Phosphoramidites - RNA / BOC Sciences

5'-DMT-2'-F-dA(Bz)-3'-PS-Phosphoramidite

Description: 5'-DMT-2'-F-dA(Bz)-3'-PS-Phosphoramidite is a phosphoramidite reagent used in the synthesis of modified nucleic acids. This reagent is used in automated DNA and RNA synthesis platforms to create modified oligonucleotides with precise sequences. These modifications are particularly valuable in various biomedical research applications, including gene therapy, antisense technology, and molecular diagnostics, where enhanced stability, specificity, and functional properties of nucleic acids are crucial.

CAT: BRP-01569

MF: C51H50FN6O7PS2

MF: 973.09

Purity: ≥90% by HPLC

Appearance: White to yellow powder

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InChIKey: PPULOMKIQMTGHV-PDBKPMKASA-N

IUPAC Name: S-(2-(((((2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl)oxy)(pyrrolidin-1-yl)phosphaneyl)thio)ethyl) benzothioate

InChI: InChI=1S/C51H50FN6O7PS2/c1-61-40-24-20-38(21-25-40)51(37-18-10-5-11-19-37,39-22-26-41(62-2)27-23-39)63-32-42-45(65-66(57-28-12-13-29-57)68-31-30-67-50(60)36-16-8-4-9-17-36)43(52)49(64-42)58-34-55-44-46(53-33-54-47(44)58)56-48(59)35-14-6-3-7-15-35/h3-11,14-27,33-34,42-43,45,49H,12-13,28-32H2,1-2H3,(H,53,54,56,59)/t42-,43-,45-,49-,66?/m1/s1

Synonyms: [N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-deoxyadenosine]-3'-[S-(β-(Benzoylmercapto)ethyl) Pyrrolidino Thiophosphoroamidite]; DMT-2'-F-dA(Bz)-3'-PS; 2'-F-dA-Thiophosphoramidite; 2'-F-dA(Bz)-Thiophosphoramidite

5'-DMT-2'-F-dU-3'-PS-Phosphoramidite

Description: 5'-DMT-2'-F-dU-3'-PS-Phosphoramidite is a phosphoramidite reagent used in the synthesis of modified nucleic acids. It is an essential reagent in automated DNA and RNA synthesis platforms, enabling the precise and reliable incorporation of modified uridine nucleotides into sequence-defined oligonucleotides. These modifications are particularly valuable in various biomedical research applications, including gene therapy, antisense technology, and molecular diagnostics, where enhanced stability, specificity, and functional properties of nucleic acids are crucial.

CAT: BRP-01570

MF: C43H45FN3O8PS2

MF: 845.93

Purity: ≥90% by HPLC

Appearance: White to yellow powder

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InChIKey: HUXZGSPNSAYIPS-CYSIDSPMSA-N

IUPAC Name: S-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluorotetrahydrofuran-3-yl)oxy)(pyrrolidin-1-yl)phosphaneyl)thio)ethyl) benzothioate

InChI: InChI=1S/C43H45FN3O8PS2/c1-51-34-19-15-32(16-20-34)43(31-13-7-4-8-14-31,33-17-21-35(52-2)22-18-33)53-29-36-39(38(44)40(54-36)47-26-23-37(48)45-42(47)50)55-56(46-24-9-10-25-46)58-28-27-57-41(49)30-11-5-3-6-12-30/h3-8,11-23,26,36,38-40H,9-10,24-25,27-29H2,1-2H3,(H,45,48,50)/t36-,38-,39-,40-,56?/m1/s1

Synonyms: [5'-O-(4,4'-Dimethoxytrityl)-2'-fluoro-deoxyuridine]-3'-[S-(β-(Benzoylmercapto)ethyl)Pyrrolidino Thiophosphoroamidite]; DMT-2'-F-dU-3'-PS; 2'-F-dU-Thiophosphoramidite

5'-O-(4,4'-Dimethoxytrityl)-2'-fluoro-deoxy-arabinoinosine-3'-[(2-cyanoethyl)-(N,N-diisopropropyl)]-Phosphoramidite

Description: 5'-O-DMTr-2'-ara-F-I-3'-CE-Phosphoramidite is a specialized phosphoramidite reagent used in the synthesis of modified oligonucleotides. It is valuable in developing oligonucleotides for various applications, including gene regulation, antisense therapy, and RNA interference (RNAi). Additionally, it supports research into nucleic acid structure, function, and interactions.

