Phosphoramidites - RNA / BOC Sciences

2,6-diamino(N2,N6-diPac)-DMT-2'-O-Me-purine riboside-CE-Phosphoramidite

Description: This phosphoramidite incorporates a purine nucleoside modified with a diPac (diphenoxyacetyl) group on the amino functionalities, a dimethoxytrityl (DMT) group on the 2'-hydroxyl of ribose. It is utilized in the synthesis of oligonucleotides where enhanced base pairing and stability are required, suitable for antisense technology and gene silencing applications.

CAT: BRP-01177

MF: C57H63N8O11P

MF: 1067.14

Purity: ≥98% by HPLC

Appearance: White to off-white powder

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InChIKey: GRQBYZJMCOKHGG-FDBJCFRMSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OC)N2C=NC3=C(N=C(N=C32)NC(=O)COC4=CC=CC=C4)NC(=O)COC5=CC=CC=C5)COC(C6=CC=CC=C6)(C7=CC=C(C=C7)OC)C8=CC=C(C=C8)OC

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-methoxyoxolan-2-yl]-2-[(2-phenoxyacetyl)amino]purin-6-yl]-2-phenoxyacetamide

InChI: InChI=1S/C57H63N8O11P/c1-38(2)65(39(3)4)77(74-33-17-32-58)76-51-47(34-73-57(40-18-11-8-12-19-40,41-24-28-43(68-5)29-25-41)42-26-30-44(69-6)31-27-42)75-55(52(51)70-7)64-37-59-50-53(60-48(66)35-71-45-20-13-9-14-21-45)62-56(63-54(50)64)61-49(67)36-72-46-22-15-10-16-23-46/h8-16,18-31,37-39,47,51-52,55H,17,33-36H2,1-7H3,(H2,60,61,62,63,66,67)/t47-,51-,52-,55-,77?/m1/s1

Synonyms: 2,6-Diamino-(N2,N6-diphenoxyacetyl)-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-purine riboside-3'-cyanoethyl phosphoramidite; (2R,3R,4R,5R)-5-(2,6-bis(2-phenoxyacetamido)-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; 2'-O-Methyl-2,6-diamino (N2,N6-diPAC)-purine-3'-CEP

5'-O-DMTr-2'-O-Me-A(iBu) PACE amidite

Description: This amidite contains an adenine nucleoside modified with a 5'-dimethoxytrityl (DMTr) group and a 2'-O-methyl (Me) group, suitable for solid-phase oligonucleotide synthesis. The iBu (isobutyryl) group enhances stability and compatibility during synthesis, ensuring efficient coupling and high purity of adenine-modified oligonucleotides.

CAT: BRP-01178

MF: C49H62N7O9P

MF: 924.05

Purity: ≥98% by HPLC

Appearance: White to pale yellow solid

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InChIKey: VIBUJWBMYBGTTQ-KMMWAEGCSA-N

IUPAC Name: 1-cyano-2-methylpropan-2-yl 2-((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(6-isobutyramido-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)acetate

InChI: InChI=1S/C49H62N7O9P/c1-31(2)46(58)54-44-41-45(52-29-51-44)55(30-53-41)47-43(61-11)42(65-66(56(32(3)4)33(5)6)28-40(57)64-48(7,8)25-26-50)39(63-47)27-62-49(34-15-13-12-14-16-34,35-17-21-37(59-9)22-18-35)36-19-23-38(60-10)24-20-36/h12-24,29-33,39,42-43,47H,25,27-28H2,1-11H3,(H,51,52,54,58)/t39-,42-,43-,47-,66?/m1/s1

Synonyms: 3'-O-(Diisopropylamino)phosphinoacetic acid α,α-dimethyl-β-cyanoethyl methyl ester N6-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyladenosine; 5'-O-DMTr-2'-O-Me-A(iBu) PACE; 5'-O-DMTr-2'-O-Me-A(iBu) PACE Phosphoramidite

5'-O-DMTr-2'-O-Me-G(Ac) PACE amidite

Description: This amidite incorporates a guanine nucleoside modified with a 5'-dimethoxytrityl (DMTr) group and a 2'-O-methyl (Me) group, along with an acetyl (Ac) group at the base. It is used in oligonucleotide synthesis to introduce modified guanine residues, offering versatility in structure and function studies of nucleic acids.

