Phosphoramidites - RNA / BOC Sciences

Asymmetrical branching CED phosphoramidite

Description: Asymmetrical branching CED phosphoramidite is a chemical used to introduce branches into oligonucleotides during synthesis. It features an asymmetrical structure that enables the formation of complex, branched DNA or RNA sequences. This reagent is utilized in advanced molecular biology applications, such as the creation of multivalent probes, enhanced signal amplification assays, and the study of complex nucleic acid interactions.

CAT: BRP-01349

CAS: 345663-34-5

MF: C38H49N2O8P

MF: 692.78

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InChIKey: HYEDNLHCXFQSQY-UHFFFAOYSA-N

CanonicalSMILES: N#CCCOP(OC(COC(=O)CCC(=O)C)COC(C=1C=CC=CC1)(C2=CC=C(OC)C=C2)C3=CC=C(OC)C=C3)N(C(C)C)C(C)C

IUPAC Name: 3-(bis(4-methoxyphenyl)(phenyl)methoxy)-2-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)propyl 4-oxopentanoate

InChI: InChI=1S/C38H49N2O8P/c1-28(2)40(29(3)4)49(47-25-11-24-39)48-36(26-45-37(42)23-14-30(5)41)27-46-38(31-12-9-8-10-13-31,32-15-19-34(43-6)20-16-32)33-17-21-35(44-7)22-18-33/h8-10,12-13,15-22,28-29,36H,11,14,23,25-27H2,1-7H3

Synonyms: Pentanoic acid, 4-oxo-, 3-[bis(4-methoxyphenyl)phenylmethoxy]-2-[[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]oxy]propyl ester; 3-[Bis(4-methoxyphenyl)phenylmethoxy]-2-[[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]oxy]propyl 4-oxopentanoate

4-Triazolyl 2'-TBDMS Uridine CED phosphoramidite

Description: 4-Triazolyl Uridine CED phosphoramidite is a phosphoramidite derivative of uridine, featuring a 4-triazolyl modification at the 4-position and a tert-butyldimethylsilyl (TBDMS) protection group at the 2'-position. It is utilized in solid-phase oligonucleotide synthesis to introduce the 4-triazolyl modification, enabling the formation of triazole-linked nucleic acids. These modified nucleic acids can be used in various applications, including click chemistry-based conjugation strategies and the study of nucleic acid structure and function.

CAT: BRP-01356

CAS: 3033741-07-7

MF: C47H62N7O8PSi

MF: 912.10

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InChIKey: SDOHATSBOOYVAE-HEOXLOLOSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=CC(=NC2=O)N3N=CN=C3)C1O[Si](C)(C)C(C)(C)C)COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2-oxo-4-(1H-1,2,4-triazol-1-yl)pyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C47H62N7O8PSi/c1-33(2)54(34(3)4)63(59-29-15-27-48)61-42-40(60-44(43(42)62-64(10,11)46(5,6)7)52-28-26-41(51-45(52)55)53-32-49-31-50-53)30-58-47(35-16-13-12-14-17-35,36-18-22-38(56-8)23-19-36)37-20-24-39(57-9)25-21-37/h12-14,16-26,28,31-34,40,42-44H,15,29-30H2,1-11H3/t40-,42-,43-,44-,63?/m1/s1

Synonyms: 2(1H)-Pyrimidinone, 1-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-O-[(1,1-dimethylethyl)dimethylsilyl]-β-D-ribofuranosyl]-4-(1H-1,2,4-triazol-1-yl)-; 4-Triazolyl Uridine CED phosphoramidite

Dabcyl CED phosphoramidite

Description: Dabcyl CED phosphoramidite is a phosphoramidite derivative used for introducing the Dabcyl moiety into oligonucleotide sequences during solid-phase synthesis. Dabcyl is a quencher molecule often employed in the design of molecular probes and assays, particularly for fluorescence-based detection methods. Its ability to quench fluorescence by energy transfer makes it useful for labeling nucleic acids and peptides for various biochemical and molecular biology applications, including fluorescence resonance energy transfer (FRET) assays, nucleic acid hybridization studies, and real-time PCR probes.

