Phosphoramidites

ICG-NHS

Description: ICG-NHS is synthesized by conjugating NHS to the carboxyl group of ICG, creating an activated ester. This NHS-activated ICG can then react specifically with primary amines on molecules like proteins, peptides, or oligonucleotides to form stable amide bonds. ICG-NHS conjugates are commonly used for labeling biomolecules for imaging, targeting, or drug delivery purposes in biological research and medical diagnostics.

CAT: BRP-01518

CAS: 1622335-40-3

Molecular Formula: C49H53N3O7S

Molecular Weight: 828.03

Purity: ≥95%

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InChIKey: KDJUNNVUQBKNAY-UHFFFAOYSA-N

CanonicalSMILES: CC1(C(=[N+](C2=C1C3=CC=CC=C3C=C2)CCCCCC(=O)ON4C(=O)CCC4=O)C=CC=CC=CC=C5C(C6=C(N5CCCCS(=O)(=O)[O-])C=CC7=CC=CC=C76)(C)C)C

IUPAC Name: 4-[2-[7-[3-[6-(2,5-dioxopyrrolidin-1-yl)oxy-6-oxohexyl]-1,1-dimethylbenzo[e]indol-3-ium-2-yl]hepta-2,4,6-trienylidene]-1,1-dimethylbenzo[e]indol-3-yl]butane-1-sulfonate

InChI: InChI=1S/C49H53N3O7S/c1-48(2)41(50(39-28-26-35-19-12-14-21-37(35)46(39)48)32-16-8-11-25-45(55)59-52-43(53)30-31-44(52)54)23-9-6-5-7-10-24-42-49(3,4)47-38-22-15-13-20-36(38)27-29-40(47)51(42)33-17-18-34-60(56,57)58/h5-7,9-10,12-15,19-24,26-29H,8,11,16-18,25,30-34H2,1-4H3

Synonyms: 1H-Benz[e]indolium, 2-[7-[1,3-dihydro-1,1-dimethyl-3-(4-sulfobutyl)-2H-benz[e]indol-2-ylidene]-1,3,5-heptatrien-1-yl]-3-[6-[(2,5-dioxo-1-pyrrolidinyl)oxy]-6-oxohexyl]-1,1-dimethyl-, inner salt; Indocyanine Green-NHS; 4-(2-(7-(3-(6-((2,5-dioxopyrrolidin-1-yl)oxy)-6-oxohexyl)-1,1-dimethyl-1H-benzo[e]indol-3-ium-2-yl)hepta-2,4,6-trien-1-ylidene)-1,1-dimethyl-1,2-dihydro-3H-benzo[e]indol-3-yl)butane-1-sulfonate; ICG-OSu; ICG NHS ester; ICG-NHS(mono-sulfo-cy7.5 NHS)

12-((2S,4R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxypyrrolidin-1-yl)-12-oxododecanoic acid

Description: 12-((2S,4R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxypyrrolidin-1-yl)-12-oxododecanoic acid is a chemically modified carbohydrate derivative. The peracetylation enhances its stability and lipophilicity, while the GalNAc moiety facilitates specific biological interactions, often used in targeted drug delivery systems. The L96-Acid acts as a linker to connect GalNAc to other functional groups or molecules, and the TEA salt ensures solubility and stability in solution. This compound is useful in pharmaceutical and biochemical applications, particularly in the development of targeted therapeutics and diagnostic agents.

CAT: BRP-01519

CAS: 1159408-70-4

Molecular Formula: C38H49NO7

Molecular Weight: 631.81

Purity: ≥95%

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Density: 1.154±0.06 g/cm3

Boiling Point: 779.4±60.0 °C at 760 mmHg

InChIKey: CEYLTMDXADTBEL-JHOUSYSJSA-N

CanonicalSMILES: COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)OCC4CC(CN4C(=O)CCCCCCCCCCC(=O)O)O

IUPAC Name: 12-[(2S,4R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxypyrrolidin-1-yl]-12-oxododecanoic acid

InChI: InChI=1S/C38H49NO7/c1-44-34-22-18-30(19-23-34)38(29-14-10-9-11-15-29,31-20-24-35(45-2)25-21-31)46-28-32-26-33(40)27-39(32)36(41)16-12-7-5-3-4-6-8-13-17-37(42)43/h9-11,14-15,18-25,32-33,40H,3-8,12-13,16-17,26-28H2,1-2H3,(H,42,43)/t32-,33+/m0/s1

Synonyms: 1-Pyrrolidinedodecanoic acid, 2-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-4-hydroxy-λ-oxo-, (2S,4R)-; (2S,4R)-2-[[Bis(4-methoxyphenyl)phenylmethoxy]methyl]-4-hydroxy-λ-oxo-1-pyrrolidinedodecanoic acid; Peracetylated GalNAc-L96-Acid-2

5'-DMT-PseudoUridine-CE-Phosphoramidite

Description: 5'-DMT-PseudoUridine-CE-Phosphoramidite is a phosphoramidite used in the chemical synthesis of oligonucleotides. This compound features a 5'-dimethoxytrityl (DMT) protecting group and a cyanoethyl (CE) phosphoramidite moiety, making it compatible with automated DNA/RNA synthesis protocols. Incorporating pseudouridine into synthetic RNA strands using this phosphoramidite is particularly valuable for research into RNA modifications, as pseudouridine can influence RNA stability, folding, and function. This tool aids in the development of RNA-based therapeutics and the study of RNA biology, enabling detailed exploration of pseudouridine's role in various cellular processes.

