4O10P/c1-29(2)48(30(3)4)59(28-38(50)57-43(5,6)24-25-45)58-39-36(56-41(40(39)54-9)47-26-23-37(49)46-42(47)51)27-55-44(31-13-11-10-12-14-31,32-15-19-34(52-7)20-16-32)33-17-21-35(53-8)22-18-33/h10-23,26,29-30,36,39-41H,24,27-28H2,1-9H3,(H,46,49,51)/t36-,39-,40-,41-,59?/m1/s1

Synonyms: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[P-[2-(2-cyano-1,1-dimethylethoxy)-2-oxoethyl]-N,N-bis(1-methylethyl)phosphonamidite]; 1-cyano-2-methylpropan-2-yl 2-((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)acetate; 5'-O-DMTr-2'-O-Me-U PACE; 3'-O-(Diisopropylamino)phosphinoacetic acid α,α-dimethyl-β-cyanoethyl methyl ester 5'-O-(4,4'-dimethoxytrityl)-2'-O-methyluridine

2'-OMe C(Ac) PACE amidite

Description: 2'-OMe C(Ac) PACE amidite is a reagent used in oligonucleotide synthesis. It contains a methyl (Me) group at the 2' position of ribose, cytosine (C) potentially protected with an acetyl (Ac) group, and incorporates a modification referred to as ''PACE''. This modification might introduce specific functionalities or properties to the oligonucleotide. The exact nature of ''PACE'' would determine its role in the synthesis process and the properties of the resulting oligonucleotide.

CAT: BRP-00944

CAS: 1355047-25-4

MF: C46H58N5O10P

MF: 871.97

Purity: >98%

Appearance: White solid

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InChIKey: RQLMSVYEXLXTTN-YQKQXIHOSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(CC(=O)OC(C)(C)CC#N)OC1C(OC(C1OC)N2C=CC(=NC2=O)NC(=O)C)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: (1-cyano-2-methylpropan-2-yl) 2-[[(2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1-yl)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-methoxyoxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]acetate

InChI: InChI=1S/C46H58N5O10P/c1-30(2)51(31(3)4)62(29-40(53)60-45(6,7)25-26-47)61-41-38(59-43(42(41)57-10)50-27-24-39(48-32(5)52)49-44(50)54)28-58-46(33-14-12-11-13-15-33,34-16-20-36(55-8)21-17-34)35-18-22-37(56-9)23-19-35/h11-24,27,30-31,38,41-43H,25,28-29H2,1-10H3,(H,48,49,52,54)/t38-,41-,42-,43-,62?/m1/s1

Synonyms: Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[P-[2-(2-cyano-1,1-dimethylethoxy)-2-oxoethyl]-N,N-bis(1-methylethyl)phosphonamidite]; 1-cyano-2-methylpropan-2-yl 2-((((2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)acetate; 5'-O-DMTr-2'-O-Me-C(Ac) PACE; 3'-O-(Diisopropylamino)phosphinoacetic acid α,α-dimethyl-β-cyanoethyl methyl ester N4-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methylcytidine

2'-OMe A(Bz) PACE amidite

Description: 2'-OMe A(Bz) PACE amidite is a reagent utilized in oligonucleotide synthesis. It contains a methyl (Me) group at the 2' position of ribose, adenine (A) potentially protected with a benzoyl (Bz) group, and incorporates a modification known as ''PACE''. This modification introduces specific functionalities or properties to the oligonucleotide. The exact nature of ''PACE'' would dictate its role in the synthesis process and the characteristics of the resulting oligonucleotide.

CAT: BRP-00945

CAS: 1355047-24-3

MF: C52H60N7O9P

MF: 958.07

Purity: >97%

Appearance: White solid

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InChIKey: JWEJRQXHPXDTPT-GCZIAXJXSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(CC(=O)OC(C)(C)CC#N)OC1C(OC(C1OC)N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC

IUPAC Name: (1-cyano-2-methylpropan-2-yl) 2-[[(2R,3R,4R,5R)-5-(6-benzamidopurin-9-yl)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-methoxyoxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]acetate

InChI: InChI=1S/C52H60N7O9P/c1-34(2)59(35(3)4)69(31-43(60)67-51(5,6)28-29-53)68-45-42(66-50(46(45)64-9)58-33-56-44-47(54-32-55-48(44)58)57-49(61)36-16-12-10-13-17-36)30-65-52(37-18-14-11-15-19-37,38-20-24-40(62-7)25-21-38)39-22-26-41(63-8)27-23-39/h10-27,32-35,42,45-46,50H,28,30-31H2,1-9H3,(H,54,55,57,61)/t42-,45-,46-,50-,69?/m1/s1