CAT: BRP-01357

CAS: 2128327-84-2

MF: C51H63N6O7P

MF: 903.06

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InChIKey: CFNGUZAXHBVWBU-UHFFFAOYSA-N

CanonicalSMILES: N#CCCOP(OC(COCCCNC(=O)C1=CC=C(N=NC2=CC=C(C=C2)N(C)C)C=C1)COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)N(C(C)C)C(C)C

IUPAC Name: 1-(bis(4-methoxyphenyl)(phenyl)methoxy)-3-(3-(4-((4-(dimethylamino)phenyl)diazenyl)benzamido)propoxy)propan-2-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C51H63N6O7P/c1-38(2)57(39(3)4)65(63-35-12-32-52)64-49(36-61-34-13-33-53-50(58)40-16-22-44(23-17-40)54-55-45-24-26-46(27-25-45)56(5)6)37-62-51(41-14-10-9-11-15-41,42-18-28-47(59-7)29-19-42)43-20-30-48(60-8)31-21-43/h9-11,14-31,38-39,49H,12-13,33-37H2,1-8H3,(H,53,58)

DMT-5-FAM Phosphoramidite

Description: DMT-5-FAM Phosphoramidite is a phosphoramidite derivative used to incorporate 5-carboxyfluorescein (5-FAM) into oligonucleotides during solid-phase synthesis. It features a 5-FAM fluorophore and a dimethoxytrityl (DMT) protecting group. This reagent allows for the efficient synthesis of fluorescently labeled oligonucleotides, which are widely used in molecular biology applications such as fluorescence-based detection, quantitative PCR (qPCR), and various types of fluorescence resonance energy transfer (FRET) assays.

CAT: BRP-01361

CAS: 1799331-55-7

MF: C68H78N3O13P

MF: 1176.33

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InChIKey: SAAQCYSLOUHYEE-UHFFFAOYSA-N

CanonicalSMILES: N#CCCOP(OCC(COC(C=1C=CC=CC1)(C2=CC=C(OC)C=C2)C3=CC=C(OC)C=C3)CCCCNC(=O)C4=CC=C5C(=C4)C(=O)OC65C7=CC=C(OC(=O)C(C)(C)C)C=C7OC8=CC(OC(=O)C(C)(C)C)=CC=C86)N(C(C)C)C(C)C

IUPAC Name: 5-((6-(bis(4-methoxyphenyl)(phenyl)methoxy)-5-((((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)methyl)hexyl)carbamoyl)-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-diyl bis(2,2-dimethylpropanoate)

InChI: InChI=1S/C68H78N3O13P/c1-44(2)71(45(3)4)85(79-38-18-36-69)80-43-46(42-78-67(48-20-14-13-15-21-48,49-23-27-51(76-11)28-24-49)50-25-29-52(77-12)30-26-50)19-16-17-37-70-61(72)47-22-33-56-55(39-47)62(73)84-68(56)57-34-31-53(81-63(74)65(5,6)7)40-59(57)83-60-41-54(32-35-58(60)68)82-64(75)66(8,9)10/h13-15,20-35,39-41,44-46H,16-19,37-38,42-43H2,1-12H3,(H,70,72)

Synonyms: Propanoic acid, 2,2-dimethyl-, 1,1'-[5-[7-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-10-[bis(1-methylethyl)amino]-13-cyano-1-oxo-9,11-dioxa-2-aza-10-phosphatridec-1-yl]-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3',6'-diyl] ester; 1,1'-[5-[7-[[Bis(4-methoxyphenyl)phenylmethoxy]methyl]-10-[bis(1-methylethyl)amino]-13-cyano-1-oxo-9,11-dioxa-2-aza-10-phosphatridec-1-yl]-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3',6'-diyl] bis(2,2-dimethylpropanoate)

Fluorescein CED phosphoramidite

Description: Fluorescein CED phosphoramidite is a phosphoramidite derivative of fluorescein, a fluorescent dye commonly used in molecular biology applications. This reagent is designed to be incorporated into oligonucleotides during solid-phase synthesis, allowing for the specific labeling of nucleic acids with fluorescein. Upon incorporation, the fluorescein moiety enables the detection and visualization of the labeled oligonucleotides using fluorescence-based techniques. This makes it valuable for various applications such as fluorescence in situ hybridization (FISH), fluorescence resonance energy transfer (FRET) assays, and real-time PCR (qPCR) where fluorescent labeling is required for detection and quantification.

