Phosphoramidites - RNA / BOC Sciences

Cholesteryl succinate, TEA salt (plant source)

Description: Cholesteryl succinate, TEA salt (plant source), refers to a compound derived from plants that combines cholesteryl (a cholesterol derivative) with succinic acid, forming a salt stabilized with triethylamine (TEA). This compound is utilized in various biochemical and pharmaceutical applications, particularly in lipid research and drug delivery systems. Cholesteryl derivatives are known for their ability to interact with lipid membranes and cellular structures, making them valuable in studies involving liposomes, lipid-based nanoparticles, and drug formulation.

CAT: BRP-01243

MF: C61H86O9 (free acid)

MF: 963.35 (free acid)

Purity: ≥98% by HPLC

Appearance: Colorless to faint yellow oily matter

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Storage: Store at -20 °C

IUPAC Name: 4-((1-(bis(4-methoxyphenyl)(phenyl)methoxy)-3-((6-(((3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)hexyl)oxy)propan-2-yl)oxy)-4-oxobutanoic acid;N,N-diethylethanamine

Synonyms: 1-(4,4'-Dimethoxytrityloxy)-3-(6-(Cholest-5-en-3β-oxy)hexyloxy) propan-2-succinate, triethylamine salt (plant source)

3'-Thio modifier 6 S-S-DMTr-linker-succinate, TEA salt

Description: 3'-Thio modifier 6 S-S-DMTr-linker-succinate, TEA salt, is a specialized chemical compound used in nucleic acid synthesis and modification. The salt form is stabilized with triethylamine (TEA), enhancing its stability and solubility in aqueous solutions commonly used in biochemical research. This compound is crucial in nucleoside chemistry for introducing modifications at the 3' end of nucleic acids, which can alter their stability, interaction properties, or enzymatic resistance. Such modifications are valuable in studies aiming to understand RNA or DNA structure-function relationships, in nucleic acid-based technologies, and in the development of therapeutic oligonucleotides.

CAT: BRP-01244

MF: C35H44O9S2 (free acid)

MF: 672.85 (free acid)

Purity: ≥98% by HPLC

Appearance: White, off-white to faint yellow powder

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IUPAC Name: 4-[2-[3-[3-[2-[bis(4-methoxyphenyl)-phenylmethoxy]ethoxy]propyldisulfanyl]propoxy]ethoxy]-4-oxobutanoic acid;N,N-diethylethanamine

Synonyms: 1-O-Dimethoxytrityl-3-oxahexyl-disulfide 1'-succinate, triethylamine salt; 1,1-bis(4-methoxyphenyl)-18-oxo-1-phenyl-2,5,14,17-tetraoxa-9,10-dithiahenicosan-21-oic acid, triethylamine salt

Cholesteryl-TEG-succinate (plant source)

Description: Cholesteryl-TEG-succinate (plant source) is a compound derived from plants that combines cholesteryl (a derivative of cholesterol) with succinic acid, incorporating a tetraethylene glycol (TEG) linker. This structure is designed to enhance the solubility and stability of cholesteryl in aqueous solutions, making it suitable for various applications in biochemical and pharmaceutical research. In biochemical studies, cholesteryl derivatives are utilized to investigate lipid-protein interactions, lipid-based drug delivery systems, and the formation of liposomes. The addition of a TEG linker further improves the compound's solubility and allows for conjugation with other molecules or attachment to surfaces, potentially facilitating its use in drug delivery vehicles or biomaterials.

CAT: BRP-01245

CAS: 873435-28-0

MF: C65H93NO13

MF: 1096.45

Purity: ≥98% by HPLC

Appearance: Colorless to faint yellow oily matter

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Storage: Store at -20 °C

InChIKey: YSSIXSBUMAIUOE-MFCMZYHHSA-N

IUPAC Name: 17-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-1-(((3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)-1,19-dioxo-6,9,12,15,18-pentaoxa-2-azadocosan-22-oic acid

InChI: InChI=1S/C65H93NO13/c1-46(2)13-11-14-47(3)57-27-28-58-56-26-21-51-43-54(31-33-63(51,4)59(56)32-34-64(57,58)5)79-62(70)66-35-12-36-73-37-38-74-39-40-75-41-42-76-44-55(78-61(69)30-29-60(67)68)45-77-65(48-15-9-8-10-16-48,49-17-22-52(71-6)23-18-49)50-19-24-53(72-7)25-20-50/h8-10,15-25,46-47,54-59H,11-14,26-45H2,1-7H3,(H,66,70)(H,67,68)/t47-,54+,55?,56+,57-,58+,59+,63+,64-/m1/s1

