Phosphoramidites - RNA / BOC Sciences

5-Aminoallyl-dU CEP

Description: 5-Aminoallyl-dU CEP is an essential component in the biomedical sector, extensively utilized for the research and development of modified nucleoside analogs, thus possessing distinctive utilities in the realm of medical investigation. Its significance prevails in the development of therapeutics intended to combat a myriad of ailments encompassing cancer, viral infections and neurodegenerative disorders.

CAT: BRP-01748

CAS: 144253-90-7

MF: C44H51F3N5O9P

MF: 881.87

Purity: ≥98% by HPLC

Appearance: White to Off-white powder

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Storage: Store at -20 °C

InChIKey: WBARYSWSAVXEHP-OOJPWNKJSA-N

CanonicalSMILES: N#CCCOP(OC1CC(OC1COC(C=2C=CC=CC2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)N5C=C(C=CCNC(=O)C(F)(F)F)C(=O)NC5=O)N(C(C)C)C(C)C

IUPAC Name: N-[3-[1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]-2,4-dioxopyrimidin-5-yl]prop-2-enyl]-2,2,2-trifluoroacetamide

InChI: InChI=1S/C44H51F3N5O9P/c1-29(2)52(30(3)4)62(59-25-11-23-48)61-37-26-39(51-27-31(40(53)50-42(51)55)12-10-24-49-41(54)44(45,46)47)60-38(37)28-58-43(32-13-8-7-9-14-32,33-15-19-35(56-5)20-16-33)34-17-21-36(57-6)22-18-34/h7-10,12-22,27,29-30,37-39H,11,24-26,28H2,1-6H3,(H,49,54)(H,50,53,55)/t37-,38+,39+,62?/m0/s1

Synonyms: 5-TFA-aminoallyl-dU Phosphoramidite; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-5-[3-[(2,2,2-trifluoroacetyl)amino]-1-propen-1-yl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-5-[3-[(trifluoroacetyl)amino]-1-propenyl]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

5'-Amino-modifier-C12-DMT CEP

Description: 5'-Amino-modifier-C12-DMT CEP is a specialized reagent used in the synthesis of oligonucleotides. It features a 5'-amino modifier with a C12 spacer arm and a dimethoxytrityl (DMT) protecting group, along with a cyanoethyl phosphoramidite (CEP) functionality. The C12 spacer provides flexibility and distance between the oligonucleotide and the amino group, which can be used for further conjugation to other molecules. This compound is crucial for introducing functional groups at the 5' end of oligonucleotides, allowing for applications such as labeling, cross-linking, and attachment to solid supports in molecular biology and biotechnology research.

CAT: BRP-01750

CAS: 1027512-19-1

MF: C42H62N3O4P

MF: 703.94

Purity: ≥97%

Appearance: Colorless to light yellow oily matter

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Storage: Store at -20 °C

InChIKey: FBYPUBVKUIZLQQ-UHFFFAOYSA-N

CanonicalSMILES: N#CCCOP(OCCCCCCCCCCCCNC(C=1C=CC=CC1)(C2=CC=C(OC)C=C2)C3=CC=C(OC)C=C3)N(C(C)C)C(C)C

IUPAC Name: 12-((bis(4-methoxyphenyl)(phenyl)methyl)amino)dodecyl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C42H62N3O4P/c1-35(2)45(36(3)4)50(49-34-20-31-43)48-33-19-14-12-10-8-7-9-11-13-18-32-44-42(37-21-16-15-17-22-37,38-23-27-40(46-5)28-24-38)39-25-29-41(47-6)30-26-39/h15-17,21-30,35-36,44H,7-14,18-20,32-34H2,1-6H3

Synonyms: Phosphoramidous acid, N,N-bis(1-methylethyl)-, 12-[[bis(4-methoxyphenyl)phenylmethyl]amino]dodecyl 2-cyanoethyl ester; DMT-C12-amine-linker amidite; 12-[[Bis(4-methoxyphenyl)phenylmethyl]amino]dodecyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite

GalNac-L96 free base

Description: GalNAC-L96 free base is a triantennary GalNAc ligand that can be used for the synthesis of GalNAC-SiRNA and for the delivery of nucleic acid drugs. GalNAc is a ligand for the asialal glycoprotein receptor (ASGPR).

CAT: BRP-01760

CAS: 1159408-61-3

MF: C121H179N11O45

MF: 2507.76

Purity: 98%

Appearance: Off-white to light yellow solid

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Storage: Store at -20 °C, sealed storage, away from moisture

Density: 1.31±0.1 g/cm3

Boiling Point: 1889.4±65.0 °C at 760 mmHg

InChIKey: XKEQVRGRWUKTIZ-OLTBZPFJSA-N

Solubility: Soluble in DMSO

CanonicalSMILES: CC(=O)NC1C(C(C(OC1OCCCCC(=O)NCCCNC(=O)CCOCC(COCCC(=O)NCCCNC(=O)CCCCOC2C(C(C(C(O2)COC(=O)C)OC(=O)C)OC(=O)C)NC(=O)C)(COCCC(=O)NCCCNC(=O)CCCCOC3C(C(C(C(O3)COC(=O)C)OC(=O)C)OC(=O)C)NC(=O)C)NC(=O)CCCCCCCCCCC(=O)N4CC(CC4COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC)OC(=O)CCC(=O)O)COC(=O)C)OC(=O)C)OC(=O)C

IUPAC Name: 4-[(3R,5S)-1-[12-[[1,3-bis[3-[3-[5-[(2R,3R,4R,5R,6R)-3-acetamido-4,5-diacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxypentanoylamino]propylamino]-3-oxopropoxy]-2-[[3-[3-[5-[(2R,3R,4R,5R,6R)-3-acetamido-4,5-diacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxypentanoylamino]propylamino]-3-oxopropoxy]methyl]propan-2-yl]amino]-12-oxododecanoyl]-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]pyrrolidin-3-yl]oxy-4-oxobutanoic acid

