Phosphoramidites - RNA / BOC Sciences

O6-Protected-5'-DMT-2'-OMe-G(iBu)-CE-Phosphoramidite

Description: This phosphoramidite derivative introduces a guanosine nucleoside modified with a 2'-OMe group (2'-O-methyl) and protected at the O6 position with a specific protecting group. It is protected at the 5'-position with a dimethoxytrityl (DMT) group and at the 3'-position with a cyanoethyl (CE) group. Such modifications are crucial for studying RNA structure and function, including RNA stability and interactions with proteins or small molecules.

CAT: BRP-01117

MF: C57H70N7O11P

MF: 1060.18

Purity: ≥98% by HPLC

Appearance: White to off-white powder

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InChIKey: NZGAIHSRQZRTST-VQLBZFODSA-N

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=N1)OCC3=CC=C(C=C3)OC(=O)C(C)(C)C)N=CN2C4C(C(C(O4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC)OP(N(C(C)C)C(C)C)OCCC#N)OC

IUPAC Name: [4-[[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-methoxyoxolan-2-yl]-2-(2-methylpropanoylamino)purin-6-yl]oxymethyl]phenyl] 2,2-dimethylpropanoate

InChI: InChI=1S/C57H70N7O11P/c1-36(2)51(65)61-55-60-50-47(52(62-55)70-33-39-19-25-45(26-20-39)73-54(66)56(7,8)9)59-35-63(50)53-49(69-12)48(75-76(72-32-16-31-58)64(37(3)4)38(5)6)46(74-53)34-71-57(40-17-14-13-15-18-40,41-21-27-43(67-10)28-22-41)42-23-29-44(68-11)30-24-42/h13-15,17-30,35-38,46,48-49,53H,16,32-34H2,1-12H3,(H,60,61,62,65)/t46-,48-,49-,53-,76?/m1/s1

Synonyms: O6-(p-Tolyl pivalate)-N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-guanosine-3'-cyanoethyl phosphoramidite; 4-(((9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-3-methoxytetrahydrofuran-2-yl)-2-isobutyramido-9H-purin-6-yl)oxy)methyl)phenyl pivalate; O6-(p-Tolyl pivalate)-5'-DMT-2'-OMe-G(iBu)-CE-Phosphoramidite

DMT-1'-urea-2'-O-Me Amidite

Description: This amidite derivative is used in solid-phase synthesis to introduce a modified nucleoside where the 2'-hydroxyl group is protected with a methyl group (2'-O-methyl) and the 1'-position is protected with a urea moiety. This modification can stabilize RNA structures and enhance binding affinity in biochemical and therapeutic applications.

CAT: BRP-01118

MF: C37H49N4O8P

MF: 708.79

Purity: ≥95% by HPLC

Appearance: White to off-white powder

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InChIKey: CHPGSEHZXRWFRA-JZDAHGDVSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(NC(=O)N)C1OC)COC(C=2C=CC=CC2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxy-5-ureidotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C37H49N4O8P/c1-25(2)41(26(3)4)50(47-23-11-22-38)49-33-32(48-35(34(33)45-7)40-36(39)42)24-46-37(27-12-9-8-10-13-27,28-14-18-30(43-5)19-15-28)29-16-20-31(44-6)21-17-29/h8-10,12-21,25-26,32-35H,11,23-24H2,1-7H3,(H3,39,40,42)/t32-,33-,34-,35-,50?/m1/s1

Synonyms: 5'-O-(4,4'-Dimethoxytrityl)-1'-urea-2'-O-methyl phosphoramidite

5'-BzH-2'-OMe-Ur-3'-Methoxyphosphoramidite

Description: This phosphoramidite introduces a uridine nucleoside modified with a benzoylhydrazine (BzH) group at the 5'-position, a 2'-O-methyl group, and protected at the 3'-position with a methoxy group. Such modifications are used in RNA research to study RNA-protein interactions, RNA stability, and enzymatic processes.

