Phosphoramidites

1-O-DMTr-Glycerol-TEG-Cholesterol-2-CE-Phosphoramidite

Description: This complex phosphoramidite derivative is used in solid-phase synthesis to introduce a glycerol-TEG-cholesterol linker with a 2-cyanoethyl (2-CE) protecting group at the 2' position of ribose. It is employed to modify oligonucleotides for enhanced stability, cellular uptake, or targeted delivery in gene therapy and drug development.

CAT: BRP-01107

Molecular Formula: C68H103N2O10P

Molecular Weight: 1139.55

Purity: ≥98% by HPLC

Appearance: Colorless to faint yellow oily matter

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InChIKey: ICUVMFZDOBVYKJ-JVGOCSKKSA-N

IUPAC Name: 2-cyanoethyl (17-(((3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)-1,1-bis(4-methoxyphenyl)-1-phenyl-2,6,9,12,15-pentaoxaheptadecan-4-yl) diisopropylphosphoramidite

InChI: InChI=1S/C68H103N2O10P/c1-50(2)17-15-18-53(7)63-31-32-64-62-30-25-57-47-60(33-35-66(57,8)65(62)34-36-67(63,64)9)77-46-45-75-42-41-73-39-40-74-43-44-76-48-61(80-81(79-38-16-37-69)70(51(3)4)52(5)6)49-78-68(54-19-13-12-14-20-54,55-21-26-58(71-10)27-22-55)56-23-28-59(72-11)29-24-56/h12-14,19-29,50-53,60-65H,15-18,30-36,38-49H2,1-11H3/t53-,60+,61?,62+,63-,64+,65+,66+,67-,81?/m1/s1

Synonyms: 1-O-(4,4'-dimethoxytrityl)-Glycerol-Triethyleneglycol-Cholesterol-2-Cyanoethyl Phosphoramidite; Cholesteryl amidite (plant source); Cholesteryl amidite

TEG Linker2

Description: TEG Linker2 refers to a second-generation triethylene glycol linker. It is utilized in bioconjugation chemistry to attach biomolecules to surfaces or to modify their physicochemical properties, improving their solubility and stability in various biological environments.

CAT: BRP-01108

CAS: 3030325-67-5

Molecular Formula: C33H45NO8

Molecular Weight: 583.71

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Density: 1.139±0.06 g/cm3

Boiling Point: 701.6±60.0 °C at 760 mmHg

InChIKey: XNEDRVJRLFZTIK-UHFFFAOYSA-N

CanonicalSMILES: COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)OCC(COCCOCCOCCOCCCN)O

IUPAC Name: 1-[2-[2-[2-(3-aminopropoxy)ethoxy]ethoxy]ethoxy]-3-[bis(4-methoxyphenyl)-phenylmethoxy]propan-2-ol

InChI: InChI=1S/C33H45NO8/c1-36-31-13-9-28(10-14-31)33(27-7-4-3-5-8-27,29-11-15-32(37-2)16-12-29)42-26-30(35)25-41-24-23-40-22-21-39-20-19-38-18-6-17-34/h3-5,7-16,30,35H,6,17-26,34H2,1-2H3

Synonyms: 16-amino-1-O-(4,4'-dimethoxytrityl)-4,7,10,13-tetraoxahexadecan-1,2-diol; 18-amino-1,1-bis(4-methoxyphenyl)-1-phenyl-2,6,9,12,15-pentaoxaoctadecan-4-ol; 2-Propanol, 1-[2-[2-[2-(3-aminopropoxy)ethoxy]ethoxy]ethoxy]-3-[bis(4-methoxyphenyl)phenylmethoxy]-

6-O-DMTr-hexane-bis-(diisopropylamino)-Phosphane

Description: This compound is a phosphoramidite derivative used in oligonucleotide synthesis. It features a hexane-bis-(diisopropylamino) phosphane group protected with a dimethoxytrityl (DMTr) group at the 6-position. It facilitates controlled and efficient coupling of oligonucleotides during solid-phase synthesis, ensuring high yields and purity of the final products.

