Phosphoramidites - RNA / BOC Sciences

2'-OTBS Pyridinone amidite

Description: 2'-OTBS Pyridinone amidite is a reagent used in oligonucleotide synthesis, featuring a tert-butyldimethylsilyl (TBS) protecting group at the 2' position of ribose and incorporating a pyridinone moiety. This amidite enables the controlled synthesis of oligonucleotides with pyridinone modifications, offering unique properties or functionalities for applications in biotechnology and therapeutics.

CAT: BRP-00959

CAS: 179915-57-2

MF: C46H62N3O8PSi

MF: 844.08

Purity: >95%

Appearance: Off-white solid

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InChIKey: FMVRDFSSWDAZFJ-VDXGOTTOSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=CC=CC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-5-(2-oxopyridin-1-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C46H62N3O8PSi/c1-33(2)49(34(3)4)58(54-31-17-29-47)56-42-40(55-44(48-30-16-15-20-41(48)50)43(42)57-59(10,11)45(5,6)7)32-53-46(35-18-13-12-14-19-35,36-21-25-38(51-8)26-22-36)37-23-27-39(52-9)28-24-37/h12-16,18-28,30,33-34,40,42-44H,17,31-32H2,1-11H3/t40-,42-,43-,44-,58?/m1/s1

Synonyms: Pyridin-2-one-CE Phosphoramidite; 5'-Dimethoxytrityl-pyridin-2-one-riboside, 2'-O-TBDMS-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; Pyridin-2-one riboside CEP; 2(1H)-Pyridinone, 1-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-O-[(1,1-dimethylethyl)dimethylsilyl]-β-D-ribofuranosyl]-; 1-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-O-[(1,1-dimethylethyl)dimethylsilyl]-β-D-ribofuranosyl]-2(1H)-pyridinone; (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2-oxopyridin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; Pyridine-2-One CED phosphoramidite

Tocopherol amidite

Description: Tocopherol amidite is a reagent utilized in oligonucleotide synthesis. It contains a tocopherol moiety, which is a form of vitamin E, attached to an amidite group suitable for solid-phase synthesis. This reagent allows for the conjugation of tocopherol to oligonucleotides during synthesis. Tocopherol modifications can provide various properties such as increased stability, cellular uptake, or antioxidant activity to the resulting oligonucleotides, making them potentially useful for applications in drug delivery or other biomedical fields.

CAT: BRP-00960

CAS: 142386-74-1

MF: C38H67N2O3P

MF: 630.94

Purity: >95%

Appearance: Light-yellow oily matter

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InChIKey: USUSEQXJHLFSON-UHFFFAOYSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC1=C(C(=C(C2=C1OC(CC2)(C)CCCC(C)CCCC(C)CCCC(C)C)C)OP(N(C(C)C)C(C)C)OCCC#N)C

IUPAC Name: 3-[[di(propan-2-yl)amino]-[[2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydrochromen-6-yl]oxy]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C38H67N2O3P/c1-27(2)17-13-18-30(7)19-14-20-31(8)21-15-23-38(12)24-22-35-34(11)36(32(9)33(10)37(35)42-38)43-44(41-26-16-25-39)40(28(3)4)29(5)6/h27-31H,13-24,26H2,1-12H3

Synonyms: Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl ester; 2-Cyanoethyl 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl N,N-bis(1-methylethyl)phosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, 2-cyanoethyl 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl ester; 2-cyanoethyl (2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)chroman-6-yl) diisopropylphosphoramidite

C8 amidite

Description: C8 amidite is a linker used in oligonucleotide synthesis. This linker provides a connection between the oligonucleotide and other molecules or surfaces during synthesis or conjugation processes. The ''C8'' designation indicates that it consists of a linker with an 8-carbon chain length. This linker facilitates the attachment of oligonucleotides to various molecules or surfaces, enabling specific applications such as biomolecule conjugation, solid-phase synthesis, or surface immobilization in bioassays.

