Phosphoramidites

Description: [5'-O-DMTr-2'-OMe-G(iBu)](pCyEt)[2'-OMe-A(Bz)](pCyEt)[2'-OMe-C(Ac)-3'-CE-Phosphoramidite] is a complex modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of three sequentially linked nucleosides: a 5'-O-DMTr-2'-O-methyl-guanosine (2'-OMe-G) with an isobutyryl (iBu) protecting group, a 2'-O-methyl-adenosine (2'-OMe-A) with a benzoyl (Bz) protecting group, and a 2'-O-methyl-cytidine (2'-OMe-C) with an acetyl (Ac) protecting group. Each linkage is protected by a cyanoethyl (CE) group, ensuring stability during synthesis. These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making them valuable for advanced biochemical research and therapeutic applications.

CAT: BRP-01194

Molecular Formula: C81H96N17O24P3

Molecular Weight: 1784.68

Purity: ≥90% by HPLC

Appearance: White, off-white to faint yellow powder

Description: TFA-Aminobutyl-1-3-propanediol-DMT succinate, TEA salt, is a synthetic intermediate or compound used in organic chemistry and biochemical research. It features a trifluoroacetyl (TFA) group, an aminobutyl-1,3-propanediol moiety, and a dimethoxytrityl (DMT) protection group linked to a succinate modification. This compound is utilized in solid-phase synthesis of molecules and potentially in drug discovery processes where chemical modifications and protection groups are essential for the development and manipulation of organic molecules.

CAT: BRP-01241

Molecular Formula: C34H38F3NO8 (free acid)

Molecular Weight: 645.67 (free acid)

Purity: ≥98% by UPLC

Appearance: Colorless to yellow oily matter

Description: 3-O-DMT-2,2-(dicarboxymethylamido)propyl-1-O-succinate, TEA salt is a chemical compound stabilized with triethylamine (TEA) salt. This compound is likely used in organic synthesis as an intermediate or precursor for the modification of biomolecules or organic compounds, particularly in solid-phase synthesis or other chemical reactions requiring stable protection groups and functional groups for further manipulation.

CAT: BRP-01242

Molecular Formula: C32H36N2O9 (free acid)

Molecular Weight: 592.65 (free acid)

Purity: ≥97% by HPLC

Appearance: White, off-white to light yellow powder

Description: Cholesteryl succinate, TEA salt (plant source), refers to a compound derived from plants that combines cholesteryl (a cholesterol derivative) with succinic acid, forming a salt stabilized with triethylamine (TEA). This compound is utilized in various biochemical and pharmaceutical applications, particularly in lipid research and drug delivery systems. Cholesteryl derivatives are known for their ability to interact with lipid membranes and cellular structures, making them valuable in studies involving liposomes, lipid-based nanoparticles, and drug formulation.

CAT: BRP-01243

Molecular Formula: C61H86O9 (free acid)

Molecular Weight: 963.35 (free acid)

Purity: ≥98% by HPLC

Appearance: Colorless to faint yellow oily matter

Description: 3'-Thio modifier 6 S-S-DMTr-linker-succinate, TEA salt, is a specialized chemical compound used in nucleic acid synthesis and modification. The salt form is stabilized with triethylamine (TEA), enhancing its stability and solubility in aqueous solutions commonly used in biochemical research. This compound is crucial in nucleoside chemistry for introducing modifications at the 3' end of nucleic acids, which can alter their stability, interaction properties, or enzymatic resistance. Such modifications are valuable in studies aiming to understand RNA or DNA structure-function relationships, in nucleic acid-based technologies, and in the development of therapeutic oligonucleotides.

CAT: BRP-01244

Molecular Formula: C35H44O9S2 (free acid)

Molecular Weight: 672.85 (free acid)

Purity: ≥98% by HPLC

Appearance: White, off-white to faint yellow powder

Description: Cholesteryl-TEG-succinate (plant source) is a compound derived from plants that combines cholesteryl (a derivative of cholesterol) with succinic acid, incorporating a tetraethylene glycol (TEG) linker. This structure is designed to enhance the solubility and stability of cholesteryl in aqueous solutions, making it suitable for various applications in biochemical and pharmaceutical research. In biochemical studies, cholesteryl derivatives are utilized to investigate lipid-protein interactions, lipid-based drug delivery systems, and the formation of liposomes. The addition of a TEG linker further improves the compound's solubility and allows for conjugation with other molecules or attachment to surfaces, potentially facilitating its use in drug delivery vehicles or biomaterials.

CAT: BRP-01245

CAS: 873435-28-0

Molecular Formula: C65H93NO13

Molecular Weight: 1096.45

Purity: ≥98% by HPLC

Appearance: Colorless to faint yellow oily matter

Description: 2',3'-Diacetyl Guanosine (n-ibu) CED phosphoramidite is a chemically modified guanosine nucleotide used in oligonucleotide synthesis. Featuring acetyl groups at the 2' and 3' positions and a CED (cyanoethyl diisopropylamino) phosphoramidite group, it facilitates the creation of stable, high-fidelity DNA and RNA sequences for advanced genetic research and biotechnological applications.

