Phosphoramidites

Description: MMT-2'-tBDSilyl Guanosine (n-PAC) CED phosphoramidite is used in oligonucleotide synthesis. It comprises a guanosine nucleoside modified with a 2'-tBDSilyl group and protected with a PAC (phenoxyacetyl) group. Additionally, it contains a CED (2-cyanoethyl diisopropylphosphoramidite) moiety, serving as a protecting group during synthesis. The MMT (Monomethoxytrityl) group temporarily shields hydroxyl groups in nucleosides. This phosphoramidite derivative facilitates efficient and selective incorporation of the modified guanosine into oligonucleotide sequences during solid-phase synthesis, crucial for tailored oligonucleotide design in various biological applications.

CAT: BRP-01322

Molecular Formula: C53H66N7O9PSi

Molecular Weight: 1004.19

Description: MMT-2'-tBDSilyl Adenosine (n-PAC) CED phosphoramidite is utilized in oligonucleotide synthesis. It involves an adenosine nucleoside modified with a 2'-tBDSilyl group and protected with a PAC (phenoxyacetyl) group, coupled with a CED (2-cyanoethyl diisopropylphosphoramidite) moiety. The MMT (Monomethoxytrityl) group is typically used for temporary protection of hydroxyl groups in nucleosides. This phosphoramidite derivative enables efficient and selective incorporation of the modified adenosine into oligonucleotide sequences during solid-phase synthesis, essential for customized oligonucleotide design in various biological applications.

CAT: BRP-01323

Molecular Formula: C53H66N7O8PSi

Molecular Weight: 988.19

Description: N2-Isobutyryl-2'-tert-butyldimethylsilyl-7-deaza-5'-O-DMT-guanosine 3'-CE phosphoramidite is a specialized reagent used in oligonucleotide synthesis. It consists of a guanosine nucleoside modified at the N2 position with an isobutyryl group, at the 2' position with a tert-butyldimethylsilyl group, and at the 5' position with a DMT (dimethoxytrityl) group. Additionally, it contains a CE (2-cyanoethyl) phosphoramidite moiety, which serves as a protecting group during the synthesis process. This phosphoramidite derivative enables the efficient and selective incorporation of the modified guanosine into the growing nucleotide chain during solid-phase synthesis. It is crucial in the design and synthesis of modified oligonucleotides for various applications in molecular biology, genetics, diagnostics, and therapeutics.

CAT: BRP-01326

CAS: 1220889-83-7

Molecular Formula: C51H69N6O9PSi

Molecular Weight: 969.19

Description: 8-Oxo-2'-tBDSilyl Guanosine CED Phosphoramidite is a specialized reagent utilized in oligonucleotide synthesis. It comprises a guanosine nucleoside modified with an 8-oxo group at the 8-position of the purine ring, protected with a TBDMS (tert-butyldimethylsilyl) group at the 2'-position, and with an isobutyryl (n-iBu) group. Additionally, it contains a phosphoramidite moiety with a CE (cyanoethyl) group, serving as a protecting group during synthesis. This phosphoramidite derivative enables precise and efficient incorporation of the modified guanosine into the growing nucleotide chain during solid-phase synthesis. The presence of the 8-oxo modification is significant for investigating oxidative stress, DNA damage, and RNA modification processes.

CAT: BRP-01327

Molecular Formula: C49H67N8O9PSi

Molecular Weight: 971.16

Description: Fmoc-Amino-DMT C-3 CED phosphoramidite is a specialized compound used in oligonucleotide synthesis. It features an Fmoc-protected amino group, a DMT group for 5' hydroxyl protection, and a C-3 spacer linked to a cyanoethyl diisopropyl (CED) phosphoramidite group. This compound enables the controlled addition of amino functionalities to oligonucleotides, facilitating further chemical modifications or conjugations for various research and diagnostic applications.

CAT: BRP-01334

CAS: 146918-92-5

Molecular Formula: C48H54N3O7P

Molecular Weight: 815.93

Description: TFA-Amino C-4 CED phosphoramidite is a specialized compound used in oligonucleotide synthesis. It contains a trifluoroacetyl (TFA)-protected amino group, a C-4 spacer, and a cyanoethyl diisopropyl (CED) phosphoramidite group. This compound facilitates controlled addition of amino functionalities to oligonucleotides, enabling further chemical modifications or conjugations for various research and diagnostic applications.

