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2'-Modified Phosphoramidites
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[2'-f-da(bz)-3'-ce-phosphoramidite].gif)
[5'-O-DMTr-2'-OMe-U](pCyEt)[2'-F-dA(Bz)-3'-CE-Phosphoramidite]
Description: [5'-O-DMTr-2'-OMe-U](pCyEt)[2'-F-dA(Bz)-3'-CE-Phosphoramidite] is a modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of a 5'-O-DMTr-2'-OMe-uridine, coupled with a 2'-fluoro-deoxyadenosine (2'-F-dA) featuring a benzoyl (Bz) protecting group. These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making it valuable for biochemical research and therapeutic applications.
CAT: BRP-01505
Molecular Formula: C60H67FN10O15P2
Molecular Weight: 1249.20
Purity: ≥97% by HPLC
Appearance: White, off-white to faint yellow powder
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | -- | -- |
Storage: Store at -20 °C
InChIKey: FFDBGFAJQMQYDB-YJAGKEHNSA-N
IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C60H67FN10O15P2/c1-38(2)71(39(3)4)87(80-32-14-29-62)85-51-47(83-57(49(51)61)70-37-66-50-54(64-36-65-55(50)70)68-56(73)40-16-10-8-11-17-40)35-82-88(75,81-33-15-30-63)86-52-46(84-58(53(52)78-7)69-31-28-48(72)67-59(69)74)34-79-60(41-18-12-9-13-19-41,42-20-24-44(76-5)25-21-42)43-22-26-45(77-6)27-23-43/h8-13,16-28,31,36-39,46-47,49,51-53,57-58H,14-15,32-35H2,1-7H3,(H,67,72,74)(H,64,65,68,73)/t46-,47-,49-,51-,52-,53-,57-,58-,87?,88?/m1/s1
Synonyms: [5'-O-(4,4'-dimethoxytrityl)-2'-O-methyluridine](pCyEt)[2'-Fluoro-deoxy-A(benzoyl)-3'-cyanoethyl-Phosphoramidite]; UmAf; [5'-O-DMTr-2'-OMe-U](pCyEt)[2'-F-A(Bz)-3'-CE Phosphoramidite]
](pcyet)[2'-f-du-3'-ce-phosphoramidite].gif)
[5'-O-DMTr-2'-OMe-C(Ac)](pCyEt)[2'-F-dU-3'-CE-Phosphoramidite]
Description: [5'-O-DMTr-2'-OMe-C(Ac)](pCyEt)[2'-F-dU-3'-CE-Phosphoramidite] is a modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of a 5'-O-DMTr-2'-OMe-cytidine with an acetyl (Ac) protecting group, coupled with a 2'-fluoro-deoxyuridine (2'-F-dU). These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making it valuable for biochemical research and therapeutic applications.
CAT: BRP-01506
Molecular Formula: C54H65FN8O16P2
Molecular Weight: 1163.10
Purity: ≥97% by HPLC
Appearance: White, off-white to faint yellow powder
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | -- | -- |
Storage: Store at -20 °C
InChIKey: KDSLXRMSXDHYPC-JFJKBCMNSA-N
IUPAC Name: (2R,3R,4R,5R)-2-((((((2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C54H65FN8O16P2/c1-34(2)63(35(3)4)80(73-30-12-26-56)78-47-43(76-50(46(47)55)61-29-25-45(65)60-53(61)67)33-75-81(68,74-31-13-27-57)79-48-42(77-51(49(48)71-8)62-28-24-44(58-36(5)64)59-52(62)66)32-72-54(37-14-10-9-11-15-37,38-16-20-40(69-6)21-17-38)39-18-22-41(70-7)23-19-39/h9-11,14-25,28-29,34-35,42-43,46-51H,12-13,30-33H2,1-8H3,(H,60,65,67)(H,58,59,64,66)/t42-,43-,46-,47-,48-,49-,50-,51-,80?,81?/m1/s1
Synonyms: [5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-C(acetyl)](pCyEt)[2'-O-Me-U-3'-cyanoethyl-Phosphoramidite]; CmUf; [5'-O-DMTr-2'-OMe C(Ac)](pCyEt)[2'-F-U-3'-CE Phosphoramidite]
](pcyet)[2'-f-du-3'-ce-phosphoramidite].gif)
[5'-O-DMTr-2'-F-dA(Bz)](pCyEt)[2'-F-dU-3'-CE-Phosphoramidite]
Description: [5'-O-DMTr-2'-F-dA(Bz)](pCyEt)[2'-F-dU-3'-CE-Phosphoramidite] is a modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of a 5'-O-DMTr-2'-fluoro-deoxyadenosine (2'-F-dA) with a benzoyl (Bz) protecting group, coupled with a 2'-fluoro-deoxyuridine (2'-F-dU). These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making it valuable for biochemical research and therapeutic applications.