CAT: BRP-01119

MF: C36H58N3O10PSi3

MF: 808.09

Purity: ≥97% by HPLC

Appearance: Colorless or faint yellow oily matter

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InChIKey: CDIAPRHBHZFMSI-UZMHDONASA-N

IUPAC Name: (2R,3R,4R,5R)-2-(((3-(benzhydryloxy)-1,1,1,5,5,5-hexamethyltrisiloxan-3-yl)oxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl methyl diisopropylphosphoramidite

InChI: InChI=1S/C36H58N3O10PSi3/c1-26(2)39(27(3)4)50(43-6)46-33-30(45-35(34(33)42-5)38-24-23-31(40)37-36(38)41)25-44-53(48-51(7,8)9,49-52(10,11)12)47-32(28-19-15-13-16-20-28)29-21-17-14-18-22-29/h13-24,26-27,30,32-35H,25H2,1-12H3,(H,37,40,41)/t30-,33-,34-,35-,50?/m1/s1

Synonyms: 5'-BzH-2'-O-methyl-Uridine-3'-Methoxyphosphoramidite

5'-BzH-2'-OMe-Ac-Cr-3'-Methoxyphosphoramidite

Description: This phosphoramidite introduces an adenosine nucleoside modified with a benzoylhydrazine (BzH) group at the 5'-position, a 2'-O-methyl group, an acetyl group, and protected at the 3'-position with a methoxy group. Modifications like these are employed in RNA chemical biology to probe RNA structure and function, as well as for therapeutic applications.

CAT: BRP-01120

MF: C38H61N4O10PSi3

MF: 849.14

Purity: ≥97% by HPLC

Appearance: Colorless or faint yellow oily matter

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InChIKey: UYPJICYBURNHSL-MCXUBDGSSA-N

IUPAC Name: (2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-(((3-(benzhydryloxy)-1,1,1,5,5,5-hexamethyltrisiloxan-3-yl)oxy)methyl)-4-methoxytetrahydrofuran-3-yl methyl diisopropylphosphoramidite

InChI: InChI=1S/C38H61N4O10PSi3/c1-27(2)42(28(3)4)53(46-7)49-35-32(48-37(36(35)45-6)41-25-24-33(39-29(5)43)40-38(41)44)26-47-56(51-54(8,9)10,52-55(11,12)13)50-34(30-20-16-14-17-21-30)31-22-18-15-19-23-31/h14-25,27-28,32,34-37H,26H2,1-13H3,(H,39,40,43,44)/t32-,35-,36-,37-,53?/m1/s1

Synonyms: 5'-BzH-2'-O-methyl-Ac-Cytidine-3'-Methoxyphosphoramidite

O4-(p-tolyl pivalate)-5'-DMT-2'-OMe-U Phosphoramidite

Description: This phosphoramidite derivative introduces a uridine nucleoside modified at the O4 position with a p-tolyl pivalate group, protected at the 5'-position with a dimethoxytrityl (DMT) group, and at the 2'-position with a methyl group (2'-O-methyl). This modification can alter RNA structure and stability, influencing interactions with RNA-binding proteins and small molecules.

CAT: BRP-01121

MF: C52H63N4O11P

MF: 951.05

Purity: ≥98% by HPLC

Appearance: White to off-white powder

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InChIKey: PJMYGKOZFBVJOS-WLKQIKNLSA-N

IUPAC Name: 4-(((1-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-3-methoxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)oxy)methyl)phenyl pivalate

InChI: InChI=1S/C52H63N4O11P/c1-35(2)56(36(3)4)68(64-32-14-30-53)67-46-44(34-63-52(38-15-12-11-13-16-38,39-19-25-41(59-8)26-20-39)40-21-27-42(60-9)28-22-40)66-48(47(46)61-10)55-31-29-45(54-50(55)58)62-33-37-17-23-43(24-18-37)65-49(57)51(5,6)7/h11-13,15-29,31,35-36,44,46-48H,14,32-34H2,1-10H3/t44-,46-,47-,48-,68?/m1/s1

Synonyms: O4-(p-tolyl pivalate)-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-uridine-3'-cyanoethyl Phosphoramidite

Abasic MOE amidite (α,β mix)

Description: This amidite derivative introduces an abasic site mimic using a methoxyethyl (MOE) group, where the α and β anomeric forms are mixed. Abasic modifications are useful in RNA research to study the effects of missing bases on RNA structure and function.