CAT: BRP-01179

MF: C47H58N7O10P

MF: 911.99

Purity: ≥98% by HPLC

Appearance: White to pale yellow solid

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InChIKey: QQXUTIPUYDMWLY-JONXRGCJSA-N

IUPAC Name: 1-cyano-2-methylpropan-2-yl 2-((((2R,3R,4R,5R)-5-(2-acetamido-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)acetate

InChI: InChI=1S/C47H58N7O10P/c1-29(2)54(30(3)4)65(27-38(56)63-46(6,7)24-25-48)64-40-37(62-44(41(40)60-10)53-28-49-39-42(53)51-45(50-31(5)55)52-43(39)57)26-61-47(32-14-12-11-13-15-32,33-16-20-35(58-8)21-17-33)34-18-22-36(59-9)23-19-34/h11-23,28-30,37,40-41,44H,24,26-27H2,1-10H3,(H2,50,51,52,55,57)/t37-,40-,41-,44-,65?/m1/s1

Synonyms: 3'-O-(Diisopropylamino)phosphinoacetic acid α,α-dimethyl-β-cyanoethyl methyl ester N2-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methylguanosine; 5'-O-DMTr-2'-O-Me-G(Ac) PACE; 5'-O-DMTr-2'-O-Me-G(Ac) PACE Phosphoramidite

Morpholino A(Ceoc) subunit

Description: This subunit consists of a morpholino ring (a six-membered morpholine ring) modified with a Ceoc group attached to an adenine base. Morpholinos are synthetic nucleic acid analogs used primarily as antisense agents to block gene expression by binding to complementary RNA sequences, offering potential therapeutic applications in gene regulation and disease treatment.

CAT: BRP-01180

MF: C35H36ClN8O5P

MF: 715.15

Purity: ≥98% by UPLC

Appearance: White, off-white to light yellow powder

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InChIKey: AELIKKSXAYGGHK-YYNRDWDXSA-N

IUPAC Name: 2-cyanoethyl (9-((2R,6S)-6-(((chloro(dimethylamino)phosphoryl)oxy)methyl)-4-tritylmorpholin-2-yl)-9H-purin-6-yl)carbamate

InChI: InChI=1S/C35H36ClN8O5P/c1-42(2)50(36,46)48-23-29-21-43(35(26-13-6-3-7-14-26,27-15-8-4-9-16-27)28-17-10-5-11-18-28)22-30(49-29)44-25-40-31-32(38-24-39-33(31)44)41-34(45)47-20-12-19-37/h3-11,13-18,24-25,29-30H,12,20-23H2,1-2H3,(H,38,39,41,45)/t29-,30+,50?/m0/s1

Synonyms: 2-cyanoethyl (9-(6-(((chloro(dimethylamino)phosphoryl)oxy)methyl)-4-tritylmorpholin-2-yl)-9H-purin-6-yl)carbamate

Morpholino C(Ceoc) subunit

Description: This variant features a morpholino ring modified with a Ceoc group linked to a cytosine base. It serves similar purposes as the A(Ceoc) subunit in antisense technology, facilitating selective binding to RNA targets for gene knockdown and therapeutic interventions.

CAT: BRP-01181

MF: C34H36ClN6O6P

MF: 691.12

Purity: ≥98% by UPLC

Appearance: White, off-white to light yellow powder

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InChIKey: NNFJEBJVHVPSJG-HYZMJWPCSA-N

IUPAC Name: 2-cyanoethyl (1-((2R,6S)-6-(((chloro(dimethylamino)phosphoryl)oxy)methyl)-4-tritylmorpholin-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)carbamate

InChI: InChI=1S/C34H36ClN6O6P/c1-39(2)48(35,44)46-25-29-23-40(24-31(47-29)41-21-19-30(37-32(41)42)38-33(43)45-22-12-20-36)34(26-13-6-3-7-14-26,27-15-8-4-9-16-27)28-17-10-5-11-18-28/h3-11,13-19,21,29,31H,12,22-25H2,1-2H3,(H,37,38,42,43)/t29-,31+,48?/m0/s1

Synonyms: 2-cyanoethyl (1-(6-(((chloro(dimethylamino)phosphoryl)oxy)methyl)-4-tritylmorpholin-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)carbamate

Boc-PNA-C(Z)-OH

Description: Boc-PNA-C(Z)-OH is a synthetic peptide nucleic acid (PNA) monomer with a cytosine base. It features a BOC (tert-butyloxycarbonyl) protecting group and a Z (benzyloxycarbonyl) group. This monomer is utilized in the synthesis of PNA oligomers for molecular biology and genetic research, particularly in the study of DNA and RNA interactions and hybridization.

CAT: BRP-01182

CAS: 144564-94-3

MF: C23H29N5O8

MF: 503.51

Purity: ≥97% by HPLC

Appearance: White, off-white to faint yellow powder

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Storage: Store at 2-8 °C, in tightly closed container, protected from light and humidity

Density: 1.32±0.1 g/cm3

Melting Point: 156 °C (dec.)