Synonyms: Cholest-5-en-3-ol (3β)-, 3-(22-hydrogen 17-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-19-oxo-6,9,12,15,18-pentaoxa-2-azadocosanedioate)

2',3'-Diacetyl Guanosine (n-ibu) CED phosphoramidite

Description: 2',3'-Diacetyl Guanosine (n-ibu) CED phosphoramidite is a chemically modified guanosine nucleotide used in oligonucleotide synthesis. Featuring acetyl groups at the 2' and 3' positions and a CED (cyanoethyl diisopropylamino) phosphoramidite group, it facilitates the creation of stable, high-fidelity DNA and RNA sequences for advanced genetic research and biotechnological applications.

CAT: BRP-01255

CAS: 1350450-67-7

MF: C27H40N7O9P

MF: 637.63

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InChIKey: IGPBVQCAEJGBML-KIDUIKHZSA-N

CanonicalSMILES: N#CCCOP(OCC1OC(N2C=NC=3C(=O)N=C(NC(=O)C(C)C)NC32)C(OC(=O)C)C1OC(=O)C)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-2-((((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate

InChI: InChI=1S/C27H40N7O9P/c1-14(2)24(37)31-27-30-23-20(25(38)32-27)29-13-33(23)26-22(42-18(8)36)21(41-17(7)35)19(43-26)12-40-44(39-11-9-10-28)34(15(3)4)16(5)6/h13-16,19,21-22,26H,9,11-12H2,1-8H3,(H2,30,31,32,37,38)/t19-,21-,22-,26-,44?/m1/s1

Synonyms: Guanosine, N-(2-methyl-1-oxopropyl)-, 2',3'-diacetate 5'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

2',3'-Diacetyl Uridine CED phosphoramidite

Description: 2',3'-Diacetyl Uridine CED phosphoramidite is a modified uridine nucleotide used in the synthesis of RNA and DNA oligonucleotides. It has acetyl groups at the 2' and 3' positions and a CED (cyanoethyl diisopropylamino) phosphoramidite group, enabling the production of stable and high-fidelity nucleic acid sequences for genetic research and biotechnological applications.

CAT: BRP-01256

CAS: 208655-84-9

MF: C22H33N4O9P

MF: 528.49

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InChIKey: QUNYGIBAHMVXKK-UZKKNRNZSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OCC1C(C(C(O1)N2C=CC(=O)NC2=O)OC(=O)C)OC(=O)C

IUPAC Name: [(2R,3R,4R,5R)-4-acetyloxy-2-[[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxymethyl]-5-(2,4-dioxopyrimidin-1-yl)oxolan-3-yl] acetate

InChI: InChI=1S/C22H33N4O9P/c1-13(2)26(14(3)4)36(31-11-7-9-23)32-12-17-19(33-15(5)27)20(34-16(6)28)21(35-17)25-10-8-18(29)24-22(25)30/h8,10,13-14,17,19-21H,7,11-12H2,1-6H3,(H,24,29,30)/t17-,19-,20-,21-,36?/m1/s1

Synonyms: Uridine, 2',3'-diacetate 5'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; Uridine, 2',3'-diacetate 5'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; (2R,3R,4R,5R)-2-((((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate

2'-O-butyne Uridine CED phosphoramidite

Description: 2'-O-butyne Uridine CED phosphoramidite is a chemical compound used in oligonucleotide synthesis. It is a derivative of uridine, where the 2' position of the ribose sugar is modified with a butyne group (-C≡C-) and is functionalized with a CED (2-cyanoethyl diisopropylphosphoramidite) moiety. This modification allows for the selective incorporation of the modified uridine into the growing nucleotide chain during solid-phase synthesis of oligonucleotides. The presence of the butyne group enables further chemical reactions for the conjugation of various functional groups or molecules. This compound plays a crucial role in the design and synthesis of specialized oligonucleotides for applications in molecular biology, diagnostics, and therapeutics.