CAT: BRP-01122

MF: C44H65N2O9PSi

MF: 825.05

Purity: ≥90% by HPLC

Appearance: Clear colorless to yellow oily matter

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InChIKey: OHGFRENWOYSROB-AQJVDKPMSA-N

IUPAC Name: (2R,3R,4R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-((tert-butyldimethylsilyl)oxy)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C44H65N2O9PSi/c1-32(2)46(33(3)4)56(52-28-16-27-45)54-40-39(53-42(41(40)50-30-29-47-8)55-57(11,12)43(5,6)7)31-51-44(34-17-14-13-15-18-34,35-19-23-37(48-9)24-20-35)36-21-25-38(49-10)26-22-36/h13-15,17-26,32-33,39-42H,16,28-31H2,1-12H3/t39-,40-,41-,42?,56?/m1/s1

Synonyms: Abasic MOE amidite (mixture of alpha and beta)

2,6-diamino(N2,N6-diiBu)-DMT-2'-O-MOE-purine riboside-CE-Phosphoramidite

Description: This phosphoramidite introduces a purine riboside nucleoside modified with 2,6-diamino groups at the N2 and N6 positions, protected with a dimethoxytrityl (DMT) group at the 5'-position, and a methoxyethyl (MOE) group at the 2'-position. Such modifications can enhance RNA binding affinity and stability, useful in RNA structure studies and therapeutic RNA design.

CAT: BRP-01123

MF: C51H67N8O10P

MF: 983.10

Purity: ≥90% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: NHUMZBQEINRZEF-RTHUGTBQSA-N

CanonicalSMILES: CC(C)C(=O)NC1=C2C(=NC(=N1)NC(=O)C(C)C)N(C=N2)C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N(C(C)C)C(C)C)OCCC#N)OCCOC

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-(2-methoxyethoxy)oxolan-2-yl]-2-(2-methylpropanoylamino)purin-6-yl]-2-methylpropanamide

InChI: InChI=1S/C51H67N8O10P/c1-32(2)47(60)54-45-42-46(56-50(55-45)57-48(61)33(3)4)58(31-53-42)49-44(65-29-28-62-9)43(69-70(67-27-15-26-52)59(34(5)6)35(7)8)41(68-49)30-66-51(36-16-13-12-14-17-36,37-18-22-39(63-10)23-19-37)38-20-24-40(64-11)25-21-38/h12-14,16-25,31-35,41,43-44,49H,15,27-30H2,1-11H3,(H2,54,55,56,57,60,61)/t41-,43-,44-,49-,70?/m1/s1

Synonyms: 2,6-diamino(N2,N6-diisobutyryl)-5'-O-(4,4'-Dimethoxytrityl)-2'-O-methoxyethyl-purine riboside-3'-cyanoethyl Phosphoramidite; (2R,3R,4R,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,6-diisobutyramido-9H-purin-9-yl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

5'-DMT-2'-O-NMA-5-Me-U-3'-CE-Phosphoramidite

Description: This phosphoramidite introduces a uridine nucleoside modified with a dimethoxytrityl (DMT) group at the 5'-position, a 2'-O-N-methylamino (NMA) group, and a methyl group at the 5-position, protected with a cyanoethyl (CE) group at the 3'-position. This modification can influence RNA structure and function, including RNA-protein interactions and stability.

CAT: BRP-01124

CAS: 1025783-16-7

MF: C43H54N5O10P

MF: 831.89

Purity: ≥98% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: FYNKMLIMLHVWST-FMMLDEGOSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=C(C(=O)NC2=O)C)C1OCC(=O)NC)COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-(2-(methylamino)-2-oxoethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C43H54N5O10P/c1-28(2)48(29(3)4)59(56-24-12-23-44)58-38-36(57-41(39(38)54-27-37(49)45-6)47-25-30(5)40(50)46-42(47)51)26-55-43(31-13-10-9-11-14-31,32-15-19-34(52-7)20-16-32)33-17-21-35(53-8)22-18-33/h9-11,13-22,25,28-29,36,38-39,41H,12,24,26-27H2,1-8H3,(H,45,49)(H,46,50,51)/t36-,38-,39-,41-,59?/m1/s1

Synonyms: [5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(methylamino)-2-oxoethyl]-5-methyluridine]-3'-[(2-cyanoethyl)-N,N-diisopropyl]phosphoramidite; 2'-O-NMA 5-Me-U amidite; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-5-methyl-2'-O-[2-(methylamino)-2-oxoethyl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

5'-O-DMTr-2'-O-TMBTM-A(Bz)-3'-CE-Phosphoramidite

Description: 5'-O-DMTr-2'-O-TMBTM-A(Bz)-3'-CE-Phosphoramidite is a modified adenine nucleoside phosphoramidite used in DNA and RNA synthesis. It features a DMTr (dimethoxytrityl) protecting group at the 5' position, a TMBTM (trimethoxybenzylthiomethyl) group at the 2' position, and a benzoyl-protected adenine base. This compound is essential for the synthesis of oligonucleotides with enhanced stability and functionality for use in genetic research and biotechnology.

