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Phosphoramidites

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2'-Modified Phosphoramidites
(529/529) 2'-Phosphoramidites
(27/27) 3'-Modified Phosphoramidites
(201/201) 5'-Modified Phosphoramidites
(30/30) Arabino Phosphoramidites
(23/23) Base Protected Phosphoramidites (418/418) Dye Phosphoramidites
(53/53) Label Phosphoramidites
(80/80) Linker Phosphoramidites
(85/85) Other Phosphoramidites
(97/97) PMO Phosphoramidates and Derivatives (33/33) PseudoUridine Phosphoramidite
(12/12) Reverse Phosphoramidites
(25/25) Spacer Phosphoramidites
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2'-Fluoro-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyinosine-3'-CE-Phosphoramidite

Description: 2'-Fluoro-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyinosine-3'-CE-Phosphoramidite is a specialized reagent used in oligonucleotide synthesis. It features a 2'-fluoro modification on the deoxyribose sugar of inosine (I), combined with a cyanoethyl (CE) phosphoramidite functional group necessary for solid-phase oligonucleotide synthesis. It is valuable in developing modified oligonucleotides for various applications, including as probes for studying nucleic acid structure, as well as potential therapeutic applications such as antisense therapy and RNA interference (RNAi).
CAT: BRP-01556
CAS: 2245842-16-2
Molecular Formula: C40H46FN6O7P
Molecular Weight: 772.80
Purity: ≥98% by HPLC
Appearance: White powder
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Storage: Store at -20 °C
InChIKey: GNQYQPLUWSYXRR-YRGZVQMCSA-N
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1F)N2C=NC3=C2N=CNC3=O)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC
IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-fluoro-5-(6-oxo-1H-purin-9-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
InChI: InChI=1S/C40H46FN6O7P/c1-26(2)47(27(3)4)55(52-22-10-21-42)54-36-33(53-39(34(36)41)46-25-45-35-37(46)43-24-44-38(35)48)23-51-40(28-11-8-7-9-12-28,29-13-17-31(49-5)18-14-29)30-15-19-32(50-6)20-16-30/h7-9,11-20,24-27,33-34,36,39H,10,22-23H2,1-6H3,(H,43,44,48)/t33-,34-,36-,39-,55?/m1/s1
Synonyms: 2'-F-dI-CE-Phosphoramidite; 2'-F I amidite; 2'-Fluoro-5'-O-DMT-2'-deoxyinosine-3'-CE-phosphoramidite; 5'-O-(4,4'-Dimethoxytrityl)-2'-fluoro-2'-deoxyinosine-3'-cyanoethyl phosphoramidite; 2'-F dI amidite

2'-F MeC(pac) amidite

Description: 2'-F MeC(pac) amidite is a phosphoramidite used in the chemical synthesis of RNA oligonucleotides. The 2'-fluorine modification enhances the stability of the RNA by increasing resistance to enzymatic degradation. The methylcytosine base modification can impact gene expression and epigenetic regulation. The phenoxyacetyl (pac) group serves as a protective group, ensuring the fidelity of synthesis. This amidite allows for the production of modified RNA sequences with improved stability and functional properties.
CAT: BRP-01557
Molecular Formula: C48H55FN5O9P
Molecular Weight: 895.97
Purity: >95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: PBAZJAWJLKEWTI-UVFJTNPGSA-N
Solubility: Soluble in Acetonitrile, DMF
IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(5-methyl-2-oxo-4-(2-phenoxyacetamido)pyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C48H55FN5O9P/c1-32(2)54(33(3)4)64(61-28-14-27-50)63-44-41(62-46(43(44)49)53-29-34(5)45(52-47(53)56)51-42(55)31-59-40-17-12-9-13-18-40)30-60-48(35-15-10-8-11-16-35,36-19-23-38(57-6)24-20-36)37-21-25-39(58-7)26-22-37/h8-13,15-26,29,32-33,41,43-44,46H,14,28,30-31H2,1-7H3,(H,51,52,55,56)/t41-,43-,44-,46-,64?/m1/s1
Synonyms: 5'-O-DMT-2'-F-MeC(pac) 3'-CE Phosphoramidite; 2'-F-MeC(pac) CE-Phosphoramidite; 2'-F-5-Me-dC(pac) CE-Phosphoramidite

