Phosphoramidites - RNA / BOC Sciences

Psoralen phosphoramidite

Description: Psoralen phosphoramidite is a compound used in nucleic acid synthesis, particularly in molecular biology and genetic research. It incorporates a psoralen derivative, a naturally occurring compound known for its ability to crosslink with nucleic acids upon exposure to ultraviolet (UV) light. This phosphoramidite form allows for the controlled addition of psoralen to oligonucleotide chains during solid-phase synthesis, enabling precise positioning within DNA or RNA strands. Psoralen phosphoramidite is valuable for applications involving the study of DNA-protein interactions, nucleic acid structure, and as a tool in various molecular biology techniques.

CAT: BRP-01438

MF: C48H55N2O9P

MF: 834.93

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InChIKey: BJYRTACQFJUEHM-UHFFFAOYSA-N

CanonicalSMILES: N#CCCOP(OC(COC(C1=CC=CC=C1)(C2=CC=C(OC)C=C2)C3=CC=C(OC)C=C3)COCC4=C(OC5=C4C=C(C(C)=C6)C(OC6=O)=C5C)C)N(C(C)C)C(C)C

IUPAC Name: 1-(bis(4-methoxyphenyl)(phenyl)methoxy)-3-((2,5,9-trimethyl-7-oxo-7H-furo[3,2-g]chromen-3-yl)methoxy)propan-2-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C48H55N2O9P/c1-31(2)50(32(3)4)60(56-25-13-24-49)59-41(28-54-30-44-35(7)57-47-34(6)46-42(27-43(44)47)33(5)26-45(51)58-46)29-55-48(36-14-11-10-12-15-36,37-16-20-39(52-8)21-17-37)38-18-22-40(53-9)23-19-38/h10-12,14-23,26-27,31-32,41H,13,25,28-30H2,1-9H3

Psoralen C-4 CED phosphoramidite

Description: Psoralen C-4 CED phosphoramidite is a specialized compound utilized in nucleic acid synthesis, particularly in molecular biology and genetic research. It likely incorporates a psoralen derivative with modification at the C-4 position, enabling controlled interactions with nucleic acids. The CED phosphoramidite moiety facilitates its incorporation into oligonucleotide chains during solid-phase synthesis, allowing for precise positioning within DNA or RNA strands. This compound is valuable for applications involving psoralen-mediated crosslinking, which is useful for studying DNA-protein interactions and nucleic acid structure.

CAT: BRP-01439

MF: C28H39N2O6P

MF: 530.59

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InChIKey: KOBCWUDIRGLRAB-UHFFFAOYSA-N

CanonicalSMILES: N#CCCOP(OCCCCOCC1=C(OC2=C1C=C(C(C)=C3)C(OC3=O)=C2C)C)N(C(C)C)C(C)C

IUPAC Name: 2-cyanoethyl (4-((2,5,9-trimethyl-7-oxo-7H-furo[3,2-g]chromen-3-yl)methoxy)butyl) diisopropylphosphoramidite

InChI: InChI=1S/C28H39N2O6P/c1-18(2)30(19(3)4)37(34-14-10-11-29)33-13-9-8-12-32-17-25-22(7)35-28-21(6)27-23(16-24(25)28)20(5)15-26(31)36-27/h15-16,18-19H,8-10,12-14,17H2,1-7H3

Synonyms: Psoralen-C4 CEP; Psoralen C4 Phosphoramidite

2'-O-Methyl-3'-DMT Cytidine (n-bz) 5'-CED phosphoramidite

Description: 2'-O-Methyl-3'-DMT 5-Methyl-Cytidine (N-Bz) 5'-CED Phosphoramidite is a specialized nucleotide compound essential in oligonucleotide synthesis. Featuring a 2'-O-methyl modification and a 3'-DMT protecting group for stability, it also incorporates a 5-methyl-cytidine base with a benzoyl (Bz) modification at the N4 position. Its 5'-CED phosphoramidite functionality enables controlled addition to oligonucleotide chains, offering versatility and precision in molecular biology research and nucleic acid design.