CAT: BRP-01125

MF: C58H66N7O11PS

MF: 1100.24

Purity: ≥97% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: XJUICBHZUQLUOH-WMPDMCAKSA-N

IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2,4,6-trimethoxybenzyl)thio)methoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C58H66N7O11PS/c1-38(2)65(39(3)4)77(74-30-16-29-59)76-52-50(33-73-58(41-19-14-11-15-20-41,42-21-25-44(67-5)26-22-42)43-23-27-45(68-6)28-24-43)75-57(53(52)72-37-78-34-47-48(70-8)31-46(69-7)32-49(47)71-9)64-36-62-51-54(60-35-61-55(51)64)63-56(66)40-17-12-10-13-18-40/h10-15,17-28,31-32,35-36,38-39,50,52-53,57H,16,30,33-34,37H2,1-9H3,(H,60,61,63,66)/t50-,52-,53-,57-,77?/m1/s1

Synonyms: N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(2,4,6-trimethoxybenzylthiomethyl)-adenosine-3'-cyanoethyl Phosphoramidite

5'-O-DMTr-2'-O-TMBTM-C(Bz)-3'-CE-Phosphoramidite

Description: This phosphoramidite introduces a cytidine nucleoside where the 2'-hydroxyl group is modified with a TMBTM group and protected with a dimethoxytrityl (DMTr) group at the 5'-position. It is also modified with a benzoyl (Bz) group at the 3'-position and protected with a cyanoethyl (CE) group. Such modifications can enhance RNA stability and specificity in biochemical and therapeutic applications.

CAT: BRP-01126

CAS: 2253978-43-5

MF: C57H66N5O12PS

MF: 1076.21

Purity: ≥97% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: JILKHWGHHKCHDX-LEGKXAINSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=CC(=NC2=O)NC(=O)C=3C=CC=CC3)C1OCSCC=4C(OC)=CC(OC)=CC4OC)COC(C=5C=CC=CC5)(C6=CC=C(OC)C=C6)C7=CC=C(OC)C=C7)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2,4,6-trimethoxybenzyl)thio)methoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C57H66N5O12PS/c1-38(2)62(39(3)4)75(72-32-16-30-58)74-52-50(35-71-57(41-19-14-11-15-20-41,42-21-25-44(65-5)26-22-42)43-23-27-45(66-6)28-24-43)73-55(61-31-29-51(60-56(61)64)59-54(63)40-17-12-10-13-18-40)53(52)70-37-76-36-47-48(68-8)33-46(67-7)34-49(47)69-9/h10-15,17-29,31,33-34,38-39,50,52-53,55H,16,32,35-37H2,1-9H3,(H,59,60,63,64)/t50-,52-,53-,55-,75?/m1/s1

Synonyms: N4-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(2,4,6-trimethoxybenzylthiomethyl)-cytidine-3'-cyanoethyl Phosphoramidite

5'-O-DMTr-2'-O-TMBTM-G(iBu)-3'-CE-Phosphoramidite

Description: This phosphoramidite introduces a guanosine nucleoside where the 2'-hydroxyl group is modified with a TMBTM group and protected with a DMTr group at the 5'-position. It is modified with an isobutyryl (iBu) group at the 3'-position and protected with a CE group. Modifications like these can enhance RNA structure and function, impacting gene expression and regulatory mechanisms.

