Phosphoramidites

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2'-Modified Phosphoramidites
(466/466) 2'-Phosphoramidites
(21/21) 3'-Modified Phosphoramidites
(186/186) 5'-Modified Phosphoramidites
(21/21) Arabino Phosphoramidites
(19/19) Base Protected Phosphoramidites (365/365) Dye Phosphoramidites
(53/53) Label Phosphoramidites
(82/82) Linker Phosphoramidites
(72/72) Other Phosphoramidites
(92/92) PMO Phosphoramidates and Derivatives (33/33) PseudoUridine Phosphoramidite
(12/12) Reverse Phosphoramidites
(15/15) Spacer Phosphoramidites
(22/22)
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2'-OMe G(iBu) (TBSO)SATE-amidite

Description: 2'-OMe G(iBu) (TBSO)SATE-amidite is a reagent used in oligonucleotide synthesis. It contains a methyl (Me) group at the 2' position of ribose, guanosine (G) potentially protected with an isobutyl (iBu) group. This reagent enables the controlled synthesis of modified oligonucleotides with enhanced stability and specific functionalities.
CAT: BRP-00939
MF: C55H79N6O11PSSi
MF: 1091.40
Purity: >95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: KNYQSRGOAUUKQY-HYFQDGRXSA-N
Solubility: Soluble in Acetonitrile, DMF
IUPAC Name: S-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethyl) 3-((tert-butyldimethylsilyl)oxy)-2,2-dimethylpropanethioate
InChI: InChI=1S/C55H79N6O11PSSi/c1-35(2)48(62)58-52-57-47-44(49(63)59-52)56-34-60(47)50-46(67-14)45(72-73(61(36(3)4)37(5)6)69-30-31-74-51(64)54(10,11)33-70-75(15,16)53(7,8)9)43(71-50)32-68-55(38-20-18-17-19-21-38,39-22-26-41(65-12)27-23-39)40-24-28-42(66-13)29-25-40/h17-29,34-37,43,45-46,50H,30-33H2,1-16H3,(H2,57,58,59,62,63)/t43-,45-,46-,50-,73?/m1/s1

2'-OMe A(Bz) (TBSO)SATE-amidite

Description: 2'-OMe A(Bz) (TBSO)SATE-amidite is a reagent utilized in oligonucleotide synthesis. It contains a methyl (Me) group at the 2' position of ribose, adenine (A) potentially protected with a benzoyl (Bz) group. This reagent enables the controlled synthesis of modified oligonucleotides with improved stability and specific functionalities.
CAT: BRP-00940
MF: C58H77N6O10PSSi
MF: 1109.41
Purity: >95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: BPRJNTIBJAXHFE-SLDILDNQSA-N
Solubility: Soluble in Acetonitrile, DMF
IUPAC Name: S-(2-(((((2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethyl) 3-((tert-butyldimethylsilyl)oxy)-2,2-dimethylpropanethioate
InChI: InChI=1S/C58H77N6O10PSSi/c1-39(2)64(40(3)4)75(71-33-34-76-55(66)57(8,9)36-72-77(13,14)56(5,6)7)74-49-47(73-54(50(49)69-12)63-38-61-48-51(59-37-60-52(48)63)62-53(65)41-21-17-15-18-22-41)35-70-58(42-23-19-16-20-24-42,43-25-29-45(67-10)30-26-43)44-27-31-46(68-11)32-28-44/h15-32,37-40,47,49-50,54H,33-36H2,1-14H3,(H,59,60,62,65)/t47-,49-,50-,54-,75?/m1/s1

2'-OMe C(Bz) (TBSO)SATE-amidite

Description: 2'-OMe C(Bz) (TBSO)SATE-amidite is a reagent used in oligonucleotide synthesis. It contains a methyl (Me) group at the 2' position of ribose, cytosine (C) potentially protected with a benzoyl (Bz) group. This reagent facilitates the controlled synthesis of modified oligonucleotides with enhanced stability and specific functionalities.
CAT: BRP-00941
MF: C57H77N4O11PSSi
MF: 1085.39
Purity: >95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: IGTHQWLLAPOEKK-LEOYGVFQSA-N
Solubility: Soluble in Acetonitrile, DMF
IUPAC Name: S-(2-(((((2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethyl) 3-((tert-butyldimethylsilyl)oxy)-2,2-dimethylpropanethioate
InChI: InChI=1S/C57H77N4O11PSSi/c1-39(2)61(40(3)4)73(69-35-36-74-53(63)56(8,9)38-70-75(13,14)55(5,6)7)72-49-47(71-52(50(49)67-12)60-34-33-48(59-54(60)64)58-51(62)41-21-17-15-18-22-41)37-68-57(42-23-19-16-20-24-42,43-25-29-45(65-10)30-26-43)44-27-31-46(66-11)32-28-44/h15-34,39-40,47,49-50,52H,35-38H2,1-14H3,(H,58,59,62,64)/t47-,49-,50-,52-,73?/m1/s1