CAT: BRP-01520

CAS: 1244969-51-4

Molecular Formula: C39H47N4O9P

Molecular Weight: 746.79

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InChIKey: OMNBXPQZUMXZPM-LWYRIDHVSA-N

CanonicalSMILES: N#CCCOP(OC1C(O)C(OC1COC(C=2C=CC=CC2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)C5=CNC(=O)NC5=O)N(C(C)C)C(C)C

IUPAC Name: (2R,3S,4S,5S)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-4-hydroxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C39H47N4O9P/c1-25(2)43(26(3)4)53(50-22-10-21-40)52-36-33(51-35(34(36)44)32-23-41-38(46)42-37(32)45)24-49-39(27-11-8-7-9-12-27,28-13-17-30(47-5)18-14-28)29-15-19-31(48-6)20-16-29/h7-9,11-20,23,25-26,33-36,44H,10,22,24H2,1-6H3,(H2,41,42,45,46)/t33-,34+,35+,36-,53?/m1/s1

Synonyms: 2,4(1H,3H)-Pyrimidinedione, 5-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-β-D-ribofuranosyl]-; 5-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-β-D-ribofuranosyl]-2,4(1H,3H)-pyrimidinedione; 5'-DMT-PseudoUridine 3'-CE-Phosphoramidite

5'-ODMT cEt G Phosphoramidite (Amidite)

Description: 5'-ODMT cEt G Phosphoramidite is a specialized chemical reagent used in the synthesis of oligonucleotides. This compound features a guanosine (G) base modified with a 5'-O-(4,4'-dimethoxytrityl) (DMT) protecting group and a constrained ethyl (cEt) modification. The constrained ethyl (cEt) modification is designed to enhance the stability and binding affinity of the oligonucleotide, making it more resistant to nuclease degradation and improving its hybridization properties. This modification is particularly useful in the development of therapeutic oligonucleotides, such as antisense oligonucleotides, small interfering RNAs (siRNAs), and other nucleic acid-based drugs.

CAT: BRP-01526

CAS: 945628-66-0

Molecular Formula: C46H56N7O9P

Molecular Weight: 881.95

Purity: ≥98% by HPLC

Appearance: White to off-white solid

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Storage: Store at -20 °C, stored under nitrogen, away from moisture

InChIKey: VMDSRWMHPUGGSZ-KHGLYSIJSA-N

Solubility: Soluble in DMSO

CanonicalSMILES: CC1C2(C(C(O1)C(O2)N3C=NC4=C3N=C(NC4=O)NC(=O)C(C)C)OP(N(C(C)C)C(C)C)OCCC#N)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC

IUPAC Name: N-[9-[(1S,3R,4R,6S,7S)-1-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-7-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-6-methyl-2,5-dioxabicyclo[2.2.1]heptan-3-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide

InChI: InChI=1S/C46H56N7O9P/c1-28(2)41(54)50-44-49-40-37(42(55)51-44)48-27-52(40)43-38-39(62-63(59-25-13-24-47)53(29(3)4)30(5)6)45(61-43,31(7)60-38)26-58-46(32-14-11-10-12-15-32,33-16-20-35(56-8)21-17-33)34-18-22-36(57-9)23-19-34/h10-12,14-23,27-31,38-39,43H,13,25-26H2,1-9H3,(H2,49,50,51,54,55)/t31-,38+,39-,43+,45-,63?/m0/s1

Synonyms: N2-ibu-G-(S)-cEt-Phosphoramidite; 5'-ODMT cEt G Phosphoramidite; S-cEt-G phosphoramidite; (1S,3R,4R,6S,7S)-1-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-6-methyl-2,5-dioxabicyclo[2.2.1]heptan-7-yl (2-cyanoethyl) diisopropylphosphoramidite; N-[9-[2,5-Anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-6-deoxy-α-L-mannofuranosyl]-6,9-dihydro-6-oxo-1H-purin-2-yl]-2-methylpropanamide; S-cEt-G(iBu) phosphoramidite; CET-rG(ibu) Phosphoramidite; S-cEt-G(iBu)-CE-Phosphoramidite

5'-ODMT cEt m5U Phosphoramidite (Amidite)

Description: 5'-ODMT cEt m5U Phosphoramidite (Amidite) is a specialized chemical reagent used in the synthesis of oligonucleotides. This compound features a modified uridine (m5U) base, where the uridine is methylated at the 5-position, and includes a constrained ethyl (cEt) modification. Additionally, the 5' hydroxyl group is protected by a 4,4'-dimethoxytrityl (DMT) group. The constrained ethyl (cEt) modification enhances the stability and binding affinity of the oligonucleotide, making it more resistant to nuclease degradation and improving its hybridization properties. The methylation at the 5-position of uridine (m5U) is known to influence the binding affinity and specificity of the oligonucleotide to its target. This phosphoramidite is particularly useful in the development of therapeutic oligonucleotides, such as antisense oligonucleotides, small interfering RNAs (siRNAs), and other nucleic acid-based drugs, where enhanced stability and binding affinity are crucial for efficacy.

CAT: BRP-01527

CAS: 1197033-22-9

Molecular Formula: C42H51N4O9P

Molecular Weight: 786.86

Purity: ≥98% by HPLC

Appearance: White to off-white solid

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Storage: Store at -20 °C, stored under nitrogen, away from moisture

InChIKey: SEFBXGXPINACNI-IMMRMUFKSA-N

Solubility: Soluble in DMSO

CanonicalSMILES: CC1C2(C(C(O1)C(O2)N3C=C(C(=O)NC3=O)C)OP(N(C(C)C)C(C)C)OCCC#N)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: 3-[[(1S,3R,4R,6S,7S)-1-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-6-methyl-3-(5-methyl-2,4-dioxopyrimidin-1-yl)-2,5-dioxabicyclo[2.2.1]heptan-7-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C42H51N4O9P/c1-27(2)46(28(3)4)56(52-24-12-23-43)55-37-36-39(45-25-29(5)38(47)44-40(45)48)54-41(37,30(6)53-36)26-51-42(31-13-10-9-11-14-31,32-15-19-34(49-7)20-16-32)33-17-21-35(50-8)22-18-33/h9-11,13-22,25,27-28,30,36-37,39H,12,24,26H2,1-8H3,(H,44,47,48)/t30-,36+,37-,39+,41-,56?/m0/s1