CAT: BRP-01507
Molecular Formula: C59H64F2N10O14P2
Molecular Weight: 1237.16
Purity: ≥97% by HPLC
Appearance: White, off-white to faint yellow powder
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|---|---|---|---|
| -- | -- | -- |
Storage: Store at -20 °C
InChIKey: FRHVJBZWLACXPX-PXRYCWEGSA-N
IUPAC Name: (2R,3R,4R,5R)-2-((((((2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C59H64F2N10O14P2/c1-37(2)71(38(3)4)86(79-31-13-28-62)84-51-46(83-56(48(51)60)69-30-27-47(72)67-58(69)74)34-81-87(75,80-32-14-29-63)85-52-45(82-57(49(52)61)70-36-66-50-53(64-35-65-54(50)70)68-55(73)39-15-9-7-10-16-39)33-78-59(40-17-11-8-12-18-40,41-19-23-43(76-5)24-20-41)42-21-25-44(77-6)26-22-42/h7-12,15-27,30,35-38,45-46,48-49,51-52,56-57H,13-14,31-34H2,1-6H3,(H,67,72,74)(H,64,65,68,73)/t45-,46-,48-,49-,51-,52-,56-,57-,86?,87?/m1/s1
Synonyms: [5'-O-(4,4'-dimethoxytrityl)-2'-Fluoro-deoxyadenosine(benzoyl)](pCyEt)[2'-Fluoro-deoxy-U-3'-cyanoethyl-Phosphoramidite]; AfUf; [5'-O-DMTr-2'-F-dA(Bz)](pCyEt)[2'-F-U-3'-CE Phosphoramidite]
](p-thio-pcyet)-[2'-f-dg(ibu)-3'-ce-phosphoramidite].gif)
[5'-O-DMTr-2'-OMe-A(Bz)](P-thio-pCyEt) [2'-F-dG(iBu)-3'-CE-Phosphoramidite]
Description: [5'-O-DMTr-2'-OMe-A(Bz)](P-thio-pCyEt) [2'-F-dG(iBu)-3'-CE-Phosphoramidite] is a modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of a 5'-O-DMTr-2'-OMe-adenosine with a benzoyl (Bz) protecting group, coupled with a 2'-fluoro-deoxyguanosine (2'-F-dG) featuring an isobutyryl (iBu) protecting group. These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making it valuable for biochemical research and therapeutic applications.
CAT: BRP-01508
Molecular Formula: C65H74FN13O14P2S
Molecular Weight: 1374.39
Purity: ≥97% by HPLC
Appearance: White, off-white to faint yellow powder
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | -- | -- |
Storage: Store at -20 °C
InChIKey: DQOIBMFRYZHGJO-UMYUGCJYSA-N
IUPAC Name: (2R,3R,4R,5R)-2-((((((2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphorothioyl)oxy)methyl)-4-fluoro-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C65H74FN13O14P2S/c1-39(2)59(80)75-64-74-58-52(61(82)76-64)72-38-78(58)62-50(66)53(92-94(87-32-16-30-67)79(40(3)4)41(5)6)49(90-62)35-89-95(96,88-33-17-31-68)93-54-48(91-63(55(54)85-9)77-37-71-51-56(69-36-70-57(51)77)73-60(81)42-18-12-10-13-19-42)34-86-65(43-20-14-11-15-21-43,44-22-26-46(83-7)27-23-44)45-24-28-47(84-8)29-25-45/h10-15,18-29,36-41,48-50,53-55,62-63H,16-17,32-35H2,1-9H3,(H,69,70,73,81)(H2,74,75,76,80,82)/t48-,49-,50-,53-,54-,55-,62-,63-,94?,95?/m1/s1
Synonyms: [5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-A(benzoyl)](P-thio-pCyEt) [2'-Fluoro-deoxy-G(isobutyryl)-3'-cyanoethyl-Phosphoramidite]; AmsGf; [5'-O-DMTr-2'-OMe-dA(Bz)](P thio-pCyEt)[2'-F-G(ibu)-3'-CE Phosphoramidite
](p-thio-pcyet)-[2'-ome-u-3'-ce-phosphoramidite].gif)
[5'-O-DMTr-2'-F-dA(Bz)](P-thio-pCyEt) [2'-OMe-U-3'-CE-Phosphoramidite]
Description: [5'-O-DMTr-2'-F-dA(Bz)](P-thio-pCyEt) [2'-OMe-U-3'-CE-Phosphoramidite] is a modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of a 5'-O-DMTr-2'-fluoro-deoxyadenosine (2'-F-dA) with a benzoyl (Bz) protecting group, coupled with a 2'-O-Me-uridine. These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making it valuable for biochemical research and therapeutic applications.