CAT: BRP-01571

MF: C40H46FN6O7P

MF: 772.80

Purity: ≥95% by HPLC

Appearance: Colorless to light yellow crystalline or white, off-white to light yellow amorphous dry powder

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InChIKey: GNQYQPLUWSYXRR-CAPOITNRSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1F)N2C=NC3=C2N=CNC3=O)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: 3-[[(2R,3R,4S,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-fluoro-5-(6-oxo-1H-purin-9-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C40H46FN6O7P/c1-26(2)47(27(3)4)55(52-22-10-21-42)54-36-33(53-39(34(36)41)46-25-45-35-37(46)43-24-44-38(35)48)23-51-40(28-11-8-7-9-12-28,29-13-17-31(49-5)18-14-29)30-15-19-32(50-6)20-16-30/h7-9,11-20,24-27,33-34,36,39H,10,22-23H2,1-6H3,(H,43,44,48)/t33-,34+,36-,39-,55?/m1/s1

Synonyms: 5'-O-DMTr-2'-ara-F-I-3'-CE-Phosphoramidite; (2R,3R,4S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; 2'-Fluoro-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-arabinoinosine-3'-CE-Phosphoramidite

2'-F U Me-amidite

Description: 2'-F U Me-amidite is a phosphoramidite reagent used in the chemical synthesis of DNA oligonucleotides. This compound includes a 5'-O-DMTr protective group to safeguard the 5' hydroxyl group during synthesis, a 2'-fluorine modification to enhance stability against enzymatic degradation, and a 3'-methyl phosphoramidite for efficient incorporation into the growing DNA chain. This reagent is essential for creating modified DNA sequences with improved stability and integrity, suitable for various research and therapeutic applications.

CAT: BRP-01576

MF: C37H45FN3O7P

MF: 693.75

Purity: >95%

Appearance: Off-white solid

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InChIKey: XUSXWHAYFLUNDK-CGZUQJDWSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(C)OC1C(OC(C1F)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: 1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[[di(propan-2-yl)amino]-methylphosphanyl]oxy-3-fluorooxolan-2-yl]pyrimidine-2,4-dione

InChI: InChI=1S/C37H45FN3O7P/c1-24(2)41(25(3)4)49(7)48-34-31(47-35(33(34)38)40-22-21-32(42)39-36(40)43)23-46-37(26-11-9-8-10-12-26,27-13-17-29(44-5)18-14-27)28-15-19-30(45-6)20-16-28/h8-22,24-25,31,33-35H,23H2,1-7H3,(H,39,42,43)/t31-,33-,34-,35-,49?/m1/s1

Synonyms: 5'-O-(4,4'-Dimethoxytrityl)-2'-fluoro-2'-deoxyuridine-3'-Methyl-phosphoramidite; 5'-O-DMTr-2'-F-dU-3'-Methyl-phosphoramidite; 2'-F-dU-3'-Methyl-phosphoramidite; 1-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((diisopropylamino)(methyl)phosphaneyl)oxy)-3-fluorotetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; 2'-F dU Me-amidite

2'-F C(Ac) Me-amidite

Description: 2'-F C(Ac) Me-amidite is a phosphoramidite reagent used in the synthesis of modified DNA oligonucleotides. It allows for the controlled synthesis of DNA oligonucleotides with modified cytidine bases. These modifications enhance the stability, functionality, and specificity of the resulting oligonucleotide, making it valuable for various research and biomedical applications.

