Phosphoramidites

2'-OMe G(iBu) OBn-amidite

Description: 2'-OMe G(iBu) OBn-amidite is a modified phosphoramidite used in oligonucleotide synthesis. It contains a guanosine nucleoside modified with a 2'-O-methyl (2'-OMe) group and an isobutyl (iBu) protecting group. Additionally, the benzyl (Bn) group is attached to the phosphoramidite moiety. This compound is employed in solid-phase oligonucleotide synthesis to incorporate specifically modified guanosine nucleosides into oligonucleotide sequences. The 2'-O-methyl modification enhances stability, while the isobutyl and benzyl protecting groups provide selective protection during synthesis, allowing precise control over nucleotide incorporation.

CAT: BRP-00930

CAS: 2068810-62-6

Molecular Formula: C49H59N6O9P

Molecular Weight: 907.02

Purity: >95%

Appearance: Off-white solid

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InChIKey: DOXQHYSXYPLQNS-KLJQIIHSSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: O=C1N=C(NC(=O)C(C)C)NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP(OCC=7C=CC=CC7)N(C(C)C)C(C)C)C3OC

IUPAC Name: benzyl ((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl) diisopropylphosphoramidite

InChI: InChI=1S/C49H59N6O9P/c1-31(2)45(56)52-48-51-44-41(46(57)53-48)50-30-54(44)47-43(60-9)42(64-65(55(32(3)4)33(5)6)62-28-34-16-12-10-13-17-34)40(63-47)29-61-49(35-18-14-11-15-19-35,36-20-24-38(58-7)25-21-36)37-22-26-39(59-8)27-23-37/h10-27,30-33,40,42-43,47H,28-29H2,1-9H3,(H2,51,52,53,56,57)/t40-,42-,43-,47-,65?/m1/s1

Synonyms: N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methylguanosine-3'-benzyloxy-phosphoramidite; 5'-O-DMTr-2'-OMe-G(iBu)-3'-benzyloxy-phosphoramidite; N2-iBu 2'-OMe G OBn-amidite; 2'-OMe Guanosine (n-ibu) benzyloxy phosphoramidite

2'-OTIPS 5-propynyl-U Obutyn-amidite

Description: 2'-OTIPS 5-propynyl-U Obutyn-amidite is a modified phosphoramidite used in oligonucleotide synthesis. It contains a uridine nucleoside modified with a 2'-O-triisopropylsilyl (2'-OTIPS) group and a 3-butynyl (Obutyn) group attached to the phosphoramidite moiety. This compound is employed in solid-phase oligonucleotide synthesis to incorporate specifically modified uridine nucleosides into oligonucleotide sequences. The 2'-O-triisopropylsilyl group protects the 2' hydroxyl group, while the 3-butynyl group provides a functional handle for further modification. It allows precise control over nucleotide incorporation and subsequent conjugation or labeling reactions.

CAT: BRP-00931

Molecular Formula: C52H70N3O9PSi

Molecular Weight: 940.20

Purity: >95%

Appearance: Off-white solid

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InChIKey: SCESTXDXTKPIHA-WTWWAFAISA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-5-(prop-1-yn-1-yl)-3,4-dihydropyrimidin-1(2H)-yl)-4-((triisopropylsilyl)oxy)tetrahydrofuran-3-yl but-3-yn-1-yl diisopropylphosphoramidite

InChI: InChI=1S/C52H70N3O9PSi/c1-15-17-32-61-65(55(35(3)4)36(5)6)63-47-46(62-50(54-33-40(21-16-2)49(56)53-51(54)57)48(47)64-66(37(7)8,38(9)10)39(11)12)34-60-52(41-22-19-18-20-23-41,42-24-28-44(58-13)29-25-42)43-26-30-45(59-14)31-27-43/h1,18-20,22-31,33,35-39,46-48,50H,17,32,34H2,2-14H3,(H,53,56,57)/t46-,47-,48-,50-,65?/m1/s1

2'-OMe U Obutyn-amidite

Description: 2'-OMe U Obutyn-amidite is a modified phosphoramidite used in oligonucleotide synthesis. It contains a uridine nucleoside modified with a 2'-O-methyl (2'-OMe) group. This compound is employed in solid-phase oligonucleotide synthesis to incorporate specifically modified uridine nucleosides into oligonucleotide sequences. The 2'-O-methyl group enhances stability. It allows precise control over nucleotide incorporation and subsequent conjugation or labeling reactions.

