Phosphoramidites

2-Cyanoethyl (6-(3-(prop-2-yn-1-yloxy)-2,2-bis((prop-2-yn-1-yloxy)methyl)propoxy)hexyl) diisopropylphosphoramidite

Description: This phosphoramidite is utilized in solid-phase oligonucleotide synthesis. The cyanoethyl group protects the phosphate backbone during synthesis, while the complex linker (prop-2-yn-1-yloxy and propoxy groups) allows for the attachment of nucleoside units. This modification facilitates the creation of oligonucleotides with specific functionalities and structures for various research and therapeutic applications.

CAT: BRP-01168

Molecular Formula: C29H47N2O6P

Molecular Weight: 550.68

Purity: ≥98% by HPLC

Appearance: Colorless, pale yellow to yellow oily matter

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InChIKey: UGCIERZKKRAEPJ-UHFFFAOYSA-N

CanonicalSMILES: N#CCCOP(OCCCCCCOCC(COCC#C)(COCC#C)COCC#C)N(C(C)C)C(C)C

InChI: InChI=1S/C29H47N2O6P/c1-8-17-32-23-29(24-33-18-9-2,25-34-19-10-3)26-35-20-13-11-12-14-21-36-38(37-22-15-16-30)31(27(4)5)28(6)7/h1-3,27-28H,11-15,17-26H2,4-7H3

TEG-GalNAc Cluster Amidite

Description: TEG-GalNAc amidite is employed in the synthesis of oligonucleotides conjugated with GalNAc clusters. GalNAc conjugation facilitates targeted delivery of oligonucleotides to hepatocytes, enhancing therapeutic efficacy in treatments for liver-related diseases such as familial hypercholesterolemia and hepatic cancers.

CAT: BRP-01169

Molecular Formula: C61H89N4O19P

Molecular Weight: 1213.37

Purity: ≥97%

Appearance: White to light yellow powder

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InChIKey: ZBBIFTGXXMNXRH-CKGCLIAUSA-N

CanonicalSMILES: CC(O[C@H]([C@H]([C@@H]1OCCCCC(NCCCOCCOCCOCCOCC(OP(OCCC#N)N(C(C)C)C(C)C)COC(C2=CC=CC=C2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)=O)NC(C)=O)[C@H]([C@H](O1)COC(C)=O)OC(C)=O)=O

IUPAC Name: (2R,3R,4R,5R,6R)-5-acetamido-2-(acetoxymethyl)-6-((4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-1,1-bis(4-methoxyphenyl)-20-oxo-1-phenyl-2,6,9,12,15-pentaoxa-19-azatetracosan-24-yl)oxy)tetrahydro-2H-pyran-3,4-diyl diacetate

InChI: InChI=1S/C61H89N4O19P/c1-43(2)65(44(3)4)85(80-33-16-29-62)84-54(41-79-61(49-18-12-11-13-19-49,50-21-25-52(71-9)26-22-50)51-23-27-53(72-10)28-24-51)40-76-39-38-75-37-36-74-35-34-73-31-17-30-63-56(70)20-14-15-32-77-60-57(64-45(5)66)59(82-48(8)69)58(81-47(7)68)55(83-60)42-78-46(6)67/h11-13,18-19,21-28,43-44,54-55,57-60H,14-17,20,30-42H2,1-10H3,(H,63,70)(H,64,66)/t54?,55-,57-,58+,59-,60-,85?/m1/s1

Synonyms: GalNAc PEG Cluster Phosphoramidite; Tetraethylene glycol-N-acetylgalactosamine Amidite

DMTr-hydroxymethyl hexyl-Biotin Phosphoramidite

Description: This phosphoramidite incorporates biotin linked via a hydroxymethyl hexyl spacer, protected with a dimethoxytrityl (DMTr) group. Biotin is widely used in biochemical assays for affinity purification, protein detection, and as a molecular tag in nucleic acid hybridization studies. This modification enables specific and sensitive detection and isolation of biotinylated oligonucleotides or biomolecules.

