Phosphoramidites

2'-Modified Phosphoramidites
(529/529)
2'-Phosphoramidites
(27/27)
3'-Modified Phosphoramidites
(201/201)
5'-Modified Phosphoramidites
(30/30)
Arabino Phosphoramidites
(23/23)
Base Protected Phosphoramidites (418/418) Dye Phosphoramidites
(53/53)
Label Phosphoramidites
(82/82)
Linker Phosphoramidites
(85/85)
Other Phosphoramidites
(97/97)
PMO Phosphoramidates and Derivatives (33/33) PseudoUridine Phosphoramidite
(12/12)
Reverse Phosphoramidites
(25/25)
Spacer Phosphoramidites
(24/24)
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5'-ODMT cEt N-Bz C Phosphoramidite (Amidite)

Description: 5'-ODMT cEt N-Bz C Phosphoramidite (Amidite) is a specialized chemical reagent used in the synthesis of modified oligonucleotides. This compound features a cytosine (C) base with an N4-benzoyl (N-Bz) protecting group and a constrained ethyl (cEt) modification, along with a 5'-O-(4,4'-dimethoxytrityl) (DMT) protective group. The constrained ethyl (cEt) modification enhances the stability and binding affinity of the resulting oligonucleotide. This modification increases resistance to nuclease degradation and improves hybridization properties, which is crucial for various research and therapeutic applications. 5'-ODMT cEt N-Bz C Phosphoramidite (Amidite) is an essential reagent for synthesizing modified oligonucleotides, providing enhanced stability, binding affinity, and resistance to degradation, particularly useful in developing advanced nucleic acid-based therapeutics and research tools.
CAT: BRP-01530
CAS: 945628-57-9
Molecular Formula: C48H54N5O9P
Molecular Weight: 875.94
Purity: ≥98% by HPLC
Appearance: White to off-white solid
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Storage: Store at -20 °C, stored under nitrogen, away from moisture
InChIKey: QLEUKMYYYZVVED-INXIQYKVSA-N
Solubility: Soluble in DMSO
CanonicalSMILES: CC1C2(C(C(O1)C(O2)N3C=CC(=NC3=O)NC(=O)C4=CC=CC=C4)OP(N(C(C)C)C(C)C)OCCC#N)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC
IUPAC Name: N-[1-[(1S,3R,4R,6S,7S)-1-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-7-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-6-methyl-2,5-dioxabicyclo[2.2.1]heptan-3-yl]-2-oxopyrimidin-4-yl]benzamide
InChI: InChI=1S/C48H54N5O9P/c1-32(2)53(33(3)4)63(59-30-14-28-49)62-43-42-45(52-29-27-41(51-46(52)55)50-44(54)35-15-10-8-11-16-35)61-47(43,34(5)60-42)31-58-48(36-17-12-9-13-18-36,37-19-23-39(56-6)24-20-37)38-21-25-40(57-7)26-22-38/h8-13,15-27,29,32-34,42-43,45H,14,30-31H2,1-7H3,(H,50,51,54,55)/t34-,42+,43-,45+,47-,63?/m0/s1
Synonyms: S-cEt-C phosphoramidite; 5'-ODMT cEt N-Bz C Phosphoramidite; 5'-ODMT cEt C(Bz) Phosphoramidite; N4-Bz-2'-O-4'-A-Locked-Cr-CET-Phosphoramidite; CET-C(Bz) Phosphoramidite; 5'-ODMT cEt N-Bz C Phosphoramidite Amidite; S-cEt-C(Bz)-CE-Phosphoramidite; N-[1-[2,5-Anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-6-deoxy-α-L-mannofuranosyl]-1,2-dihydro-2-oxo-4-pyrimidinyl]benzamide

DMT-2'-F-dG(DMF)-CE-Phosphoramidite

Description: DMT-2'-F-dG(DMF)-CE-Phosphoramidite is a chemically modified phosphoramidite utilized in the solid-phase synthesis of oligonucleotides. The modifications, including the fluorine at the 2' position and the protecting groups, enhance the stability and specificity of the synthesized oligonucleotides. These modifications can be critical for applications in genetic research, diagnostics, and the development of antisense oligonucleotides, siRNA, and other nucleic acid-based therapeutics. The fluorine substitution particularly contributes to increased resistance against enzymatic degradation, making the oligonucleotides more durable and effective in biological systems.
CAT: BRP-01539
Molecular Formula: C43H52FN8O7P
Molecular Weight: 842.91
Purity: ≥98%
Appearance: White solid
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Storage: Store at -20 °C
InChIKey: BUKKJOTXODUNQK-PKTARBJSSA-N
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1F)N2C=NC3=C2N=C(NC3=O)N=CN(C)C)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC
IUPAC Name: N'-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-fluorooxolan-2-yl]-6-oxo-1H-purin-2-yl]-N,N-dimethylmethanimidamide
InChI: InChI=1S/C43H52FN8O7P/c1-28(2)52(29(3)4)60(57-24-12-23-45)59-38-35(58-41(36(38)44)51-27-46-37-39(51)48-42(49-40(37)53)47-26-50(5)6)25-56-43(30-13-10-9-11-14-30,31-15-19-33(54-7)20-16-31)32-17-21-34(55-8)22-18-32/h9-11,13-22,26-29,35-36,38,41H,12,24-25H2,1-8H3,(H,48,49,53)/t35-,36-,38-,41-,60?/m1/s1
Synonyms: 2'-F G(dmf) amidite; 2'-Fluoro-2'-deoxy Guanosine (N,N-DMF) CED Phosphoramidite; (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-(((dimethylamino)methylene)amino)-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
Related CAS: 1391913-24-8 (N'-[9-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-deoxy-2-fluoro-β-D-arabinofuranosyl]-6,9-dihydro-6-oxo-1H-purin-2-yl]-N,N-dimethylmethanimidamide)