Synonyms: 1-[2,5-Anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-6-deoxy-α-L-mannofuranosyl]-5-methyl-2,4(1H,3H)-pyrimidinedione; 5'-ODMT cEt m5U Phosphoramidite; S-cEt-m5U phosphoramidite; CET-m5U Phosphoramidite; S-cEt-m5U-CE-Phosphoramidite; S-cEt-T phosphoramidite; CET-5-Me-U Phosphoramidite; S-cEt-T-CE-Phosphoramidite

5'-ODMT cEt N-Bz A Phosphoramidite (Amidite)

Description: 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) is a specialized reagent used in the chemical synthesis of oligonucleotides. This compound features an adenine (A) base with an N6-benzoyl (N-Bz) protection and a constrained ethyl (cEt) modification, along with a 5'-O-(4,4'-dimethoxytrityl) (DMT) protecting group. The constrained ethyl (cEt) modification enhances the stability and binding affinity of the oligonucleotide. This modification increases resistance to nuclease degradation and improves hybridization properties, making the resulting oligonucleotide more effective for various applications, including therapeutic uses. 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) is an important reagent for the synthesis of modified oligonucleotides, offering enhanced stability, binding affinity, and efficacy. It is particularly useful in the development of therapeutic oligonucleotides and other advanced nucleic acid-based research applications.

CAT: BRP-01528

CAS: 1197033-19-4

Molecular Formula: C49H54N7O8P

Molecular Weight: 899.97

Purity: ≥98% by HPLC

Appearance: White to off-white solid

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Storage: Store at -20 °C, stored under nitrogen, away from moisture

InChIKey: XHEVZGBLRSIPCO-DZGFXGBPSA-N

Solubility: Soluble in DMSO

CanonicalSMILES: CC1C2(C(C(O1)C(O2)N3C=NC4=C(N=CN=C43)NC(=O)C5=CC=CC=C5)OP(N(C(C)C)C(C)C)OCCC#N)COC(C6=CC=CC=C6)(C7=CC=C(C=C7)OC)C8=CC=C(C=C8)OC

InChI: InChI=1S/C49H54N7O8P/c1-32(2)56(33(3)4)65(61-28-14-27-50)64-43-42-47(55-31-53-41-44(51-30-52-45(41)55)54-46(57)35-15-10-8-11-16-35)63-48(43,34(5)62-42)29-60-49(36-17-12-9-13-18-36,37-19-23-39(58-6)24-20-37)38-21-25-40(59-7)26-22-38/h8-13,15-26,30-34,42-43,47H,14,28-29H2,1-7H3,(H,51,52,54,57)/t34-,42+,43-,47+,48-,65?/m0/s1

Synonyms: S-cEt-A phosphoramidite; 5'-ODMT cEt N-Bz A Phosphoramidite; 5'-ODMT cEt A(Bz) Phosphoramidite; N6-Bz-2'-O-4'-A-Locked-Ar-CET-Phosphoramidite; CET-A(Bz) Phosphoramidite; 5'-ODMT cEt N-Bz A Phosphoramidite Amidite; S-cEt-A(Bz)-CE-Phosphoramidite; N-[9-[2,5-Anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-6-deoxy-α-L-mannofuranosyl]-9H-purin-6-yl]benzamide

5'-ODMT cEt U Phosphoramidite (Amidite)

Description: 5'-ODMT cEt U Phosphoramidite (Amidite) is a specialized chemical reagent used in the synthesis of oligonucleotides. This compound features a uridine (U) base modified with a 5'-O-(4,4'-dimethoxytrityl) (DMT) protecting group and a constrained ethyl (cEt) modification. The constrained ethyl (cEt) modification is designed to enhance the stability and binding affinity of the oligonucleotide. This modification makes the oligonucleotide more resistant to nuclease degradation and improves its hybridization properties. The use of such modifications is particularly important in the development of therapeutic oligonucleotides, such as antisense oligonucleotides, small interfering RNAs (siRNAs), and other nucleic acid-based drugs, where stability and binding affinity are crucial for efficacy.

CAT: BRP-01529

CAS: 945628-51-3

Molecular Formula: C41H49N4O9P

Molecular Weight: 772.82

Purity: ≥98% by HPLC

Appearance: White to off-white solid

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Storage: Store at -20 °C, stored under nitrogen, away from moisture

InChIKey: MCMVDDGYNXOEJR-ZDHUYCFVSA-N

Solubility: Soluble in DMSO

CanonicalSMILES: CC1C2(C(C(O1)C(O2)N3C=CC(=O)NC3=O)OP(N(C(C)C)C(C)C)OCCC#N)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: 3-[[(1S,3R,4R,6S,7S)-1-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-(2,4-dioxopyrimidin-1-yl)-6-methyl-2,5-dioxabicyclo[2.2.1]heptan-7-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C41H49N4O9P/c1-27(2)45(28(3)4)55(51-25-11-23-42)54-37-36-38(44-24-22-35(46)43-39(44)47)53-40(37,29(5)52-36)26-50-41(30-12-9-8-10-13-30,31-14-18-33(48-6)19-15-31)32-16-20-34(49-7)21-17-32/h8-10,12-22,24,27-29,36-38H,11,25-26H2,1-7H3,(H,43,46,47)/t29-,36+,37-,38+,40-,55?/m0/s1

Synonyms: U-(S)-cEt-Phosphoramidite; 1-[2,5-Anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-6-deoxy-α-L-mannofuranosyl]-2,4(1H,3H)-pyrimidinedione; 5'-ODMT cEt U Phosphoramidite; S-cEt-U phosphoramidite; CET-U Phosphoramidite; S-cEt-U-CE-Phosphoramidite; cEt U Amidite

5'-ODMT cEt N-Bz C Phosphoramidite (Amidite)

Description: 5'-ODMT cEt N-Bz C Phosphoramidite (Amidite) is a specialized chemical reagent used in the synthesis of modified oligonucleotides. This compound features a cytosine (C) base with an N4-benzoyl (N-Bz) protecting group and a constrained ethyl (cEt) modification, along with a 5'-O-(4,4'-dimethoxytrityl) (DMT) protective group. The constrained ethyl (cEt) modification enhances the stability and binding affinity of the resulting oligonucleotide. This modification increases resistance to nuclease degradation and improves hybridization properties, which is crucial for various research and therapeutic applications. 5'-ODMT cEt N-Bz C Phosphoramidite (Amidite) is an essential reagent for synthesizing modified oligonucleotides, providing enhanced stability, binding affinity, and resistance to degradation, particularly useful in developing advanced nucleic acid-based therapeutics and research tools.