CAT: BRP-01509
Molecular Formula: C60H67FN10O14P2S
Molecular Weight: 1265.26
Purity: ≥97% by HPLC
Appearance: White, off-white to faint yellow powder
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | -- | -- |
Storage: Store at -20 °C
InChIKey: JUARPBMSROJZJH-QYUWVQFQSA-N
IUPAC Name: (2R,3R,4R,5R)-2-((((((2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphorothioyl)oxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C60H67FN10O14P2S/c1-38(2)71(39(3)4)86(79-32-14-29-62)84-52-47(83-58(53(52)77-7)69-31-28-48(72)67-59(69)74)35-81-87(88,80-33-15-30-63)85-51-46(82-57(49(51)61)70-37-66-50-54(64-36-65-55(50)70)68-56(73)40-16-10-8-11-17-40)34-78-60(41-18-12-9-13-19-41,42-20-24-44(75-5)25-21-42)43-22-26-45(76-6)27-23-43/h8-13,16-28,31,36-39,46-47,49,51-53,57-58H,14-15,32-35H2,1-7H3,(H,67,72,74)(H,64,65,68,73)/t46-,47-,49-,51-,52-,53-,57-,58-,86?,87?/m1/s1
Synonyms: [5'-O-(4,4'-dimethoxytrityl)-2'-Fluoro-deoxyadenosine(benzoyl)](P-thio-pCyEt)[2'-O-methyl-U-3'-cyanoethyl-Phosphoramidite]; AfsUm; [5'-O-DMTr-2'-F A(Bz)](P-thio-pCyEt)[2'-OMe-U-3'-CE Phosphoramidite]
](pcyet)[2'-ome-u](pcyet)[2'-ome-a(bz)-3'-ce-phosphoramidite].gif)
[5'-O-DMTr-2'-OMe-G(iBu)](pCyEt)[2'-OMe-U](pCyEt)[2'-OMe-A(Bz)-3'-CE-Phosphoramidite]
Description: [5'-O-DMTr-2'-OMe-G(iBu)](pCyEt)[2'-OMe-U](pCyEt)[2'-OMe-A(Bz)-3'-CE-Phosphoramidite] is a complex modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of three sequentially linked nucleosides: a 5'-O-DMTr-2'-OMe-guanosine (G) with an isobutyryl (iBu) protecting group, a 2'-OMe-uridine (U), and a 2'-OMe-adenosine (A) with a benzoyl (Bz) protecting group. Each linkage is protected by a cyanoethyl (CE) group, ensuring stability during synthesis. These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making them valuable for advanced biochemical research and therapeutic applications.
CAT: BRP-01510
Molecular Formula: C79H93N16O24P3
Molecular Weight: 1743.62
Purity: ≥90% by HPLC
Appearance: White, off-white to faint yellow powder
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | -- | -- |
Storage: Store at -20 °C
InChIKey: PPJTYZPAIMAICU-AXFAHYDNSA-N
IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((((((2R,3R,4R,5R)-2-((((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C79H93N16O24P3/c1-47(2)71(97)90-77-89-70-61(73(99)91-77)86-46-94(70)76-67(107-11)63(56(114-76)41-108-79(51-23-16-13-17-24-51,52-25-29-54(103-7)30-26-52)53-27-31-55(104-8)32-28-53)118-122(102,111-40-20-36-82)113-43-58-64(66(106-10)74(116-58)92-37-33-59(96)87-78(92)100)119-121(101,110-39-19-35-81)112-42-57-62(117-120(109-38-18-34-80)95(48(3)4)49(5)6)65(105-9)75(115-57)93-45-85-60-68(83-44-84-69(60)93)88-72(98)50-21-14-12-15-22-50/h12-17,21-33,37,44-49,56-58,62-67,74-76H,18-20,38-43H2,1-11H3,(H,87,96,100)(H,83,84,88,98)(H2,89,90,91,97,99)/t56-,57-,58-,62-,63-,64-,65-,66-,67-,74-,75-,76-,120?,121?,122?/m1/s1
Synonyms: GmUmAm; [5'-O-DMTr-2'-OMe-G(iBu)](pCyEt)[2'-OMe_x005f_x0002_U](pCyEt)[2'-OMe-dA(Bz)-3'-CE-Phosphoramidite]
](pcyet)[2'-ome-u](pcyet)[2'-ome-a(bz)-3'-ce-phosphoramidite].gif)
[5'-O-DMTr-2'-OMe-A(Bz)](pCyEt)[2'-OMe-U](pCyEt)[2'-OMe-A(Bz)-3'-CE-Phosphoramidite]
Description: [5'-O-DMTr-2'-OMe-A(Bz)](pCyEt)[2'-OMe-U](pCyEt)[2'-OMe-A(Bz)-3'-CE-Phosphoramidite] is a complex modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of three sequentially linked nucleosides: a 5'-O-DMTr-2'-O-methyl-adenosine (2'-OMe-A) with a benzoyl (Bz) protecting group, a 2'-O-methyl-uridine (2'-OMe-U), and another 2'-O-methyl-adenosine (2'-OMe-A) with a benzoyl (Bz) protecting group. Each linkage is protected by a cyanoethyl (CE) group, ensuring stability during synthesis. These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making them valuable for advanced biochemical research and therapeutic applications.