CAT: BRP-01258

CAS: 2305570-48-1

MF: C43H51N4O9P

MF: 798.86

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InChIKey: IZIBOIGAGRJZFP-QBLJBMGASA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=CC(=O)NC2=O)C1OCC#CC)COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(but-2-yn-1-yloxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C43H51N4O9P/c1-8-9-27-52-40-39(56-57(54-28-13-25-44)47(30(2)3)31(4)5)37(55-41(40)46-26-24-38(48)45-42(46)49)29-53-43(32-14-11-10-12-15-32,33-16-20-35(50-6)21-17-33)34-18-22-36(51-7)23-19-34/h10-12,14-24,26,30-31,37,39-41H,13,27-29H2,1-7H3,(H,45,48,49)/t37-,39-,40-,41-,57?/m1/s1

Synonyms: 5'-O-DMTr-2'-O-butyne-U-3'-CE-Phosphoramidite

2'-O-butyne Adenosine (n-bz) CED phosphoramidite

Description: 2'-O-butyne Adenosine (n-bz) CED phosphoramidite is a specialized compound used in oligonucleotide synthesis. It consists of an adenosine nucleoside with a modification at the 2' position of the ribose sugar, where a butyne (-C≡C-) group is attached. Additionally, it features a benzoyl (n-bz) group to protect the amino group at the N6 position of adenine and a CED (2-cyanoethyl diisopropylphosphoramidite) moiety. This modification enables the selective incorporation of the modified adenosine into the growing nucleotide chain during solid-phase synthesis of oligonucleotides. The presence of the butyne group allows for further functionalization or conjugation, making it useful for various applications in molecular biology, diagnostics, and therapeutics.

CAT: BRP-01259

MF: C51H56N7O8P

MF: 926.01

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InChIKey: FNMMYMFLDRVDOX-LTMMGAFGSA-N

IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(but-2-yn-1-yloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C51H56N7O8P/c1-8-9-30-62-46-45(66-67(64-31-16-29-52)58(35(2)3)36(4)5)43(65-50(46)57-34-55-44-47(53-33-54-48(44)57)56-49(59)37-17-12-10-13-18-37)32-63-51(38-19-14-11-15-20-38,39-21-25-41(60-6)26-22-39)40-23-27-42(61-7)28-24-40/h10-15,17-28,33-36,43,45-46,50H,16,30-32H2,1-7H3,(H,53,54,56,59)/t43-,45-,46-,50-,67?/m1/s1

Synonyms: 5'-O-DMTr-2'-O-butyne-A(Bz)-3'-CE-Phosphoramidite

2'-O-butyne Guanosine (n-ibu) CED phosphoramidite

Description: 2'-O-butyne Guanosine (n-ibu) CED phosphoramidite is a specialized compound utilized in oligonucleotide synthesis. It consists of a guanosine nucleoside with a modification at the 2' position of the ribose sugar, where a butyne (-C≡C-) group is attached. Additionally, it features an isobutyryl (n-ibu) group to protect the amino group at the N2 position of guanine and a CED (2-cyanoethyl diisopropylphosphoramidite) moiety. This modification allows for the selective incorporation of the modified guanosine into the growing nucleotide chain during solid-phase synthesis of oligonucleotides. The presence of the butyne group enables further functionalization or conjugation, making it valuable for various applications in molecular biology, diagnostics, and therapeutics.

CAT: BRP-01260

MF: C48H58N7O9P

MF: 907.99

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InChIKey: ABJZHECXWHOPKB-VKFKYRIUSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(but-2-yn-1-yloxy)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C48H58N7O9P/c1-10-11-27-60-42-41(64-65(62-28-15-26-49)55(32(4)5)33(6)7)39(63-46(42)54-30-50-40-43(54)51-47(53-45(40)57)52-44(56)31(2)3)29-61-48(34-16-13-12-14-17-34,35-18-22-37(58-8)23-19-35)36-20-24-38(59-9)25-21-36/h12-14,16-25,30-33,39,41-42,46H,15,27-29H2,1-9H3,(H2,51,52,53,56,57)/t39-,41-,42-,46-,65?/m1/s1

Synonyms: 5'-O-DMTr-2'-O-butyne-G(iBu)-3'-CE-Phosphoramidite

2'-O-butyne Cytidine (n-bz) CED phosphoramidite

Description: 2'-O-butyne Cytidine (n-bz) CED phosphoramidite is a specialized reagent used in oligonucleotide synthesis. It consists of a cytidine nucleoside modified with a 2'-O-butyne group and protected with a benzoyl (n-bz) group. Additionally, it contains a CED (2-cyanoethyl diisopropylphosphoramidite) moiety, which serves as a protecting group during the synthesis process. This phosphoramidite derivative allows for efficient and selective incorporation of the modified cytidine into the growing nucleotide chain during solid-phase synthesis. The presence of the butyne group enables further chemical reactions for the conjugation of various functional groups or molecules. This compound plays a crucial role in the design and synthesis of specialized oligonucleotides for applications in molecular biology, diagnostics, and therapeutics.