CAT: BRP-01530

CAS: 945628-57-9

Molecular Formula: C48H54N5O9P

Molecular Weight: 875.94

Purity: ≥98% by HPLC

Appearance: White to off-white solid

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Storage: Store at -20 °C, stored under nitrogen, away from moisture

InChIKey: QLEUKMYYYZVVED-INXIQYKVSA-N

Solubility: Soluble in DMSO

CanonicalSMILES: CC1C2(C(C(O1)C(O2)N3C=CC(=NC3=O)NC(=O)C4=CC=CC=C4)OP(N(C(C)C)C(C)C)OCCC#N)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC

IUPAC Name: N-[1-[(1S,3R,4R,6S,7S)-1-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-7-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-6-methyl-2,5-dioxabicyclo[2.2.1]heptan-3-yl]-2-oxopyrimidin-4-yl]benzamide

InChI: InChI=1S/C48H54N5O9P/c1-32(2)53(33(3)4)63(59-30-14-28-49)62-43-42-45(52-29-27-41(51-46(52)55)50-44(54)35-15-10-8-11-16-35)61-47(43,34(5)60-42)31-58-48(36-17-12-9-13-18-36,37-19-23-39(56-6)24-20-37)38-21-25-40(57-7)26-22-38/h8-13,15-27,29,32-34,42-43,45H,14,30-31H2,1-7H3,(H,50,51,54,55)/t34-,42+,43-,45+,47-,63?/m0/s1

Synonyms: S-cEt-C phosphoramidite; 5'-ODMT cEt N-Bz C Phosphoramidite; 5'-ODMT cEt C(Bz) Phosphoramidite; N4-Bz-2'-O-4'-A-Locked-Cr-CET-Phosphoramidite; CET-C(Bz) Phosphoramidite; 5'-ODMT cEt N-Bz C Phosphoramidite Amidite; S-cEt-C(Bz)-CE-Phosphoramidite; N-[1-[2,5-Anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-6-deoxy-α-L-mannofuranosyl]-1,2-dihydro-2-oxo-4-pyrimidinyl]benzamide

DMT-2'-F-dG(DMF)-CE-Phosphoramidite

Description: DMT-2'-F-dG(DMF)-CE-Phosphoramidite is a chemically modified phosphoramidite utilized in the solid-phase synthesis of oligonucleotides. The modifications, including the fluorine at the 2' position and the protecting groups, enhance the stability and specificity of the synthesized oligonucleotides. These modifications can be critical for applications in genetic research, diagnostics, and the development of antisense oligonucleotides, siRNA, and other nucleic acid-based therapeutics. The fluorine substitution particularly contributes to increased resistance against enzymatic degradation, making the oligonucleotides more durable and effective in biological systems.

CAT: BRP-01539

Molecular Formula: C43H52FN8O7P

Molecular Weight: 842.91

Purity: ≥98%

Appearance: White solid

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Storage: Store at -20 °C

InChIKey: BUKKJOTXODUNQK-PKTARBJSSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1F)N2C=NC3=C2N=C(NC3=O)N=CN(C)C)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: N'-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-fluorooxolan-2-yl]-6-oxo-1H-purin-2-yl]-N,N-dimethylmethanimidamide

InChI: InChI=1S/C43H52FN8O7P/c1-28(2)52(29(3)4)60(57-24-12-23-45)59-38-35(58-41(36(38)44)51-27-46-37-39(51)48-42(49-40(37)53)47-26-50(5)6)25-56-43(30-13-10-9-11-14-30,31-15-19-33(54-7)20-16-31)32-17-21-34(55-8)22-18-32/h9-11,13-22,26-29,35-36,38,41H,12,24-25H2,1-8H3,(H,48,49,53)/t35-,36-,38-,41-,60?/m1/s1

Synonyms: 2'-F G(dmf) amidite; 2'-Fluoro-2'-deoxy Guanosine (N,N-DMF) CED Phosphoramidite; (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-(((dimethylamino)methylene)amino)-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

Related CAS: 1391913-24-8 (N'-[9-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-deoxy-2-fluoro-β-D-arabinofuranosyl]-6,9-dihydro-6-oxo-1H-purin-2-yl]-N,N-dimethylmethanimidamide)

5-Me-5'-O-DMT-N4-Acetyl-2'-fluoro-2'-deoxy-cytidine 3'-CE phosphoramidite

Description: 5-Me-5'-O-DMT-N4-Acetyl-2'-fluoro-2'-deoxy-cytidine 3'-CE phosphoramidite is used in the synthesis of modified oligonucleotides to enhance their stability, specificity, and resistance to enzymatic degradation, making it valuable for developing therapeutic agents such as antisense oligonucleotides and siRNAs, as well as for studying nucleic acid interactions and enzymatic processes in research.