Synonyms: Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[P-[2-(2-cyano-1,1-dimethylethoxy)-2-oxoethyl]-N,N-bis(1-methylethyl)phosphonamidite]; 1-cyano-2-methylpropan-2-yl 2-((((2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)acetate

2'-OMe G(iBu) PACE amidite

Description: 2'-OMe G(iBu) PACE amidite is a reagent used in oligonucleotide synthesis. It contains a methyl (Me) group at the 2' position of ribose, guanosine (G) potentially protected with an isobutyl (iBu) group, and incorporates a modification referred to as ''PACE''. This modification introduces specific functionalities or properties to the oligonucleotide. The exact nature of ''PACE'' would determine its role in the synthesis process and the characteristics of the resulting oligonucleotide.

CAT: BRP-00946

CAS: 1355047-26-5

MF: C49H62N7O10P

MF: 940.05

Purity: >98%

Appearance: White solid

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InChIKey: IEFSKQYVGBGNHJ-GGUIJGGTSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(CC(=O)OC(C)(C)CC#N)N(C(C)C)C(C)C)OC

IUPAC Name: (1-cyano-2-methylpropan-2-yl) 2-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-methoxy-5-[2-(2-methylpropanoylamino)-6-oxo-1H-purin-9-yl]oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]acetate

InChI: InChI=1S/C49H62N7O10P/c1-30(2)44(58)53-47-52-43-40(45(59)54-47)51-29-55(43)46-42(62-11)41(66-67(56(31(3)4)32(5)6)28-39(57)65-48(7,8)25-26-50)38(64-46)27-63-49(33-15-13-12-14-16-33,34-17-21-36(60-9)22-18-34)35-19-23-37(61-10)24-20-35/h12-24,29-32,38,41-42,46H,25,27-28H2,1-11H3,(H2,52,53,54,58,59)/t38-,41-,42-,46-,67?/m1/s1

Synonyms: Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-N-(2-methyl-1-oxopropyl)-, 3'-[P-[2-(2-cyano-1,1-dimethylethoxy)-2-oxoethyl]-N,N-bis(1-methylethyl)phosphonamidite]; 1-cyano-2-methylpropan-2-yl 2-((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)acetate

2'-OTBS U ThioPhosphamidite

Description: 2'-OTBS U ThioPhosphamidite is a reagent used in oligonucleotide synthesis. It contains a tert-butyldimethylsilyl (TBS) protecting group at the 2' position of ribose, uracil (U), and incorporates a thio modification. ThioPhosphamidite suggests the presence of a phosphoramidite moiety with a thiol (-SH) group attached. This reagent allows for the controlled synthesis of oligonucleotides with thio modifications, which can impart specific chemical or biological properties to the resulting oligonucleotide sequences.

CAT: BRP-00947

CAS: 1374755-68-6

MF: C49H60N3O9PS2Si

MF: 958.23

Purity: >98%

Appearance: Off-white solid

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InChIKey: CSXWIDBTNRBSQY-CRHOWCKESA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)(C)[Si](C)(C)OC1C(C(OC1N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OP(N6CCCC6)SCCSC(=O)C7=CC=CC=C7

IUPAC Name: S-[2-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-5-(2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-pyrrolidin-1-ylphosphanyl]sulfanylethyl] benzenecarbothioate

InChI: InChI=1S/C49H60N3O9PS2Si/c1-48(2,3)65(6,7)61-44-43(60-62(51-29-14-15-30-51)64-33-32-63-46(54)35-16-10-8-11-17-35)41(59-45(44)52-31-28-42(53)50-47(52)55)34-58-49(36-18-12-9-13-19-36,37-20-24-39(56-4)25-21-37)38-22-26-40(57-5)27-23-38/h8-13,16-28,31,41,43-45H,14-15,29-30,32-34H2,1-7H3,(H,50,53,55)/t41-,43-,44-,45-,62?/m1/s1

Synonyms: 5'-DMT-2'-OTBS-U-3'-PS-Phosphoramidite; DMT-2'-OTBS-U-3'-PS; S-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)oxy)(pyrrolidin-1-yl)phosphaneyl)thio)ethyl) benzothioate; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-[S-[2-(benzoylthio)ethyl] P-1-pyrrolidinylphosphonothioite]

