Phosphoramidites - RNA / BOC Sciences

2'-OTBS 5-PivOM-U amidite

Description: 2'-OTBS 5-PivOM-U amidite is a reagent used in oligonucleotide synthesis. This reagent contains a modification at the 2' position of ribose with 2'-O-tert-butyldimethylsilyl (OTBS) and incorporates 5-PivOM-Uridine (5-PivOM-U), a modified uridine nucleoside with a 5'-O-(pivaloyloxymethyl) (PivOM) protecting group attached at the 5-position of the uracil base. It enables the synthesis of oligonucleotides containing 5-PivOM-Uridine modifications, which can be useful for various applications in oligonucleotide chemistry and nucleic acid research.

CAT: BRP-00979

CAS: 2087953-37-3

MF: C51H71N4O11PSi

MF: 975.21

Purity: >95%

Appearance: Off-white solid

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InChIKey: DJJDOAIVIHEKMZ-GXXQHJQMSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=C(C(=O)NC2=O)COC(=O)C(C)(C)C)C1O[Si](C)(C)C(C)(C)C)COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)N(C(C)C)C(C)C

IUPAC Name: (1-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)tetrahydrofuran-2-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl pivalate

InChI: InChI=1S/C51H71N4O11PSi/c1-34(2)55(35(3)4)67(63-30-18-29-52)65-43-42(33-62-51(37-19-16-15-17-20-37,38-21-25-40(59-11)26-22-38)39-23-27-41(60-12)28-24-39)64-46(44(43)66-68(13,14)50(8,9)10)54-31-36(45(56)53-48(54)58)32-61-47(57)49(5,6)7/h15-17,19-28,31,34-35,42-44,46H,18,30,32-33H2,1-14H3,(H,53,56,58)/t42-,43-,44-,46-,67?/m1/s1

2'-OTBS 5-(3''-amino(TFA)-propynyl)-U amidite

Description: 2'-OTBS 5-(3''-amino(TFA)-propynyl)-U amidite is a reagent used in oligonucleotide synthesis. This reagent contains a modification at the 2' position of ribose with 2'-O-tert-butyldimethylsilyl (OTBS) and incorporates 5-(3''-amino(TFA)-propynyl)-Uridine, which consists of a propynyl linker with an amino group modified with trifluoroacetic acid (TFA) protection, attached at the 5-position of the uracil base. It allows for the synthesis of oligonucleotides containing this specific modification, which can be useful for various applications such as conjugation, labeling, or functionalization of oligonucleotides.

CAT: BRP-00980

CAS: 1269413-23-1

MF: C50H63F3N5O10PSi

MF: 1010.13

Purity: >95%

Appearance: Off-white solid

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InChIKey: WJZHTBADFQJCHH-UETLZWTDSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=C(C#CCNC(=O)C(F)(F)F)C(=O)NC2=O)C1O[Si](C)(C)C(C)(C)C)COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2,4-dioxo-5-(3-(2,2,2-trifluoroacetamido)prop-1-yn-1-yl)-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C50H63F3N5O10PSi/c1-33(2)58(34(3)4)69(65-30-16-28-54)67-42-41(32-64-49(36-18-13-12-14-19-36,37-20-24-39(62-8)25-21-37)38-22-26-40(63-9)27-23-38)66-45(43(42)68-70(10,11)48(5,6)7)57-31-35(44(59)56-47(57)61)17-15-29-55-46(60)50(51,52)53/h12-14,18-27,31,33-34,41-43,45H,16,29-30,32H2,1-11H3,(H,55,60)(H,56,59,61)/t41-,42-,43-,45-,69?/m1/s1

Synonyms: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-5-[3-[(2,2,2-trifluoroacetyl)amino]-1-propyn-1-yl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

2'-OMe N3-Bz-U amidite

Description: 2'-OMe N3-Bz-U amidite is a reagent used in oligonucleotide synthesis. This reagent contains a modification at the 2' position of ribose with 2'-O-methyl (OMe) and incorporates N3-Benzoyl-Uridine (N3-Bz-U), a modified uridine nucleoside with a benzoyl group (Bz) attached at the N3 position of the uracil base. It enables the synthesis of oligonucleotides containing N3-Benzoyl-Uridine modifications, which can impart specific properties or functionalities to the resulting oligonucleotides, useful for various biotechnological applications.