CAT: BRP-00932

Molecular Formula: C41H50N3O9P

Molecular Weight: 759.84

Purity: >95%

Appearance: Off-white solid

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InChIKey: DDNPMEIKNDZJFN-KCTKLGORSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl but-3-yn-1-yl diisopropylphosphoramidite

InChI: InChI=1S/C41H50N3O9P/c1-9-10-26-51-54(44(28(2)3)29(4)5)53-37-35(52-39(38(37)49-8)43-25-24-36(45)42-40(43)46)27-50-41(30-14-12-11-13-15-30,31-16-20-33(47-6)21-17-31)32-18-22-34(48-7)23-19-32/h1,11-25,28-29,35,37-39H,10,26-27H2,2-8H3,(H,42,45,46)/t35-,37-,38-,39-,54?/m1/s1

2'-OMe A(Bz) Obutyn-amidite

Description: 2'-OMe A(Bz) Obutyn-amidite is a modified phosphoramidite used in oligonucleotide synthesis. It contains an adenosine nucleoside modified with a 2'-O-methyl (2'-OMe) group and a benzoyl (Bz) group, with a 3-butynyl (Obutyn) group attached to the phosphoramidite moiety. This compound is employed in solid-phase oligonucleotide synthesis to incorporate specifically modified adenosine nucleosides into oligonucleotide sequences. The 2'-O-methyl modification enhances stability, while the benzoyl group serves as a protecting group, and the 3-butynyl group provides a functional handle for further modification. It allows precise control over nucleotide incorporation and subsequent conjugation or labeling reactions.

CAT: BRP-00933

CAS: 1840885-68-8

Molecular Formula: C49H55N6O8P

Molecular Weight: 886.99

Purity: >95%

Appearance: Off-white solid

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InChIKey: NEFHXUABIXRDHS-HHRUMCNBSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: O=C(NC1=NC=NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP(OCCC#C)N(C(C)C)C(C)C)C3OC)C=7C=CC=CC7

IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl but-3-yn-1-yl diisopropylphosphoramidite

InChI: InChI=1S/C49H55N6O8P/c1-9-10-29-61-64(55(33(2)3)34(4)5)63-43-41(62-48(44(43)59-8)54-32-52-42-45(50-31-51-46(42)54)53-47(56)35-17-13-11-14-18-35)30-60-49(36-19-15-12-16-20-36,37-21-25-39(57-6)26-22-37)38-23-27-40(58-7)28-24-38/h1,11-28,31-34,41,43-44,48H,10,29-30H2,2-8H3,(H,50,51,53,56)/t41-,43-,44-,48-,64?/m1/s1

Synonyms: Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[3-butyn-1-yl N,N-bis(1-methylethyl)phosphoramidite]

2'-OMe G(iBu) Obutyn-amidite

Description: 2'-OMe G(iBu) Obutyn-amidite is a modified phosphoramidite used in oligonucleotide synthesis. It contains a guanosine nucleoside modified with a 2'-O-methyl (2'-OMe) group and an isobutyl (iBu) group. This compound is utilized in solid-phase oligonucleotide synthesis to introduce specifically modified guanosine nucleosides into oligonucleotide sequences. The 2'-O-methyl modification enhances stability, while the isobutyl group serves as a protecting group, and the 3-butynyl group provides a functional handle for further modification. It allows precise control over nucleotide incorporation and subsequent conjugation or labeling reactions.

CAT: BRP-00934

CAS: 1773534-68-1

Molecular Formula: C46H57N6O9P

Molecular Weight: 868.97

Purity: >97%

Appearance: Off-white solid

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InChIKey: BIFMOLDNUGOVBS-DMWBDYODSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: O=C1N=C(NC(=O)C(C)C)NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP(OCCC#C)N(C(C)C)C(C)C)C3OC

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl but-3-yn-1-yl diisopropylphosphoramidite

InChI: InChI=1S/C46H57N6O9P/c1-11-12-26-59-62(52(30(4)5)31(6)7)61-39-37(60-44(40(39)57-10)51-28-47-38-41(51)48-45(50-43(38)54)49-42(53)29(2)3)27-58-46(32-16-14-13-15-17-32,33-18-22-35(55-8)23-19-33)34-20-24-36(56-9)25-21-34/h1,13-25,28-31,37,39-40,44H,12,26-27H2,2-10H3,(H2,48,49,50,53,54)/t37-,39-,40-,44-,62?/m1/s1

Synonyms: Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-N-(2-methyl-1-oxopropyl)-, 3'-[3-butyn-1-yl N,N-bis(1-methylethyl)phosphoramidite]

2'-OMe U OMe-amidite

Description: 2'-OMe U OMe-amidite is a reagent commonly used in oligonucleotide synthesis. It involves a methyl (Me) group at the 2' position of ribose and incorporates a methoxy (OMe) group directly linked to the phosphoramidite moiety. This allows for the controlled synthesis of modified oligonucleotides with improved stability and specific functionalities.