2'-OTBS A(Bz) ThioPhosphamidite

Description: 2'-OTBS A(Bz) ThioPhosphamidite is a reagent used in oligonucleotide synthesis. It contains a tert-butyldimethylsilyl (TBS) protecting group at the 2' position of ribose, adenine (A) potentially protected with a benzoyl (Bz) group, and incorporates a thio modification. ThioPhosphamidite suggests the presence of a phosphoramidite moiety with a thiol (-SH) group attached. This reagent enables the controlled synthesis of oligonucleotides with thio modifications, offering specific chemical or biological functionalities to the resulting sequences.

CAT: BRP-00948

CAS: 1374755-65-3

MF: C57H65N6O8PS2Si

MF: 1085.38

Purity: >95%

Appearance: Off-white solid

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InChIKey: ALJIYXCITZABFP-WOMFGPHHSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)(C)[Si](C)(C)OC1C(C(OC1N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC)OP(N8CCCC8)SCCSC(=O)C9=CC=CC=C9

IUPAC Name: S-[2-[[(2R,3R,4R,5R)-5-(6-benzamidopurin-9-yl)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxyoxolan-3-yl]oxy-pyrrolidin-1-ylphosphanyl]sulfanylethyl] benzenecarbothioate

InChI: InChI=1S/C57H65N6O8PS2Si/c1-56(2,3)75(6,7)71-50-49(70-72(62-33-17-18-34-62)74-36-35-73-55(65)41-21-13-9-14-22-41)47(69-54(50)63-39-60-48-51(58-38-59-52(48)63)61-53(64)40-19-11-8-12-20-40)37-68-57(42-23-15-10-16-24-42,43-25-29-45(66-4)30-26-43)44-27-31-46(67-5)32-28-44/h8-16,19-32,38-39,47,49-50,54H,17-18,33-37H2,1-7H3,(H,58,59,61,64)/t47-,49-,50-,54-,72?/m1/s1

Synonyms: 5'-DMT-2'-OTBS-A(Bz)-3'-PS-Phosphoramidite; S-(2-(((((2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl)oxy)(pyrrolidin-1-yl)phosphaneyl)thio)ethyl) benzothioate; Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-[S-[2-(benzoylthio)ethyl] P-1-pyrrolidinylphosphonothioite]; DMT-2'-OTBS-A(Bz)-3'-PS

2'-OTBS C(Ac) ThioPhosphamidite

Description: 2'-OTBS C(Ac) ThioPhosphamidite is a reagent used in oligonucleotide synthesis. It contains a tert-butyldimethylsilyl (TBS) protecting group at the 2' position of ribose, cytosine (C) potentially protected with an acetyl (Ac) group, and incorporates a thio modification. ThioPhosphamidite suggests the presence of a phosphoramidite moiety with a thiol (-SH) group attached. This reagent facilitates the controlled synthesis of oligonucleotides with thio modifications, providing specific chemical or biological functionalities to the resulting sequences.

CAT: BRP-00949

CAS: 1374755-66-4

MF: C51H63N4O9PS2Si

MF: 999.28

Purity: >98%

Appearance: Off-white solid

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InChIKey: KEDMUXPEKPOPCR-YTFDKTRSSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(=O)NC1=NC(=O)N(C=C1)C2C(C(C(O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OP(N6CCCC6)SCCSC(=O)C7=CC=CC=C7)O[Si](C)(C)C(C)(C)C

IUPAC Name: S-[2-[[(2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1-yl)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxyoxolan-3-yl]oxy-pyrrolidin-1-ylphosphanyl]sulfanylethyl] benzenecarbothioate

InChI: InChI=1S/C51H63N4O9PS2Si/c1-36(56)52-44-29-32-55(49(58)53-44)47-46(64-68(7,8)50(2,3)4)45(63-65(54-30-15-16-31-54)67-34-33-66-48(57)37-17-11-9-12-18-37)43(62-47)35-61-51(38-19-13-10-14-20-38,39-21-25-41(59-5)26-22-39)40-23-27-42(60-6)28-24-40/h9-14,17-29,32,43,45-47H,15-16,30-31,33-35H2,1-8H3,(H,52,53,56,58)/t43-,45-,46-,47-,65?/m1/s1