CAT: BRP-01170

CAS: 1021702-07-7

Molecular Formula: C47H66N5O7PS

Molecular Weight: 876.11

Purity: ≥97% by UPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: GMVCCUAXEMZEJE-OYSBNFJTSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OCC(CCCCNC(=O)CCCCC1C2C(CS1)NC(=O)N2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-6-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyhexyl]pentanamide

InChI: InChI=1S/C47H66N5O7PS/c1-34(2)52(35(3)4)60(58-30-14-28-48)59-32-36(15-12-13-29-49-44(53)19-11-10-18-43-45-42(33-61-43)50-46(54)51-45)31-57-47(37-16-8-7-9-17-37,38-20-24-40(55-5)25-21-38)39-22-26-41(56-6)27-23-39/h7-9,16-17,20-27,34-36,42-43,45H,10-15,18-19,29-33H2,1-6H3,(H,49,53)(H2,50,51,54)/t36?,42-,43-,45-,60?/m0/s1

Synonyms: DMTr-hydroxymethyl hexyl-Biotin Phosphoramidite; 2-[[Bis(4-methoxyphenyl)phenylmethoxy]methyl]-6-[[5-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]hexyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-6-[[5-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]hexyl 2-cyanoethyl ester

1,3-di-O-DMTr-glycerol-bis-(diisopropylamino)-Phosphane

Description: This phosphoramidite features a glycerol backbone modified with two DMTr groups and diisopropylamino phosphane groups. It facilitates efficient coupling reactions during solid-phase oligonucleotide synthesis, ensuring high purity and yield. The glycerol spacer enhances solubility and stability of synthesized oligonucleotides, crucial for applications in diagnostics, therapeutics, and biochemical research.

CAT: BRP-01171

Molecular Formula: C57H71N2O7P

Molecular Weight: 927.18

Purity: ≥97% by UPLC

Appearance: White, off-white to light yellow powder

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InChIKey: YMXVZHWMLGEXDA-UHFFFAOYSA-N

CanonicalSMILES: CC(N(P(N(C(C)C)C(C)C)OC(COC(C1=CC=C(OC)C=C1)(C2=CC=C(OC)C=C2)C3=CC=CC=C3)COC(C4=CC=C(OC)C=C4)(C5=CC=C(OC)C=C5)C6=CC=CC=C6)C(C)C)C

IUPAC Name: 1-((1,3-bis(bis(4-methoxyphenyl)(phenyl)methoxy)propan-2-yl)oxy)-N,N,N',N'-tetraisopropylphosphanediamine

InChI: InChI=1S/C57H71N2O7P/c1-41(2)58(42(3)4)67(59(43(5)6)44(7)8)66-55(39-64-56(45-19-15-13-16-20-45,47-23-31-51(60-9)32-24-47)48-25-33-52(61-10)34-26-48)40-65-57(46-21-17-14-18-22-46,49-27-35-53(62-11)36-28-49)50-29-37-54(63-12)38-30-50/h13-38,41-44,55H,39-40H2,1-12H3

Synonyms: 1,3-di-O-(4,4'-dimethoxytrityl)-glycerol-bis-(diisopropylamino)-Phosphane

NHMMTr-C8 Phosphoramidite

Description: NHMMTr (N-methyl-N-(4-methoxy-2,4-dimethylphenyl)aminoethyl) linked to an octyl chain serves as a phosphoramidite for oligonucleotide synthesis. This modification improves the stability and hybridization properties of synthesized oligonucleotides, making them suitable for applications such as antisense therapy, gene silencing, and diagnostics.

CAT: BRP-01172

Molecular Formula: C37H52N3O3P

Molecular Weight: 617.81

Purity: ≥97% by UPLC

Appearance: Colorless to light yellow oily matter

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InChIKey: WQNVNSOXLICQQJ-UHFFFAOYSA-N

CanonicalSMILES: N#CCCOP(N(C(C)C)C(C)C)OCCCCCCCCNC(C1=CC=CC=C1)(C2=CC=C(OC)C=C2)C3=CC=CC=C3

IUPAC Name: 2-cyanoethyl (8-(((4-methoxyphenyl)diphenylmethyl)amino)octyl) diisopropylphosphoramidite

InChI: InChI=1S/C37H52N3O3P/c1-31(2)40(32(3)4)44(43-30-18-27-38)42-29-17-9-7-6-8-16-28-39-37(33-19-12-10-13-20-33,34-21-14-11-15-22-34)35-23-25-36(41-5)26-24-35/h10-15,19-26,31-32,39H,6-9,16-18,28-30H2,1-5H3

Synonyms: Monomethoxytrityl-octylamine-linker Phosphoramidite; MMTr C8 amine amidite

12-O-DMTr-dodecane-bis-(diisopropylamino)-Phosphane

Description: This phosphoramidite incorporates a dodecane spacer with two DMTr groups and diisopropylamino phosphane groups. It facilitates the attachment of nucleoside units during oligonucleotide synthesis, ensuring efficient coupling and high purity of the final product. The dodecane spacer provides flexibility and stability to synthesized oligonucleotides, essential for biomedical and research applications.