5-Me-5'-O-DMT-N4-Acetyl-2'-fluoro-2'-deoxy-cytidine 3'-CE phosphoramidite

Description: 5-Me-5'-O-DMT-N4-Acetyl-2'-fluoro-2'-deoxy-cytidine 3'-CE phosphoramidite is used in the synthesis of modified oligonucleotides to enhance their stability, specificity, and resistance to enzymatic degradation, making it valuable for developing therapeutic agents such as antisense oligonucleotides and siRNAs, as well as for studying nucleic acid interactions and enzymatic processes in research.
CAT: BRP-01540
Molecular Formula: C42H51FN5O8P
Molecular Weight: 803.87
Purity: >98%
Appearance: White to off-white powder
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Storage: Store at -20 °C
InChIKey: XKIOEQRURPSLHT-FNZMFDOGSA-N
Solubility: Soluble in Acetonitrile, DMF
IUPAC Name: (2R,3R,4R,5R)-5-(4-acetamido-5-methyl-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C42H51FN5O8P/c1-27(2)48(28(3)4)57(54-24-12-23-44)56-38-36(55-40(37(38)43)47-25-29(5)39(45-30(6)49)46-41(47)50)26-53-42(31-13-10-9-11-14-31,32-15-19-34(51-7)20-16-32)33-17-21-35(52-8)22-18-33/h9-11,13-22,25,27-28,36-38,40H,12,24,26H2,1-8H3,(H,45,46,49,50)/t36-,37-,38-,40-,57?/m1/s1
Synonyms: 2'-F MeC(Ac) amidite; N4-Acetyl-2'-deoxy-5'-O-DMT-2'-fluoro-5-methylcytidine 3'-CE phosphoramidite; 2'-Fluoro-5MeC(Ac)-3'-phosphoramidite; 5-Me-N4-Ac-5'-O-DMT-2'-fluoro-2'-deoxy-cytidine 3'-CE phosphoramidite; N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-fluoro-5-methylcytidine-3'-O-[(2-cyanoethyl)(N,N-diisopropyl)]phosphoramidite; N4-Ac-5'-O-DMTr-2'-deoxy-2'-fluoro-5-methylcytidine-3'-CED phosphoramidite; N-Acetyl-2'-deoxy-5'-O-DMT-2'-fluoro-5-methylcytidine 3'-CE phosphoramidite; DMT-2'-F-dC(Ac)-CE-Phosphoramidite

5'-O-(4,4'-Dimethoxytrityl)-2'-trifluoroacetamido-2'-deoxyuridine-3'-cyanoethyl-phosphoramidite

Description: 5'-O-(4,4'-Dimethoxytrityl)-2'-trifluoroacetamido-2'-deoxyuridine-3'-cyanoethyl-phosphoramidite is a phosphoramidite reagent used in the automated synthesis of modified oligonucleotides. This reagent includes a 5'-dimethoxytrityl (DMTr) protecting group for the 5' hydroxyl group, a trifluoroacetamido group at the 2' position for increased stability and resistance to enzymatic degradation, uridine as the nucleobase, and a cyanoethyl (CE) phosphoramidite group at the 3' position for efficient nucleotide addition during synthesis. It is employed to create oligonucleotides with enhanced stability and specificity, making it valuable for therapeutic applications like antisense oligonucleotides and siRNAs, as well as for researching nucleic acid interactions and enzymatic processes.
CAT: BRP-01542
CAS: 126139-44-4
Molecular Formula: C41H47F3N5O9P
Molecular Weight: 841.82
Purity: ≥97% by UPLC
Appearance: White or off-white to light yellow powder
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Storage: Store at -20 °C
Melting Point: 240-243 °C
InChIKey: SSRAEXJTISFPEB-WEYVJJSGSA-N
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1NC(=O)C(F)(F)F)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC
IUPAC Name: N-[(2R,3R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-2-(2,4-dioxopyrimidin-1-yl)oxolan-3-yl]-2,2,2-trifluoroacetamide
InChI: InChI=1S/C41H47F3N5O9P/c1-26(2)49(27(3)4)59(56-24-10-22-45)58-36-33(57-37(35(36)47-38(51)41(42,43)44)48-23-21-34(50)46-39(48)52)25-55-40(28-11-8-7-9-12-28,29-13-17-31(53-5)18-14-29)30-15-19-32(54-6)20-16-30/h7-9,11-21,23,26-27,33,35-37H,10,24-25H2,1-6H3,(H,47,51)(H,46,50,52)/t33-,35-,36-,37-,59?/m1/s1
Synonyms: 5'-O-DMTr-2'-Trifluoroacetamido-U-3'-CE-Phosphoramidite; 2'-Deoxy-2'-(N-trifluoroacetyl)amino-5'-O-DMTr-uridine 3'-CED phosphoramidite; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-[(2,2,2-trifluoroacetyl)amino]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; 2'-Amino(TFA) U amidite