CAT: BRP-00961

CAS: 194015-05-9

MF: C17H35N2O2P

MF: 330.45

Purity: >98%

Appearance: Light-yellow oily matter

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InChIKey: SYIZTDJMSOSVGQ-UHFFFAOYSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CCCCCCCCOP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: 3-[[di(propan-2-yl)amino]-octoxyphosphanyl]oxypropanenitrile

InChI: InChI=1S/C17H35N2O2P/c1-6-7-8-9-10-11-14-20-22(21-15-12-13-18)19(16(2)3)17(4)5/h16-17H,6-12,14-15H2,1-5H3

Synonyms: 2-Cyanoethyl octyl diisopropylphosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, 2-cyanoethyl octyl ester; O-β-Cyanoethyl-O-octyl-N,N-diisopropyl phosphoramidite

C11 amidite

Description: C11 amidite is a linker used in oligonucleotide synthesis, consisting of an 11-carbon chain length. This linker facilitates the connection between the oligonucleotide and other molecules or surfaces during synthesis or conjugation processes. It provides flexibility and space between the oligonucleotide and the attached moiety, enabling various applications such as biomolecule conjugation, solid-phase synthesis, or surface immobilization in bioassays.

CAT: BRP-00962

CAS: 125676-85-9

MF: C20H41N2O2P

MF: 372.53

Purity: >98%

Appearance: Light-yellow oily matter

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InChIKey: IJPKCIKPYVOSEV-UHFFFAOYSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: N#CCCOP(OCCCCCCCCCCC)N(C(C)C)C(C)C

IUPAC Name: 2-cyanoethyl undecyl diisopropylphosphoramidite

InChI: InChI=1S/C20H41N2O2P/c1-6-7-8-9-10-11-12-13-14-17-23-25(24-18-15-16-21)22(19(2)3)20(4)5/h19-20H,6-15,17-18H2,1-5H3

Synonyms: 2-Cyanoethyl undecyl diisopropylphosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl undecyl ester; 2-Cyanoethyl undecyl N,N-bis(1-methylethyl)phosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, 2-cyanoethyl undecyl ester

C14 amidite

Description: C14 amidite is a linker utilized in oligonucleotide synthesis, featuring a 14-carbon chain length. This linker serves to connect the oligonucleotide to other molecules or surfaces during synthesis or conjugation processes. The ''C14'' designation indicates the length of the carbon chain in the linker. It provides flexibility and space between the oligonucleotide and the attached moiety, facilitating specific applications such as biomolecule conjugation, solid-phase synthesis, or surface immobilization in various bioassays.

CAT: BRP-00963

CAS: 198987-41-6

MF: C23H47N2O2P

MF: 414.62

Purity: >98%

Appearance: Light-yellow oily matter

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InChIKey: BGMXNCIZEALUBC-UHFFFAOYSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CCCCCCCCCCCCCCOP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: 3-[[di(propan-2-yl)amino]-tetradecoxyphosphanyl]oxypropanenitrile

InChI: InChI=1S/C23H47N2O2P/c1-6-7-8-9-10-11-12-13-14-15-16-17-20-26-28(27-21-18-19-24)25(22(2)3)23(4)5/h22-23H,6-18,20-21H2,1-5H3

Synonyms: 2-Cyanoethyl tetradecyl diisopropylphosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl tetradecyl ester; 2-Cyanoethyl tetradecyl N,N-bis(1-methylethyl)phosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, 2-cyanoethyl tetradecyl ester

11-Br-C11 amidite

Description: 11-Br-C11 amidite is a reagent used in oligonucleotide synthesis, featuring an 11-carbon chain length with a bromine (Br) atom. This linker allows for the attachment of oligonucleotides to other molecules or surfaces during synthesis or conjugation processes. The bromine atom provides a reactive site for further functionalization or coupling reactions. It provides flexibility and space between the oligonucleotide and the attached moiety, enabling specific applications such as biomolecule conjugation, solid-phase synthesis, or surface immobilization in various bioassays.