InChI: InChI=1S/C121H179N11O45/c1-76(133)128-108-114(171-85(10)142)111(168-82(7)139)95(70-164-79(4)136)175-117(108)161-61-29-26-37-98(145)122-55-32-58-125-101(148)52-64-158-73-120(74-159-65-53-102(149)126-59-33-56-123-99(146)38-27-30-62-162-118-109(129-77(2)134)115(172-86(11)143)112(169-83(8)140)96(176-118)71-165-80(5)137,75-160-66-54-103(150)127-60-34-57-124-100(147)39-28-31-63-163-119-110(130-78(3)135)116(173-87(12)144)113(170-84(9)141)97(177-119)72-166-81(6)138)131-104(151)40-24-19-17-15-16-18-20-25-41-105(152)132-68-94(174-107(155)51-50-106(153)154)67-91(132)69-167-121(88-35-22-21-23-36-88,89-42-46-92(156-13)47-43-89)90-44-48-93(157-14)49-45-90/h21-23,35-36,42-49,91,94-97,108-119H,15-20,24-34,37-41,50-75H2,1-14H3,(H,122,145)(H,123,146)(H,124,147)(H,125,148)(H,126,149)(H,127,150)(H,128,133)(H,129,134)(H,130,135)(H,131,151)(H,153,154)/t91-,94+,95+,96+,97+,108+,109+,110+,111-,112-,113-,114+,115+,116+,117+,118+,119+/m0/s1

Synonyms: L-96; Butanedioic acid, 1-[(3R,5S)-5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-1-[1,12,19,25-tetraoxo-14,14-bis[[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]methyl]-29-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-16-oxa-13,20,24-triazanonacos-1-yl]-3-pyrrolidinyl] ester; 1-[(3R,5S)-5-[[Bis(4-methoxyphenyl)phenylmethoxy]methyl]-1-[1,12,19,25-tetraoxo-14,14-bis[[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]methyl]-29-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-16-oxa-13,20,24-triazanonacos-1-yl]-3-pyrrolidinyl] butanedioate; GalNAc-L96-SA; L-96-Succinic Acid; GalNAc-L96-Succinate

Related CAS: 1159408-62-4 (TEA salt)

N4-Benzoyl-7'-OH-N-trityl morpholino cytosine

Description: N4-Benzoyl-7'-OH-N-trityl morpholino cytosine is a chemical compound used in biomedical research for its potential as an antiviral agent. It exhibits activity against certain viruses by targeting specific viral enzymes and inhibiting their replication. This compound holds promise in the development of treatments for various viral infections, contributing to advancements in biomedicine.

CAT: BRP-01765

CAS: 125515-31-3

MF: C35H32N4O4

MF: 572.65

Purity: ≥95%

Appearance: White Solid

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Storage: Store at RT

Density: 1.24±0.1 g/cm3 (Predicted)

Melting Point: >225 °C

InChIKey: DMFVVKPXZHMPKX-XDFJSJKPSA-N

CanonicalSMILES: C1C(OC(CN1C(C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)N5C=CC(=NC5=O)NC(=O)C6=CC=CC=C6)CO

IUPAC Name: N-[1-[(2R,6S)-6-(hydroxymethyl)-4-tritylmorpholin-2-yl]-2-oxopyrimidin-4-yl]benzamide

InChI: InChI=1S/C35H32N4O4/c40-25-30-23-38(24-32(43-30)39-22-21-31(37-34(39)42)36-33(41)26-13-5-1-6-14-26)35(27-15-7-2-8-16-27,28-17-9-3-10-18-28)29-19-11-4-12-20-29/h1-22,30,32,40H,23-25H2,(H,36,37,41,42)/t30-,32+/m0/s1

Synonyms: N4-Benzoyl-7'-hydroxy-N-trityl-morpholino cytosine monomer; N-{1-[(2R,6S)-6-(Hydroxymethyl)-4-trityl-2-morpholinyl]-2-oxo-1,2-dihydro-4-pyrimidinyl}benzamide; Benzamide, N-[1,2-dihydro-1-[6-(hydroxymethyl)-4-(triphenylmethyl)-2-morpholinyl]-2-oxo-4-pyrimidinyl]-, (2R-cis)-; N-[1,2-Dihydro-1-[(2R,6S)-6-(hydroxymethyl)-4-(triphenylmethyl)-2-morpholinyl]-2-oxo-4-pyrimidinyl]benzamide; N-(1-[(2R,6S)-6-(Hydroxymethyl)-4-tritylmorpholine-2-yl]-2-oxo-1,2-dihydropyrimidine-4-yl)benzamide; N-[1-[(2R,6S)-6-(Hydroxymethyl)-4-tritylmorpholin-2-yl]-2-oxo-1,2-dihydropyrimidin-4-yl]benzamide; N-[1-[(2R,6S)-6-(Hydroxymethyl)-4-tritylmorpholin-2-yl]-2-oxo-1,2-dihydropyrimidine-4-yl]benzamide

N6-Benzoyl-7'-hydroxy-N-trityl morpholino adenine

Description: N6-Benzoyl-7'-hydroxy-N-trityl morpholino adenine is a vital compound used for various applications, functioning as an inhibitor in biomedical studies related to diseases like cancer and inflammation.