CAT: BRP-01511
Molecular Formula: C82H91N16O23P3
Molecular Weight: 1761.64
Purity: ≥90% by HPLC
Appearance: White, off-white to faint yellow powder
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | -- | -- |
Storage: Store at -20 °C
InChIKey: QLLYUEFHCYOUCU-YNFWSCMJSA-N
IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((((((2R,3R,4R,5R)-2-((((((2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C82H91N16O23P3/c1-51(2)98(52(3)4)122(111-41-19-37-83)119-66-61(117-79(69(66)107-7)96-49-90-64-72(86-47-88-74(64)96)93-76(100)53-22-13-10-14-23-53)45-114-123(103,112-42-20-38-84)121-68-62(118-78(70(68)108-8)95-40-36-63(99)92-81(95)102)46-115-124(104,113-43-21-39-85)120-67-60(116-80(71(67)109-9)97-50-91-65-73(87-48-89-75(65)97)94-77(101)54-24-15-11-16-25-54)44-110-82(55-26-17-12-18-27-55,56-28-32-58(105-5)33-29-56)57-30-34-59(106-6)35-31-57/h10-18,22-36,40,47-52,60-62,66-71,78-80H,19-21,41-46H2,1-9H3,(H,92,99,102)(H,86,88,93,100)(H,87,89,94,101)/t60-,61-,62-,66-,67-,68-,69-,70-,71-,78-,79-,80-,122?,123?,124?/m1/s1
Synonyms: AmUmAm; [5'-O-DMTr-2'-OMe-dA(Bz)](pCyEt)[2'-OMe_x005f_x0002_U](pCyEt)[2'-OMe-dA(Bz)-3'-CE-Phosphoramidite]
](pcyet)[2'-f-dc(ac)](pcyet)[2'-f-da(bz)-3'-ce-phosphoramidite].gif)
[5'-O-DMTr-2'-F-dC(Ac)](pCyEt)[2'-F-dC(Ac)](pCyEt)[2'-F-dA(Bz)-3'-CE-Phosphoramidite]
Description: [5'-O-DMTr-2'-F-dC(Ac)](pCyEt)[2'-F-dC(Ac)](pCyEt)[2'-F-dA(Bz)-3'-CE-Phosphoramidite] is a complex modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of three sequentially linked nucleosides: a 5'-O-DMTr-2'-fluoro-deoxycytidine (2'-F-dC) with an acetyl (Ac) protecting group, a second 2'-fluoro-deoxycytidine (2'-F-dC) with an acetyl (Ac) protecting group, and a 2'-fluoro-deoxyadenosine (2'-F-dA) with a benzoyl (Bz) protecting group. Each linkage is protected by a cyanoethyl (CE) group, ensuring stability during synthesis. These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making them valuable for advanced biochemical research and therapeutic applications.
CAT: BRP-01512
Molecular Formula: C75H83F3N15O21P3
Molecular Weight: 1680.49
Purity: ≥90% by HPLC
Appearance: White, off-white to faint yellow powder
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | -- | -- |
Storage: Store at -20 °C
InChIKey: AQOHBSZMZWPISB-HLOZHUBLSA-N
IUPAC Name: (2R,3R,4R,5R)-2-((((((2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((((((2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-4-fluorotetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-5-(6-benzamido-9H-purin-9-yl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C75H83F3N15O21P3/c1-45(2)93(46(3)4)115(104-37-15-32-79)112-64-56(110-72(60(64)76)92-44-84-63-67(82-43-83-68(63)92)89-69(96)49-18-11-9-12-19-49)41-107-116(99,105-38-16-33-80)114-66-57(111-71(62(66)78)91-36-31-59(86-48(6)95)88-74(91)98)42-108-117(100,106-39-17-34-81)113-65-55(109-70(61(65)77)90-35-30-58(85-47(5)94)87-73(90)97)40-103-75(50-20-13-10-14-21-50,51-22-26-53(101-7)27-23-51)52-24-28-54(102-8)29-25-52/h9-14,18-31,35-36,43-46,55-57,60-62,64-66,70-72H,15-17,37-42H2,1-8H3,(H,82,83,89,96)(H,85,87,94,97)(H,86,88,95,98)/t55-,56-,57-,60-,61-,62-,64-,65-,66-,70-,71-,72-,115?,116?,117?/m1/s1
Synonyms: CfCfAf; [5'-O-DMTr-2'-F-C(Ac)](pCyEt)[2'-F_x005f_x0002_C(Ac)](pCyEt)[2'-F-dA(Bz)-3'-CE-Phosphoramidite]
](p-thio-pcyet)[2'-ome-a(bz)](p-thio-pcyet)[2'-ome-g(ibu)-3'-ce-phosphoramidite].gif)
[5'-O-DMTr-2'-OMe-C(Ac)](P-thio-pCyEt)[2'-OMe-A(Bz)](P-thio-pCyEt)[2'-OMe-G(iBu)-3'-CE-Phosphoramidite]
Description: [5'-O-DMTr-2'-OMe-C(Ac)](P-thio-pCyEt)[2'-OMe-A(Bz)](P-thio-pCyEt)[2'-OMe-G(iBu)-3'-CE-Phosphoramidite] is a complex modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of three sequentially linked nucleosides: a 5'-O-DMTr-2'-O-methyl-cytidine (2'-OMe-C) with an acetyl (Ac) protecting group, a 2'-O-methyl-adenosine (2'-OMe-A) with a benzoyl (Bz) protecting group, and a 2'-O-methyl-guanosine (2'-OMe-G) with an isobutyryl (iBu) protecting group. Each linkage is protected by a phosphorothioate (P-thio) group and a cyanoethyl (CE) group, ensuring stability during synthesis. These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making them valuable for advanced biochemical research and therapeutic applications.