CAT: BRP-00964

CAS: 804567-08-6

MF: C20H40BrN2O2P

MF: 451.43

Purity: >98%

Appearance: Light-yellow oily matter

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InChIKey: MZMSOHBMQFZJNM-UHFFFAOYSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: N#CCCOP(OCCCCCCCCCCCBr)N(C(C)C)C(C)C

IUPAC Name: 11-bromoundecyl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C20H40BrN2O2P/c1-19(2)23(20(3)4)26(25-18-14-16-22)24-17-13-11-9-7-5-6-8-10-12-15-21/h19-20H,5-15,17-18H2,1-4H3

Synonyms: Phosphoramidous acid, bis(1-methylethyl)-, 11-bromoundecyl 2-cyanoethyl ester

2'-O-NMA PseudoUridine amidite

Description: 2'-O-NMA PseudoUridine amidite is a reagent used in oligonucleotide synthesis, featuring a modification at the 2' position of ribose with N-methylaminomethylene (NMA) and incorporating a pseudo-uridine moiety. This reagent enables the synthesis of oligonucleotides containing pseudo-uridine modifications, which can confer specific properties or functionalities to the resulting oligonucleotides. PseudoUridine modifications are valuable for applications in biotechnology and therapeutics due to their potential to enhance stability, specificity, or other desired characteristics.

CAT: BRP-00965

MF: C42H52N5O10P

MF: 817.88

Purity: >95%

Appearance: Off-white solid

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InChIKey: NHSKCVXWHUBLRO-AZUJSHLHSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4S,5S)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-4-(2-(methylamino)-2-oxoethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C42H52N5O10P/c1-27(2)47(28(3)4)58(55-23-11-22-43)57-38-35(56-37(39(38)53-26-36(48)44-5)34-24-45-41(50)46-40(34)49)25-54-42(29-12-9-8-10-13-29,30-14-18-32(51-6)19-15-30)31-16-20-33(52-7)21-17-31/h8-10,12-21,24,27-28,35,37-39H,11,23,25-26H2,1-7H3,(H,44,48)(H2,45,46,49,50)/t35-,37+,38-,39+,58?/m1/s1

2'-O-NMA N1-Methyl PseudoUridine amidite

Description: 2'-O-NMA N1-Methyl PseudoUridine amidite is a reagent employed in oligonucleotide synthesis. It involves a modification at the 2' position of ribose with N-methylaminomethylene (NMA) and incorporates N1-Methyl PseudoUridine, a modified nucleoside resembling uridine with a methyl group attached to the nitrogen at position 1. This reagent enables the synthesis of oligonucleotides with N1-Methyl PseudoUridine modifications, offering specific properties or functionalities to the resulting oligonucleotides. These modifications can be advantageous for various biotechnological and therapeutic applications, providing enhanced stability or other desired characteristics.

CAT: BRP-00966

MF: C43H54N5O10P

MF: 831.90

Purity: >95%

Appearance: Off-white solid

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InChIKey: PRKXXSDXURDTSF-ZIVCPKBRSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4S,5S)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-4-(2-(methylamino)-2-oxoethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C43H54N5O10P/c1-28(2)48(29(3)4)59(56-24-12-23-44)58-39-36(57-38(40(39)54-27-37(49)45-5)35-25-47(6)42(51)46-41(35)50)26-55-43(30-13-10-9-11-14-30,31-15-19-33(52-7)20-16-31)32-17-21-34(53-8)22-18-32/h9-11,13-22,25,28-29,36,38-40H,12,24,26-27H2,1-8H3,(H,45,49)(H,46,50,51)/t36-,38+,39-,40+,59?/m1/s1

2'-OEt-S-S-tBu C(Bz) amidite

Description: 2'-OEt-S-S-tBu C(Bz) amidite is a reagent used in oligonucleotide synthesis, containing a disulfide linkage with tert-butyl (tBu) termination and cytosine protected with benzoyl (Bz) group at the 2' position of ribose. This modification allows for the introduction of reversible crosslinking or enhanced stability properties to the resulting oligonucleotides.