CAT: BRP-01577

MF: C39H48FN4O7P

MF: 734.81

Purity: >95%

Appearance: Off-white solid

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InChIKey: KBVMZEMFKQCECY-SGXIJWRWSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: N-(1-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((diisopropylamino)(methyl)phosphaneyl)oxy)-3-fluorotetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide

InChI: InChI=1S/C39H48FN4O7P/c1-25(2)44(26(3)4)52(8)51-36-33(50-37(35(36)40)43-23-22-34(41-27(5)45)42-38(43)46)24-49-39(28-12-10-9-11-13-28,29-14-18-31(47-6)19-15-29)30-16-20-32(48-7)21-17-30/h9-23,25-26,33,35-37H,24H2,1-8H3,(H,41,42,45,46)/t33-,35-,36-,37-,52?/m1/s1

Synonyms: N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxycytidine-3'-Methyl-phosphoramidite; 5'-O-DMTr-2'-F-dC(Ac)-3'-Methyl-phosphoramidite; 2'-F-Ac-dC-3'-Methyl-phosphoramidite; 2'-F dC(Ac) Me-amidite; 2'-F cytidine (N-Ac) methyl phosphoramidite

2'-F A(Bz) Me-amidite

Description: 2'-F A(Bz) Me-amidite is a phosphoramidite reagent utilized in the synthesis of DNA oligonucleotides. This compound features a benzoyl group at the N6 position of the adenine base, providing protection during synthesis. The 5'-O-(4,4'-dimethoxytrityl) group shields the 5' hydroxyl group of the nucleoside, facilitating controlled assembly of the oligonucleotide chain. A fluorine atom at the 2' position of the deoxyribose sugar enhances the oligonucleotide's stability against enzymatic degradation. The 3'-methyl phosphoramidite moiety enables efficient coupling reactions for precise incorporation into DNA sequences, essential for various biomedical and genetic applications.

CAT: BRP-01578

MF: C45H50FN6O6P

MF: 820.90

Purity: >95%

Appearance: Off-white solid

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InChIKey: UCNMOPCADOGMJE-GBNBITQMSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((diisopropylamino)(methyl)phosphaneyl)oxy)-3-fluorotetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide

InChI: InChI=1S/C45H50FN6O6P/c1-29(2)52(30(3)4)59(7)58-40-37(57-44(38(40)46)51-28-49-39-41(47-27-48-42(39)51)50-43(53)31-14-10-8-11-15-31)26-56-45(32-16-12-9-13-17-32,33-18-22-35(54-5)23-19-33)34-20-24-36(55-6)25-21-34/h8-25,27-30,37-38,40,44H,26H2,1-7H3,(H,47,48,50,53)/t37-,38-,40-,44-,59?/m1/s1

Synonyms: N6-Bz-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxyadenosine-3'-methyl-phosphoramidite; 5'-O-DMTr-2'-F-dA(Bz)-3'-methyl-phosphoramidite; 2'-F dA(Bz) Me-amidite; 2'-F adenosine (N-Bz) methyl phosphoramidite

2'-F G(iBu) Me-amidite

Description: 2'-F G(iBu) Me-amidite is a phosphoramidite reagent used in DNA oligonucleotide synthesis. It incorporates a modified guanine nucleotide with a fluorine atom at the 2' position of the sugar, enhancing stability against enzymatic degradation. The nucleoside is protected at the 5' position with a 4,4'-dimethoxytrityl group and at the N2 position with an isobutyryl group, facilitating controlled synthesis and modification of DNA sequences for diverse biological and therapeutic applications.

CAT: BRP-01579

MF: C42H52FN6O7P

MF: 802.88

Purity: >95%

Appearance: Off-white solid

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InChIKey: CCVHKDPSLDLLHS-CDTSKKGKSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((diisopropylamino)(methyl)phosphaneyl)oxy)-3-fluorotetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide

InChI: InChI=1S/C42H52FN6O7P/c1-25(2)38(50)46-41-45-37-35(39(51)47-41)44-24-48(37)40-34(43)36(56-57(9)49(26(3)4)27(5)6)33(55-40)23-54-42(28-13-11-10-12-14-28,29-15-19-31(52-7)20-16-29)30-17-21-32(53-8)22-18-30/h10-22,24-27,33-34,36,40H,23H2,1-9H3,(H2,45,46,47,50,51)/t33-,34-,36-,40-,57?/m1/s1

Synonyms: N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxyguanosine-3'-methyl-phosphoramidite; 5'-O-DMTr-2'-F-dG(iBu)-3'-methyl-phosphoramidite; 2'-F dG(iBu) Me-amidite; 2'-F Guanosine (n-ibu) methyl phosphoramidite

ANA 2'-F MeC(Bz) amidite

Description: N4-Benzoyl-1-(2'-deoxy-5'-O-DMT-2'-fluoro-β-D-arabinofuranosyl)-5-methylcytosine 3'-CE phosphoramidite is utilized in the synthesis of modified oligonucleotides to enhance their stability, binding affinity, and resistance to enzymatic degradation, making it a valuable tool for developing therapeutic nucleic acids, such as antisense oligonucleotides and siRNAs, as well as for studying nucleic acid interactions and processes in biochemical research.