CAT: BRP-01450

CAS: 2101622-72-2

MF: C47H54N5O9P

MF: 863.93

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InChIKey: MCJDWFDEBMUCDZ-VKBHKTMGSA-N

CanonicalSMILES: N#CCCOP(OCC1OC(N2C=CC(=NC2=O)NC(=O)C=3C=CC=CC3)C(OC)C1OC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C

IUPAC Name: ((2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-3-(bis(4-methoxyphenyl)(phenyl)methoxy)-4-methoxytetrahydrofuran-2-yl)methyl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C47H54N5O9P/c1-32(2)52(33(3)4)62(58-30-14-28-48)59-31-40-42(43(57-7)45(60-40)51-29-27-41(50-46(51)54)49-44(53)34-15-10-8-11-16-34)61-47(35-17-12-9-13-18-35,36-19-23-38(55-5)24-20-36)37-21-25-39(56-6)26-22-37/h8-13,15-27,29,32-33,40,42-43,45H,14,30-31H2,1-7H3,(H,49,50,53,54)/t40-,42-,43-,45-,62?/m1/s1

Synonyms: Cytidine, N-benzoyl-2'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 5'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; 2'-O-Me-3'-DMT C(Bz) 5'-CE phosphoramidite; 3'-DMT-2'-OMe-C(Bz)-CE Reverse

2'-O-Methyl-3'-DMT 5-Methyl-Cytidine (n-bz) 5'-CED Phosphoramidite

Description: 2'-O-Methyl-3'-DMT Cytidine (N-Bz) 5'-CED phosphoramidite is a modified nucleotide crucial for precise oligonucleotide synthesis. It incorporates a 2'-O-methyl modification and a 3'-DMT protecting group, ensuring stability during synthesis. Additionally, the cytidine base is modified with a benzoyl (Bz) group, allowing controlled interaction at the N4 position. Its 5'-CED phosphoramidite functionality facilitates stepwise addition to oligonucleotide chains, making it indispensable in molecular biology for tailored nucleic acid design and research applications.

CAT: BRP-01451

MF: C48H56N5O9P

MF: 877.96

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InChIKey: WSOJMKBDTHLPSQ-AENBYTAOSA-N

IUPAC Name: ((2R,3R,4R,5R)-5-(4-benzamido-5-methyl-2-oxopyrimidin-1(2H)-yl)-3-(bis(4-methoxyphenyl)(phenyl)methoxy)-4-methoxytetrahydrofuran-2-yl)methyl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C48H56N5O9P/c1-32(2)53(33(3)4)63(59-29-15-28-49)60-31-41-42(43(58-8)46(61-41)52-30-34(5)44(51-47(52)55)50-45(54)35-16-11-9-12-17-35)62-48(36-18-13-10-14-19-36,37-20-24-39(56-6)25-21-37)38-22-26-40(57-7)27-23-38/h9-14,16-27,30,32-33,41-43,46H,15,29,31H2,1-8H3,(H,50,51,54,55)/t41-,42-,43-,46-,63?/m1/s1

Synonyms: 5-Methylcytidine, N-benzoyl-2'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 5'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; 2'-O-Me-3'-DMT 5-Methyl-C(Bz) 5'-CE phosphoramidite; 3'-DMT-2'-OMe-5-Methyl-C(Bz)-CE Reverse

2'-O-Methyl-3'-DMT 5-Methyl-Uridine 5'-CED Phosphoramidite

Description: 2'-O-Methyl-3'-DMT 5-Methyl-Uridine 5'-CED Phosphoramidite is a specialized nucleotide used in oligonucleotide synthesis. It is characterized by a 2'-O-methyl modification and a 3'-DMT protecting group, ensuring stability during synthesis. Additionally, the uridine base is modified with a methyl group at the 5-position. With its 5'-CED phosphoramidite functionality, this compound facilitates controlled addition to oligonucleotide chains, offering precision and versatility in molecular biology research and nucleic acid design.

CAT: BRP-01452

MF: C41H51N4O9P

MF: 774.84

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InChIKey: IUNYBTUERIDWLR-VNZAIEIISA-N

IUPAC Name: ((2R,3R,4R,5R)-3-(bis(4-methoxyphenyl)(phenyl)methoxy)-4-methoxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C41H51N4O9P/c1-27(2)45(28(3)4)55(51-24-12-23-42)52-26-35-36(37(50-8)39(53-35)44-25-29(5)38(46)43-40(44)47)54-41(30-13-10-9-11-14-30,31-15-19-33(48-6)20-16-31)32-17-21-34(49-7)22-18-32/h9-11,13-22,25,27-28,35-37,39H,12,24,26H2,1-8H3,(H,43,46,47)/t35-,36-,37-,39-,55?/m1/s1

Synonyms: 2'-O-Me-3'-DMT 5-Methyl-U 5'-CE phosphoramidite; 3'-DMT-2'-OMe-5-Methyl-U-CE Reverse

2'-tBDSilyl-3'-DMT-Uridine 5'-CED phosphoramidite

Description: 2'-tBDSilyl-3'-DMT-Uridine 5'-CED phosphoramidite is a specialized nucleotide compound utilized in oligonucleotide synthesis. It is characterized by a 2'-t-butyldimethylsilyl (TBDMS) group protecting the 2' hydroxyl, a 3'-DMT group protecting the 3' hydroxyl, and a uridine base. The 5'-CED phosphoramidite functionality enables controlled addition to oligonucleotide chains during synthesis. This compound provides stability and precise control over nucleotide addition, making it valuable in molecular biology research for designing and synthesizing custom oligonucleotides.