CAT: BRP-00967

CAS: 176747-35-6

MF: C52H64N5O9PS2

MF: 998.22

Purity: >95%

Appearance: Off-white solid

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InChIKey: GGJPSSSMERVJTA-YOVDOAOFSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=CC(=NC2=O)NC(=O)C=3C=CC=CC3)C1OCCSSC(C)(C)C)COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-(tert-butyldisulfaneyl)ethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C52H64N5O9PS2/c1-36(2)57(37(3)4)67(64-32-16-30-53)66-46-44(35-63-52(39-19-14-11-15-20-39,40-21-25-42(60-8)26-22-40)41-23-27-43(61-9)28-24-41)65-49(47(46)62-33-34-68-69-51(5,6)7)56-31-29-45(55-50(56)59)54-48(58)38-17-12-10-13-18-38/h10-15,17-29,31,36-37,44,46-47,49H,16,32-35H2,1-9H3,(H,54,55,58,59)/t44-,46-,47-,49-,67?/m1/s1

Synonyms: Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[2-[(1,1-dimethylethyl)dithio]ethyl]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

Thio(Bz) C6 amidite

Description: Thio(Bz) C6 amidite is a reagent used in oligonucleotide synthesis, featuring a thiol modification with a benzoyl (Bz) protecting group and a 6-carbon linker. This reagent allows for the introduction of a thiol-modified linker with a 6-carbon chain length into oligonucleotide sequences during synthesis. Thiol modifications can be employed for various applications such as covalent conjugation, labeling, or surface immobilization in bioassays.

CAT: BRP-00968

CAS: 176640-52-1

MF: C22H35N2O3PS

MF: 438.57

Purity: >95%

Appearance: Light-yellow oily matter

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InChIKey: UDUVXNZCIKTQTP-UHFFFAOYSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: N#CCCOP(OCCCCCCSC(=O)C=1C=CC=CC1)N(C(C)C)C(C)C

IUPAC Name: S-(6-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)hexyl) benzothioate

InChI: InChI=1S/C22H35N2O3PS/c1-19(2)24(20(3)4)28(27-17-12-15-23)26-16-10-5-6-11-18-29-22(25)21-13-8-7-9-14-21/h7-9,13-14,19-20H,5-6,10-12,16-18H2,1-4H3

Synonyms: Benzenecarbothioic acid, S-[6-[[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]oxy]hexyl] ester; S-[6-[[[Bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]oxy]hexyl] benzenecarbothioate

Thio(Ac) C6 amidite

Description: Thio(Ac) C6 amidite is a reagent used in oligonucleotide synthesis, featuring a thiol modification with an acetyl (Ac) protecting group and a 6-carbon linker. This reagent enables the introduction of a thiol-modified linker with a 6-carbon chain length into oligonucleotide sequences during synthesis. Thiol modifications can be utilized for various applications such as covalent conjugation, labeling, or surface immobilization in bioassays.

CAT: BRP-00969

CAS: 176640-51-0

MF: C17H33N2O3PS

MF: 376.50

Purity: >95%

Appearance: Light-yellow oily matter

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InChIKey: YYZTVJUOQPJPLL-UHFFFAOYSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: N#CCCOP(OCCCCCCSC(=O)C)N(C(C)C)C(C)C

IUPAC Name: S-(6-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)hexyl) ethanethioate

InChI: InChI=1S/C17H33N2O3PS/c1-15(2)19(16(3)4)23(22-13-10-11-18)21-12-8-6-7-9-14-24-17(5)20/h15-16H,6-10,12-14H2,1-5H3