CAT: BRP-01580

MF: C47H53FN5O8P

MF: 865.94

Purity: >95%

Appearance: Off-white solid

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InChIKey: XYPAFCMPDQWTME-MCYFHWMRSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC1=CN(C(=O)N=C1NC(=O)C2=CC=CC=C2)C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N(C(C)C)C(C)C)OCCC#N)F

IUPAC Name: N-[1-[(2R,3S,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-fluorooxolan-2-yl]-5-methyl-2-oxopyrimidin-4-yl]benzamide

InChI: InChI=1S/C47H53FN5O8P/c1-31(2)53(32(3)4)62(59-28-14-27-49)61-42-40(60-45(41(42)48)52-29-33(5)43(51-46(52)55)50-44(54)34-15-10-8-11-16-34)30-58-47(35-17-12-9-13-18-35,36-19-23-38(56-6)24-20-36)37-21-25-39(57-7)26-22-37/h8-13,15-26,29,31-32,40-42,45H,14,28,30H2,1-7H3,(H,50,51,54,55)/t40-,41+,42-,45-,62?/m1/s1

Synonyms: N4-Benzoyl-1-(2'-deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)-5-methylcytosine 3'-CE phosphoramidite; (2R,3R,4S,5R)-5-(4-benzamido-5-methyl-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

2'-F N1-Methyl PseudoUridine amidite

Description: 2'-F N1-Methyl PseudoUridine amidite is employed in the solid-phase synthesis of modified oligonucleotides. It is a powerful tool in the synthesis of stable and effective modified oligonucleotides for research and therapeutic purposes.

CAT: BRP-01581

MF: C40H48FN4O8P

MF: 762.82

Purity: >95%

Appearance: Off-white solid

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InChIKey: VYDSFQVJLJFHSF-HRZVAZJQSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4S,5S)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C40H48FN4O8P/c1-26(2)45(27(3)4)54(51-23-11-22-42)53-37-34(52-36(35(37)41)33-24-44(5)39(47)43-38(33)46)25-50-40(28-12-9-8-10-13-28,29-14-18-31(48-6)19-15-29)30-16-20-32(49-7)21-17-30/h8-10,12-21,24,26-27,34-37H,11,23,25H2,1-7H3,(H,43,46,47)/t34-,35+,36+,37-,54?/m1/s1

Synonyms: N1-Me-5'-O-DMT-2'-fluoro-2'-Deoxy PseudoUridine 3'-CE phosphoramidite; 2'-F-N1-Me-pU amidite; 2'-Fluoro-N1-Me-pU-3'-phosphoramidite

2'-F C(Ac) OBn-amidite

Description: 2'-F C(Ac) OBn-amidite is a phosphoramidite reagent used in the synthesis of modified DNA oligonucleotides. It allows for the controlled synthesis of DNA oligonucleotides with modified cytidine bases. These modifications enhance the stability, functionality, and specificity of the resulting oligonucleotide, making it useful for various research and biomedical applications.

CAT: BRP-01582

MF: C45H52FN4O8P

MF: 826.90

Purity: >95%

Appearance: Off-white solid

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InChIKey: SHMALCARVZQMLW-ACVVKSTRSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl benzyl diisopropylphosphoramidite

InChI: InChI=1S/C45H52FN4O8P/c1-30(2)50(31(3)4)59(56-28-33-14-10-8-11-15-33)58-42-39(57-43(41(42)46)49-27-26-40(47-32(5)51)48-44(49)52)29-55-45(34-16-12-9-13-17-34,35-18-22-37(53-6)23-19-35)36-20-24-38(54-7)25-21-36/h8-27,30-31,39,41-43H,28-29H2,1-7H3,(H,47,48,51,52)/t39-,41-,42-,43-,59?/m1/s1

