Phosphoramidites

Description: Polyethyleneglycol 2000 CED phosphoramidite is a specialized compound used in oligonucleotide synthesis. It consists of a polyethylene glycol (PEG) chain with a molecular weight of 2000 Da, modified with a 5'-cyanoethyl (CED) phosphoramidite functionality. This compound serves as a linker or spacer molecule, aiding in the conjugation or attachment of oligonucleotides to various biomolecules or surfaces. The PEG chain provides flexibility and water solubility, while the CED phosphoramidite allows controlled addition during synthesis, facilitating the synthesis of PEGylated oligonucleotides for various biomedical and biotechnological applications, such as drug delivery systems or diagnostics.

CAT: BRP-01466

Molecular Formula: C120H217N2O49P

Molecular Weight: 2502.96

Description: DMT-nonane-Diol phosphoramidite is a specialized compound used in oligonucleotide synthesis. It serves as a phosphitylating reagent for introducing nucleotide phosphoramidites onto solid supports during oligonucleotide assembly. This compound features a nonyl chain with a bis(4-methoxyphenyl)(phenyl)methoxy group attached, along with a 2-cyanoethyl group and diisopropylphosphoramidite functionality. Its role in oligonucleotide synthesis involves controlled addition to the growing oligonucleotide chain, allowing for precise sequence design and customization for various molecular biology applications.

CAT: BRP-01467

CAS: 146669-12-7

Molecular Formula: C39H55N2O5P

Molecular Weight: 662.84

Description: 5-TAMRA CED phosphoramidite is a specialized compound employed in oligonucleotide synthesis, particularly for labeling nucleic acids. TAMRA (5-carboxytetramethylrhodamine) is a commonly used fluorescent dye that is conjugated to the 5' end of oligonucleotides for various applications such as fluorescence resonance energy transfer (FRET), fluorescence in situ hybridization (FISH), and real-time PCR. The CED (5'-cyanoethyl) phosphoramidite moiety enables controlled addition of the TAMRA-labeled nucleotide during oligonucleotide synthesis, allowing for precise customization and synthesis of labeled oligonucleotides for molecular biology and biotechnology research purposes.

CAT: BRP-01468

CAS: 321862-13-9

Molecular Formula: C39H48N5O6P

Molecular Weight: 713.82

Description: 2'-tBDSilyl Guanosine (N-PAC) CED phosphoramidite is a specialized nucleotide compound used in oligonucleotide synthesis. It consists of a guanosine nucleoside modified with a 2'-tert-butyldimethylsilyl (tBDSilyl) group to protect the 2'-hydroxyl position. Additionally, it features a phenoxyacetyl (PAC) group attached to the amine group of the guanosine base. Furthermore, it contains a 5'-cyanoethyl (CED) phosphoramidite functionality, enabling controlled addition during oligonucleotide synthesis. This compound facilitates stable and precise synthesis of customized oligonucleotides, crucial for various molecular biology research applications such as PCR, sequencing, and gene expression analysis.

CAT: BRP-01475

CAS: 121058-87-5

Molecular Formula: C54H68N7O10PSi

Molecular Weight: 1034.22

Description: 5'-O-DMT-2'-O-TBDMS-5-Formyl-N4-(4-Methoxybenzoyl)-Cytidine-3'-CE Phosphoramidite is a chemically modified nucleoside used in the synthesis of oligonucleotides. These modifications protect the nucleoside during synthesis and can be selectively removed to yield the desired oligonucleotide.

CAT: BRP-01498

Molecular Formula: C57H74N5O12PSi

Molecular Weight: 1080.29

Description: DMT-2'-O-Methyl-rC(tac) Phosphoramidite is a modified phosphoramidite designed for the synthesis of stable and efficient RNA oligonucleotides. The protective groups and modifications, such as 5'-O-DMTr and 2'-O-methyl, enhance the stability of the resulting nucleic acids and facilitate their incorporation into nucleic acid chains during solid-phase synthesis. This compound is crucial in producing antisense oligonucleotides, siRNA, probes, and primers, providing enhanced resistance to enzymatic degradation and improved performance in various applications.

CAT: BRP-01499

Molecular Formula: C52H64N5O10P

Molecular Weight: 950.08

Purity: ≥95% by HPLC

Description: [5'-O-DMTr-2'-OMe-C(Ac)](pCyEt)[2'-F-dG(iBu)-3'-CE-Phosphoramidite] is a specialized building block for synthesizing chemically modified oligonucleotides. These modifications improve the properties of nucleic acids for research and therapeutic purposes, such as increased stability, specificity, and resistance to degradation. This compound is crucial in the fields of biochemical research and therapeutic development, contributing to advancements in genetic and molecular medicine.