CAT: BRP-01173

Molecular Formula: C45H71N2O4P

Molecular Weight: 735.05

Purity: ≥97% by HPLC

Appearance: Colorless to light yellow oily matter

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InChIKey: RQZBDCUKNIMBGS-UHFFFAOYSA-N

CanonicalSMILES: CC(N(C(C)C)P(OCCCCCCCCCCCCOC(C1=CC=CC=C1)(C2=CC=C(OC)C=C2)C3=CC=C(C=C3)OC)N(C(C)C)C(C)C)C

IUPAC Name: 1-((12-(bis(4-methoxyphenyl)(phenyl)methoxy)dodecyl)oxy)-N,N,N',N'-tetraisopropylphosphanediamine

InChI: InChI=1S/C45H71N2O4P/c1-36(2)46(37(3)4)52(47(38(5)6)39(7)8)51-35-23-18-16-14-12-11-13-15-17-22-34-50-45(40-24-20-19-21-25-40,41-26-30-43(48-9)31-27-41)42-28-32-44(49-10)33-29-42/h19-21,24-33,36-39H,11-18,22-23,34-35H2,1-10H3

Synonyms: 12-O-(4,4'-dimethoxytrityl)-dodecane-bis-(diisopropylamino)-Phosphane

N-Butyl-2-cyanoethyl-N,N-diisopropylphosphoramidite

Description: This phosphoramidite derivative contains a butyl group, cyanoethyl protecting group, and diisopropylphosphoramidite functionality for coupling nucleoside units in oligonucleotide synthesis. It enhances the efficiency and specificity of nucleotide incorporation, enabling the synthesis of customized oligonucleotides for gene expression studies, RNA interference, and therapeutic applications.

CAT: BRP-01174

CAS: 887265-03-4

Molecular Formula: C13H27N2O2P

Molecular Weight: 274.34

Purity: >95%

Appearance: Colorless to light yellow oily matter

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InChIKey: IICOXFTVYLVMBH-UHFFFAOYSA-N

CanonicalSMILES: CCCCOP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: 3-[butoxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C13H27N2O2P/c1-6-7-10-16-18(17-11-8-9-14)15(12(2)3)13(4)5/h12-13H,6-8,10-11H2,1-5H3

Synonyms: Butyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, butyl 2-cyanoethyl ester; Butyl (2-cyanoethyl) diisopropylphosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, butyl 2-cyanoethyl ester

Cholesterol tetraethylene glycol (TetraEG) amidite

Description: Cholesterol linked to tetraethylene glycol (TetraEG) serves as an amidite for synthesizing cholesterol-conjugated oligonucleotides. This modification enhances cellular uptake and plasma stability of oligonucleotides, making them suitable for targeted delivery and therapeutic applications in treating cardiovascular diseases and metabolic disorders.

CAT: BRP-01175

CAS: 902153-15-5

Molecular Formula: C48H86N3O8P

Molecular Weight: 864.20

Purity: ≥97% by HPLC

Appearance: Colorless to faint yellow oily matter

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InChIKey: LWVRDTCTOJPCKR-UFMWMBMBSA-N

CanonicalSMILES: N#CCCOP(OCCOCCOCCOCCOCCCNC(=O)OC1CC2=CCC3C(CCC4(C)C(CCC34)C(C)CCCC(C)C)C2(C)CC1)N(C(C)C)C(C)C

IUPAC Name: (3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl (1-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-3,6,9,12-tetraoxapentadecan-15-yl)carbamate

InChI: InChI=1S/C48H86N3O8P/c1-36(2)13-10-14-39(7)43-17-18-44-42-16-15-40-35-41(19-21-47(40,8)45(42)20-22-48(43,44)9)59-46(52)50-24-12-25-53-27-28-54-29-30-55-31-32-56-33-34-58-60(57-26-11-23-49)51(37(3)4)38(5)6/h15,36-39,41-45H,10-14,16-22,24-35H2,1-9H3,(H,50,52)/t39-,41+,42+,43-,44+,45+,47+,48-,60?/m1/s1

Synonyms: Cholesterol tetraethylene glycol (TetraEG) amidite (plant source); Cholest-5-en-3-ol (3β)-, 19-[bis(1-methylethyl)amino]-22-cyano-6,9,12,15,18,20-hexaoxa-2-aza-19-phosphadocosanoate; Cholesterol (Plant) TEG CE phosphoramidite

5-O-DMTr-1-O-Bz-2-O-Me-ribofuranose-3-CE-Phosphoramidite

Description: This phosphoramidite is used in solid-phase synthesis of oligonucleotides where the ribofuranose sugar is modified with a dimethoxytrityl (DMTr) group on the 5'-hydroxyl, a benzoyl (Bz) group on the 1'-hydroxyl, and a methyl (Me) group on the 2'-position. These modifications provide stability and protection during synthesis, allowing for the creation of custom sequences for research and diagnostic applications.