CAT: BRP-01110

Molecular Formula: C39H59N2O4P

Molecular Weight: 650.88

Purity: ≥97% by HPLC

Appearance: Colorless to light yellow oily matter

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InChIKey: VJKCRNMYXQZNIK-UHFFFAOYSA-N

CanonicalSMILES: CC(N(P(OCCCCCCOC(C1=CC=CC=C1)(C(C=C2)=CC=C2OC)C(C=C3)=CC=C3OC)N(C(C)C)C(C)C)C(C)C)C

IUPAC Name: 1-((6-(bis(4-methoxyphenyl)(phenyl)methoxy)hexyl)oxy)-N,N,N',N'-tetraisopropylphosphanediamine

InChI: InChI=1S/C39H59N2O4P/c1-30(2)40(31(3)4)46(41(32(5)6)33(7)8)45-29-17-12-11-16-28-44-39(34-18-14-13-15-19-34,35-20-24-37(42-9)25-21-35)36-22-26-38(43-10)27-23-36/h13-15,18-27,30-33H,11-12,16-17,28-29H2,1-10H3

Synonyms: 6-O-(4,4'-dimethoxytrityl)-hexane-bis-(diisopropylamino)-Phosphane

5'-O-DMTr-2'-O-(methoxycarbonyl)methyl-G(iBu)-3'-CE-Phosphoramidite

Description: This phosphoramidite derivative introduces a modified guanosine nucleoside where the 2'-hydroxyl group is protected with a methoxycarbonyl methyl group (OMeCOOMe). It is protected at the 5'-position with a dimethoxytrityl (DMTr) group and at the 3'-position with a cyanoethyl (CE) group. This modification can stabilize RNA structures, alter enzymatic properties, or enhance binding affinity in biochemical and therapeutic applications.

CAT: BRP-01111

Molecular Formula: C47H58N7O11P

Molecular Weight: 927.99

Purity: ≥98% by UPLC

Appearance: White, off-white to light yellow powder

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InChIKey: IJABPRIFTVFZJB-NCJSJSGWSA-N

IUPAC Name: methyl 2-(((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-2-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl)oxy)acetate

InChI: InChI=1S/C47H58N7O11P/c1-29(2)43(56)51-46-50-42-39(44(57)52-46)49-28-53(42)45-41(61-27-38(55)60-9)40(65-66(63-25-13-24-48)54(30(3)4)31(5)6)37(64-45)26-62-47(32-14-11-10-12-15-32,33-16-20-35(58-7)21-17-33)34-18-22-36(59-8)23-19-34/h10-12,14-23,28-31,37,40-41,45H,13,25-27H2,1-9H3,(H2,50,51,52,56,57)/t37-,40-,41-,45-,66?/m1/s1

Synonyms: N6-benzoyl-5'-O-(4,4'-Dimethoxytrityl)-2'-O-(methoxycarbonyl)methyl-guanosine-3'-[(2-cyanoethyl)-(N,N-diisopropropyl)]-Phosphoramidite

5'-O-DMTr-2'-O-(methoxycarbonyl)methyl-5-Me-C(iBu)-3'-CE-Phosphoramidite

Description: This phosphoramidite introduces a modified 5-methylcytidine nucleoside where the 2'-hydroxyl group is protected with a methoxycarbonyl methyl group (OMeCOOMe). It is protected at the 5'-position with a DMTr group and at the 3'-position with a CE group. This modification is useful for studying RNA stability, protein binding, and enzymatic activity.

CAT: BRP-01112

Molecular Formula: C47H60N5O11P

Molecular Weight: 901.99

Purity: ≥98% by UPLC

Appearance: White, off-white to light yellow powder

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InChIKey: GLHSMORVQTYUKD-LKYMEUIMSA-N

IUPAC Name: methyl 2-(((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-2-(4-isobutyramido-5-methyl-2-oxopyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)oxy)acetate

InChI: InChI=1S/C47H60N5O11P/c1-30(2)44(54)49-43-33(7)27-51(46(55)50-43)45-42(59-29-40(53)58-10)41(63-64(61-26-14-25-48)52(31(3)4)32(5)6)39(62-45)28-60-47(34-15-12-11-13-16-34,35-17-21-37(56-8)22-18-35)36-19-23-38(57-9)24-20-36/h11-13,15-24,27,30-32,39,41-42,45H,14,26,28-29H2,1-10H3,(H,49,50,54,55)/t39-,41-,42-,45-,64?/m1/s1

Synonyms: N6-benzoyl-5'-O-(4,4'-Dimethoxytrityl)-2'-O-(methoxycarbonyl)methyl-5-methyl-cytidine-3'-[(2-cyanoethyl)-(N,N-diisopropropyl)]-Phosphoramidite

5'-O-DMTr-2'-O-(methoxycarbonyl)methyl-5-Me-U-3'-CE-Phosphoramidite

Description: This phosphoramidite introduces a modified 5-methyluridine nucleoside where the 2'-hydroxyl group is protected with a methoxycarbonyl methyl group (OMeCOOMe). It is protected at the 5'-position with a DMTr group and at the 3'-position with a CE group. Modifications like this can influence RNA structure and function, impacting gene expression and regulatory mechanisms.