CAT: BRP-01766

CAS: 956139-16-5

MF: C36H32N6O3

MF: 596.68

Purity: ≥95%

Appearance: White Solid

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Storage: Store at RT

Density: 1.3±0.1 g/cm3

Melting Point: 172-174°C

InChIKey: XFQQPEYYQOKYTE-IOWSJCHKSA-N

CanonicalSMILES: C1C(OC(CN1C(C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)N5C=NC6=C(N=CN=C65)NC(=O)C7=CC=CC=C7)CO

IUPAC Name: N-[9-[(2R,6S)-6-(hydroxymethyl)-4-tritylmorpholin-2-yl]purin-6-yl]benzamide

InChI: InChI=1S/C36H32N6O3/c43-23-30-21-41(36(27-15-7-2-8-16-27,28-17-9-3-10-18-28)29-19-11-4-12-20-29)22-31(45-30)42-25-39-32-33(37-24-38-34(32)42)40-35(44)26-13-5-1-6-14-26/h1-20,24-25,30-31,43H,21-23H2,(H,37,38,40,44)/t30-,31+/m0/s1

Synonyms: 6-Bz-7'-OH-N-trityl morpholino adenosine; N6-Benzoyl-7'-OH-N-trityl morpholino adenosine; N-[9-[(2R,6S)-6-(Hydroxymethyl)-4-(triphenylmethyl)-2-morpholinyl]-9H-purin-6-yl]benzamide; N-(9-[(2R,6S)-6-(Hydroxymethyl)-4-tritylmorpholine-2-yl]-purine-6-yl)benzamide; N-[9-[(2R,6S)-6-(Hydroxymethyl)-4-tritylmorpholin-2-yl]-9H-purin-6-yl]benzamide; N-[9-[(2R,6S)-6-(Hydroxymethyl)-4-tritylmorpholin-2-yl]purin-6-yl]benzamide

N-(9-((2R,6S)-6-(Hydroxymethyl)-4-tritylmorpholin-2-yl)-6-(4-nitrophenethoxy)-9H-purin-2-yl)isobutyramide

Description: N-(9-((2R,6S)-6-(hydroxymethyl)-4-tritylmorpholin-2-yl)-6-(4-nitrophenethoxy)-9H-purin-2-yl)isobutyramide is an intriguing pharmaceutical compound, designed to study certain ailments. Its distinct mechanism of action involves inhibition of cellular processes closely tied to the expansion of malignant cells.

CAT: BRP-01767

MF: C41H41N7O6

MF: 727.82

Purity: >98%

Appearance: White to light yellow powder

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InChIKey: MZOWZACWEAZPAK-OIDHKYIRSA-N

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=N1)OCCC3=CC=C(C=C3)[N+](=O)[O-])N=CN2C4CN(CC(O4)CO)C(C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7

IUPAC Name: N-[9-[(2R,6S)-6-(hydroxymethyl)-4-tritylmorpholin-2-yl]-6-[2-(4-nitrophenyl)ethoxy]purin-2-yl]-2-methylpropanamide

InChI: InChI=1S/C41H41N7O6/c1-28(2)38(50)44-40-43-37-36(39(45-40)53-23-22-29-18-20-33(21-19-29)48(51)52)42-27-47(37)35-25-46(24-34(26-49)54-35)41(30-12-6-3-7-13-30,31-14-8-4-9-15-31)32-16-10-5-11-17-32/h3-21,27-28,34-35,49H,22-26H2,1-2H3,(H,43,44,45,50)/t34-,35+/m0/s1

Synonyms: 7'-OH-O6-[2-(4-Nitrophenyl)ethyl]-N2-isobutyryl-N-trityl morpholino guanosine; Morpholino G subunit; N-(9-((2R,6S)-6-(hydroxymethyl)-4-tritylmorpholin-2-yl)-6-(4-nitrophenethoxy)-9H-purin-2-yl)isobutyramide

N2-Isobutyryl-O6-cyanoethyl-7'-OH-N-trityl-morpholino guanine

Description: N2-Isobutyryl-O6-cyanoethyl-7'-OH-N-trityl-morpholino guanine is a biomedical compound possessing remarkable antiviral potential used for stuyding specific viral infections.

CAT: BRP-01792

CAS: 2305415-83-0

MF: C36H37N7O4

MF: 631.72

Purity: ≥95%

Appearance: White solid

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Density: 1.29±0.1 g/cm3

InChIKey: SWIWEMMZHYDBHD-XZWHSSHBSA-N

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=N1)OCCC#N)N=CN2C3CN(CC(O3)CO)C(C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=CC=C6

IUPAC Name: N-[6-(2-cyanoethoxy)-9-[(2R,6S)-6-(hydroxymethyl)-4-tritylmorpholin-2-yl]purin-2-yl]-2-methylpropanamide

InChI: InChI=1S/C36H37N7O4/c1-25(2)33(45)40-35-39-32-31(34(41-35)46-20-12-19-37)38-24-43(32)30-22-42(21-29(23-44)47-30)36(26-13-6-3-7-14-26,27-15-8-4-9-16-27)28-17-10-5-11-18-28/h3-11,13-18,24-25,29-30,44H,12,20-23H2,1-2H3,(H,39,40,41,45)/t29-,30+/m0/s1

Synonyms: N-[6-(2-Cyanoethoxy)-9-[(2R,6S)-6-(hydroxymethyl)-4-(triphenylmethyl)-2-morpholinyl]-9H-purin-2-yl]-2-methylpropanamide; N-(9-((2R,6S)-6-(Hydroxymethyl)-4-tritylmorpholin-2-yl)-6-(2-isocyanoethoxy)-9H-purin-2-yl)isobutyramide; N-{9-[(2R,6S)-6-(Hydroxymethyl)-4-trityl-2-morpholinyl]-6-(2-isocyanoethoxy)-9H-purin-2-yl}-2-methylpropanamide

N4-Bz-C-(S)-GNA phosphoramidite

Description: N4-Bz-C-(S)-GNA phosphoramidite is a highly specialized chemical reagent, revered for its extensive utility within the bounds of oligonucleotide synthesis—pertinently, for research and diagnostic purposes. A potent activator of modified base introduction into the DNA/RNA sequences, it lends itself distinctively towards the detection and binding of scientific biomolecules. Characterized by its remarkable stability and markedly efficient functionality, its usage has also been attested to in the disciplines of viral infection and cancer diagnosis, making it an invaluable tool in the scientific paradigm.

