Phosphoramidites - RNA / BOC Sciences

[5'-O-DMTr-2'-OMe-A(Bz)](P-thio-pCyEt) [2'-O-Me-A(Bz)-3'-CE-Phosphoramidite]

Description: [5'-O-DMTr-2'-OMe-A(Bz)](P-thio-pCyEt) [2'-O-Me-A(Bz)-3'-CE-Phosphoramidite] is a modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of a 5'-O-DMTr-2'-OMe-adenosine with a benzoyl (Bz) protecting group, coupled with a 2'-O-Me-adenosine also featuring a benzoyl (Bz) protecting group. These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making it valuable for biochemical research and therapeutic applications.

CAT: BRP-01157

MF: C69H75N13O14P2S

MF: 1404.44

Purity: ≥97% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: XCGJIPXEZUXVNV-YKUGJANUSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C(=NC=NC32)NC(=O)C=4C=CC=CC4)C1OC)COP(=S)(OCCC#N)OC5C(OC(N6C=NC=7C(=NC=NC76)NC(=O)C=8C=CC=CC8)C5OC)COC(C=9C=CC=CC9)(C%10=CC=C(OC)C=C%10)C%11=CC=C(OC)C=C%11)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((((((2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphorothioyl)oxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C69H75N13O14P2S/c1-44(2)82(45(3)4)97(90-36-18-34-70)95-57-54(94-67(59(57)87-7)80-42-76-55-61(72-40-74-63(55)80)78-65(83)46-20-12-9-13-21-46)39-92-98(99,91-37-19-35-71)96-58-53(93-68(60(58)88-8)81-43-77-56-62(73-41-75-64(56)81)79-66(84)47-22-14-10-15-23-47)38-89-69(48-24-16-11-17-25-48,49-26-30-51(85-5)31-27-49)50-28-32-52(86-6)33-29-50/h9-17,20-33,40-45,53-54,57-60,67-68H,18-19,36-39H2,1-8H3,(H,72,74,78,83)(H,73,75,79,84)/t53-,54-,57-,58-,59-,60-,67-,68-,97?,98?/m1/s1

Synonyms: [5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-A(benzoyl)](P-thio-pCyEt) [2'-O-Me-A(benzoyl)-3'-cyanoethyl-Phosphoramidite]

[5'-O-DMTr-2'-OMe-A(Bz)](pCyEt) [2'-F-dA(Bz)-3'-CE-Phosphoramidite]

Description: [5'-O-DMTr-2'-OMe-A(Bz)](pCyEt) [2'-F-dA(Bz)-3'-CE-Phosphoramidite] is a modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of a 5'-O-DMTr-2'-OMe-adenosine with a benzoyl (Bz) protecting group, coupled with a 2'-fluoro-deoxyadenosine (2'-F-dA) also featuring a benzoyl (Bz) protecting group. These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making it valuable for biochemical research and therapeutic applications.

CAT: BRP-01158

MF: C68H72FN13O14P2

MF: 1376.35

Purity: ≥95% by HPLC

Appearance: White to off-white powder

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InChIKey: XJSBJPLHTAATIR-YKZUEJCGSA-N

IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((((((2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C68H72FN13O14P2/c1-43(2)82(44(3)4)97(90-35-17-33-70)95-57-53(93-66(54(57)69)80-41-76-55-60(72-39-74-62(55)80)78-64(83)45-19-11-8-12-20-45)38-92-98(85,91-36-18-34-71)96-58-52(94-67(59(58)88-7)81-42-77-56-61(73-40-75-63(56)81)79-65(84)46-21-13-9-14-22-46)37-89-68(47-23-15-10-16-24-47,48-25-29-50(86-5)30-26-48)49-27-31-51(87-6)32-28-49/h8-16,19-32,39-44,52-54,57-59,66-67H,17-18,35-38H2,1-7H3,(H,72,74,78,83)(H,73,75,79,84)/t52-,53-,54-,57-,58-,59-,66-,67-,97?,98?/m1/s1

Synonyms: [5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-A(benzoyl)](pCyEt)[2'-Fluoro-dA(benzoyl)-3'-cyanoethyl-Phosphoramidite]

[5'-O-DMTr-2'-OMe-G(iBu)](pCyEt)[2'-F-dC(Ac)-3'-CE-Phosphoramidite]

Description: [5'-O-DMTr-2'-OMe-G(iBu)](pCyEt)[2'-F-dC(Ac)-3'-CE-Phosphoramidite] is a specialized building block used in the chemical synthesis of modified oligonucleotides. The modifications to the guanine and cytidine bases, including methoxy, fluoro, and protective groups, improve the properties of nucleic acids for research and therapeutic applications. This compound is significant in biochemical research and therapeutic development, contributing to advancements in genetic and molecular medicine.