CAT: BRP-01362

MF: C67H77N4O13PS

MF: 1209.39

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InChIKey: BZPUELAJXMHPLN-UHFFFAOYSA-N

CanonicalSMILES: N#CCCOP(N(C(C)C)C(C)C)OC(COC(C1=CC=CC=C1)(C2=CC=C(OC)C=C2)C3=CC=C(OC)C=C3)COCCCNC(NC4=CC=C(C56C(C=C7)=C(OC8=C5C=CC(OC(C(C)(C)C)=O)=C8)C=C7OC(C(C)(C)C)=O)C(C(O6)=O)=C4)=S

IUPAC Name: 5-(3-(3-(3-(bis(4-methoxyphenyl)(phenyl)methoxy)-2-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)propoxy)propyl)thioureido)-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-diyl bis(2,2-dimethylpropanoate)

InChI: InChI=1S/C67H77N4O13PS/c1-43(2)71(44(3)4)85(79-37-16-34-68)84-53(42-78-66(45-18-14-13-15-19-45,46-20-25-49(75-11)26-21-46)47-22-27-50(76-12)28-23-47)41-77-36-17-35-69-63(86)70-48-24-31-55-54(38-48)60(72)83-67(55)56-32-29-51(80-61(73)64(5,6)7)39-58(56)82-59-40-52(30-33-57(59)67)81-62(74)65(8,9)10/h13-15,18-33,38-40,43-44,53H,16-17,35-37,41-42H2,1-12H3,(H2,69,70,86)

Tetrachloro-fluorescein cyclohexyl CED phosphoramidite

Description: Tetrachloro-fluorescein cyclohexyl CED phosphoramidite is a phosphoramidite derivative of tetrachloro-fluorescein cyclohexyl, a fluorescent dye. It is designed to be incorporated into oligonucleotides during solid-phase synthesis, enabling the specific labeling of nucleic acids with tetrachloro-fluorescein cyclohexyl. Once incorporated, this label allows for the detection and visualization of the labeled oligonucleotides using fluorescence-based techniques. It is a valuable tool in molecular biology applications such as fluorescence in situ hybridization (FISH), fluorescence resonance energy transfer (FRET) assays, and real-time PCR (qPCR), where specific fluorescent labeling is essential for detection and quantification.

CAT: BRP-01365

MF: C69H74Cl4N3O13P

MF: 1326.12

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InChIKey: SYZVSEPABCJTBW-UHFFFAOYSA-N

CanonicalSMILES: ClC1=CC2=C(C=C1OC(C(C)(C)C)=O)OC3=C(C=C(C(OC(C(C)(C)C)=O)=C3)Cl)C24C5=C(C(C(NC6CCC(COP(N(C(C)C)C(C)C)OCCC#N)(COC(C7=CC=CC=C7)(C8=CC=C(OC)C=C8)C9=CC=C(OC)C=C9)CC6)=O)=CC(Cl)=C5C(O4)=O)Cl

IUPAC Name: 6-((4-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)methyl)cyclohexyl)carbamoyl)-2',4,7,7'-tetrachloro-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-diyl bis(2,2-dimethylpropanoate)

InChI: InChI=1S/C69H74Cl4N3O13P/c1-40(2)76(41(3)4)90(84-32-16-31-74)85-39-67(38-83-68(42-17-14-13-15-18-42,43-19-23-46(81-11)24-20-43)44-21-25-47(82-12)26-22-44)29-27-45(28-30-67)75-61(77)48-33-53(72)58-59(60(48)73)69(89-62(58)78)49-34-51(70)56(87-63(79)65(5,6)7)36-54(49)86-55-37-57(52(71)35-50(55)69)88-64(80)66(8,9)10/h13-15,17-26,33-37,40-41,45H,16,27-30,32,38-39H2,1-12H3,(H,75,77)

Synonyms: Propanoic acid, 2,2-dimethyl-, 6-[[[4-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-4-[[[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]oxy]methyl]cyclohexyl]amino]carbonyl]-2',4,7,7'-tetrachloro-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3',6'-diyl ester

Hexachloro-fluorescein cyclohexyl CED phosphoramidite

Description: Hexachloro-fluorescein cyclohexyl CED phosphoramidite is a phosphoramidite derivative of hexachloro-fluorescein cyclohexyl, a fluorescent dye. It is utilized in oligonucleotide synthesis to introduce hexachloro-fluorescein cyclohexyl labels into nucleic acid sequences. Once incorporated, this label enables the detection and visualization of the labeled oligonucleotides using fluorescence-based techniques. It is a valuable tool in molecular biology applications such as fluorescence in situ hybridization (FISH), fluorescence resonance energy transfer (FRET) assays, and real-time PCR (qPCR), where specific fluorescent labeling is essential for detection and quantification.