CAT: BRP-01265

MF: C50H56N5O9P

MF: 901.98

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InChIKey: ZCJRISCCQSIUEK-BZESDKEVSA-N

IUPAC Name: (2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(but-2-yn-1-yloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C50H56N5O9P/c1-8-9-32-60-46-45(64-65(62-33-16-30-51)55(35(2)3)36(4)5)43(63-48(46)54-31-29-44(53-49(54)57)52-47(56)37-17-12-10-13-18-37)34-61-50(38-19-14-11-15-20-38,39-21-25-41(58-6)26-22-39)40-23-27-42(59-7)28-24-40/h10-15,17-29,31,35-36,43,45-46,48H,16,32-34H2,1-7H3,(H,52,53,56,57)/t43-,45-,46-,48-,65?/m1/s1

Synonyms: 5'-O-DMTr-2'-O-butyne-C(Bz)-3'-CE-Phosphoramidite

2'-O-Methyl Guanosine (n-PAC) CED phosphoramidite

Description: 2'-O-Methyl Guanosine (n-PAC) CED phosphoramidite is a specialized reagent used in oligonucleotide synthesis. It consists of a guanosine nucleoside modified with a 2'-O-Methyl group and protected with a PAC (phenoxyacetyl) group. Additionally, it contains a CED (2-cyanoethyl diisopropylphosphoramidite) moiety, which serves as a protecting group during the synthesis process. This phosphoramidite derivative allows for efficient and selective incorporation of the modified guanosine into the growing nucleotide chain during solid-phase synthesis. The presence of the 2'-O-Methyl group provides stability and can influence the properties of the resulting oligonucleotide. This compound is essential in the design and synthesis of modified oligonucleotides for various applications in molecular biology, diagnostics, and therapeutics.

CAT: BRP-01267

CAS: 138906-79-3

MF: C49H56N7O10P

MF: 933.96

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InChIKey: FBLBODSDYPHQTB-KPWHVHSNSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C(=O)N=C(NC(=O)COC=4C=CC=CC4)NC32)C1OC)COC(C=5C=CC=CC5)(C6=CC=C(OC)C=C6)C7=CC=C(OC)C=C7)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxy-5-(6-oxo-2-(2-phenoxyacetamido)-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C49H56N7O10P/c1-32(2)56(33(3)4)67(64-28-14-27-50)66-43-40(29-63-49(34-15-10-8-11-16-34,35-19-23-37(59-5)24-20-35)36-21-25-38(60-6)26-22-36)65-47(44(43)61-7)55-31-51-42-45(55)53-48(54-46(42)58)52-41(57)30-62-39-17-12-9-13-18-39/h8-13,15-26,31-33,40,43-44,47H,14,28-30H2,1-7H3,(H2,52,53,54,57,58)/t40-,43-,44-,47-,67?/m1/s1

Synonyms: 5'-O-DMTr-2'-O-Methyl-G(Pac)-3'-CE-Phosphoramidite; Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-N-(phenoxyacetyl)-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

MMT-2'-O-Methyl Adenosine (n-bz) CED phosphoramidite

Description: MMT-2'-O-Methyl Adenosine (n-bz) CED phosphoramidite is a specialized reagent used in oligonucleotide synthesis. It consists of an adenosine nucleoside modified with a 2'-O-Methyl group and protected with a benzoyl (n-bz) group. Additionally, it contains a CED (2-cyanoethyl diisopropylphosphoramidite) moiety, which serves as a protecting group during the synthesis process. The MMT (Monomethoxytrityl) group is typically used for temporary protection of hydroxyl groups in nucleosides. This phosphoramidite derivative allows for efficient and selective incorporation of the modified adenosine into the growing nucleotide chain during solid-phase synthesis. This compound is crucial in the design and synthesis of modified oligonucleotides for various applications in molecular biology, diagnostics, and therapeutics.