CAT: BRP-00935

CAS: 110764-77-7

Molecular Formula: C38H48N3O9P

Molecular Weight: 721.79

Purity: >95%

Appearance: White, off-white to faint yellow powder

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InChIKey: ZFAYUVCJJLJWPV-KQBWMQIQSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: O=C1C=CN(C(=O)N1)C2OC(COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)C(OP(OC)N(C(C)C)C(C)C)C2OC

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl methyl diisopropylphosphoramidite

InChI: InChI=1S/C38H48N3O9P/c1-25(2)41(26(3)4)51(47-8)50-34-32(49-36(35(34)46-7)40-23-22-33(42)39-37(40)43)24-48-38(27-12-10-9-11-13-27,28-14-18-30(44-5)19-15-28)29-16-20-31(45-6)21-17-29/h9-23,25-26,32,34-36H,24H2,1-8H3,(H,39,42,43)/t32-,34-,35-,36-,51?/m1/s1

Synonyms: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[methyl bis(1-methylethyl)phosphoramidite]; 5'-O-DMTr-2'-OMe-U-3'-Methoxy-phosphoramidite; 5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyl-uridine-3'-Methoxy-phosphoramidite

2'-OMe A(Bz) OMe-amidite

Description: 2'-OMe A(Bz) OMe-amidite is a reagent used in oligonucleotide synthesis. It features a methyl (Me) group at the 2' position of ribose, adenine (A) possibly protected with a benzoyl (Bz) group, and incorporates a methoxy (OMe) group directly linked to the phosphoramidite moiety. This facilitates the controlled synthesis of modified oligonucleotides with improved stability and specific functionalities.

CAT: BRP-00936

CAS: 110782-30-4

Molecular Formula: C46H53N6O8P

Molecular Weight: 848.94

Purity: >95%

Appearance: White, off-white to faint yellow powder

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InChIKey: LZPPZAAMMANQFD-HLVGMPGCSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: O=C(NC1=NC=NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP(OC)N(C(C)C)C(C)C)C3OC)C=7C=CC=CC7

IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl methyl diisopropylphosphoramidite

InChI: InChI=1S/C46H53N6O8P/c1-30(2)52(31(3)4)61(57-8)60-40-38(59-45(41(40)56-7)51-29-49-39-42(47-28-48-43(39)51)50-44(53)32-15-11-9-12-16-32)27-58-46(33-17-13-10-14-18-33,34-19-23-36(54-5)24-20-34)35-21-25-37(55-6)26-22-35/h9-26,28-31,38,40-41,45H,27H2,1-8H3,(H,47,48,50,53)/t38-,40-,41-,45-,61?/m1/s1

Synonyms: Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[methyl bis(1-methylethyl)phosphoramidite]; 5'-O-DMTr-2'-OMe-A(Bz)-3'-Methoxy-phosphoramidite; N6-benzoyl-5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyl-Adenosine-3'-Methoxy-phosphoramidite

2'-OMe G(iBu) OMe-amidite

Description: 2'-OMe G(iBu) OMe-amidite is a reagent utilized in oligonucleotide synthesis. It consists of a methyl (Me) group at the 2' position of ribose, guanosine (G) potentially protected with an isobutyl (iBu) group, and incorporates a methoxy (OMe) group directly linked to the phosphoramidite moiety. This enables the controlled synthesis of modified oligonucleotides with enhanced stability and tailored functionalities.

CAT: BRP-00937

CAS: 179478-96-7

Molecular Formula: C43H55N6O9P

Molecular Weight: 830.92

Purity: >98%

Appearance: White, off-white to faint yellow powder

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InChIKey: ABXYOPVUGHRVTD-BFXRUIMDSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: O=C1N=C(NC(=O)C(C)C)NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP(OC)N(C(C)C)C(C)C)C3OC

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl methyl diisopropylphosphoramidite

InChI: InChI=1S/C43H55N6O9P/c1-26(2)39(50)46-42-45-38-35(40(51)47-42)44-25-48(38)41-37(54-9)36(58-59(55-10)49(27(3)4)28(5)6)34(57-41)24-56-43(29-14-12-11-13-15-29,30-16-20-32(52-7)21-17-30)31-18-22-33(53-8)23-19-31/h11-23,25-28,34,36-37,41H,24H2,1-10H3,(H2,45,46,47,50,51)/t34-,36-,37-,41-,59?/m1/s1

Synonyms: Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-N-(2-methyl-1-oxopropyl)-, 3'-[methyl bis(1-methylethyl)phosphoramidite]; 5'-O-DMTr-2'-OMe-G(iBu)-3'-Methoxy-phosphoramidite; N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-guanosine-3'-Methoxy-phosphoramidite

2'-MOE MeC(Bz) OMe-amidite

Description: 2'-OMe MeC(Bz) OMe-amidite is a reagent employed in oligonucleotide synthesis. It contains a methyl (Me) group at the 2' position of ribose, cytosine (C) potentially protected with a benzoyl (Bz) group, and incorporates a methoxy (OMe) group directly linked to the phosphoramidite moiety. This facilitates the controlled synthesis of modified oligonucleotides with improved stability and specific functionalities.