CAT: BRP-01453

CAS: 1146146-30-6

MF: C45H61N4O9PSi

MF: 861.05

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InChIKey: ADUXPZBKAIWXQM-ZMHKPELYSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OCC1C(C(C(O1)N2C=CC(=O)NC2=O)O[Si](C)(C)C(C)(C)C)OC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: 3-[[(2R,3R,4R,5R)-3-[bis(4-methoxyphenyl)-phenylmethoxy]-4-[tert-butyl(dimethyl)silyl]oxy-5-(2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C45H61N4O9PSi/c1-31(2)49(32(3)4)59(54-29-15-27-46)55-30-38-40(41(58-60(10,11)44(5,6)7)42(56-38)48-28-26-39(50)47-43(48)51)57-45(33-16-13-12-14-17-33,34-18-22-36(52-8)23-19-34)35-20-24-37(53-9)25-21-35/h12-14,16-26,28,31-32,38,40-42H,15,29-30H2,1-11H3,(H,47,50,51)/t38-,40-,41-,42-,59?/m1/s1

Synonyms: Uridine, 3'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 5'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; 2'-O-TBDMS-3'-DMT U 5'-CE phosphoramidite; 3'-DMT-2'-TBDMS-U-CE Reverse

2'-tBDSilyl-3'-DMT-Guanosine (N-iPr PAC) 5'-CED phosphoramidite

Description: 2'-tBDSilyl-3'-DMT-Guanosine (N-iPr PAC) 5'-CED Phosphoramidite is a specialized nucleotide used in oligonucleotide synthesis. It features a 2'-tert-butyldimethylsilyl (tBDSilyl) protecting group and a 3'-dimethoxytrityl (DMT) protecting group for stability during synthesis, with guanosine as the base modified with an isopropyl (N-iPr) phenoxyacetyl (PAC) group. Additionally, it contains a 5'-cyanoethyl (CED) phosphoramidite functionality, enabling controlled addition during synthesis. This compound facilitates stable and precise synthesis of customized oligonucleotides, essential for various molecular biology research applications.

CAT: BRP-01456

CAS: 2095378-87-1

MF: C57H74N7O10PSi

MF: 1076.30

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InChIKey: MBJRLTFVWCADRZ-WYRUHZNWSA-N

CanonicalSMILES: N#CCCOP(OCC1OC(N2C=NC=3C(=O)N=C(NC(=O)COC4=CC=C(C=C4)C(C)C)NC32)C(O[Si](C)(C)C(C)(C)C)C1OC(C=5C=CC=CC5)(C6=CC=C(OC)C=C6)C7=CC=C(OC)C=C7)N(C(C)C)C(C)C

IUPAC Name: ((2R,3R,4R,5R)-3-(bis(4-methoxyphenyl)(phenyl)methoxy)-4-((tert-butyldimethylsilyl)oxy)-5-(2-(2-(4-isopropylphenoxy)acetamido)-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-2-yl)methyl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C57H74N7O10PSi/c1-37(2)40-20-26-46(27-21-40)69-35-48(65)60-55-61-52-49(53(66)62-55)59-36-63(52)54-51(74-76(12,13)56(7,8)9)50(47(72-54)34-71-75(70-33-17-32-58)64(38(3)4)39(5)6)73-57(41-18-15-14-16-19-41,42-22-28-44(67-10)29-23-42)43-24-30-45(68-11)31-25-43/h14-16,18-31,36-39,47,50-51,54H,17,33-35H2,1-13H3,(H2,60,61,62,65,66)/t47-,50-,51-,54-,75?/m1/s1

Synonyms: 3'-O-DMTr-2'-O-TBDMS-G(iPr-PAC)-5'-CE-Phosphoramidite; 3'-DMT-2'-TBDMS-G(iPr-PAC)-CE Reverse

2'-tBDSilyl-3'-DMT-Adenosine (n-bz) 5'-CED phosphoramidite

Description: 2'-tBDSilyl-3'-DMT-Adenosine (n-bz) 5'-CED phosphoramidite is a specialized nucleotide compound used in oligonucleotide synthesis. It features a 2'-t-butyldimethylsilyl (TBDMS) group protecting the 2' hydroxyl, a 3'-DMT group protecting the 3' hydroxyl, and an adenosine base with a benzoyl (Bz) modification. The 5'-CED phosphoramidite functionality enables controlled addition to oligonucleotide chains during synthesis. This compound offers stability and precise control over nucleotide addition, making it valuable in molecular biology research for custom oligonucleotide design and synthesis.