InChIKey: UCPRPVFFEVZHEJ-UHFFFAOYSA-N

CanonicalSMILES: CC(C)(C)OC(=O)NCCN(CC(=O)O)C(=O)CN1C=CC(=NC1=O)NC(=O)OCC2=CC=CC=C2

IUPAC Name: 2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethyl-[2-[2-oxo-4-(phenylmethoxycarbonylamino)pyrimidin-1-yl]acetyl]amino]acetic acid

InChI: InChI=1S/C23H29N5O8/c1-23(2,3)36-21(33)24-10-12-27(14-19(30)31)18(29)13-28-11-9-17(25-20(28)32)26-22(34)35-15-16-7-5-4-6-8-16/h4-9,11H,10,12-15H2,1-3H3,(H,24,33)(H,30,31)(H,25,26,32,34)

Synonyms: N-((N4-(benzyloxycarbonyl)cytosine-9-yl)acetyl)-N-(2-Boc-aminoethyl)glycine; N-[2-[[(1,1-Dimethylethoxy)carbonyl]amino]ethyl]-N-[2-[2-oxo-4-[[(phenylmethoxy)carbonyl]amino]-1(2H)-pyrimidinyl]acetyl]glycine; 2-(2-(4-(benzyloxycarbonylamino)-2-oxopyrimidin-1(2H)-yl)-N-(2-(tert-butoxycarbonylamino) ethyl)acetamido)acetic acid; Boc-Aeg(C[z])-OH

Boc-PNA-A(Z)-OH

Description: Boc-PNA-A(Z)-OH is a synthetic peptide nucleic acid (PNA) monomer with an adenine base. It features a Boc (tert-butyloxycarbonyl) protecting group and a Z (benzyloxycarbonyl) group. This monomer is used in the synthesis of PNA oligomers for research in molecular biology and genetics, particularly for studying DNA and RNA binding and hybridization.

CAT: BRP-01183

CAS: 149376-69-2

MF: C24H29N7O7

MF: 527.53

Purity: ≥97% by HPLC

Appearance: White, off-white to faint yellow powder

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Storage: Store at 2-8 °C, in tightly closed container, protected from light and humidity

Density: 1.38±0.1 g/cm3

Melting Point: 119 °C (dec.)

InChIKey: HNSNKXSLRGSKQN-UHFFFAOYSA-N

CanonicalSMILES: CC(C)(C)OC(=O)NCCN(CC(=O)O)C(=O)CN1C=NC2=C(N=CN=C21)NC(=O)OCC3=CC=CC=C3

IUPAC Name: 2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethyl-[2-[6-(phenylmethoxycarbonylamino)purin-9-yl]acetyl]amino]acetic acid

InChI: InChI=1S/C24H29N7O7/c1-24(2,3)38-22(35)25-9-10-30(12-18(33)34)17(32)11-31-15-28-19-20(26-14-27-21(19)31)29-23(36)37-13-16-7-5-4-6-8-16/h4-8,14-15H,9-13H2,1-3H3,(H,25,35)(H,33,34)(H,26,27,29,36)

Synonyms: N-((N6-(benzyloxycarbonyl)adenin-9-yl)acetyl)-N-(2-Boc-aminoethyl)glycine; N-(2-(6-(((Benzyloxy)carbonyl)amino)-9H-purin-9-yl)acetyl)-N-(2-((tert-butoxycarbonyl)amino)ethyl)glycine; N-[2-[[(1,1-Dimethylethoxy)carbonyl]amino]ethyl]-N-[2-[6-[[(phenylmethoxy)carbonyl]amino]-9H-purin-9-yl]acetyl]glycine

N1-Me-5'-O-DMTr-2'-O-TBDMS-G(dmf)-3'-CE-Phosphoramidite

Description: This phosphoramidite consists of a guanosine nucleoside modified with N1-methyl (N1-Me), 5'-dimethoxytrityl (DMTr), 2'-O-tert-butyldimethylsilyl (TBDMS), and a dmf (dimethylformamide) group linked to the base. It is used in solid-phase synthesis to introduce modified guanosine residues into oligonucleotides, providing stability and compatibility during synthesis.