CAT: BRP-00938

CAS: 647858-99-9

Molecular Formula: C48H59N4O10P

Molecular Weight: 882.99

Purity: >95%

Appearance: Off-white solid

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InChIKey: GVNBZSNXLHGONB-AENBYTAOSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: O=C1N=C(NC(=O)C=2C=CC=CC2)C(=CN1C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP(OC)N(C(C)C)C(C)C)C3OCCOC)C

IUPAC Name: (2R,3R,4R,5R)-5-(4-benzamido-5-methyl-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl methyl diisopropylphosphoramidite

InChI: InChI=1S/C48H59N4O10P/c1-32(2)52(33(3)4)63(58-9)62-42-41(31-60-48(36-18-14-11-15-19-36,37-20-24-39(56-7)25-21-37)38-22-26-40(57-8)27-23-38)61-46(43(42)59-29-28-55-6)51-30-34(5)44(50-47(51)54)49-45(53)35-16-12-10-13-17-35/h10-27,30,32-33,41-43,46H,28-29,31H2,1-9H3,(H,49,50,53,54)/t41-,42-,43-,46-,63?/m1/s1

Synonyms: Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-5-methyl-, 3'-[methyl bis(1-methylethyl)phosphoramidite]

2'-OMe G(iBu) (TBSO)SATE-amidite

Description: 2'-OMe G(iBu) (TBSO)SATE-amidite is a reagent used in oligonucleotide synthesis. It contains a methyl (Me) group at the 2' position of ribose, guanosine (G) potentially protected with an isobutyl (iBu) group. This reagent enables the controlled synthesis of modified oligonucleotides with enhanced stability and specific functionalities.

CAT: BRP-00939

Molecular Formula: C55H79N6O11PSSi

Molecular Weight: 1091.40

Purity: >95%

Appearance: Off-white solid

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InChIKey: KNYQSRGOAUUKQY-HYFQDGRXSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: S-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethyl) 3-((tert-butyldimethylsilyl)oxy)-2,2-dimethylpropanethioate

InChI: InChI=1S/C55H79N6O11PSSi/c1-35(2)48(62)58-52-57-47-44(49(63)59-52)56-34-60(47)50-46(67-14)45(72-73(61(36(3)4)37(5)6)69-30-31-74-51(64)54(10,11)33-70-75(15,16)53(7,8)9)43(71-50)32-68-55(38-20-18-17-19-21-38,39-22-26-41(65-12)27-23-39)40-24-28-42(66-13)29-25-40/h17-29,34-37,43,45-46,50H,30-33H2,1-16H3,(H2,57,58,59,62,63)/t43-,45-,46-,50-,73?/m1/s1

2'-OMe A(Bz) (TBSO)SATE-amidite

Description: 2'-OMe A(Bz) (TBSO)SATE-amidite is a reagent utilized in oligonucleotide synthesis. It contains a methyl (Me) group at the 2' position of ribose, adenine (A) potentially protected with a benzoyl (Bz) group. This reagent enables the controlled synthesis of modified oligonucleotides with improved stability and specific functionalities.

CAT: BRP-00940

Molecular Formula: C58H77N6O10PSSi

Molecular Weight: 1109.41

Purity: >95%

Appearance: Off-white solid

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InChIKey: BPRJNTIBJAXHFE-SLDILDNQSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: S-(2-(((((2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethyl) 3-((tert-butyldimethylsilyl)oxy)-2,2-dimethylpropanethioate

InChI: InChI=1S/C58H77N6O10PSSi/c1-39(2)64(40(3)4)75(71-33-34-76-55(66)57(8,9)36-72-77(13,14)56(5,6)7)74-49-47(73-54(50(49)69-12)63-38-61-48-51(59-37-60-52(48)63)62-53(65)41-21-17-15-18-22-41)35-70-58(42-23-19-16-20-24-42,43-25-29-45(67-10)30-26-43)44-27-31-46(68-11)32-28-44/h15-32,37-40,47,49-50,54H,33-36H2,1-14H3,(H,59,60,62,65)/t47-,49-,50-,54-,75?/m1/s1

2'-OMe C(Bz) (TBSO)SATE-amidite

Description: 2'-OMe C(Bz) (TBSO)SATE-amidite is a reagent used in oligonucleotide synthesis. It contains a methyl (Me) group at the 2' position of ribose, cytosine (C) potentially protected with a benzoyl (Bz) group. This reagent facilitates the controlled synthesis of modified oligonucleotides with enhanced stability and specific functionalities.