CAT: BRP-00981

CAS: 178422-03-2

MF: C47H53N4O10P

MF: 864.93

Purity: >98%

Appearance: Off-white solid

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InChIKey: RLZUETJITSYKAT-VKBHKTMGSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OC)N2C=CC(=O)N(C2=O)C(=O)C3=CC=CC=C3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: 3-[[(2R,3R,4R,5R)-5-(3-benzoyl-2,4-dioxopyrimidin-1-yl)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-methoxyoxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C47H53N4O10P/c1-32(2)51(33(3)4)62(59-30-14-28-48)61-42-40(60-45(43(42)57-7)49-29-27-41(52)50(46(49)54)44(53)34-15-10-8-11-16-34)31-58-47(35-17-12-9-13-18-35,36-19-23-38(55-5)24-20-36)37-21-25-39(56-6)26-22-37/h8-13,15-27,29,32-33,40,42-43,45H,14,30-31H2,1-7H3/t40-,42-,43-,45-,62?/m1/s1

Synonyms: N3-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyluridine-3'-cyanoethyl phosphoramidite; (2R,3R,4R,5R)-5-(3-benzoyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; Uridine, 3-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[2-cyanoethyl [bis(1-methylethyl)amino]phosphoramidite]; DMT-2'-O-Me-U(Bz)-CE-Phosphoramidite

5'-O-DMTr-2'-OMe-C(Ac)-3'-Methoxy-phosphoramidite

Description: 5'-O-DMTr-2'-OMe-C(Ac)-3'-Methoxy-phosphoramidite is a reagent used in oligonucleotide synthesis. It features a dimethoxytrityl (DMTr) protecting group at the 5' hydroxyl, a cytosine nucleoside modified with 2'-O-methyl (OMe) and acetyl (Ac) protection, and a methoxy group at the 3' position of the phosphoramidite. This reagent enables controlled synthesis of oligonucleotides with specific modifications, crucial for various applications in molecular biology and nucleic acid research.

CAT: BRP-00982

MF: C40H51N4O9P

MF: 762.84

Purity: ≥98% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: NHLKBIREBJIEBF-XKZJCBTISA-N

IUPAC Name: (2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl methyl diisopropylphosphoramidite

InChI: InChI=1S/C40H51N4O9P/c1-26(2)44(27(3)4)54(50-9)53-36-34(52-38(37(36)49-8)43-24-23-35(41-28(5)45)42-39(43)46)25-51-40(29-13-11-10-12-14-29,30-15-19-32(47-6)20-16-30)31-17-21-33(48-7)22-18-31/h10-24,26-27,34,36-38H,25H2,1-9H3,(H,41,42,45,46)/t34-,36-,37-,38-,54?/m1/s1

Synonyms: N4-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-cytidine-3'-Methoxy-phosphoramidite; 2'-OMe C(Ac) OMe-amidite

5'-O-DMTr-2'-O-MOE-5-Me-U-3'-Methoxy-phosphoramidite

Description: 5'-O-DMTr-2'-O-MOE-5-Me-U-3'-Methoxy-phosphoramidite is a reagent used in oligonucleotide synthesis. It contains a dimethoxytrityl (DMTr) protecting group at the 5' hydroxyl, a 2'-O-methoxyethyl (MOE) modification, a 5-Methyl-Uridine (5-Me-U), and a methoxy group at the 3' position of the phosphoramidite. This reagent facilitates the synthesis of oligonucleotides with specific modifications, which can influence stability, hybridization properties, or enzymatic resistance of the resulting oligonucleotides.

CAT: BRP-00983

CAS: 674798-37-9

MF: C41H54N3O10P

MF: 779.87

Purity: ≥98% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: MGCBWJZQSWUFBV-VNZAIEIISA-N

CanonicalSMILES: O=C1NC(=O)N(C=C1C)C2OC(COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)C(OP(OC)N(C(C)C)C(C)C)C2OCCOC

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl methyl diisopropylphosphoramidite

InChI: InChI=1S/C41H54N3O10P/c1-27(2)44(28(3)4)55(50-9)54-36-35(53-39(37(36)51-24-23-47-6)43-25-29(5)38(45)42-40(43)46)26-52-41(30-13-11-10-12-14-30,31-15-19-33(48-7)20-16-31)32-17-21-34(49-8)22-18-32/h10-22,25,27-28,35-37,39H,23-24,26H2,1-9H3,(H,42,45,46)/t35-,36-,37-,39-,55?/m1/s1