CAT: BRP-01504

Molecular Formula: C59H72FN11O16P2

Molecular Weight: 1272.21

Purity: ≥97% by HPLC

Appearance: White, off-white to faint yellow powder

Description: [5'-O-DMTr-2'-OMe-U](pCyEt)[2'-F-dA(Bz)-3'-CE-Phosphoramidite] is a modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of a 5'-O-DMTr-2'-OMe-uridine, coupled with a 2'-fluoro-deoxyadenosine (2'-F-dA) featuring a benzoyl (Bz) protecting group. These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making it valuable for biochemical research and therapeutic applications.

CAT: BRP-01505

Molecular Formula: C60H67FN10O15P2

Molecular Weight: 1249.20

Purity: ≥97% by HPLC

Appearance: White, off-white to faint yellow powder

Description: [5'-O-DMTr-2'-OMe-C(Ac)](pCyEt)[2'-F-dU-3'-CE-Phosphoramidite] is a modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of a 5'-O-DMTr-2'-OMe-cytidine with an acetyl (Ac) protecting group, coupled with a 2'-fluoro-deoxyuridine (2'-F-dU). These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making it valuable for biochemical research and therapeutic applications.

CAT: BRP-01506

Molecular Formula: C54H65FN8O16P2

Molecular Weight: 1163.10

Purity: ≥97% by HPLC

Appearance: White, off-white to faint yellow powder

Description: [5'-O-DMTr-2'-F-dA(Bz)](pCyEt)[2'-F-dU-3'-CE-Phosphoramidite] is a modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of a 5'-O-DMTr-2'-fluoro-deoxyadenosine (2'-F-dA) with a benzoyl (Bz) protecting group, coupled with a 2'-fluoro-deoxyuridine (2'-F-dU). These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making it valuable for biochemical research and therapeutic applications.

CAT: BRP-01507

Molecular Formula: C59H64F2N10O14P2

Molecular Weight: 1237.16

Purity: ≥97% by HPLC

Appearance: White, off-white to faint yellow powder

Description: [5'-O-DMTr-2'-OMe-A(Bz)](P-thio-pCyEt) [2'-F-dG(iBu)-3'-CE-Phosphoramidite] is a modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of a 5'-O-DMTr-2'-OMe-adenosine with a benzoyl (Bz) protecting group, coupled with a 2'-fluoro-deoxyguanosine (2'-F-dG) featuring an isobutyryl (iBu) protecting group. These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making it valuable for biochemical research and therapeutic applications.

CAT: BRP-01508

Molecular Formula: C65H74FN13O14P2S

Molecular Weight: 1374.39

Purity: ≥97% by HPLC

Appearance: White, off-white to faint yellow powder

Description: [5'-O-DMTr-2'-F-dA(Bz)](P-thio-pCyEt) [2'-OMe-U-3'-CE-Phosphoramidite] is a modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of a 5'-O-DMTr-2'-fluoro-deoxyadenosine (2'-F-dA) with a benzoyl (Bz) protecting group, coupled with a 2'-O-Me-uridine. These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making it valuable for biochemical research and therapeutic applications.

CAT: BRP-01509

Molecular Formula: C60H67FN10O14P2S

Molecular Weight: 1265.26

Purity: ≥97% by HPLC

Appearance: White, off-white to faint yellow powder

Description: [5'-O-DMTr-2'-OMe-G(iBu)](pCyEt)[2'-OMe-U](pCyEt)[2'-OMe-A(Bz)-3'-CE-Phosphoramidite] is a complex modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of three sequentially linked nucleosides: a 5'-O-DMTr-2'-OMe-guanosine (G) with an isobutyryl (iBu) protecting group, a 2'-OMe-uridine (U), and a 2'-OMe-adenosine (A) with a benzoyl (Bz) protecting group. Each linkage is protected by a cyanoethyl (CE) group, ensuring stability during synthesis. These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making them valuable for advanced biochemical research and therapeutic applications.

CAT: BRP-01510

Molecular Formula: C79H93N16O24P3

Molecular Weight: 1743.62

Purity: ≥90% by HPLC

Appearance: White, off-white to faint yellow powder

Description: [5'-O-DMTr-2'-OMe-A(Bz)](pCyEt)[2'-OMe-U](pCyEt)[2'-OMe-A(Bz)-3'-CE-Phosphoramidite] is a complex modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of three sequentially linked nucleosides: a 5'-O-DMTr-2'-O-methyl-adenosine (2'-OMe-A) with a benzoyl (Bz) protecting group, a 2'-O-methyl-uridine (2'-OMe-U), and another 2'-O-methyl-adenosine (2'-OMe-A) with a benzoyl (Bz) protecting group. Each linkage is protected by a cyanoethyl (CE) group, ensuring stability during synthesis. These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making them valuable for advanced biochemical research and therapeutic applications.