CAT: BRP-00941

Molecular Formula: C57H77N4O11PSSi

Molecular Weight: 1085.39

Purity: >95%

Appearance: Off-white solid

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InChIKey: IGTHQWLLAPOEKK-LEOYGVFQSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: S-(2-(((((2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethyl) 3-((tert-butyldimethylsilyl)oxy)-2,2-dimethylpropanethioate

InChI: InChI=1S/C57H77N4O11PSSi/c1-39(2)61(40(3)4)73(69-35-36-74-53(63)56(8,9)38-70-75(13,14)55(5,6)7)72-49-47(71-52(50(49)67-12)60-34-33-48(59-54(60)64)58-51(62)41-21-17-15-18-22-41)37-68-57(42-23-19-16-20-24-42,43-25-29-45(65-10)30-26-43)44-27-31-46(66-11)32-28-44/h15-34,39-40,47,49-50,52H,35-38H2,1-14H3,(H,58,59,62,64)/t47-,49-,50-,52-,73?/m1/s1

2'-OMe U (TBSO)SATE-amidite

Description: 2'-OMe U (TBSO)SATE-amidite is a reagent utilized in oligonucleotide synthesis. It contains a methyl (Me) group at the 2' position of ribose and incorporates uracil (U). This reagent facilitates the controlled synthesis of modified oligonucleotides with enhanced stability and specific functionalities, possibly through the introduction of protecting groups or linkers.

CAT: BRP-00942

Molecular Formula: C50H72N3O11PSSi

Molecular Weight: 982.26

Purity: >95%

Appearance: Off-white solid

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InChIKey: JPIPEHQBJWFYBS-DLBBVOJMSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: S-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethyl) 3-((tert-butyldimethylsilyl)oxy)-2,2-dimethylpropanethioate

InChI: InChI=1S/C50H72N3O11PSSi/c1-34(2)53(35(3)4)65(61-30-31-66-46(55)49(8,9)33-62-67(13,14)48(5,6)7)64-43-41(63-45(44(43)59-12)52-29-28-42(54)51-47(52)56)32-60-50(36-18-16-15-17-19-36,37-20-24-39(57-10)25-21-37)38-22-26-40(58-11)27-23-38/h15-29,34-35,41,43-45H,30-33H2,1-14H3,(H,51,54,56)/t41-,43-,44-,45-,65?/m1/s1

2'-OMe U PACE amidite

Description: 2'-OMe U PACE amidite is a reagent employed in oligonucleotide synthesis. It features a methyl (Me) group at the 2' position of ribose and contains uracil (U). 'PACE' likely refers to a specific modification or functional group incorporated into the nucleotide. This reagent facilitates the controlled synthesis of modified oligonucleotides with specific properties or functionalities, although the exact nature of 'PACE' would determine its specific role in the synthesis process.

CAT: BRP-00943

CAS: 411234-28-1

Molecular Formula: C44H55N4O10P

Molecular Weight: 830.92

Purity: >98%

Appearance: White to off-white powder

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InChIKey: KZVIZOJLWDQWHO-VJPJVJEPSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(CC(=O)OC(C)(C)CC#N)OC1C(OC(C1OC)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: (1-cyano-2-methylpropan-2-yl) 2-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(2,4-dioxopyrimidin-1-yl)-4-methoxyoxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]acetate

InChI: InChI=1S/C44H55N4O10P/c1-29(2)48(30(3)4)59(28-38(50)57-43(5,6)24-25-45)58-39-36(56-41(40(39)54-9)47-26-23-37(49)46-42(47)51)27-55-44(31-13-11-10-12-14-31,32-15-19-34(52-7)20-16-32)33-17-21-35(53-8)22-18-33/h10-23,26,29-30,36,39-41H,24,27-28H2,1-9H3,(H,46,49,51)/t36-,39-,40-,41-,59?/m1/s1

Synonyms: 2'-OMe U PACE amidite; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[P-[2-(2-cyano-1,1-dimethylethoxy)-2-oxoethyl]-N,N-bis(1-methylethyl)phosphonamidite]; 1-Cyano-2-methylpropan-2-yl 2-((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)acetate; 5'-O-DMTr-2'-O-Me-U PACE; 3'-O-(Diisopropylamino)phosphinoacetic acid α,α-dimethyl-β-cyanoethyl methyl ester 5'-O-(4,4'-dimethoxytrityl)-2'-O-methyluridine; 5'-Dimethoxytrityl-2'-OMe-Uridine, 3'-O-(N,N-diisopropylamino)-phosphinyl-1,1-dimethyl-2-cyanoethyl acetate

2'-OMe C(Ac) PACE amidite

Description: 2'-OMe C(Ac) PACE amidite is a reagent used in oligonucleotide synthesis. It contains a methyl (Me) group at the 2' position of ribose, cytosine (C) potentially protected with an acetyl (Ac) group, and incorporates a modification referred to as 'PACE'. This modification might introduce specific functionalities or properties to the oligonucleotide. The exact nature of 'PACE' would determine its role in the synthesis process and the properties of the resulting oligonucleotide.