CAT: BRP-01335

CAS: 936471-68-0

Molecular Formula: C15H27F3N3O3P

Molecular Weight: 385.26

Description: Fmoc-Amino C-6 3'-CE phosphoramidite is a compound used in oligonucleotide synthesis. It features an Fmoc-protected amino group, attached to a C-6 spacer, and a 3'-cyanoethyl (3'-CE) phosphoramidite group. This compound enables the controlled addition of amino functionalities to oligonucleotides, allowing for further chemical modifications or conjugations for various research and diagnostic applications.

CAT: BRP-01336

CAS: 164394-19-8

Molecular Formula: C30H42N3O4P

Molecular Weight: 539.65

Description: Fmoc-Amino-DMT C-7 CE phosphoramidite is a specialized compound utilized in oligonucleotide synthesis. It contains an Fmoc-protected amino group, a DMT group for 5' hydroxyl protection, and a C-7 spacer linked to a cyanoethyl (CE) phosphoramidite group. This compound enables controlled addition of amino functionalities to oligonucleotides, allowing for further chemical modifications or conjugations for various research and diagnostic applications.

CAT: BRP-01337

CAS: 2166602-99-7

Molecular Formula: C51H60N3O8P

Molecular Weight: 874.01

Description: 2,2'-Anhydro Uridine CED phosphoramidite is a specialized reagent used in oligonucleotide synthesis. This modification is attached to a phosphoramidite moiety with a cyanoethyl diisopropyl (CED) group, facilitating its incorporation into the growing oligonucleotide chain during solid-phase synthesis. This reagent enables the introduction of the 2,2'-anhydro uridine modification into synthetic oligonucleotides, allowing for the investigation of its effects on RNA structure and function.

CAT: BRP-01343

Molecular Formula: C39H45N4O8P

Molecular Weight: 728.77

Description: Asymmetrical branching CED phosphoramidite is a chemical used to introduce branches into oligonucleotides during synthesis. It features an asymmetrical structure that enables the formation of complex, branched DNA or RNA sequences. This reagent is utilized in advanced molecular biology applications, such as the creation of multivalent probes, enhanced signal amplification assays, and the study of complex nucleic acid interactions.

CAT: BRP-01349

CAS: 345663-34-5

Molecular Formula: C38H49N2O8P

Molecular Weight: 692.78

Description: 4-Triazolyl Uridine CED phosphoramidite is a phosphoramidite derivative of uridine, featuring a 4-triazolyl modification at the 4-position and a tert-butyldimethylsilyl (TBDMS) protection group at the 2'-position. It is utilized in solid-phase oligonucleotide synthesis to introduce the 4-triazolyl modification, enabling the formation of triazole-linked nucleic acids. These modified nucleic acids can be used in various applications, including click chemistry-based conjugation strategies and the study of nucleic acid structure and function.

CAT: BRP-01356

CAS: 3033741-07-7

Molecular Formula: C47H62N7O8PSi

Molecular Weight: 912.10

Description: Dabcyl CED phosphoramidite is a phosphoramidite derivative used for introducing the Dabcyl moiety into oligonucleotide sequences during solid-phase synthesis. Dabcyl is a quencher molecule often employed in the design of molecular probes and assays, particularly for fluorescence-based detection methods. Its ability to quench fluorescence by energy transfer makes it useful for labeling nucleic acids and peptides for various biochemical and molecular biology applications, including fluorescence resonance energy transfer (FRET) assays, nucleic acid hybridization studies, and real-time PCR probes.

CAT: BRP-01357

CAS: 2128327-84-2

Molecular Formula: C51H63N6O7P

Molecular Weight: 903.06

Description: DMT-5-FAM Phosphoramidite is a phosphoramidite derivative used to incorporate 5-carboxyfluorescein (5-FAM) into oligonucleotides during solid-phase synthesis. It features a 5-FAM fluorophore and a dimethoxytrityl (DMT) protecting group. This reagent allows for the efficient synthesis of fluorescently labeled oligonucleotides, which are widely used in molecular biology applications such as fluorescence-based detection, quantitative PCR (qPCR), and various types of fluorescence resonance energy transfer (FRET) assays.