CAT: BRP-01113

CAS: 304442-34-0

Molecular Formula: C43H53N4O11P

Molecular Weight: 832.89

Purity: ≥98% by UPLC

Appearance: White, off-white to light yellow powder

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InChIKey: CYKHRNSJKAITPH-FMMLDEGOSA-N

CanonicalSMILES: CC1=CN(C(=O)NC1=O)C2C(C(C(O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OP(N(C(C)C)C(C)C)OCCC#N)OCC(=O)OC

IUPAC Name: methyl 2-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-2-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxyacetate

InChI: InChI=1S/C43H53N4O11P/c1-28(2)47(29(3)4)59(56-24-12-23-44)58-38-36(57-41(39(38)54-27-37(48)53-8)46-25-30(5)40(49)45-42(46)50)26-55-43(31-13-10-9-11-14-31,32-15-19-34(51-6)20-16-32)33-17-21-35(52-7)22-18-33/h9-11,13-22,25,28-29,36,38-39,41H,12,24,26-27H2,1-8H3,(H,45,49,50)/t36-,38-,39-,41-,59?/m1/s1

Synonyms: N6-benzoyl-5'-O-(4,4'-Dimethoxytrityl)-2'-O-(methoxycarbonyl)methyl-5-methyl-uridine-3'-[(2-cyanoethyl)-(N,N-diisopropropyl)]-Phosphoramidite; methyl 2-(((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)oxy)acetate; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxy-2-oxoethyl)-5-methyl-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

5'-O-DMTr-2'-O-(methoxycarbonyl)methyl-A(Bz)-3'-CE-Phosphoramidite

Description: This phosphoramidite introduces a modified adenosine nucleoside where the 2'-hydroxyl group is protected with a methoxycarbonyl methyl group (OMeCOOMe). It is protected at the 5'-position with a DMTr group and at the 3'-position with a CE group. Such modifications are crucial for designing RNA molecules with specific structural or functional properties in research and therapeutic applications.

CAT: BRP-01114

CAS: 329279-48-3

Molecular Formula: C50H56N7O10P

Molecular Weight: 946.01

Purity: ≥98% by UPLC

Appearance: White, off-white to light yellow powder

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InChIKey: BHOZQFFADFBWRN-GNUXOQNYSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OCC(=O)OC)N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC

IUPAC Name: methyl 2-[(2R,3R,4R,5R)-2-(6-benzamidopurin-9-yl)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-3-yl]oxyacetate

InChI: InChI=1S/C50H56N7O10P/c1-33(2)57(34(3)4)68(65-28-14-27-51)67-44-41(29-64-50(36-17-12-9-13-18-36,37-19-23-39(60-5)24-20-37)38-21-25-40(61-6)26-22-38)66-49(45(44)63-30-42(58)62-7)56-32-54-43-46(52-31-53-47(43)56)55-48(59)35-15-10-8-11-16-35/h8-13,15-26,31-34,41,44-45,49H,14,28-30H2,1-7H3,(H,52,53,55,59)/t41-,44-,45-,49-,68?/m1/s1

Synonyms: N6-benzoyl-5'-O-(4,4'-Dimethoxytrityl)-2'-O-(methoxycarbonyl)methyl-adenosine-3'-[(2-cyanoethyl)-(N,N-diisopropropyl)]-Phosphoramidite; Methyl 2-(((2R,3R,4R,5R)-2-(6-benzamido-9H-purin-9-yl)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)tetrahydrofuran-3-yl)oxy)acetate; Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxy-2-oxoethyl)-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

5'-O-DMTr-2'-O-Me-8-Me-G(dmf)-3'-CE Phosphoramidite

Description: This phosphoramidite introduces an 8-methylguanosine nucleoside where the 2'-hydroxyl group is protected with a methyl group. It is protected at the 5'-position with a DMTr group and at the 3'-position with a CE group. Modifications like 8-methylguanosine can alter RNA stability, folding, and interactions with proteins or small molecules, impacting biological processes.