CAT: BRP-00944

CAS: 1355047-25-4

Molecular Formula: C46H58N5O10P

Molecular Weight: 871.97

Purity: >98%

Appearance: White solid

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InChIKey: RQLMSVYEXLXTTN-YQKQXIHOSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(CC(=O)OC(C)(C)CC#N)OC1C(OC(C1OC)N2C=CC(=NC2=O)NC(=O)C)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: (1-cyano-2-methylpropan-2-yl) 2-[[(2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1-yl)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-methoxyoxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]acetate

InChI: InChI=1S/C46H58N5O10P/c1-30(2)51(31(3)4)62(29-40(53)60-45(6,7)25-26-47)61-41-38(59-43(42(41)57-10)50-27-24-39(48-32(5)52)49-44(50)54)28-58-46(33-14-12-11-13-15-33,34-16-20-36(55-8)21-17-34)35-18-22-37(56-9)23-19-35/h11-24,27,30-31,38,41-43H,25,28-29H2,1-10H3,(H,48,49,52,54)/t38-,41-,42-,43-,62?/m1/s1

Synonyms: 2'-OMe C(Ac) PACE amidite; Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[P-[2-(2-cyano-1,1-dimethylethoxy)-2-oxoethyl]-N,N-bis(1-methylethyl)phosphonamidite]; 1-Cyano-2-methylpropan-2-yl 2-((((2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)acetate; 5'-O-DMTr-2'-O-Me-C(Ac) PACE; 3'-O-(Diisopropylamino)phosphinoacetic acid α,α-dimethyl-β-cyanoethyl methyl ester N4-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methylcytidine

2'-OMe A(Bz) PACE amidite

Description: 2'-OMe A(Bz) PACE amidite is a reagent utilized in oligonucleotide synthesis. It contains a methyl (Me) group at the 2' position of ribose, adenine (A) potentially protected with a benzoyl (Bz) group, and incorporates a modification known as 'PACE'. This modification introduces specific functionalities or properties to the oligonucleotide. The exact nature of 'PACE' would dictate its role in the synthesis process and the characteristics of the resulting oligonucleotide.

CAT: BRP-00945

CAS: 1355047-24-3

Molecular Formula: C52H60N7O9P

Molecular Weight: 958.07

Purity: >97%

Appearance: White solid

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InChIKey: JWEJRQXHPXDTPT-GCZIAXJXSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(CC(=O)OC(C)(C)CC#N)OC1C(OC(C1OC)N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC

IUPAC Name: (1-cyano-2-methylpropan-2-yl) 2-[[(2R,3R,4R,5R)-5-(6-benzamidopurin-9-yl)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-methoxyoxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]acetate

InChI: InChI=1S/C52H60N7O9P/c1-34(2)59(35(3)4)69(31-43(60)67-51(5,6)28-29-53)68-45-42(66-50(46(45)64-9)58-33-56-44-47(54-32-55-48(44)58)57-49(61)36-16-12-10-13-17-36)30-65-52(37-18-14-11-15-19-37,38-20-24-40(62-7)25-21-38)39-22-26-41(63-8)27-23-39/h10-27,32-35,42,45-46,50H,28,30-31H2,1-9H3,(H,54,55,57,61)/t42-,45-,46-,50-,69?/m1/s1

Synonyms: 2'-OMe A(Bz) PACE amidite; Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[P-[2-(2-cyano-1,1-dimethylethoxy)-2-oxoethyl]-N,N-bis(1-methylethyl)phosphonamidite]; 1-Cyano-2-methylpropan-2-yl 2-((((2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)acetate

2'-OMe G(iBu) PACE amidite

Description: 2'-OMe G(iBu) PACE amidite is a reagent used in oligonucleotide synthesis. It contains a methyl (Me) group at the 2' position of ribose, guanosine (G) potentially protected with an isobutyl (iBu) group, and incorporates a modification referred to as 'PACE'. This modification introduces specific functionalities or properties to the oligonucleotide. The exact nature of 'PACE' would determine its role in the synthesis process and the characteristics of the resulting oligonucleotide.