CAT: BRP-01457

CAS: 1146146-22-6

MF: C53H66N7O8PSi

MF: 988.19

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InChIKey: LKKBOWOULSPXLM-RFMFGJHUSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OCC1C(C(C(O1)N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)O[Si](C)(C)C(C)(C)C)OC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC

IUPAC Name: N-[9-[(2R,3R,4R,5R)-4-[bis(4-methoxyphenyl)-phenylmethoxy]-3-[tert-butyl(dimethyl)silyl]oxy-5-[[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxymethyl]oxolan-2-yl]purin-6-yl]benzamide

InChI: InChI=1S/C53H66N7O8PSi/c1-36(2)60(37(3)4)69(64-32-18-31-54)65-33-44-46(67-53(39-21-16-13-17-22-39,40-23-27-42(62-8)28-24-40)41-25-29-43(63-9)30-26-41)47(68-70(10,11)52(5,6)7)51(66-44)59-35-57-45-48(55-34-56-49(45)59)58-50(61)38-19-14-12-15-20-38/h12-17,19-30,34-37,44,46-47,51H,18,32-33H2,1-11H3,(H,55,56,58,61)/t44-,46-,47-,51-,69?/m1/s1

Synonyms: ((2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-3-(bis(4-methoxyphenyl)(phenyl)methoxy)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-2-yl)methyl (2-cyanoethyl) diisopropylphosphoramidite; Adenosine, N-benzoyl-3'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 5'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; 3'-O-DMTr-2'-O-TBDMS-A(Bz)-5'-CE-Phosphoramidite; 3'-DMT-2'-TBDMS-A(Bz)-CE Reverse

2'-tBDSilyl-3'-DMT-Cytidine (n-acetyl) 5'-CED phosphoramidite

Description: 2'-tBDSilyl-3'-DMT-Cytidine (N-acetyl) 5'-CED phosphoramidite is a specialized nucleotide compound utilized in oligonucleotide synthesis. It consists of a 2'-tert-butyldimethylsilyl (tBDSilyl) protecting group and a 3'-dimethoxytrityl (DMT) protecting group for stability during synthesis, with cytidine as the base modified with an acetyl (N-acetyl) group. Additionally, it features a 5'-CED (5'-cyanoethyl) phosphoramidite functionality, allowing controlled addition during synthesis. This compound enables precise and stable synthesis of custom oligonucleotides, essential for various molecular biology research applications.

CAT: BRP-01459

CAS: 1146146-25-9

MF: C47H64N5O9PSi

MF: 902.10

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InChIKey: GNFNITVIZVVSKA-YOEDQOPESA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OCC1C(C(C(O1)N2C=CC(=NC2=O)NC(=O)C)O[Si](C)(C)C(C)(C)C)OC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: N-[1-[(2R,3R,4R,5R)-4-[bis(4-methoxyphenyl)-phenylmethoxy]-3-[tert-butyl(dimethyl)silyl]oxy-5-[[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxymethyl]oxolan-2-yl]-2-oxopyrimidin-4-yl]acetamide

InChI: InChI=1S/C47H64N5O9PSi/c1-32(2)52(33(3)4)62(57-30-16-28-48)58-31-40-42(43(61-63(11,12)46(6,7)8)44(59-40)51-29-27-41(49-34(5)53)50-45(51)54)60-47(35-17-14-13-15-18-35,36-19-23-38(55-9)24-20-36)37-21-25-39(56-10)26-22-37/h13-15,17-27,29,32-33,40,42-44H,16,30-31H2,1-12H3,(H,49,50,53,54)/t40-,42-,43-,44-,62?/m1/s1

Synonyms: 3'-O-DMTr-2'-O-TBDMS-C(Ac)-5'-CE-Phosphoramidite; 3'-DMT-2'-TBDMS-C(Ac)-CE Reverse; Cytidine, N-acetyl-3'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 5'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

DMT-butane-Diol phosphoramidite

Description: DMT-butane-Diol phosphoramidite is a compound utilized in oligonucleotide synthesis and phosphoramidite chemistry. It acts as a phosphitylating reagent for introducing nucleotide phosphoramidites onto solid supports during the synthesis of oligonucleotides. This compound features a butyl chain with a bis(4-methoxyphenyl)(phenyl)methoxy group attached, along with a 2-cyanoethyl group and diisopropylamidophosphite functionality. Its role in oligonucleotide synthesis involves controlled addition to the growing oligonucleotide chain, enabling precise sequence design and customization for various molecular biology applications.