Synonyms: N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxycytidine-3'-benzyloxy-phosphoramidite; 5'-O-DMTr-2'-F-dC(Ac)-3'-benzyloxy-phosphoramidite; 2'-F-Ac-dC-3'-benzyloxy-phosphoramidite; 2'-F dC(Ac) OBn-amidite; 2'-F cytidine (N-Ac) benzyloxy phosphoramidite

2'-F A(Bz) OBn-amidite

Description: 2'-F A(Bz) OBn-amidite is a phosphoramidite reagent used in the synthesis of modified DNA oligonucleotides. It enables the controlled synthesis of DNA oligonucleotides with modified adenine bases. These modifications enhance the stability, functionality, and specificity of the resulting oligonucleotide, making it valuable for various research and biomedical applications.

CAT: BRP-01583

MF: C51H54FN6O7P

MF: 913.00

Purity: >95%

Appearance: Off-white solid

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InChIKey: DULYHLZNELEDNC-RLRGUIIOSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl benzyl diisopropylphosphoramidite

InChI: InChI=1S/C51H54FN6O7P/c1-34(2)58(35(3)4)66(63-30-36-16-10-7-11-17-36)65-46-43(64-50(44(46)52)57-33-55-45-47(53-32-54-48(45)57)56-49(59)37-18-12-8-13-19-37)31-62-51(38-20-14-9-15-21-38,39-22-26-41(60-5)27-23-39)40-24-28-42(61-6)29-25-40/h7-29,32-35,43-44,46,50H,30-31H2,1-6H3,(H,53,54,56,59)/t43-,44-,46-,50-,66?/m1/s1

Synonyms: N6-Bz-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxyadenosine-3'-benzyloxy-phosphoramidite; 5'-O-DMTr-2'-F-dA(Bz)-3'-benzyloxy-phosphoramidite; 2'-F dA(Bz) OBn-amidite; 2'-F adenosine (N-Bz) benzyloxy phosphoramidite

2'-F G(iBu) OBn-amidite

Description: 2'-F G(iBu) OBn-amidite is a phosphoramidite reagent used in the synthesis of modified DNA oligonucleotides. It facilitates the controlled synthesis of DNA oligonucleotides with modified guanosine bases. These modifications enhance the stability, functionality, and specificity of the resulting oligonucleotide, making it valuable for various research and biomedical applications.

CAT: BRP-01584

MF: C48H56FN6O8P

MF: 894.98

Purity: >95%

Appearance: Off-white solid

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InChIKey: NMMXCYLXXJOCAP-AUNSQTKWSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: benzyl ((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl) diisopropylphosphoramidite

InChI: InChI=1S/C48H56FN6O8P/c1-30(2)44(56)52-47-51-43-41(45(57)53-47)50-29-54(43)46-40(49)42(63-64(55(31(3)4)32(5)6)61-27-33-15-11-9-12-16-33)39(62-46)28-60-48(34-17-13-10-14-18-34,35-19-23-37(58-7)24-20-35)36-21-25-38(59-8)26-22-36/h9-26,29-32,39-40,42,46H,27-28H2,1-8H3,(H2,51,52,53,56,57)/t39-,40-,42-,46-,64?/m1/s1

Synonyms: N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxyguanosine-3'-benzyloxy-phosphoramidite; 5'-O-DMTr-2'-F-dG(iBu)-3'-benzyloxy-phosphoramidite; 2'-F dG(iBu) OBn-amidite; 2'-F Guanosine (n-ibu) benzyloxy phosphoramidite

2'-F U OBn-amidite

Description: 2'-F U OBn-amidite is a phosphoramidite reagent used in the synthesis of modified DNA oligonucleotides. It allows for the controlled synthesis of DNA oligonucleotides with modified uridine bases. These modifications enhance the stability, functionality, and specificity of the resulting oligonucleotide, making it valuable for various research and biomedical applications.