2'-OMe U (TBSO)SATE-amidite

Description: 2'-OMe U (TBSO)SATE-amidite is a reagent utilized in oligonucleotide synthesis. It contains a methyl (Me) group at the 2' position of ribose and incorporates uracil (U). This reagent facilitates the controlled synthesis of modified oligonucleotides with enhanced stability and specific functionalities, possibly through the introduction of protecting groups or linkers.
CAT: BRP-00942
MF: C50H72N3O11PSSi
MF: 982.26
Purity: >95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: JPIPEHQBJWFYBS-DLBBVOJMSA-N
Solubility: Soluble in Acetonitrile, DMF
IUPAC Name: S-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethyl) 3-((tert-butyldimethylsilyl)oxy)-2,2-dimethylpropanethioate
InChI: InChI=1S/C50H72N3O11PSSi/c1-34(2)53(35(3)4)65(61-30-31-66-46(55)49(8,9)33-62-67(13,14)48(5,6)7)64-43-41(63-45(44(43)59-12)52-29-28-42(54)51-47(52)56)32-60-50(36-18-16-15-17-19-36,37-20-24-39(57-10)25-21-37)38-22-26-40(58-11)27-23-38/h15-29,34-35,41,43-45H,30-33H2,1-14H3,(H,51,54,56)/t41-,43-,44-,45-,65?/m1/s1

2'-OMe U PACE amidite

Description: 2'-OMe U PACE amidite is a reagent employed in oligonucleotide synthesis. It features a methyl (Me) group at the 2' position of ribose and contains uracil (U). ''PACE'' likely refers to a specific modification or functional group incorporated into the nucleotide. This reagent facilitates the controlled synthesis of modified oligonucleotides with specific properties or functionalities, although the exact nature of ''PACE'' would determine its specific role in the synthesis process.
CAT: BRP-00943
CAS: 411234-28-1
MF: C44H55N4O10P
MF: 830.92
Purity: >98%
Appearance: White to off-white powder
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Storage: Store at -20 °C
InChIKey: KZVIZOJLWDQWHO-VJPJVJEPSA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: CC(C)N(C(C)C)P(CC(=O)OC(C)(C)CC#N)OC1C(OC(C1OC)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC
IUPAC Name: (1-cyano-2-methylpropan-2-yl) 2-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(2,4-dioxopyrimidin-1-yl)-4-methoxyoxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]acetate
InChI: InChI=1S/C44H55N4O10P/c1-29(2)48(30(3)4)59(28-38(50)57-43(5,6)24-25-45)58-39-36(56-41(40(39)54-9)47-26-23-37(49)46-42(47)51)27-55-44(31-13-11-10-12-14-31,32-15-19-34(52-7)20-16-32)33-17-21-35(53-8)22-18-33/h10-23,26,29-30,36,39-41H,24,27-28H2,1-9H3,(H,46,49,51)/t36-,39-,40-,41-,59?/m1/s1
Synonyms: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[P-[2-(2-cyano-1,1-dimethylethoxy)-2-oxoethyl]-N,N-bis(1-methylethyl)phosphonamidite]; 1-cyano-2-methylpropan-2-yl 2-((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)acetate; 5'-O-DMTr-2'-O-Me-U PACE; 3'-O-(Diisopropylamino)phosphinoacetic acid α,α-dimethyl-β-cyanoethyl methyl ester 5'-O-(4,4'-dimethoxytrityl)-2'-O-methyluridine

2'-OMe C(Ac) PACE amidite

Description: 2'-OMe C(Ac) PACE amidite is a reagent used in oligonucleotide synthesis. It contains a methyl (Me) group at the 2' position of ribose, cytosine (C) potentially protected with an acetyl (Ac) group, and incorporates a modification referred to as ''PACE''. This modification might introduce specific functionalities or properties to the oligonucleotide. The exact nature of ''PACE'' would determine its role in the synthesis process and the properties of the resulting oligonucleotide.
CAT: BRP-00944
CAS: 1355047-25-4
MF: C46H58N5O10P
MF: 871.97
Purity: >98%
Appearance: White solid
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Storage: Store at -20 °C
InChIKey: RQLMSVYEXLXTTN-YQKQXIHOSA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: CC(C)N(C(C)C)P(CC(=O)OC(C)(C)CC#N)OC1C(OC(C1OC)N2C=CC(=NC2=O)NC(=O)C)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC
IUPAC Name: (1-cyano-2-methylpropan-2-yl) 2-[[(2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1-yl)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-methoxyoxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]acetate
InChI: InChI=1S/C46H58N5O10P/c1-30(2)51(31(3)4)62(29-40(53)60-45(6,7)25-26-47)61-41-38(59-43(42(41)57-10)50-27-24-39(48-32(5)52)49-44(50)54)28-58-46(33-14-12-11-13-15-33,34-16-20-36(55-8)21-17-34)35-18-22-37(56-9)23-19-35/h11-24,27,30-31,38,41-43H,25,28-29H2,1-10H3,(H,48,49,52,54)/t38-,41-,42-,43-,62?/m1/s1
Synonyms: Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[P-[2-(2-cyano-1,1-dimethylethoxy)-2-oxoethyl]-N,N-bis(1-methylethyl)phosphonamidite]; 1-cyano-2-methylpropan-2-yl 2-((((2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)acetate; 5'-O-DMTr-2'-O-Me-C(Ac) PACE; 3'-O-(Diisopropylamino)phosphinoacetic acid α,α-dimethyl-β-cyanoethyl methyl ester N4-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methylcytidine