CAT: BRP-01184

MF: C50H69N8O8PSi

MF: 969.21

Purity: ≥97% by HPLC

Appearance: White, off-white to light yellow powder

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InChIKey: VNPNGTSSGZPPHO-PGKNMGFDSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C(=O)N(C(N=CN(C)C)=NC32)C)C1O[Si](C)(C)C(C)(C)C)COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2-(((dimethylamino)methylene)amino)-1-methyl-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C50H69N8O8PSi/c1-34(2)58(35(3)4)67(63-30-18-29-51)65-43-41(31-62-50(36-19-16-15-17-20-36,37-21-25-39(60-11)26-22-37)38-23-27-40(61-12)28-24-38)64-47(44(43)66-68(13,14)49(5,6)7)57-33-52-42-45(57)54-48(53-32-55(8)9)56(10)46(42)59/h15-17,19-28,32-35,41,43-44,47H,18,30-31H2,1-14H3/t41-,43-,44-,47-,67?/m1/s1

Synonyms: N1-methyl-N2-dimethylformamide-5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyl-dimethylsilyl)-guanosine-3'-cyanoethyl Phosphoramidite

5'-O-DMT-2'-O-TBDMS-G(Me)-3'-CE-Phosphoramidite

Description: This phosphoramidite contains a guanosine nucleoside modified with a 5'-dimethoxytrityl (DMT) group, a 2'-O-tert-butyldimethylsilyl (TBDMS) group, and a methyl (Me) group. It is utilized in oligonucleotide synthesis to incorporate guanine modifications, offering enhanced stability and specificity in nucleic acid interactions.

CAT: BRP-01185

MF: C47H64N7O8PSi

MF: 914.13

Purity: ≥97% by UPLC

Appearance: White, off-white to light yellow powder

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InChIKey: RNYXUWAQJPNBRD-SLLDXECHSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2-(methylamino)-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C47H64N7O8PSi/c1-31(2)54(32(3)4)63(59-28-16-27-48)61-40-38(60-44(41(40)62-64(11,12)46(5,6)7)53-30-50-39-42(53)51-45(49-8)52-43(39)55)29-58-47(33-17-14-13-15-18-33,34-19-23-36(56-9)24-20-34)35-21-25-37(57-10)26-22-35/h13-15,17-26,30-32,38,40-41,44H,16,28-29H2,1-12H3,(H2,49,51,52,55)/t38-,40-,41-,44-,63?/m1/s1

Synonyms: N2-methyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyl-dimethylsilyl)-guanosine-3'-cyanoethyl Phosphoramidite; 5'-O-DMT-2'-O-TBDMS-dG(Me)-3'-CE-Phosphoramidite

N1-Me-5'-O-DMTr-2'-O-TBDMS-G(iPr-pac)-3'-CE-Phosphoramidite

Description: This phosphoramidite features a guanosine nucleoside with N1-methyl (N1-Me), 5'-dimethoxytrityl (DMTr), 2'-O-tert-butyldimethylsilyl (TBDMS), and isopropylphenoxyacetyl (iPr-Pac)-protected phosphoramidite groups. It is employed in oligonucleotide synthesis to introduce modified guanine residues, enhancing stability and functionality for various biomedical and research applications.

CAT: BRP-01186

MF: C58H76N7O10PSi

MF: 1090.34

Purity: ≥97% by UPLC

Appearance: White, off-white to light yellow powder

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InChIKey: FDSKQAUYTVNZJK-YCBNDBQVSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2-(2-(4-isopropylphenoxy)acetamido)-1-methyl-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C58H76N7O10PSi/c1-38(2)41-21-27-47(28-22-41)70-36-49(66)61-56-62-53-50(54(67)63(56)10)60-37-64(53)55-52(75-77(13,14)57(7,8)9)51(74-76(72-34-18-33-59)65(39(3)4)40(5)6)48(73-55)35-71-58(42-19-16-15-17-20-42,43-23-29-45(68-11)30-24-43)44-25-31-46(69-12)32-26-44/h15-17,19-32,37-40,48,51-52,55H,18,34-36H2,1-14H3,(H,61,62,66)/t48-,51-,52-,55-,76?/m1/s1

Synonyms: N1-methyl-N2-(p-isopropyl-phenoxyacetyl)-5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyl-dimethylsilyl)-guanosine-3'-cyanoethyl Phosphoramidite

2'-O-TBDMS-5'-trifluoroacetamido-U-3'-CE-Phosphoramidite

Description: This phosphoramidite contains a uridine nucleoside modified with a 2'-O-tert-butyldimethylsilyl (TBDMS) group and a 5'-trifluoroacetamido (TFA) group. It is used in oligonucleotide synthesis to incorporate modified uridine residues, providing enhanced stability and specific interactions in nucleic acid hybridization studies and therapeutic applications.