CAT: BRP-01115

Molecular Formula: C45H57N8O8P

Molecular Weight: 868.97

Purity: ≥97% by UPLC

Appearance: White, off-white to light yellow powder

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InChIKey: IJFUVMLFBVVNDL-GDLAVZMWSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-(((dimethylamino)methylene)amino)-8-methyl-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C45H57N8O8P/c1-29(2)53(30(3)4)62(59-26-14-25-46)61-39-37(60-43(40(39)57-10)52-31(5)48-38-41(52)49-44(50-42(38)54)47-28-51(6)7)27-58-45(32-15-12-11-13-16-32,33-17-21-35(55-8)22-18-33)34-19-23-36(56-9)24-20-34/h11-13,15-24,28-30,37,39-40,43H,14,26-27H2,1-10H3,(H,49,50,54)/t37-,39-,40-,43-,62?/m1/s1

Synonyms: N2-dimethylformamide-8-methyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-guanosine-3'-cyanoethyl Phosphoramidite

5'-O-DMTr-7-deaza-2'-O-Me-G(iBu)-3'-CE-Phosphoramidite

Description: 5'-O-DMTr-7-deaza-2'-O-Me-G(iBu)-3'-CE-Phosphoramidite is a phosphoramidite utilized in oligonucleotide synthesis. It incorporates a modified form of guanosine into nucleic acid sequences, featuring a 7-deaza substitution, a methyl group at the 2'-position of the ribose sugar, and an isobutyryl protecting group on the guanosine base. Additionally, it contains a cyanoethyl protecting group at the 3'-position to aid in solid-phase synthesis. This compound enables controlled synthesis of modified oligonucleotides for various molecular biology applications.

CAT: BRP-01116

Molecular Formula: C46H57N6O9P

Molecular Weight: 868.97

Purity: ≥98% by HPLC

Appearance: White to off-white powder

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InChIKey: BKKPILOQLJDDRS-BFXDPCJQSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C46H57N6O9P/c1-29(2)42(53)49-45-48-41-37(43(54)50-45)24-26-51(41)44-40(57-9)39(61-62(59-27-13-25-47)52(30(3)4)31(5)6)38(60-44)28-58-46(32-14-11-10-12-15-32,33-16-20-35(55-7)21-17-33)34-18-22-36(56-8)23-19-34/h10-12,14-24,26,29-31,38-40,44H,13,27-28H2,1-9H3,(H2,48,49,50,53,54)/t38-,39-,40-,44-,62?/m1/s1

Synonyms: N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-7-deaza-2'-O-methyl-guanosine-3'-cyanoethyl Phosphoramidite; 7-deaza-2'-O-Methyl Guanosine CED phosphoramidite; 7-deaza 2'-O-Methyl G(iBu) 3'-CE phosphoramidite

O6-Protected-5'-DMT-2'-OMe-G(iBu)-CE-Phosphoramidite

Description: This phosphoramidite derivative introduces a guanosine nucleoside modified with a 2'-OMe group (2'-O-methyl) and protected at the O6 position with a specific protecting group. It is protected at the 5'-position with a dimethoxytrityl (DMT) group and at the 3'-position with a cyanoethyl (CE) group. Such modifications are crucial for studying RNA structure and function, including RNA stability and interactions with proteins or small molecules.

CAT: BRP-01117

Molecular Formula: C57H70N7O11P

Molecular Weight: 1060.18

Purity: ≥98% by HPLC

Appearance: White to off-white powder

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InChIKey: NZGAIHSRQZRTST-VQLBZFODSA-N

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=N1)OCC3=CC=C(C=C3)OC(=O)C(C)(C)C)N=CN2C4C(C(C(O4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC)OP(N(C(C)C)C(C)C)OCCC#N)OC

IUPAC Name: [4-[[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-methoxyoxolan-2-yl]-2-(2-methylpropanoylamino)purin-6-yl]oxymethyl]phenyl] 2,2-dimethylpropanoate

InChI: InChI=1S/C57H70N7O11P/c1-36(2)51(65)61-55-60-50-47(52(62-55)70-33-39-19-25-45(26-20-39)73-54(66)56(7,8)9)59-35-63(50)53-49(69-12)48(75-76(72-32-16-31-58)64(37(3)4)38(5)6)46(74-53)34-71-57(40-17-14-13-15-18-40,41-21-27-43(67-10)28-22-41)42-23-29-44(68-11)30-24-42/h13-15,17-30,35-38,46,48-49,53H,16,32-34H2,1-12H3,(H,60,61,62,65)/t46-,48-,49-,53-,76?/m1/s1

Synonyms: O6-(p-Tolyl pivalate)-N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-guanosine-3'-cyanoethyl phosphoramidite; 4-(((9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-3-methoxytetrahydrofuran-2-yl)-2-isobutyramido-9H-purin-6-yl)oxy)methyl)phenyl pivalate; O6-(p-Tolyl pivalate)-5'-DMT-2'-OMe-G(iBu)-CE-Phosphoramidite

DMT-1'-urea-2'-O-Me Amidite

Description: This amidite derivative is used in solid-phase synthesis to introduce a modified nucleoside where the 2'-hydroxyl group is protected with a methyl group (2'-O-methyl) and the 1'-position is protected with a urea moiety. This modification can stabilize RNA structures and enhance binding affinity in biochemical and therapeutic applications.