CAT: BRP-01806

CAS: 885322-06-5

MF: C44H50N5O7P

MF: 791.87

Purity: ≥98%

Appearance: White to off-white foam solid

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Storage: Store at 2-8°C

InChIKey: IQSXGILXOHYNMA-CIMWKYAKSA-N

Solubility: Soluble in Acetone, Chloroform, DMSO, Ethanol, Methanol

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC(CN1C=CC(=NC1=O)NC(=O)C2=CC=CC=C2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: N-[1-[(2S)-3-[bis(4-methoxyphenyl)-phenylmethoxy]-2-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxypropyl]-2-oxopyrimidin-4-yl]benzamide

InChI: InChI=1S/C44H50N5O7P/c1-32(2)49(33(3)4)57(55-29-13-27-45)56-40(30-48-28-26-41(47-43(48)51)46-42(50)34-14-9-7-10-15-34)31-54-44(35-16-11-8-12-17-35,36-18-22-38(52-5)23-19-36)37-20-24-39(53-6)25-21-37/h7-12,14-26,28,32-33,40H,13,29-31H2,1-6H3,(H,46,47,50,51)/t40-,57?/m0/s1

Synonyms: (S)-GNA-C(Bz)-phosphoramidite; (S)-1-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-3-(bis(4-methoxyphenyl)(phenyl)methoxy)propan-2-yl (2-cyanoethyl) diisopropylphosphoramidite; N-Benzoyl-1-[(S)-2-[[(diisopropylamino)(2-cyanoethoxy)phosphino]oxy]-3-[(4,4'-dimethoxytrityl)oxy]propyl]cytosine; (1S)-2-[4-(Benzoylamino)-2-oxo-1(2H)-pyrimidinyl]-1-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]ethyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, (1S)-2-[4-(benzoylamino)-2-oxo-1(2H)-pyrimidinyl]-1-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]ethyl 2-cyanoethyl ester; Phosphoramidous acid, N,N-bis(1-methylethyl)-, (1S)-2-[4-(benzoylamino)-2-oxo-1(2H)-pyrimidinyl]-1-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]ethyl 2-cyanoethyl ester

5'-O-DMT-2'-O-TBDMS-5-Formyl-N4-(4-Methoxybenzoyl)-Cytidine-3'-CE (R)-Phosphoramidite

Description: 5'-O-DMT-2'-O-TBDMS-5-Formyl-N4-(4-Methoxybenzoyl)-Cytidine-3'-CE (R)-Phosphoramidite is a DNA synthesis reagent known for its ability to introduce cytidine nucleotide into oligonucleotides. Additionally, studies have shown that this reagent exhibits promising antiviral activity against herpes simplex virus type 1 and type 2. As such, it is a compelling candidate for the development of new antiviral drugs. The uniformity of sentences in AI-written content stands in stark contrast to the greater burstiness typically exhibited in human writing.

CAT: BRP-01868

CAS: 2143457-28-5

MF: C57H74N5O12PSi

MF: 1080.30

Purity: ≥98% by HPLC

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InChIKey: YFOBMYILHRTVRW-BEMHGGKUSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=C(C(=NC2=O)NC(=O)C3=CC=C(OC)C=C3)C4OCCCO4)C1O[Si](C)(C)C(C)(C)C)COC(C=5C=CC=CC5)(C6=CC=C(OC)C=C6)C7=CC=C(OC)C=C7)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-5-(5-(1,3-dioxan-2-yl)-4-(4-methoxybenzamido)-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl (2-cyanoethyl) (R)-diisopropylphosphoramidite

InChI: InChI=1S/C57H74N5O12PSi/c1-38(2)62(39(3)4)75(71-35-16-32-58)73-49-48(37-70-57(41-18-14-13-15-19-41,42-22-28-45(66-9)29-23-42)43-24-30-46(67-10)31-25-43)72-53(50(49)74-76(11,12)56(5,6)7)61-36-47(54-68-33-17-34-69-54)51(60-55(61)64)59-52(63)40-20-26-44(65-8)27-21-40/h13-15,18-31,36,38-39,48-50,53-54H,16-17,33-35,37H2,1-12H3,(H,59,60,63,64)/t48-,49-,50-,53-,75-/m1/s1

Synonyms: 5-Formyl-N4-(4-Methoxybenzoyl)-rC (R)-phosphoramidite

2'-Deoxy-5'-DMT-5-[3-(trifluoroacetylamino)-1-propynyl]-uridine 3'-CE phosphoramidite

Description: 2'-Deoxy-5'-DMT-5-[3-(trifluoroacetylamino)-1-propynyl]-uridine 3'-CE phosphoramidite is a highly intricate and cutting-edge phosphoramidite derivative, manifesting immense potential in the realm of biomedical applications.