CAT: BRP-01127

CAS: 2253978-42-4

MF: C55H68N7O12PS

MF: 1082.22

Purity: ≥97% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: ZUFAHXPFYJOCTP-DRQNSODDSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C(=O)N=C(NC(=O)C(C)C)NC32)C1OCSCC=4C(OC)=CC(OC)=CC4OC)COC(C=5C=CC=CC5)(C6=CC=C(OC)C=C6)C7=CC=C(OC)C=C7)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(((2,4,6-trimethoxybenzyl)thio)methoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C55H68N7O12PS/c1-34(2)51(63)59-54-58-50-47(52(64)60-54)57-32-61(50)53-49(70-33-76-31-43-44(68-10)28-42(67-9)29-45(43)69-11)48(74-75(72-27-15-26-56)62(35(3)4)36(5)6)46(73-53)30-71-55(37-16-13-12-14-17-37,38-18-22-40(65-7)23-19-38)39-20-24-41(66-8)25-21-39/h12-14,16-25,28-29,32,34-36,46,48-49,53H,15,27,30-31,33H2,1-11H3,(H2,58,59,60,63,64)/t46-,48-,49-,53-,75?/m1/s1

Synonyms: N2-isobutyryl-5'-O-4,4'-(dimethoxytrityl)-2'-O-(2,4,6-trimethoxybenzylthiomethyl)-guanosine-3'-cyanoethyl Phosphoramidite

5'-O-DMTr-2'-O-TMBTM-U-3'-CE-Phosphoramidite

Description: This phosphoramidite introduces a uridine nucleoside where the 2'-hydroxyl group is modified with a TMBTM group and protected with a DMTr group at the 5'-position. It is modified with a uracil base at the 3'-position and protected with a CE group. Modifications like these are useful in RNA research to study RNA-protein interactions and enzymatic processes.

CAT: BRP-01128

CAS: 1449578-46-4

MF: C50H61N4O12PS

MF: 973.09

Purity: ≥97% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: JNQQDMGQFJAHSP-NCVHJKQYSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OCSCC2=C(C=C(C=C2OC)OC)OC)N3C=CC(=O)NC3=O)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(2,4-dioxopyrimidin-1-yl)-4-[(2,4,6-trimethoxyphenyl)methylsulfanylmethoxy]oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C50H61N4O12PS/c1-33(2)54(34(3)4)67(64-27-13-25-51)66-46-44(30-63-50(35-14-11-10-12-15-35,36-16-20-38(57-5)21-17-36)37-18-22-39(58-6)23-19-37)65-48(53-26-24-45(55)52-49(53)56)47(46)62-32-68-31-41-42(60-8)28-40(59-7)29-43(41)61-9/h10-12,14-24,26,28-29,33-34,44,46-48H,13,27,30-32H2,1-9H3,(H,52,55,56)/t44-,46-,47-,48-,67?/m1/s1

Synonyms: 5'-O-(4,4'-dimethoxytrityl)-2'-O-(2,4,6-trimethoxybenzylthiomethyl)-uridine-3'-cyanoethyl Phosphoramidite; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[[[(2,4,6-trimethoxyphenyl)methyl]thio]methyl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

5'-O-DMTr-2'-O-Trifluoroacetamido propyl-U-3'-CE-Phosphoramidite

Description: This phosphoramidite introduces a uridine nucleoside where the 2'-hydroxyl group is modified with a trifluoroacetamido propyl group and protected with a DMTr group at the 5'-position. It is protected with a CE group at the 3'-position. Such modifications can alter RNA stability and interactions with other molecules in biochemical studies.

CAT: BRP-01129

CAS: 165381-49-7

MF: C44H53F3N5O10P

MF: 899.90

Purity: ≥97% by UPLC

Appearance: White, off-white to light yellow powder

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InChIKey: JDBCEYQBKYYZNE-OVLVZACUSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OCCCNC(=O)C(F)(F)F)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: N-[3-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-2-(2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxypropyl]-2,2,2-trifluoroacetamide

InChI: InChI=1S/C44H53F3N5O10P/c1-29(2)52(30(3)4)63(60-27-10-23-48)62-38-36(61-40(51-25-22-37(53)50-42(51)55)39(38)58-26-11-24-49-41(54)44(45,46)47)28-59-43(31-12-8-7-9-13-31,32-14-18-34(56-5)19-15-32)33-16-20-35(57-6)21-17-33/h7-9,12-22,25,29-30,36,38-40H,10-11,24,26-28H2,1-6H3,(H,49,54)(H,50,53,55)/t36-,38-,39-,40-,63?/m1/s1

Synonyms: 5'-O-(4,4'-Dimethoxytrityl)-2'-O-trifluoroacetamido propyl-uridine-3'-[(2-cyanoethyl)-(N,N-diisopropropyl)]-Phosphoramidite; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[3-[(trifluoroacetyl)amino]propyl]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; 2'-O-Trifluoroacetamido propyl Uridine CED phosphoramidite

5'-O-DMTr-2'-O-Trifluoroacetamindo propyl-G(iBu)-3'-CE-Phosphoramidite

Description: This phosphoramidite introduces a guanosine nucleoside where the 2'-hydroxyl group is modified with a trifluoroacetamido propyl group and protected with a DMTr group at the 5'-position. It is modified with an isobutyryl (iBu) group at the 3'-position and protected with a CE group. Modifications like these can enhance RNA binding affinity and stability.