CAT: BRP-01118

Molecular Formula: C37H49N4O8P

Molecular Weight: 708.79

Purity: ≥95% by HPLC

Appearance: White to off-white powder

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InChIKey: CHPGSEHZXRWFRA-JZDAHGDVSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(NC(=O)N)C1OC)COC(C=2C=CC=CC2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxy-5-ureidotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C37H49N4O8P/c1-25(2)41(26(3)4)50(47-23-11-22-38)49-33-32(48-35(34(33)45-7)40-36(39)42)24-46-37(27-12-9-8-10-13-27,28-14-18-30(43-5)19-15-28)29-16-20-31(44-6)21-17-29/h8-10,12-21,25-26,32-35H,11,23-24H2,1-7H3,(H3,39,40,42)/t32-,33-,34-,35-,50?/m1/s1

Synonyms: 5'-O-(4,4'-Dimethoxytrityl)-1'-urea-2'-O-methyl phosphoramidite

5'-BzH-2'-OMe-Ur-3'-Methoxyphosphoramidite

Description: This phosphoramidite introduces a uridine nucleoside modified with a benzoylhydrazine (BzH) group at the 5'-position, a 2'-O-methyl group, and protected at the 3'-position with a methoxy group. Such modifications are used in RNA research to study RNA-protein interactions, RNA stability, and enzymatic processes.

CAT: BRP-01119

Molecular Formula: C36H58N3O10PSi3

Molecular Weight: 808.09

Purity: ≥97% by HPLC

Appearance: Colorless or faint yellow oily matter

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InChIKey: CDIAPRHBHZFMSI-UZMHDONASA-N

IUPAC Name: (2R,3R,4R,5R)-2-(((3-(benzhydryloxy)-1,1,1,5,5,5-hexamethyltrisiloxan-3-yl)oxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl methyl diisopropylphosphoramidite

InChI: InChI=1S/C36H58N3O10PSi3/c1-26(2)39(27(3)4)50(43-6)46-33-30(45-35(34(33)42-5)38-24-23-31(40)37-36(38)41)25-44-53(48-51(7,8)9,49-52(10,11)12)47-32(28-19-15-13-16-20-28)29-21-17-14-18-22-29/h13-24,26-27,30,32-35H,25H2,1-12H3,(H,37,40,41)/t30-,33-,34-,35-,50?/m1/s1

Synonyms: 5'-BzH-2'-O-methyl-Uridine-3'-Methoxyphosphoramidite

5'-BzH-2'-OMe-Ac-Cr-3'-Methoxyphosphoramidite

Description: This phosphoramidite introduces an adenosine nucleoside modified with a benzoylhydrazine (BzH) group at the 5'-position, a 2'-O-methyl group, an acetyl group, and protected at the 3'-position with a methoxy group. Modifications like these are employed in RNA chemical biology to probe RNA structure and function, as well as for therapeutic applications.

CAT: BRP-01120

Molecular Formula: C38H61N4O10PSi3

Molecular Weight: 849.14

Purity: ≥97% by HPLC

Appearance: Colorless or faint yellow oily matter

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InChIKey: UYPJICYBURNHSL-MCXUBDGSSA-N

IUPAC Name: (2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-(((3-(benzhydryloxy)-1,1,1,5,5,5-hexamethyltrisiloxan-3-yl)oxy)methyl)-4-methoxytetrahydrofuran-3-yl methyl diisopropylphosphoramidite

InChI: InChI=1S/C38H61N4O10PSi3/c1-27(2)42(28(3)4)53(46-7)49-35-32(48-37(36(35)45-6)41-25-24-33(39-29(5)43)40-38(41)44)26-47-56(51-54(8,9)10,52-55(11,12)13)50-34(30-20-16-14-17-21-30)31-22-18-15-19-23-31/h14-25,27-28,32,34-37H,26H2,1-13H3,(H,39,40,43,44)/t32-,35-,36-,37-,53?/m1/s1

Synonyms: 5'-BzH-2'-O-methyl-Ac-Cytidine-3'-Methoxyphosphoramidite

O4-(p-tolyl pivalate)-5'-DMT-2'-OMe-U Phosphoramidite

Description: This phosphoramidite derivative introduces a uridine nucleoside modified at the O4 position with a p-tolyl pivalate group, protected at the 5'-position with a dimethoxytrityl (DMT) group, and at the 2'-position with a methyl group (2'-O-methyl). This modification can alter RNA structure and stability, influencing interactions with RNA-binding proteins and small molecules.