CAT: BRP-01513
Molecular Formula: C81H96N17O22P3S2
Molecular Weight: 1816.80
Purity: ≥90% by HPLC
Appearance: White, off-white to faint yellow powder
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Storage: Store at -20 °C
InChIKey: KFIFRWCOOLGJGU-WPIHGYMGSA-N
IUPAC Name: (2R,3R,4R,5R)-2-((((((2R,3R,4R,5R)-2-((((((2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphorothioyl)oxy)methyl)-5-(6-benzamido-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphorothioyl)oxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C81H96N17O22P3S2/c1-48(2)73(100)93-79-92-72-63(75(102)94-79)88-47-97(72)77-67(106-10)64(118-121(110-39-19-35-82)98(49(3)4)50(5)6)59(116-77)43-113-122(124,111-40-20-36-83)120-66-60(117-78(69(66)108-12)96-46-87-62-70(85-45-86-71(62)96)91-74(101)52-22-15-13-16-23-52)44-114-123(125,112-41-21-37-84)119-65-58(115-76(68(65)107-11)95-38-34-61(89-51(7)99)90-80(95)103)42-109-81(53-24-17-14-18-25-53,54-26-30-56(104-8)31-27-54)55-28-32-57(105-9)33-29-55/h13-18,22-34,38,45-50,58-60,64-69,76-78H,19-21,39-44H2,1-12H3,(H,85,86,91,101)(H,89,90,99,103)(H2,92,93,94,100,102)/t58-,59-,60-,64-,65-,66-,67-,68-,69-,76-,77-,78-,121?,122?,123?/m1/s1
Synonyms: CmsAmsGm; [5'-O-DMTr-2'-OMe-C(Ac)](P-thio-pCyEt)[2'-OMe dA(Bz)](P-thio-pCyEt)[2'-OMe-G(iBu)-3'-CE_x005f_x0002_Phosphoramidite]
[2'-ome-a(bz)](pcyet)[2'-ome-a(bz)-3'-ce-phosphoramidite].gif)
[5'-O-DMTr-2'-OMe-U](pCyEt)[2'-OMe-A(Bz)](pCyEt)[2'-OMe-A(Bz)-3'-CE-Phosphoramidite]
Description: [5'-O-DMTr-2'-OMe-U](pCyEt)[2'-OMe-A(Bz)](pCyEt)[2'-OMe-A(Bz)-3'-CE-Phosphoramidite] is a complex modified nucleoside phosphoramidite used in oligonucleotide synthesis. It consists of three sequentially linked nucleosides: a 5'-O-DMTr-2'-O-methyl-uridine (2'-OMe-U), a 2'-O-methyl-adenosine (2'-OMe-A) with a benzoyl (Bz) protecting group, and another 2'-O-methyl-adenosine (2'-OMe-A) with a benzoyl (Bz) protecting group. Each linkage is protected by a cyanoethyl (CE) group, ensuring stability during synthesis. These modifications enhance the stability, binding specificity, and resistance to enzymatic degradation of the resulting oligonucleotides, making them valuable for advanced biochemical research and therapeutic applications.
CAT: BRP-01514
Molecular Formula: C82H91N16O23P3
Molecular Weight: 1761.64
Purity: ≥90% by HPLC
Appearance: White, off-white to faint yellow powder
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Storage: Store at -20 °C
InChIKey: HDBXZWVSPSMPEB-YNFWSCMJSA-N
IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((((((2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-4-methoxytetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphoryl)oxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C82H91N16O23P3/c1-51(2)98(52(3)4)122(111-41-19-37-83)119-66-61(117-79(69(66)107-7)96-49-90-64-72(86-47-88-74(64)96)93-76(100)53-22-13-10-14-23-53)45-114-123(103,112-42-20-38-84)121-68-62(118-80(71(68)109-9)97-50-91-65-73(87-48-89-75(65)97)94-77(101)54-24-15-11-16-25-54)46-115-124(104,113-43-21-39-85)120-67-60(116-78(70(67)108-8)95-40-36-63(99)92-81(95)102)44-110-82(55-26-17-12-18-27-55,56-28-32-58(105-5)33-29-56)57-30-34-59(106-6)35-31-57/h10-18,22-36,40,47-52,60-62,66-71,78-80H,19-21,41-46H2,1-9H3,(H,92,99,102)(H,86,88,93,100)(H,87,89,94,101)/t60-,61-,62-,66-,67-,68-,69-,70-,71-,78-,79-,80-,122?,123?,124?/m1/s1
Synonyms: UmAmAm; [5'-O-DMTr-2'-OMe-U](pCyEt)[2'-OMe-dA(Bz)](pCyEt)[2'-OMe-dA(Bz)-3'-CE_x005f_x0002_Phosphoramidite]
DMTr-O Diethyleneglycol Phosphoramidite
Description: DMTr-O Diethyleneglycol Phosphoramidite is a phosphoramidite reagent used in solid-phase oligonucleotide synthesis. This phosphoramidite facilitates the efficient and controlled synthesis of oligonucleotides with high purity. The bulky protecting groups on the backbone provide stability during synthesis and can be selectively removed during deprotection steps. This reagent is commonly used in automated oligonucleotide synthesis for various molecular biology and biotechnology applications.