CAT: BRP-01187

MF: C26H43F3N5O7PSi

MF: 653.70

Purity: ≥97% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: JJJISHQDDQBWAN-OJHMZDIXSA-N

IUPAC Name: (2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-((2,2,2-trifluoroacetamido)methyl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C26H43F3N5O7PSi/c1-16(2)34(17(3)4)42(38-14-10-12-30)40-20-18(15-31-23(36)26(27,28)29)39-22(33-13-11-19(35)32-24(33)37)21(20)41-43(8,9)25(5,6)7/h11,13,16-18,20-22H,10,14-15H2,1-9H3,(H,31,36)(H,32,35,37)/t18-,20-,21-,22-,42?/m1/s1

Synonyms: 2'-O-(t-butyl-dimethylsilyl)-5'-trifluoroacetamido-uridine-3'-[(2-cyanoethyl)-N,N-diisopropyl] phosphoramidite

[5'-O-DMTr-2'-OMe-U](pCyEt)[2'-O-Me-U](pCyEt)[2'-OMe-U-3'-CE-Phosphoramidite]

Description: [5'-O-DMTr-2'-OMe-U](pCyEt)[2'-O-Me-U](pCyEt)[2'-OMe-U-3'-CE-Phosphoramidite] is a complex modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of three sequentially linked nucleosides: a 5'-O-DMTr-2'-OMe-uridine (U), a second 2'-OMe-uridine, and a third 2'-OMe-uridine. Each linkage is protected by a cyanoethyl (CE) group, ensuring stability during synthesis. These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making them valuable for advanced biochemical research and therapeutic applications.

CAT: BRP-01188

MF: C66H81N10O25P3

MF: 1507.34

Purity: ≥90% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: RVLLLKZWUNUMEY-BNMQGBNESA-N

IUPAC Name: (2R,3R,4R,5R)-2-((((((2R,3R,4R,5R)-2-((((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C66H81N10O25P3/c1-41(2)76(42(3)4)102(91-35-13-29-67)99-54-49(97-60(57(54)87-7)73-32-26-51(77)70-63(73)80)39-94-103(83,92-36-14-30-68)101-56-50(98-62(59(56)89-9)75-34-28-53(79)72-65(75)82)40-95-104(84,93-37-15-31-69)100-55-48(96-61(58(55)88-8)74-33-27-52(78)71-64(74)81)38-90-66(43-16-11-10-12-17-43,44-18-22-46(85-5)23-19-44)45-20-24-47(86-6)25-21-45/h10-12,16-28,32-34,41-42,48-50,54-62H,13-15,35-40H2,1-9H3,(H,70,77,80)(H,71,78,81)(H,72,79,82)/t48-,49-,50-,54-,55-,56-,57-,58-,59-,60-,61-,62-,102?,103?,104?/m1/s1

Synonyms: mU[5'-O-DMTr-2'-OMe-U](pCyEt)[2'-O-Me-U](pCyEt)[2'-OMe-U-3'-CE-Phosphoramidite]mU-mU

PMO-CAG trimer phosphoramidochloridate

Description: PMO-CAG trimer phosphoramidochloridate is a chemically modified oligonucleotide used in molecular biology and therapeutic applications. It consists of a trimer sequence (Cytosine-Adenine-Guanine, CAG) within a phosphorodiamidate morpholino oligomer (PMO) backbone. The phosphoramidate group is modified with a chloridate moiety, which aids in coupling the trimer to other molecular structures or sequences during synthesis. This configuration enhances the stability, binding affinity, and resistance to nucleases, making it a valuable tool for gene modulation, antisense therapies, and other nucleic acid-based applications.

CAT: BRP-01189

MF: C80H90ClN20O16P3

MF: 1716.10

Purity: ≥90% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: NCZHWRORJFEAOK-UTKGGJPZSA-N

IUPAC Name: ((2S,6R)-6-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-4-((((2S,6R)-6-(6-benzamido-9H-purin-9-yl)-4-((dimethylamino)(((2S,6R)-6-(2-isobutyramido-6-(4-nitrophenethoxy)-9H-purin-9-yl)-4-tritylmorpholin-2-yl)methoxy)phosphoryl)morpholin-2-yl)methoxy)(dimethylamino)phosphoryl)morpholin-2-yl)methyl dimethylphosphoramidochloridate

InChI: InChI=1S/C80H90ClN20O16P3/c1-54(2)74(102)90-78-89-73-70(77(91-78)111-41-39-55-34-36-61(37-35-55)101(106)107)85-53-100(73)66-45-95(80(58-28-18-11-19-29-58,59-30-20-12-21-31-59)60-32-22-13-23-33-60)42-62(115-66)49-113-120(110,94(7)8)97-44-64(117-68(47-97)99-52-84-69-71(82-51-83-72(69)99)88-76(104)57-26-16-10-17-27-57)50-114-119(109,93(5)6)96-43-63(48-112-118(81,108)92(3)4)116-67(46-96)98-40-38-65(87-79(98)105)86-75(103)56-24-14-9-15-25-56/h9-38,40,51-54,62-64,66-68H,39,41-50H2,1-8H3,(H,82,83,88,104)(H,86,87,103,105)(H,89,90,91,102)/t62-,63-,64-,66+,67+,68+,118?,119?,120?/m0/s1