2'-OMe A(Bz) PACE amidite

Description: 2'-OMe A(Bz) PACE amidite is a reagent utilized in oligonucleotide synthesis. It contains a methyl (Me) group at the 2' position of ribose, adenine (A) potentially protected with a benzoyl (Bz) group, and incorporates a modification known as ''PACE''. This modification introduces specific functionalities or properties to the oligonucleotide. The exact nature of ''PACE'' would dictate its role in the synthesis process and the characteristics of the resulting oligonucleotide.
CAT: BRP-00945
CAS: 1355047-24-3
MF: C52H60N7O9P
MF: 958.07
Purity: >97%
Appearance: White solid
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Storage: Store at -20 °C
InChIKey: JWEJRQXHPXDTPT-GCZIAXJXSA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: CC(C)N(C(C)C)P(CC(=O)OC(C)(C)CC#N)OC1C(OC(C1OC)N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC
IUPAC Name: (1-cyano-2-methylpropan-2-yl) 2-[[(2R,3R,4R,5R)-5-(6-benzamidopurin-9-yl)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-methoxyoxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]acetate
InChI: InChI=1S/C52H60N7O9P/c1-34(2)59(35(3)4)69(31-43(60)67-51(5,6)28-29-53)68-45-42(66-50(46(45)64-9)58-33-56-44-47(54-32-55-48(44)58)57-49(61)36-16-12-10-13-17-36)30-65-52(37-18-14-11-15-19-37,38-20-24-40(62-7)25-21-38)39-22-26-41(63-8)27-23-39/h10-27,32-35,42,45-46,50H,28,30-31H2,1-9H3,(H,54,55,57,61)/t42-,45-,46-,50-,69?/m1/s1
Synonyms: Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[P-[2-(2-cyano-1,1-dimethylethoxy)-2-oxoethyl]-N,N-bis(1-methylethyl)phosphonamidite]; 1-cyano-2-methylpropan-2-yl 2-((((2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)acetate

2'-OMe G(iBu) PACE amidite

Description: 2'-OMe G(iBu) PACE amidite is a reagent used in oligonucleotide synthesis. It contains a methyl (Me) group at the 2' position of ribose, guanosine (G) potentially protected with an isobutyl (iBu) group, and incorporates a modification referred to as ''PACE''. This modification introduces specific functionalities or properties to the oligonucleotide. The exact nature of ''PACE'' would determine its role in the synthesis process and the characteristics of the resulting oligonucleotide.
CAT: BRP-00946
CAS: 1355047-26-5
MF: C49H62N7O10P
MF: 940.05
Purity: >98%
Appearance: White solid
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Storage: Store at -20 °C
InChIKey: IEFSKQYVGBGNHJ-GGUIJGGTSA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(CC(=O)OC(C)(C)CC#N)N(C(C)C)C(C)C)OC
IUPAC Name: (1-cyano-2-methylpropan-2-yl) 2-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-methoxy-5-[2-(2-methylpropanoylamino)-6-oxo-1H-purin-9-yl]oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]acetate
InChI: InChI=1S/C49H62N7O10P/c1-30(2)44(58)53-47-52-43-40(45(59)54-47)51-29-55(43)46-42(62-11)41(66-67(56(31(3)4)32(5)6)28-39(57)65-48(7,8)25-26-50)38(64-46)27-63-49(33-15-13-12-14-16-33,34-17-21-36(60-9)22-18-34)35-19-23-37(61-10)24-20-35/h12-24,29-32,38,41-42,46H,25,27-28H2,1-11H3,(H2,52,53,54,58,59)/t38-,41-,42-,46-,67?/m1/s1
Synonyms: Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-N-(2-methyl-1-oxopropyl)-, 3'-[P-[2-(2-cyano-1,1-dimethylethoxy)-2-oxoethyl]-N,N-bis(1-methylethyl)phosphonamidite]; 1-cyano-2-methylpropan-2-yl 2-((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)acetate