CAT: BRP-01176

Molecular Formula: C43H51N2O9P

Molecular Weight: 770.85

Purity: ≥95% by UPLC

Appearance: White, off-white to light yellow powder

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InChIKey: DSCOSSQZAIEQAY-QXSSZZJWSA-N

IUPAC Name: (3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-3-methoxytetrahydrofuran-2-yl benzoate

InChI: InChI=1S/C43H51N2O9P/c1-30(2)45(31(3)4)55(51-28-14-27-44)54-39-38(52-42(40(39)49-7)53-41(46)32-15-10-8-11-16-32)29-50-43(33-17-12-9-13-18-33,34-19-23-36(47-5)24-20-34)35-21-25-37(48-6)26-22-35/h8-13,15-26,30-31,38-40,42H,14,28-29H2,1-7H3/t38-,39-,40-,42?,55?/m1/s1

Synonyms: 5-O-(4,4'-dimethoxytrityl)-1-O-benzoyl-2-O-methyl-ribofuranose-3-cyanoethyl Phosphoramidite

2,6-diamino(N2,N6-diPac)-DMT-2'-O-Me-purine riboside-CE-Phosphoramidite

Description: This phosphoramidite incorporates a purine nucleoside modified with a diPac (diphenoxyacetyl) group on the amino functionalities, a dimethoxytrityl (DMT) group on the 2'-hydroxyl of ribose. It is utilized in the synthesis of oligonucleotides where enhanced base pairing and stability are required, suitable for antisense technology and gene silencing applications.

CAT: BRP-01177

Molecular Formula: C57H63N8O11P

Molecular Weight: 1067.14

Purity: ≥98% by HPLC

Appearance: White to off-white powder

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InChIKey: GRQBYZJMCOKHGG-FDBJCFRMSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OC)N2C=NC3=C(N=C(N=C32)NC(=O)COC4=CC=CC=C4)NC(=O)COC5=CC=CC=C5)COC(C6=CC=CC=C6)(C7=CC=C(C=C7)OC)C8=CC=C(C=C8)OC

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-methoxyoxolan-2-yl]-2-[(2-phenoxyacetyl)amino]purin-6-yl]-2-phenoxyacetamide

InChI: InChI=1S/C57H63N8O11P/c1-38(2)65(39(3)4)77(74-33-17-32-58)76-51-47(34-73-57(40-18-11-8-12-19-40,41-24-28-43(68-5)29-25-41)42-26-30-44(69-6)31-27-42)75-55(52(51)70-7)64-37-59-50-53(60-48(66)35-71-45-20-13-9-14-21-45)62-56(63-54(50)64)61-49(67)36-72-46-22-15-10-16-23-46/h8-16,18-31,37-39,47,51-52,55H,17,33-36H2,1-7H3,(H2,60,61,62,63,66,67)/t47-,51-,52-,55-,77?/m1/s1

Synonyms: 2,6-Diamino-(N2,N6-diphenoxyacetyl)-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-purine riboside-3'-cyanoethyl phosphoramidite; (2R,3R,4R,5R)-5-(2,6-bis(2-phenoxyacetamido)-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; 2'-O-Methyl-2,6-diamino (N2,N6-diPAC)-purine-3'-CEP

5'-O-DMTr-2'-O-Me-A(iBu) PACE amidite

Description: This amidite contains an adenine nucleoside modified with a 5'-dimethoxytrityl (DMTr) group and a 2'-O-methyl (Me) group, suitable for solid-phase oligonucleotide synthesis. The iBu (isobutyryl) group enhances stability and compatibility during synthesis, ensuring efficient coupling and high purity of adenine-modified oligonucleotides.