CAT: BRP-01130

MF: C49H60F3N8O10P

MF: 1009.03

Purity: ≥97% by UPLC

Appearance: White, off-white to light yellow powder

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InChIKey: HSHKDSSCDQGICM-WYWHGLPISA-N

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N(C(C)C)C(C)C)OCCC#N)OCCCNC(=O)C(F)(F)F

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-[3-[(2,2,2-trifluoroacetyl)amino]propoxy]oxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide

InChI: InChI=1S/C49H60F3N8O10P/c1-30(2)43(61)57-47-56-42-39(44(62)58-47)55-29-59(42)45-41(66-26-13-25-54-46(63)49(50,51)52)40(70-71(68-27-12-24-53)60(31(3)4)32(5)6)38(69-45)28-67-48(33-14-10-9-11-15-33,34-16-20-36(64-7)21-17-34)35-18-22-37(65-8)23-19-35/h9-11,14-23,29-32,38,40-41,45H,12-13,25-28H2,1-8H3,(H,54,63)(H2,56,57,58,61,62)/t38-,40-,41-,45-,71?/m1/s1

Synonyms: N2-isobutyryl-5'-O-(4,4'-Dimethoxytrityl)-2'-O-trifluoroacetamido propyl-guanosine-3'-[(2-cyanoethyl)-(N,N-diisopropropyl)]-Phosphoramidite; (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(3-(2,2,2-trifluoroacetamido)propoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

5'-O-DMTr-2'-O-Trifluoroacetamindo propyl-C(Bz)-3'-CE-Phosphoramidite

Description: This phosphoramidite introduces a cytidine nucleoside where the 2'-hydroxyl group is modified with a trifluoroacetamido propyl group and protected with a DMTr group at the 5'-position. It is modified with a benzoyl (Bz) group at the 3'-position and protected with a CE group. Such modifications can influence RNA structure and function in biochemical and therapeutic applications.

CAT: BRP-01131

CAS: 165381-54-4

MF: C51H58F3N6O10P

MF: 1003.03

Purity: ≥97% by UPLC

Appearance: White, off-white to light yellow powder

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InChIKey: PLGRAOCWBZAGHT-YJGWTFTBSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OCCCNC(=O)C(F)(F)F)N2C=CC(=NC2=O)NC(=O)C3=CC=CC=C3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-[3-[(2,2,2-trifluoroacetyl)amino]propoxy]oxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide

InChI: InChI=1S/C51H58F3N6O10P/c1-34(2)60(35(3)4)71(68-32-13-28-55)70-44-42(33-67-50(37-17-11-8-12-18-37,38-19-23-40(64-5)24-20-38)39-21-25-41(65-6)26-22-39)69-47(45(44)66-31-14-29-56-48(62)51(52,53)54)59-30-27-43(58-49(59)63)57-46(61)36-15-9-7-10-16-36/h7-12,15-27,30,34-35,42,44-45,47H,13-14,29,31-33H2,1-6H3,(H,56,62)(H,57,58,61,63)/t42-,44-,45-,47-,71?/m1/s1

Synonyms: N4-benzoyl-5'-O-(4,4'-Dimethoxytrityl)-2'-O-trifluoroacetamido propyl-cytidine-3'-[(2-cyanoethyl)-(N,N-diisopropropyl)]-Phosphoramidite; N4-Benzoyl-5'-O-DMTr-2'-O-(N3-trifluoroacetyl)cytidine 3'-CE-Phosphoramidite; Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[3-[(trifluoroacetyl)amino]propyl]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; 2'-O-Trifluoroacetamido propyl Cytidine CED phosphoramidite

5'-O-DMTr-2'-O-Trifluoroacetamindo propyl-A(Bz)-3'-CE-Phosphoramidite

Description: This phosphoramidite introduces an adenosine nucleoside where the 2'-hydroxyl group is modified with a trifluoroacetamido propyl group and protected with a DMTr group at the 5'-position. It is modified with a benzoyl (Bz) group at the 3'-position and protected with a CE group. Modifications like these are important for RNA research, enabling the study of RNA structure and function in various biological contexts.