Synonyms: PMO-C(Ac)A(Bz)G(iBu) trimer phosphoramidochloridate

[5'-O-DMTr-2'-F-dC(Ac)](pCyEt)[2'-OMe-U](pCyEt)[2'-F-dG(iBu)-3'-CE-Phosphoramidite]

Description: [5'-O-DMTr-2'-F-dC(Ac)](pCyEt)[2'-OMe-U](pCyEt)[2'-F-dG(iBu)-3'-CE-Phosphoramidite] is a complex modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of three sequentially linked nucleosides: a 5'-O-DMTr-2'-fluoro-deoxycytidine (2'-F-dC) with an acetyl (Ac) protecting group, a 2'-O-methyl-uridine (2'-OMe-U), and a 2'-fluoro-deoxyguanosine (2'-F-dG) with an isobutyryl (iBu) protecting group. Each linkage is protected by a cyanoethyl (CE) group, ensuring stability during synthesis. These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making them valuable for advanced biochemical research and therapeutic applications.

CAT: BRP-01190

MF: C71H85F2N14O23P3

MF: 1633.45

Purity: ≥92% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: LFFQMQJBVLQFPU-VKWGPYKVSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((((((2R,3R,4R,5R)-2-((((((2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-4-fluoro-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C71H85F2N14O23P3/c1-41(2)63(90)82-68-81-62-57(64(91)83-68)77-40-86(62)66-55(72)58(108-111(100-34-14-29-74)87(42(3)4)43(5)6)51(106-66)38-103-113(95,102-36-16-31-76)110-60-52(107-67(61(60)98-10)85-33-28-54(89)80-70(85)93)39-104-112(94,101-35-15-30-75)109-59-50(105-65(56(59)73)84-32-27-53(78-44(7)88)79-69(84)92)37-99-71(45-17-12-11-13-18-45,46-19-23-48(96-8)24-20-46)47-21-25-49(97-9)26-22-47/h11-13,17-28,32-33,40-43,50-52,55-56,58-61,65-67H,14-16,34-39H2,1-10H3,(H,80,89,93)(H,78,79,88,92)(H2,81,82,83,90,91)/t50-,51-,52-,55-,56-,58-,59-,60-,61-,65-,66-,67-,111?,112?,113?/m1/s1

mU[5'-O-DMTr-2'-OMe-U](pCyEt)[2'-O-Me-G(iBu)](pCyEt)[2'-OMe-U-3'-CE-Phosphoramidite]-mG-Mu

Description: mU[5'-O-DMTr-2'-OMe-U](pCyEt)[2'-O-Me-G(iBu)](pCyEt)[2'-OMe-U-3'-CE-Phosphoramidite]-mG-Mu is a complex modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of three sequentially linked nucleosides: a 5'-O-DMTr-2'-O-methyl-uridine (2'-OMe-U), a 2'-O-methyl-guanosine (2'-OMe-G) with an isobutyryl (iBu) protecting group, and another 2'-O-methyl-uridine (2'-OMe-U). Each linkage is protected by a cyanoethyl (CE) group, ensuring stability during synthesis. These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making them valuable for advanced biochemical research and therapeutic applications.

CAT: BRP-01191

MF: C71H88N13O25P3

MF: 1616.47

Purity: ≥90% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: LHSQAKDMIMJKFU-FSOKJIOASA-N

IUPAC Name: (2R,3R,4R,5R)-2-((((((2R,3R,4R,5R)-2-((((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C71H88N13O25P3/c1-42(2)63(87)79-68-78-62-55(64(88)80-68)75-41-83(62)67-61(97-11)58(109-111(91,100-36-16-31-73)102-39-51-56(107-110(99-35-15-30-72)84(43(3)4)44(5)6)59(95-9)65(105-51)81-33-28-53(85)76-69(81)89)52(106-67)40-103-112(92,101-37-17-32-74)108-57-50(104-66(60(57)96-10)82-34-29-54(86)77-70(82)90)38-98-71(45-18-13-12-14-19-45,46-20-24-48(93-7)25-21-46)47-22-26-49(94-8)27-23-47/h12-14,18-29,33-34,41-44,50-52,56-61,65-67H,15-17,35-40H2,1-11H3,(H,76,85,89)(H,77,86,90)(H2,78,79,80,87,88)/t50-,51-,52-,56-,57-,58-,59-,60-,61-,65-,66-,67-,110?,111?,112?/m1/s1

Synonyms: [5'-O-DMTr-2'-OMe-U](pCyEt)[2'-O-Me-G(iBu)](pCyEt)[2'-OMe-U-3'-CE-Phosphoramidite]; UmGmUm

[5'-O-DMTr-2'-OMe-C(Ac)](P-thio-pCyEt)[2'-OMe-U](P-thio-pCyEt)[2'-OMe-A(Bz)-3'-CE-Phosphoramidite]