CAT: BRP-01366

MF: C69H72Cl6N3O13P

MF: 1395.01

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InChIKey: OXVDGSOEMHTDJI-UHFFFAOYSA-N

CanonicalSMILES: N#CCCOP(OCC1(COC(C=2C=CC=CC2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)CCC(NC(=O)C5=CC(Cl)=C6C(=O)OC7(C8=CC(Cl)=C(OC(=O)C(C)(C)C)C(Cl)=C8OC9=C(Cl)C(OC(=O)C(C)(C)C)=C(Cl)C=C97)C6=C5Cl)CC1)N(C(C)C)C(C)C

IUPAC Name: 6-((4-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)methyl)cyclohexyl)carbamoyl)-2',4,4',5',7,7'-hexachloro-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-diyl bis(2,2-dimethylpropanoate)

InChI: InChI=1S/C69H72Cl6N3O13P/c1-38(2)78(39(3)4)92(86-32-16-31-76)87-37-67(36-85-68(40-17-14-13-15-18-40,41-19-23-44(83-11)24-20-41)42-21-25-45(84-12)26-22-42)29-27-43(28-30-67)77-61(79)46-33-49(70)52-53(54(46)73)69(91-62(52)80)47-34-50(71)59(89-63(81)65(5,6)7)55(74)57(47)88-58-48(69)35-51(72)60(56(58)75)90-64(82)66(8,9)10/h13-15,17-26,33-35,38-39,43H,16,27-30,32,36-37H2,1-12H3,(H,77,79)

Synonyms: Propanoic acid, 2,2-dimethyl-, 6-[[[4-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-4-[[[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]oxy]methyl]cyclohexyl]amino]carbonyl]-2',4,4',5',7,7'-hexachloro-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3',6'-diyl ester

8-Bromo Adenosine (N,N-dibuf) 2'-TBDMS 3'-CE phosphoramidite

Description: 8-Bromo Adenosine CED phosphoramidite is a phosphoramidite derivative of 8-bromo adenosine, a modified nucleoside. It is designed to be incorporated into oligonucleotides during solid-phase synthesis, allowing for the specific labeling or modification of nucleic acids with 8-bromo adenosine. Once incorporated, this modification can confer unique properties to the oligonucleotide, such as altered base pairing or increased stability. This reagent is particularly useful in studies where specific chemical modifications of nucleic acids are desired, such as in probing nucleic acid-protein interactions or in the development of therapeutic oligonucleotides.

CAT: BRP-01368

CAS: 197712-21-3

MF: C55H78BrN8O7PSi

MF: 1102.22

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InChIKey: FNQJWXTZWOYBNH-YYONJIEZSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C(Br)=NC=3C(=NC=NC32)N=CN(CCCC)CCCC)C1O[Si](C)(C)C(C)(C)C)COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(8-bromo-6-(((dibutylamino)methylene)amino)-9H-purin-9-yl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C55H78BrN8O7PSi/c1-14-16-33-62(34-17-15-2)38-60-50-47-51(59-37-58-50)63(53(56)61-47)52-49(71-73(12,13)54(7,8)9)48(70-72(68-35-21-32-57)64(39(3)4)40(5)6)46(69-52)36-67-55(41-22-19-18-20-23-41,42-24-28-44(65-10)29-25-42)43-26-30-45(66-11)31-27-43/h18-20,22-31,37-40,46,48-49,52H,14-17,21,33-36H2,1-13H3/t46-,48-,49-,52-,72?/m1/s1

Synonyms: Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-8-bromo-N-[(dibutylamino)methylene]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; 8-Bromo Adenosine (n,n-dibuf) 2'-TBDMS 3'-CE phosphoramidite; 8-Bromo Adenosine CED phosphoramidite

5-Bromo 2'-TBDMS C(Bz) 3'-CE phosphoramidite

Description: 5-Bromo 2'-TBDMS C(Bz) 3'-CE phosphoramidite is used in oligonucleotide synthesis to introduce 5-bromo modifications. It provides enhanced stability and specific chemical properties for research and therapeutic applications.

CAT: BRP-01374

MF: C52H65BrN5O9PSi

MF: 1043.06

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InChIKey: YKFYFKUKNUWEDK-ZQRHXHOESA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=C(C(=NC2=O)NC(=O)C3=CC=CC=C3)Br)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: (2R,3R,4R,5R)-5-(4-benzamido-5-bromo-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C52H65BrN5O9PSi/c1-35(2)58(36(3)4)68(64-32-18-31-54)66-45-44(34-63-52(38-21-16-13-17-22-38,39-23-27-41(61-8)28-24-39)40-25-29-42(62-9)30-26-40)65-49(46(45)67-69(10,11)51(5,6)7)57-33-43(53)47(56-50(57)60)55-48(59)37-19-14-12-15-20-37/h12-17,19-30,33,35-36,44-46,49H,18,32,34H2,1-11H3,(H,55,56,59,60)/t44-,45-,46-,49-,68?/m1/s1

Synonyms: 2'-OTBS 5-Br-C(Bz) amidite; 5-Bromo Cytidine CED phosphoramidite

2'-TBDMS IsoCytidine (n,n-diisobutylformamidine) 3'-CE phosphoramidite

Description: IsoCytidine CED phosphoramidite serves as a specialized reagent in oligonucleotide synthesis, facilitating the incorporation of IsoCytidine with specific modifications into nucleic acid sequences. This reagent enables the customization of oligonucleotide sequences with IsoCytidine modifications, providing researchers with tailored tools for various applications in molecular biology, including nucleic acid labeling, structural studies, and therapeutic development.