2'-OTBS U ThioPhosphamidite

Description: 2'-OTBS U ThioPhosphamidite is a reagent used in oligonucleotide synthesis. It contains a tert-butyldimethylsilyl (TBS) protecting group at the 2' position of ribose, uracil (U), and incorporates a thio modification. ThioPhosphamidite suggests the presence of a phosphoramidite moiety with a thiol (-SH) group attached. This reagent allows for the controlled synthesis of oligonucleotides with thio modifications, which can impart specific chemical or biological properties to the resulting oligonucleotide sequences.
CAT: BRP-00947
CAS: 1374755-68-6
MF: C49H60N3O9PS2Si
MF: 958.23
Purity: >98%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: CSXWIDBTNRBSQY-CRHOWCKESA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: CC(C)(C)[Si](C)(C)OC1C(C(OC1N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OP(N6CCCC6)SCCSC(=O)C7=CC=CC=C7
IUPAC Name: S-[2-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-5-(2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-pyrrolidin-1-ylphosphanyl]sulfanylethyl] benzenecarbothioate
InChI: InChI=1S/C49H60N3O9PS2Si/c1-48(2,3)65(6,7)61-44-43(60-62(51-29-14-15-30-51)64-33-32-63-46(54)35-16-10-8-11-17-35)41(59-45(44)52-31-28-42(53)50-47(52)55)34-58-49(36-18-12-9-13-19-36,37-20-24-39(56-4)25-21-37)38-22-26-40(57-5)27-23-38/h8-13,16-28,31,41,43-45H,14-15,29-30,32-34H2,1-7H3,(H,50,53,55)/t41-,43-,44-,45-,62?/m1/s1
Synonyms: 5'-DMT-2'-OTBS-U-3'-PS-Phosphoramidite; DMT-2'-OTBS-U-3'-PS; S-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)oxy)(pyrrolidin-1-yl)phosphaneyl)thio)ethyl) benzothioate; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-[S-[2-(benzoylthio)ethyl] P-1-pyrrolidinylphosphonothioite]

2'-OTBS A(Bz) ThioPhosphamidite

Description: 2'-OTBS A(Bz) ThioPhosphamidite is a reagent used in oligonucleotide synthesis. It contains a tert-butyldimethylsilyl (TBS) protecting group at the 2' position of ribose, adenine (A) potentially protected with a benzoyl (Bz) group, and incorporates a thio modification. ThioPhosphamidite suggests the presence of a phosphoramidite moiety with a thiol (-SH) group attached. This reagent enables the controlled synthesis of oligonucleotides with thio modifications, offering specific chemical or biological functionalities to the resulting sequences.
CAT: BRP-00948
CAS: 1374755-65-3
MF: C57H65N6O8PS2Si
MF: 1085.38
Purity: >95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: ALJIYXCITZABFP-WOMFGPHHSA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: CC(C)(C)[Si](C)(C)OC1C(C(OC1N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC)OP(N8CCCC8)SCCSC(=O)C9=CC=CC=C9
IUPAC Name: S-[2-[[(2R,3R,4R,5R)-5-(6-benzamidopurin-9-yl)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxyoxolan-3-yl]oxy-pyrrolidin-1-ylphosphanyl]sulfanylethyl] benzenecarbothioate
InChI: InChI=1S/C57H65N6O8PS2Si/c1-56(2,3)75(6,7)71-50-49(70-72(62-33-17-18-34-62)74-36-35-73-55(65)41-21-13-9-14-22-41)47(69-54(50)63-39-60-48-51(58-38-59-52(48)63)61-53(64)40-19-11-8-12-20-40)37-68-57(42-23-15-10-16-24-42,43-25-29-45(66-4)30-26-43)44-27-31-46(67-5)32-28-44/h8-16,19-32,38-39,47,49-50,54H,17-18,33-37H2,1-7H3,(H,58,59,61,64)/t47-,49-,50-,54-,72?/m1/s1
Synonyms: 5'-DMT-2'-OTBS-A(Bz)-3'-PS-Phosphoramidite; S-(2-(((((2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl)oxy)(pyrrolidin-1-yl)phosphaneyl)thio)ethyl) benzothioate; Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-[S-[2-(benzoylthio)ethyl] P-1-pyrrolidinylphosphonothioite]; DMT-2'-OTBS-A(Bz)-3'-PS