CAT: BRP-01121

Molecular Formula: C52H63N4O11P

Molecular Weight: 951.05

Purity: ≥98% by HPLC

Appearance: White to off-white powder

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InChIKey: PJMYGKOZFBVJOS-WLKQIKNLSA-N

IUPAC Name: 4-(((1-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-3-methoxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)oxy)methyl)phenyl pivalate

InChI: InChI=1S/C52H63N4O11P/c1-35(2)56(36(3)4)68(64-32-14-30-53)67-46-44(34-63-52(38-15-12-11-13-16-38,39-19-25-41(59-8)26-20-39)40-21-27-42(60-9)28-22-40)66-48(47(46)61-10)55-31-29-45(54-50(55)58)62-33-37-17-23-43(24-18-37)65-49(57)51(5,6)7/h11-13,15-29,31,35-36,44,46-48H,14,32-34H2,1-10H3/t44-,46-,47-,48-,68?/m1/s1

Synonyms: O4-(p-tolyl pivalate)-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-uridine-3'-cyanoethyl Phosphoramidite

Abasic MOE amidite (α,β mix)

Description: This amidite derivative introduces an abasic site mimic using a methoxyethyl (MOE) group, where the α and β anomeric forms are mixed. Abasic modifications are useful in RNA research to study the effects of missing bases on RNA structure and function.

CAT: BRP-01122

Molecular Formula: C44H65N2O9PSi

Molecular Weight: 825.05

Purity: ≥90% by HPLC

Appearance: Clear colorless to yellow oily matter

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InChIKey: OHGFRENWOYSROB-AQJVDKPMSA-N

IUPAC Name: (2R,3R,4R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-((tert-butyldimethylsilyl)oxy)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C44H65N2O9PSi/c1-32(2)46(33(3)4)56(52-28-16-27-45)54-40-39(53-42(41(40)50-30-29-47-8)55-57(11,12)43(5,6)7)31-51-44(34-17-14-13-15-18-34,35-19-23-37(48-9)24-20-35)36-21-25-38(49-10)26-22-36/h13-15,17-26,32-33,39-42H,16,28-31H2,1-12H3/t39-,40-,41-,42?,56?/m1/s1

Synonyms: Abasic MOE amidite (mixture of alpha and beta)

2,6-diamino(N2,N6-diiBu)-DMT-2'-O-MOE-purine riboside-CE-Phosphoramidite

Description: This phosphoramidite introduces a purine riboside nucleoside modified with 2,6-diamino groups at the N2 and N6 positions, protected with a dimethoxytrityl (DMT) group at the 5'-position, and a methoxyethyl (MOE) group at the 2'-position. Such modifications can enhance RNA binding affinity and stability, useful in RNA structure studies and therapeutic RNA design.

CAT: BRP-01123

Molecular Formula: C51H67N8O10P

Molecular Weight: 983.10

Purity: ≥90% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: NHUMZBQEINRZEF-RTHUGTBQSA-N

CanonicalSMILES: CC(C)C(=O)NC1=C2C(=NC(=N1)NC(=O)C(C)C)N(C=N2)C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N(C(C)C)C(C)C)OCCC#N)OCCOC

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-(2-methoxyethoxy)oxolan-2-yl]-2-(2-methylpropanoylamino)purin-6-yl]-2-methylpropanamide

InChI: InChI=1S/C51H67N8O10P/c1-32(2)47(60)54-45-42-46(56-50(55-45)57-48(61)33(3)4)58(31-53-42)49-44(65-29-28-62-9)43(69-70(67-27-15-26-52)59(34(5)6)35(7)8)41(68-49)30-66-51(36-16-13-12-14-17-36,37-18-22-39(63-10)23-19-37)38-20-24-40(64-11)25-21-38/h12-14,16-25,31-35,41,43-44,49H,15,27-30H2,1-11H3,(H2,54,55,56,57,60,61)/t41-,43-,44-,49-,70?/m1/s1

Synonyms: 2,6-diamino(N2,N6-diisobutyryl)-5'-O-(4,4'-Dimethoxytrityl)-2'-O-methoxyethyl-purine riboside-3'-cyanoethyl Phosphoramidite; (2R,3R,4R,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,6-diisobutyramido-9H-purin-9-yl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

5'-DMT-2'-O-NMA-5-Me-U-3'-CE-Phosphoramidite

Description: This phosphoramidite introduces a uridine nucleoside modified with a dimethoxytrityl (DMT) group at the 5'-position, a 2'-O-N-methylamino (NMA) group, and a methyl group at the 5-position, protected with a cyanoethyl (CE) group at the 3'-position. This modification can influence RNA structure and function, including RNA-protein interactions and stability.