CAT: BRP-01376

MF: C54H79N6O8PSi

MF: 999.32

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InChIKey: VYCGEVNFMOLIFQ-LZONKIJTSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2-(((dibutylamino)methylene)amino)-4-oxopyrimidin-1(4H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C54H79N6O8PSi/c1-14-16-34-58(35-17-15-2)39-56-52-57-48(61)32-36-59(52)51-50(68-70(12,13)53(7,8)9)49(67-69(65-37-21-33-55)60(40(3)4)41(5)6)47(66-51)38-64-54(42-22-19-18-20-23-42,43-24-28-45(62-10)29-25-43)44-26-30-46(63-11)31-27-44/h18-20,22-32,36,39-41,47,49-51H,14-17,21,34-35,37-38H2,1-13H3/t47-,49-,50-,51-,69?/m1/s1

Synonyms: IsoCytidine CED phosphoramidite

2'-TBDMS isoGuanosine (n,n-diisobutylformamidine) 3'-CE phosphoramidite

Description: isoGuanosine CED phosphoramidite facilitates the incorporation of modified guanosine, isoGuanosine, into oligonucleotides during synthesis, providing tailored chemical properties for diverse research and therapeutic applications.

CAT: BRP-01378

MF: C55H79N8O8PSi

MF: 1039.34

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InChIKey: SKPFXYRRDSQWDO-YYONJIEZSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(6-(((dibutylamino)methylene)amino)-2-oxo-2,3-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C55H79N8O8PSi/c1-14-16-33-61(34-17-15-2)37-58-50-47-51(60-53(64)59-50)62(38-57-47)52-49(71-73(12,13)54(7,8)9)48(70-72(68-35-21-32-56)63(39(3)4)40(5)6)46(69-52)36-67-55(41-22-19-18-20-23-41,42-24-28-44(65-10)29-25-42)43-26-30-45(66-11)31-27-43/h18-20,22-31,37-40,46,48-49,52H,14-17,21,33-36H2,1-13H3,(H,59,60,64)/t46-,48-,49-,52-,72?/m1/s1

Synonyms: isoGuanosine CED OP; isoGuanosine CED phosphoramidite

Beta-L-2'-tBDSilyl Cytidine (n-bz) 3'-CED phosphoramidite

Description: Beta-L-2'-tBDSilyl Cytidine (n-bz) 3'-CED phosphoramidite is a specialized reagent used in oligonucleotide synthesis. It incorporates modified cytidine into nucleic acid sequences with a beta-L configuration at the 2'-position of the ribose sugar, a benzoyl protecting group (n-bz) on the cytidine base, and a cyanoethyl (CED) protecting group at the 3'-position. This reagent facilitates precise and controlled synthesis of oligonucleotides for various research and therapeutic applications in molecular biology.

CAT: BRP-01382

MF: C52H66N5O9PSi

MF: 964.17

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InChIKey: VWNXEDLLHIFAOL-KEDRMCAUSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=CC(=NC2=O)NC(=O)C=3C=CC=CC3)C1O[Si](C)(C)C(C)(C)C)COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C

IUPAC Name: (2S,3S,4S,5S)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C52H66N5O9PSi/c1-36(2)57(37(3)4)67(63-34-18-32-53)65-46-44(35-62-52(39-21-16-13-17-22-39,40-23-27-42(60-8)28-24-40)41-25-29-43(61-9)30-26-41)64-49(47(46)66-68(10,11)51(5,6)7)56-33-31-45(55-50(56)59)54-48(58)38-19-14-12-15-20-38/h12-17,19-31,33,36-37,44,46-47,49H,18,34-35H2,1-11H3,(H,54,55,58,59)/t44-,46-,47-,49-,67?/m0/s1

Synonyms: Beta-L-2'-TBDMS C(Bz) 3'-CE phosphoramidite; β-L-Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-tert-butyldimethylsilyl)-β-L-cytidine 3'-O-[O-(2-cyanoethyl)-N,N'-diisopropylphosphoramidite]

5-Iodo Uridine 2'-O-Methyl CED phosphoramidite

Description: 5-Iodo Uridine 2'-O-Methyl CED phosphoramidite is a specialized reagent used in oligonucleotide synthesis to introduce a modified form of uridine into nucleic acid sequences. This modification includes an iodine atom at the 5-position of the uracil base and an O-methyl group at the 2'-position of the ribose sugar. Additionally, it features a cyanoethyl (CED) protecting group, facilitating its incorporation into oligonucleotides during solid-phase synthesis. This reagent allows for the synthesis of oligonucleotides with specific chemical modifications, suitable for various research and diagnostic applications in molecular biology and biotechnology.