N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-trifluoroacetamido-2'-deoxycytidine-3'-cyanoethyl-phosphoramidite

Description: N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-trifluoroacetamido-2'-deoxycytidine-3'-cyanoethyl-phosphoramidite is a phosphoramidite reagent used in the automated chemical synthesis of modified oligonucleotides. This compound features a 5'-dimethoxytrityl (DMTr) protecting group, a trifluoroacetamido group at the 2' position for enhanced stability and resistance to enzymatic degradation, an acetyl-protected cytosine base, and a cyanoethyl (CE) phosphoramidite group at the 3' position, facilitating the stepwise addition of nucleotides. This reagent is essential for synthesizing oligonucleotides with improved stability and specificity for therapeutic applications, such as antisense oligonucleotides and siRNAs, as well as for advanced research in nucleic acid interactions and enzymatic processes.
CAT: BRP-01543
Molecular Formula: C43H50F3N6O9P
Molecular Weight: 882.88
Purity: ≥97% by UPLC
Appearance: White or off-white to light yellow powder
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Storage: Store at -20 °C
InChIKey: YKZVUVJTYKUQET-BVGHISPXSA-N
IUPAC Name: (2R,3S,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2,2,2-trifluoroacetamido)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C43H50F3N6O9P/c1-27(2)52(28(3)4)62(59-25-11-23-47)61-38-35(60-39(37(38)50-40(54)43(44,45)46)51-24-22-36(48-29(5)53)49-41(51)55)26-58-42(30-12-9-8-10-13-30,31-14-18-33(56-6)19-15-31)32-16-20-34(57-7)21-17-32/h8-10,12-22,24,27-28,35,37-39H,11,25-26H2,1-7H3,(H,50,54)(H,48,49,53,55)/t35-,37-,38-,39-,62?/m1/s1
Synonyms: 5'-O-DMTr-2'-Trifluoroacetamido-C(Ac)-3'-CE-Phosphoramidite; Cytidine, N-Acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-[(trifluoroacetyl)amino]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; 2'-Amino(TFA) C(Ac) amidite

N4-Benzoyl-5'-O-(4,4'-Dimethoxytrityl)-2'-trifluoroacetamido-2'-deoxycytidine-3'-cyanoethyl phosphoramidite

Description: N4-Benzoyl-5'-O-(4, 4'-dimethoxytrityl)-2'-trifluoroacetamido-2'-deoxycytidine-3'-cyanoethyl phosphoramidite is a phosphoramidite reagent used in the automated synthesis of modified oligonucleotides. This compound features a 5'-dimethoxytrityl (DMTr) protecting group for the 5' hydroxyl group, a trifluoroacetamido group at the 2' position to enhance stability and resistance to enzymatic degradation, a benzoyl-protected cytosine base (C(Bz)), and a cyanoethyl (CE) phosphoramidite group at the 3' position for efficient nucleotide addition during synthesis. This reagent is used to create oligonucleotides with improved stability and specificity, which are valuable for therapeutic applications such as antisense oligonucleotides and siRNAs, as well as for studying nucleic acid interactions and enzymatic processes.
CAT: BRP-01544
CAS: 176755-95-6
Molecular Formula: C48H52F3N6O9P
Molecular Weight: 944.93
Purity: ≥97% by UPLC
Appearance: White or off-white to light yellow powder
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Storage: Store at -20 °C
InChIKey: KXMNUCKTZFTECT-AYACJNLVSA-N
CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=CC(=NC2=O)NC(=O)C=3C=CC=CC3)C1NC(=O)C(F)(F)F)COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C
IUPAC Name: (2R,3S,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2,2,2-trifluoroacetamido)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C48H52F3N6O9P/c1-31(2)57(32(3)4)67(64-29-13-27-52)66-42-39(30-63-47(34-16-11-8-12-17-34,35-18-22-37(61-5)23-19-35)36-20-24-38(62-6)25-21-36)65-44(41(42)55-45(59)48(49,50)51)56-28-26-40(54-46(56)60)53-43(58)33-14-9-7-10-15-33/h7-12,14-26,28,31-32,39,41-42,44H,13,29-30H2,1-6H3,(H,55,59)(H,53,54,58,60)/t39-,41-,42-,44-,67?/m1/s1
Synonyms: 5'-O-DMTr-2'-Trifluoroacetamido-C(Bz)-3'-CE-Phosphoramidite; Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-[(trifluoroacetyl)amino]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; 2'-Amino(TFA) C(Bz) amidite

N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-trifluoroacetamido-2'-deoxyadenosine-3'-cyanoethyl-phosphoramidite