Synonyms: Ethanethioic acid, S-[6-[[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]oxy]hexyl] ester; S-[6-[[[Bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]oxy]hexyl] ethanethioate

Thio(Ac)-PEG3 amidite

Description: Thio(Ac)-PEG3 amidite is a reagent used in oligonucleotide synthesis, featuring a thiol modification with an acetyl (Ac) protecting group and a polyethylene glycol (PEG) linker of three ethylene glycol units. This reagent allows for the introduction of a thiol-modified linker with a PEG3 spacer into oligonucleotide sequences during synthesis. Thiol modifications with PEG linkers are often employed for various applications such as covalent conjugation, labeling, or improving solubility and flexibility of oligonucleotides.

CAT: BRP-00970

CAS: 153870-21-4

MF: C17H33N2O5PS

MF: 408.50

Purity: >95%

Appearance: Light-yellow oily matter

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InChIKey: FMIVUFGXNQLSTH-UHFFFAOYSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OCCOCCOCCSC(=O)C

IUPAC Name: S-[2-[2-[2-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyethoxy]ethoxy]ethyl] ethanethioate

InChI: InChI=1S/C17H33N2O5PS/c1-15(2)19(16(3)4)25(23-8-6-7-18)24-12-11-21-9-10-22-13-14-26-17(5)20/h15-16H,6,8-14H2,1-5H3

Synonyms: Ethanethioic acid, S-[10-(2-cyanoethoxy)-12-methyl-11-(1-methylethyl)-3,6,9-trioxa-11-aza-10-phosphatridec-1-yl] ester; Ethanethioic acid, S-[10-[bis(1-methylethyl)amino]-13-cyano-3,6,9,11-tetraoxa-10-phosphatridec-1-yl] ester; S-[10-(2-Cyanoethoxy)-12-methyl-11-(1-methylethyl)-3,6,9-trioxa-11-aza-10-phosphatridec-1-yl] ethanethioate; S-(2-(2-(2-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)ethoxy)ethoxy)ethyl) ethanethioate

UNA 2'-OBz C(Bz) amidite

Description: UNA 2'-OBz C(Bz) amidite is a reagent used in oligonucleotide synthesis, containing an Unlocked Nucleic Acid (UNA) backbone modification. In this designation, 2'-OBz indicates a benzoyl (Bz) protecting group at the 2' position of ribose, and C(Bz) indicates cytosine (C) protected with a benzoyl group. This reagent is utilized for synthesizing oligonucleotides with UNA backbone modifications, which increase the flexibility of the oligonucleotide backbone. UNA modifications can confer specific properties to oligonucleotides, such as altering hybridization behavior or enhancing nuclease resistance, suitable for various biotechnological applications.

CAT: BRP-00971

MF: C53H58N5O10P

MF: 956.05

Purity: >95%

Appearance: Off-white solid

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InChIKey: MINLZVSGJNTMMR-OBHWIOKQSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R)-2-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-(((2R)-1-(bis(4-methoxyphenyl)(phenyl)methoxy)-3-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)propan-2-yl)oxy)ethyl benzoate

InChI: InChI=1S/C53H58N5O10P/c1-38(2)58(39(3)4)69(66-34-16-32-54)67-36-47(35-65-53(42-21-14-9-15-22-42,43-23-27-45(62-5)28-24-43)44-25-29-46(63-6)30-26-44)68-49(37-64-51(60)41-19-12-8-13-20-41)57-33-31-48(56-52(57)61)55-50(59)40-17-10-7-11-18-40/h7-15,17-31,33,38-39,47,49H,16,34-37H2,1-6H3,(H,55,56,59,61)/t47-,49-,69?/m1/s1

2'-MOE PseudoUridine amidite

Description: 2'-MOE PseudoUridine amidite is a reagent used in oligonucleotide synthesis. This reagent contains a modification at the 2' position of ribose with 2'-O-methoxyethyl (MOE) and incorporates PseudoUridine, a modified nucleoside resembling uridine. This allows for the synthesis of oligonucleotides containing PseudoUridine modifications, which can impart specific properties or functionalities to the resulting oligonucleotides, useful for various biotechnological applications.