CAT: BRP-01159

MF: C59H72FN11O16P2

MF: 1272.21

Purity: ≥97% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: JWJXHOVUDQYNQH-FVZAZZLTSA-N

IUPAC Name: (2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C59H72FN11O16P2/c1-35(2)53(73)67-57-66-52-48(54(74)68-57)63-34-70(52)56-51(79-10)50(44(85-56)32-80-59(39-16-12-11-13-17-39,40-18-22-42(77-8)23-19-40)41-20-24-43(78-9)25-21-41)87-89(76,82-31-15-28-62)83-33-45-49(86-88(81-30-14-27-61)71(36(3)4)37(5)6)47(60)55(84-45)69-29-26-46(64-38(7)72)65-58(69)75/h11-13,16-26,29,34-37,44-45,47,49-51,55-56H,14-15,30-33H2,1-10H3,(H,64,65,72,75)(H2,66,67,68,73,74)/t44-,45-,47-,49-,50-,51-,55-,56-,88?,89?/m1/s1

Synonyms: [5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-G(isobutyryl)](pCyEt)[2'-Fluoro-dC(acetyl)-3'-cyanoethyl-Phosphoramidite]

[5'-O-DMTr-2'-F-dC(Ac)](pCyEt)[2'-OMe-A(Bz)-3'-CE-Phosphoramidite]

Description: [5'-O-DMTr-2'-F-dC(Ac)](pCyEt)[2'-OMe-A(Bz)-3'-CE-Phosphoramidite] is a modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of a 5'-O-DMTr-2'-fluoro-deoxycytidine (2'-F-dC) with an acetyl (Ac) protecting group, coupled with a 2'-O-Me-adenosine featuring a benzoyl (Bz) protecting group. These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making it valuable for biochemical research and therapeutic applications.

CAT: BRP-01160

MF: C62H70FN11O15P2

MF: 1290.25

Purity: ≥97% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: FLVRUPWUNDBISN-QKVILFJXSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((((((2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-5-(6-benzamido-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C62H70FN11O15P2/c1-39(2)74(40(3)4)90(83-33-15-30-64)88-54-49(87-60(55(54)81-8)73-38-68-52-56(66-37-67-57(52)73)71-58(76)42-17-11-9-12-18-42)36-85-91(78,84-34-16-31-65)89-53-48(86-59(51(53)63)72-32-29-50(69-41(5)75)70-61(72)77)35-82-62(43-19-13-10-14-20-43,44-21-25-46(79-6)26-22-44)45-23-27-47(80-7)28-24-45/h9-14,17-29,32,37-40,48-49,51,53-55,59-60H,15-16,33-36H2,1-8H3,(H,66,67,71,76)(H,69,70,75,77)/t48-,49-,51-,53-,54-,55-,59-,60-,90?,91?/m1/s1

Synonyms: [5'-O-(4,4'-dimethoxytrityl)-2'-Fluoro-dC(acetyl)](pCyEt)[2'-O-methyl-A(benzoyl)-3'-cyanoethyl-Phosphoramidite]; CfAm; [5'-O-DMTr-2'-F-C(Ac)](pCyEt)[2'-OMe dA(Bz)-3'-CE-Phosphoramidite]; [5'-O-DMTr-2'-F-C(Ac)](pCyEt)[2'-OMe_x005f_x0002_A(Bz)-3'-CE Phosphoramidite]

[5'-O-DMTr-2'-F-dA(Bz)](pCyEt)[2'-OMe-A(Bz)-3'-CE-Phosphoramidite]

Description: [5'-O-DMTr-2'-F-dA(Bz)](pCyEt)[2'-OMe-A(Bz)-3'-CE-Phosphoramidite] is a modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of a 5'-O-DMTr-2'-fluoro-deoxyadenosine (2'-F-dA) with a benzoyl (Bz) protecting group, coupled with a 2'-O-Me-adenosine also featuring a benzoyl (Bz) protecting group. These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making it valuable for biochemical research and therapeutic applications.