Synonyms: 5'-DMT-2'-OTBS-C(Ac)-3'-PS-Phosphoramidite; DMT-2'-OTBS-C(Ac)-3'-PS; Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-[S-[2-(benzoylthio)ethyl] P-1-pyrrolidinylphosphonothioite]; S-(2-(((((2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl)oxy)(pyrrolidin-1-yl)phosphaneyl)thio)ethyl) benzothioate

2'-OTBS G(iBu) ThioPhosphamidite

Description: 2'-OTBS G(iBu) ThioPhosphamidite is a reagent used in oligonucleotide synthesis. It contains a tert-butyldimethylsilyl (TBS) protecting group at the 2' position of ribose, guanosine (G) potentially protected with an isobutyl (iBu) group, and incorporates a thio modification. ThioPhosphamidite suggests the presence of a phosphoramidite moiety with a thiol (-SH) group attached. This reagent enables the controlled synthesis of oligonucleotides with thio modifications, providing specific chemical or biological functionalities to the resulting sequences.

CAT: BRP-00950

MF: C54H67N6O9PS2Si

MF: 1067.36

Purity: >95%

Appearance: Off-white solid

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InChIKey: HXMLZPZNEIUXMQ-UFCBNZGASA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: S-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl)oxy)(pyrrolidin-1-yl)phosphaneyl)thio)ethyl) benzothioate

InChI: InChI=1S/C54H67N6O9PS2Si/c1-36(2)48(61)57-52-56-47-44(49(62)58-52)55-35-60(47)50-46(69-73(8,9)53(3,4)5)45(68-70(59-30-16-17-31-59)72-33-32-71-51(63)37-18-12-10-13-19-37)43(67-50)34-66-54(38-20-14-11-15-21-38,39-22-26-41(64-6)27-23-39)40-24-28-42(65-7)29-25-40/h10-15,18-29,35-36,43,45-46,50H,16-17,30-34H2,1-9H3,(H2,56,57,58,61,62)/t43-,45-,46-,50-,70?/m1/s1

Synonyms: 5'-DMT-2'-OTBS-G(iBu)-3'-PS-Phosphoramidite; DMT-2'-OTBS-G(iBu)-3'-PS

SNA C(Bz) amidite

Description: SNA C(Bz) amidite is a reagent used in solid-phase oligonucleotide synthesis, particularly in the synthesis of SNA (serinol nucleic acid) oligomers. It contains cytosine (C) with a benzoyl (Bz) protecting group attached to the amino group of the nucleobase, allowing for controlled coupling reactions during synthesis. SNA, or serinol nucleic acid, is a type of nucleic acid analog. This reagent facilitates the synthesis of SNA oligonucleotides, which have applications in various biotechnological and therapeutic areas due to their unique properties.

CAT: BRP-00951

CAS: 1280548-93-7

MF: C46H53N6O8P

MF: 848.94

Purity: >98%

Appearance: Off-white solid

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InChIKey: XRUGORVLABOZAD-PPCUMKKXSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: N#CCCOP(OCC(NC(=O)CN1C=CC(=NC1=O)NC(=O)C=2C=CC=CC2)COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)N(C(C)C)C(C)C

IUPAC Name: (S)-2-(2-(4-benzamido-2-oxopyrimidin-1(2H)-yl)acetamido)-3-(bis(4-methoxyphenyl)(phenyl)methoxy)propyl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C46H53N6O8P/c1-33(2)52(34(3)4)61(59-29-13-27-47)60-32-39(48-43(53)30-51-28-26-42(50-45(51)55)49-44(54)35-14-9-7-10-15-35)31-58-46(36-16-11-8-12-17-36,37-18-22-40(56-5)23-19-37)38-20-24-41(57-6)25-21-38/h7-12,14-26,28,33-34,39H,13,29-32H2,1-6H3,(H,48,53)(H,49,50,54,55)/t39-,61?/m0/s1

Synonyms: Phosphoramidous acid, N,N-bis(1-methylethyl)-, (2S)-2-[[2-[4-(benzoylamino)-2-oxo-1(2H)-pyrimidinyl]acetyl]amino]-3-[bis(4-methoxyphenyl)phenylmethoxy]propyl 2-cyanoethyl ester; (2S)-2-[[2-[4-(Benzoylamino)-2-oxo-1(2H)-pyrimidinyl]acetyl]amino]-3-[bis(4-methoxyphenyl)phenylmethoxy]propyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite; (S)-SNA-C(Bz) Phosphoramidite

SNA A(Bz) amidite

Description: SNA A(Bz) amidite is a reagent used in solid-phase oligonucleotide synthesis, particularly for synthesizing SNA (serinol nucleic acid) oligomers. It contains adenine (A) with a benzoyl (Bz) protecting group attached to the amino group of the nucleobase, enabling controlled coupling reactions during synthesis. This reagent facilitates the synthesis of SNA oligonucleotides, which are nucleic acid analogs with modified backbone structures. SNA oligomers have applications in various fields such as molecular biology, diagnostics, and therapeutics due to their unique properties and potential functionalities.