CAT: BRP-01464

CAS: 225786-84-5

MF: C34H45N2O5P

MF: 592.71

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InChIKey: IEDMPIUZZYENNJ-UHFFFAOYSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCCCOC(C1=CC=CC=C1)(C2=CC=C(C=C2)OC)C3=CC=C(C=C3)OC)OCCC#N

IUPAC Name: 3-[4-[bis(4-methoxyphenyl)-phenylmethoxy]butoxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C34H45N2O5P/c1-27(2)36(28(3)4)42(41-26-12-23-35)40-25-11-10-24-39-34(29-13-8-7-9-14-29,30-15-19-32(37-5)20-16-30)31-17-21-33(38-6)22-18-31/h7-9,13-22,27-28H,10-12,24-26H2,1-6H3

Synonyms: 4-[Bis(4-methoxyphenyl)(phenyl)methoxy]butyl 2-cyanoethyl diisopropylamidophosphite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 4-[bis(4-methoxyphenyl)phenylmethoxy]butyl 2-cyanoethyl ester; 4-[Bis(4-methoxyphenyl)phenylmethoxy]butyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, 4-[bis(4-methoxyphenyl)phenylmethoxy]butyl 2-cyanoethyl ester

Polyethyleneglycol 4500 CED phosphoramidite

Description: Polyethyleneglycol 4500 CED phosphoramidite is a specialized compound utilized in oligonucleotide synthesis. It consists of a polyethylene glycol (PEG) chain with a molecular weight of 4500 Da, modified with a 5'-cyanoethyl (CED) phosphoramidite functionality. This compound serves as a linker or spacer molecule, aiding in the conjugation or attachment of oligonucleotides to various biomolecules or surfaces. The PEG chain offers flexibility and water solubility, while the CED phosphoramidite allows controlled addition during synthesis, facilitating the synthesis of PEGylated oligonucleotides for various biomedical and biotechnological applications, such as drug delivery systems or diagnostics.

CAT: BRP-01465

MF: 4500.52

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Polyethyleneglycol 2000 CED phosphoramidite

Description: Polyethyleneglycol 2000 CED phosphoramidite is a specialized compound used in oligonucleotide synthesis. It consists of a polyethylene glycol (PEG) chain with a molecular weight of 2000 Da, modified with a 5'-cyanoethyl (CED) phosphoramidite functionality. This compound serves as a linker or spacer molecule, aiding in the conjugation or attachment of oligonucleotides to various biomolecules or surfaces. The PEG chain provides flexibility and water solubility, while the CED phosphoramidite allows controlled addition during synthesis, facilitating the synthesis of PEGylated oligonucleotides for various biomedical and biotechnological applications, such as drug delivery systems or diagnostics.

CAT: BRP-01466

MF: C120H217N2O49P

MF: 2502.96

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DMT-nonane-Diol phosphoramidite

Description: DMT-nonane-Diol phosphoramidite is a specialized compound used in oligonucleotide synthesis. It serves as a phosphitylating reagent for introducing nucleotide phosphoramidites onto solid supports during oligonucleotide assembly. This compound features a nonyl chain with a bis(4-methoxyphenyl)(phenyl)methoxy group attached, along with a 2-cyanoethyl group and diisopropylphosphoramidite functionality. Its role in oligonucleotide synthesis involves controlled addition to the growing oligonucleotide chain, allowing for precise sequence design and customization for various molecular biology applications.

CAT: BRP-01467

CAS: 146669-12-7

MF: C39H55N2O5P

MF: 662.84

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InChIKey: HOMIPIQVKUJKAJ-UHFFFAOYSA-N

CanonicalSMILES: N#CCCOP(OCCCCCCCCCOC(C=1C=CC=CC1)(C2=CC=C(OC)C=C2)C3=CC=C(OC)C=C3)N(C(C)C)C(C)C

IUPAC Name: 9-(bis(4-methoxyphenyl)(phenyl)methoxy)nonyl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C39H55N2O5P/c1-32(2)41(33(3)4)47(46-31-17-28-40)45-30-16-11-9-7-8-10-15-29-44-39(34-18-13-12-14-19-34,35-20-24-37(42-5)25-21-35)36-22-26-38(43-6)27-23-36/h12-14,18-27,32-33H,7-11,15-17,29-31H2,1-6H3

Synonyms: Spacer C9 CEP; Phosphoramidous acid, bis(1-methylethyl)-, 9-[bis(4-methoxyphenyl)phenylmethoxy]nonyl 2-cyanoethyl ester

5-Tamra CED Phosphoramidite

Description: 5-TAMRA CED phosphoramidite is a specialized compound employed in oligonucleotide synthesis, particularly for labeling nucleic acids. TAMRA (5-carboxytetramethylrhodamine) is a commonly used fluorescent dye that is conjugated to the 5' end of oligonucleotides for various applications such as fluorescence resonance energy transfer (FRET), fluorescence in situ hybridization (FISH), and real-time PCR. The CED (5'-cyanoethyl) phosphoramidite moiety enables controlled addition of the TAMRA-labeled nucleotide during oligonucleotide synthesis, allowing for precise customization and synthesis of labeled oligonucleotides for molecular biology and biotechnology research purposes.