CAT: BRP-01540

Molecular Formula: C42H51FN5O8P

Molecular Weight: 803.87

Purity: >98%

Appearance: White to off-white powder

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InChIKey: XKIOEQRURPSLHT-FNZMFDOGSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4R,5R)-5-(4-acetamido-5-methyl-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C42H51FN5O8P/c1-27(2)48(28(3)4)57(54-24-12-23-44)56-38-36(55-40(37(38)43)47-25-29(5)39(45-30(6)49)46-41(47)50)26-53-42(31-13-10-9-11-14-31,32-15-19-34(51-7)20-16-32)33-17-21-35(52-8)22-18-33/h9-11,13-22,25,27-28,36-38,40H,12,24,26H2,1-8H3,(H,45,46,49,50)/t36-,37-,38-,40-,57?/m1/s1

Synonyms: 2'-F MeC(Ac) amidite; N4-Acetyl-2'-deoxy-5'-O-DMT-2'-fluoro-5-methylcytidine 3'-CE phosphoramidite; 2'-Fluoro-5MeC(Ac)-3'-phosphoramidite; 5-Me-N4-Ac-5'-O-DMT-2'-fluoro-2'-deoxy-cytidine 3'-CE phosphoramidite; N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-fluoro-5-methylcytidine-3'-O-[(2-cyanoethyl)(N,N-diisopropyl)]phosphoramidite; N4-Ac-5'-O-DMTr-2'-deoxy-2'-fluoro-5-methylcytidine-3'-CED phosphoramidite; N-Acetyl-2'-deoxy-5'-O-DMT-2'-fluoro-5-methylcytidine 3'-CE phosphoramidite; DMT-2'-F-dC(Ac)-CE-Phosphoramidite

5'-O-(4,4'-Dimethoxytrityl)-2'-trifluoroacetamido-2'-deoxyuridine-3'-cyanoethyl-phosphoramidite

Description: 5'-O-(4,4'-Dimethoxytrityl)-2'-trifluoroacetamido-2'-deoxyuridine-3'-cyanoethyl-phosphoramidite is a phosphoramidite reagent used in the automated synthesis of modified oligonucleotides. This reagent includes a 5'-dimethoxytrityl (DMTr) protecting group for the 5' hydroxyl group, a trifluoroacetamido group at the 2' position for increased stability and resistance to enzymatic degradation, uridine as the nucleobase, and a cyanoethyl (CE) phosphoramidite group at the 3' position for efficient nucleotide addition during synthesis. It is employed to create oligonucleotides with enhanced stability and specificity, making it valuable for therapeutic applications like antisense oligonucleotides and siRNAs, as well as for researching nucleic acid interactions and enzymatic processes.

CAT: BRP-01542

CAS: 126139-44-4

Molecular Formula: C41H47F3N5O9P

Molecular Weight: 841.82

Purity: ≥97% by UPLC

Appearance: White or off-white to light yellow powder

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Melting Point: 240-243 °C

InChIKey: SSRAEXJTISFPEB-WEYVJJSGSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1NC(=O)C(F)(F)F)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: N-[(2R,3R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-2-(2,4-dioxopyrimidin-1-yl)oxolan-3-yl]-2,2,2-trifluoroacetamide

InChI: InChI=1S/C41H47F3N5O9P/c1-26(2)49(27(3)4)59(56-24-10-22-45)58-36-33(57-37(35(36)47-38(51)41(42,43)44)48-23-21-34(50)46-39(48)52)25-55-40(28-11-8-7-9-12-28,29-13-17-31(53-5)18-14-29)30-15-19-32(54-6)20-16-30/h7-9,11-21,23,26-27,33,35-37H,10,24-25H2,1-6H3,(H,47,51)(H,46,50,52)/t33-,35-,36-,37-,59?/m1/s1

Synonyms: 5'-O-DMTr-2'-Trifluoroacetamido-U-3'-CE-Phosphoramidite; 2'-Deoxy-2'-(N-trifluoroacetyl)amino-5'-O-DMTr-uridine 3'-CED phosphoramidite; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-[(2,2,2-trifluoroacetyl)amino]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; 2'-Amino(TFA) U amidite

N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-trifluoroacetamido-2'-deoxycytidine-3'-cyanoethyl-phosphoramidite

Description: N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-trifluoroacetamido-2'-deoxycytidine-3'-cyanoethyl-phosphoramidite is a phosphoramidite reagent used in the automated chemical synthesis of modified oligonucleotides. This compound features a 5'-dimethoxytrityl (DMTr) protecting group, a trifluoroacetamido group at the 2' position for enhanced stability and resistance to enzymatic degradation, an acetyl-protected cytosine base, and a cyanoethyl (CE) phosphoramidite group at the 3' position, facilitating the stepwise addition of nucleotides. This reagent is essential for synthesizing oligonucleotides with improved stability and specificity for therapeutic applications, such as antisense oligonucleotides and siRNAs, as well as for advanced research in nucleic acid interactions and enzymatic processes.

CAT: BRP-01543

Molecular Formula: C43H50F3N6O9P

Molecular Weight: 882.88

Purity: ≥97% by UPLC

Appearance: White or off-white to light yellow powder

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InChIKey: YKZVUVJTYKUQET-BVGHISPXSA-N

IUPAC Name: (2R,3S,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2,2,2-trifluoroacetamido)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C43H50F3N6O9P/c1-27(2)52(28(3)4)62(59-25-11-23-47)61-38-35(60-39(37(38)50-40(54)43(44,45)46)51-24-22-36(48-29(5)53)49-41(51)55)26-58-42(30-12-9-8-10-13-30,31-14-18-33(56-6)19-15-31)32-16-20-34(57-7)21-17-32/h8-10,12-22,24,27-28,35,37-39H,11,25-26H2,1-7H3,(H,50,54)(H,48,49,53,55)/t35-,37-,38-,39-,62?/m1/s1

Synonyms: 5'-O-DMTr-2'-Trifluoroacetamido-C(Ac)-3'-CE-Phosphoramidite; Cytidine, N-Acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-[(trifluoroacetyl)amino]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; 2'-Amino(TFA) C(Ac) amidite

N4-Benzoyl-5'-O-(4,4'-Dimethoxytrityl)-2'-trifluoroacetamido-2'-deoxycytidine-3'-cyanoethyl phosphoramidite

Description: N4-Benzoyl-5'-O-(4, 4'-dimethoxytrityl)-2'-trifluoroacetamido-2'-deoxycytidine-3'-cyanoethyl phosphoramidite is a phosphoramidite reagent used in the automated synthesis of modified oligonucleotides. This compound features a 5'-dimethoxytrityl (DMTr) protecting group for the 5' hydroxyl group, a trifluoroacetamido group at the 2' position to enhance stability and resistance to enzymatic degradation, a benzoyl-protected cytosine base (C(Bz)), and a cyanoethyl (CE) phosphoramidite group at the 3' position for efficient nucleotide addition during synthesis. This reagent is used to create oligonucleotides with improved stability and specificity, which are valuable for therapeutic applications such as antisense oligonucleotides and siRNAs, as well as for studying nucleic acid interactions and enzymatic processes.