Synonyms: 5'-O-(4,4'-dimethoxytrityl)-2'-O-methoxyethyl-5-methyl-uridine-3'-Methoxy-phosphoramidite; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-5-methyl-, 3'-[methyl bis(1-methylethyl)phosphoramidite]; 2'-MOE-5-Me-U OMe-amidite

5'-O-DMTr-2'-O-MOE-G(iBu)-3'-Methoxy-phosphoramidite

Description: 5'-O-DMTr-2'-O-MOE-G(iBu)-3'-Methoxy-phosphoramidite is a reagent used in oligonucleotide synthesis. It contains a dimethoxytrityl (DMTr) protecting group at the 5' hydroxyl, a 2'-O-methoxyethyl (MOE) modification, a guanosine nucleoside with an isobutyl (iBu) protecting group, and a methoxy group at the 3' position of the phosphoramidite. This reagent enables the synthesis of oligonucleotides with specific modifications, which can affect stability, hybridization properties, or enzymatic resistance of the resulting oligonucleotides.

CAT: BRP-00984

MF: C45H59N6O10P

MF: 874.97

Purity: ≥98% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: RLSHXUDUUUJCEZ-MLLDKZSOSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl methyl diisopropylphosphoramidite

InChI: InChI=1S/C45H59N6O10P/c1-28(2)41(52)48-44-47-40-37(42(53)49-44)46-27-50(40)43-39(58-25-24-54-7)38(61-62(57-10)51(29(3)4)30(5)6)36(60-43)26-59-45(31-14-12-11-13-15-31,32-16-20-34(55-8)21-17-32)33-18-22-35(56-9)23-19-33/h11-23,27-30,36,38-39,43H,24-26H2,1-10H3,(H2,47,48,49,52,53)/t36-,38-,39-,43-,62?/m1/s1

Synonyms: N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methoxyethyl-guanosine-3'-Methoxy-phosphoramidite; 2'-MOE G(iBu) OMe-amidite

5'-O-DMTr-2'-O-MOE-C(Ac)-3'-Methoxy-phosphoramidite

Description: 5'-O-DMTr-2'-O-MOE-C(Ac)-3'-Methoxy-phosphoramidite is a reagent used in oligonucleotide synthesis. It features a dimethoxytrityl (DMTr) protecting group at the 5' hydroxyl, a 2'-O-methoxyethyl (MOE) modification, a cytosine nucleoside with acetyl (Ac) protection, and a methoxy group at the 3' position of the phosphoramidite. This reagent enables the controlled synthesis of oligonucleotides with specific modifications, crucial for various applications in molecular biology, diagnostics, and therapeutics.

CAT: BRP-00985

MF: C42H55N4O10P

MF: 806.89

Purity: ≥98% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: XQAZBBGGZWBTGL-UAQIPLLRSA-N

IUPAC Name: (2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl methyl diisopropylphosphoramidite

InChI: InChI=1S/C42H55N4O10P/c1-28(2)46(29(3)4)57(52-9)56-38-36(55-40(39(38)53-26-25-49-6)45-24-23-37(43-30(5)47)44-41(45)48)27-54-42(31-13-11-10-12-14-31,32-15-19-34(50-7)20-16-32)33-17-21-35(51-8)22-18-33/h10-24,28-29,36,38-40H,25-27H2,1-9H3,(H,43,44,47,48)/t36-,38-,39-,40-,57?/m1/s1

Synonyms: N4-acetyl-5-methyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methoxyethyl-cytidine-3'-Methoxy-phosphoramidite; 2'-MOE C(Ac) OMe-amidite

TEG-GalNAc Cluster Succinate

Description: TEG-GalNAc Cluster Succinate refers to a molecular structure consisting of multiple units of N-acetylgalactosamine (GalNAc) linked together with a succinate linker and spaced by triethylene glycol (TEG) units. This compound is utilized in chemical biology and medicinal chemistry for targeted delivery and therapeutic applications. The TEG units provide flexibility and solubility, while the GalNAc units serve as ligands for specific cellular receptors, often overexpressed in diseases like cancer and viral infections. The succinate linker facilitates conjugation to various molecules, enhancing the compound's versatility in drug delivery systems and glycoengineering.