CAT: BRP-01515
CAS: 362013-57-8
Molecular Formula: C34H45N2O6P
Molecular Weight: 608.72
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InChIKey: VTWDQGJYTBUVCR-UHFFFAOYSA-N
CanonicalSMILES: N#CCCOP(OCCOCCOC(C=1C=CC=CC1)(C2=CC=C(OC)C=C2)C3=CC=C(OC)C=C3)N(C(C)C)C(C)C
IUPAC Name: 2-(2-(bis(4-methoxyphenyl)(phenyl)methoxy)ethoxy)ethyl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C34H45N2O6P/c1-27(2)36(28(3)4)43(41-22-10-21-35)42-26-24-39-23-25-40-34(29-11-8-7-9-12-29,30-13-17-32(37-5)18-14-30)31-15-19-33(38-6)20-16-31/h7-9,11-20,27-28H,10,22-26H2,1-6H3
Synonyms: Phosphoramidous acid, bis(1-methylethyl)-, 2-[2-[bis(4-methoxyphenyl)phenylmethoxy]ethoxy]ethyl 2-cyanoethyl ester
5'-Cholesterol PEG5-CE Phosphoramidite
Description: 5'-Cholesterol PEG5-CE Phosphoramidite is a modified phosphoramidite used in oligonucleotide synthesis to introduce a cholesterol moiety and a PEG (polyethylene glycol) spacer at the 5' end of the oligonucleotide. This modification enhances the stability, solubility, and cellular uptake of the oligonucleotide, making it useful for various applications such as antisense therapy, siRNA, and molecular probes.
CAT: BRP-01516
Molecular Formula: C46H83N2O7P
Molecular Weight: 807.15
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InChIKey: ZYJFPTPFCJYMIF-GNUFTJHZSA-N
IUPAC Name: 2-cyanoethyl (14-(((3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)-3,6,9,12-tetraoxatetradecyl) diisopropylphosphoramidite
InChI: InChI=1S/C46H83N2O7P/c1-35(2)12-10-13-38(7)42-16-17-43-41-15-14-39-34-40(18-20-45(39,8)44(41)19-21-46(42,43)9)53-32-30-51-28-26-49-24-25-50-27-29-52-31-33-55-56(54-23-11-22-47)48(36(3)4)37(5)6/h14,35-38,40-44H,10-13,15-21,23-34H2,1-9H3/t38-,40+,41+,42-,43+,44+,45+,46-,56?/m1/s1
5'-Biotin Phosphoramidite
Description: 5'-Biotin Phosphoramidite is a modified phosphoramidite used in oligonucleotide synthesis to introduce a biotin molecule at the 5' end of the oligonucleotide. Introducing biotin at the 5' end allows for easy conjugation of the oligonucleotide to streptavidin or avidin, enabling applications like DNA/RNA labeling, pull-down assays, detection of nucleic acid hybridization, and immobilization of oligonucleotides onto solid supports.
CAT: BRP-01517
CAS: 1807503-79-2
Molecular Formula: C46H64N5O6PS
Molecular Weight: 846.08
Purity: ≥95%
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InChIKey: RBXYKQBFPLXSJS-UHFFFAOYSA-N
CanonicalSMILES: CC(C)N(C(C)C)P(OCCCCCCNC(=O)CCCCC1C2C(CS1)N(C(=O)N2)C(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OCCC#N
IUPAC Name: 5-[3-[bis(4-methoxyphenyl)-phenylmethyl]-2-oxo-3a,4,6,6a-tetrahydro-1H-thieno[3,4-d]imidazol-6-yl]-N-[6-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyhexyl]pentanamide
InChI: InChI=1S/C46H64N5O6PS/c1-34(2)51(35(3)4)58(57-32-16-29-47)56-31-15-8-7-14-30-48-43(52)20-13-12-19-42-44-41(33-59-42)50(45(53)49-44)46(36-17-10-9-11-18-36,37-21-25-39(54-5)26-22-37)38-23-27-40(55-6)28-24-38/h9-11,17-18,21-28,34-35,41-42,44H,7-8,12-16,19-20,30-33H2,1-6H3,(H,48,52)(H,49,53)
Synonyms: Phosphoramidous acid, N,N-bis(1-methylethyl)-, 6-[[5-[1-[bis(4-methoxyphenyl)phenylmethyl]hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]hexyl 2-cyanoethyl ester; 6-(5-(1-(Bis(4-methoxyphenyl)(phenyl)methyl)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)hexyl (2-cyanoethyl) diisopropylphosphoramidite
ICG-NHS
Description: ICG-NHS is synthesized by conjugating NHS to the carboxyl group of ICG, creating an activated ester. This NHS-activated ICG can then react specifically with primary amines on molecules like proteins, peptides, or oligonucleotides to form stable amide bonds. ICG-NHS conjugates are commonly used for labeling biomolecules for imaging, targeting, or drug delivery purposes in biological research and medical diagnostics.