2'-F MeC(dmf) amidite

Description: 2'-F MeC(dmf) amidite is a phosphoramidite used in the chemical synthesis of RNA oligonucleotides. This compound features a 2'-fluorine modification, which enhances the stability of the RNA by increasing its resistance to enzymatic degradation. The cytosine base in this amidite is methylated (MeC), which can play a role in gene expression and epigenetic regulation. The dimethylformamide (dmf) group acts as a protective group, ensuring the proper synthesis of the RNA strand by preventing unwanted side reactions. This amidite is crucial for producing modified RNA sequences with enhanced stability and functionality.
CAT: BRP-01558
Molecular Formula: C43H54FN6O7P
Molecular Weight: 816.91
Purity: >98%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: ADENSOMHVRAGEH-KZQAAKLLSA-N
Solubility: Soluble in Acetonitrile, DMF
IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(4-(((dimethylamino)methylene)amino)-5-methyl-2-oxopyrimidin-1(2H)-yl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C43H54FN6O7P/c1-29(2)50(30(3)4)58(55-25-13-24-45)57-39-37(56-41(38(39)44)49-26-31(5)40(47-42(49)51)46-28-48(6)7)27-54-43(32-14-11-10-12-15-32,33-16-20-35(52-8)21-17-33)34-18-22-36(53-9)23-19-34/h10-12,14-23,26,28-30,37-39,41H,13,25,27H2,1-9H3/t37-,38-,39-,41-,58?/m1/s1
Synonyms: 5'-O-DMT-2'-F-MeC(dmf) 3'-CE Phosphoramidite; 2'-F-MeC(dmf) CE-Phosphoramidite; 2'-F-5-Me-dC(dmf) CE-Phosphoramidite

2'-F A(dmf) amidite

Description: 2'-F A(dmf) amidite is a phosphoramidite used in the chemical synthesis of RNA oligonucleotides. This compound includes a 2'-fluorine modification, which enhances RNA stability by increasing resistance to enzymatic degradation. The adenine base in this amidite has a dimethylformamide (dmf) protective group, which helps prevent unwanted side reactions during the synthesis process. This modification is crucial for producing RNA sequences with improved stability and integrity, facilitating their use in various research and therapeutic applications.
CAT: BRP-01559
Molecular Formula: C43H52FN8O6P
Molecular Weight: 826.91
Purity: >98%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: NOGLCHLULIFCJH-ZXYFHBOTSA-N
Solubility: Soluble in Acetonitrile, DMF
IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(6-(((dimethylamino)methylene)amino)-9H-purin-9-yl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C43H52FN8O6P/c1-29(2)52(30(3)4)59(56-24-12-23-45)58-39-36(57-42(37(39)44)51-28-48-38-40(49-27-50(5)6)46-26-47-41(38)51)25-55-43(31-13-10-9-11-14-31,32-15-19-34(53-7)20-16-32)33-17-21-35(54-8)22-18-33/h9-11,13-22,26-30,36-37,39,42H,12,24-25H2,1-8H3/t36-,37-,39-,42-,59?/m1/s1
Synonyms: 2'-Fluoro-2'-deoxy Adenosine (N,N-DMF) CED Phosphoramidite; 5'-O-DMT-2'-F-A(dmf) 3'-CE Phosphoramidite; 2'-F-A(dmf) CE-Phosphoramidite; 2'-F-dA(dmf) 3'-CE-Phosphoramidite

2'-F A(pac) amidite

Description: 2'-F A(pac) amidite is a phosphoramidite used in the chemical synthesis of RNA oligonucleotides. The 2'-fluorine modification enhances the stability of the RNA by making it more resistant to enzymatic degradation. The adenine base in this amidite has a phenoxyacetyl (pac) protective group, which prevents unwanted side reactions during the synthesis process. This amidite is essential for producing RNA sequences with enhanced stability and integrity, making them suitable for various research and therapeutic applications.
CAT: BRP-01560
Molecular Formula: C48H53FN7O8P
Molecular Weight: 905.96
Purity: >95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: IPGFEHRBBLWVPH-NNMVWRAKSA-N
Solubility: Soluble in Acetonitrile, DMF
IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(6-(2-phenoxyacetamido)-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C48H53FN7O8P/c1-32(2)56(33(3)4)65(62-27-13-26-50)64-44-40(28-61-48(34-14-9-7-10-15-34,35-18-22-37(58-5)23-19-35)36-20-24-38(59-6)25-21-36)63-47(42(44)49)55-31-53-43-45(51-30-52-46(43)55)54-41(57)29-60-39-16-11-8-12-17-39/h7-12,14-25,30-33,40,42,44,47H,13,27-29H2,1-6H3,(H,51,52,54,57)/t40-,42-,44-,47-,65?/m1/s1
Synonyms: 2'-Fluoro-2'-deoxy Adenosine (Pac) CED Phosphoramidite; 5'-O-DMT-2'-F-A(Pac) 3'-CE Phosphoramidite; 2'-F-A(Pac) CE-Phosphoramidite; 2'-F-dA(Pac) 3'-CE-Phosphoramidite