Description: N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-trifluoroacetamido-2'-deoxyadenosine-3'-cyanoethyl-phosphoramidite is a phosphoramidite reagent used in the automated synthesis of modified oligonucleotides. This compound includes a 5'-dimethoxytrityl (DMTr) protecting group for the 5' hydroxyl group, a trifluoroacetamido group at the 2' position to enhance stability and resistance to enzymatic degradation, a benzoyl-protected adenosine base at the N6 position, and a cyanoethyl (CE) phosphoramidite group at the 3' position for efficient nucleotide addition during synthesis. This reagent is employed to create oligonucleotides with enhanced stability and specificity, making it valuable for therapeutic applications such as antisense oligonucleotides and siRNAs, as well as for studying nucleic acid interactions and enzymatic processes.
CAT: BRP-01545
Molecular Formula: C49H52F3N8O8P
Molecular Weight: 968.97
Purity: ≥97% by UPLC
Appearance: White or off-white to light yellow powder
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Storage: Store at -20 °C
InChIKey: MRKCOSUIEKSHSN-MRKXKXNLSA-N
IUPAC Name: (2R,3S,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2,2,2-trifluoroacetamido)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C49H52F3N8O8P/c1-31(2)60(32(3)4)69(66-27-13-26-53)68-42-39(28-65-48(34-16-11-8-12-17-34,35-18-22-37(63-5)23-19-35)36-20-24-38(64-6)25-21-36)67-46(40(42)57-47(62)49(50,51)52)59-30-56-41-43(54-29-55-44(41)59)58-45(61)33-14-9-7-10-15-33/h7-12,14-25,29-32,39-40,42,46H,13,27-28H2,1-6H3,(H,57,62)(H,54,55,58,61)/t39-,40-,42-,46-,69?/m1/s1
Synonyms: 5'-O-DMTr-2'-Trifluoroacetamido-A(Bz)-3'-CE-Phosphoramidite

N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-trifluoroacetamido-2'-deoxyguanosine-3'-cyanoethyl-phosphoramidite

Description: N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-trifluoroacetamido-2'-deoxyguanosine-3'-cyanoethyl-phosphoramidite is a phosphoramidite reagent used in the automated chemical synthesis of modified oligonucleotides. It features a 5'-dimethoxytrityl (DMTr) protecting group for the 5' hydroxyl group, a trifluoroacetamido group at the 2' position for enhanced stability and resistance to enzymatic degradation, an isobutyryl-protected guanosine base at the N2 position, and a cyanoethyl (CE) phosphoramidite group at the 3' position to facilitate the stepwise addition of nucleotides. This reagent is utilized to produce oligonucleotides with improved stability and specificity, making it valuable for therapeutic applications such as antisense oligonucleotides and siRNAs, as well as for advanced research in nucleic acid interactions and enzymatic processes.
CAT: BRP-01546
Molecular Formula: C46H54F3N8O9P
Molecular Weight: 950.95
Purity: ≥97% by UPLC
Appearance: White or off-white to light yellow powder
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Storage: Store at -20 °C
InChIKey: KTSIVWAECVXZMP-OMTUQZFCSA-N
IUPAC Name: (2R,3S,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(2,2,2-trifluoroacetamido)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C46H54F3N8O9P/c1-27(2)40(58)54-44-53-39-37(41(59)55-44)51-26-56(39)42-36(52-43(60)46(47,48)49)38(66-67(64-24-12-23-50)57(28(3)4)29(5)6)35(65-42)25-63-45(30-13-10-9-11-14-30,31-15-19-33(61-7)20-16-31)32-17-21-34(62-8)22-18-32/h9-11,13-22,26-29,35-36,38,42H,12,24-25H2,1-8H3,(H,52,60)(H2,53,54,55,58,59)/t35-,36-,38-,42-,67?/m1/s1
Synonyms: 5'-O-DMTr-2'-Trifluoroacetamido-G(iBu)-3'-CE-Phosphoramidite

N2-Isobutyryl-5'-O-(4-methoxytrityl)-2'-fluoro-2'-deoxyguanosine-3'-cyanoethyl phosphoramidite

Description: N2-Isobutyryl-5'-O-(4-methoxytrityl)-2'-fluoro-2'-deoxyguanosine-3'-cyanoethyl Phosphoramidite plays a crucial role in oligonucleotide synthesis, enhancing stability and specificity through its chemical modifications. The 2'-fluoro substitution increases resistance to enzymatic degradation, while the N2-isobutyryl and 4-methoxytrityl protecting groups ensure precise assembly and protection during synthesis. This compound is instrumental in developing oligonucleotides with tailored properties for applications in therapeutic RNA interference (RNAi), antisense technology, and in-depth studies of nucleic acid interactions and enzymatic processes in molecular biology research.
CAT: BRP-01551
Molecular Formula: C43H51FN7O7P
Molecular Weight: 827.90
Purity: ≥98% by HPLC
Appearance: White or off-white to light yellow powder
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Storage: Store at -20 °C
InChIKey: KHJOOLJXPINFLJ-WCRQIFRASA-N
CanonicalSMILES: N#CCCOP(OC1C(F)C(OC1COC(C=2C=CC=CC2)(C=3C=CC=CC3)C4=CC=C(OC)C=C4)N5C=NC=6C(=O)N=C(NC(=O)C(C)C)NC65)N(C(C)C)C(C)C
IUPAC Name: 2-cyanoethyl ((2R,3R,4R,5R)-4-fluoro-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-(((4-methoxyphenyl)diphenylmethoxy)methyl)tetrahydrofuran-3-yl) diisopropylphosphoramidite
InChI: InChI=1S/C43H51FN7O7P/c1-27(2)39(52)48-42-47-38-36(40(53)49-42)46-26-50(38)41-35(44)37(58-59(56-24-14-23-45)51(28(3)4)29(5)6)34(57-41)25-55-43(30-15-10-8-11-16-30,31-17-12-9-13-18-31)32-19-21-33(54-7)22-20-32/h8-13,15-22,26-29,34-35,37,41H,14,24-25H2,1-7H3,(H2,47,48,49,52,53)/t34-,35-,37-,41-,59?/m1/s1
Synonyms: 5'-O-MMTr-2'-F-dG(iBu) Phosphoramidite