CAT: BRP-01544

CAS: 176755-95-6

Molecular Formula: C48H52F3N6O9P

Molecular Weight: 944.93

Purity: ≥97% by UPLC

Appearance: White or off-white to light yellow powder

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InChIKey: KXMNUCKTZFTECT-AYACJNLVSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=CC(=NC2=O)NC(=O)C=3C=CC=CC3)C1NC(=O)C(F)(F)F)COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C

IUPAC Name: (2R,3S,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2,2,2-trifluoroacetamido)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C48H52F3N6O9P/c1-31(2)57(32(3)4)67(64-29-13-27-52)66-42-39(30-63-47(34-16-11-8-12-17-34,35-18-22-37(61-5)23-19-35)36-20-24-38(62-6)25-21-36)65-44(41(42)55-45(59)48(49,50)51)56-28-26-40(54-46(56)60)53-43(58)33-14-9-7-10-15-33/h7-12,14-26,28,31-32,39,41-42,44H,13,29-30H2,1-6H3,(H,55,59)(H,53,54,58,60)/t39-,41-,42-,44-,67?/m1/s1

Synonyms: 5'-O-DMTr-2'-Trifluoroacetamido-C(Bz)-3'-CE-Phosphoramidite; Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-[(trifluoroacetyl)amino]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; 2'-Amino(TFA) C(Bz) amidite

N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-trifluoroacetamido-2'-deoxyadenosine-3'-cyanoethyl-phosphoramidite

Description: N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-trifluoroacetamido-2'-deoxyadenosine-3'-cyanoethyl-phosphoramidite is a phosphoramidite reagent used in the automated synthesis of modified oligonucleotides. This compound includes a 5'-dimethoxytrityl (DMTr) protecting group for the 5' hydroxyl group, a trifluoroacetamido group at the 2' position to enhance stability and resistance to enzymatic degradation, a benzoyl-protected adenosine base at the N6 position, and a cyanoethyl (CE) phosphoramidite group at the 3' position for efficient nucleotide addition during synthesis. This reagent is employed to create oligonucleotides with enhanced stability and specificity, making it valuable for therapeutic applications such as antisense oligonucleotides and siRNAs, as well as for studying nucleic acid interactions and enzymatic processes.

CAT: BRP-01545

Molecular Formula: C49H52F3N8O8P

Molecular Weight: 968.97

Purity: ≥97% by UPLC

Appearance: White or off-white to light yellow powder

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InChIKey: MRKCOSUIEKSHSN-MRKXKXNLSA-N

IUPAC Name: (2R,3S,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2,2,2-trifluoroacetamido)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C49H52F3N8O8P/c1-31(2)60(32(3)4)69(66-27-13-26-53)68-42-39(28-65-48(34-16-11-8-12-17-34,35-18-22-37(63-5)23-19-35)36-20-24-38(64-6)25-21-36)67-46(40(42)57-47(62)49(50,51)52)59-30-56-41-43(54-29-55-44(41)59)58-45(61)33-14-9-7-10-15-33/h7-12,14-25,29-32,39-40,42,46H,13,27-28H2,1-6H3,(H,57,62)(H,54,55,58,61)/t39-,40-,42-,46-,69?/m1/s1

Synonyms: 5'-O-DMTr-2'-Trifluoroacetamido-A(Bz)-3'-CE-Phosphoramidite

N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-trifluoroacetamido-2'-deoxyguanosine-3'-cyanoethyl-phosphoramidite

Description: N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-trifluoroacetamido-2'-deoxyguanosine-3'-cyanoethyl-phosphoramidite is a phosphoramidite reagent used in the automated chemical synthesis of modified oligonucleotides. It features a 5'-dimethoxytrityl (DMTr) protecting group for the 5' hydroxyl group, a trifluoroacetamido group at the 2' position for enhanced stability and resistance to enzymatic degradation, an isobutyryl-protected guanosine base at the N2 position, and a cyanoethyl (CE) phosphoramidite group at the 3' position to facilitate the stepwise addition of nucleotides. This reagent is utilized to produce oligonucleotides with improved stability and specificity, making it valuable for therapeutic applications such as antisense oligonucleotides and siRNAs, as well as for advanced research in nucleic acid interactions and enzymatic processes.

CAT: BRP-01546

Molecular Formula: C46H54F3N8O9P

Molecular Weight: 950.95

Purity: ≥97% by UPLC

Appearance: White or off-white to light yellow powder

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InChIKey: KTSIVWAECVXZMP-OMTUQZFCSA-N

IUPAC Name: (2R,3S,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(2,2,2-trifluoroacetamido)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C46H54F3N8O9P/c1-27(2)40(58)54-44-53-39-37(41(59)55-44)51-26-56(39)42-36(52-43(60)46(47,48)49)38(66-67(64-24-12-23-50)57(28(3)4)29(5)6)35(65-42)25-63-45(30-13-10-9-11-14-30,31-15-19-33(61-7)20-16-31)32-17-21-34(62-8)22-18-32/h9-11,13-22,26-29,35-36,38,42H,12,24-25H2,1-8H3,(H,52,60)(H2,53,54,55,58,59)/t35-,36-,38-,42-,67?/m1/s1

Synonyms: 5'-O-DMTr-2'-Trifluoroacetamido-G(iBu)-3'-CE-Phosphoramidite

N2-Isobutyryl-5'-O-(4-methoxytrityl)-2'-fluoro-2'-deoxyguanosine-3'-cyanoethyl phosphoramidite

Description: N2-Isobutyryl-5'-O-(4-methoxytrityl)-2'-fluoro-2'-deoxyguanosine-3'-cyanoethyl Phosphoramidite plays a crucial role in oligonucleotide synthesis, enhancing stability and specificity through its chemical modifications. The 2'-fluoro substitution increases resistance to enzymatic degradation, while the N2-isobutyryl and 4-methoxytrityl protecting groups ensure precise assembly and protection during synthesis. This compound is instrumental in developing oligonucleotides with tailored properties for applications in therapeutic RNA interference (RNAi), antisense technology, and in-depth studies of nucleic acid interactions and enzymatic processes in molecular biology research.