CAT: BRP-01518
CAS: 1622335-40-3
Molecular Formula: C49H53N3O7S
Molecular Weight: 828.03
Purity: ≥95%
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InChIKey: KDJUNNVUQBKNAY-UHFFFAOYSA-N
CanonicalSMILES: CC1(C(=[N+](C2=C1C3=CC=CC=C3C=C2)CCCCCC(=O)ON4C(=O)CCC4=O)C=CC=CC=CC=C5C(C6=C(N5CCCCS(=O)(=O)[O-])C=CC7=CC=CC=C76)(C)C)C
IUPAC Name: 4-[2-[7-[3-[6-(2,5-dioxopyrrolidin-1-yl)oxy-6-oxohexyl]-1,1-dimethylbenzo[e]indol-3-ium-2-yl]hepta-2,4,6-trienylidene]-1,1-dimethylbenzo[e]indol-3-yl]butane-1-sulfonate
InChI: InChI=1S/C49H53N3O7S/c1-48(2)41(50(39-28-26-35-19-12-14-21-37(35)46(39)48)32-16-8-11-25-45(55)59-52-43(53)30-31-44(52)54)23-9-6-5-7-10-24-42-49(3,4)47-38-22-15-13-20-36(38)27-29-40(47)51(42)33-17-18-34-60(56,57)58/h5-7,9-10,12-15,19-24,26-29H,8,11,16-18,25,30-34H2,1-4H3
Synonyms: 1H-Benz[e]indolium, 2-[7-[1,3-dihydro-1,1-dimethyl-3-(4-sulfobutyl)-2H-benz[e]indol-2-ylidene]-1,3,5-heptatrien-1-yl]-3-[6-[(2,5-dioxo-1-pyrrolidinyl)oxy]-6-oxohexyl]-1,1-dimethyl-, inner salt; Indocyanine Green-NHS; 4-(2-(7-(3-(6-((2,5-dioxopyrrolidin-1-yl)oxy)-6-oxohexyl)-1,1-dimethyl-1H-benzo[e]indol-3-ium-2-yl)hepta-2,4,6-trien-1-ylidene)-1,1-dimethyl-1,2-dihydro-3H-benzo[e]indol-3-yl)butane-1-sulfonate; ICG-OSu; ICG NHS ester; ICG-NHS(mono-sulfo-cy7.5 NHS)
12-((2S,4R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxypyrrolidin-1-yl)-12-oxododecanoic acid
Description: 12-((2S,4R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxypyrrolidin-1-yl)-12-oxododecanoic acid is a chemically modified carbohydrate derivative. The peracetylation enhances its stability and lipophilicity, while the GalNAc moiety facilitates specific biological interactions, often used in targeted drug delivery systems. The L96-Acid acts as a linker to connect GalNAc to other functional groups or molecules, and the TEA salt ensures solubility and stability in solution. This compound is useful in pharmaceutical and biochemical applications, particularly in the development of targeted therapeutics and diagnostic agents.
CAT: BRP-01519
CAS: 1159408-70-4
Molecular Formula: C38H49NO7
Molecular Weight: 631.81
Purity: ≥95%
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Density: 1.154±0.06 g/cm3
Boiling Point: 779.4±60.0 °C at 760 mmHg
InChIKey: CEYLTMDXADTBEL-JHOUSYSJSA-N
CanonicalSMILES: COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)OCC4CC(CN4C(=O)CCCCCCCCCCC(=O)O)O
IUPAC Name: 12-[(2S,4R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxypyrrolidin-1-yl]-12-oxododecanoic acid
InChI: InChI=1S/C38H49NO7/c1-44-34-22-18-30(19-23-34)38(29-14-10-9-11-15-29,31-20-24-35(45-2)25-21-31)46-28-32-26-33(40)27-39(32)36(41)16-12-7-5-3-4-6-8-13-17-37(42)43/h9-11,14-15,18-25,32-33,40H,3-8,12-13,16-17,26-28H2,1-2H3,(H,42,43)/t32-,33+/m0/s1
Synonyms: 1-Pyrrolidinedodecanoic acid, 2-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-4-hydroxy-λ-oxo-, (2S,4R)-; (2S,4R)-2-[[Bis(4-methoxyphenyl)phenylmethoxy]methyl]-4-hydroxy-λ-oxo-1-pyrrolidinedodecanoic acid; Peracetylated GalNAc-L96-Acid-2
5'-DMT-PseudoUridine-CE-Phosphoramidite
Description: 5'-DMT-PseudoUridine-CE-Phosphoramidite is a phosphoramidite used in the chemical synthesis of oligonucleotides. This compound features a 5'-dimethoxytrityl (DMT) protecting group and a cyanoethyl (CE) phosphoramidite moiety, making it compatible with automated DNA/RNA synthesis protocols. Incorporating pseudouridine into synthetic RNA strands using this phosphoramidite is particularly valuable for research into RNA modifications, as pseudouridine can influence RNA stability, folding, and function. This tool aids in the development of RNA-based therapeutics and the study of RNA biology, enabling detailed exploration of pseudouridine's role in various cellular processes.