CAT: BRP-00972

CAS: 1417162-48-1

MF: C42H53N4O10P

MF: 804.88

Purity: >95%

Appearance: Off-white solid

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InChIKey: QGENAASPFJKDDU-APSGJOCZSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: N#CCCOP(OC1C(OC(C2=CNC(=O)NC2=O)C1OCCOC)COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4S,5S)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C42H53N4O10P/c1-28(2)46(29(3)4)57(54-23-11-22-43)56-38-36(55-37(39(38)52-25-24-49-5)35-26-44-41(48)45-40(35)47)27-53-42(30-12-9-8-10-13-30,31-14-18-33(50-6)19-15-31)32-16-20-34(51-7)21-17-32/h8-10,12-21,26,28-29,36-39H,11,23-25,27H2,1-7H3,(H2,44,45,47,48)/t36-,37+,38-,39+,57?/m1/s1

Synonyms: 2,4(1H,3H)-Pyrimidinedione, 5-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-O-(2-methoxyethyl)-β-D-ribofuranosyl]-; 5-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-O-(2-methoxyethyl)-β-D-ribofuranosyl]-2,4(1H,3H)-pyrimidinedione

2'-MOE N1-Methyl PseudoUridine amidite

Description: 2'-MOE N1-Methyl PseudoUridine amidite is a reagent used in oligonucleotide synthesis. This reagent contains a modification at the 2' position of ribose with 2'-O-methoxyethyl (MOE) and incorporates N1-Methyl PseudoUridine, a modified nucleoside resembling uridine with a methyl group attached to the nitrogen at position 1. It enables the synthesis of oligonucleotides containing N1-Methyl PseudoUridine modifications, offering specific properties or functionalities to the resulting oligonucleotides, suitable for various biotechnological applications.

CAT: BRP-00973

MF: C43H55N4O10P

MF: 818.91

Purity: >95%

Appearance: Off-white solid

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InChIKey: FWVPZDATJBTJIH-SAAFSQBVSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4S,5S)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)-5-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C43H55N4O10P/c1-29(2)47(30(3)4)58(55-24-12-23-44)57-39-37(56-38(40(39)53-26-25-50-6)36-27-46(5)42(49)45-41(36)48)28-54-43(31-13-10-9-11-14-31,32-15-19-34(51-7)20-16-32)33-17-21-35(52-8)22-18-33/h9-11,13-22,27,29-30,37-40H,12,24-26,28H2,1-8H3,(H,45,48,49)/t37-,38+,39-,40+,58?/m1/s1

2'-OMe 5-Ethynyl-U amidite

Description: 2'-OMe 5-Ethynyl-U amidite is a reagent used in oligonucleotide synthesis. This reagent contains a modification at the 2' position of ribose with 2'-O-methyl (OMe) and incorporates 5-Ethynyl-Uridine (5-Ethynyl-U), a modified uridine nucleoside with an ethynyl group attached at the 5-position of the uracil base. It allows for the synthesis of oligonucleotides containing 5-Ethynyl-Uridine modifications, which can be useful for various applications such as click chemistry reactions for further functionalization or conjugation.