CAT: BRP-01178

Molecular Formula: C49H62N7O9P

Molecular Weight: 924.05

Purity: ≥98% by HPLC

Appearance: White to pale yellow solid

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InChIKey: VIBUJWBMYBGTTQ-KMMWAEGCSA-N

IUPAC Name: 1-cyano-2-methylpropan-2-yl 2-((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(6-isobutyramido-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)acetate

InChI: InChI=1S/C49H62N7O9P/c1-31(2)46(58)54-44-41-45(52-29-51-44)55(30-53-41)47-43(61-11)42(65-66(56(32(3)4)33(5)6)28-40(57)64-48(7,8)25-26-50)39(63-47)27-62-49(34-15-13-12-14-16-34,35-17-21-37(59-9)22-18-35)36-19-23-38(60-10)24-20-36/h12-24,29-33,39,42-43,47H,25,27-28H2,1-11H3,(H,51,52,54,58)/t39-,42-,43-,47-,66?/m1/s1

Synonyms: 3'-O-(Diisopropylamino)phosphinoacetic acid α,α-dimethyl-β-cyanoethyl methyl ester N6-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyladenosine; 5'-O-DMTr-2'-O-Me-A(iBu) PACE; 5'-O-DMTr-2'-O-Me-A(iBu) PACE Phosphoramidite

5'-O-DMTr-2'-O-Me-G(Ac) PACE amidite

Description: This amidite incorporates a guanine nucleoside modified with a 5'-dimethoxytrityl (DMTr) group and a 2'-O-methyl (Me) group, along with an acetyl (Ac) group at the base. It is used in oligonucleotide synthesis to introduce modified guanine residues, offering versatility in structure and function studies of nucleic acids.

CAT: BRP-01179

Molecular Formula: C47H58N7O10P

Molecular Weight: 911.99

Purity: ≥98% by HPLC

Appearance: White to pale yellow solid

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InChIKey: QQXUTIPUYDMWLY-JONXRGCJSA-N

IUPAC Name: 1-cyano-2-methylpropan-2-yl 2-((((2R,3R,4R,5R)-5-(2-acetamido-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)acetate

InChI: InChI=1S/C47H58N7O10P/c1-29(2)54(30(3)4)65(27-38(56)63-46(6,7)24-25-48)64-40-37(62-44(41(40)60-10)53-28-49-39-42(53)51-45(50-31(5)55)52-43(39)57)26-61-47(32-14-12-11-13-15-32,33-16-20-35(58-8)21-17-33)34-18-22-36(59-9)23-19-34/h11-23,28-30,37,40-41,44H,24,26-27H2,1-10H3,(H2,50,51,52,55,57)/t37-,40-,41-,44-,65?/m1/s1

Synonyms: 3'-O-(Diisopropylamino)phosphinoacetic acid α,α-dimethyl-β-cyanoethyl methyl ester N2-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methylguanosine; 5'-O-DMTr-2'-O-Me-G(Ac) PACE; 5'-O-DMTr-2'-O-Me-G(Ac) PACE Phosphoramidite

Morpholino A(Ceoc) subunit

Description: This subunit consists of a morpholino ring (a six-membered morpholine ring) modified with a Ceoc group attached to an adenine base. Morpholinos are synthetic nucleic acid analogs used primarily as antisense agents to block gene expression by binding to complementary RNA sequences, offering potential therapeutic applications in gene regulation and disease treatment.

CAT: BRP-01180

Molecular Formula: C35H36ClN8O5P

Molecular Weight: 715.15

Purity: ≥98% by UPLC

Appearance: White, off-white to light yellow powder

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InChIKey: AELIKKSXAYGGHK-YYNRDWDXSA-N

IUPAC Name: 2-cyanoethyl (9-((2R,6S)-6-(((chloro(dimethylamino)phosphoryl)oxy)methyl)-4-tritylmorpholin-2-yl)-9H-purin-6-yl)carbamate

InChI: InChI=1S/C35H36ClN8O5P/c1-42(2)50(36,46)48-23-29-21-43(35(26-13-6-3-7-14-26,27-15-8-4-9-16-27)28-17-10-5-11-18-28)22-30(49-29)44-25-40-31-32(38-24-39-33(31)44)41-34(45)47-20-12-19-37/h3-11,13-18,24-25,29-30H,12,20-23H2,1-2H3,(H,38,39,41,45)/t29-,30+,50?/m0/s1

Synonyms: 2-cyanoethyl (9-(6-(((chloro(dimethylamino)phosphoryl)oxy)methyl)-4-tritylmorpholin-2-yl)-9H-purin-6-yl)carbamate

Morpholino C(Ceoc) subunit

Description: This variant features a morpholino ring modified with a Ceoc group linked to a cytosine base. It serves similar purposes as the A(Ceoc) subunit in antisense technology, facilitating selective binding to RNA targets for gene knockdown and therapeutic interventions.