CAT: BRP-01132

MF: C52H58F3N8O9P

MF: 1027.05

Purity: ≥97% by UPLC

Appearance: White, off-white to light yellow powder

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InChIKey: FDFXBSKFDLJDCP-DTABEXQVSA-N

IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(3-(2,2,2-trifluoroacetamido)propoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C52H58F3N8O9P/c1-34(2)63(35(3)4)73(70-30-13-27-56)72-44-42(31-69-51(37-17-11-8-12-18-37,38-19-23-40(66-5)24-20-38)39-21-25-41(67-6)26-22-39)71-49(45(44)68-29-14-28-57-50(65)52(53,54)55)62-33-60-43-46(58-32-59-47(43)62)61-48(64)36-15-9-7-10-16-36/h7-12,15-26,32-35,42,44-45,49H,13-14,28-31H2,1-6H3,(H,57,65)(H,58,59,61,64)/t42-,44-,45-,49-,73?/m1/s1

Synonyms: N6-benzoyl-5'-O-(4,4'-Dimethoxytrityl)-2'-O-trifluoroacetamido propyl-adenosine-3'-[(2-cyanoethyl)-(N,N-diisopropropyl)]-Phosphoramidite

5'-O-DMTr-2'-ara-OAc-I-3'-CE-Phosphoramidite

Description: This phosphoramidite introduces an inosine nucleoside where the 2'-hydroxyl group is modified with an arabinose acetyl (ara-OAc) group and protected with a DMTr group at the 5'-position. It is protected with a CE group at the 3'-position. Such modifications are used in RNA synthesis to study RNA modifications and their effects on RNA structure and function.

CAT: BRP-01133

CAS: 1449326-35-5

MF: C42H49N6O9P

MF: 812.86

Purity: ≥95% by HPLC

Appearance: Colorless to light yellow crystalline or white,off-white to light yellow amorphous dry powder

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InChIKey: LDSVRAQLSNCVSP-OOPWZCSESA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C(=O)N=CNC32)C1OC(=O)C)COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C

IUPAC Name: (2R,3S,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-2-(6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl acetate

InChI: InChI=1S/C42H49N6O9P/c1-27(2)48(28(3)4)58(54-23-11-22-43)57-37-35(56-41(38(37)55-29(5)49)47-26-46-36-39(47)44-25-45-40(36)50)24-53-42(30-12-9-8-10-13-30,31-14-18-33(51-6)19-15-31)32-16-20-34(52-7)21-17-32/h8-10,12-21,25-28,35,37-38,41H,11,23-24H2,1-7H3,(H,44,45,50)/t35-,37-,38+,41-,58?/m1/s1

Synonyms: 5'-O-(4,4'-dimethoxytrityl)-2'-O-actyl-arabinoinosine-3'-[(2-cyanoethyl)-(N,N-diisopropropyl)]-Phosphoramidite; 9-[2-O-Acetyl-5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-β-D-arabinofuranosyl]-1,9-dihydro-6H-purin-6-one

5'-O-DMTr-2'-ara-OMe-I-3'-CE-Phosphoramidite

Description: This phosphoramidite introduces an inosine nucleoside where the 2'-hydroxyl group is modified with an arabinose methyl (ara-OMe) group and protected with a DMTr group at the 5'-position. It is protected with a CE group at the 3'-position. Modifications like these are utilized in RNA research to investigate RNA modifications and their roles in gene expression and disease mechanisms.