CAT: BRP-00974

CAS: 2201814-30-2

MF: C42H49N4O9P

MF: 784.85

Purity: >95%

Appearance: Off-white solid

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InChIKey: FTWDORGUPXUAIL-WDABSCDASA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=C(C#C)C(=O)NC2=O)C1OC)COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(5-ethynyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C42H49N4O9P/c1-9-30-26-45(41(48)44-39(30)47)40-38(51-8)37(55-56(53-25-13-24-43)46(28(2)3)29(4)5)36(54-40)27-52-42(31-14-11-10-12-15-31,32-16-20-34(49-6)21-17-32)33-18-22-35(50-7)23-19-33/h1,10-12,14-23,26,28-29,36-38,40H,13,25,27H2,2-8H3,(H,44,47,48)/t36-,37-,38-,40-,56?/m1/s1

2'-MOE 2-Thio-U amidite

Description: 2'-MOE 2-Thio-U amidite is a reagent used in oligonucleotide synthesis. This reagent contains a modification at the 2' position of ribose with 2'-O-methoxyethyl (MOE) and incorporates 2-Thio-Uridine (2-Thio-U), a modified uridine nucleoside with a sulfur atom (S) at the 2-position of the uracil base. It facilitates the synthesis of oligonucleotides containing 2-Thio-Uridine modifications, which can impart specific properties or functionalities to the resulting oligonucleotides, useful for various biotechnological applications.

CAT: BRP-00975

CAS: 647839-25-6

MF: C42H53N4O9PS

MF: 820.95

Purity: >95%

Appearance: Off-white solid

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InChIKey: PRCKCMMLZPXTNK-CYSIDSPMSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OCCOC)N2C=CC(=O)NC2=S)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-(2-methoxyethoxy)-5-(4-oxo-2-sulfanylidenepyrimidin-1-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C42H53N4O9PS/c1-29(2)46(30(3)4)56(53-25-11-23-43)55-38-36(54-40(39(38)51-27-26-48-5)45-24-22-37(47)44-41(45)57)28-52-42(31-12-9-8-10-13-31,32-14-18-34(49-6)19-15-32)33-16-20-35(50-7)21-17-33/h8-10,12-22,24,29-30,36,38-40H,11,25-28H2,1-7H3,(H,44,47,57)/t36-,38-,39-,40-,56?/m1/s1

Synonyms: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-2-thio-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)-5-(4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

2'-OMe 2-Thio-U amidite

Description: 2'-OMe 2-Thio-U amidite is a reagent employed in oligonucleotide synthesis. This reagent features a modification at the 2' position of ribose with 2'-O-methyl (OMe) and incorporates 2-Thio-Uridine (2-Thio-U), which is a modified uridine nucleoside with a sulfur atom (S) at the 2-position of the uracil base. It enables the synthesis of oligonucleotides containing 2-Thio-Uridine modifications. These modifications can confer specific properties or functionalities to the resulting oligonucleotides, suitable for various applications in biotechnology and molecular biology.

CAT: BRP-00976

CAS: 302918-84-9

MF: C40H49N4O8PS

MF: 776.89

Purity: >95%

Appearance: Off-white solid

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InChIKey: DWDMFECIJNQDJC-GFIGKZKCSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OC)N2C=CC(=O)NC2=S)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-methoxy-5-(4-oxo-2-sulfanylidenepyrimidin-1-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C40H49N4O8PS/c1-27(2)44(28(3)4)53(50-25-11-23-41)52-36-34(51-38(37(36)48-7)43-24-22-35(45)42-39(43)54)26-49-40(29-12-9-8-10-13-29,30-14-18-32(46-5)19-15-30)31-16-20-33(47-6)21-17-31/h8-10,12-22,24,27-28,34,36-38H,11,25-26H2,1-7H3,(H,42,45,54)/t34-,36-,37-,38-,53?/m1/s1

Synonyms: 2'-O-Me-2-thio-U-3'-phosphoramidite; 2'-O-Me-s2U-3'-[2-cyanoethyl-N,N-diisopropylphosphoramidite]; 5'-O-DMTr-2'-O-methyl-2-thiouridine-3'-CED-phosphoramidite; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-2-thio-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-2-thio-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; 5'-O-DMTr-2'-O-Me-2-thiouridine-3'-CE-Phosphoramidite; 5'-O-(4,4'-dimethoxytrityl)-2'-methoxyl-2-thiouridine-3'-cyanoethyl Phosphoramidite