CAT: BRP-01181

Molecular Formula: C34H36ClN6O6P

Molecular Weight: 691.12

Purity: ≥98% by UPLC

Appearance: White, off-white to light yellow powder

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Storage: Store at -20 °C

InChIKey: NNFJEBJVHVPSJG-HYZMJWPCSA-N

IUPAC Name: 2-cyanoethyl (1-((2R,6S)-6-(((chloro(dimethylamino)phosphoryl)oxy)methyl)-4-tritylmorpholin-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)carbamate

InChI: InChI=1S/C34H36ClN6O6P/c1-39(2)48(35,44)46-25-29-23-40(24-31(47-29)41-21-19-30(37-32(41)42)38-33(43)45-22-12-20-36)34(26-13-6-3-7-14-26,27-15-8-4-9-16-27)28-17-10-5-11-18-28/h3-11,13-19,21,29,31H,12,22-25H2,1-2H3,(H,37,38,42,43)/t29-,31+,48?/m0/s1

Synonyms: 2-cyanoethyl (1-(6-(((chloro(dimethylamino)phosphoryl)oxy)methyl)-4-tritylmorpholin-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)carbamate

Boc-PNA-C(Z)-OH

Description: Boc-PNA-C(Z)-OH is a synthetic peptide nucleic acid (PNA) monomer with a cytosine base. It features a BOC (tert-butyloxycarbonyl) protecting group and a Z (benzyloxycarbonyl) group. This monomer is utilized in the synthesis of PNA oligomers for molecular biology and genetic research, particularly in the study of DNA and RNA interactions and hybridization.

CAT: BRP-01182

CAS: 144564-94-3

Molecular Formula: C23H29N5O8

Molecular Weight: 503.51

Purity: ≥97% by HPLC

Appearance: White, off-white to faint yellow powder

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Storage: Store at 2-8 °C, in tightly closed container, protected from light and humidity

Density: 1.32±0.1 g/cm3

Melting Point: 156 °C (dec.)

InChIKey: UCPRPVFFEVZHEJ-UHFFFAOYSA-N

CanonicalSMILES: CC(C)(C)OC(=O)NCCN(CC(=O)O)C(=O)CN1C=CC(=NC1=O)NC(=O)OCC2=CC=CC=C2

IUPAC Name: 2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethyl-[2-[2-oxo-4-(phenylmethoxycarbonylamino)pyrimidin-1-yl]acetyl]amino]acetic acid

InChI: InChI=1S/C23H29N5O8/c1-23(2,3)36-21(33)24-10-12-27(14-19(30)31)18(29)13-28-11-9-17(25-20(28)32)26-22(34)35-15-16-7-5-4-6-8-16/h4-9,11H,10,12-15H2,1-3H3,(H,24,33)(H,30,31)(H,25,26,32,34)

Synonyms: N-((N4-(benzyloxycarbonyl)cytosine-9-yl)acetyl)-N-(2-Boc-aminoethyl)glycine; N-[2-[[(1,1-Dimethylethoxy)carbonyl]amino]ethyl]-N-[2-[2-oxo-4-[[(phenylmethoxy)carbonyl]amino]-1(2H)-pyrimidinyl]acetyl]glycine; 2-(2-(4-(benzyloxycarbonylamino)-2-oxopyrimidin-1(2H)-yl)-N-(2-(tert-butoxycarbonylamino) ethyl)acetamido)acetic acid; Boc-Aeg(C[z])-OH

Boc-PNA-A(Z)-OH

Description: Boc-PNA-A(Z)-OH is a synthetic peptide nucleic acid (PNA) monomer with an adenine base. It features a Boc (tert-butyloxycarbonyl) protecting group and a Z (benzyloxycarbonyl) group. This monomer is used in the synthesis of PNA oligomers for research in molecular biology and genetics, particularly for studying DNA and RNA binding and hybridization.

CAT: BRP-01183

CAS: 149376-69-2

Molecular Formula: C24H29N7O7

Molecular Weight: 527.53

Purity: ≥97% by HPLC

Appearance: White, off-white to faint yellow powder

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Storage: Store at 2-8 °C, in tightly closed container, protected from light and humidity

Density: 1.38±0.1 g/cm3

Melting Point: 119 °C (dec.)