CAT: BRP-00946

CAS: 1355047-26-5

Molecular Formula: C49H62N7O10P

Molecular Weight: 940.05

Purity: >98%

Appearance: White solid

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InChIKey: IEFSKQYVGBGNHJ-GGUIJGGTSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(CC(=O)OC(C)(C)CC#N)N(C(C)C)C(C)C)OC

IUPAC Name: (1-cyano-2-methylpropan-2-yl) 2-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-methoxy-5-[2-(2-methylpropanoylamino)-6-oxo-1H-purin-9-yl]oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]acetate

InChI: InChI=1S/C49H62N7O10P/c1-30(2)44(58)53-47-52-43-40(45(59)54-47)51-29-55(43)46-42(62-11)41(66-67(56(31(3)4)32(5)6)28-39(57)65-48(7,8)25-26-50)38(64-46)27-63-49(33-15-13-12-14-16-33,34-17-21-36(60-9)22-18-34)35-19-23-37(61-10)24-20-35/h12-24,29-32,38,41-42,46H,25,27-28H2,1-11H3,(H2,52,53,54,58,59)/t38-,41-,42-,46-,67?/m1/s1

Synonyms: 2'-OMe G(iBu) PACE amidite; 5'-Dimethoxytrityl-N-isobutyryl-2'-OMe-Guanosine, 3'-O-(N,N-diisopropylamino)-phosphinyl-1,1-dimethyl-2-cyanoethyl acetate; Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-N-(2-methyl-1-oxopropyl)-, 3'-[P-[2-(2-cyano-1,1-dimethylethoxy)-2-oxoethyl]-N,N-bis(1-methylethyl)phosphonamidite]; 1-Cyano-2-methylpropan-2-yl 2-((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)acetate

2'-OTBS U ThioPhosphamidite

Description: 2'-OTBS U ThioPhosphamidite is a reagent used in oligonucleotide synthesis. It contains a tert-butyldimethylsilyl (TBS) protecting group at the 2' position of ribose, uracil (U), and incorporates a thio modification. ThioPhosphamidite suggests the presence of a phosphoramidite moiety with a thiol (-SH) group attached. This reagent allows for the controlled synthesis of oligonucleotides with thio modifications, which can impart specific chemical or biological properties to the resulting oligonucleotide sequences.

CAT: BRP-00947

CAS: 1374755-68-6

Molecular Formula: C49H60N3O9PS2Si

Molecular Weight: 958.23

Purity: >98%

Appearance: Off-white solid

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InChIKey: CSXWIDBTNRBSQY-CRHOWCKESA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)(C)[Si](C)(C)OC1C(C(OC1N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OP(N6CCCC6)SCCSC(=O)C7=CC=CC=C7

IUPAC Name: S-[2-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-5-(2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-pyrrolidin-1-ylphosphanyl]sulfanylethyl] benzenecarbothioate

InChI: InChI=1S/C49H60N3O9PS2Si/c1-48(2,3)65(6,7)61-44-43(60-62(51-29-14-15-30-51)64-33-32-63-46(54)35-16-10-8-11-17-35)41(59-45(44)52-31-28-42(53)50-47(52)55)34-58-49(36-18-12-9-13-19-36,37-20-24-39(56-4)25-21-37)38-22-26-40(57-5)27-23-38/h8-13,16-28,31,41,43-45H,14-15,29-30,32-34H2,1-7H3,(H,50,53,55)/t41-,43-,44-,45-,62?/m1/s1

Synonyms: 5'-DMT-2'-OTBS-U-3'-PS-Phosphoramidite; DMT-2'-OTBS-U-3'-PS; S-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)oxy)(pyrrolidin-1-yl)phosphaneyl)thio)ethyl) benzothioate; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-[S-[2-(benzoylthio)ethyl] P-1-pyrrolidinylphosphonothioite]

2'-OTBS A(Bz) ThioPhosphamidite

Description: 2'-OTBS A(Bz) ThioPhosphamidite is a reagent used in oligonucleotide synthesis. It contains a tert-butyldimethylsilyl (TBS) protecting group at the 2' position of ribose, adenine (A) potentially protected with a benzoyl (Bz) group, and incorporates a thio modification. ThioPhosphamidite suggests the presence of a phosphoramidite moiety with a thiol (-SH) group attached. This reagent enables the controlled synthesis of oligonucleotides with thio modifications, offering specific chemical or biological functionalities to the resulting sequences.