CAT: BRP-01386

CAS: 2382941-85-5

MF: C40H48IN4O9P

MF: 886.71

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InChIKey: HKRBVLVOTKMIQV-NITXCQAWSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OC)N2C=C(C(=O)NC2=O)I)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(5-iodo-2,4-dioxopyrimidin-1-yl)-4-methoxyoxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C40H48IN4O9P/c1-26(2)45(27(3)4)55(52-23-11-22-42)54-35-34(53-38(36(35)50-7)44-24-33(41)37(46)43-39(44)47)25-51-40(28-12-9-8-10-13-28,29-14-18-31(48-5)19-15-29)30-16-20-32(49-6)21-17-30/h8-10,12-21,24,26-27,34-36,38H,11,23,25H2,1-7H3,(H,43,46,47)/t34-,35-,36-,38-,55?/m1/s1

Synonyms: 5'-O-DMTr-2'-O-methyl-5-iodouridine-3'-CEN-phosphoramidite; 2'-O-Me-5-I-U-3'-phosphoramidite; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-5-iodo-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

Amino Modifier 2'-O-Methyl C(dmf) 3'-CE phosphoramidite

Description: Amino Modifier 2'-O-Methyl Cytidine CED phosphoramidite is a specialized reagent used in oligonucleotide synthesis to introduce a modification at the 2'-position of the ribose sugar of cytidine. Additionally, it features a dimethylformamide (DMF) protecting group on the amino modification and a cyanoethyl (CE) protecting group at the 3'-position, facilitating its incorporation into oligonucleotides during solid-phase synthesis. This reagent allows for the synthesis of oligonucleotides with specific chemical modifications, suitable for various research and diagnostic applications in molecular biology and biotechnology.

CAT: BRP-01387

MF: C54H70F3N8O10P

MF: 1079.17

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InChIKey: VSEXZAHMBUUFKH-GRFNBCEFSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(4-(((dimethylamino)methylene)amino)-2-oxo-5-((E)-3-oxo-3-((6-(2,2,2-trifluoroacetamido)hexyl)amino)prop-1-en-1-yl)pyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C54H70F3N8O10P/c1-37(2)65(38(3)4)76(73-33-17-30-58)75-47-45(35-72-53(40-18-13-12-14-19-40,41-21-25-43(69-7)26-22-41)42-23-27-44(70-8)28-24-42)74-50(48(47)71-9)64-34-39(49(62-52(64)68)61-36-63(5)6)20-29-46(66)59-31-15-10-11-16-32-60-51(67)54(55,56)57/h12-14,18-29,34,36-38,45,47-48,50H,10-11,15-17,31-33,35H2,1-9H3,(H,59,66)(H,60,67)/b29-20+,61-36?/t45-,47-,48-,50-,76?/m1/s1

Synonyms: Amino Modifier 2'-O-Methyl Cytidine CED phosphoramidite

5-Propynyl-2'-O-Methyl Cytidine CED phosphoramidite

Description: 5-Propynyl-2'-O-Methyl Cytidine CED phosphoramidite is a specialized reagent used in oligonucleotide synthesis to introduce a modified form of cytidine into nucleic acid sequences. This modification involves adding a propynyl group at the 5-position and a benzoyl (Bz) protecting group at the nucleobase of the cytidine nucleoside. Additionally, it features a cyanoethyl (CE) protecting group at the 3'-position, facilitating its incorporation into oligonucleotides during solid-phase synthesis. This reagent enables the synthesis of oligonucleotides with specific chemical modifications, suitable for various research and diagnostic applications in molecular biology and biotechnology.