CAT: BRP-01255

CAS: 1350450-67-7

Molecular Formula: C27H40N7O9P

Molecular Weight: 637.63

Description: 2',3'-Diacetyl Uridine CED phosphoramidite is a modified uridine nucleotide used in the synthesis of RNA and DNA oligonucleotides. It has acetyl groups at the 2' and 3' positions and a CED (cyanoethyl diisopropylamino) phosphoramidite group, enabling the production of stable and high-fidelity nucleic acid sequences for genetic research and biotechnological applications.

CAT: BRP-01256

CAS: 208655-84-9

Molecular Formula: C22H33N4O9P

Molecular Weight: 528.49

Description: 2'-O-butyne Uridine CED phosphoramidite is a chemical compound used in oligonucleotide synthesis. It is a derivative of uridine, where the 2' position of the ribose sugar is modified with a butyne group (-C≡C-) and is functionalized with a CED (2-cyanoethyl diisopropylphosphoramidite) moiety. This modification allows for the selective incorporation of the modified uridine into the growing nucleotide chain during solid-phase synthesis of oligonucleotides. The presence of the butyne group enables further chemical reactions for the conjugation of various functional groups or molecules. This compound plays a crucial role in the design and synthesis of specialized oligonucleotides for applications in molecular biology, diagnostics, and therapeutics.

CAT: BRP-01258

CAS: 2305570-48-1

Molecular Formula: C43H51N4O9P

Molecular Weight: 798.86

Description: 2'-O-butyne Adenosine (n-bz) CED phosphoramidite is a specialized compound used in oligonucleotide synthesis. It consists of an adenosine nucleoside with a modification at the 2' position of the ribose sugar, where a butyne (-C≡C-) group is attached. Additionally, it features a benzoyl (n-bz) group to protect the amino group at the N6 position of adenine and a CED (2-cyanoethyl diisopropylphosphoramidite) moiety. This modification enables the selective incorporation of the modified adenosine into the growing nucleotide chain during solid-phase synthesis of oligonucleotides. The presence of the butyne group allows for further functionalization or conjugation, making it useful for various applications in molecular biology, diagnostics, and therapeutics.

CAT: BRP-01259

Molecular Formula: C51H56N7O8P

Molecular Weight: 926.01

Description: 2'-O-butyne Guanosine (n-ibu) CED phosphoramidite is a specialized compound utilized in oligonucleotide synthesis. It consists of a guanosine nucleoside with a modification at the 2' position of the ribose sugar, where a butyne (-C≡C-) group is attached. Additionally, it features an isobutyryl (n-ibu) group to protect the amino group at the N2 position of guanine and a CED (2-cyanoethyl diisopropylphosphoramidite) moiety. This modification allows for the selective incorporation of the modified guanosine into the growing nucleotide chain during solid-phase synthesis of oligonucleotides. The presence of the butyne group enables further functionalization or conjugation, making it valuable for various applications in molecular biology, diagnostics, and therapeutics.

CAT: BRP-01260

Molecular Formula: C48H58N7O9P

Molecular Weight: 907.99

Description: 2'-O-butyne Cytidine (n-bz) CED phosphoramidite is a specialized reagent used in oligonucleotide synthesis. It consists of a cytidine nucleoside modified with a 2'-O-butyne group and protected with a benzoyl (n-bz) group. Additionally, it contains a CED (2-cyanoethyl diisopropylphosphoramidite) moiety, which serves as a protecting group during the synthesis process. This phosphoramidite derivative allows for efficient and selective incorporation of the modified cytidine into the growing nucleotide chain during solid-phase synthesis. The presence of the butyne group enables further chemical reactions for the conjugation of various functional groups or molecules. This compound plays a crucial role in the design and synthesis of specialized oligonucleotides for applications in molecular biology, diagnostics, and therapeutics.

CAT: BRP-01265

Molecular Formula: C50H56N5O9P

Molecular Weight: 901.98

Description: 2'-O-Methyl Guanosine (n-PAC) CED phosphoramidite is a specialized reagent used in oligonucleotide synthesis. It consists of a guanosine nucleoside modified with a 2'-O-Methyl group and protected with a PAC (phenoxyacetyl) group. Additionally, it contains a CED (2-cyanoethyl diisopropylphosphoramidite) moiety, which serves as a protecting group during the synthesis process. This phosphoramidite derivative allows for efficient and selective incorporation of the modified guanosine into the growing nucleotide chain during solid-phase synthesis. The presence of the 2'-O-Methyl group provides stability and can influence the properties of the resulting oligonucleotide. This compound is essential in the design and synthesis of modified oligonucleotides for various applications in molecular biology, diagnostics, and therapeutics.