CAT: BRP-00948

CAS: 1374755-65-3

Molecular Formula: C57H65N6O8PS2Si

Molecular Weight: 1085.38

Purity: >95%

Appearance: Off-white solid

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InChIKey: ALJIYXCITZABFP-WOMFGPHHSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)(C)[Si](C)(C)OC1C(C(OC1N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC)OP(N8CCCC8)SCCSC(=O)C9=CC=CC=C9

IUPAC Name: S-[2-[[(2R,3R,4R,5R)-5-(6-benzamidopurin-9-yl)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxyoxolan-3-yl]oxy-pyrrolidin-1-ylphosphanyl]sulfanylethyl] benzenecarbothioate

InChI: InChI=1S/C57H65N6O8PS2Si/c1-56(2,3)75(6,7)71-50-49(70-72(62-33-17-18-34-62)74-36-35-73-55(65)41-21-13-9-14-22-41)47(69-54(50)63-39-60-48-51(58-38-59-52(48)63)61-53(64)40-19-11-8-12-20-40)37-68-57(42-23-15-10-16-24-42,43-25-29-45(66-4)30-26-43)44-27-31-46(67-5)32-28-44/h8-16,19-32,38-39,47,49-50,54H,17-18,33-37H2,1-7H3,(H,58,59,61,64)/t47-,49-,50-,54-,72?/m1/s1

Synonyms: 5'-DMT-2'-OTBS-A(Bz)-3'-PS-Phosphoramidite; S-(2-(((((2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl)oxy)(pyrrolidin-1-yl)phosphaneyl)thio)ethyl) benzothioate; Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-[S-[2-(benzoylthio)ethyl] P-1-pyrrolidinylphosphonothioite]; DMT-2'-OTBS-A(Bz)-3'-PS

2'-OTBS C(Ac) ThioPhosphamidite

Description: 2'-OTBS C(Ac) ThioPhosphamidite is a reagent used in oligonucleotide synthesis. It contains a tert-butyldimethylsilyl (TBS) protecting group at the 2' position of ribose, cytosine (C) potentially protected with an acetyl (Ac) group, and incorporates a thio modification. ThioPhosphamidite suggests the presence of a phosphoramidite moiety with a thiol (-SH) group attached. This reagent facilitates the controlled synthesis of oligonucleotides with thio modifications, providing specific chemical or biological functionalities to the resulting sequences.

CAT: BRP-00949

CAS: 1374755-66-4

Molecular Formula: C51H63N4O9PS2Si

Molecular Weight: 999.28

Purity: >98%

Appearance: Off-white solid

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InChIKey: KEDMUXPEKPOPCR-YTFDKTRSSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(=O)NC1=NC(=O)N(C=C1)C2C(C(C(O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OP(N6CCCC6)SCCSC(=O)C7=CC=CC=C7)O[Si](C)(C)C(C)(C)C

IUPAC Name: S-[2-[[(2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1-yl)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxyoxolan-3-yl]oxy-pyrrolidin-1-ylphosphanyl]sulfanylethyl] benzenecarbothioate

InChI: InChI=1S/C51H63N4O9PS2Si/c1-36(56)52-44-29-32-55(49(58)53-44)47-46(64-68(7,8)50(2,3)4)45(63-65(54-30-15-16-31-54)67-34-33-66-48(57)37-17-11-9-12-18-37)43(62-47)35-61-51(38-19-13-10-14-20-38,39-21-25-41(59-5)26-22-39)40-23-27-42(60-6)28-24-40/h9-14,17-29,32,43,45-47H,15-16,30-31,33-35H2,1-8H3,(H,52,53,56,58)/t43-,45-,46-,47-,65?/m1/s1

Synonyms: 5'-DMT-2'-OTBS-C(Ac)-3'-PS-Phosphoramidite; DMT-2'-OTBS-C(Ac)-3'-PS; Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-[S-[2-(benzoylthio)ethyl] P-1-pyrrolidinylphosphonothioite]; S-(2-(((((2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl)oxy)(pyrrolidin-1-yl)phosphaneyl)thio)ethyl) benzothioate

2'-OMe G(iBu) OBn-amidite

2'-OTIPS 5-propynyl-U Obutyn-amidite

2'-OMe U Obutyn-amidite

2'-OMe A(Bz) Obutyn-amidite

2'-OMe G(iBu) Obutyn-amidite

2'-OMe U OMe-amidite

2'-OMe A(Bz) OMe-amidite

2'-OMe G(iBu) OMe-amidite

2'-MOE MeC(Bz) OMe-amidite

2'-OMe G(iBu) (TBSO)SATE-amidite

2'-OMe A(Bz) (TBSO)SATE-amidite

2'-OMe C(Bz) (TBSO)SATE-amidite

2'-OMe U (TBSO)SATE-amidite

2'-OMe U PACE amidite

2'-OMe C(Ac) PACE amidite

2'-OMe A(Bz) PACE amidite

2'-OMe G(iBu) PACE amidite

2'-OTBS U ThioPhosphamidite

2'-OTBS A(Bz) ThioPhosphamidite

2'-OTBS C(Ac) ThioPhosphamidite

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