CAT: BRP-01551

Molecular Formula: C43H51FN7O7P

Molecular Weight: 827.90

Purity: ≥98% by HPLC

Appearance: White or off-white to light yellow powder

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InChIKey: KHJOOLJXPINFLJ-WCRQIFRASA-N

CanonicalSMILES: N#CCCOP(OC1C(F)C(OC1COC(C=2C=CC=CC2)(C=3C=CC=CC3)C4=CC=C(OC)C=C4)N5C=NC=6C(=O)N=C(NC(=O)C(C)C)NC65)N(C(C)C)C(C)C

IUPAC Name: 2-cyanoethyl ((2R,3R,4R,5R)-4-fluoro-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-(((4-methoxyphenyl)diphenylmethoxy)methyl)tetrahydrofuran-3-yl) diisopropylphosphoramidite

InChI: InChI=1S/C43H51FN7O7P/c1-27(2)39(52)48-42-47-38-36(40(53)49-42)46-26-50(38)41-35(44)37(58-59(56-24-14-23-45)51(28(3)4)29(5)6)34(57-41)25-55-43(30-15-10-8-11-16-30,31-17-12-9-13-18-31)32-19-21-33(54-7)22-20-32/h8-13,15-22,26-29,34-35,37,41H,14,24-25H2,1-7H3,(H2,47,48,49,52,53)/t34-,35-,37-,41-,59?/m1/s1

Synonyms: 5'-O-MMTr-2'-F-dG(iBu) Phosphoramidite

N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxyguanosine-3'-methoxy-phosphoramidite

Description: N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxyguanosine-3'-Methoxy-phosphoramidite is a phosphoramidite reagent used in the synthesis of modified oligonucleotides. It is used in the development of modified oligonucleotides for therapeutic applications like antisense oligonucleotides and siRNAs, as well as in studies involving nucleic acid interactions, gene silencing, and RNA-based therapies.

CAT: BRP-01552

Molecular Formula: C42H52FN6O8P

Molecular Weight: 818.88

Purity: ≥98% by HPLC

Appearance: White or off-white to light yellow powder

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InChIKey: WEPASXLNAQHNEK-NNYLMNAYSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl methyl diisopropylphosphoramidite

InChI: InChI=1S/C42H52FN6O8P/c1-25(2)38(50)46-41-45-37-35(39(51)47-41)44-24-48(37)40-34(43)36(57-58(54-9)49(26(3)4)27(5)6)33(56-40)23-55-42(28-13-11-10-12-14-28,29-15-19-31(52-7)20-16-29)30-17-21-32(53-8)22-18-30/h10-22,24-27,33-34,36,40H,23H2,1-9H3,(H2,45,46,47,50,51)/t33-,34-,36-,40-,58?/m1/s1

Synonyms: 5'-O-DMTr-2'-F-dG(iBu)-3'-Methoxy-phosphoramidite; 2'-F dG(iBu) OMe-amidite; 2'-F Guanosine (n-ibu) Methoxy phosphoramidite

N6-Bz-5'-O-(4,4'-Dimethoxytrityl)-2'-fluoro-2'-deoxyadenosine-3'-methoxy-phosphoramidite

Description: N6-Bz-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxyadenosine-3'-methoxy-phosphoramidite is a specialized phosphoramidite reagent utilized in the synthesis of modified oligonucleotides. This compound features a 5'-dimethoxytrityl (DMTr) protecting group on the 5' hydroxyl group of the sugar, a 2'-fluoro modification on the deoxyribose sugar of adenine, with a benzoyl (Bz) group at the N6 position of the adenine base, and a 3'-methoxy-phosphoramidite functional group necessary for solid-phase oligonucleotide synthesis. It is valuable in developing oligonucleotides for various applications, including gene silencing (e.g., siRNAs) and therapeutic antisense oligonucleotides. Additionally, it facilitates research into nucleic acid structure, function, and interactions.

CAT: BRP-01553

Molecular Formula: C45H50FN6O7P

Molecular Weight: 836.90

Purity: ≥98% by HPLC

Appearance: White or off-white to light yellow powder

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InChIKey: NLZONZKTSFBIDR-AGYRQEKTSA-N

IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl methyl diisopropylphosphoramidite

InChI: InChI=1S/C45H50FN6O7P/c1-29(2)52(30(3)4)60(56-7)59-40-37(58-44(38(40)46)51-28-49-39-41(47-27-48-42(39)51)50-43(53)31-14-10-8-11-15-31)26-57-45(32-16-12-9-13-17-32,33-18-22-35(54-5)23-19-33)34-20-24-36(55-6)25-21-34/h8-25,27-30,37-38,40,44H,26H2,1-7H3,(H,47,48,50,53)/t37-,38-,40-,44-,60?/m1/s1

Synonyms: 5'-O-DMTr-2'-F-dA(Bz)-3'-Methoxy-phosphoramidite; 2'-F dA(Bz) OMe-amidite; 2'-F adenosine (N-Bz) Methoxy phosphoramidite

N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxycytidine-3'-methoxy-phosphoramidite

Description: N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxycytidine-3'-methoxy-phosphoramidite is a specialized phosphoramidite reagent used in the synthesis of modified oligonucleotides. This compound includes a 5'-dimethoxytrityl (DMTr) protecting group on the 5' hydroxyl group of the sugar, a 2'-fluoro modification on the deoxyribose sugar of cytosine, and an acetyl (Ac) group attached to the N4 position of the cytosine base. Additionally, it incorporates a 3'-methoxy-phosphoramidite functional group essential for solid-phase oligonucleotide synthesis. It is valuable in developing oligonucleotides for various applications, including gene expression modulation and antisense therapy. Furthermore, it supports studies exploring nucleic acid structure, function, and interactions.