CAT: BRP-01161

MF: C68H72FN13O14P2

MF: 1376.35

Purity: ≥97% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: IEMHYBRYTKNWOB-YKZUEJCGSA-N

IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((((((2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C68H72FN13O14P2/c1-43(2)82(44(3)4)97(90-35-17-33-70)95-58-53(94-67(59(58)88-7)81-42-77-56-61(73-40-75-63(56)81)79-65(84)46-21-13-9-14-22-46)38-92-98(85,91-36-18-34-71)96-57-52(93-66(54(57)69)80-41-76-55-60(72-39-74-62(55)80)78-64(83)45-19-11-8-12-20-45)37-89-68(47-23-15-10-16-24-47,48-25-29-50(86-5)30-26-48)49-27-31-51(87-6)32-28-49/h8-16,19-32,39-44,52-54,57-59,66-67H,17-18,35-38H2,1-7H3,(H,72,74,78,83)(H,73,75,79,84)/t52-,53-,54-,57-,58-,59-,66-,67-,97?,98?/m1/s1

Synonyms: [5'-O-(4,4'-dimethoxytrityl)-2'-Fluoro-deoxyadenosine(benzoyl)](pCyEt)[2'-O-methyl-A(benzoyl)-3'-cyanoethyl-Phosphoramidite]

[5'-O-DMTr-2'-F-dG(iBu)](pCyEt)[2'-OMe-U-3'-CE-Phosphoramidite]

Description: [5'-O-DMTr-2'-F-dG(iBu)](pCyEt)[2'-OMe-U-3'-CE-Phosphoramidite] is a modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of a 5'-O-DMTr-2'-fluoro-deoxyguanosine (2'-F-dG) with an isobutyryl (iBu) protecting group, coupled with a 2'-O-Me-uridine. These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making it valuable for biochemical research and therapeutic applications.

CAT: BRP-01162

MF: C57H69FN10O16P2

MF: 1231.16

Purity: ≥97% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: XPODDDMZDAYSLB-DDOFDVFASA-N

IUPAC Name: (2R,3R,4R,5R)-2-((((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C57H69FN10O16P2/c1-34(2)51(70)64-55-63-50-46(52(71)65-55)61-33-67(50)53-45(58)47(42(81-53)31-77-57(37-15-11-10-12-16-37,38-17-21-40(74-7)22-18-38)39-19-23-41(75-8)24-20-39)84-86(73,79-30-14-27-60)80-32-43-48(83-85(78-29-13-26-59)68(35(3)4)36(5)6)49(76-9)54(82-43)66-28-25-44(69)62-56(66)72/h10-12,15-25,28,33-36,42-43,45,47-49,53-54H,13-14,29-32H2,1-9H3,(H,62,69,72)(H2,63,64,65,70,71)/t42-,43-,45-,47-,48-,49-,53-,54-,85?,86?/m1/s1

Synonyms: [5'-O-(4,4'-dimethoxytrityl)-2'-Fluoro-deoxyguanosine(isobutyryl)](pCyEt)[2'-O-methyl-U-3'-cyanoethyl-Phosphoramidite]

[5'-O-DMTr-2'-F-dG(iBu)](pCyEt)[2'-OMe-A(Bz)-3'-CE-Phosphoramidite]

Description: [5'-O-DMTr-2'-F-dG(iBu)](pCyEt)[2'-OMe-A(Bz)-3'-CE-Phosphoramidite] is a modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of a 5'-O-DMTr-2'-fluoro-deoxyguanosine (2'-F-dG) with an isobutyryl (iBu) protecting group, coupled with a 2'-O-Me-adenosine featuring a benzoyl (Bz) protecting group. These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making it valuable for biochemical research and therapeutic applications.

CAT: BRP-01163

MF: C65H74FN13O15P2

MF: 1358.33

Purity: ≥97% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: LRTYNAWUQYQBND-XLCQULBRSA-N

IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C65H74FN13O15P2/c1-39(2)59(80)75-64-74-58-52(61(82)76-64)72-38-78(58)62-50(66)53(48(91-62)34-87-65(43-20-14-11-15-21-43,44-22-26-46(84-7)27-23-44)45-24-28-47(85-8)29-25-45)94-96(83,89-33-17-31-68)90-35-49-54(93-95(88-32-16-30-67)79(40(3)4)41(5)6)55(86-9)63(92-49)77-37-71-51-56(69-36-70-57(51)77)73-60(81)42-18-12-10-13-19-42/h10-15,18-29,36-41,48-50,53-55,62-63H,16-17,32-35H2,1-9H3,(H,69,70,73,81)(H2,74,75,76,80,82)/t48-,49-,50-,53-,54-,55-,62-,63-,95?,96?/m1/s1