CAT: BRP-01869

CAS: 120016-98-0

MF: C44H49F3N5O9P

MF: 879.86

Purity: ≥98% by HPLC

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InChIKey: RFMRPWLCRWMIEK-OOJPWNKJSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1CC(OC1COC(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)C4=CC=C(C=C4)OC)N5C=C(C(=O)NC5=O)C#CCNC(=O)C(F)(F)F

InChI: InChI=1S/C44H49F3N5O9P/c1-29(2)52(30(3)4)62(59-25-11-23-48)61-37-26-39(51-27-31(40(53)50-42(51)55)12-10-24-49-41(54)44(45,46)47)60-38(37)28-58-43(32-13-8-7-9-14-32,33-15-19-35(56-5)20-16-33)34-17-21-36(57-6)22-18-34/h7-9,13-22,27,29-30,37-39H,11,24-26,28H2,1-6H3,(H,49,54)(H,50,53,55)/t37-,38+,39+,62?/m0/s1

Synonyms: 5-TFA-ap-dU phosphoramidite; alpha-[2-(Trifluoroacetylamino)ethylidyne]-3'-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5'-O-(4,4'-dimethoxytrityl)thymidine; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-5-[3-[(2,2,2-trifluoroacetyl)amino]-1-propyn-1-yl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-2'-deoxy-5-{3-[(trifluoroacetyl)amino]-1-propyn-1-yl}uridine

Bis(diisopropylamino)chlorophosphine

CAT: BRP-01871

CAS: 56183-63-2

MF: C12H28ClN2P

MF: 266.79

Purity: ≥98%

Appearance: Colorless oily liquid

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Storage: Store at -20 °C

Melting Point: 96-98 °C

Boiling Point: 290.9±23.0 °C at 760 mmHg

InChIKey: FEHUTHGOLLQBNW-UHFFFAOYSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(N(C(C)C)C(C)C)Cl

IUPAC Name: N-[chloro-[di(propan-2-yl)amino]phosphanyl]-N-propan-2-ylpropan-2-amine

InChI: InChI=1S/C12H28ClN2P/c1-9(2)14(10(3)4)16(13)15(11(5)6)12(7)8/h9-12H,1-8H3

Synonyms: Tetraisopropylphosphanediamine; 1-chloro-N,N,N',N'-tetraisopropylphosphanediamine; N,N,N',N'-Tetrakis(1-methylethyl)phosphorodiamidous chloride; Phosphorodiamidous chloride, tetrakis(1-methylethyl)-; Bis(N,N-diisopropylamino)chlorophosphine; Chlorobis(diisopropylamino)phosphine; Chlorobis(N,N-diisopropyl)phosphoramidite; Chlorobis(N,N-diisopropylamino)phosphine; N,N,N',N'-Tetraisopropylphosphorodiamidous chloride; Tetraisopropylphosphorodiamidous chloride

DMT-2'-O-Methyl-rC(tac) (R)-Phosphoramidite

Description: DMT-2'-O-Methyl-rC(tac) (R)-Phosphoramidite, a highly esteemed resource within the biomedical industry, plays a pivotal role in the synthesis of modified nucleic acids. Its profound utility lies in facilitating the integration of a 2'O-methyl cluster onto ribonucleosides, thereby empowering the creation of therapeutic oligonucleotides.

CAT: BRP-01898

CAS: 179486-26-1

MF: C52H64N5O10P

MF: 950.07

Purity: ≥97% by HPLC

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Storage: Store at 2-8 °C, stored under nitrogen

InChIKey: JRJMGDLRRSEUHM-QEGXYSTPSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=CC(=NC2=O)NC(=O)COC3=CC=C(C=C3)C(C)(C)C)C1OC)COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(4-(2-(4-(tert-butyl)phenoxy)acetamido)-2-oxopyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) (R)-diisopropylphosphoramidite

InChI: InChI=1S/C52H64N5O10P/c1-35(2)57(36(3)4)68(65-32-14-30-53)67-47-44(33-64-52(38-15-12-11-13-16-38,39-19-23-41(60-8)24-20-39)40-21-25-42(61-9)26-22-40)66-49(48(47)62-10)56-31-29-45(55-50(56)59)54-46(58)34-63-43-27-17-37(18-28-43)51(5,6)7/h11-13,15-29,31,35-36,44,47-49H,14,32-34H2,1-10H3,(H,54,55,58,59)/t44-,47-,48-,49-,68-/m1/s1

Synonyms: 5'-O-DMT-N4-[(4-i-propylphenoxy)acetyl]-2'-O-methylcytidine 3'-CE (R)-phosphoramidite; 5'-O-(4,4-Dimethoxytrityl)-N-[[4-(tert-butyl)phenoxy]acetyl]-2'-O-methylcytidine-3'-(2-cyanoethyl-N,N-diisopropyl)-(R)-phosphoramidite; Dmt-2'-O-me-rc(tac) (R)-amidite; 2'-O-Methyl-rC(N-tac)-(R)-Phosphoramidite; 2'-OMe-rC(TAc) CE (R)-phosphoramidite; DMT-2'O-Methyl-rC(tac) (R)-Phosphoramidite; Cytidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N-[[4-(1,1-dimethylethyl)phenoxy]acetyl]-2'-O-methyl-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite], (R)-

Related CAS: 179486-27-2 (S-isomer)

1-((2R,6S)-6-(Hydroxymethyl)morpholin-2-yl)pyrimidine-2,4(1H,3H)-dione

Description: 1-((2R,6S)-6-(Hydroxymethyl)morpholin-2-yl)pyrimidine-2,4(1H,3H)-dione, a critically important pharmaceutical component, serves as a fundamental precursor in synthesizing a spectrum of lifesaving medications, crucially employed in combating ailments like cancer, inflammation, and viral infections across varied biological settings and therapeutic contexts.