CAT: BRP-01554

CAS: 1001648-84-5

Molecular Formula: C39H48FN4O8P

Molecular Weight: 750.81

Purity: ≥98% by HPLC

Appearance: White or off-white to light yellow powder

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InChIKey: IGCQRQIRQVZPMT-DJTPZYMWSA-N

CanonicalSMILES: O=C1N=C(C=CN1C2OC(COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)C(OP(OC)N(C(C)C)C(C)C)C2F)NC(=O)C

IUPAC Name: (2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl methyl diisopropylphosphoramidite

InChI: InChI=1S/C39H48FN4O8P/c1-25(2)44(26(3)4)53(49-8)52-36-33(51-37(35(36)40)43-23-22-34(41-27(5)45)42-38(43)46)24-50-39(28-12-10-9-11-13-28,29-14-18-31(47-6)19-15-29)30-16-20-32(48-7)21-17-30/h9-23,25-26,33,35-37H,24H2,1-8H3,(H,41,42,45,46)/t33-,35-,36-,37-,53?/m1/s1

Synonyms: 5'-O-DMTr-2'-F-dC(Ac)-3'-Methoxy-phosphoramidite; 2'-F-Ac-dC-3'-Methoxy-phosphoramidite; 2'-F dC(Ac) OMe-amidite; 2'-F cytidine (N-Ac) Methoxy phosphoramidite; 2'-F C(Ac) OMe-amidite; Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-, 3'-[methyl N,N-bis(1-methylethyl)phosphoramidite]

5'-O-(4,4'-Dimethoxytrityl)-2'-fluoro-2'-deoxyuridine-3'-Methoxy-phosphoramidite

Description: 5'-O-(4,4'-Dimethoxytrityl)-2'-fluoro-2'-deoxyuridine-3'-Methoxy-phosphoramidite is a specialized phosphoramidite reagent utilized in the synthesis of modified oligonucleotides. This compound features a 5'-dimethoxytrityl (DMTr) protecting group on the 5' hydroxyl group of the sugar, a 2'-fluoro modification on the deoxyribose sugar of uracil, and includes a 3'-methoxy-phosphoramidite functional group essential for solid-phase oligonucleotide synthesis. It is valuable in developing oligonucleotides for various applications, including RNA interference (RNAi), antisense therapy, and molecular diagnostics. Additionally, it supports research into nucleic acid structure, function, and interactions.

CAT: BRP-01555

CAS: 136671-61-9

Molecular Formula: C37H45FN3O8P

Molecular Weight: 709.75

Purity: ≥98% by HPLC

Appearance: White or off-white to light yellow powder

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Storage: Store at -20 °C

InChIKey: NGPNMGRLSNMJIL-DYVNLQDQSA-N

CanonicalSMILES: O=C1C=CN(C(=O)N1)C2OC(COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)C(OP(OC)N(C(C)C)C(C)C)C2F

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluorotetrahydrofuran-3-yl methyl diisopropylphosphoramidite

InChI: InChI=1S/C37H45FN3O8P/c1-24(2)41(25(3)4)50(46-7)49-34-31(48-35(33(34)38)40-22-21-32(42)39-36(40)43)23-47-37(26-11-9-8-10-12-26,27-13-17-29(44-5)18-14-27)28-15-19-30(45-6)20-16-28/h8-22,24-25,31,33-35H,23H2,1-7H3,(H,39,42,43)/t31-,33-,34-,35-,50?/m1/s1

Synonyms: 5'-O-DMTr-2'-F-dU-3'-Methoxy-phosphoramidite; 2'-F-dU-3'-Methoxy-phosphoramidite; 2'-F U OMe-amidite; 2'-F uridine methyl phosphoramidite; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-, 3'-[methyl N,N-bis(1-methylethyl)phosphoramidite]; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-, 3'-[methyl bis(1-methylethyl)phosphoramidite]

ICG-NHS

12-((2S,4R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxypyrrolidin-1-yl)-12-oxododecanoic acid

5'-DMT-PseudoUridine-CE-Phosphoramidite

5'-ODMT cEt G Phosphoramidite (Amidite)

5'-ODMT cEt m5U Phosphoramidite (Amidite)

5'-ODMT cEt N-Bz A Phosphoramidite (Amidite)

5'-ODMT cEt U Phosphoramidite (Amidite)

5'-ODMT cEt N-Bz C Phosphoramidite (Amidite)

DMT-2'-F-dG(DMF)-CE-Phosphoramidite

5-Me-5'-O-DMT-N4-Acetyl-2'-fluoro-2'-deoxy-cytidine 3'-CE phosphoramidite

5'-O-(4,4'-Dimethoxytrityl)-2'-trifluoroacetamido-2'-deoxyuridine-3'-cyanoethyl-phosphoramidite

N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-trifluoroacetamido-2'-deoxycytidine-3'-cyanoethyl-phosphoramidite

N4-Benzoyl-5'-O-(4,4'-Dimethoxytrityl)-2'-trifluoroacetamido-2'-deoxycytidine-3'-cyanoethyl phosphoramidite

N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-trifluoroacetamido-2'-deoxyadenosine-3'-cyanoethyl-phosphoramidite

N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-trifluoroacetamido-2'-deoxyguanosine-3'-cyanoethyl-phosphoramidite

N2-Isobutyryl-5'-O-(4-methoxytrityl)-2'-fluoro-2'-deoxyguanosine-3'-cyanoethyl phosphoramidite

N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxyguanosine-3'-methoxy-phosphoramidite

N6-Bz-5'-O-(4,4'-Dimethoxytrityl)-2'-fluoro-2'-deoxyadenosine-3'-methoxy-phosphoramidite

N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxycytidine-3'-methoxy-phosphoramidite

5'-O-(4,4'-Dimethoxytrityl)-2'-fluoro-2'-deoxyuridine-3'-Methoxy-phosphoramidite

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