CAT: BRP-01468

CAS: 321862-13-9

MF: C39H48N5O6P

MF: 713.82

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InChIKey: UVLQWZNHBVWNDP-UHFFFAOYSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1CCN(CC1)C(=O)C2=CC3=C(C=C2)C4(C5=C(C=C(C=C5)N(C)C)OC6=C4C=CC(=C6)N(C)C)OC3=O

IUPAC Name: 3-[[1-[3',6'-bis(dimethylamino)-3-oxospiro[2-benzofuran-1,9'-xanthene]-5-carbonyl]piperidin-4-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C39H48N5O6P/c1-25(2)44(26(3)4)51(47-21-9-18-40)50-30-16-19-43(20-17-30)37(45)27-10-13-32-31(22-27)38(46)49-39(32)33-14-11-28(41(5)6)23-35(33)48-36-24-29(42(7)8)12-15-34(36)39/h10-15,22-26,30H,9,16-17,19-21H2,1-8H3

Synonyms: Phosphoramidous acid, bis(1-methylethyl)-, 1-[[3',6'-bis(dimethylamino)-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl]carbonyl]-4-piperidinyl 2-cyanoethyl ester; 1-(3',6'-bis(dimethylamino)-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-5-carbonyl)piperidin-4-yl (2-cyanoethyl) diisopropylphosphoramidite

2'-tBDSilyl Guanosine (n-PAC) CED phosphoramidite

Description: 2'-tBDSilyl Guanosine (N-PAC) CED phosphoramidite is a specialized nucleotide compound used in oligonucleotide synthesis. It consists of a guanosine nucleoside modified with a 2'-tert-butyldimethylsilyl (tBDSilyl) group to protect the 2'-hydroxyl position. Additionally, it features a phenoxyacetyl (PAC) group attached to the amine group of the guanosine base. Furthermore, it contains a 5'-cyanoethyl (CED) phosphoramidite functionality, enabling controlled addition during oligonucleotide synthesis. This compound facilitates stable and precise synthesis of customized oligonucleotides, crucial for various molecular biology research applications such as PCR, sequencing, and gene expression analysis.

CAT: BRP-01475

CAS: 121058-87-5

MF: C54H68N7O10PSi

MF: 1034.22

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InChIKey: ZLYPAAZEPOYAIC-SNJLMQCASA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C(=O)N=C(NC(=O)COC=4C=CC=CC4)NC32)C1O[Si](C)(C)C(C)(C)C)COC(C=5C=CC=CC5)(C6=CC=C(OC)C=C6)C7=CC=C(OC)C=C7)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(6-oxo-2-(2-phenoxyacetamido)-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C54H68N7O10PSi/c1-36(2)61(37(3)4)72(68-32-18-31-55)70-47-44(33-67-54(38-19-14-12-15-20-38,39-23-27-41(64-8)28-24-39)40-25-29-42(65-9)30-26-40)69-51(48(47)71-73(10,11)53(5,6)7)60-35-56-46-49(60)58-52(59-50(46)63)57-45(62)34-66-43-21-16-13-17-22-43/h12-17,19-30,35-37,44,47-48,51H,18,32-34H2,1-11H3,(H2,57,58,59,62,63)/t44-,47-,48-,51-,72?/m1/s1

Synonyms: Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-N-(phenoxyacetyl)-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; 2'-TBDMS G(PAC) 3'-CE phosphoramidite

5'-O-DMT-2'-O-TBDMS-5-Formyl-N4-(4-Methoxybenzoyl)-Cytidine-3'-CE Phosphoramidite

Description: 5'-O-DMT-2'-O-TBDMS-5-Formyl-N4-(4-Methoxybenzoyl)-Cytidine-3'-CE Phosphoramidite is a chemically modified nucleoside used in the synthesis of oligonucleotides. These modifications protect the nucleoside during synthesis and can be selectively removed to yield the desired oligonucleotide.