CAT: BRP-01361

CAS: 1799331-55-7

Molecular Formula: C68H78N3O13P

Molecular Weight: 1176.33

Description: Fluorescein CED phosphoramidite is a phosphoramidite derivative of fluorescein, a fluorescent dye commonly used in molecular biology applications. This reagent is designed to be incorporated into oligonucleotides during solid-phase synthesis, allowing for the specific labeling of nucleic acids with fluorescein. Upon incorporation, the fluorescein moiety enables the detection and visualization of the labeled oligonucleotides using fluorescence-based techniques. This makes it valuable for various applications such as fluorescence in situ hybridization (FISH), fluorescence resonance energy transfer (FRET) assays, and real-time PCR (qPCR) where fluorescent labeling is required for detection and quantification.

CAT: BRP-01362

Molecular Formula: C67H77N4O13PS

Molecular Weight: 1209.39

Description: Tetrachloro-fluorescein cyclohexyl CED phosphoramidite is a phosphoramidite derivative of tetrachloro-fluorescein cyclohexyl, a fluorescent dye. It is designed to be incorporated into oligonucleotides during solid-phase synthesis, enabling the specific labeling of nucleic acids with tetrachloro-fluorescein cyclohexyl. Once incorporated, this label allows for the detection and visualization of the labeled oligonucleotides using fluorescence-based techniques. It is a valuable tool in molecular biology applications such as fluorescence in situ hybridization (FISH), fluorescence resonance energy transfer (FRET) assays, and real-time PCR (qPCR), where specific fluorescent labeling is essential for detection and quantification.

CAT: BRP-01365

Molecular Formula: C69H74Cl4N3O13P

Molecular Weight: 1326.12

Description: Hexachloro-fluorescein cyclohexyl CED phosphoramidite is a phosphoramidite derivative of hexachloro-fluorescein cyclohexyl, a fluorescent dye. It is utilized in oligonucleotide synthesis to introduce hexachloro-fluorescein cyclohexyl labels into nucleic acid sequences. Once incorporated, this label enables the detection and visualization of the labeled oligonucleotides using fluorescence-based techniques. It is a valuable tool in molecular biology applications such as fluorescence in situ hybridization (FISH), fluorescence resonance energy transfer (FRET) assays, and real-time PCR (qPCR), where specific fluorescent labeling is essential for detection and quantification.

CAT: BRP-01366

Molecular Formula: C69H72Cl6N3O13P

Molecular Weight: 1395.01

Description: 8-Bromo Adenosine CED phosphoramidite is a phosphoramidite derivative of 8-bromo adenosine, a modified nucleoside. It is designed to be incorporated into oligonucleotides during solid-phase synthesis, allowing for the specific labeling or modification of nucleic acids with 8-bromo adenosine. Once incorporated, this modification can confer unique properties to the oligonucleotide, such as altered base pairing or increased stability. This reagent is particularly useful in studies where specific chemical modifications of nucleic acids are desired, such as in probing nucleic acid-protein interactions or in the development of therapeutic oligonucleotides.

CAT: BRP-01368

CAS: 197712-21-3

Molecular Formula: C55H78BrN8O7PSi

Molecular Weight: 1102.22

Description: 5-Bromo 2'-TBDMS C(Bz) 3'-CE phosphoramidite is used in oligonucleotide synthesis to introduce 5-bromo modifications. It provides enhanced stability and specific chemical properties for research and therapeutic applications.

CAT: BRP-01374

Molecular Formula: C52H65BrN5O9PSi

Molecular Weight: 1043.06

Description: IsoCytidine CED phosphoramidite serves as a specialized reagent in oligonucleotide synthesis, facilitating the incorporation of IsoCytidine with specific modifications into nucleic acid sequences. This reagent enables the customization of oligonucleotide sequences with IsoCytidine modifications, providing researchers with tailored tools for various applications in molecular biology, including nucleic acid labeling, structural studies, and therapeutic development.

CAT: BRP-01376

Molecular Formula: C54H79N6O8PSi

Molecular Weight: 999.32

Description: isoGuanosine CED phosphoramidite facilitates the incorporation of modified guanosine, isoGuanosine, into oligonucleotides during synthesis, providing tailored chemical properties for diverse research and therapeutic applications.

CAT: BRP-01378

Molecular Formula: C55H79N8O8PSi

Molecular Weight: 1039.34