CAT: BRP-01102

MF: C56H76N2O21

MF: 1113.22

Purity: ≥97% by HPLC

Appearance: White, off-white to light yellow powder

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InChIKey: CSPFAUDYIFCPFQ-ZFUKUOGASA-N

IUPAC Name: 26-(((2R,3R,4R,5R,6R)-3-acetamido-4,5-diacetoxy-6-(acetoxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-6-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4,22-dioxo-5,8,11,14,17-pentaoxa-21-azahexacosanoic acid

InChI: InChI=1S/C56H76N2O21/c1-38(59)58-52-54(77-41(4)62)53(76-40(3)61)48(37-74-39(2)60)79-55(52)73-28-11-10-15-49(63)57-26-12-27-69-29-30-70-31-32-71-33-34-72-35-47(78-51(66)25-24-50(64)65)36-75-56(42-13-8-7-9-14-42,43-16-20-45(67-5)21-17-43)44-18-22-46(68-6)23-19-44/h7-9,13-14,16-23,47-48,52-55H,10-12,15,24-37H2,1-6H3,(H,57,63)(H,58,59)(H,64,65)/t47?,48-,52-,53+,54-,55-/m1/s1

GalNAc-Cluster-COONa

Description: GalNAc-Cluster-COONa consists of a cluster of N-acetylgalactosamine units with a sodium carboxylate group. It may serve as a glycosylation agent or a targeting moiety in drug delivery systems aimed at cells expressing lectins that recognize GalNAc residues.

CAT: BRP-01103

CAS: 2071642-83-4

MF: C60H106N7NaO33

MF: 1476.51

Purity: ≥95% by HPLC

Appearance: White to off-white powder

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InChIKey: RPMTWBMBGZQLMO-QJLMKPIESA-M

CanonicalSMILES: [Na].O=C(O)C(NC(=O)C(NC(=O)COCCOCCOCCOC1OC(CO)C(O)C(O)C1NC(=O)C)CCCCNC(=O)COCCOCCOCCOC2OC(CO)C(O)C(O)C2NC(=O)C)CCCCNC(=O)COCCOCCOCCOC3OC(CO)C(O)C(O)C3NC(=O)C

IUPAC Name: sodium;(17S,20S)-1-(((2R,3R,4R,5R,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-20-(1-(((2R,3R,4R,5R,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-11-oxo-3,6,9-trioxa-12-azahexadecan-16-yl)-17-(2-(2-(2-(2-(((2R,3R,4R,5R,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethoxy)acetamido)-11,18-dioxo-3,6,9-trioxa-12,19-diazahenicosan-21-oate

InChI: InChI=1S/C60H107N7O33.Na/c1-36(71)63-47-53(80)50(77)41(30-68)98-58(47)95-27-24-89-15-12-86-18-21-92-33-44(74)61-10-6-4-8-39(66-46(76)35-94-23-20-88-14-17-91-26-29-97-60-49(65-38(3)73)55(82)52(79)43(32-70)100-60)56(83)67-40(57(84)85)9-5-7-11-62-45(75)34-93-22-19-87-13-16-90-25-28-96-59-48(64-37(2)72)54(81)51(78)42(31-69)99-59;/h39-43,47-55,58-60,68-70,77-82H,4-35H2,1-3H3,(H,61,74)(H,62,75)(H,63,71)(H,64,72)(H,65,73)(H,66,76)(H,67,83)(H,84,85);/q;+1/p-1/t39-,40-,41+,42+,43+,47+,48+,49+,50-,51-,52-,53+,54+,55+,58+,59+,60+;/m0./s1

Synonyms: N2,N6-Bis[2-[2-[2-[2-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]ethoxy]ethoxy]ethoxy]acetyl]-L-lysyl-N6-[2-[2-[2-[2-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]ethoxy]ethoxy]ethoxy]acetyl]-L-lysine sodium salt

Related CAS: 1332358-22-1 (free acid)

DFA-AH Linker Amidite

Description: DFA-AH Linker Amidite is a phosphoramidite derivative used in solid-phase synthesis of oligonucleotides. It incorporates a DFA-AH linker, enabling the attachment of labels, modifications, or functional groups for various biological and chemical applications.