Synonyms: [5'-O-(4,4'-dimethoxytrityl)-2'-Fluoro-deoxyguanosine(isobutyryl)](pCyEt)[2'-O-methyl-A(benzoyl)-3'-cyanoethyl-Phosphoramidite]

[5'-O-DMTr-2'-F-dU](pCyEt)[2'-OMe-U-3'-CE-Phosphoramidite]

Description: [5'-O-DMTr-2'-F-dU](pCyEt)[2'-OMe-U-3'-CE-Phosphoramidite] is a modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of a 5'-O-DMTr-2'-fluoro-deoxyuridine (2'-F-dU), coupled with a 2'-O-Me-uridine. These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making it valuable for biochemical research and therapeutic applications.

CAT: BRP-01164

MF: C52H62FN7O16P2

MF: 1122.05

Purity: ≥97% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: HHTCFGCOBNOOGE-OSAWNNERSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluorotetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C52H62FN7O16P2/c1-33(2)60(34(3)4)77(70-29-11-25-54)75-46-41(74-49(47(46)68-7)59-28-24-43(62)57-51(59)64)32-72-78(65,71-30-12-26-55)76-45-40(73-48(44(45)53)58-27-23-42(61)56-50(58)63)31-69-52(35-13-9-8-10-14-35,36-15-19-38(66-5)20-16-36)37-17-21-39(67-6)22-18-37/h8-10,13-24,27-28,33-34,40-41,44-49H,11-12,29-32H2,1-7H3,(H,56,61,63)(H,57,62,64)/t40-,41-,44-,45-,46-,47-,48-,49-,77?,78?/m1/s1

Synonyms: [5'-O-(4,4'-dimethoxytrityl)-2'-Fluoro-deoxyuridine](pCyEt)[2'-O-methyl-U-3'-cyanoethyl-Phosphoramidite]; UfUm; [5'-O-DMTr-2'-F-U](pCyEt)[2'-OMe-U-3'-CE Phosphoramidite]

[5'-O-DMTr-2'-F-dA(Bz)](pCyEt)[2'-OMe-U-3'-CE-Phosphoramidite]

Description: [5'-O-DMTr-2'-F-dA(Bz)](pCyEt)[2'-OMe-U-3'-CE-Phosphoramidite] is a modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of a 5'-O-DMTr-2'-fluoro-deoxyadenosine (2'-F-dA) with a benzoyl (Bz) protecting group, coupled with a 2'-O-Me-uridine. These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making it valuable for biochemical research and therapeutic applications.

CAT: BRP-01165

MF: C60H67FN10O15P2

MF: 1249.20

Purity: ≥97% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: MLTDAQATQGSCMC-YJAGKEHNSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((((((2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C60H67FN10O15P2/c1-38(2)71(39(3)4)87(80-32-14-29-62)85-52-47(84-58(53(52)78-7)69-31-28-48(72)67-59(69)74)35-82-88(75,81-33-15-30-63)86-51-46(83-57(49(51)61)70-37-66-50-54(64-36-65-55(50)70)68-56(73)40-16-10-8-11-17-40)34-79-60(41-18-12-9-13-19-41,42-20-24-44(76-5)25-21-42)43-22-26-45(77-6)27-23-43/h8-13,16-28,31,36-39,46-47,49,51-53,57-58H,14-15,32-35H2,1-7H3,(H,67,72,74)(H,64,65,68,73)/t46-,47-,49-,51-,52-,53-,57-,58-,87?,88?/m1/s1

Synonyms: [5'-O-(4,4'-dimethoxytrityl)-2'-Fluoro-deoxyadenosine(benzoyl)](pCyEt)[2'-O-methyl-U-3'-cyanoethyl-Phosphoramidite]; AfUm; [5'-O-DMTr-2'-F A(Bz)](pCyEt)[2'-OMe-U-3'-CE Phosphoramidite]

[5'-O-DMTr-2'-F-dU](pCyEt)[2'-OMe-A(Bz)-3'-CE-Phosphoramidite]

Description: [5'-O-DMTr-2'-F-dU](pCyEt)[2'-OMe-A(Bz)-3'-CE-Phosphoramidite] is a modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of a 5'-O-DMTr-2'-fluoro-deoxyuridine (2'-F-dU), coupled with a 2'-O-Me-adenosine featuring a benzoyl (Bz) protecting group. These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making it valuable for biochemical research and therapeutic applications.