2'-OTBS C(Ac) ThioPhosphamidite

Description: 2'-OTBS C(Ac) ThioPhosphamidite is a reagent used in oligonucleotide synthesis. It contains a tert-butyldimethylsilyl (TBS) protecting group at the 2' position of ribose, cytosine (C) potentially protected with an acetyl (Ac) group, and incorporates a thio modification. ThioPhosphamidite suggests the presence of a phosphoramidite moiety with a thiol (-SH) group attached. This reagent facilitates the controlled synthesis of oligonucleotides with thio modifications, providing specific chemical or biological functionalities to the resulting sequences.
CAT: BRP-00949
CAS: 1374755-66-4
MF: C51H63N4O9PS2Si
MF: 999.28
Purity: >98%
Appearance: Off-white solid
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InChIKey: KEDMUXPEKPOPCR-YTFDKTRSSA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: CC(=O)NC1=NC(=O)N(C=C1)C2C(C(C(O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OP(N6CCCC6)SCCSC(=O)C7=CC=CC=C7)O[Si](C)(C)C(C)(C)C
IUPAC Name: S-[2-[[(2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1-yl)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxyoxolan-3-yl]oxy-pyrrolidin-1-ylphosphanyl]sulfanylethyl] benzenecarbothioate
InChI: InChI=1S/C51H63N4O9PS2Si/c1-36(56)52-44-29-32-55(49(58)53-44)47-46(64-68(7,8)50(2,3)4)45(63-65(54-30-15-16-31-54)67-34-33-66-48(57)37-17-11-9-12-18-37)43(62-47)35-61-51(38-19-13-10-14-20-38,39-21-25-41(59-5)26-22-39)40-23-27-42(60-6)28-24-40/h9-14,17-29,32,43,45-47H,15-16,30-31,33-35H2,1-8H3,(H,52,53,56,58)/t43-,45-,46-,47-,65?/m1/s1
Synonyms: 5'-DMT-2'-OTBS-C(Ac)-3'-PS-Phosphoramidite; DMT-2'-OTBS-C(Ac)-3'-PS; Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-[S-[2-(benzoylthio)ethyl] P-1-pyrrolidinylphosphonothioite]; S-(2-(((((2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl)oxy)(pyrrolidin-1-yl)phosphaneyl)thio)ethyl) benzothioate

2'-OTBS G(iBu) ThioPhosphamidite

Description: 2'-OTBS G(iBu) ThioPhosphamidite is a reagent used in oligonucleotide synthesis. It contains a tert-butyldimethylsilyl (TBS) protecting group at the 2' position of ribose, guanosine (G) potentially protected with an isobutyl (iBu) group, and incorporates a thio modification. ThioPhosphamidite suggests the presence of a phosphoramidite moiety with a thiol (-SH) group attached. This reagent enables the controlled synthesis of oligonucleotides with thio modifications, providing specific chemical or biological functionalities to the resulting sequences.
CAT: BRP-00950
MF: C54H67N6O9PS2Si
MF: 1067.36
Purity: >95%
Appearance: Off-white solid
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InChIKey: HXMLZPZNEIUXMQ-UFCBNZGASA-N
Solubility: Soluble in Acetonitrile, DMF
IUPAC Name: S-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl)oxy)(pyrrolidin-1-yl)phosphaneyl)thio)ethyl) benzothioate
InChI: InChI=1S/C54H67N6O9PS2Si/c1-36(2)48(61)57-52-56-47-44(49(62)58-52)55-35-60(47)50-46(69-73(8,9)53(3,4)5)45(68-70(59-30-16-17-31-59)72-33-32-71-51(63)37-18-12-10-13-19-37)43(67-50)34-66-54(38-20-14-11-15-21-38,39-22-26-41(64-6)27-23-39)40-24-28-42(65-7)29-25-40/h10-15,18-29,35-36,43,45-46,50H,16-17,30-34H2,1-9H3,(H2,56,57,58,61,62)/t43-,45-,46-,50-,70?/m1/s1
Synonyms: 5'-DMT-2'-OTBS-G(iBu)-3'-PS-Phosphoramidite; DMT-2'-OTBS-G(iBu)-3'-PS

SNA C(Bz) amidite

Description: SNA C(Bz) amidite is a reagent used in solid-phase oligonucleotide synthesis, particularly in the synthesis of SNA (serinol nucleic acid) oligomers. It contains cytosine (C) with a benzoyl (Bz) protecting group attached to the amino group of the nucleobase, allowing for controlled coupling reactions during synthesis. SNA, or serinol nucleic acid, is a type of nucleic acid analog. This reagent facilitates the synthesis of SNA oligonucleotides, which have applications in various biotechnological and therapeutic areas due to their unique properties.
CAT: BRP-00951
CAS: 1280548-93-7
MF: C46H53N6O8P
MF: 848.94
Purity: >98%
Appearance: Off-white solid
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InChIKey: XRUGORVLABOZAD-PPCUMKKXSA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: N#CCCOP(OCC(NC(=O)CN1C=CC(=NC1=O)NC(=O)C=2C=CC=CC2)COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)N(C(C)C)C(C)C
IUPAC Name: (S)-2-(2-(4-benzamido-2-oxopyrimidin-1(2H)-yl)acetamido)-3-(bis(4-methoxyphenyl)(phenyl)methoxy)propyl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C46H53N6O8P/c1-33(2)52(34(3)4)61(59-29-13-27-47)60-32-39(48-43(53)30-51-28-26-42(50-45(51)55)49-44(54)35-14-9-7-10-15-35)31-58-46(36-16-11-8-12-17-36,37-18-22-40(56-5)23-19-37)38-20-24-41(57-6)25-21-38/h7-12,14-26,28,33-34,39H,13,29-32H2,1-6H3,(H,48,53)(H,49,50,54,55)/t39-,61?/m0/s1
Synonyms: Phosphoramidous acid, N,N-bis(1-methylethyl)-, (2S)-2-[[2-[4-(benzoylamino)-2-oxo-1(2H)-pyrimidinyl]acetyl]amino]-3-[bis(4-methoxyphenyl)phenylmethoxy]propyl 2-cyanoethyl ester; (2S)-2-[[2-[4-(Benzoylamino)-2-oxo-1(2H)-pyrimidinyl]acetyl]amino]-3-[bis(4-methoxyphenyl)phenylmethoxy]propyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite; (S)-SNA-C(Bz) Phosphoramidite