2'-F C(pac) amidite

Description: 2'-F C(pac) amidite is a phosphoramidite used in the chemical synthesis of RNA oligonucleotides. The 2'-fluorine modification enhances the stability of the RNA by making it more resistant to enzymatic degradation. The cytosine base in this compound has a phenoxyacetyl (pac) group, which serves as a protective group during the synthesis process, preventing undesired reactions. This amidite allows for the production of RNA sequences with improved stability and integrity, facilitating various applications in research and therapeutics.
CAT: BRP-01561
Molecular Formula: C47H53FN5O9P
Molecular Weight: 881.94
Purity: >98%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: ARQJQDCNAYPRPA-DRPJRLOZSA-N
Solubility: Soluble in Acetonitrile, DMF
IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(2-oxo-4-(2-phenoxyacetamido)pyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C47H53FN5O9P/c1-32(2)53(33(3)4)63(60-29-13-27-49)62-44-40(61-45(43(44)48)52-28-26-41(51-46(52)55)50-42(54)31-58-39-16-11-8-12-17-39)30-59-47(34-14-9-7-10-15-34,35-18-22-37(56-5)23-19-35)36-20-24-38(57-6)25-21-36/h7-12,14-26,28,32-33,40,43-45H,13,29-31H2,1-6H3,(H,50,51,54,55)/t40-,43-,44-,45-,63?/m1/s1
Synonyms: 5'-O-DMT-2'-F-C(pac) 3'-CE Phosphoramidite; 2'-F-C(pac) CE-Phosphoramidite; 2'-F-dC(pac) CE-Phosphoramidite

2'-F G(iPr-pac) amidite

Description: 2'-F G(iPr-pac) amidite is a phosphoramidite used in the chemical synthesis of RNA oligonucleotides. This compound features a 2'-fluorine modification, which enhances RNA stability by increasing resistance to enzymatic degradation. The guanine base in this amidite is protected with an isopropyl phenoxyacetyl (iPr-pac) group, which prevents unwanted side reactions during the synthesis process. This amidite is crucial for producing RNA sequences with improved stability and integrity, facilitating their use in various research and therapeutic applications.
CAT: BRP-01562
Molecular Formula: C51H59FN7O9P
Molecular Weight: 964.04
Purity: >98%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: XMOAKDDRWSAKSB-PHZZPARGSA-N
Solubility: Soluble in Acetonitrile, DMF
IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(2-(2-(4-isopropylphenoxy)acetamido)-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C51H59FN7O9P/c1-32(2)35-15-21-41(22-16-35)64-30-43(60)55-50-56-47-45(48(61)57-50)54-31-58(47)49-44(52)46(68-69(66-28-12-27-53)59(33(3)4)34(5)6)42(67-49)29-65-51(36-13-10-9-11-14-36,37-17-23-39(62-7)24-18-37)38-19-25-40(63-8)26-20-38/h9-11,13-26,31-34,42,44,46,49H,12,28-30H2,1-8H3,(H2,55,56,57,60,61)/t42-,44-,46-,49-,69?/m1/s1
Synonyms: 5'-O-DMT-2'-F-G(iPr-pac) 3'-CE Phosphoramidite; 2'-F-G(iPr-pac) CE-Phosphoramidite; 2'-F-dG(iPr-pac) 3'-CE-Phosphoramidite