CAT: BRP-01388

MF: C50H56N5O9P

MF: 901.98

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InChIKey: NCBCXPSFMVIXKS-BRQQSDFOSA-N

IUPAC Name: (2R,3R,4R,5R)-5-(4-benzamido-2-oxo-5-(prop-1-yn-1-yl)pyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C50H56N5O9P/c1-9-17-37-32-54(49(57)53-46(37)52-47(56)36-18-12-10-13-19-36)48-45(60-8)44(64-65(62-31-16-30-51)55(34(2)3)35(4)5)43(63-48)33-61-50(38-20-14-11-15-21-38,39-22-26-41(58-6)27-23-39)40-24-28-42(59-7)29-25-40/h10-15,18-29,32,34-35,43-45,48H,16,31,33H2,1-8H3,(H,52,53,56,57)/t43-,44-,45-,48-,65?/m1/s1

Synonyms: 5-Propynyl-2'-O-Me C(Bz) 3'-CE phosphoramidite; Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-5-(1-propynyl)-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

7-Iodo 7-deaza 2'-O-Methyl Adenosine CED phosphoramidite

Description: 7-Iodo 7-deaza 2'-O-Methyl Adenosine CED phosphoramidite is a specialized reagent used in oligonucleotide synthesis to introduce a modified form of adenosine into nucleic acid sequences. This modification includes replacing the nitrogen atom at the 7-position of the purine ring with an iodine atom, creating a 7-iodo 7-deaza adenosine. Additionally, it features an O-methyl group at the 2'-position of the ribose sugar and a benzoyl (Bz) protecting group at the nucleobase. Furthermore, it includes a cyanoethyl (CE) protecting group at the 3'-position, facilitating its incorporation into oligonucleotides during solid-phase synthesis. This reagent enables the synthesis of oligonucleotides with specific chemical modifications, suitable for various research and diagnostic applications in molecular biology and biotechnology.

CAT: BRP-01389

MF: C49H54IN6O8P

MF: 1012.87

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InChIKey: QZLOROSWVDZRAP-FVPMUMJWSA-N

IUPAC Name: (2R,3R,4R,5R)-5-(4-benzamido-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C49H54IN6O8P/c1-32(2)56(33(3)4)65(62-28-14-27-51)64-43-41(30-61-49(35-17-12-9-13-18-35,36-19-23-38(58-5)24-20-36)37-21-25-39(59-6)26-22-37)63-48(44(43)60-7)55-29-40(50)42-45(52-31-53-46(42)55)54-47(57)34-15-10-8-11-16-34/h8-13,15-26,29,31-33,41,43-44,48H,14,28,30H2,1-7H3,(H,52,53,54,57)/t41-,43-,44-,48-,65?/m1/s1

Synonyms: 7-Iodo 7-deaza 2'-O-Methyl A(Bz) 3'-CE phosphoramidite

7-Iodo 7-deaza 2'-O-Methyl Guanosine CED phosphoramidite

Description: 7-Iodo 7-deaza 2'-O-Methyl Guanosine CED phosphoramidite is a specialized reagent employed in oligonucleotide synthesis for introducing a modified form of guanosine into nucleic acid sequences. It incorporates a 7-iodo modification on the guanine base, a 7-deaza modification to replace the nitrogen atom at the 7-position of the purine ring, an O-methyl group at the 2'-position of the ribose sugar, an isobutyryl protecting group on the guanosine base, and a cyanoethyl protecting group at the 3'-position. This reagent facilitates the controlled synthesis of oligonucleotides with specific chemical modifications, suitable for various research and diagnostic applications in molecular biology and biotechnology.

CAT: BRP-01390

MF: C46H56IN6O9P

MF: 994.85

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InChIKey: ZNNTYQTTYBNQGY-NOYBBXANSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(5-iodo-2-isobutyramido-4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C46H56IN6O9P/c1-28(2)42(54)50-45-49-41-38(43(55)51-45)36(47)26-52(41)44-40(58-9)39(62-63(60-25-13-24-48)53(29(3)4)30(5)6)37(61-44)27-59-46(31-14-11-10-12-15-31,32-16-20-34(56-7)21-17-32)33-18-22-35(57-8)23-19-33/h10-12,14-23,26,28-30,37,39-40,44H,13,25,27H2,1-9H3,(H2,49,50,51,54,55)/t37-,39-,40-,44-,63?/m1/s1

Synonyms: 7-Iodo 7-deaza 2'-O-Methyl G(iBu) 3'-CE phosphoramidite

7-deaza 7-propargyl 2'-O-Methyl Adenosine CED phosphoramidite

Description: 7-deaza 7-propargyl 2'-O-Methyl Adenosine CED phosphoramidite is a specialized reagent used in oligonucleotide synthesis to introduce a modified form of adenosine into nucleic acid sequences. This modification includes replacing the nitrogen atom at the 7-position of the purine ring with a carbon atom linked to a propargyl group, creating a 7-deaza 7-propargyl adenosine. Additionally, it features an O-methyl group at the 2'-position of the ribose sugar and a benzoyl (Bz) protecting group at the nucleobase. Furthermore, it includes a cyanoethyl (CE) protecting group at the 3'-position, facilitating its incorporation into oligonucleotides during solid-phase synthesis. This reagent enables the synthesis of oligonucleotides with specific chemical modifications, suitable for various research and diagnostic applications in molecular biology and biotechnology.