InChIKey: HNSNKXSLRGSKQN-UHFFFAOYSA-N

CanonicalSMILES: CC(C)(C)OC(=O)NCCN(CC(=O)O)C(=O)CN1C=NC2=C(N=CN=C21)NC(=O)OCC3=CC=CC=C3

IUPAC Name: 2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethyl-[2-[6-(phenylmethoxycarbonylamino)purin-9-yl]acetyl]amino]acetic acid

InChI: InChI=1S/C24H29N7O7/c1-24(2,3)38-22(35)25-9-10-30(12-18(33)34)17(32)11-31-15-28-19-20(26-14-27-21(19)31)29-23(36)37-13-16-7-5-4-6-8-16/h4-8,14-15H,9-13H2,1-3H3,(H,25,35)(H,33,34)(H,26,27,29,36)

Synonyms: N-((N6-(benzyloxycarbonyl)adenin-9-yl)acetyl)-N-(2-Boc-aminoethyl)glycine; N-(2-(6-(((Benzyloxy)carbonyl)amino)-9H-purin-9-yl)acetyl)-N-(2-((tert-butoxycarbonyl)amino)ethyl)glycine; N-[2-[[(1,1-Dimethylethoxy)carbonyl]amino]ethyl]-N-[2-[6-[[(phenylmethoxy)carbonyl]amino]-9H-purin-9-yl]acetyl]glycine

N1-Me-5'-O-DMTr-2'-O-TBDMS-G(dmf)-3'-CE-Phosphoramidite

Description: This phosphoramidite consists of a guanosine nucleoside modified with N1-methyl (N1-Me), 5'-dimethoxytrityl (DMTr), 2'-O-tert-butyldimethylsilyl (TBDMS), and a dmf (dimethylformamide) group linked to the base. It is used in solid-phase synthesis to introduce modified guanosine residues into oligonucleotides, providing stability and compatibility during synthesis.

CAT: BRP-01184

Molecular Formula: C50H69N8O8PSi

Molecular Weight: 969.21

Purity: ≥97% by HPLC

Appearance: White, off-white to light yellow powder

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InChIKey: VNPNGTSSGZPPHO-PGKNMGFDSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C(=O)N(C(N=CN(C)C)=NC32)C)C1O[Si](C)(C)C(C)(C)C)COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2-(((dimethylamino)methylene)amino)-1-methyl-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C50H69N8O8PSi/c1-34(2)58(35(3)4)67(63-30-18-29-51)65-43-41(31-62-50(36-19-16-15-17-20-36,37-21-25-39(60-11)26-22-37)38-23-27-40(61-12)28-24-38)64-47(44(43)66-68(13,14)49(5,6)7)57-33-52-42-45(57)54-48(53-32-55(8)9)56(10)46(42)59/h15-17,19-28,32-35,41,43-44,47H,18,30-31H2,1-14H3/t41-,43-,44-,47-,67?/m1/s1

Synonyms: N1-methyl-N2-dimethylformamide-5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyl-dimethylsilyl)-guanosine-3'-cyanoethyl Phosphoramidite

5'-O-DMT-2'-O-TBDMS-G(Me)-3'-CE-Phosphoramidite

Description: This phosphoramidite contains a guanosine nucleoside modified with a 5'-dimethoxytrityl (DMT) group, a 2'-O-tert-butyldimethylsilyl (TBDMS) group, and a methyl (Me) group. It is utilized in oligonucleotide synthesis to incorporate guanine modifications, offering enhanced stability and specificity in nucleic acid interactions.

CAT: BRP-01185

Molecular Formula: C47H64N7O8PSi

Molecular Weight: 914.13

Purity: ≥97% by UPLC

Appearance: White, off-white to light yellow powder

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InChIKey: RNYXUWAQJPNBRD-SLLDXECHSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2-(methylamino)-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C47H64N7O8PSi/c1-31(2)54(32(3)4)63(59-28-16-27-48)61-40-38(60-44(41(40)62-64(11,12)46(5,6)7)53-30-50-39-42(53)51-45(49-8)52-43(39)55)29-58-47(33-17-14-13-15-18-33,34-19-23-36(56-9)24-20-34)35-21-25-37(57-10)26-22-35/h13-15,17-26,30-32,38,40-41,44H,16,28-29H2,1-12H3,(H2,49,51,52,55)/t38-,40-,41-,44-,63?/m1/s1

Synonyms: N2-methyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyl-dimethylsilyl)-guanosine-3'-cyanoethyl Phosphoramidite; 5'-O-DMT-2'-O-TBDMS-dG(Me)-3'-CE-Phosphoramidite

N1-Me-5'-O-DMTr-2'-O-TBDMS-G(iPr-pac)-3'-CE-Phosphoramidite

Description: This phosphoramidite features a guanosine nucleoside with N1-methyl (N1-Me), 5'-dimethoxytrityl (DMTr), 2'-O-tert-butyldimethylsilyl (TBDMS), and isopropylphenoxyacetyl (iPr-Pac)-protected phosphoramidite groups. It is employed in oligonucleotide synthesis to introduce modified guanine residues, enhancing stability and functionality for various biomedical and research applications.