5'-DMT-2'-F-dG(iBu)-3'-PS-Phosphoramidite

Description: 5'-DMT-2'-F-dG(iBu)-3'-PS-Phosphoramidite is a phosphoramidite reagent used in the synthesis of modified nucleic acids. This reagent is instrumental in automated DNA and RNA synthesis platforms, enabling the precise and reliable incorporation of modified nucleotides into sequence-defined oligonucleotides. The modifications introduced by 5'-DMT-2'-F-dG(iBu)-3'-PS-Phosphoramidite are particularly valuable in various biomedical research applications, including gene therapy, antisense technology, and molecular diagnostics, where improved stability, specificity, and functional properties of nucleic acids are essential.
CAT: BRP-01567
Molecular Formula: C48H52FN6O8PS2
Molecular Weight: 955.07
Purity: ≥90% by HPLC
Appearance: White to yellow powder
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Storage: Store at -20 °C
InChIKey: GOLSECBBKDTIRM-IMYAOLGDSA-N
CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N7CCCC7)SCCSC(=O)C8=CC=CC=C8)F
IUPAC Name: S-[2-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-fluoro-5-[2-(2-methylpropanoylamino)-6-oxo-1H-purin-9-yl]oxolan-3-yl]oxy-pyrrolidin-1-ylphosphanyl]sulfanylethyl] benzenecarbothioate
InChI: InChI=1S/C48H52FN6O8PS2/c1-31(2)43(56)52-47-51-42-40(44(57)53-47)50-30-55(42)45-39(49)41(63-64(54-25-11-12-26-54)66-28-27-65-46(58)32-13-7-5-8-14-32)38(62-45)29-61-48(33-15-9-6-10-16-33,34-17-21-36(59-3)22-18-34)35-19-23-37(60-4)24-20-35/h5-10,13-24,30-31,38-39,41,45H,11-12,25-29H2,1-4H3,(H2,51,52,53,56,57)/t38-,39-,41-,45-,64?/m1/s1
Synonyms: [N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-deoxyguanosine]-3'-[S-(β-(Benzoylmercapto)ethyl) Pyrrolidino Thiophosphoroamidite]; S-(2-(((((2R,3R,4R,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(2-isobutyramido-6-oxo-1H-purin-9(6H)-yl)tetrahydrofuran-3-yl)oxy)(pyrrolidin-1-yl)phosphino)thio)ethyl) benzothioate; DMT-2'-F-dG(iBu)-3'-PS; 2'-F-dG-Thiophosphoramidite; 2'-F-dG(iBu)-Thiophosphoramidite

5'-DMT-2'-F-dC(Ac)-3'-PS-Phosphoramidite

Description: 5'-DMT-2'-F-dC(Ac)-3'-PS-Phosphoramidite is a phosphoramidite reagent used in the synthesis of modified nucleic acids. It is an essential reagent in automated DNA and RNA synthesis platforms, enabling the precise and reliable incorporation of modified cytidine nucleotides into sequence-defined oligonucleotides. These modifications are particularly valuable in various biomedical research applications, including gene therapy, antisense technology, and molecular diagnostics, where enhanced stability, specificity, and functional properties of nucleic acids are crucial.
CAT: BRP-01568
Molecular Formula: C45H48FN4O8PS2
Molecular Weight: 886.99
Purity: ≥90% by HPLC
Appearance: White to yellow powder
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Storage: Store at -20 °C
InChIKey: YEUOGNRGLBQTSU-ZMHKPELYSA-N
IUPAC Name: S-(2-(((((2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl)oxy)(pyrrolidin-1-yl)phosphaneyl)thio)ethyl) benzothioate
InChI: InChI=1S/C45H48FN4O8PS2/c1-31(51)47-39-24-27-50(44(53)48-39)42-40(46)41(58-59(49-25-10-11-26-49)61-29-28-60-43(52)32-12-6-4-7-13-32)38(57-42)30-56-45(33-14-8-5-9-15-33,34-16-20-36(54-2)21-17-34)35-18-22-37(55-3)23-19-35/h4-9,12-24,27,38,40-42H,10-11,25-26,28-30H2,1-3H3,(H,47,48,51,53)/t38-,40-,41-,42-,59?/m1/s1
Synonyms: N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-deoxycytidine-3'-[S-(β-(Benzoylmercapto)ethyl) Pyrrolidino Thiophosphoramidite]; DMT-2'-F-dC(Ac)-3'-PS; 2'-F-dC-Thiophosphoramidite; 2'-F-dC(Ac)-Thiophosphoramidite

5'-DMT-2'-F-dA(Bz)-3'-PS-Phosphoramidite

Description: 5'-DMT-2'-F-dA(Bz)-3'-PS-Phosphoramidite is a phosphoramidite reagent used in the synthesis of modified nucleic acids. This reagent is used in automated DNA and RNA synthesis platforms to create modified oligonucleotides with precise sequences. These modifications are particularly valuable in various biomedical research applications, including gene therapy, antisense technology, and molecular diagnostics, where enhanced stability, specificity, and functional properties of nucleic acids are crucial.
CAT: BRP-01569
Molecular Formula: C51H50FN6O7PS2
Molecular Weight: 973.09
Purity: ≥90% by HPLC
Appearance: White to yellow powder
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Storage: Store at -20 °C
InChIKey: PPULOMKIQMTGHV-PDBKPMKASA-N
IUPAC Name: S-(2-(((((2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl)oxy)(pyrrolidin-1-yl)phosphaneyl)thio)ethyl) benzothioate
InChI: InChI=1S/C51H50FN6O7PS2/c1-61-40-24-20-38(21-25-40)51(37-18-10-5-11-19-37,39-22-26-41(62-2)27-23-39)63-32-42-45(65-66(57-28-12-13-29-57)68-31-30-67-50(60)36-16-8-4-9-17-36)43(52)49(64-42)58-34-55-44-46(53-33-54-47(44)58)56-48(59)35-14-6-3-7-15-35/h3-11,14-27,33-34,42-43,45,49H,12-13,28-32H2,1-2H3,(H,53,54,56,59)/t42-,43-,45-,49-,66?/m1/s1
Synonyms: [N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-deoxyadenosine]-3'-[S-(β-(Benzoylmercapto)ethyl) Pyrrolidino Thiophosphoroamidite]; DMT-2'-F-dA(Bz)-3'-PS; 2'-F-dA-Thiophosphoramidite; 2'-F-dA(Bz)-Thiophosphoramidite