CAT: BRP-01270

CAS: 2645354-88-5

MF: C47H52N7O7P

MF: 857.93

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InChIKey: GBMKDKSAHVWHSY-JIUDHRTHSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C(=NC=NC32)NC(=O)C=4C=CC=CC4)C1OC)COC(C=5C=CC=CC5)(C=6C=CC=CC6)C7=CC=C(OC)C=C7)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-4-methoxy-2-(((4-methoxyphenyl)diphenylmethoxy)methyl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C47H52N7O7P/c1-32(2)54(33(3)4)62(59-28-16-27-48)61-41-39(29-58-47(35-19-12-8-13-20-35,36-21-14-9-15-22-36)37-23-25-38(56-5)26-24-37)60-46(42(41)57-6)53-31-51-40-43(49-30-50-44(40)53)52-45(55)34-17-10-7-11-18-34/h7-15,17-26,30-33,39,41-42,46H,16,28-29H2,1-6H3,(H,49,50,52,55)/t39-,41-,42-,46-,62?/m1/s1

Synonyms: 5'-O-MMTr-2'-O-Methyl-A(Bz)-3'-CE-Phosphoramidite

MMT-2'-O-Methyl Guanosine (n-ibu) CED phosphoramidite

Description: MMT-2'-O-Methyl Guanosine (n-ibu) CED phosphoramidite is a specialized reagent employed in oligonucleotide synthesis. It features a guanosine nucleoside with a 2'-O-Methyl modification, protected by an isobutyryl (n-ibu) group, and coupled with a CED (2-cyanoethyl diisopropylphosphoramidite) moiety. The MMT (Monomethoxytrityl) group temporarily shields hydroxyl groups in nucleosides during synthesis. This phosphoramidite enables precise incorporation of the modified guanosine into nucleotide chains during solid-phase synthesis, vital for tailored oligonucleotide design in molecular biology, diagnostics, and therapeutics.

CAT: BRP-01271

CAS: 110782-32-6

MF: C44H54N7O8P

MF: 839.92

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InChIKey: FJAOBUANVXIWLD-FRQJXJFPSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C(=O)N=C(NC(=O)C(C)C)NC32)C1OC)COC(C=4C=CC=CC4)(C=5C=CC=CC5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C

IUPAC Name: 2-cyanoethyl ((2R,3R,4R,5R)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-methoxy-2-(((4-methoxyphenyl)diphenylmethoxy)methyl)tetrahydrofuran-3-yl) diisopropylphosphoramidite

InChI: InChI=1S/C44H54N7O8P/c1-28(2)40(52)48-43-47-39-36(41(53)49-43)46-27-50(39)42-38(55-8)37(59-60(57-25-15-24-45)51(29(3)4)30(5)6)35(58-42)26-56-44(31-16-11-9-12-17-31,32-18-13-10-14-19-32)33-20-22-34(54-7)23-21-33/h9-14,16-23,27-30,35,37-38,42H,15,25-26H2,1-8H3,(H2,47,48,49,52,53)/t35-,37-,38-,42-,60?/m1/s1

Synonyms: Guanosine, 5'-O-[(4-methoxyphenyl)diphenylmethyl]-2'-O-methyl-N-(2-methyl-1-oxopropyl)-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; 5'-O-MMTr-2'-O-Methyl-G(iBu)-3'-CE-Phosphoramidite

2'-O-Methyl Cytidine (N-PAC) 3'-O-BMEG phosphoramidite

Description: 2'-O-Methyl Cytidine (N-PAC) 3'-O-BMEG phosphoramidite is utilized in oligonucleotide synthesis. It involves a cytidine nucleoside that has been modified with a 2'-O-Methyl group, protected with a PAC group (phenoxyacetyl), and coupled with a 3'-O-BMEG (3'-O-benzyl-2'-O-methyl-2'-O-(2-cyanoethyl) guanosine) phosphoramidite. It facilitates the precise incorporation of modified cytidine into nucleotide chains during solid-phase synthesis, critical for various applications in molecular biology, genetics, diagnostics, and therapeutics.