N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxyguanosine-3'-methoxy-phosphoramidite

Description: N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxyguanosine-3'-Methoxy-phosphoramidite is a phosphoramidite reagent used in the synthesis of modified oligonucleotides. It is used in the development of modified oligonucleotides for therapeutic applications like antisense oligonucleotides and siRNAs, as well as in studies involving nucleic acid interactions, gene silencing, and RNA-based therapies.
CAT: BRP-01552
Molecular Formula: C42H52FN6O8P
Molecular Weight: 818.88
Purity: ≥98% by HPLC
Appearance: White or off-white to light yellow powder
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Storage: Store at -20 °C
InChIKey: WEPASXLNAQHNEK-NNYLMNAYSA-N
IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl methyl diisopropylphosphoramidite
InChI: InChI=1S/C42H52FN6O8P/c1-25(2)38(50)46-41-45-37-35(39(51)47-41)44-24-48(37)40-34(43)36(57-58(54-9)49(26(3)4)27(5)6)33(56-40)23-55-42(28-13-11-10-12-14-28,29-15-19-31(52-7)20-16-29)30-17-21-32(53-8)22-18-30/h10-22,24-27,33-34,36,40H,23H2,1-9H3,(H2,45,46,47,50,51)/t33-,34-,36-,40-,58?/m1/s1
Synonyms: 5'-O-DMTr-2'-F-dG(iBu)-3'-Methoxy-phosphoramidite; 2'-F dG(iBu) OMe-amidite; 2'-F Guanosine (n-ibu) Methoxy phosphoramidite

N6-Bz-5'-O-(4,4'-Dimethoxytrityl)-2'-fluoro-2'-deoxyadenosine-3'-methoxy-phosphoramidite

Description: N6-Bz-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxyadenosine-3'-methoxy-phosphoramidite is a specialized phosphoramidite reagent utilized in the synthesis of modified oligonucleotides. This compound features a 5'-dimethoxytrityl (DMTr) protecting group on the 5' hydroxyl group of the sugar, a 2'-fluoro modification on the deoxyribose sugar of adenine, with a benzoyl (Bz) group at the N6 position of the adenine base, and a 3'-methoxy-phosphoramidite functional group necessary for solid-phase oligonucleotide synthesis. It is valuable in developing oligonucleotides for various applications, including gene silencing (e.g., siRNAs) and therapeutic antisense oligonucleotides. Additionally, it facilitates research into nucleic acid structure, function, and interactions.
CAT: BRP-01553
Molecular Formula: C45H50FN6O7P
Molecular Weight: 836.90
Purity: ≥98% by HPLC
Appearance: White or off-white to light yellow powder
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InChIKey: NLZONZKTSFBIDR-AGYRQEKTSA-N
IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl methyl diisopropylphosphoramidite
InChI: InChI=1S/C45H50FN6O7P/c1-29(2)52(30(3)4)60(56-7)59-40-37(58-44(38(40)46)51-28-49-39-41(47-27-48-42(39)51)50-43(53)31-14-10-8-11-15-31)26-57-45(32-16-12-9-13-17-32,33-18-22-35(54-5)23-19-33)34-20-24-36(55-6)25-21-34/h8-25,27-30,37-38,40,44H,26H2,1-7H3,(H,47,48,50,53)/t37-,38-,40-,44-,60?/m1/s1
Synonyms: 5'-O-DMTr-2'-F-dA(Bz)-3'-Methoxy-phosphoramidite; 2'-F dA(Bz) OMe-amidite; 2'-F adenosine (N-Bz) Methoxy phosphoramidite

N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxycytidine-3'-methoxy-phosphoramidite