CAT: BRP-01585

MF: C43H49FN3O8P

MF: 785.85

Purity: >95%

Appearance: Off-white solid

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InChIKey: LXSZAXFOUHFKJS-APEVFGHTSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: benzyl ((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluorotetrahydrofuran-3-yl) diisopropylphosphoramidite

InChI: InChI=1S/C43H49FN3O8P/c1-29(2)47(30(3)4)56(53-27-31-13-9-7-10-14-31)55-40-37(54-41(39(40)44)46-26-25-38(48)45-42(46)49)28-52-43(32-15-11-8-12-16-32,33-17-21-35(50-5)22-18-33)34-19-23-36(51-6)24-20-34/h7-26,29-30,37,39-41H,27-28H2,1-6H3,(H,45,48,49)/t37-,39-,40-,41-,56?/m1/s1

Synonyms: 5'-O-(4,4'-Dimethoxytrityl)-2'-fluoro-2'-deoxyuridine-3'-benzyloxy-phosphoramidite; 5'-O-DMTr-2'-F-dU-3'-benzyloxy-phosphoramidite; 2'-F-dU-3'-benzyloxy-phosphoramidite; 2'-F dU OBn-amidite

2'-F G(iBu) (TBSO)SATE-amidite

Description: 2'-F G(iBu) (TBSO)SATE-amidite is a phosphoramidite reagent used in the synthesis of modified DNA oligonucleotides. It facilitates the controlled synthesis of DNA oligonucleotides with modified guanosine bases. These modifications enhance the stability, functionality, and specificity of the resulting oligonucleotide, making it valuable for various research and biomedical applications.

CAT: BRP-01586

MF: C54H76FN6O10PSSi

MF: 1079.36

Purity: >95%

Appearance: Off-white solid

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Storage: Store at -20 °C

InChIKey: AJSNCSZUDGUTOZ-WFDCMRDWSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: S-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethyl) 3-((tert-butyldimethylsilyl)oxy)-2,2-dimethylpropanethioate

InChI: InChI=1S/C54H76FN6O10PSSi/c1-34(2)47(62)58-51-57-46-44(48(63)59-51)56-33-60(46)49-43(55)45(71-72(61(35(3)4)36(5)6)68-29-30-73-50(64)53(10,11)32-69-74(14,15)52(7,8)9)42(70-49)31-67-54(37-19-17-16-18-20-37,38-21-25-40(65-12)26-22-38)39-23-27-41(66-13)28-24-39/h16-28,33-36,42-43,45,49H,29-32H2,1-15H3,(H2,57,58,59,62,63)/t42-,43-,45-,49-,72?/m1/s1

Synonyms: 2'-F dG(iBu) (TBSO)SATE-amidite; 2'-Fluoro-2'-deoxy Guanosine (N-iBu) 3'-O-(TBSO)SATE phosphoramidite

2'-F A(Bz) (TBSO)SATE-amidite

Description: 2'-F A(Bz) (TBSO)SATE-amidite is a phosphoramidite reagent used in the synthesis of modified DNA oligonucleotides. It enables the controlled synthesis of DNA oligonucleotides with modified adenine bases. These modifications enhance the stability, functionality, and specificity of the resulting oligonucleotide, making it valuable for various research and biomedical applications.

CAT: BRP-01587

MF: C57H74FN6O9PSSi

MF: 1097.38

Purity: >95%

Appearance: Off-white solid

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Storage: Store at -20 °C

InChIKey: PBYQXESREXFRID-RONWHNMCSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: S-(2-(((((2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethyl) 3-((tert-butyldimethylsilyl)oxy)-2,2-dimethylpropanethioate

InChI: InChI=1S/C57H74FN6O9PSSi/c1-38(2)64(39(3)4)74(70-32-33-75-54(66)56(8,9)35-71-76(12,13)55(5,6)7)73-49-46(72-53(47(49)58)63-37-61-48-50(59-36-60-51(48)63)62-52(65)40-20-16-14-17-21-40)34-69-57(41-22-18-15-19-23-41,42-24-28-44(67-10)29-25-42)43-26-30-45(68-11)31-27-43/h14-31,36-39,46-47,49,53H,32-35H2,1-13H3,(H,59,60,62,65)/t46-,47-,49-,53-,74?/m1/s1

Synonyms: 2'-F dA(Bz) (TBSO)SATE-amidite; 2'-Fluoro-2'-deoxy Adenosine (N-Bz) 3'-O-(TBSO)SATE phosphoramidite

2'-F C(Bz) (TBSO)SATE-amidite

Description: 2'-F C(Bz) (TBSO)SATE-amidite is a phosphoramidite reagent used in the synthesis of modified DNA oligonucleotides. It allows for the controlled synthesis of DNA oligonucleotides with modified cytidine bases. These modifications enhance the stability, functionality, and specificity of the resulting oligonucleotide, making it useful for various research and biomedical applications.