CAT: BRP-01274

MF: C53H67N4O12PS

MF: 1015.16

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InChIKey: BDDJICCPICJTLQ-KLVGKUQJSA-N

IUPAC Name: S-(2-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxy-5-(2-oxo-4-(2-phenoxyacetamido)pyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethoxy)ethyl) 2-methylpropanethioate

InChI: InChI=1S/C53H67N4O12PS/c1-36(2)51(59)71-33-32-64-30-31-67-70(57(37(3)4)38(5)6)69-48-45(68-50(49(48)63-9)56-29-28-46(55-52(56)60)54-47(58)35-65-44-18-14-11-15-19-44)34-66-53(39-16-12-10-13-17-39,40-20-24-42(61-7)25-21-40)41-22-26-43(62-8)27-23-41/h10-29,36-38,45,48-50H,30-35H2,1-9H3,(H,54,55,58,60)/t45-,48-,49-,50-,70?/m1/s1

Synonyms: 5'-O-DMTr-2'-O-Methyl-C(Pac)-3'-O-BMEG phosphoramidite

2'-O-Methyl Guanosine (N-iPrPAC) 3'-O-BMEG phosphoramidite

Description: 2'-O-Methyl Guanosine (N-iPrPAC) 3'-O-BMEG phosphoramidite is used in oligonucleotide synthesis. It consists of a guanosine nucleoside modified with a 2'-O-Methyl group, protected with an isopropylphenoxyacetyl (iPr-Pac) group, and coupled with a 3'-O-BMEG phosphoramidite. It enables controlled and efficient incorporation of modified guanosine into oligonucleotide sequences, crucial for tailored oligonucleotide design in various biological applications.

CAT: BRP-01275

MF: C57H73N6O12PS

MF: 1097.26

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InChIKey: CXMDDZTWWYKURH-PZUNXSRFSA-N

IUPAC Name: S-(2-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-(2-(4-isopropylphenoxy)acetamido)-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethoxy)ethyl) 2-methylpropanethioate

InChI: InChI=1S/C57H73N6O12PS/c1-36(2)40-17-23-46(24-18-40)71-34-48(64)59-56-60-52-49(53(65)61-56)58-35-62(52)54-51(69-11)50(75-76(63(38(5)6)39(7)8)73-30-29-70-31-32-77-55(66)37(3)4)47(74-54)33-72-57(41-15-13-12-14-16-41,42-19-25-44(67-9)26-20-42)43-21-27-45(68-10)28-22-43/h12-28,35-39,47,50-51,54H,29-34H2,1-11H3,(H2,59,60,61,64,65)/t47-,50-,51-,54-,76?/m1/s1

Synonyms: 5'-O-DMTr-2'-O-Methyl-G(iPr-Pac)-3'-O-BMEG phosphoramidite

2'-O-Methyl Uridine 3'-O-BMEG phosphoramidite

Description: 2'-O-Methyl Uridine 3'-O-BMEG phosphoramidite is employed in oligonucleotide synthesis. It features a uridine nucleoside modified with a 2'-O-Methyl group and coupled with a 3'-O-BMEG phosphoramidite. It enables the precise incorporation of modified uridine into nucleotide chains during solid-phase synthesis, facilitating the design and synthesis of specialized oligonucleotides for use in molecular biology, genetics, diagnostics, and therapeutics.

CAT: BRP-01276

CAS: 1219597-71-3

MF: C45H60N3O11PS

MF: 882.01

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InChIKey: REAOWVIOVQIPDP-FSEQMNGPSA-N

CanonicalSMILES: CC(C)C(=O)SCCOCCOP(N(C(C)C)C(C)C)OC1C(OC(C1OC)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: S-[2-[2-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(2,4-dioxopyrimidin-1-yl)-4-methoxyoxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxyethoxy]ethyl] 2-methylpropanethioate

InChI: InChI=1S/C45H60N3O11PS/c1-30(2)43(50)61-28-27-55-25-26-57-60(48(31(3)4)32(5)6)59-40-38(58-42(41(40)54-9)47-24-23-39(49)46-44(47)51)29-56-45(33-13-11-10-12-14-33,34-15-19-36(52-7)20-16-34)35-17-21-37(53-8)22-18-35/h10-24,30-32,38,40-42H,25-29H2,1-9H3,(H,46,49,51)/t38-,40-,41-,42-,60?/m1/s1

Synonyms: S-(2-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethoxy)ethyl) 2-methylpropanethioate; 5'-O-DMTr-2'-O-Methyl-U-3'-O-BMEG phosphoramidite

2'-O-Methyl Adenosine (N-PAC) 3'-O-BMEG phosphoramidite

Description: 2'-O-Methyl Adenosine (N-PAC) 3'-O-BMEG phosphoramidite is utilized in oligonucleotide synthesis. It comprises an adenosine nucleoside modified with a 2'-O-Methyl group and protected with a PAC group (phenoxyacetyl), coupled with a 3'-O-BMEG (3'-O-benzyl-2'-O-methyl-2'-O-(2-cyanoethyl) guanosine) phosphoramidite. It facilitates precise incorporation of modified adenosine into nucleotide chains during solid-phase synthesis, critical for various applications in molecular biology, genetics, diagnostics, and therapeutics.