CAT: BRP-01105

MF: C17H32F2N3O3P

MF: 395.42

Purity: ≥97% by HPLC

Appearance: Colorless to pale yellow oily matter

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InChIKey: NNGLSNYEFLFIIB-UHFFFAOYSA-N

CanonicalSMILES: CC(N(C(C)C)P(OCCC#N)OCCCCCCNC(C(F)F)=O)C

IUPAC Name: 2-cyanoethyl (6-(2,2-difluoroacetamido)hexyl) diisopropylphosphoramidite

InChI: InChI=1S/C17H32F2N3O3P/c1-14(2)22(15(3)4)26(25-13-9-10-20)24-12-8-6-5-7-11-21-17(23)16(18)19/h14-16H,5-9,11-13H2,1-4H3,(H,21,23)

Phenylacetyl HA amidite linker

Description: Phenylacetyl HA amidite linker is a phosphoramidite used in oligonucleotide synthesis to introduce a phenylacetyl linker. This linker can be utilized for conjugation or modification purposes, enhancing the oligonucleotide's properties for specific applications.

CAT: BRP-01106

MF: C23H38N3O3P

MF: 435.54

Purity: ≥95% by HPLC

Appearance: Colorless to faint yellow oily matter

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InChIKey: QQAXWXFCULHDFZ-UHFFFAOYSA-N

CanonicalSMILES: CC(N(C(C)C)P(OCCC#N)OCCCCCCNC(CC1=CC=CC=C1)=O)C

IUPAC Name: 2-cyanoethyl (6-(2-phenylacetamido)hexyl) diisopropylphosphoramidite

InChI: InChI=1S/C23H38N3O3P/c1-20(2)26(21(3)4)30(29-18-12-15-24)28-17-11-6-5-10-16-25-23(27)19-22-13-8-7-9-14-22/h7-9,13-14,20-21H,5-6,10-12,16-19H2,1-4H3,(H,25,27)

1-O-DMTr-Glycerol-TEG-Cholesterol-2-CE-Phosphoramidite

Description: This complex phosphoramidite derivative is used in solid-phase synthesis to introduce a glycerol-TEG-cholesterol linker with a 2-cyanoethyl (2-CE) protecting group at the 2' position of ribose. It is employed to modify oligonucleotides for enhanced stability, cellular uptake, or targeted delivery in gene therapy and drug development.

CAT: BRP-01107

MF: C68H103N2O10P

MF: 1139.55

Purity: ≥98% by HPLC

Appearance: Colorless to faint yellow oily matter

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InChIKey: ICUVMFZDOBVYKJ-JVGOCSKKSA-N

IUPAC Name: 2-cyanoethyl (17-(((3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)-1,1-bis(4-methoxyphenyl)-1-phenyl-2,6,9,12,15-pentaoxaheptadecan-4-yl) diisopropylphosphoramidite

InChI: InChI=1S/C68H103N2O10P/c1-50(2)17-15-18-53(7)63-31-32-64-62-30-25-57-47-60(33-35-66(57,8)65(62)34-36-67(63,64)9)77-46-45-75-42-41-73-39-40-74-43-44-76-48-61(80-81(79-38-16-37-69)70(51(3)4)52(5)6)49-78-68(54-19-13-12-14-20-54,55-21-26-58(71-10)27-22-55)56-23-28-59(72-11)29-24-56/h12-14,19-29,50-53,60-65H,15-18,30-36,38-49H2,1-11H3/t53-,60+,61?,62+,63-,64+,65+,66+,67-,81?/m1/s1

Synonyms: 1-O-(4,4'-dimethoxytrityl)-Glycerol-Triethyleneglycol-Cholesterol-2-Cyanoethyl Phosphoramidite; Cholesteryl amidite (plant source); Cholesteryl amidite

TEG Linker2

Description: TEG Linker2 refers to a second-generation triethylene glycol linker. It is utilized in bioconjugation chemistry to attach biomolecules to surfaces or to modify their physicochemical properties, improving their solubility and stability in various biological environments.