CAT: BRP-01166

MF: C60H67FN10O15P2

MF: 1249.20

Purity: ≥97% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: MXFDTLAJATVWHH-YJAGKEHNSA-N

IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluorotetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C60H67FN10O15P2/c1-38(2)71(39(3)4)87(80-32-14-29-62)85-52-47(84-58(53(52)78-7)70-37-66-50-54(64-36-65-55(50)70)68-56(73)40-16-10-8-11-17-40)35-82-88(75,81-33-15-30-63)86-51-46(83-57(49(51)61)69-31-28-48(72)67-59(69)74)34-79-60(41-18-12-9-13-19-41,42-20-24-44(76-5)25-21-42)43-22-26-45(77-6)27-23-43/h8-13,16-28,31,36-39,46-47,49,51-53,57-58H,14-15,32-35H2,1-7H3,(H,67,72,74)(H,64,65,68,73)/t46-,47-,49-,51-,52-,53-,57-,58-,87?,88?/m1/s1

Synonyms: [5'-O-(4,4'-dimethoxytrityl)-2'-Fluoro-deoxyuridine](pCyEt)[2'-O-methyl-A(benzoyl)-3'-cyanoethyl-Phosphoramidite]; UfAm; [5'-O-DMTr-2'-F-U](pCyEt)[2'-OMe-A(Bz)-3'-CE Phosphoramidite]

[5'-O-DMTr-2'-F-dC(Ac)](pCyEt)[2'-OMe-U-3'-CE-Phosphoramidite]

Description: [5'-O-DMTr-2'-F-dC(Ac)](pCyEt)[2'-OMe-U-3'-CE-Phosphoramidite] is a modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of a 5'-O-DMTr-2'-fluoro-deoxycytidine (2'-F-dC) with an acetyl (Ac) protecting group, coupled with a 2'-O-Me-uridine. These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making it valuable for biochemical research and therapeutic applications.

CAT: BRP-01167

MF: C54H65FN8O16P2

MF: 1163.10

Purity: ≥97% by HPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: VRMGJNPMTYRHKS-JFJKBCMNSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((((((2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C54H65FN8O16P2/c1-34(2)63(35(3)4)80(73-30-12-26-56)78-48-43(77-51(49(48)71-8)62-29-25-45(65)60-53(62)67)33-75-81(68,74-31-13-27-57)79-47-42(76-50(46(47)55)61-28-24-44(58-36(5)64)59-52(61)66)32-72-54(37-14-10-9-11-15-37,38-16-20-40(69-6)21-17-38)39-18-22-41(70-7)23-19-39/h9-11,14-25,28-29,34-35,42-43,46-51H,12-13,30-33H2,1-8H3,(H,60,65,67)(H,58,59,64,66)/t42-,43-,46-,47-,48-,49-,50-,51-,80?,81?/m1/s1

Synonyms: [5'-O-(4,4'-dimethoxytrityl)-2'-Fluoro-dC(acetyl)](pCyEt)[2'-O-methyl-U-3'-cyanoethyl-Phosphoramidite]

2-Cyanoethyl (6-(3-(prop-2-yn-1-yloxy)-2,2-bis((prop-2-yn-1-yloxy)methyl)propoxy)hexyl) diisopropylphosphoramidite

Description: This phosphoramidite is utilized in solid-phase oligonucleotide synthesis. The cyanoethyl group protects the phosphate backbone during synthesis, while the complex linker (prop-2-yn-1-yloxy and propoxy groups) allows for the attachment of nucleoside units. This modification facilitates the creation of oligonucleotides with specific functionalities and structures for various research and therapeutic applications.

CAT: BRP-01168

MF: C29H47N2O6P

MF: 550.68

Purity: ≥98% by HPLC

Appearance: Colorless, pale yellow to yellow oily matter

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InChIKey: UGCIERZKKRAEPJ-UHFFFAOYSA-N

CanonicalSMILES: N#CCCOP(OCCCCCCOCC(COCC#C)(COCC#C)COCC#C)N(C(C)C)C(C)C

InChI: InChI=1S/C29H47N2O6P/c1-8-17-32-23-29(24-33-18-9-2,25-34-19-10-3)26-35-20-13-11-12-14-21-36-38(37-22-15-16-30)31(27(4)5)28(6)7/h1-3,27-28H,11-15,17-26H2,4-7H3

TEG-GalNAc Cluster Amidite

Description: TEG-GalNAc amidite is employed in the synthesis of oligonucleotides conjugated with GalNAc clusters. GalNAc conjugation facilitates targeted delivery of oligonucleotides to hepatocytes, enhancing therapeutic efficacy in treatments for liver-related diseases such as familial hypercholesterolemia and hepatic cancers.