CAT: BRP-01277

CAS: 1219597-69-9

MF: C54H67N6O11PS

MF: 1039.18

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InChIKey: DZVZJNHAUNNRRG-JHMFWHMXSA-N

CanonicalSMILES: CC(C)C(=O)SCCOCCOP(N(C(C)C)C(C)C)OC1C(OC(C1OC)N2C=NC3=C(N=CN=C32)NC(=O)COC4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC

IUPAC Name: S-[2-[2-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-methoxy-5-[6-[(2-phenoxyacetyl)amino]purin-9-yl]oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxyethoxy]ethyl] 2-methylpropanethioate

InChI: InChI=1S/C54H67N6O11PS/c1-36(2)53(62)73-31-30-66-28-29-69-72(60(37(3)4)38(5)6)71-48-45(32-68-54(39-16-12-10-13-17-39,40-20-24-42(63-7)25-21-40)41-22-26-43(64-8)27-23-41)70-52(49(48)65-9)59-35-57-47-50(55-34-56-51(47)59)58-46(61)33-67-44-18-14-11-15-19-44/h10-27,34-38,45,48-49,52H,28-33H2,1-9H3,(H,55,56,58,61)/t45-,48-,49-,52-,72?/m1/s1

Synonyms: 5'-O-DMTr-2'-O-Methyl-A(Pac)-3'-O-BMEG phosphoramidite; S-(2-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxy-5-(6-(2-phenoxyacetamido)-9H-purin-9-yl)tetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethoxy)ethyl) 2-methylpropanethioate; Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-N-(2-phenoxyacetyl)-, 3'-[2-[2-[(2-methyl-1-oxopropyl)thio]ethoxy]ethyl N,N-bis(1-methylethyl)phosphoramidite]

2'-O-Methyl Adenosine (n-bz) ethyl phosphoramidite

Description: 2'-O-Methyl Adenosine (n-bz) ethyl phosphoramidite is used in oligonucleotide synthesis. It involves an adenosine nucleoside modified with a 2'-O-Methyl group and protected with a benzoyl (n-bz) group, coupled with an ethyl phosphoramidite. It enables controlled and efficient incorporation of modified adenosine into oligonucleotide sequences, crucial for tailored oligonucleotide design in various biological applications.

CAT: BRP-01278

CAS: 179478-97-8

MF: C47H55N6O8P

MF: 862.95

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InChIKey: UGNHWRCMCLTGDV-JIUDHRTHSA-N

CanonicalSMILES: O=C(NC1=NC=NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP(OCC)N(C(C)C)C(C)C)C3OC)C=7C=CC=CC7

IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl ethyl diisopropylphosphoramidite

InChI: InChI=1S/C47H55N6O8P/c1-9-59-62(53(31(2)3)32(4)5)61-41-39(60-46(42(41)57-8)52-30-50-40-43(48-29-49-44(40)52)51-45(54)33-16-12-10-13-17-33)28-58-47(34-18-14-11-15-19-34,35-20-24-37(55-6)25-21-35)36-22-26-38(56-7)27-23-36/h10-27,29-32,39,41-42,46H,9,28H2,1-8H3,(H,48,49,51,54)/t39-,41-,42-,46-,62?/m1/s1

Synonyms: Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[ethyl bis(1-methylethyl)phosphoramidite]; 5'-O-DMTr-2'-O-Methyl-A(Bz) ethyl phosphoramidite

2'-O-Methyl Cytidine (n-bz) ethyl phosphoramidite

Description: 2'-O-Methyl Cytidine (n-bz) ethyl phosphoramidite is employed in oligonucleotide synthesis. It consists of a cytidine nucleoside modified with a 2'-O-Methyl group, protected with a benzoyl (n-bz) group, and coupled with an ethyl phosphoramidite. It facilitates the precise incorporation of modified cytidine into nucleotide chains during solid-phase synthesis, facilitating the design and synthesis of specialized oligonucleotides for use in molecular biology, genetics, diagnostics, and therapeutics.