Description: N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxycytidine-3'-methoxy-phosphoramidite is a specialized phosphoramidite reagent used in the synthesis of modified oligonucleotides. This compound includes a 5'-dimethoxytrityl (DMTr) protecting group on the 5' hydroxyl group of the sugar, a 2'-fluoro modification on the deoxyribose sugar of cytosine, and an acetyl (Ac) group attached to the N4 position of the cytosine base. Additionally, it incorporates a 3'-methoxy-phosphoramidite functional group essential for solid-phase oligonucleotide synthesis. It is valuable in developing oligonucleotides for various applications, including gene expression modulation and antisense therapy. Furthermore, it supports studies exploring nucleic acid structure, function, and interactions.
CAT: BRP-01554
CAS: 1001648-84-5
Molecular Formula: C39H48FN4O8P
Molecular Weight: 750.81
Purity: ≥98% by HPLC
Appearance: White or off-white to light yellow powder
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InChIKey: IGCQRQIRQVZPMT-DJTPZYMWSA-N
CanonicalSMILES: O=C1N=C(C=CN1C2OC(COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)C(OP(OC)N(C(C)C)C(C)C)C2F)NC(=O)C
IUPAC Name: (2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl methyl diisopropylphosphoramidite
InChI: InChI=1S/C39H48FN4O8P/c1-25(2)44(26(3)4)53(49-8)52-36-33(51-37(35(36)40)43-23-22-34(41-27(5)45)42-38(43)46)24-50-39(28-12-10-9-11-13-28,29-14-18-31(47-6)19-15-29)30-16-20-32(48-7)21-17-30/h9-23,25-26,33,35-37H,24H2,1-8H3,(H,41,42,45,46)/t33-,35-,36-,37-,53?/m1/s1
Synonyms: 5'-O-DMTr-2'-F-dC(Ac)-3'-Methoxy-phosphoramidite; 2'-F-Ac-dC-3'-Methoxy-phosphoramidite; 2'-F dC(Ac) OMe-amidite; 2'-F cytidine (N-Ac) Methoxy phosphoramidite; 2'-F C(Ac) OMe-amidite; Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-, 3'-[methyl N,N-bis(1-methylethyl)phosphoramidite]

5'-O-(4,4'-Dimethoxytrityl)-2'-fluoro-2'-deoxyuridine-3'-Methoxy-phosphoramidite

Description: 5'-O-(4,4'-Dimethoxytrityl)-2'-fluoro-2'-deoxyuridine-3'-Methoxy-phosphoramidite is a specialized phosphoramidite reagent utilized in the synthesis of modified oligonucleotides. This compound features a 5'-dimethoxytrityl (DMTr) protecting group on the 5' hydroxyl group of the sugar, a 2'-fluoro modification on the deoxyribose sugar of uracil, and includes a 3'-methoxy-phosphoramidite functional group essential for solid-phase oligonucleotide synthesis. It is valuable in developing oligonucleotides for various applications, including RNA interference (RNAi), antisense therapy, and molecular diagnostics. Additionally, it supports research into nucleic acid structure, function, and interactions.
CAT: BRP-01555
CAS: 136671-61-9
Molecular Formula: C37H45FN3O8P
Molecular Weight: 709.75
Purity: ≥98% by HPLC
Appearance: White or off-white to light yellow powder
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InChIKey: NGPNMGRLSNMJIL-DYVNLQDQSA-N
CanonicalSMILES: O=C1C=CN(C(=O)N1)C2OC(COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)C(OP(OC)N(C(C)C)C(C)C)C2F
IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluorotetrahydrofuran-3-yl methyl diisopropylphosphoramidite
InChI: InChI=1S/C37H45FN3O8P/c1-24(2)41(25(3)4)50(46-7)49-34-31(48-35(33(34)38)40-22-21-32(42)39-36(40)43)23-47-37(26-11-9-8-10-12-26,27-13-17-29(44-5)18-14-27)28-15-19-30(45-6)20-16-28/h8-22,24-25,31,33-35H,23H2,1-7H3,(H,39,42,43)/t31-,33-,34-,35-,50?/m1/s1
Synonyms: 5'-O-DMTr-2'-F-dU-3'-Methoxy-phosphoramidite; 2'-F-dU-3'-Methoxy-phosphoramidite; 2'-F U OMe-amidite; 2'-F uridine methyl phosphoramidite; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-, 3'-[methyl N,N-bis(1-methylethyl)phosphoramidite]; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-, 3'-[methyl bis(1-methylethyl)phosphoramidite]

2'-Fluoro-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyinosine-3'-CE-Phosphoramidite

Description: 2'-Fluoro-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyinosine-3'-CE-Phosphoramidite is a specialized reagent used in oligonucleotide synthesis. It features a 2'-fluoro modification on the deoxyribose sugar of inosine (I), combined with a cyanoethyl (CE) phosphoramidite functional group necessary for solid-phase oligonucleotide synthesis. It is valuable in developing modified oligonucleotides for various applications, including as probes for studying nucleic acid structure, as well as potential therapeutic applications such as antisense therapy and RNA interference (RNAi).
CAT: BRP-01556
CAS: 2245842-16-2
Molecular Formula: C40H46FN6O7P
Molecular Weight: 772.80
Purity: ≥98% by HPLC
Appearance: White powder
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InChIKey: GNQYQPLUWSYXRR-YRGZVQMCSA-N
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1F)N2C=NC3=C2N=CNC3=O)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC
IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-fluoro-5-(6-oxo-1H-purin-9-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
InChI: InChI=1S/C40H46FN6O7P/c1-26(2)47(27(3)4)55(52-22-10-21-42)54-36-33(53-39(34(36)41)46-25-45-35-37(46)43-24-44-38(35)48)23-51-40(28-11-8-7-9-12-28,29-13-17-31(49-5)18-14-29)30-15-19-32(50-6)20-16-30/h7-9,11-20,24-27,33-34,36,39H,10,22-23H2,1-6H3,(H,43,44,48)/t33-,34-,36-,39-,55?/m1/s1
Synonyms: 2'-F-dI-CE-Phosphoramidite; 2'-F I amidite; 2'-Fluoro-5'-O-DMT-2'-deoxyinosine-3'-CE-phosphoramidite; 5'-O-(4,4'-Dimethoxytrityl)-2'-fluoro-2'-deoxyinosine-3'-cyanoethyl phosphoramidite; 2'-F dI amidite