5'-DMT-2'-F-dU-3'-PS-Phosphoramidite

Description: 5'-DMT-2'-F-dU-3'-PS-Phosphoramidite is a phosphoramidite reagent used in the synthesis of modified nucleic acids. It is an essential reagent in automated DNA and RNA synthesis platforms, enabling the precise and reliable incorporation of modified uridine nucleotides into sequence-defined oligonucleotides. These modifications are particularly valuable in various biomedical research applications, including gene therapy, antisense technology, and molecular diagnostics, where enhanced stability, specificity, and functional properties of nucleic acids are crucial.
CAT: BRP-01570
Molecular Formula: C43H45FN3O8PS2
Molecular Weight: 845.93
Purity: ≥90% by HPLC
Appearance: White to yellow powder
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Storage: Store at -20 °C
InChIKey: HUXZGSPNSAYIPS-CYSIDSPMSA-N
IUPAC Name: S-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluorotetrahydrofuran-3-yl)oxy)(pyrrolidin-1-yl)phosphaneyl)thio)ethyl) benzothioate
InChI: InChI=1S/C43H45FN3O8PS2/c1-51-34-19-15-32(16-20-34)43(31-13-7-4-8-14-31,33-17-21-35(52-2)22-18-33)53-29-36-39(38(44)40(54-36)47-26-23-37(48)45-42(47)50)55-56(46-24-9-10-25-46)58-28-27-57-41(49)30-11-5-3-6-12-30/h3-8,11-23,26,36,38-40H,9-10,24-25,27-29H2,1-2H3,(H,45,48,50)/t36-,38-,39-,40-,56?/m1/s1
Synonyms: [5'-O-(4,4'-Dimethoxytrityl)-2'-fluoro-deoxyuridine]-3'-[S-(β-(Benzoylmercapto)ethyl)Pyrrolidino Thiophosphoroamidite]; DMT-2'-F-dU-3'-PS; 2'-F-dU-Thiophosphoramidite

5'-O-(4,4'-Dimethoxytrityl)-2'-fluoro-deoxy-arabinoinosine-3'-[(2-cyanoethyl)-(N,N-diisopropropyl)]-Phosphoramidite

Description: 5'-O-DMTr-2'-ara-F-I-3'-CE-Phosphoramidite is a specialized phosphoramidite reagent used in the synthesis of modified oligonucleotides. It is valuable in developing oligonucleotides for various applications, including gene regulation, antisense therapy, and RNA interference (RNAi). Additionally, it supports research into nucleic acid structure, function, and interactions.
CAT: BRP-01571
Molecular Formula: C40H46FN6O7P
Molecular Weight: 772.80
Purity: ≥95% by HPLC
Appearance: Colorless to light yellow crystalline or white, off-white to light yellow amorphous dry powder
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Storage: Store at -20 °C
InChIKey: GNQYQPLUWSYXRR-CAPOITNRSA-N
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1F)N2C=NC3=C2N=CNC3=O)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC
IUPAC Name: 3-[[(2R,3R,4S,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-fluoro-5-(6-oxo-1H-purin-9-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
InChI: InChI=1S/C40H46FN6O7P/c1-26(2)47(27(3)4)55(52-22-10-21-42)54-36-33(53-39(34(36)41)46-25-45-35-37(46)43-24-44-38(35)48)23-51-40(28-11-8-7-9-12-28,29-13-17-31(49-5)18-14-29)30-15-19-32(50-6)20-16-30/h7-9,11-20,24-27,33-34,36,39H,10,22-23H2,1-6H3,(H,43,44,48)/t33-,34+,36-,39-,55?/m1/s1
Synonyms: 5'-O-DMTr-2'-ara-F-I-3'-CE-Phosphoramidite; (2R,3R,4S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; 2'-Fluoro-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-arabinoinosine-3'-CE-Phosphoramidite