CAT: BRP-01186

Molecular Formula: C58H76N7O10PSi

Molecular Weight: 1090.34

Purity: ≥97% by UPLC

Appearance: White, off-white to light yellow powder

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Storage: Store at -20 °C

InChIKey: FDSKQAUYTVNZJK-YCBNDBQVSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2-(2-(4-isopropylphenoxy)acetamido)-1-methyl-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C58H76N7O10PSi/c1-38(2)41-21-27-47(28-22-41)70-36-49(66)61-56-62-53-50(54(67)63(56)10)60-37-64(53)55-52(75-77(13,14)57(7,8)9)51(74-76(72-34-18-33-59)65(39(3)4)40(5)6)48(73-55)35-71-58(42-19-16-15-17-20-42,43-23-29-45(68-11)30-24-43)44-25-31-46(69-12)32-26-44/h15-17,19-32,37-40,48,51-52,55H,18,34-36H2,1-14H3,(H,61,62,66)/t48-,51-,52-,55-,76?/m1/s1

Synonyms: N1-methyl-N2-(p-isopropyl-phenoxyacetyl)-5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyl-dimethylsilyl)-guanosine-3'-cyanoethyl Phosphoramidite

2'-O-TBDMS-5'-trifluoroacetamido-U-3'-CE-Phosphoramidite

Description: This phosphoramidite contains a uridine nucleoside modified with a 2'-O-tert-butyldimethylsilyl (TBDMS) group and a 5'-trifluoroacetamido (TFA) group. It is used in oligonucleotide synthesis to incorporate modified uridine residues, providing enhanced stability and specific interactions in nucleic acid hybridization studies and therapeutic applications.

CAT: BRP-01187

Molecular Formula: C26H43F3N5O7PSi

Molecular Weight: 653.70

Purity: ≥97% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: JJJISHQDDQBWAN-OJHMZDIXSA-N

IUPAC Name: (2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-((2,2,2-trifluoroacetamido)methyl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C26H43F3N5O7PSi/c1-16(2)34(17(3)4)42(38-14-10-12-30)40-20-18(15-31-23(36)26(27,28)29)39-22(33-13-11-19(35)32-24(33)37)21(20)41-43(8,9)25(5,6)7/h11,13,16-18,20-22H,10,14-15H2,1-9H3,(H,31,36)(H,32,35,37)/t18-,20-,21-,22-,42?/m1/s1

Synonyms: 2'-O-(t-butyl-dimethylsilyl)-5'-trifluoroacetamido-uridine-3'-[(2-cyanoethyl)-N,N-diisopropyl] phosphoramidite

2-Cyanoethyl (6-(3-(prop-2-yn-1-yloxy)-2,2-bis((prop-2-yn-1-yloxy)methyl)propoxy)hexyl) diisopropylphosphoramidite

TEG-GalNAc Cluster Amidite

DMTr-hydroxymethyl hexyl-Biotin Phosphoramidite

1,3-di-O-DMTr-glycerol-bis-(diisopropylamino)-Phosphane

NHMMTr-C8 Phosphoramidite

12-O-DMTr-dodecane-bis-(diisopropylamino)-Phosphane

N-Butyl-2-cyanoethyl-N,N-diisopropylphosphoramidite

Cholesterol tetraethylene glycol (TetraEG) amidite

5-O-DMTr-1-O-Bz-2-O-Me-ribofuranose-3-CE-Phosphoramidite

2,6-diamino(N2,N6-diPac)-DMT-2'-O-Me-purine riboside-CE-Phosphoramidite

5'-O-DMTr-2'-O-Me-A(iBu) PACE amidite

5'-O-DMTr-2'-O-Me-G(Ac) PACE amidite

Morpholino A(Ceoc) subunit

Morpholino C(Ceoc) subunit

Boc-PNA-C(Z)-OH

Boc-PNA-A(Z)-OH

N1-Me-5'-O-DMTr-2'-O-TBDMS-G(dmf)-3'-CE-Phosphoramidite

5'-O-DMT-2'-O-TBDMS-G(Me)-3'-CE-Phosphoramidite

N1-Me-5'-O-DMTr-2'-O-TBDMS-G(iPr-pac)-3'-CE-Phosphoramidite

2'-O-TBDMS-5'-trifluoroacetamido-U-3'-CE-Phosphoramidite

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