2'-F MeC(pac) amidite

Description: 2'-F MeC(pac) amidite is a phosphoramidite used in the chemical synthesis of RNA oligonucleotides. The 2'-fluorine modification enhances the stability of the RNA by increasing resistance to enzymatic degradation. The methylcytosine base modification can impact gene expression and epigenetic regulation. The phenoxyacetyl (pac) group serves as a protective group, ensuring the fidelity of synthesis. This amidite allows for the production of modified RNA sequences with improved stability and functional properties.
CAT: BRP-01557
Molecular Formula: C48H55FN5O9P
Molecular Weight: 895.97
Purity: >95%
Appearance: Off-white solid
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InChIKey: PBAZJAWJLKEWTI-UVFJTNPGSA-N
Solubility: Soluble in Acetonitrile, DMF
IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(5-methyl-2-oxo-4-(2-phenoxyacetamido)pyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C48H55FN5O9P/c1-32(2)54(33(3)4)64(61-28-14-27-50)63-44-41(62-46(43(44)49)53-29-34(5)45(52-47(53)56)51-42(55)31-59-40-17-12-9-13-18-40)30-60-48(35-15-10-8-11-16-35,36-19-23-38(57-6)24-20-36)37-21-25-39(58-7)26-22-37/h8-13,15-26,29,32-33,41,43-44,46H,14,28,30-31H2,1-7H3,(H,51,52,55,56)/t41-,43-,44-,46-,64?/m1/s1
Synonyms: 5'-O-DMT-2'-F-MeC(pac) 3'-CE Phosphoramidite; 2'-F-MeC(pac) CE-Phosphoramidite; 2'-F-5-Me-dC(pac) CE-Phosphoramidite

2'-F MeC(dmf) amidite

Description: 2'-F MeC(dmf) amidite is a phosphoramidite used in the chemical synthesis of RNA oligonucleotides. This compound features a 2'-fluorine modification, which enhances the stability of the RNA by increasing its resistance to enzymatic degradation. The cytosine base in this amidite is methylated (MeC), which can play a role in gene expression and epigenetic regulation. The dimethylformamide (dmf) group acts as a protective group, ensuring the proper synthesis of the RNA strand by preventing unwanted side reactions. This amidite is crucial for producing modified RNA sequences with enhanced stability and functionality.
CAT: BRP-01558
Molecular Formula: C43H54FN6O7P
Molecular Weight: 816.91
Purity: >98%
Appearance: Off-white solid
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InChIKey: ADENSOMHVRAGEH-KZQAAKLLSA-N
Solubility: Soluble in Acetonitrile, DMF
IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(4-(((dimethylamino)methylene)amino)-5-methyl-2-oxopyrimidin-1(2H)-yl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C43H54FN6O7P/c1-29(2)50(30(3)4)58(55-25-13-24-45)57-39-37(56-41(38(39)44)49-26-31(5)40(47-42(49)51)46-28-48(6)7)27-54-43(32-14-11-10-12-15-32,33-16-20-35(52-8)21-17-33)34-18-22-36(53-9)23-19-34/h10-12,14-23,26,28-30,37-39,41H,13,25,27H2,1-9H3/t37-,38-,39-,41-,58?/m1/s1
Synonyms: 5'-O-DMT-2'-F-MeC(dmf) 3'-CE Phosphoramidite; 2'-F-MeC(dmf) CE-Phosphoramidite; 2'-F-5-Me-dC(dmf) CE-Phosphoramidite

2'-F A(dmf) amidite

Description: 2'-F A(dmf) amidite is a phosphoramidite used in the chemical synthesis of RNA oligonucleotides. This compound includes a 2'-fluorine modification, which enhances RNA stability by increasing resistance to enzymatic degradation. The adenine base in this amidite has a dimethylformamide (dmf) protective group, which helps prevent unwanted side reactions during the synthesis process. This modification is crucial for producing RNA sequences with improved stability and integrity, facilitating their use in various research and therapeutic applications.
CAT: BRP-01559
Molecular Formula: C43H52FN8O6P
Molecular Weight: 826.91
Purity: >98%
Appearance: Off-white solid
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InChIKey: NOGLCHLULIFCJH-ZXYFHBOTSA-N
Solubility: Soluble in Acetonitrile, DMF
IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(6-(((dimethylamino)methylene)amino)-9H-purin-9-yl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C43H52FN8O6P/c1-29(2)52(30(3)4)59(56-24-12-23-45)58-39-36(57-42(37(39)44)51-28-48-38-40(49-27-50(5)6)46-26-47-41(38)51)25-55-43(31-13-10-9-11-14-31,32-15-19-34(53-7)20-16-32)33-17-21-35(54-8)22-18-33/h9-11,13-22,26-30,36-37,39,42H,12,24-25H2,1-8H3/t36-,37-,39-,42-,59?/m1/s1
Synonyms: 2'-Fluoro-2'-deoxy Adenosine (N,N-DMF) CED Phosphoramidite; 5'-O-DMT-2'-F-A(dmf) 3'-CE Phosphoramidite; 2'-F-A(dmf) CE-Phosphoramidite; 2'-F-dA(dmf) 3'-CE-Phosphoramidite