CAT: BRP-01108

CAS: 3030325-67-5

MF: C33H45NO8

MF: 583.71

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Density: 1.139±0.06 g/cm3

Boiling Point: 701.6±60.0 °C at 760 mmHg

InChIKey: XNEDRVJRLFZTIK-UHFFFAOYSA-N

CanonicalSMILES: COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)OCC(COCCOCCOCCOCCCN)O

IUPAC Name: 1-[2-[2-[2-(3-aminopropoxy)ethoxy]ethoxy]ethoxy]-3-[bis(4-methoxyphenyl)-phenylmethoxy]propan-2-ol

InChI: InChI=1S/C33H45NO8/c1-36-31-13-9-28(10-14-31)33(27-7-4-3-5-8-27,29-11-15-32(37-2)16-12-29)42-26-30(35)25-41-24-23-40-22-21-39-20-19-38-18-6-17-34/h3-5,7-16,30,35H,6,17-26,34H2,1-2H3

Synonyms: 16-amino-1-O-(4,4'-dimethoxytrityl)-4,7,10,13-tetraoxahexadecan-1,2-diol; 18-amino-1,1-bis(4-methoxyphenyl)-1-phenyl-2,6,9,12,15-pentaoxaoctadecan-4-ol; 2-Propanol, 1-[2-[2-[2-(3-aminopropoxy)ethoxy]ethoxy]ethoxy]-3-[bis(4-methoxyphenyl)phenylmethoxy]-

6-O-DMTr-hexane-bis-(diisopropylamino)-Phosphane

Description: This compound is a phosphoramidite derivative used in oligonucleotide synthesis. It features a hexane-bis-(diisopropylamino) phosphane group protected with a dimethoxytrityl (DMTr) group at the 6-position. It facilitates controlled and efficient coupling of oligonucleotides during solid-phase synthesis, ensuring high yields and purity of the final products.

CAT: BRP-01110

MF: C39H59N2O4P

MF: 650.88

Purity: ≥97% by HPLC

Appearance: Colorless to light yellow oily matter

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Storage: Store at -20 °C

InChIKey: VJKCRNMYXQZNIK-UHFFFAOYSA-N

CanonicalSMILES: CC(N(P(OCCCCCCOC(C1=CC=CC=C1)(C(C=C2)=CC=C2OC)C(C=C3)=CC=C3OC)N(C(C)C)C(C)C)C(C)C)C

IUPAC Name: 1-((6-(bis(4-methoxyphenyl)(phenyl)methoxy)hexyl)oxy)-N,N,N',N'-tetraisopropylphosphanediamine

InChI: InChI=1S/C39H59N2O4P/c1-30(2)40(31(3)4)46(41(32(5)6)33(7)8)45-29-17-12-11-16-28-44-39(34-18-14-13-15-19-34,35-20-24-37(42-9)25-21-35)36-22-26-38(43-10)27-23-36/h13-15,18-27,30-33H,11-12,16-17,28-29H2,1-10H3

Synonyms: 6-O-(4,4'-dimethoxytrityl)-hexane-bis-(diisopropylamino)-Phosphane

5'-O-DMTr-2'-O-(methoxycarbonyl)methyl-G(iBu)-3'-CE-Phosphoramidite

Description: This phosphoramidite derivative introduces a modified guanosine nucleoside where the 2'-hydroxyl group is protected with a methoxycarbonyl methyl group (OMeCOOMe). It is protected at the 5'-position with a dimethoxytrityl (DMTr) group and at the 3'-position with a cyanoethyl (CE) group. This modification can stabilize RNA structures, alter enzymatic properties, or enhance binding affinity in biochemical and therapeutic applications.

CAT: BRP-01111

MF: C47H58N7O11P

MF: 927.99

Purity: ≥98% by UPLC

Appearance: White, off-white to light yellow powder

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InChIKey: IJABPRIFTVFZJB-NCJSJSGWSA-N

IUPAC Name: methyl 2-(((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-2-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl)oxy)acetate

InChI: InChI=1S/C47H58N7O11P/c1-29(2)43(56)51-46-50-42-39(44(57)52-46)49-28-53(42)45-41(61-27-38(55)60-9)40(65-66(63-25-13-24-48)54(30(3)4)31(5)6)37(64-45)26-62-47(32-14-11-10-12-15-32,33-16-20-35(58-7)21-17-33)34-18-22-36(59-8)23-19-34/h10-12,14-23,28-31,37,40-41,45H,13,25-27H2,1-9H3,(H2,50,51,52,56,57)/t37-,40-,41-,45-,66?/m1/s1

Synonyms: N6-benzoyl-5'-O-(4,4'-Dimethoxytrityl)-2'-O-(methoxycarbonyl)methyl-guanosine-3'-[(2-cyanoethyl)-(N,N-diisopropropyl)]-Phosphoramidite

5'-O-DMTr-2'-O-(methoxycarbonyl)methyl-5-Me-C(iBu)-3'-CE-Phosphoramidite

Description: This phosphoramidite introduces a modified 5-methylcytidine nucleoside where the 2'-hydroxyl group is protected with a methoxycarbonyl methyl group (OMeCOOMe). It is protected at the 5'-position with a DMTr group and at the 3'-position with a CE group. This modification is useful for studying RNA stability, protein binding, and enzymatic activity.