CAT: BRP-01588

MF: C56H74FN4O10PSSi

MF: 1073.35

Purity: >95%

Appearance: Off-white solid

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InChIKey: HVBZXHBXPNTSPC-CEJOASKFSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: S-(2-(((((2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethyl) 3-((tert-butyldimethylsilyl)oxy)-2,2-dimethylpropanethioate

InChI: InChI=1S/C56H74FN4O10PSSi/c1-38(2)61(39(3)4)72(68-34-35-73-52(63)55(8,9)37-69-74(12,13)54(5,6)7)71-49-46(70-51(48(49)57)60-33-32-47(59-53(60)64)58-50(62)40-20-16-14-17-21-40)36-67-56(41-22-18-15-19-23-41,42-24-28-44(65-10)29-25-42)43-26-30-45(66-11)31-27-43/h14-33,38-39,46,48-49,51H,34-37H2,1-13H3,(H,58,59,62,64)/t46-,48-,49-,51-,72?/m1/s1

Synonyms: 2'-F dC(Bz) (TBSO)SATE-amidite; 2'-Fluoro-2'-deoxy Cytidine (N-Bz) 3'-O-(TBSO)SATE phosphoramidite

2'-F U (TBSO)SATE-amidite

Description: 2'-F U (TBSO)SATE-amidite is a phosphoramidite reagent used in the synthesis of modified DNA oligonucleotides. It allows for the controlled synthesis of DNA oligonucleotides with modified uridine bases. These modifications enhance the stability, functionality, and specificity of the resulting oligonucleotide, making it valuable for various research and biomedical applications.

CAT: BRP-01589

MF: C49H69FN3O10PSSi

MF: 970.23

Purity: >95%

Appearance: Off-white solid

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Storage: Store at -20 °C

InChIKey: JADSOFLFIWRFSE-JISWKONASA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: S-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluorotetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethyl) 3-((tert-butyldimethylsilyl)oxy)-2,2-dimethylpropanethioate

InChI: InChI=1S/C49H69FN3O10PSSi/c1-33(2)53(34(3)4)64(60-29-30-65-45(55)48(8,9)32-61-66(12,13)47(5,6)7)63-43-40(62-44(42(43)50)52-28-27-41(54)51-46(52)56)31-59-49(35-17-15-14-16-18-35,36-19-23-38(57-10)24-20-36)37-21-25-39(58-11)26-22-37/h14-28,33-34,40,42-44H,29-32H2,1-13H3,(H,51,54,56)/t40-,42-,43-,44-,64?/m1/s1

Synonyms: 2'-F dU (TBSO)SATE-amidite; 2'-Fluoro-2'-deoxy Uridine 3'-O-(TBSO)SATE phosphoramidite

2'-F U Obutyn-amidite

CAT: BRP-01590

CAS: 1840885-37-1

MF: C40H47FN3O8P

MF: 747.80

Purity: >95%

Appearance: Off-white solid

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Storage: Store at -20 °C

InChIKey: MXTGLMKXIAYCPR-GFIGKZKCSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: O=C1C=CN(C(=O)N1)C2OC(COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)C(OP(OCCC#C)N(C(C)C)C(C)C)C2F

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluorotetrahydrofuran-3-yl but-3-yn-1-yl diisopropylphosphoramidite

InChI: InChI=1S/C40H47FN3O8P/c1-8-9-25-50-53(44(27(2)3)28(4)5)52-37-34(51-38(36(37)41)43-24-23-35(45)42-39(43)46)26-49-40(29-13-11-10-12-14-29,30-15-19-32(47-6)20-16-30)31-17-21-33(48-7)22-18-31/h1,10-24,27-28,34,36-38H,9,25-26H2,2-7H3,(H,42,45,46)/t34-,36-,37-,38-,53?/m1/s1