2'-F A(pac) amidite

Description: 2'-F A(pac) amidite is a phosphoramidite used in the chemical synthesis of RNA oligonucleotides. The 2'-fluorine modification enhances the stability of the RNA by making it more resistant to enzymatic degradation. The adenine base in this amidite has a phenoxyacetyl (pac) protective group, which prevents unwanted side reactions during the synthesis process. This amidite is essential for producing RNA sequences with enhanced stability and integrity, making them suitable for various research and therapeutic applications.
CAT: BRP-01560
Molecular Formula: C48H53FN7O8P
Molecular Weight: 905.96
Purity: >95%
Appearance: Off-white solid
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Storage: Store at -20 °C
InChIKey: IPGFEHRBBLWVPH-NNMVWRAKSA-N
Solubility: Soluble in Acetonitrile, DMF
IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(6-(2-phenoxyacetamido)-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C48H53FN7O8P/c1-32(2)56(33(3)4)65(62-27-13-26-50)64-44-40(28-61-48(34-14-9-7-10-15-34,35-18-22-37(58-5)23-19-35)36-20-24-38(59-6)25-21-36)63-47(42(44)49)55-31-53-43-45(51-30-52-46(43)55)54-41(57)29-60-39-16-11-8-12-17-39/h7-12,14-25,30-33,40,42,44,47H,13,27-29H2,1-6H3,(H,51,52,54,57)/t40-,42-,44-,47-,65?/m1/s1
Synonyms: 2'-Fluoro-2'-deoxy Adenosine (Pac) CED Phosphoramidite; 5'-O-DMT-2'-F-A(Pac) 3'-CE Phosphoramidite; 2'-F-A(Pac) CE-Phosphoramidite; 2'-F-dA(Pac) 3'-CE-Phosphoramidite

2'-F C(pac) amidite

Description: 2'-F C(pac) amidite is a phosphoramidite used in the chemical synthesis of RNA oligonucleotides. The 2'-fluorine modification enhances the stability of the RNA by making it more resistant to enzymatic degradation. The cytosine base in this compound has a phenoxyacetyl (pac) group, which serves as a protective group during the synthesis process, preventing undesired reactions. This amidite allows for the production of RNA sequences with improved stability and integrity, facilitating various applications in research and therapeutics.
CAT: BRP-01561
Molecular Formula: C47H53FN5O9P
Molecular Weight: 881.94
Purity: >98%
Appearance: Off-white solid
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InChIKey: ARQJQDCNAYPRPA-DRPJRLOZSA-N
Solubility: Soluble in Acetonitrile, DMF
IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(2-oxo-4-(2-phenoxyacetamido)pyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C47H53FN5O9P/c1-32(2)53(33(3)4)63(60-29-13-27-49)62-44-40(61-45(43(44)48)52-28-26-41(51-46(52)55)50-42(54)31-58-39-16-11-8-12-17-39)30-59-47(34-14-9-7-10-15-34,35-18-22-37(56-5)23-19-35)36-20-24-38(57-6)25-21-36/h7-12,14-26,28,32-33,40,43-45H,13,29-31H2,1-6H3,(H,50,51,54,55)/t40-,43-,44-,45-,63?/m1/s1
Synonyms: 5'-O-DMT-2'-F-C(pac) 3'-CE Phosphoramidite; 2'-F-C(pac) CE-Phosphoramidite; 2'-F-dC(pac) CE-Phosphoramidite

2'-F G(iPr-pac) amidite

Description: 2'-F G(iPr-pac) amidite is a phosphoramidite used in the chemical synthesis of RNA oligonucleotides. This compound features a 2'-fluorine modification, which enhances RNA stability by increasing resistance to enzymatic degradation. The guanine base in this amidite is protected with an isopropyl phenoxyacetyl (iPr-pac) group, which prevents unwanted side reactions during the synthesis process. This amidite is crucial for producing RNA sequences with improved stability and integrity, facilitating their use in various research and therapeutic applications.
CAT: BRP-01562
Molecular Formula: C51H59FN7O9P
Molecular Weight: 964.04
Purity: >98%
Appearance: Off-white solid
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InChIKey: XMOAKDDRWSAKSB-PHZZPARGSA-N
Solubility: Soluble in Acetonitrile, DMF
IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(2-(2-(4-isopropylphenoxy)acetamido)-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C51H59FN7O9P/c1-32(2)35-15-21-41(22-16-35)64-30-43(60)55-50-56-47-45(48(61)57-50)54-31-58(47)49-44(52)46(68-69(66-28-12-27-53)59(33(3)4)34(5)6)42(67-49)29-65-51(36-13-10-9-11-14-36,37-17-23-39(62-7)24-18-37)38-19-25-40(63-8)26-20-38/h9-11,13-26,31-34,42,44,46,49H,12,28-30H2,1-8H3,(H2,55,56,57,60,61)/t42-,44-,46-,49-,69?/m1/s1
Synonyms: 5'-O-DMT-2'-F-G(iPr-pac) 3'-CE Phosphoramidite; 2'-F-G(iPr-pac) CE-Phosphoramidite; 2'-F-dG(iPr-pac) 3'-CE-Phosphoramidite
* Only for research. Not suitable for any diagnostic or therapeutic use.
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