2'-F U Me-amidite

Description: 2'-F U Me-amidite is a phosphoramidite reagent used in the chemical synthesis of DNA oligonucleotides. This compound includes a 5'-O-DMTr protective group to safeguard the 5' hydroxyl group during synthesis, a 2'-fluorine modification to enhance stability against enzymatic degradation, and a 3'-methyl phosphoramidite for efficient incorporation into the growing DNA chain. This reagent is essential for creating modified DNA sequences with improved stability and integrity, suitable for various research and therapeutic applications.
CAT: BRP-01576
Molecular Formula: C37H45FN3O7P
Molecular Weight: 693.75
Purity: >95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: XUSXWHAYFLUNDK-CGZUQJDWSA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: CC(C)N(C(C)C)P(C)OC1C(OC(C1F)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC
IUPAC Name: 1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[[di(propan-2-yl)amino]-methylphosphanyl]oxy-3-fluorooxolan-2-yl]pyrimidine-2,4-dione
InChI: InChI=1S/C37H45FN3O7P/c1-24(2)41(25(3)4)49(7)48-34-31(47-35(33(34)38)40-22-21-32(42)39-36(40)43)23-46-37(26-11-9-8-10-12-26,27-13-17-29(44-5)18-14-27)28-15-19-30(45-6)20-16-28/h8-22,24-25,31,33-35H,23H2,1-7H3,(H,39,42,43)/t31-,33-,34-,35-,49?/m1/s1
Synonyms: 5'-O-(4,4'-Dimethoxytrityl)-2'-fluoro-2'-deoxyuridine-3'-Methyl-phosphoramidite; 5'-O-DMTr-2'-F-dU-3'-Methyl-phosphoramidite; 2'-F-dU-3'-Methyl-phosphoramidite; 1-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((diisopropylamino)(methyl)phosphaneyl)oxy)-3-fluorotetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; 2'-F dU Me-amidite

2'-F C(Ac) Me-amidite

Description: 2'-F C(Ac) Me-amidite is a phosphoramidite reagent used in the synthesis of modified DNA oligonucleotides. It allows for the controlled synthesis of DNA oligonucleotides with modified cytidine bases. These modifications enhance the stability, functionality, and specificity of the resulting oligonucleotide, making it valuable for various research and biomedical applications.
CAT: BRP-01577
Molecular Formula: C39H48FN4O7P
Molecular Weight: 734.81
Purity: >95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: KBVMZEMFKQCECY-SGXIJWRWSA-N
Solubility: Soluble in Acetonitrile, DMF
IUPAC Name: N-(1-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((diisopropylamino)(methyl)phosphaneyl)oxy)-3-fluorotetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide
InChI: InChI=1S/C39H48FN4O7P/c1-25(2)44(26(3)4)52(8)51-36-33(50-37(35(36)40)43-23-22-34(41-27(5)45)42-38(43)46)24-49-39(28-12-10-9-11-13-28,29-14-18-31(47-6)19-15-29)30-16-20-32(48-7)21-17-30/h9-23,25-26,33,35-37H,24H2,1-8H3,(H,41,42,45,46)/t33-,35-,36-,37-,52?/m1/s1
Synonyms: N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxycytidine-3'-Methyl-phosphoramidite; 5'-O-DMTr-2'-F-dC(Ac)-3'-Methyl-phosphoramidite; 2'-F-Ac-dC-3'-Methyl-phosphoramidite; 2'-F dC(Ac) Me-amidite; 2'-F cytidine (N-Ac) methyl phosphoramidite

2'-F A(Bz) Me-amidite

Description: 2'-F A(Bz) Me-amidite is a phosphoramidite reagent utilized in the synthesis of DNA oligonucleotides. This compound features a benzoyl group at the N6 position of the adenine base, providing protection during synthesis. The 5'-O-(4,4'-dimethoxytrityl) group shields the 5' hydroxyl group of the nucleoside, facilitating controlled assembly of the oligonucleotide chain. A fluorine atom at the 2' position of the deoxyribose sugar enhances the oligonucleotide's stability against enzymatic degradation. The 3'-methyl phosphoramidite moiety enables efficient coupling reactions for precise incorporation into DNA sequences, essential for various biomedical and genetic applications.
CAT: BRP-01578
Molecular Formula: C45H50FN6O6P
Molecular Weight: 820.90
Purity: >95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: UCNMOPCADOGMJE-GBNBITQMSA-N
Solubility: Soluble in Acetonitrile, DMF
IUPAC Name: N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((diisopropylamino)(methyl)phosphaneyl)oxy)-3-fluorotetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide
InChI: InChI=1S/C45H50FN6O6P/c1-29(2)52(30(3)4)59(7)58-40-37(57-44(38(40)46)51-28-49-39-41(47-27-48-42(39)51)50-43(53)31-14-10-8-11-15-31)26-56-45(32-16-12-9-13-17-32,33-18-22-35(54-5)23-19-33)34-20-24-36(55-6)25-21-34/h8-25,27-30,37-38,40,44H,26H2,1-7H3,(H,47,48,50,53)/t37-,38-,40-,44-,59?/m1/s1
Synonyms: N6-Bz-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxyadenosine-3'-methyl-phosphoramidite; 5'-O-DMTr-2'-F-dA(Bz)-3'-methyl-phosphoramidite; 2'-F dA(Bz) Me-amidite; 2'-F adenosine (N-Bz) methyl phosphoramidite