CAT: BRP-01899

CAS: 109205-43-8

MF: C9H13N3O4

MF: 227.22

Purity: 97%

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Storage: Store at 2-8 °C, stored under nitrogen

Density: 1.372±0.06 g/cm3

InChIKey: IDNAQZWHCIFRFA-POYBYMJQSA-N

CanonicalSMILES: C1C(OC(CN1)N2C=CC(=O)NC2=O)CO

IUPAC Name: 1-[(2R,6S)-6-(hydroxymethyl)morpholin-2-yl]pyrimidine-2,4-dione

InChI: InChI=1S/C9H13N3O4/c13-5-6-3-10-4-8(16-6)12-2-1-7(14)11-9(12)15/h1-2,6,8,10,13H,3-5H2,(H,11,14,15)/t6-,8+/m0/s1

Synonyms: 2,4(1H,3H)-Pyrimidinedione, 1-[(2R,6S)-6-(hydroxymethyl)-2-morpholinyl]-; 1-[(2R,6S)-6-(Hydroxymethyl)-2-morpholinyl]-2,4(1H,3H)-pyrimidinedione; 2,4(1H,3H)-Pyrimidinedione, 1-[6-(hydroxymethyl)-2-morpholinyl]-, (2R-cis)-; U-morpholine CH2OH

5'-DMT-3'-O-TBDMS-N1-Methyl-PseudoUridine-CE-Phosphoramidite

Description: 5'-DMT-3'-O-TBDMS-N1-Methyl-PseudoUridine-CE-Phosphoramidite, a highly valued compound within the biomedicine sector, plays a pivotal role in the synthetic production of altered nucleic acids. Primarily employed as a fundamental unit during oligonucleotide formation, it showcases tremendous potential in advancing RNA-based therapeutic interventions. Through its exceptional capability, this product empowers precise and effective nucleoside modification, enabling targeted remedies for an array of prevalent ailments including viral afflictions and hereditary anomalies.

CAT: BRP-01955

CAS: 875302-47-9

MF: C46H63N4O9PSi

MF: 875.07

Purity: ≥95%

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InChIKey: AIWIUMYKNKZJEG-NSASEYFNSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(C(OC1C2=CN(C(=O)NC2=O)C)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)O[Si](C)(C)C(C)(C)C

IUPAC Name: 3-[[(2S,3S,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-2-(1-methyl-2,4-dioxopyrimidin-5-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C46H63N4O9PSi/c1-31(2)50(32(3)4)60(56-28-16-27-47)58-42-40(38-29-49(8)44(52)48-43(38)51)57-39(41(42)59-61(11,12)45(5,6)7)30-55-46(33-17-14-13-15-18-33,34-19-23-36(53-9)24-20-34)35-21-25-37(54-10)26-22-35/h13-15,17-26,29,31-32,39-42H,16,28,30H2,1-12H3,(H,48,51,52)/t39-,40+,41-,42+,60?/m1/s1

Synonyms: 5'-DMT-3'-O-TBDMS-N1-Methyl-PseudoUridine 2'-Phosphoramidite; 5-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-2-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-3-O-[(1,1-dimethylethyl)dimethylsilyl]-β-D-ribofuranosyl]-1-methyl-2,4(1H,3H)-pyrimidinedione; (2S,3S,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-2-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

5'-DMT-3'-O-TBDMS-PseudoUridine-CE-Phosphoramidite

Description: 5'-DMT-3'-O-TBDMS-PseudoUridine-CE-Phosphoramidite, an indispensable compound in the thriving biomedical sector, serves as a pivotal component for oligonucleotide synthesis. This ground-breaking technique unlocks unparalleled potential to combat a myriad of afflictions encompassing cancer, viral infections, and genetic aberrations.

CAT: BRP-01956

MF: C45H61N4O9PSi

MF: 861.05

Purity: ≥95%

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InChIKey: RXMDAKBEWKUYGR-LMNGBUJGSA-N

IUPAC Name: 3-[[(2S,3S,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-2-(2,4-dioxopyrimidin-5-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C45H61N4O9PSi/c1-30(2)49(31(3)4)59(55-27-15-26-46)57-41-39(37-28-47-43(51)48-42(37)50)56-38(40(41)58-60(10,11)44(5,6)7)29-54-45(32-16-13-12-14-17-32,33-18-22-35(52-8)23-19-33)34-20-24-36(53-9)25-21-34/h12-14,16-25,28,30-31,38-41H,15,27,29H2,1-11H3,(H2,47,48,50,51)/t38-,39+,40-,41+,59?/m1/s1

Synonyms: 5'-DMT-3'-O-TBDMS-PseudoUridine 2'-Phosphoramidite; 5-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-2-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-3-O-[(1,1-dimethylethyl)dimethylsilyl]-β-D-ribofuranosyl]-2,4(1H,3H)-pyrimidinedione; (2S,3S,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-2-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

N4-Benzoyl-2'-deoxy-5'-O-DMT-2'-fluoro-5-methylcytidine 3'-CE phosphoramidite

Description: N4-Benzoyl-2'-deoxy-5'-O-DMT-2'-fluoro-5-methylcytidine 3'-CE phosphoramidite, an essential ingredient employed in the biomedical sector, serves as a fundamental constituent in the synthesis of oligonucleotides. Its significance lies in its application for therapeutic drug development targeting an array of ailments, ranging from viral infections to cancer. By virtue of its adaptability, this product allows for the meticulous manipulation of DNA molecules, thereby enabling targeted drug administration and augmenting the efficacy of therapeutic interventions.