CAT: BRP-01112

MF: C47H60N5O11P

MF: 901.99

Purity: ≥98% by UPLC

Appearance: White, off-white to light yellow powder

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InChIKey: GLHSMORVQTYUKD-LKYMEUIMSA-N

IUPAC Name: methyl 2-(((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-2-(4-isobutyramido-5-methyl-2-oxopyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)oxy)acetate

InChI: InChI=1S/C47H60N5O11P/c1-30(2)44(54)49-43-33(7)27-51(46(55)50-43)45-42(59-29-40(53)58-10)41(63-64(61-26-14-25-48)52(31(3)4)32(5)6)39(62-45)28-60-47(34-15-12-11-13-16-34,35-17-21-37(56-8)22-18-35)36-19-23-38(57-9)24-20-36/h11-13,15-24,27,30-32,39,41-42,45H,14,26,28-29H2,1-10H3,(H,49,50,54,55)/t39-,41-,42-,45-,64?/m1/s1

Synonyms: N6-benzoyl-5'-O-(4,4'-Dimethoxytrityl)-2'-O-(methoxycarbonyl)methyl-5-methyl-cytidine-3'-[(2-cyanoethyl)-(N,N-diisopropropyl)]-Phosphoramidite

5'-O-DMTr-2'-O-(methoxycarbonyl)methyl-5-Me-U-3'-CE-Phosphoramidite

Description: This phosphoramidite introduces a modified 5-methyluridine nucleoside where the 2'-hydroxyl group is protected with a methoxycarbonyl methyl group (OMeCOOMe). It is protected at the 5'-position with a DMTr group and at the 3'-position with a CE group. Modifications like this can influence RNA structure and function, impacting gene expression and regulatory mechanisms.

CAT: BRP-01113

CAS: 304442-34-0

MF: C43H53N4O11P

MF: 832.89

Purity: ≥98% by UPLC

Appearance: White, off-white to light yellow powder

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InChIKey: CYKHRNSJKAITPH-FMMLDEGOSA-N

CanonicalSMILES: CC1=CN(C(=O)NC1=O)C2C(C(C(O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OP(N(C(C)C)C(C)C)OCCC#N)OCC(=O)OC

IUPAC Name: methyl 2-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-2-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxyacetate

InChI: InChI=1S/C43H53N4O11P/c1-28(2)47(29(3)4)59(56-24-12-23-44)58-38-36(57-41(39(38)54-27-37(48)53-8)46-25-30(5)40(49)45-42(46)50)26-55-43(31-13-10-9-11-14-31,32-15-19-34(51-6)20-16-32)33-17-21-35(52-7)22-18-33/h9-11,13-22,25,28-29,36,38-39,41H,12,24,26-27H2,1-8H3,(H,45,49,50)/t36-,38-,39-,41-,59?/m1/s1

Synonyms: N6-benzoyl-5'-O-(4,4'-Dimethoxytrityl)-2'-O-(methoxycarbonyl)methyl-5-methyl-uridine-3'-[(2-cyanoethyl)-(N,N-diisopropropyl)]-Phosphoramidite; methyl 2-(((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)oxy)acetate; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxy-2-oxoethyl)-5-methyl-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

5'-O-DMTr-2'-O-(methoxycarbonyl)methyl-A(Bz)-3'-CE-Phosphoramidite

Description: This phosphoramidite introduces a modified adenosine nucleoside where the 2'-hydroxyl group is protected with a methoxycarbonyl methyl group (OMeCOOMe). It is protected at the 5'-position with a DMTr group and at the 3'-position with a CE group. Such modifications are crucial for designing RNA molecules with specific structural or functional properties in research and therapeutic applications.