CAT: BRP-01169

MF: C61H89N4O19P

MF: 1213.37

Purity: ≥97% by HPLC

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InChIKey: ZBBIFTGXXMNXRH-CKGCLIAUSA-N

IUPAC Name: (2R,3R,4R,5R,6R)-5-acetamido-2-(acetoxymethyl)-6-((4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-1,1-bis(4-methoxyphenyl)-20-oxo-1-phenyl-2,6,9,12,15-pentaoxa-19-azatetracosan-24-yl)oxy)tetrahydro-2H-pyran-3,4-diyl diacetate

InChI: InChI=1S/C61H89N4O19P/c1-43(2)65(44(3)4)85(80-33-16-29-62)84-54(41-79-61(49-18-12-11-13-19-49,50-21-25-52(71-9)26-22-50)51-23-27-53(72-10)28-24-51)40-76-39-38-75-37-36-74-35-34-73-31-17-30-63-56(70)20-14-15-32-77-60-57(64-45(5)66)59(82-48(8)69)58(81-47(7)68)55(83-60)42-78-46(6)67/h11-13,18-19,21-28,43-44,54-55,57-60H,14-17,20,30-42H2,1-10H3,(H,63,70)(H,64,66)/t54?,55-,57-,58+,59-,60-,85?/m1/s1

Synonyms: tetraethylene glycol-N-acetylgalactosamine Amidite

DMTr-hydroxymethyl hexyl-Biotin Phosphoramidite

Description: This phosphoramidite incorporates biotin linked via a hydroxymethyl hexyl spacer, protected with a dimethoxytrityl (DMTr) group. Biotin is widely used in biochemical assays for affinity purification, protein detection, and as a molecular tag in nucleic acid hybridization studies. This modification enables specific and sensitive detection and isolation of biotinylated oligonucleotides or biomolecules.

CAT: BRP-01170

CAS: 1021702-07-7

MF: C47H66N5O7PS

MF: 876.11

Purity: ≥97% by UPLC

Appearance: White, off-white to faint yellow powder

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InChIKey: GMVCCUAXEMZEJE-OYSBNFJTSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OCC(CCCCNC(=O)CCCCC1C2C(CS1)NC(=O)N2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-6-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyhexyl]pentanamide

InChI: InChI=1S/C47H66N5O7PS/c1-34(2)52(35(3)4)60(58-30-14-28-48)59-32-36(15-12-13-29-49-44(53)19-11-10-18-43-45-42(33-61-43)50-46(54)51-45)31-57-47(37-16-8-7-9-17-37,38-20-24-40(55-5)25-21-38)39-22-26-41(56-6)27-23-39/h7-9,16-17,20-27,34-36,42-43,45H,10-15,18-19,29-33H2,1-6H3,(H,49,53)(H2,50,51,54)/t36?,42-,43-,45-,60?/m0/s1

Synonyms: DMTr-hydroxymethyl hexyl-Biotin Phosphoramidite; 2-[[Bis(4-methoxyphenyl)phenylmethoxy]methyl]-6-[[5-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]hexyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-6-[[5-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]hexyl 2-cyanoethyl ester

1,3-di-O-DMTr-glycerol-bis-(diisopropylamino)-Phosphane

Description: This phosphoramidite features a glycerol backbone modified with two DMTr groups and diisopropylamino phosphane groups. It facilitates efficient coupling reactions during solid-phase oligonucleotide synthesis, ensuring high purity and yield. The glycerol spacer enhances solubility and stability of synthesized oligonucleotides, crucial for applications in diagnostics, therapeutics, and biochemical research.