CAT: BRP-00952

CAS: 1280548-94-8

MF: C47H53N8O7P

MF: 872.96

Purity: >97%

Appearance: Off-white solid

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InChIKey: ALIIACZLWAKPSI-QGGVFJROSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: N#CCCOP(OCC(NC(=O)CN1C=NC=2C(=NC=NC21)NC(=O)C=3C=CC=CC3)COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C

IUPAC Name: (S)-2-(2-(6-benzamido-9H-purin-9-yl)acetamido)-3-(bis(4-methoxyphenyl)(phenyl)methoxy)propyl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C47H53N8O7P/c1-33(2)55(34(3)4)63(61-27-13-26-48)62-30-39(52-42(56)28-54-32-51-43-44(49-31-50-45(43)54)53-46(57)35-14-9-7-10-15-35)29-60-47(36-16-11-8-12-17-36,37-18-22-40(58-5)23-19-37)38-20-24-41(59-6)25-21-38/h7-12,14-25,31-34,39H,13,27-30H2,1-6H3,(H,52,56)(H,49,50,53,57)/t39-,63?/m0/s1

Synonyms: Phosphoramidous acid, N,N-bis(1-methylethyl)-, (2S)-2-[[2-[6-(benzoylamino)-9H-purin-9-yl]acetyl]amino]-3-[bis(4-methoxyphenyl)phenylmethoxy]propyl 2-cyanoethyl ester; (2S)-2-[[2-[6-(Benzoylamino)-9H-purin-9-yl]acetyl]amino]-3-[bis(4-methoxyphenyl)phenylmethoxy]propyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite; (S)-SNA-A(Bz) Phosphoramidite

SNA G(iBu) amidite

Description: SNA G(iBu) amidite is a reagent utilized in solid-phase oligonucleotide synthesis, particularly for the synthesis of SNA (serinol nucleic acid) oligomers. It contains guanosine (G) with an isobutyl (iBu) protecting group attached, enabling controlled coupling reactions during synthesis. This reagent is essential for the synthesis of SNA oligonucleotides, which are nucleic acid analogs with modified backbone structures. SNA oligomers have diverse applications in biotechnology, diagnostics, and therapeutics due to their unique properties and potential functionalities.

CAT: BRP-00953

CAS: 1280548-97-1

MF: C44H55N8O8P

MF: 854.95

Purity: >98%

Appearance: Off-white solid

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InChIKey: GIZOJVPZHAXHBF-VJZXMLMYSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: N#CCCOP(OCC(NC(=O)CN1C=NC=2C(=O)N=C(NC(=O)C(C)C)NC21)COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)N(C(C)C)C(C)C

IUPAC Name: (S)-3-(bis(4-methoxyphenyl)(phenyl)methoxy)-2-(2-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)acetamido)propyl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C44H55N8O8P/c1-29(2)41(54)49-43-48-40-39(42(55)50-43)46-28-51(40)25-38(53)47-35(27-60-61(59-24-12-23-45)52(30(3)4)31(5)6)26-58-44(32-13-10-9-11-14-32,33-15-19-36(56-7)20-16-33)34-17-21-37(57-8)22-18-34/h9-11,13-22,28-31,35H,12,24-27H2,1-8H3,(H,47,53)(H2,48,49,50,54,55)/t35-,61?/m0/s1

Synonyms: Phosphoramidous acid, N,N-bis(1-methylethyl)-, (2S)-3-[bis(4-methoxyphenyl)phenylmethoxy]-2-[[2-[1,6-dihydro-2-[(2-methyl-1-oxopropyl)amino]-6-oxo-9H-purin-9-yl]acetyl]amino]propyl 2-cyanoethyl ester; (2S)-3-[Bis(4-methoxyphenyl)phenylmethoxy]-2-[[2-[1,6-dihydro-2-[(2-methyl-1-oxopropyl)amino]-6-oxo-9H-purin-9-yl]acetyl]amino]propyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite; (S)-SNA-G(iBu) Phosphoramidite