SNA A(Bz) amidite

Description: SNA A(Bz) amidite is a reagent used in solid-phase oligonucleotide synthesis, particularly for synthesizing SNA (serinol nucleic acid) oligomers. It contains adenine (A) with a benzoyl (Bz) protecting group attached to the amino group of the nucleobase, enabling controlled coupling reactions during synthesis. This reagent facilitates the synthesis of SNA oligonucleotides, which are nucleic acid analogs with modified backbone structures. SNA oligomers have applications in various fields such as molecular biology, diagnostics, and therapeutics due to their unique properties and potential functionalities.
CAT: BRP-00952
CAS: 1280548-94-8
MF: C47H53N8O7P
MF: 872.96
Purity: >97%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: ALIIACZLWAKPSI-QGGVFJROSA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: N#CCCOP(OCC(NC(=O)CN1C=NC=2C(=NC=NC21)NC(=O)C=3C=CC=CC3)COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C
IUPAC Name: (S)-2-(2-(6-benzamido-9H-purin-9-yl)acetamido)-3-(bis(4-methoxyphenyl)(phenyl)methoxy)propyl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C47H53N8O7P/c1-33(2)55(34(3)4)63(61-27-13-26-48)62-30-39(52-42(56)28-54-32-51-43-44(49-31-50-45(43)54)53-46(57)35-14-9-7-10-15-35)29-60-47(36-16-11-8-12-17-36,37-18-22-40(58-5)23-19-37)38-20-24-41(59-6)25-21-38/h7-12,14-25,31-34,39H,13,27-30H2,1-6H3,(H,52,56)(H,49,50,53,57)/t39-,63?/m0/s1
Synonyms: Phosphoramidous acid, N,N-bis(1-methylethyl)-, (2S)-2-[[2-[6-(benzoylamino)-9H-purin-9-yl]acetyl]amino]-3-[bis(4-methoxyphenyl)phenylmethoxy]propyl 2-cyanoethyl ester; (2S)-2-[[2-[6-(Benzoylamino)-9H-purin-9-yl]acetyl]amino]-3-[bis(4-methoxyphenyl)phenylmethoxy]propyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite; (S)-SNA-A(Bz) Phosphoramidite

SNA G(iBu) amidite

Description: SNA G(iBu) amidite is a reagent utilized in solid-phase oligonucleotide synthesis, particularly for the synthesis of SNA (serinol nucleic acid) oligomers. It contains guanosine (G) with an isobutyl (iBu) protecting group attached, enabling controlled coupling reactions during synthesis. This reagent is essential for the synthesis of SNA oligonucleotides, which are nucleic acid analogs with modified backbone structures. SNA oligomers have diverse applications in biotechnology, diagnostics, and therapeutics due to their unique properties and potential functionalities.
CAT: BRP-00953
CAS: 1280548-97-1
MF: C44H55N8O8P
MF: 854.95
Purity: >98%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: GIZOJVPZHAXHBF-VJZXMLMYSA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: N#CCCOP(OCC(NC(=O)CN1C=NC=2C(=O)N=C(NC(=O)C(C)C)NC21)COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)N(C(C)C)C(C)C
IUPAC Name: (S)-3-(bis(4-methoxyphenyl)(phenyl)methoxy)-2-(2-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)acetamido)propyl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C44H55N8O8P/c1-29(2)41(54)49-43-48-40-39(42(55)50-43)46-28-51(40)25-38(53)47-35(27-60-61(59-24-12-23-45)52(30(3)4)31(5)6)26-58-44(32-13-10-9-11-14-32,33-15-19-36(56-7)20-16-33)34-17-21-37(57-8)22-18-34/h9-11,13-22,28-31,35H,12,24-27H2,1-8H3,(H,47,53)(H2,48,49,50,54,55)/t35-,61?/m0/s1
Synonyms: Phosphoramidous acid, N,N-bis(1-methylethyl)-, (2S)-3-[bis(4-methoxyphenyl)phenylmethoxy]-2-[[2-[1,6-dihydro-2-[(2-methyl-1-oxopropyl)amino]-6-oxo-9H-purin-9-yl]acetyl]amino]propyl 2-cyanoethyl ester; (2S)-3-[Bis(4-methoxyphenyl)phenylmethoxy]-2-[[2-[1,6-dihydro-2-[(2-methyl-1-oxopropyl)amino]-6-oxo-9H-purin-9-yl]acetyl]amino]propyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite; (S)-SNA-G(iBu) Phosphoramidite