CAT: BRP-01171

MF: C57H71N2O7P

MF: 927.18

Purity: ≥97% by UPLC

Appearance: White, off-white to light yellow powder

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InChIKey: YMXVZHWMLGEXDA-UHFFFAOYSA-N

CanonicalSMILES: CC(N(P(N(C(C)C)C(C)C)OC(COC(C1=CC=C(OC)C=C1)(C2=CC=C(OC)C=C2)C3=CC=CC=C3)COC(C4=CC=C(OC)C=C4)(C5=CC=C(OC)C=C5)C6=CC=CC=C6)C(C)C)C

IUPAC Name: 1-((1,3-bis(bis(4-methoxyphenyl)(phenyl)methoxy)propan-2-yl)oxy)-N,N,N',N'-tetraisopropylphosphanediamine

InChI: InChI=1S/C57H71N2O7P/c1-41(2)58(42(3)4)67(59(43(5)6)44(7)8)66-55(39-64-56(45-19-15-13-16-20-45,47-23-31-51(60-9)32-24-47)48-25-33-52(61-10)34-26-48)40-65-57(46-21-17-14-18-22-46,49-27-35-53(62-11)36-28-49)50-29-37-54(63-12)38-30-50/h13-38,41-44,55H,39-40H2,1-12H3

Synonyms: 1,3-di-O-(4,4'-dimethoxytrityl)-glycerol-bis-(diisopropylamino)-Phosphane

NHMMTr-C8 Phosphoramidite

Description: NHMMTr (N-methyl-N-(4-methoxy-2,4-dimethylphenyl)aminoethyl) linked to an octyl chain serves as a phosphoramidite for oligonucleotide synthesis. This modification improves the stability and hybridization properties of synthesized oligonucleotides, making them suitable for applications such as antisense therapy, gene silencing, and diagnostics.

CAT: BRP-01172

MF: C37H52N3O3P

MF: 617.81

Purity: ≥97% by UPLC

Appearance: Colorless to light yellow oily matter

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InChIKey: WQNVNSOXLICQQJ-UHFFFAOYSA-N

CanonicalSMILES: N#CCCOP(N(C(C)C)C(C)C)OCCCCCCCCNC(C1=CC=CC=C1)(C2=CC=C(OC)C=C2)C3=CC=CC=C3

IUPAC Name: 2-cyanoethyl (8-(((4-methoxyphenyl)diphenylmethyl)amino)octyl) diisopropylphosphoramidite

InChI: InChI=1S/C37H52N3O3P/c1-31(2)40(32(3)4)44(43-30-18-27-38)42-29-17-9-7-6-8-16-28-39-37(33-19-12-10-13-20-33,34-21-14-11-15-22-34)35-23-25-36(41-5)26-24-35/h10-15,19-26,31-32,39H,6-9,16-18,28-30H2,1-5H3

Synonyms: Monomethoxytrityl-octylamine-linker Phosphoramidite; MMTr C8 amine amidite

12-O-DMTr-dodecane-bis-(diisopropylamino)-Phosphane

Description: This phosphoramidite incorporates a dodecane spacer with two DMTr groups and diisopropylamino phosphane groups. It facilitates the attachment of nucleoside units during oligonucleotide synthesis, ensuring efficient coupling and high purity of the final product. The dodecane spacer provides flexibility and stability to synthesized oligonucleotides, essential for biomedical and research applications.

CAT: BRP-01173

MF: C45H71N2O4P

MF: 735.05

Purity: ≥97% by HPLC

Appearance: Colorless to light yellow oily matter

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InChIKey: RQZBDCUKNIMBGS-UHFFFAOYSA-N

CanonicalSMILES: CC(N(C(C)C)P(OCCCCCCCCCCCCOC(C1=CC=CC=C1)(C2=CC=C(OC)C=C2)C3=CC=C(C=C3)OC)N(C(C)C)C(C)C)C

IUPAC Name: 1-((12-(bis(4-methoxyphenyl)(phenyl)methoxy)dodecyl)oxy)-N,N,N',N'-tetraisopropylphosphanediamine

InChI: InChI=1S/C45H71N2O4P/c1-36(2)46(37(3)4)52(47(38(5)6)39(7)8)51-35-23-18-16-14-12-11-13-15-17-22-34-50-45(40-24-20-19-21-25-40,41-26-30-43(48-9)31-27-41)42-28-32-44(49-10)33-29-42/h19-21,24-33,36-39H,11-18,22-23,34-35H2,1-10H3

Synonyms: 12-O-(4,4'-dimethoxytrityl)-dodecane-bis-(diisopropylamino)-Phosphane

N-Butyl-2-cyanoethyl-N,N-diisopropylphosphoramidite

Description: This phosphoramidite derivative contains a butyl group, cyanoethyl protecting group, and diisopropylphosphoramidite functionality for coupling nucleoside units in oligonucleotide synthesis. It enhances the efficiency and specificity of nucleotide incorporation, enabling the synthesis of customized oligonucleotides for gene expression studies, RNA interference, and therapeutic applications.