DMTr PEG4 amidite

Description: DMTr PEG4 amidite is a reagent used in solid-phase oligonucleotide synthesis, where DMTr stands for 4,4'-dimethoxytrityl protecting group, and PEG4 refers to a tetraethylene glycol (PEG) spacer with four ethylene glycol units. This reagent allows for the controlled synthesis of oligonucleotides with a PEG4 spacer attached. PEGylation can impart various properties to oligonucleotides, such as increased solubility, stability, and reduced nonspecific binding, making them useful in applications like drug delivery, diagnostics, and bioconjugation.

CAT: BRP-00954

CAS: 158041-83-9

MF: C38H53N2O8P

MF: 696.82

Purity: >95%

Appearance: Light-yellow oily matter

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InChIKey: VLNPELUWVKFPRH-UHFFFAOYSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OCCOCCOCCOCCOC(C1=CC=CC=C1)(C2=CC=C(C=C2)OC)C3=CC=C(C=C3)OC

IUPAC Name: 3-[2-[2-[2-[2-[bis(4-methoxyphenyl)-phenylmethoxy]ethoxy]ethoxy]ethoxy]ethoxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C38H53N2O8P/c1-31(2)40(32(3)4)49(47-22-10-21-39)48-30-28-45-26-24-43-23-25-44-27-29-46-38(33-11-8-7-9-12-33,34-13-17-36(41-5)18-14-34)35-15-19-37(42-6)20-16-35/h7-9,11-20,31-32H,10,22-30H2,1-6H3

Synonyms: Phosphoramidous acid, N,N-bis(1-methylethyl)-, 13,13-bis(4-methoxyphenyl)-13-phenyl-3,6,9,12-tetraoxatridec-1-yl 2-cyanoethyl ester; 13,13-Bis(4-methoxyphenyl)-13-phenyl-3,6,9,12-tetraoxatridec-1-yl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, 13,13-bis(4-methoxyphenyl)-13-phenyl-3,6,9,12-tetraoxatridec-1-yl 2-cyanoethyl ester; 1,1-bis(4-methoxyphenyl)-1-phenyl-2,5,8,11-tetraoxatridecan-13-yl (2-cyanoethyl) diisopropylphosphoramidite; DMT-tetraethyloxy-Glycol CED phosphoramidite

1-DMTr-(S)-2-C9-Glycol amidite

Description: 1-DMTr-(S)-2-C9-Glycol amidite is a reagent used in solid-phase oligonucleotide synthesis. This reagent allows for the introduction of a chiral C9 spacer with a glycol moiety into oligonucleotides during synthesis. Chiral spacers can be useful for various applications, such as enhancing binding affinity or specificity in certain contexts.

CAT: BRP-00955

MF: C41H59N2O5P

MF: 690.91

Purity: >95%

Appearance: Light-yellow oily matter

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InChIKey: VDNAYUVRQSPTOJ-VFNQWJAUSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: N#CCCOP(OC(COC(C=1C=CC=CC1)(C2=CC=C(OC)C=C2)C3=CC=C(OC)C=C3)CCCCCCCCC)N(C(C)C)C(C)C

IUPAC Name: 3-[[(2S)-1-[bis(4-methoxyphenyl)-phenylmethoxy]undecan-2-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C41H59N2O5P/c1-8-9-10-11-12-13-17-21-40(48-49(47-31-18-30-42)43(33(2)3)34(4)5)32-46-41(35-19-15-14-16-20-35,36-22-26-38(44-6)27-23-36)37-24-28-39(45-7)29-25-37/h14-16,19-20,22-29,33-34,40H,8-13,17-18,21,31-32H2,1-7H3/t40-,49?/m0/s1

Synonyms: Phosphoramidous acid, bis(1-methylethyl)-, 1-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]decyl 2-cyanoethyl ester, (1S)-; (S)-1-(bis(4-methoxyphenyl)(phenyl)methoxy)undecan-2-yl (2-cyanoethyl) diisopropylphosphoramidite

Related CAS: 178939-65-6 (R-isomer)

1-DMTr-2-(S)-propanediyl amidite

Description: 1-DMTr-2-(S)-propanediyl amidite is a reagent used in solid-phase oligonucleotide synthesis. This reagent allows for the introduction of a chiral propanediyl spacer into oligonucleotides during synthesis. Chiral spacers can impart specific properties or functionalities to oligonucleotides, making them useful for various applications in biotechnology and therapeutics.