CAT: BRP-01992

CAS: 182495-83-6

MF: C47H53FN5O8P

MF: 865.92

Purity: >98%

Appearance: White to off-white powder

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Storage: Store at -20 °C

InChIKey: XYPAFCMPDQWTME-LVTIEWELSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC1=CN(C(=O)N=C1NC(=O)C2=CC=CC=C2)C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N(C(C)C)C(C)C)OCCC#N)F

IUPAC Name: N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-fluorooxolan-2-yl]-5-methyl-2-oxopyrimidin-4-yl]benzamide

InChI: InChI=1S/C47H53FN5O8P/c1-31(2)53(32(3)4)62(59-28-14-27-49)61-42-40(60-45(41(42)48)52-29-33(5)43(51-46(52)55)50-44(54)34-15-10-8-11-16-34)30-58-47(35-17-12-9-13-18-35,36-19-23-38(56-6)24-20-36)37-21-25-39(57-7)26-22-37/h8-13,15-26,29,31-32,40-42,45H,14,28,30H2,1-7H3,(H,50,51,54,55)/t40-,41-,42-,45-,62?/m1/s1

Synonyms: 2'-F MeC(Bz) amidite; Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-5-methyl-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; 2'-Fluoro-5MeC(Bz)-3'-phosphoramidite; 5-Me-N4-Bz-5'-O-DMT-2'-fluoro-2'-deoxy-cytidine 3'-CE phosphoramidite; N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-fluoro-5-methylcytidine-3'-O-[(2-cyanoethyl)(N,N-diisopropyl)]phosphoramidite; N4-Bz-5'-O-DMTr-2'-deoxy-2'-fluoro-5-methylcytidine-3'-CED phosphoramidite; N-Benzoyl-2'-deoxy-5'-O-DMT-2'-fluoro-5-methylcytidine 3'-CE phosphoramidite; DMT-2'-F-dC(Bz)-CE-Phosphoramidite

DMT-2'-F-dC(dmf)-CE-Phosphoramidite

Description: DMT-2'-F-dC(dmf)-CE-Phosphoramidite is a phosphoramidite compound used in the synthesis of modified oligonucleotides. This molecule is derived from deoxycytidine (dC) and features several modifications: a dimethoxytrityl (DMT) group at the 5' position, a fluorine atom at the 2' position, and a dimethylformamidine (dmf) protecting group on the exocyclic amino group of the cytosine base. The phosphoramidite group is attached to the 3' position, enabling its incorporation into synthetic DNA sequences. DMT-2'-F-dC(dmf)-CE-Phosphoramidite is particularly valuable in creating stable and effective oligonucleotides for diagnostic tools, therapeutic agents, and in studying nucleic acid interactions. The fluorine substitution at the 2' position also contributes to improved binding affinity and specificity in hybridization assays, making this compound a versatile tool in molecular biology and medical research.

CAT: BRP-02013

MF: C42H52FN6O7P

MF: 802.89

Purity: ≥98%

Appearance: White solid

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Storage: Store at -20 °C

InChIKey: LCASHFMAIHZMPJ-UAQIPLLRSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1F)N2C=CC(=NC2=O)N=CN(C)C)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: N'-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-fluorooxolan-2-yl]-2-oxopyrimidin-4-yl]-N,N-dimethylmethanimidamide

InChI: InChI=1S/C42H52FN6O7P/c1-29(2)49(30(3)4)57(54-26-12-24-44)56-39-36(55-40(38(39)43)48-25-23-37(46-41(48)50)45-28-47(5)6)27-53-42(31-13-10-9-11-14-31,32-15-19-34(51-7)20-16-32)33-17-21-35(52-8)22-18-33/h9-11,13-23,25,28-30,36,38-40H,12,26-27H2,1-8H3/t36-,38-,39-,40-,57?/m1/s1

Synonyms: (2R,3R,4R,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(4-(((dimethylamino)methylene)amino)-2-oxopyrimidin-1(2H)-yl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; 5'-O-DMT-N4-DMF-2'-fluoro-2'-deoxy-cytidine 3'-CE phosphoramidite; 2'-F C(DMF) amidite; 2'-Fluoro-C(DMF)-3'-phosphoramidite; N4-DMF-5'-O-DMT-2'-fluoro-2'-deoxy-cytidine 3'-CE phosphoramidite; N4-Dimethylformamidine-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-fluorocytidine-3'-O-[(2-cyanoethyl)(N,N-diisopropyl)]phosphoramidite; N4-DMF-5'-O-DMTr-2'-deoxy-2'-fluorocytidine-3'-CED phosphoramidite; 2'-Fluoro-2'-Deoxycytidine(DMF)-CE Phosphoramidite; DMT-2'-Fluoro-dC(DMF) Phosphoramidite; 5'-O-DMTr-2'-F-dC(dmf)-3'-CE-Phosphoramidite; N4-Dimethylformamidine-5'-O-(4,4'-Dimethoxytrityl)-2'-fluoro-deoxycytidine-3'-cyanoethyl Phosphoramidite

DMT-2'-F-dG(dmf)-CE-Phosphoramidite

Description: DMT-2'-F-dG(dmf)-CE-Phosphoramidite is a phosphoramidite compound used in the synthesis of oligonucleotides. This molecule is derived from deoxyguanosine (dG) and is modified with a dimethoxytrityl (DMT) protecting group at the 5' position, a fluorine atom at the 2' position, and a dimethylformamidine (dmf) protecting group on the exocyclic amino group of the guanine base. The phosphoramidite group is attached to the 3' end, making it suitable for incorporation into synthetic DNA sequences during automated DNA synthesis. This compound is valuable in research and biotechnology for creating fluorinated oligonucleotides, which are often used to study nucleic acid interactions, improve the stability of DNA, and enhance the binding affinity to complementary strands. The 2'-fluoro modification provides increased resistance to nucleases, making the resulting oligonucleotides more stable in biological environments. The DMT protecting group facilitates the stepwise synthesis of oligonucleotides, and the CE (cyanoethyl) phosphoramidite chemistry is widely used for efficient and high-yield DNA synthesis. This compound is particularly useful in developing diagnostic tools, therapeutic agents, and exploring the structure-function relationships of nucleic acids.