CAT: BRP-01279

CAS: 179478-98-9

MF: C46H55N4O9P

MF: 838.93

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InChIKey: LZRBPQBDBLCFDX-ZRLRMURESA-N

CanonicalSMILES: O=C1N=C(C=CN1C2OC(COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)C(OP(OCC)N(C(C)C)C(C)C)C2OC)NC(=O)C=6C=CC=CC6

IUPAC Name: (2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl ethyl diisopropylphosphoramidite

InChI: InChI=1S/C46H55N4O9P/c1-9-57-60(50(31(2)3)32(4)5)59-41-39(58-44(42(41)55-8)49-29-28-40(48-45(49)52)47-43(51)33-16-12-10-13-17-33)30-56-46(34-18-14-11-15-19-34,35-20-24-37(53-6)25-21-35)36-22-26-38(54-7)27-23-36/h10-29,31-32,39,41-42,44H,9,30H2,1-8H3,(H,47,48,51,52)/t39-,41-,42-,44-,60?/m1/s1

Synonyms: Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[ethyl bis(1-methylethyl)phosphoramidite]; 5'-O-DMTr-2'-O-Methyl-C(Bz) ethyl phosphoramidite

2'-O-Methyl Guanosine (n-ibu) ethyl phosphoramidite

Description: 2'-O-Methyl Guanosine (n-ibu) ethyl phosphoramidite is utilized in oligonucleotide synthesis. It features a guanosine nucleoside modified with a 2'-O-Methyl group, protected with an isobutyryl (n-ibu) group, and coupled with an ethyl phosphoramidite. It enables controlled and efficient incorporation of modified guanosine into oligonucleotide sequences, crucial for tailored oligonucleotide design in various biological applications.

CAT: BRP-01280

CAS: 179478-99-0

MF: C44H57N6O9P

MF: 844.92

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InChIKey: WSJCHORSJDZQEN-FRQJXJFPSA-N

CanonicalSMILES: O=C1N=C(NC(=O)C(C)C)NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP(OCC)N(C(C)C)C(C)C)C3OC

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl ethyl diisopropylphosphoramidite

InChI: InChI=1S/C44H57N6O9P/c1-11-57-60(50(28(4)5)29(6)7)59-37-35(58-42(38(37)55-10)49-26-45-36-39(49)46-43(48-41(36)52)47-40(51)27(2)3)25-56-44(30-15-13-12-14-16-30,31-17-21-33(53-8)22-18-31)32-19-23-34(54-9)24-20-32/h12-24,26-29,35,37-38,42H,11,25H2,1-10H3,(H2,46,47,48,51,52)/t35-,37-,38-,42-,60?/m1/s1

Synonyms: Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-N-(2-methyl-1-oxopropyl)-, 3'-[ethyl bis(1-methylethyl)phosphoramidite]; 5'-O-DMTr-2'-O-Methyl-G(iBu) ethyl phosphoramidite

2'-O-Methyl Uridine ethyl phosphoramidite

Description: 2'-O-Methyl Uridine ethyl phosphoramidite is used in oligonucleotide synthesis. It comprises a uridine nucleoside modified with a 2'-O-Methyl group and coupled with an ethyl phosphoramidite. It facilitates the precise incorporation of modified uridine into nucleotide chains during solid-phase synthesis, facilitating the design and synthesis of specialized oligonucleotides for use in molecular biology, genetics, diagnostics, and therapeutics.

CAT: BRP-01281

CAS: 179479-00-6

MF: C39H50N3O9P

MF: 735.81

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InChIKey: COIUWZYORZFHID-SGXIJWRWSA-N

CanonicalSMILES: O=C1C=CN(C(=O)N1)C2OC(COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)C(OP(OCC)N(C(C)C)C(C)C)C2OC

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl ethyl diisopropylphosphoramidite

InChI: InChI=1S/C39H50N3O9P/c1-9-49-52(42(26(2)3)27(4)5)51-35-33(50-37(36(35)47-8)41-24-23-34(43)40-38(41)44)25-48-39(28-13-11-10-12-14-28,29-15-19-31(45-6)20-16-29)30-17-21-32(46-7)22-18-30/h10-24,26-27,33,35-37H,9,25H2,1-8H3,(H,40,43,44)/t33-,35-,36-,37-,52?/m1/s1

Synonyms: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[ethyl bis(1-methylethyl)phosphoramidite]; 5'-O-DMTr-2'-O-Methyl-U ethyl phosphoramidite