CAT: BRP-01498

MF: C57H74N5O12PSi

MF: 1080.29

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InChIKey: YFOBMYILHRTVRW-GIMIVTJESA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=C(C(=NC2=O)NC(=O)C3=CC=C(OC)C=C3)C4OCCCO4)C1O[Si](C)(C)C(C)(C)C)COC(C=5C=CC=CC5)(C6=CC=C(OC)C=C6)C7=CC=C(OC)C=C7)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-5-(5-(1,3-dioxan-2-yl)-4-(4-methoxybenzamido)-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C57H74N5O12PSi/c1-38(2)62(39(3)4)75(71-35-16-32-58)73-49-48(37-70-57(41-18-14-13-15-19-41,42-22-28-45(66-9)29-23-42)43-24-30-46(67-10)31-25-43)72-53(50(49)74-76(11,12)56(5,6)7)61-36-47(54-68-33-17-34-69-54)51(60-55(61)64)59-52(63)40-20-26-44(65-8)27-21-40/h13-15,18-31,36,38-39,48-50,53-54H,16-17,33-35,37H2,1-12H3,(H,59,60,63,64)/t48-,49-,50-,53-,75?/m1/s1

Synonyms: 5-Formyl-N4-(4-Methoxybenzoyl)-rC phosphoramidite

Related CAS: 2143457-28-5 (R-isomer) ; 143457-29-6 (S-isomer)

DMT-2'-O-Methyl-rC(tac) Phosphoramidite (BRP-01499)

Description: DMT-2'-O-Methyl-rC(tac) Phosphoramidite is a modified phosphoramidite designed for the synthesis of stable and efficient RNA oligonucleotides. The protective groups and modifications, such as 5'-O-DMTr and 2'-O-methyl, enhance the stability of the resulting nucleic acids and facilitate their incorporation into nucleic acid chains during solid-phase synthesis. This compound is crucial in producing antisense oligonucleotides, siRNA, probes, and primers, providing enhanced resistance to enzymatic degradation and improved performance in various applications.

CAT: BRP-01499

MF: C52H64N5O10P

MF: 950.08

Purity: ≥95% by HPLC

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Storage: Store at 2-8 °C

InChIKey: JRJMGDLRRSEUHM-MVHRPHEDSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OC)N2C=CC(=NC2=O)NC(=O)COC3=CC=C(C=C3)C(C)(C)C)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-methoxyoxolan-2-yl]-2-oxopyrimidin-4-yl]-2-(4-tert-butylphenoxy)acetamide

InChI: InChI=1S/C52H64N5O10P/c1-35(2)57(36(3)4)68(65-32-14-30-53)67-47-44(33-64-52(38-15-12-11-13-16-38,39-19-23-41(60-8)24-20-39)40-21-25-42(61-9)26-22-40)66-49(48(47)62-10)56-31-29-45(55-50(56)59)54-46(58)34-63-43-27-17-37(18-28-43)51(5,6)7/h11-13,15-29,31,35-36,44,47-49H,14,32-34H2,1-10H3,(H,54,55,58,59)/t44-,47-,48-,49-,68?/m1/s1

Synonyms: 2'-OMe-rC(TAc) CE phosphoramidite; 5'-O-(4,4-Dimethoxytrityl)-N-[[4-(tert-butyl)phenoxy]acetyl]-2'-O-methylcytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite; DMT-2'O-Methyl-rC(tac) Phosphoramidite; DMT-2'-O-Me-rC(tac) amidite; 2'-O-Methyl-rC(N-tac)Phosphoramidite; 5'-O-DMT-N4-[(4-i-propylphenoxy)acetyl]-2'-O-methylcytidine 3'-CE phosphoramidite; DMT-2'O-Methyl-rC(tac) Phosphoramidite

Related CAS: 179486-26-1 (R-isomer) ; 179486-27-2 (S-isomer)

[5'-O-DMTr-2'-OMe-C(Ac)](pCyEt)[2'-F-dG(iBu)-3'-CE-Phosphoramidite]

Description: [5'-O-DMTr-2'-OMe-C(Ac)](pCyEt)[2'-F-dG(iBu)-3'-CE-Phosphoramidite] is a specialized building block for synthesizing chemically modified oligonucleotides. These modifications improve the properties of nucleic acids for research and therapeutic purposes, such as increased stability, specificity, and resistance to degradation. This compound is crucial in the fields of biochemical research and therapeutic development, contributing to advancements in genetic and molecular medicine.