2'-F G(iBu) Me-amidite

Description: 2'-F G(iBu) Me-amidite is a phosphoramidite reagent used in DNA oligonucleotide synthesis. It incorporates a modified guanine nucleotide with a fluorine atom at the 2' position of the sugar, enhancing stability against enzymatic degradation. The nucleoside is protected at the 5' position with a 4,4'-dimethoxytrityl group and at the N2 position with an isobutyryl group, facilitating controlled synthesis and modification of DNA sequences for diverse biological and therapeutic applications.
CAT: BRP-01579
Molecular Formula: C42H52FN6O7P
Molecular Weight: 802.88
Purity: >95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: CCVHKDPSLDLLHS-CDTSKKGKSA-N
Solubility: Soluble in Acetonitrile, DMF
IUPAC Name: N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((diisopropylamino)(methyl)phosphaneyl)oxy)-3-fluorotetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide
InChI: InChI=1S/C42H52FN6O7P/c1-25(2)38(50)46-41-45-37-35(39(51)47-41)44-24-48(37)40-34(43)36(56-57(9)49(26(3)4)27(5)6)33(55-40)23-54-42(28-13-11-10-12-14-28,29-15-19-31(52-7)20-16-29)30-17-21-32(53-8)22-18-30/h10-22,24-27,33-34,36,40H,23H2,1-9H3,(H2,45,46,47,50,51)/t33-,34-,36-,40-,57?/m1/s1
Synonyms: N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxyguanosine-3'-methyl-phosphoramidite; 5'-O-DMTr-2'-F-dG(iBu)-3'-methyl-phosphoramidite; 2'-F dG(iBu) Me-amidite; 2'-F Guanosine (n-ibu) methyl phosphoramidite

ANA 2'-F MeC(Bz) amidite

Description: N4-Benzoyl-1-(2'-deoxy-5'-O-DMT-2'-fluoro-β-D-arabinofuranosyl)-5-methylcytosine 3'-CE phosphoramidite is utilized in the synthesis of modified oligonucleotides to enhance their stability, binding affinity, and resistance to enzymatic degradation, making it a valuable tool for developing therapeutic nucleic acids, such as antisense oligonucleotides and siRNAs, as well as for studying nucleic acid interactions and processes in biochemical research.
CAT: BRP-01580
Molecular Formula: C47H53FN5O8P
Molecular Weight: 865.94
Purity: >95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: XYPAFCMPDQWTME-MCYFHWMRSA-N
Solubility: Soluble in Acetonitrile, DMF
CanonicalSMILES: CC1=CN(C(=O)N=C1NC(=O)C2=CC=CC=C2)C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N(C(C)C)C(C)C)OCCC#N)F
IUPAC Name: N-[1-[(2R,3S,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-fluorooxolan-2-yl]-5-methyl-2-oxopyrimidin-4-yl]benzamide
InChI: InChI=1S/C47H53FN5O8P/c1-31(2)53(32(3)4)62(59-28-14-27-49)61-42-40(60-45(41(42)48)52-29-33(5)43(51-46(52)55)50-44(54)34-15-10-8-11-16-34)30-58-47(35-17-12-9-13-18-35,36-19-23-38(56-6)24-20-36)37-21-25-39(57-7)26-22-37/h8-13,15-26,29,31-32,40-42,45H,14,28,30H2,1-7H3,(H,50,51,54,55)/t40-,41+,42-,45-,62?/m1/s1
Synonyms: N4-Benzoyl-1-(2'-deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)-5-methylcytosine 3'-CE phosphoramidite; (2R,3R,4S,5R)-5-(4-benzamido-5-methyl-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