CAT: BRP-01124

CAS: 1025783-16-7

Molecular Formula: C43H54N5O10P

Molecular Weight: 831.89

Purity: ≥98% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: FYNKMLIMLHVWST-FMMLDEGOSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=C(C(=O)NC2=O)C)C1OCC(=O)NC)COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-(2-(methylamino)-2-oxoethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C43H54N5O10P/c1-28(2)48(29(3)4)59(56-24-12-23-44)58-38-36(57-41(39(38)54-27-37(49)45-6)47-25-30(5)40(50)46-42(47)51)26-55-43(31-13-10-9-11-14-31,32-15-19-34(52-7)20-16-32)33-17-21-35(53-8)22-18-33/h9-11,13-22,25,28-29,36,38-39,41H,12,24,26-27H2,1-8H3,(H,45,49)(H,46,50,51)/t36-,38-,39-,41-,59?/m1/s1

Synonyms: [5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(methylamino)-2-oxoethyl]-5-methyluridine]-3'-[(2-cyanoethyl)-N,N-diisopropyl]phosphoramidite; 2'-O-NMA 5-Me-U amidite; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-5-methyl-2'-O-[2-(methylamino)-2-oxoethyl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

5'-O-DMTr-2'-O-TMBTM-A(Bz)-3'-CE-Phosphoramidite

Description: 5'-O-DMTr-2'-O-TMBTM-A(Bz)-3'-CE-Phosphoramidite is a modified adenine nucleoside phosphoramidite used in DNA and RNA synthesis. It features a DMTr (dimethoxytrityl) protecting group at the 5' position, a TMBTM (trimethoxybenzylthiomethyl) group at the 2' position, and a benzoyl-protected adenine base. This compound is essential for the synthesis of oligonucleotides with enhanced stability and functionality for use in genetic research and biotechnology.

CAT: BRP-01125

Molecular Formula: C58H66N7O11PS

Molecular Weight: 1100.24

Purity: ≥97% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: XJUICBHZUQLUOH-WMPDMCAKSA-N

IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2,4,6-trimethoxybenzyl)thio)methoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C58H66N7O11PS/c1-38(2)65(39(3)4)77(74-30-16-29-59)76-52-50(33-73-58(41-19-14-11-15-20-41,42-21-25-44(67-5)26-22-42)43-23-27-45(68-6)28-24-43)75-57(53(52)72-37-78-34-47-48(70-8)31-46(69-7)32-49(47)71-9)64-36-62-51-54(60-35-61-55(51)64)63-56(66)40-17-12-10-13-18-40/h10-15,17-28,31-32,35-36,38-39,50,52-53,57H,16,30,33-34,37H2,1-9H3,(H,60,61,63,66)/t50-,52-,53-,57-,77?/m1/s1

Synonyms: N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(2,4,6-trimethoxybenzylthiomethyl)-adenosine-3'-cyanoethyl Phosphoramidite

5'-O-DMTr-2'-O-TMBTM-C(Bz)-3'-CE-Phosphoramidite

Description: This phosphoramidite introduces a cytidine nucleoside where the 2'-hydroxyl group is modified with a TMBTM group and protected with a dimethoxytrityl (DMTr) group at the 5'-position. It is also modified with a benzoyl (Bz) group at the 3'-position and protected with a cyanoethyl (CE) group. Such modifications can enhance RNA stability and specificity in biochemical and therapeutic applications.