DMTr PEG4 amidite

Description: DMTr PEG4 amidite is a reagent used in solid-phase oligonucleotide synthesis, where DMTr stands for 4,4'-dimethoxytrityl protecting group, and PEG4 refers to a tetraethylene glycol (PEG) spacer with four ethylene glycol units. This reagent allows for the controlled synthesis of oligonucleotides with a PEG4 spacer attached. PEGylation can impart various properties to oligonucleotides, such as increased solubility, stability, and reduced nonspecific binding, making them useful in applications like drug delivery, diagnostics, and bioconjugation.
CAT: BRP-00954
CAS: 158041-83-9
MF: C38H53N2O8P
MF: 696.82
Purity: >95%
Appearance: Light-yellow oily matter
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InChIKey: VLNPELUWVKFPRH-UHFFFAOYSA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OCCOCCOCCOCCOC(C1=CC=CC=C1)(C2=CC=C(C=C2)OC)C3=CC=C(C=C3)OC
IUPAC Name: 3-[2-[2-[2-[2-[bis(4-methoxyphenyl)-phenylmethoxy]ethoxy]ethoxy]ethoxy]ethoxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
InChI: InChI=1S/C38H53N2O8P/c1-31(2)40(32(3)4)49(47-22-10-21-39)48-30-28-45-26-24-43-23-25-44-27-29-46-38(33-11-8-7-9-12-33,34-13-17-36(41-5)18-14-34)35-15-19-37(42-6)20-16-35/h7-9,11-20,31-32H,10,22-30H2,1-6H3
Synonyms: Phosphoramidous acid, N,N-bis(1-methylethyl)-, 13,13-bis(4-methoxyphenyl)-13-phenyl-3,6,9,12-tetraoxatridec-1-yl 2-cyanoethyl ester; 13,13-Bis(4-methoxyphenyl)-13-phenyl-3,6,9,12-tetraoxatridec-1-yl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, 13,13-bis(4-methoxyphenyl)-13-phenyl-3,6,9,12-tetraoxatridec-1-yl 2-cyanoethyl ester; 1,1-bis(4-methoxyphenyl)-1-phenyl-2,5,8,11-tetraoxatridecan-13-yl (2-cyanoethyl) diisopropylphosphoramidite; DMT-tetraethyloxy-Glycol CED phosphoramidite

1-DMTr-(S)-2-C9-Glycol amidite

Description: 1-DMTr-(S)-2-C9-Glycol amidite is a reagent used in solid-phase oligonucleotide synthesis. This reagent allows for the introduction of a chiral C9 spacer with a glycol moiety into oligonucleotides during synthesis. Chiral spacers can be useful for various applications, such as enhancing binding affinity or specificity in certain contexts.
CAT: BRP-00955
MF: C41H59N2O5P
MF: 690.91
Purity: >95%
Appearance: Light-yellow oily matter
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Storage: Store at -20 °C
InChIKey: VDNAYUVRQSPTOJ-VFNQWJAUSA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: N#CCCOP(OC(COC(C=1C=CC=CC1)(C2=CC=C(OC)C=C2)C3=CC=C(OC)C=C3)CCCCCCCCC)N(C(C)C)C(C)C
IUPAC Name: 3-[[(2S)-1-[bis(4-methoxyphenyl)-phenylmethoxy]undecan-2-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
InChI: InChI=1S/C41H59N2O5P/c1-8-9-10-11-12-13-17-21-40(48-49(47-31-18-30-42)43(33(2)3)34(4)5)32-46-41(35-19-15-14-16-20-35,36-22-26-38(44-6)27-23-36)37-24-28-39(45-7)29-25-37/h14-16,19-20,22-29,33-34,40H,8-13,17-18,21,31-32H2,1-7H3/t40-,49?/m0/s1
Synonyms: Phosphoramidous acid, bis(1-methylethyl)-, 1-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]decyl 2-cyanoethyl ester, (1S)-; (S)-1-(bis(4-methoxyphenyl)(phenyl)methoxy)undecan-2-yl (2-cyanoethyl) diisopropylphosphoramidite
Related CAS: 178939-65-6 (R-isomer)