CAT: BRP-01174

CAS: 887265-03-4

MF: C13H27N2O2P

MF: 274.34

Purity: >95%

Appearance: Colorless to light yellow oily matter

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InChIKey: IICOXFTVYLVMBH-UHFFFAOYSA-N

CanonicalSMILES: CCCCOP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: 3-[butoxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C13H27N2O2P/c1-6-7-10-16-18(17-11-8-9-14)15(12(2)3)13(4)5/h12-13H,6-8,10-11H2,1-5H3

Synonyms: Butyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, butyl 2-cyanoethyl ester; Butyl (2-cyanoethyl) diisopropylphosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, butyl 2-cyanoethyl ester

Cholesterol tetraethylene glycol (TetraEG) amidite

Description: Cholesterol linked to tetraethylene glycol (TetraEG) serves as an amidite for synthesizing cholesterol-conjugated oligonucleotides. This modification enhances cellular uptake and plasma stability of oligonucleotides, making them suitable for targeted delivery and therapeutic applications in treating cardiovascular diseases and metabolic disorders.

CAT: BRP-01175

CAS: 902153-15-5

MF: C48H86N3O8P

MF: 864.20

Purity: ≥97% by HPLC

Appearance: Colorless to faint yellow oily matter

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InChIKey: LWVRDTCTOJPCKR-UFMWMBMBSA-N

CanonicalSMILES: N#CCCOP(OCCOCCOCCOCCOCCCNC(=O)OC1CC2=CCC3C(CCC4(C)C(CCC34)C(C)CCCC(C)C)C2(C)CC1)N(C(C)C)C(C)C

IUPAC Name: (3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl (1-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-3,6,9,12-tetraoxapentadecan-15-yl)carbamate

InChI: InChI=1S/C48H86N3O8P/c1-36(2)13-10-14-39(7)43-17-18-44-42-16-15-40-35-41(19-21-47(40,8)45(42)20-22-48(43,44)9)59-46(52)50-24-12-25-53-27-28-54-29-30-55-31-32-56-33-34-58-60(57-26-11-23-49)51(37(3)4)38(5)6/h15,36-39,41-45H,10-14,16-22,24-35H2,1-9H3,(H,50,52)/t39-,41+,42+,43-,44+,45+,47+,48-,60?/m1/s1

Synonyms: Cholesterol tetraethylene glycol (TetraEG) amidite (plant source); Cholest-5-en-3-ol (3β)-, 19-[bis(1-methylethyl)amino]-22-cyano-6,9,12,15,18,20-hexaoxa-2-aza-19-phosphadocosanoate; Cholesterol (Plant) TEG CE phosphoramidite

5-O-DMTr-1-O-Bz-2-O-Me-ribofuranose-3-CE-Phosphoramidite

Description: This phosphoramidite is used in solid-phase synthesis of oligonucleotides where the ribofuranose sugar is modified with a dimethoxytrityl (DMTr) group on the 5'-hydroxyl, a benzoyl (Bz) group on the 1'-hydroxyl, and a methyl (Me) group on the 2'-position. These modifications provide stability and protection during synthesis, allowing for the creation of custom sequences for research and diagnostic applications.

CAT: BRP-01176

MF: C43H51N2O9P

MF: 770.85

Purity: ≥95% by UPLC

Appearance: White, off-white to light yellow powder

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InChIKey: DSCOSSQZAIEQAY-QXSSZZJWSA-N

IUPAC Name: (3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-3-methoxytetrahydrofuran-2-yl benzoate

InChI: InChI=1S/C43H51N2O9P/c1-30(2)45(31(3)4)55(51-28-14-27-44)54-39-38(52-42(40(39)49-7)53-41(46)32-15-10-8-11-16-32)29-50-43(33-17-12-9-13-18-33,34-19-23-36(47-5)24-20-34)35-21-25-37(48-6)26-22-35/h8-13,15-26,30-31,38-40,42H,14,28-29H2,1-7H3/t38-,39-,40-,42?,55?/m1/s1

Synonyms: 5-O-(4,4'-dimethoxytrityl)-1-O-benzoyl-2-O-methyl-ribofuranose-3-cyanoethyl Phosphoramidite