CAT: BRP-01504

MF: C59H72FN11O16P2

MF: 1272.21

Purity: ≥97% by HPLC

Appearance: White, off-white to faint yellow powder

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Storage: Store at -20 °C

InChIKey: LTNXRWAXHVYTRJ-FVZAZZLTSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((((((2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-4-fluoro-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C59H72FN11O16P2/c1-35(2)53(73)67-57-66-52-48(54(74)68-57)63-34-70(52)55-47(60)49(86-88(81-30-14-27-61)71(36(3)4)37(5)6)45(84-55)33-83-89(76,82-31-15-28-62)87-50-44(85-56(51(50)79-10)69-29-26-46(64-38(7)72)65-58(69)75)32-80-59(39-16-12-11-13-17-39,40-18-22-42(77-8)23-19-40)41-20-24-43(78-9)25-21-41/h11-13,16-26,29,34-37,44-45,47,49-51,55-56H,14-15,30-33H2,1-10H3,(H,64,65,72,75)(H2,66,67,68,73,74)/t44-,45-,47-,49-,50-,51-,55-,56-,88?,89?/m1/s1

Synonyms: [5'-O-DMTr-2'-OMe-C(Ac)](pCyEt)[2'-F-G(ibu)-3'-CE-Phosphoramidite]; CmGf; [5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-C(acetyl)](pCyEt)[2'-Fluoro-dG(isobutyryl)-3'-cyanoethyl-Phosphoramidite]

[5'-O-DMTr-2'-OMe-U](pCyEt)[2'-F-dA(Bz)-3'-CE-Phosphoramidite]

Description: [5'-O-DMTr-2'-OMe-U](pCyEt)[2'-F-dA(Bz)-3'-CE-Phosphoramidite] is a modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of a 5'-O-DMTr-2'-OMe-uridine, coupled with a 2'-fluoro-deoxyadenosine (2'-F-dA) featuring a benzoyl (Bz) protecting group. These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making it valuable for biochemical research and therapeutic applications.

CAT: BRP-01505

MF: C60H67FN10O15P2

MF: 1249.20

Purity: ≥97% by HPLC

Appearance: White, off-white to faint yellow powder

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Storage: Store at -20 °C

InChIKey: FFDBGFAJQMQYDB-YJAGKEHNSA-N

IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C60H67FN10O15P2/c1-38(2)71(39(3)4)87(80-32-14-29-62)85-51-47(83-57(49(51)61)70-37-66-50-54(64-36-65-55(50)70)68-56(73)40-16-10-8-11-17-40)35-82-88(75,81-33-15-30-63)86-52-46(84-58(53(52)78-7)69-31-28-48(72)67-59(69)74)34-79-60(41-18-12-9-13-19-41,42-20-24-44(76-5)25-21-42)43-22-26-45(77-6)27-23-43/h8-13,16-28,31,36-39,46-47,49,51-53,57-58H,14-15,32-35H2,1-7H3,(H,67,72,74)(H,64,65,68,73)/t46-,47-,49-,51-,52-,53-,57-,58-,87?,88?/m1/s1

Synonyms: [5'-O-(4,4'-dimethoxytrityl)-2'-O-methyluridine](pCyEt)[2'-Fluoro-deoxy-A(benzoyl)-3'-cyanoethyl-Phosphoramidite]; UmAf; [5'-O-DMTr-2'-OMe-U](pCyEt)[2'-F-A(Bz)-3'-CE Phosphoramidite]

[5'-O-DMTr-2'-OMe-C(Ac)](pCyEt)[2'-F-dU-3'-CE-Phosphoramidite]

Description: [5'-O-DMTr-2'-OMe-C(Ac)](pCyEt)[2'-F-dU-3'-CE-Phosphoramidite] is a modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of a 5'-O-DMTr-2'-OMe-cytidine with an acetyl (Ac) protecting group, coupled with a 2'-fluoro-deoxyuridine (2'-F-dU). These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making it valuable for biochemical research and therapeutic applications.

CAT: BRP-01506

MF: C54H65FN8O16P2

MF: 1163.10

Purity: ≥97% by HPLC

Appearance: White, off-white to faint yellow powder

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Storage: Store at -20 °C

InChIKey: KDSLXRMSXDHYPC-JFJKBCMNSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((((((2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C54H65FN8O16P2/c1-34(2)63(35(3)4)80(73-30-12-26-56)78-47-43(76-50(46(47)55)61-29-25-45(65)60-53(61)67)33-75-81(68,74-31-13-27-57)79-48-42(77-51(49(48)71-8)62-28-24-44(58-36(5)64)59-52(62)66)32-72-54(37-14-10-9-11-15-37,38-16-20-40(69-6)21-17-38)39-18-22-41(70-7)23-19-39/h9-11,14-25,28-29,34-35,42-43,46-51H,12-13,30-33H2,1-8H3,(H,60,65,67)(H,58,59,64,66)/t42-,43-,46-,47-,48-,49-,50-,51-,80?,81?/m1/s1

Synonyms: [5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-C(acetyl)](pCyEt)[2'-O-Me-U-3'-cyanoethyl-Phosphoramidite]; CmUf; [5'-O-DMTr-2'-OMe C(Ac)](pCyEt)[2'-F-U-3'-CE Phosphoramidite]