CAT: BRP-01391

MF: C54H57F3N7O9P

MF: 1036.04

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InChIKey: MWDGGUITMWBQOX-QLWGAVRDSA-N

IUPAC Name: (2R,3R,4R,5R)-5-(4-benzamido-5-(3-(2,2,2-trifluoroacetamido)prop-1-yn-1-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C54H57F3N7O9P/c1-35(2)64(36(3)4)74(71-31-15-29-58)73-46-44(33-70-53(39-19-12-9-13-20-39,40-21-25-42(67-5)26-22-40)41-23-27-43(68-6)28-24-41)72-51(47(46)69-7)63-32-38(18-14-30-59-52(66)54(55,56)57)45-48(60-34-61-49(45)63)62-50(65)37-16-10-8-11-17-37/h8-13,16-17,19-28,32,34-36,44,46-47,51H,15,30-31,33H2,1-7H3,(H,59,66)(H,60,61,62,65)/t44-,46-,47-,51-,74?/m1/s1

Synonyms: 7-deaza 7-propargyl 2'-O-Methyl A(Bz) 3'-CE phosphoramidite

7-deaza 7-propargyl 2'-O-Methyl Guanosine CED phosphoramidite

Description: 7-deaza 7-propargyl 2'-O-Methyl Guanosine CED phosphoramidite is a specialized reagent used in oligonucleotide synthesis to modify guanosine. It incorporates a propargyl group at the 7-position and an O-methyl group at the 2'-position of the ribose sugar, with an isobutyryl protecting group on the guanosine base and a cyanoethyl protecting group at the 3'-position, facilitating its integration into oligonucleotides during synthesis.

CAT: BRP-01392

MF: C51H59F3N7O10P

MF: 1018.02

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InChIKey: SZPSULVVPSSTMY-KBAKYSIRSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-4-oxo-5-(3-(2,2,2-trifluoroacetamido)prop-1-yn-1-yl)-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C51H59F3N7O10P/c1-31(2)45(62)58-49-57-44-41(46(63)59-49)34(15-13-27-56-48(64)51(52,53)54)29-60(44)47-43(67-9)42(71-72(69-28-14-26-55)61(32(3)4)33(5)6)40(70-47)30-68-50(35-16-11-10-12-17-35,36-18-22-38(65-7)23-19-36)37-20-24-39(66-8)25-21-37/h10-12,16-25,29,31-33,40,42-43,47H,14,27-28,30H2,1-9H3,(H,56,64)(H2,57,58,59,62,63)/t40-,42-,43-,47-,72?/m1/s1

Synonyms: 7-deaza 7-propargyl 2'-O-Methyl G(iBu) 3'-CE phosphoramidite

Amino Modifier 2'-O-Methyl Uridine CED phosphoramidite

Description: Amino Modifier 2'-O-Methyl Uridine CED phosphoramidite is a specialized reagent used in oligonucleotide synthesis to introduce a modification at the 2'-position of the ribose sugar of uridine. Additionally, it features a cyanoethyl (CED) protecting group, facilitating its incorporation into oligonucleotides during solid-phase synthesis. This reagent allows for the synthesis of oligonucleotides with specific chemical modifications, suitable for various research and diagnostic applications in molecular biology and biotechnology.

CAT: BRP-01394

MF: C51H64F3N6O11P

MF: 1025.06

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InChIKey: GOWRXIMHDVBFES-MVOVHUSBSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-5-((E)-3-oxo-3-((6-(2,2,2-trifluoroacetamido)hexyl)amino)prop-1-en-1-yl)-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C51H64F3N6O11P/c1-34(2)60(35(3)4)72(69-31-15-28-55)71-44-42(33-68-50(37-16-11-10-12-17-37,38-19-23-40(65-5)24-20-38)39-21-25-41(66-6)26-22-39)70-47(45(44)67-7)59-32-36(46(62)58-49(59)64)18-27-43(61)56-29-13-8-9-14-30-57-48(63)51(52,53)54/h10-12,16-27,32,34-35,42,44-45,47H,8-9,13-15,29-31,33H2,1-7H3,(H,56,61)(H,57,63)(H,58,62,64)/b27-18+/t42-,44-,45-,47-,72?/m1/s1

Synonyms: Amino Modifier 2'-O-Methyl Uridine 3'-CE phosphoramidite