CAT: BRP-00956

CAS: 161029-25-0

MF: C33H43N2O5P

MF: 578.69

Purity: >95%

Appearance: Light-yellow oily matter

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InChIKey: XCLJWHBPKOARSH-VNFCCXQASA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: N#CCCOP(OC(C)COC(C=1C=CC=CC1)(C2=CC=C(OC)C=C2)C3=CC=C(OC)C=C3)N(C(C)C)C(C)C

IUPAC Name: (S)-1-(bis(4-methoxyphenyl)(phenyl)methoxy)propan-2-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C33H43N2O5P/c1-25(2)35(26(3)4)41(39-23-11-22-34)40-27(5)24-38-33(28-12-9-8-10-13-28,29-14-18-31(36-6)19-15-29)30-16-20-32(37-7)21-17-30/h8-10,12-21,25-27H,11,23-24H2,1-7H3/t27-,41?/m0/s1

Synonyms: Phosphoramidous acid, bis(1-methylethyl)-, 2-[bis(4-methoxyphenyl)phenylmethoxy]-1-methylethyl 2-cyanoethyl ester, (1S)-

1-DMTr-3-(S)-butanediyl amidite

Description: 1-DMTr-3-(S)-butanediyl amidite is a reagent used in solid-phase oligonucleotide synthesis. This reagent allows for the introduction of a chiral butanediyl spacer into oligonucleotides during synthesis. Chiral spacers can introduce specific properties or functionalities to oligonucleotides, useful for various applications in biotechnology and therapeutics.

CAT: BRP-00957

CAS: 161106-24-7

MF: C34H45N2O5P

MF: 592.72

Purity: >95%

Appearance: Light-yellow oily matter

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InChIKey: QTYXEIMXWNEEOP-DHZXTJRXSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: N#CCCOP(OC(C)CCOC(C=1C=CC=CC1)(C2=CC=C(OC)C=C2)C3=CC=C(OC)C=C3)N(C(C)C)C(C)C

IUPAC Name: 3-[[(2S)-4-[bis(4-methoxyphenyl)-phenylmethoxy]butan-2-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C34H45N2O5P/c1-26(2)36(27(3)4)42(40-24-11-23-35)41-28(5)22-25-39-34(29-12-9-8-10-13-29,30-14-18-32(37-6)19-15-30)31-16-20-33(38-7)21-17-31/h8-10,12-21,26-28H,11,22,24-25H2,1-7H3/t28-,42?/m0/s1

Synonyms: Phosphoramidous acid, bis(1-methylethyl)-, (1S)-3-[bis(4-methoxyphenyl)phenylmethoxy]-1-methylpropyl 2-cyanoethyl ester; Phosphoramidous acid, bis(1-methylethyl)-, 3-[bis(4-methoxyphenyl)phenylmethoxy]-1-methylpropyl 2-cyanoethyl ester, (1S)-; (S)-4-(bis(4-methoxyphenyl)(phenyl)methoxy)butan-2-yl (2-cyanoethyl) diisopropylphosphoramidite

Propargyl C4 amidite

Description: Propargyl C4 amidite is a reagent used in oligonucleotide synthesis. This reagent allows for the introduction of a propargyl modification of the nucleobase during oligonucleotide synthesis. Propargyl modifications are useful for various applications such as click chemistry reactions for further functionalization or conjugation.

CAT: BRP-00958

CAS: 1173382-08-5

MF: C16H29N2O3P

MF: 328.39

Purity: >95%

Appearance: Light-yellow oily matter

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InChIKey: LQEYCRIHZDOGRQ-UHFFFAOYSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: N#CCCOP(OCCCCOCC#C)N(C(C)C)C(C)C

IUPAC Name: 2-cyanoethyl (4-(prop-2-yn-1-yloxy)butyl) diisopropylphosphoramidite

InChI: InChI=1S/C16H29N2O3P/c1-6-11-19-12-7-8-13-20-22(21-14-9-10-17)18(15(2)3)16(4)5/h1,15-16H,7-9,11-14H2,2-5H3

Synonyms: Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl 4-(2-propyn-1-yloxy)butyl ester; 2-Cyanoethyl 4-(2-propyn-1-yloxy)butyl N,N-bis(1-methylethyl)phosphoramidite