1-DMTr-2-(S)-propanediyl amidite

Description: 1-DMTr-2-(S)-propanediyl amidite is a reagent used in solid-phase oligonucleotide synthesis. This reagent allows for the introduction of a chiral propanediyl spacer into oligonucleotides during synthesis. Chiral spacers can impart specific properties or functionalities to oligonucleotides, making them useful for various applications in biotechnology and therapeutics.
CAT: BRP-00956
CAS: 161029-25-0
MF: C33H43N2O5P
MF: 578.69
Purity: >95%
Appearance: Light-yellow oily matter
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Storage: Store at -20 °C
InChIKey: XCLJWHBPKOARSH-VNFCCXQASA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: N#CCCOP(OC(C)COC(C=1C=CC=CC1)(C2=CC=C(OC)C=C2)C3=CC=C(OC)C=C3)N(C(C)C)C(C)C
IUPAC Name: (S)-1-(bis(4-methoxyphenyl)(phenyl)methoxy)propan-2-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C33H43N2O5P/c1-25(2)35(26(3)4)41(39-23-11-22-34)40-27(5)24-38-33(28-12-9-8-10-13-28,29-14-18-31(36-6)19-15-29)30-16-20-32(37-7)21-17-30/h8-10,12-21,25-27H,11,23-24H2,1-7H3/t27-,41?/m0/s1
Synonyms: Phosphoramidous acid, bis(1-methylethyl)-, 2-[bis(4-methoxyphenyl)phenylmethoxy]-1-methylethyl 2-cyanoethyl ester, (1S)-

1-DMTr-3-(S)-butanediyl amidite

Description: 1-DMTr-3-(S)-butanediyl amidite is a reagent used in solid-phase oligonucleotide synthesis. This reagent allows for the introduction of a chiral butanediyl spacer into oligonucleotides during synthesis. Chiral spacers can introduce specific properties or functionalities to oligonucleotides, useful for various applications in biotechnology and therapeutics.
CAT: BRP-00957
CAS: 161106-24-7
MF: C34H45N2O5P
MF: 592.72
Purity: >95%
Appearance: Light-yellow oily matter
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InChIKey: QTYXEIMXWNEEOP-DHZXTJRXSA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: N#CCCOP(OC(C)CCOC(C=1C=CC=CC1)(C2=CC=C(OC)C=C2)C3=CC=C(OC)C=C3)N(C(C)C)C(C)C
IUPAC Name: 3-[[(2S)-4-[bis(4-methoxyphenyl)-phenylmethoxy]butan-2-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
InChI: InChI=1S/C34H45N2O5P/c1-26(2)36(27(3)4)42(40-24-11-23-35)41-28(5)22-25-39-34(29-12-9-8-10-13-29,30-14-18-32(37-6)19-15-30)31-16-20-33(38-7)21-17-31/h8-10,12-21,26-28H,11,22,24-25H2,1-7H3/t28-,42?/m0/s1
Synonyms: Phosphoramidous acid, bis(1-methylethyl)-, (1S)-3-[bis(4-methoxyphenyl)phenylmethoxy]-1-methylpropyl 2-cyanoethyl ester; Phosphoramidous acid, bis(1-methylethyl)-, 3-[bis(4-methoxyphenyl)phenylmethoxy]-1-methylpropyl 2-cyanoethyl ester, (1S)-; (S)-4-(bis(4-methoxyphenyl)(phenyl)methoxy)butan-2-yl (2-cyanoethyl) diisopropylphosphoramidite

Propargyl C4 amidite

Description: Propargyl C4 amidite is a reagent used in oligonucleotide synthesis. This reagent allows for the introduction of a propargyl modification of the nucleobase during oligonucleotide synthesis. Propargyl modifications are useful for various applications such as click chemistry reactions for further functionalization or conjugation.
CAT: BRP-00958
CAS: 1173382-08-5
MF: C16H29N2O3P
MF: 328.39
Purity: >95%
Appearance: Light-yellow oily matter
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Storage: Store at -20 °C
InChIKey: LQEYCRIHZDOGRQ-UHFFFAOYSA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: N#CCCOP(OCCCCOCC#C)N(C(C)C)C(C)C
IUPAC Name: 2-cyanoethyl (4-(prop-2-yn-1-yloxy)butyl) diisopropylphosphoramidite
InChI: InChI=1S/C16H29N2O3P/c1-6-11-19-12-7-8-13-20-22(21-14-9-10-17)18(15(2)3)16(4)5/h1,15-16H,7-9,11-14H2,2-5H3
Synonyms: Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl 4-(2-propyn-1-yloxy)butyl ester; 2-Cyanoethyl 4-(2-propyn-1-yloxy)butyl N,N-bis(1-methylethyl)phosphoramidite
* Only for research. Not suitable for any diagnostic or therapeutic use.

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