Description: [5'-O-DMTr-2'-OMe-C(Ac)](P-thio-pCyEt)[2'-OMe-U](P-thio-pCyEt)[2'-OMe-A(Bz)-3'-CE-Phosphoramidite] is a complex modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of three sequentially linked nucleosides: a 5'-O-DMTr-2'-O-methyl-cytidine (2'-OMe-C) with an acetyl (Ac) protecting group, a 2'-O-methyl-uridine (2'-OMe-U), and a 2'-O-methyl-adenosine (2'-OMe-A) with a benzoyl (Bz) protecting group. Each linkage is protected by a phosphorothioate (P-thio) group and a cyanoethyl (CE) group, ensuring stability during synthesis. These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making them valuable for advanced biochemical research and therapeutic applications.

CAT: BRP-01192

MF: C76H89N14O22P3S2

MF: 1707.67

Purity: ≥90% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: YRUITVGNVXNUNZ-QPPMCZIUSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((((((2R,3R,4R,5R)-2-((((((2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphorothioyl)oxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphorothioyl)oxy)methyl)-5-(6-benzamido-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C76H89N14O22P3S2/c1-47(2)90(48(3)4)113(102-39-17-34-77)110-62-57(108-73(65(62)98-8)89-46-82-61-68(80-45-81-69(61)89)86-70(93)50-20-13-11-14-21-50)43-105-114(116,103-40-18-35-78)112-64-58(109-72(67(64)100-10)88-38-33-60(92)85-75(88)95)44-106-115(117,104-41-19-36-79)111-63-56(107-71(66(63)99-9)87-37-32-59(83-49(5)91)84-74(87)94)42-101-76(51-22-15-12-16-23-51,52-24-28-54(96-6)29-25-52)53-26-30-55(97-7)31-27-53/h11-16,20-33,37-38,45-48,56-58,62-67,71-73H,17-19,39-44H2,1-10H3,(H,85,92,95)(H,80,81,86,93)(H,83,84,91,94)/t56-,57-,58-,62-,63-,64-,65-,66-,67-,71-,72-,73-,113?,114?,115?/m1/s1

Synonyms: mC[5'-O-DMTr-2'-OMe-C(Ac)](P-thio-pCyEt)[2'-OMe-U](P-thio-pCyEt)[2'-OMe-A(Bz)-3'-CE-Phosphoramidite]mU-mA

[5'-O-DMTr-2'-OMe-U](pCyEt)[2'-O-Me-G(iBu)](pCyEt)[2'-OMe-C(Ac)-3'-CE-Phosphoramidite]

Description: [5'-O-DMTr-2'-OMe-U](pCyEt)[2'-O-Me-G(iBu)](pCyEt)[2'-OMe-C(Ac)-3'-CE-Phosphoramidite] is a complex modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of three sequentially linked nucleosides: a 5'-O-DMTr-2'-O-methyl-uridine (2'-OMe-U), a 2'-O-methyl-guanosine (2'-OMe-G) with an isobutyryl (iBu) protecting group, and a 2'-O-methyl-cytidine (2'-OMe-C) with an acetyl (Ac) protecting group. Each linkage is protected by a cyanoethyl (CE) group, ensuring stability during synthesis. These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making them valuable for advanced biochemical research and therapeutic applications.

CAT: BRP-01193

MF: C73H91N14O25P3

MF: 1657.53

Purity: ≥90% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: CTRIMGUISJCSNZ-VILHZJDJSA-N

IUPAC Name: (2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((((((2R,3R,4R,5R)-2-((((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C73H91N14O25P3/c1-43(2)65(90)82-70-81-64-57(66(91)83-70)77-42-86(64)69-63(100-12)60(112-114(94,103-37-17-32-75)105-40-53-58(110-113(102-36-16-31-74)87(44(3)4)45(5)6)61(98-10)67(108-53)84-34-29-55(78-46(7)88)79-71(84)92)54(109-69)41-106-115(95,104-38-18-33-76)111-59-52(107-68(62(59)99-11)85-35-30-56(89)80-72(85)93)39-101-73(47-19-14-13-15-20-47,48-21-25-50(96-8)26-22-48)49-23-27-51(97-9)28-24-49/h13-15,19-30,34-35,42-45,52-54,58-63,67-69H,16-18,36-41H2,1-12H3,(H,80,89,93)(H,78,79,88,92)(H2,81,82,83,90,91)/t52-,53-,54-,58-,59-,60-,61-,62-,63-,67-,68-,69-,113?,114?,115?/m1/s1