CAT: BRP-01267

CAS: 138906-79-3

Molecular Formula: C49H56N7O10P

Molecular Weight: 933.96

Description: MMT-2'-O-Methyl Adenosine (n-bz) CED phosphoramidite is a specialized reagent used in oligonucleotide synthesis. It consists of an adenosine nucleoside modified with a 2'-O-Methyl group and protected with a benzoyl (n-bz) group. Additionally, it contains a CED (2-cyanoethyl diisopropylphosphoramidite) moiety, which serves as a protecting group during the synthesis process. The MMT (Monomethoxytrityl) group is typically used for temporary protection of hydroxyl groups in nucleosides. This phosphoramidite derivative allows for efficient and selective incorporation of the modified adenosine into the growing nucleotide chain during solid-phase synthesis. This compound is crucial in the design and synthesis of modified oligonucleotides for various applications in molecular biology, diagnostics, and therapeutics.

CAT: BRP-01270

CAS: 2645354-88-5

Molecular Formula: C47H52N7O7P

Molecular Weight: 857.93

Description: MMT-2'-O-Methyl Guanosine (n-ibu) CED phosphoramidite is a specialized reagent employed in oligonucleotide synthesis. It features a guanosine nucleoside with a 2'-O-Methyl modification, protected by an isobutyryl (n-ibu) group, and coupled with a CED (2-cyanoethyl diisopropylphosphoramidite) moiety. The MMT (Monomethoxytrityl) group temporarily shields hydroxyl groups in nucleosides during synthesis. This phosphoramidite enables precise incorporation of the modified guanosine into nucleotide chains during solid-phase synthesis, vital for tailored oligonucleotide design in molecular biology, diagnostics, and therapeutics.

CAT: BRP-01271

CAS: 110782-32-6

Molecular Formula: C44H54N7O8P

Molecular Weight: 839.92

Description: 2'-O-Methyl Cytidine (N-PAC) 3'-O-BMEG phosphoramidite is utilized in oligonucleotide synthesis. It involves a cytidine nucleoside that has been modified with a 2'-O-Methyl group, protected with a PAC group (phenoxyacetyl), and coupled with a 3'-O-BMEG (3'-O-benzyl-2'-O-methyl-2'-O-(2-cyanoethyl) guanosine) phosphoramidite. It facilitates the precise incorporation of modified cytidine into nucleotide chains during solid-phase synthesis, critical for various applications in molecular biology, genetics, diagnostics, and therapeutics.

CAT: BRP-01274

Molecular Formula: C53H67N4O12PS

Molecular Weight: 1015.16

Description: 2'-O-Methyl Guanosine (N-iPrPAC) 3'-O-BMEG phosphoramidite is used in oligonucleotide synthesis. It consists of a guanosine nucleoside modified with a 2'-O-Methyl group, protected with an isopropylphenoxyacetyl (iPr-Pac) group, and coupled with a 3'-O-BMEG phosphoramidite. It enables controlled and efficient incorporation of modified guanosine into oligonucleotide sequences, crucial for tailored oligonucleotide design in various biological applications.

CAT: BRP-01275

Molecular Formula: C57H73N6O12PS

Molecular Weight: 1097.26

Description: 2'-O-Methyl Uridine 3'-O-BMEG phosphoramidite is employed in oligonucleotide synthesis. It features a uridine nucleoside modified with a 2'-O-Methyl group and coupled with a 3'-O-BMEG phosphoramidite. It enables the precise incorporation of modified uridine into nucleotide chains during solid-phase synthesis, facilitating the design and synthesis of specialized oligonucleotides for use in molecular biology, genetics, diagnostics, and therapeutics.

CAT: BRP-01276

CAS: 1219597-71-3

Molecular Formula: C45H60N3O11PS

Molecular Weight: 882.01

Description: 2'-O-Methyl Adenosine (N-PAC) 3'-O-BMEG phosphoramidite is utilized in oligonucleotide synthesis. It comprises an adenosine nucleoside modified with a 2'-O-Methyl group and protected with a PAC group (phenoxyacetyl), coupled with a 3'-O-BMEG (3'-O-benzyl-2'-O-methyl-2'-O-(2-cyanoethyl) guanosine) phosphoramidite. It facilitates precise incorporation of modified adenosine into nucleotide chains during solid-phase synthesis, critical for various applications in molecular biology, genetics, diagnostics, and therapeutics.

CAT: BRP-01277

CAS: 1219597-69-9

Molecular Formula: C54H67N6O11PS

Molecular Weight: 1039.18

Description: 2'-O-Methyl Adenosine (n-bz) ethyl phosphoramidite is used in oligonucleotide synthesis. It involves an adenosine nucleoside modified with a 2'-O-Methyl group and protected with a benzoyl (n-bz) group, coupled with an ethyl phosphoramidite. It enables controlled and efficient incorporation of modified adenosine into oligonucleotide sequences, crucial for tailored oligonucleotide design in various biological applications.

CAT: BRP-01278

CAS: 179478-97-8

Molecular Formula: C47H55N6O8P

Molecular Weight: 862.95