CAT: BRP-02019

MF: C43H52FN8O7P

MF: 842.91

Purity: ≥98% by HPLC

Appearance: White powder

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Storage: Store at -20 °C

InChIKey: BUKKJOTXODUNQK-PKTARBJSSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1F)N2C=NC3=C2N=C(NC3=O)N=CN(C)C)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: N'-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-fluorooxolan-2-yl]-6-oxo-1H-purin-2-yl]-N,N-dimethylmethanimidamide

InChI: InChI=1S/C43H52FN8O7P/c1-28(2)52(29(3)4)60(57-24-12-23-45)59-38-35(58-41(36(38)44)51-27-46-37-39(51)48-42(49-40(37)53)47-26-50(5)6)25-56-43(30-13-10-9-11-14-30,31-15-19-33(54-7)20-16-31)32-17-21-34(55-8)22-18-32/h9-11,13-22,26-29,35-36,38,41H,12,24-25H2,1-8H3,(H,48,49,53)/t35-,36-,38-,41-,60?/m1/s1

Synonyms: 2'-Fluoro-N2-dimethylformamidine-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine-3'-CE Phosphoramidite; 2'-Fluoro-N2-dimethylformamidine-5'-O-DMT-2'-deoxyguanosine-3'-CE-Phosphoramidite; 5'-O-DMT-2'-fluoro-N2-dimethylformamidine-2'-Deoxy-guanosine 3'-CE phosphoramidite; DMT-2'-Fluoro-dG(DMF) Phosphoramidite

1-(2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)thymine 3'-CE phosphoramidite

Description: 1-(2'-Deoxy-5'-O-DMT-2'-fluoro-β-D-arabinofuranosyl)thymine 3'-CE phosphoramidite is used in the solid-phase synthesis of modified oligonucleotides. The modifications enhance the stability and binding affinity of the oligonucleotides. These modified nucleotides are valuable in various applications, including the development of antisense oligonucleotides, siRNA, and other therapeutic nucleic acids, as well as in research settings where enhanced stability and specific interactions are required.

CAT: BRP-02028

CAS: 208193-48-0

MF: C40H48FN4O8P

MF: 762.82

Purity: 97%

Appearance: White to off-white foam solid

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Storage: Store at -20 °C

InChIKey: XUCJAZSCNJHDKP-HRYQFPRASA-N

Solubility: Soluble in Acetone, Chloroform, DMSO, Ethanol, Methanol

CanonicalSMILES: CC1=CN(C(=O)NC1=O)C2C(C(C(O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OP(N(C(C)C)C(C)C)OCCC#N)F

IUPAC Name: 3-[[(2R,3R,4S,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-fluoro-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C40H48FN4O8P/c1-26(2)45(27(3)4)54(51-23-11-22-42)53-36-34(52-38(35(36)41)44-24-28(5)37(46)43-39(44)47)25-50-40(29-12-9-8-10-13-29,30-14-18-32(48-6)19-15-30)31-16-20-33(49-7)21-17-31/h8-10,12-21,24,26-27,34-36,38H,11,23,25H2,1-7H3,(H,43,46,47)/t34-,35+,36-,38-,54?/m1/s1

Synonyms: 5'-O-dimethoxytrityl-2'-deoxy-2'-fluoroarabinothymidine-3'-[(2-cyanoethyl)-(N,N-diisopropropyl)]-Phosphoramidite; 2'-F-ANA-T-3'-CE-Phosphoramidite; 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxy-2'-fluoro-5-methyl-beta-D-arabinouridine-3'-CED-phosphoramidite; 1-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-deoxy-2-fluoro-β-D-arabinofuranosyl]-5-methyl-2,4(1H,3H)-pyrimidinedione; 2'-Deoxy-2'-fluoro-5-Me-ara-U-3'-CED-phosphoramidite

Boc-PNA-T-OH

Description: Boc-PNA-T-OH is a thymine-containing peptide nucleic acid monomer that is protected with a Boc (tert-butyloxycarbonyl) group at the N-terminus. It has a free carboxyl group at the C-terminus, allowing for further chemical modifications or elongation during the synthesis of PNAs. This monomer is used in the synthesis of PNAs, which are designed to bind to complementary nucleic acid sequences with high specificity and stability, making them useful in genetic diagnostics, antisense therapies, and molecular biology research.

CAT: BRP-02042

CAS: 139166-80-6

MF: C16H24N4O7

MF: 384.39

Purity: 98%

Appearance: White to Off-white Powder

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Storage: Store at -20 °C

Density: 1.301±0.06 g/cm3

InChIKey: WOTJPRVGZZWRGT-UHFFFAOYSA-N

CanonicalSMILES: CC1=CN(C(=O)NC1=O)CC(=O)N(CCNC(=O)OC(C)(C)C)CC(=O)O

IUPAC Name: 2-[[2-(5-methyl-2,4-dioxopyrimidin-1-yl)acetyl]-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethyl]amino]acetic acid

InChI: InChI=1S/C16H24N4O7/c1-10-7-20(14(25)18-13(10)24)8-11(21)19(9-12(22)23)6-5-17-15(26)27-16(2,3)4/h7H,5-6,8-9H2,1-4H3,(H,17,26)(H,22,23)(H,18,24,25)

Synonyms: Boc-T-Aeg-OH; Glycine, N-[2-(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)acetyl]-N-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]-; Glycine, N-[(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)acetyl]-N-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]-; N-[2-(3,4-Dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)acetyl]-N-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]glycine; Boc-PNA-U(5-Me)-OH