Synonyms: mU[5'-O-DMTr-2'-OMe-U](pCyEt)[2'-O-Me-G(iBu)](pCyEt)[2'-OMe-C(Ac)-3'-CE-Phosphoramidite]mG-mC

[5'-O-DMTr-2'-OMe-G(iBu)](pCyEt)[2'-OMe-A(Bz)](pCyEt)[2'-OMe-C(Ac)-3'-CE-Phosphoramidite]

Description: [5'-O-DMTr-2'-OMe-G(iBu)](pCyEt)[2'-OMe-A(Bz)](pCyEt)[2'-OMe-C(Ac)-3'-CE-Phosphoramidite] is a complex modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of three sequentially linked nucleosides: a 5'-O-DMTr-2'-O-methyl-guanosine (2'-OMe-G) with an isobutyryl (iBu) protecting group, a 2'-O-methyl-adenosine (2'-OMe-A) with a benzoyl (Bz) protecting group, and a 2'-O-methyl-cytidine (2'-OMe-C) with an acetyl (Ac) protecting group. Each linkage is protected by a cyanoethyl (CE) group, ensuring stability during synthesis. These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making them valuable for advanced biochemical research and therapeutic applications.

CAT: BRP-01194

MF: C81H96N17O24P3

MF: 1784.68

Purity: ≥90% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: OTKBGJKLKVYCOV-FEONMEANSA-N

IUPAC Name: (2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((((((2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-4-methoxytetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C81H96N17O24P3/c1-48(2)73(100)93-79-92-72-63(75(102)94-79)88-47-97(72)78-68(109-11)65(58(117-78)42-111-81(53-24-17-14-18-25-53,54-26-30-56(106-8)31-27-54)55-28-32-57(107-9)33-29-55)121-125(105,114-41-21-37-84)116-44-60-66(69(110-12)77(119-60)96-46-87-62-70(85-45-86-71(62)96)91-74(101)52-22-15-13-16-23-52)122-124(104,113-40-20-36-83)115-43-59-64(120-123(112-39-19-35-82)98(49(3)4)50(5)6)67(108-10)76(118-59)95-38-34-61(89-51(7)99)90-80(95)103/h13-18,22-34,38,45-50,58-60,64-69,76-78H,19-21,39-44H2,1-12H3,(H,85,86,91,101)(H,89,90,99,103)(H2,92,93,94,100,102)/t58-,59-,60-,64-,65-,66-,67-,68-,69-,76-,77-,78-,123?,124?,125?/m1/s1

Synonyms: mG[5'-O-DMTr-2'-OMe-G(iBu)](pCyEt)[2'-OMe-A(Bz)](pCyEt)[2'-OMe-C(Ac)-3'-CE-Phosphoramidite]mA-mC

TFA-Aminobutyl-1-3-propanediol-DMT succinate, TEA salt

Description: TFA-Aminobutyl-1-3-propanediol-DMT succinate, TEA salt, is a synthetic intermediate or compound used in organic chemistry and biochemical research. It features a trifluoroacetyl (TFA) group, an aminobutyl-1,3-propanediol moiety, and a dimethoxytrityl (DMT) protection group linked to a succinate modification. This compound is utilized in solid-phase synthesis of molecules and potentially in drug discovery processes where chemical modifications and protection groups are essential for the development and manipulation of organic molecules.

CAT: BRP-01241

MF: C34H38F3NO8 (free acid)

MF: 645.67 (free acid)

Purity: ≥98% by UPLC

Appearance: Colorless to yellow oily matter

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IUPAC Name: 4-((2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-6-(2,2,2-trifluoroacetamido)hexyl)oxy)-4-oxobutanoic acid;N,N-diethylethanamine

Synonyms: Trifluoroacetatyl-Aminobutyl-1-3-Propanediol-DMT Succinate, TEA salt

3-O-DMT-2,2-(dicarboxymethylamido)propyl-1-O-succinate, TEA salt

Description: 3-O-DMT-2,2-(dicarboxymethylamido)propyl-1-O-succinate, TEA salt is a chemical compound stabilized with triethylamine (TEA) salt. This compound is likely used in organic synthesis as an intermediate or precursor for the modification of biomolecules or organic compounds, particularly in solid-phase synthesis or other chemical reactions requiring stable protection groups and functional groups for further manipulation.

CAT: BRP-01242

MF: C32H36N2O9 (free acid)

MF: 592.65 (free acid)

Purity: ≥97% by HPLC

Appearance: White, off-white to light yellow powder

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IUPAC Name: 4-(2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-(methylamino)-2-(methylcarbamoyl)-3-oxopropoxy)-4-oxobutanoic acid;N,N-diethylethanamine

Synonyms: 3-(4,4'-dimethoxytrityloxy)-2,2-(dicarboxymethylamido)propyl-1-O-succinate, triethylamine salt