Synonyms: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-, 3'-[3-butyn-1-yl N,N-bis(1-methylethyl)phosphoramidite]; 2'-F dU Obutyn-amidite; 5'-O-(4,4'-Dimethoxytrityl)-2'-fluoro-2'-deoxyuridine-3'-Obutyn-phosphoramidite; 5'-O-DMTr-2'-F-dU-3'-Obutyn-phosphoramidite

2'-F C(Ac) Obutyn-amidite

Description: 2'-F C(Ac) Obutyn-amidite is a phosphoramidite reagent used in the synthesis of modified DNA oligonucleotides. It allows for the controlled synthesis of DNA oligonucleotides with modified cytidine bases. These modifications enhance the stability, functionality, and specificity of the resulting oligonucleotide, making it useful for various research and biomedical applications.

CAT: BRP-01591

CAS: 1840885-72-4

MF: C42H50FN4O8P

MF: 788.85

Purity: >95%

Appearance: Off-white solid

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InChIKey: PPGHLCKGBCZDSW-CYSIDSPMSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: O=C1N=C(C=CN1C2OC(COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)C(OP(OCCC#C)N(C(C)C)C(C)C)C2F)NC(=O)C

IUPAC Name: (2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl but-3-yn-1-yl diisopropylphosphoramidite

InChI: InChI=1S/C42H50FN4O8P/c1-9-10-26-53-56(47(28(2)3)29(4)5)55-39-36(54-40(38(39)43)46-25-24-37(44-30(6)48)45-41(46)49)27-52-42(31-14-12-11-13-15-31,32-16-20-34(50-7)21-17-32)33-18-22-35(51-8)23-19-33/h1,11-25,28-29,36,38-40H,10,26-27H2,2-8H3,(H,44,45,48,49)/t36-,38-,39-,40-,56?/m1/s1

Synonyms: Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-, 3'-[3-butyn-1-yl N,N-bis(1-methylethyl)phosphoramidite]; 2'-F dC(Ac) Obutyn-amidite; N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxycytidine-3'-Obutyn-phosphoramidite; 5'-O-DMTr-2'-F-dC(Ac)-3'-Obutyn-phosphoramidite

2'-Fluoro-2'-deoxy Cytidine (N-PAC) 3'-O-BMEG phosphoramidite

Description: 2'-Fluoro-2'-deoxy Cytidine (N-PAC) 3'-O-BMEG phosphoramidite is a phosphoramidite reagent crucial in the synthesis of modified nucleic acids. This compound is designed to introduce a modified cytidine nucleoside into oligonucleotide sequences with enhanced stability and functionality. It serves as an intermediate in automated DNA and RNA synthesis platforms, facilitating precise and reliable incorporation of modified nucleotides into sequence-defined oligonucleotides. This capability is instrumental in various biomedical research applications, including gene therapy, RNA interference (RNAi), and molecular diagnostics, where modified nucleic acids offer improved stability, specificity, and functionality.

CAT: BRP-01596

MF: C52H64FN4O11PS

MF: 1003.13

Purity: ≥95%

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InChIKey: ZACCDKZIIHZEBP-YDKKORBQSA-N

IUPAC Name: S-(2-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(2-oxo-4-(2-phenoxyacetamido)pyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethoxy)ethyl) 2-methylpropanethioate

InChI: InChI=1S/C52H64FN4O11PS/c1-35(2)50(59)70-32-31-63-29-30-66-69(57(36(3)4)37(5)6)68-48-44(67-49(47(48)53)56-28-27-45(55-51(56)60)54-46(58)34-64-43-17-13-10-14-18-43)33-65-52(38-15-11-9-12-16-38,39-19-23-41(61-7)24-20-39)40-21-25-42(62-8)26-22-40/h9-28,35-37,44,47-49H,29-34H2,1-8H3,(H,54,55,58,60)/t44-,47-,48-,49-,69?/m1/s1

Synonyms: 5'-O-DMTr-2'-F-dC(Pac)-3'-O-BMEG phosphoramidite