CAT: BRP-01511

Molecular Formula: C82H91N16O23P3

Molecular Weight: 1761.64

Purity: ≥90% by HPLC

Appearance: White, off-white to faint yellow powder

Description: [5'-O-DMTr-2'-F-dC(Ac)](pCyEt)[2'-F-dC(Ac)](pCyEt)[2'-F-dA(Bz)-3'-CE-Phosphoramidite] is a complex modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of three sequentially linked nucleosides: a 5'-O-DMTr-2'-fluoro-deoxycytidine (2'-F-dC) with an acetyl (Ac) protecting group, a second 2'-fluoro-deoxycytidine (2'-F-dC) with an acetyl (Ac) protecting group, and a 2'-fluoro-deoxyadenosine (2'-F-dA) with a benzoyl (Bz) protecting group. Each linkage is protected by a cyanoethyl (CE) group, ensuring stability during synthesis. These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making them valuable for advanced biochemical research and therapeutic applications.

CAT: BRP-01512

Molecular Formula: C75H83F3N15O21P3

Molecular Weight: 1680.49

Purity: ≥90% by HPLC

Appearance: White, off-white to faint yellow powder

Description: [5'-O-DMTr-2'-OMe-C(Ac)](P-thio-pCyEt)[2'-OMe-A(Bz)](P-thio-pCyEt)[2'-OMe-G(iBu)-3'-CE-Phosphoramidite] is a complex modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of three sequentially linked nucleosides: a 5'-O-DMTr-2'-O-methyl-cytidine (2'-OMe-C) with an acetyl (Ac) protecting group, a 2'-O-methyl-adenosine (2'-OMe-A) with a benzoyl (Bz) protecting group, and a 2'-O-methyl-guanosine (2'-OMe-G) with an isobutyryl (iBu) protecting group. Each linkage is protected by a phosphorothioate (P-thio) group and a cyanoethyl (CE) group, ensuring stability during synthesis. These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making them valuable for advanced biochemical research and therapeutic applications.

CAT: BRP-01513

Molecular Formula: C81H96N17O22P3S2

Molecular Weight: 1816.80

Purity: ≥90% by HPLC

Appearance: White, off-white to faint yellow powder

Description: [5'-O-DMTr-2'-OMe-U](pCyEt)[2'-OMe-A(Bz)](pCyEt)[2'-OMe-A(Bz)-3'-CE-Phosphoramidite] is a complex modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of three sequentially linked nucleosides: a 5'-O-DMTr-2'-O-methyl-uridine (2'-OMe-U), a 2'-O-methyl-adenosine (2'-OMe-A) with a benzoyl (Bz) protecting group, and another 2'-O-methyl-adenosine (2'-OMe-A) with a benzoyl (Bz) protecting group. Each linkage is protected by a cyanoethyl (CE) group, ensuring stability during synthesis. These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making them valuable for advanced biochemical research and therapeutic applications.

CAT: BRP-01514

Molecular Formula: C82H91N16O23P3

Molecular Weight: 1761.64

Purity: ≥90% by HPLC

Appearance: White, off-white to faint yellow powder

Description: DMTr-O Diethyleneglycol Phosphoramidite is a phosphoramidite reagent used in solid-phase oligonucleotide synthesis. This phosphoramidite facilitates the efficient and controlled synthesis of oligonucleotides with high purity. The bulky protecting groups on the backbone provide stability during synthesis and can be selectively removed during deprotection steps. This reagent is commonly used in automated oligonucleotide synthesis for various molecular biology and biotechnology applications.

CAT: BRP-01515

CAS: 362013-57-8

Molecular Formula: C34H45N2O6P

Molecular Weight: 608.72

Description: 5'-Cholesterol PEG5-CE Phosphoramidite is a modified phosphoramidite used in oligonucleotide synthesis to introduce a cholesterol moiety and a PEG (polyethylene glycol) spacer at the 5' end of the oligonucleotide. This modification enhances the stability, solubility, and cellular uptake of the oligonucleotide, making it useful for various applications such as antisense therapy, siRNA, and molecular probes.

CAT: BRP-01516

Molecular Formula: C46H83N2O7P

Molecular Weight: 807.15

Description: 5'-Biotin Phosphoramidite is a modified phosphoramidite used in oligonucleotide synthesis to introduce a biotin molecule at the 5' end of the oligonucleotide. Introducing biotin at the 5' end allows for easy conjugation of the oligonucleotide to streptavidin or avidin, enabling applications like DNA/RNA labeling, pull-down assays, detection of nucleic acid hybridization, and immobilization of oligonucleotides onto solid supports.

CAT: BRP-01517

CAS: 1807503-79-2

Molecular Formula: C46H64N5O6PS

Molecular Weight: 846.08

Purity: ≥95%