CAT: BRP-01134

MF: C41H49N6O8P

MF: 784.85

Purity: ≥95% by HPLC

Appearance: Colorless to light yellow crystalline or white,off-white to light yellow amorphous dry powder

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InChIKey: PVFNTYBGWVZMCX-LSYABVRWSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C(=O)N=CNC32)C1OC)COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxy-5-(6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C41H49N6O8P/c1-27(2)47(28(3)4)56(53-23-11-22-42)55-36-34(54-40(37(36)51-7)46-26-45-35-38(46)43-25-44-39(35)48)24-52-41(29-12-9-8-10-13-29,30-14-18-32(49-5)19-15-30)31-16-20-33(50-6)21-17-31/h8-10,12-21,25-28,34,36-37,40H,11,23-24H2,1-7H3,(H,43,44,48)/t34-,36-,37+,40-,56?/m1/s1

Synonyms: 5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-arabinoinosine-3'-[(2-cyanoethyl)-(N,N-diisopropropyl)]-Phosphoramidite; Arainosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

[5'-O-DMTr-2'-OMe-C(Ac)](P-thio-pCyEt)[2'-O-Me-C(Ac)-3'-CE-Phosphoramidite]

Description: [5'-O-DMTr-2'-OMe-C(Ac)](P-thio-pCyEt)[2'-O-Me-C(Ac)-3'-CE-Phosphoramidite] is a chemically modified nucleoside phosphoramidite used in the synthesis of stable and resistant oligonucleotides. The modifications, including the 2'-O-methyl, phosphorothioate, and various protecting groups, enhance the stability, binding affinity, and resistance to degradation of the resulting oligonucleotides. This makes it a valuable tool in biochemical research and therapeutic development.

CAT: BRP-01135

MF: C57H71N9O16P2S

MF: 1232.25

Purity: ≥95% by HPLC

Appearance: White, off-white to light yellow powder

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InChIKey: DZYQPLFPNVDNBI-OERPVMKOSA-N

IUPAC Name: (2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((((((2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphorothioyl)oxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C57H71N9O16P2S/c1-36(2)66(37(3)4)83(76-32-14-28-58)81-49-46(80-53(51(49)73-9)64-30-26-47(60-38(5)67)62-55(64)69)35-78-84(85,77-33-15-29-59)82-50-45(79-54(52(50)74-10)65-31-27-48(61-39(6)68)63-56(65)70)34-75-57(40-16-12-11-13-17-40,41-18-22-43(71-7)23-19-41)42-20-24-44(72-8)25-21-42/h11-13,16-27,30-31,36-37,45-46,49-54H,14-15,32-35H2,1-10H3,(H,60,62,67,69)(H,61,63,68,70)/t45-,46-,49-,50-,51-,52-,53-,54-,83?,84?/m1/s1

Synonyms: [5'-O-DMTr-2'-O-Me-C(Ac)](P-thio-pCyEt)[2'-O-Me-C(Ac)-3'-CE-Phosphoramidite

DMO-4AG-N,N-dimethyl phosphoramidochloridate

Description: DMO-4AG-N,N-dimethyl phosphoramidochloridate is a reagent used in oligonucleotide synthesis, featuring a 4-amino group on the nucleobase and a dimethyl phosphoramidochloridate group. This reagent facilitates the introduction of specific phosphoramidite functionalities, enhancing the stability and binding affinity of the synthesized oligonucleotides.

CAT: BRP-01136

MF: C62H68ClN15O11P2

MF: 1296.72

Purity: ≥98% by HPLC

Appearance: White, off-white to light yellow powder

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InChIKey: JLONTSADQKXEQI-PIVCNVESSA-N

IUPAC Name: ((2S,6R)-6-(6-benzamido-9H-purin-9-yl)-4-((dimethylamino)(((2S,6R)-6-(2-isobutyramido-6-(4-nitrophenethoxy)-9H-purin-9-yl)-4-tritylmorpholin-2-yl)methoxy)phosphoryl)morpholin-2-yl)methyl dimethylphosphoramidochloridate

InChI: InChI=1S/C62H68ClN15O11P2/c1-42(2)58(79)70-61-69-57-54(60(71-61)85-32-31-43-27-29-48(30-28-43)78(81)82)67-41-77(57)51-35-74(62(45-21-13-8-14-22-45,46-23-15-9-16-24-46)47-25-17-10-18-26-47)33-49(88-51)38-87-91(84,73(5)6)75-34-50(37-86-90(63,83)72(3)4)89-52(36-75)76-40-66-53-55(64-39-65-56(53)76)68-59(80)44-19-11-7-12-20-44/h7-30,39-42,49-52H,31-38H2,1-6H3,(H,64,65,68,80)(H,69,70,71,79)/t49-,50-,51+,52+,90?,91?/m0/s1

Synonyms: DMO-4AG-N,N-dimethyl phosphoramidochloridate