CAT: BRP-01126

CAS: 2253978-43-5

Molecular Formula: C57H66N5O12PS

Molecular Weight: 1076.21

Purity: ≥97% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: JILKHWGHHKCHDX-LEGKXAINSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=CC(=NC2=O)NC(=O)C=3C=CC=CC3)C1OCSCC=4C(OC)=CC(OC)=CC4OC)COC(C=5C=CC=CC5)(C6=CC=C(OC)C=C6)C7=CC=C(OC)C=C7)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2,4,6-trimethoxybenzyl)thio)methoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C57H66N5O12PS/c1-38(2)62(39(3)4)75(72-32-16-30-58)74-52-50(35-71-57(41-19-14-11-15-20-41,42-21-25-44(65-5)26-22-42)43-23-27-45(66-6)28-24-43)73-55(61-31-29-51(60-56(61)64)59-54(63)40-17-12-10-13-18-40)53(52)70-37-76-36-47-48(68-8)33-46(67-7)34-49(47)69-9/h10-15,17-29,31,33-34,38-39,50,52-53,55H,16,32,35-37H2,1-9H3,(H,59,60,63,64)/t50-,52-,53-,55-,75?/m1/s1

Synonyms: N4-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(2,4,6-trimethoxybenzylthiomethyl)-cytidine-3'-cyanoethyl Phosphoramidite

5'-O-DMTr-2'-O-TMBTM-G(iBu)-3'-CE-Phosphoramidite

Description: This phosphoramidite introduces a guanosine nucleoside where the 2'-hydroxyl group is modified with a TMBTM group and protected with a DMTr group at the 5'-position. It is modified with an isobutyryl (iBu) group at the 3'-position and protected with a CE group. Modifications like these can enhance RNA structure and function, impacting gene expression and regulatory mechanisms.

CAT: BRP-01127

CAS: 2253978-42-4

Molecular Formula: C55H68N7O12PS

Molecular Weight: 1082.22

Purity: ≥97% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: ZUFAHXPFYJOCTP-DRQNSODDSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C(=O)N=C(NC(=O)C(C)C)NC32)C1OCSCC=4C(OC)=CC(OC)=CC4OC)COC(C=5C=CC=CC5)(C6=CC=C(OC)C=C6)C7=CC=C(OC)C=C7)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(((2,4,6-trimethoxybenzyl)thio)methoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C55H68N7O12PS/c1-34(2)51(63)59-54-58-50-47(52(64)60-54)57-32-61(50)53-49(70-33-76-31-43-44(68-10)28-42(67-9)29-45(43)69-11)48(74-75(72-27-15-26-56)62(35(3)4)36(5)6)46(73-53)30-71-55(37-16-13-12-14-17-37,38-18-22-40(65-7)23-19-38)39-20-24-41(66-8)25-21-39/h12-14,16-25,28-29,32,34-36,46,48-49,53H,15,27,30-31,33H2,1-11H3,(H2,58,59,60,63,64)/t46-,48-,49-,53-,75?/m1/s1

Synonyms: N2-isobutyryl-5'-O-4,4'-(dimethoxytrityl)-2'-O-(2,4,6-trimethoxybenzylthiomethyl)-guanosine-3'-cyanoethyl Phosphoramidite

1-O-DMTr-Glycerol-TEG-Cholesterol-2-CE-Phosphoramidite

TEG Linker2

6-O-DMTr-hexane-bis-(diisopropylamino)-Phosphane

5'-O-DMTr-2'-O-(methoxycarbonyl)methyl-G(iBu)-3'-CE-Phosphoramidite

5'-O-DMTr-2'-O-(methoxycarbonyl)methyl-5-Me-C(iBu)-3'-CE-Phosphoramidite

5'-O-DMTr-2'-O-(methoxycarbonyl)methyl-5-Me-U-3'-CE-Phosphoramidite

5'-O-DMTr-2'-O-(methoxycarbonyl)methyl-A(Bz)-3'-CE-Phosphoramidite

5'-O-DMTr-2'-O-Me-8-Me-G(dmf)-3'-CE Phosphoramidite

5'-O-DMTr-7-deaza-2'-O-Me-G(iBu)-3'-CE-Phosphoramidite

O6-Protected-5'-DMT-2'-OMe-G(iBu)-CE-Phosphoramidite

DMT-1'-urea-2'-O-Me Amidite

5'-BzH-2'-OMe-Ur-3'-Methoxyphosphoramidite

5'-BzH-2'-OMe-Ac-Cr-3'-Methoxyphosphoramidite

O4-(p-tolyl pivalate)-5'-DMT-2'-OMe-U Phosphoramidite

Abasic MOE amidite (α,β mix)

2,6-diamino(N2,N6-diiBu)-DMT-2'-O-MOE-purine riboside-CE-Phosphoramidite

5'-DMT-2'-O-NMA-5-Me-U-3'-CE-Phosphoramidite

5'-O-DMTr-2'-O-TMBTM-A(Bz)-3'-CE-Phosphoramidite

5'-O-DMTr-2'-O-TMBTM-C(Bz)-3'-CE-Phosphoramidite

5'-O-DMTr-2'-O-TMBTM-G(iBu)-3'-CE-Phosphoramidite

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