CAT: BRP-01114

CAS: 329279-48-3

MF: C50H56N7O10P

MF: 946.01

Purity: ≥98% by UPLC

Appearance: White, off-white to light yellow powder

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InChIKey: BHOZQFFADFBWRN-GNUXOQNYSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OCC(=O)OC)N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC

IUPAC Name: methyl 2-[(2R,3R,4R,5R)-2-(6-benzamidopurin-9-yl)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-3-yl]oxyacetate

InChI: InChI=1S/C50H56N7O10P/c1-33(2)57(34(3)4)68(65-28-14-27-51)67-44-41(29-64-50(36-17-12-9-13-18-36,37-19-23-39(60-5)24-20-37)38-21-25-40(61-6)26-22-38)66-49(45(44)63-30-42(58)62-7)56-32-54-43-46(52-31-53-47(43)56)55-48(59)35-15-10-8-11-16-35/h8-13,15-26,31-34,41,44-45,49H,14,28-30H2,1-7H3,(H,52,53,55,59)/t41-,44-,45-,49-,68?/m1/s1

Synonyms: N6-benzoyl-5'-O-(4,4'-Dimethoxytrityl)-2'-O-(methoxycarbonyl)methyl-adenosine-3'-[(2-cyanoethyl)-(N,N-diisopropropyl)]-Phosphoramidite; Methyl 2-(((2R,3R,4R,5R)-2-(6-benzamido-9H-purin-9-yl)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)tetrahydrofuran-3-yl)oxy)acetate; Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxy-2-oxoethyl)-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

5'-O-DMTr-2'-O-Me-8-Me-G(dmf)-3'-CE Phosphoramidite

Description: This phosphoramidite introduces an 8-methylguanosine nucleoside where the 2'-hydroxyl group is protected with a methyl group. It is protected at the 5'-position with a DMTr group and at the 3'-position with a CE group. Modifications like 8-methylguanosine can alter RNA stability, folding, and interactions with proteins or small molecules, impacting biological processes.

CAT: BRP-01115

MF: C45H57N8O8P

MF: 868.97

Purity: ≥97% by UPLC

Appearance: White, off-white to light yellow powder

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InChIKey: IJFUVMLFBVVNDL-GDLAVZMWSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-(((dimethylamino)methylene)amino)-8-methyl-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C45H57N8O8P/c1-29(2)53(30(3)4)62(59-26-14-25-46)61-39-37(60-43(40(39)57-10)52-31(5)48-38-41(52)49-44(50-42(38)54)47-28-51(6)7)27-58-45(32-15-12-11-13-16-32,33-17-21-35(55-8)22-18-33)34-19-23-36(56-9)24-20-34/h11-13,15-24,28-30,37,39-40,43H,14,26-27H2,1-10H3,(H,49,50,54)/t37-,39-,40-,43-,62?/m1/s1

Synonyms: N2-dimethylformamide-8-methyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-guanosine-3'-cyanoethyl Phosphoramidite

5'-O-DMTr-7-deaza-2'-O-Me-G(iBu)-3'-CE-Phosphoramidite

Description: 5'-O-DMTr-7-deaza-2'-O-Me-G(iBu)-3'-CE-Phosphoramidite is a phosphoramidite utilized in oligonucleotide synthesis. It incorporates a modified form of guanosine into nucleic acid sequences, featuring a 7-deaza substitution, a methyl group at the 2'-position of the ribose sugar, and an isobutyryl protecting group on the guanosine base. Additionally, it contains a cyanoethyl protecting group at the 3'-position to aid in solid-phase synthesis. This compound enables controlled synthesis of modified oligonucleotides for various molecular biology applications.

CAT: BRP-01116

MF: C46H57N6O9P

MF: 868.97

Purity: ≥98% by HPLC

Appearance: White to off-white powder

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Storage: Store at -20 °C

InChIKey: BKKPILOQLJDDRS-BFXDPCJQSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C46H57N6O9P/c1-29(2)42(53)49-45-48-41-37(43(54)50-45)24-26-51(41)44-40(57-9)39(61-62(59-27-13-25-47)52(30(3)4)31(5)6)38(60-44)28-58-46(32-14-11-10-12-15-32,33-16-20-35(55-7)21-17-33)34-18-22-36(56-8)23-19-34/h10-12,14-24,26,29-31,38-40,44H,13,27-28H2,1-9H3,(H2,48,49,50,53,54)/t38-,39-,40-,44-,62?/m1/s1

Synonyms: N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-7-deaza-2'-O-methyl-guanosine-3'-cyanoethyl Phosphoramidite; 7-deaza-2'-O-Methyl Guanosine CED phosphoramidite; 7-deaza 2'-O-Methyl G(iBu) 3'-CE phosphoramidite