2'-F N1-Methyl PseudoUridine amidite

Description: 2'-F N1-Methyl PseudoUridine amidite is employed in the solid-phase synthesis of modified oligonucleotides. It is a powerful tool in the synthesis of stable and effective modified oligonucleotides for research and therapeutic purposes.
CAT: BRP-01581
Molecular Formula: C40H48FN4O8P
Molecular Weight: 762.82
Purity: >95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: VYDSFQVJLJFHSF-HRZVAZJQSA-N
Solubility: Soluble in Acetonitrile, DMF
IUPAC Name: (2R,3R,4S,5S)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C40H48FN4O8P/c1-26(2)45(27(3)4)54(51-23-11-22-42)53-37-34(52-36(35(37)41)33-24-44(5)39(47)43-38(33)46)25-50-40(28-12-9-8-10-13-28,29-14-18-31(48-6)19-15-29)30-16-20-32(49-7)21-17-30/h8-10,12-21,24,26-27,34-37H,11,23,25H2,1-7H3,(H,43,46,47)/t34-,35+,36+,37-,54?/m1/s1
Synonyms: N1-Me-5'-O-DMT-2'-fluoro-2'-Deoxy PseudoUridine 3'-CE phosphoramidite; 2'-F-N1-Me-pU amidite; 2'-Fluoro-N1-Me-pU-3'-phosphoramidite

2'-F C(Ac) OBn-amidite

Description: 2'-F C(Ac) OBn-amidite is a phosphoramidite reagent used in the synthesis of modified DNA oligonucleotides. It allows for the controlled synthesis of DNA oligonucleotides with modified cytidine bases. These modifications enhance the stability, functionality, and specificity of the resulting oligonucleotide, making it useful for various research and biomedical applications.
CAT: BRP-01582
Molecular Formula: C45H52FN4O8P
Molecular Weight: 826.90
Purity: >95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: SHMALCARVZQMLW-ACVVKSTRSA-N
Solubility: Soluble in Acetonitrile, DMF
IUPAC Name: (2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl benzyl diisopropylphosphoramidite
InChI: InChI=1S/C45H52FN4O8P/c1-30(2)50(31(3)4)59(56-28-33-14-10-8-11-15-33)58-42-39(57-43(41(42)46)49-27-26-40(47-32(5)51)48-44(49)52)29-55-45(34-16-12-9-13-17-34,35-18-22-37(53-6)23-19-35)36-20-24-38(54-7)25-21-36/h8-27,30-31,39,41-43H,28-29H2,1-7H3,(H,47,48,51,52)/t39-,41-,42-,43-,59?/m1/s1
Synonyms: N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxycytidine-3'-benzyloxy-phosphoramidite; 5'-O-DMTr-2'-F-dC(Ac)-3'-benzyloxy-phosphoramidite; 2'-F-Ac-dC-3'-benzyloxy-phosphoramidite; 2'-F dC(Ac) OBn-amidite; 2'-F cytidine (N-Ac) benzyloxy phosphoramidite

2'-F A(Bz) OBn-amidite

Description: 2'-F A(Bz) OBn-amidite is a phosphoramidite reagent used in the synthesis of modified DNA oligonucleotides. It enables the controlled synthesis of DNA oligonucleotides with modified adenine bases. These modifications enhance the stability, functionality, and specificity of the resulting oligonucleotide, making it valuable for various research and biomedical applications.
CAT: BRP-01583
Molecular Formula: C51H54FN6O7P
Molecular Weight: 913.00
Purity: >95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: DULYHLZNELEDNC-RLRGUIIOSA-N
Solubility: Soluble in Acetonitrile, DMF
IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl benzyl diisopropylphosphoramidite
InChI: InChI=1S/C51H54FN6O7P/c1-34(2)58(35(3)4)66(63-30-36-16-10-7-11-17-36)65-46-43(64-50(44(46)52)57-33-55-45-47(53-32-54-48(45)57)56-49(59)37-18-12-8-13-19-37)31-62-51(38-20-14-9-15-21-38,39-22-26-41(60-5)27-23-39)40-24-28-42(61-6)29-25-40/h7-29,32-35,43-44,46,50H,30-31H2,1-6H3,(H,53,54,56,59)/t43-,44-,46-,50-,66?/m1/s1
Synonyms: N6-Bz-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxyadenosine-3'-benzyloxy-phosphoramidite; 5'-O-DMTr-2'-F-dA(Bz)-3'-benzyloxy-phosphoramidite; 2'-F dA(Bz) OBn-amidite; 2'-F adenosine (N-Bz) benzyloxy phosphoramidite
* Only for research. Not suitable for any diagnostic or therapeutic use.

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