2'-OTBS 5-CMOM-U amidite

Description: 2'-OTBS 5-CMOM-U amidite is a reagent used in oligonucleotide synthesis. This reagent contains a modification at the 2' position of ribose with 2'-O-tert-butyldimethylsilyl (OTBS) and incorporates 5-CMOM-Uridine (5-CMOM-U). It allows for the synthesis of oligonucleotides containing 5-CMOM-Uridine modifications, which can be useful for various applications in oligonucleotide chemistry and nucleic acid research.

CAT: BRP-00977

CAS: 321991-69-9

MF: C48H65N4O11PSi

MF: 933.13

Purity: >95%

Appearance: Off-white solid

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InChIKey: LBQONPUJFDFCPG-ZHVPLOFZSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=C(C(=O)NC2=O)CC(=O)OC)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: methyl 2-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]-2,4-dioxopyrimidin-5-yl]acetate

InChI: InChI=1S/C48H65N4O11PSi/c1-32(2)52(33(3)4)64(60-28-16-27-49)62-42-40(61-45(43(42)63-65(11,12)47(5,6)7)51-30-34(29-41(53)58-10)44(54)50-46(51)55)31-59-48(35-17-14-13-15-18-35,36-19-23-38(56-8)24-20-36)37-21-25-39(57-9)26-22-37/h13-15,17-26,30,32-33,40,42-43,45H,16,28-29,31H2,1-12H3,(H,50,54,55)/t40-,42-,43-,45-,64?/m1/s1

Synonyms: methyl 2-(1-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)tetrahydrofuran-2-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)acetate; 5-Pyrimidineacetic acid, 1-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-O-[(1,1-dimethylethyl)dimethylsilyl]-β-D-ribofuranosyl]-1,2,3,4-tetrahydro-2,4-dioxo-, methyl ester; Methyl 1-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-O-[(1,1-dimethylethyl)dimethylsilyl]-β-D-ribofuranosyl]-1,2,3,4-tetrahydro-2,4-dioxo-5-pyrimidineacetate

2'-OTBS 5,6-dihydro-U amidite

Description: 2'-OTBS 5,6-dihydro-U amidite is a compound used in oligonucleotide synthesis. It features protective groups (DMTr and TBDMS) for the 5'- and 2'-hydroxyl groups, respectively, and a 5,6-dihydrouridine modification. Additionally, it contains a 3'-cyanoethyl (CE) phosphoramidite group for incorporation into oligonucleotide chains during synthesis.

CAT: BRP-00978

CAS: 126684-14-8

MF: C45H63N4O9PSi

MF: 863.08

Purity: >98%

Appearance: Off-white solid

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InChIKey: DJGPHGMBOQJJIE-ZMHKPELYSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2CCC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-5-(2,4-dioxo-1,3-diazinan-1-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C45H63N4O9PSi/c1-31(2)49(32(3)4)59(55-29-15-27-46)57-40-38(56-42(48-28-26-39(50)47-43(48)51)41(40)58-60(10,11)44(5,6)7)30-54-45(33-16-13-12-14-17-33,34-18-22-36(52-8)23-19-34)35-20-24-37(53-9)25-21-35/h12-14,16-25,31-32,38,40-42H,15,26,28-30H2,1-11H3,(H,47,50,51)/t38-,40-,41-,42-,59?/m1/s1

Synonyms: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-5,6-dihydro-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-5,6-dihydro-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; 5'-O-DMTr-2'-O-TBDMS-5,6-dihydrouridine-3'-CE-Phosphoramidite; 5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyl-dimethylsilyl)-5,6-dihydrouridine-3'-cyanoethyl Phosphoramidite; 5,6-dihydrouridine-2'-TBDMS-5'-DMT 3'-CED phosphoramidite