CAT: BRP-01520
CAS: 1244969-51-4
Molecular Formula: C39H47N4O9P
Molecular Weight: 746.79
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InChIKey: OMNBXPQZUMXZPM-LWYRIDHVSA-N
CanonicalSMILES: N#CCCOP(OC1C(O)C(OC1COC(C=2C=CC=CC2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)C5=CNC(=O)NC5=O)N(C(C)C)C(C)C
IUPAC Name: (2R,3S,4S,5S)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-4-hydroxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C39H47N4O9P/c1-25(2)43(26(3)4)53(50-22-10-21-40)52-36-33(51-35(34(36)44)32-23-41-38(46)42-37(32)45)24-49-39(27-11-8-7-9-12-27,28-13-17-30(47-5)18-14-28)29-15-19-31(48-6)20-16-29/h7-9,11-20,23,25-26,33-36,44H,10,22,24H2,1-6H3,(H2,41,42,45,46)/t33-,34+,35+,36-,53?/m1/s1
Synonyms: 2,4(1H,3H)-Pyrimidinedione, 5-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-β-D-ribofuranosyl]-; 5-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-β-D-ribofuranosyl]-2,4(1H,3H)-pyrimidinedione; 5'-DMT-PseudoUridine 3'-CE-Phosphoramidite
5'-ODMT cEt G Phosphoramidite (Amidite)
Description: 5'-ODMT cEt G Phosphoramidite is a specialized chemical reagent used in the synthesis of oligonucleotides. This compound features a guanosine (G) base modified with a 5'-O-(4,4'-dimethoxytrityl) (DMT) protecting group and a constrained ethyl (cEt) modification. The constrained ethyl (cEt) modification is designed to enhance the stability and binding affinity of the oligonucleotide, making it more resistant to nuclease degradation and improving its hybridization properties. This modification is particularly useful in the development of therapeutic oligonucleotides, such as antisense oligonucleotides, small interfering RNAs (siRNAs), and other nucleic acid-based drugs.
CAT: BRP-01526
CAS: 945628-66-0
Molecular Formula: C46H56N7O9P
Molecular Weight: 881.95
Purity: ≥98% by HPLC
Appearance: White to off-white solid
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Storage: Store at -20 °C, stored under nitrogen, away from moisture
InChIKey: VMDSRWMHPUGGSZ-KHGLYSIJSA-N
Solubility: Soluble in DMSO
CanonicalSMILES: CC1C2(C(C(O1)C(O2)N3C=NC4=C3N=C(NC4=O)NC(=O)C(C)C)OP(N(C(C)C)C(C)C)OCCC#N)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC
IUPAC Name: N-[9-[(1S,3R,4R,6S,7S)-1-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-7-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-6-methyl-2,5-dioxabicyclo[2.2.1]heptan-3-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide
InChI: InChI=1S/C46H56N7O9P/c1-28(2)41(54)50-44-49-40-37(42(55)51-44)48-27-52(40)43-38-39(62-63(59-25-13-24-47)53(29(3)4)30(5)6)45(61-43,31(7)60-38)26-58-46(32-14-11-10-12-15-32,33-16-20-35(56-8)21-17-33)34-18-22-36(57-9)23-19-34/h10-12,14-23,27-31,38-39,43H,13,25-26H2,1-9H3,(H2,49,50,51,54,55)/t31-,38+,39-,43+,45-,63?/m0/s1
Synonyms: N2-ibu-G-(S)-cEt-Phosphoramidite; 5'-ODMT cEt G Phosphoramidite; S-cEt-G phosphoramidite; (1S,3R,4R,6S,7S)-1-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-6-methyl-2,5-dioxabicyclo[2.2.1]heptan-7-yl (2-cyanoethyl) diisopropylphosphoramidite; N-[9-[2,5-Anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-6-deoxy-α-L-mannofuranosyl]-6,9-dihydro-6-oxo-1H-purin-2-yl]-2-methylpropanamide; S-cEt-G(iBu) phosphoramidite; CET-rG(ibu) Phosphoramidite; S-cEt-G(iBu)-CE-Phosphoramidite
5'-ODMT cEt m5U Phosphoramidite (Amidite)
Description: 5'-ODMT cEt m5U Phosphoramidite (Amidite) is a specialized chemical reagent used in the synthesis of oligonucleotides. This compound features a modified uridine (m5U) base, where the uridine is methylated at the 5-position, and includes a constrained ethyl (cEt) modification. Additionally, the 5' hydroxyl group is protected by a 4,4'-dimethoxytrityl (DMT) group. The constrained ethyl (cEt) modification enhances the stability and binding affinity of the oligonucleotide, making it more resistant to nuclease degradation and improving its hybridization properties. The methylation at the 5-position of uridine (m5U) is known to influence the binding affinity and specificity of the oligonucleotide to its target. This phosphoramidite is particularly useful in the development of therapeutic oligonucleotides, such as antisense oligonucleotides, small interfering RNAs (siRNAs), and other nucleic acid-based drugs, where enhanced stability and binding affinity are crucial for efficacy.
CAT: BRP-01527
CAS: 1197033-22-9
Molecular Formula: C42H51N4O9P
Molecular Weight: 786.86
Purity: ≥98% by HPLC
Appearance: White to off-white solid
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Storage: Store at -20 °C, stored under nitrogen, away from moisture
InChIKey: SEFBXGXPINACNI-IMMRMUFKSA-N
Solubility: Soluble in DMSO
CanonicalSMILES: CC1C2(C(C(O1)C(O2)N3C=C(C(=O)NC3=O)C)OP(N(C(C)C)C(C)C)OCCC#N)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC
IUPAC Name: 3-[[(1S,3R,4R,6S,7S)-1-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-6-methyl-3-(5-methyl-2,4-dioxopyrimidin-1-yl)-2,5-dioxabicyclo[2.2.1]heptan-7-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
InChI: InChI=1S/C42H51N4O9P/c1-27(2)46(28(3)4)56(52-24-12-23-43)55-37-36-39(45-25-29(5)38(47)44-40(45)48)54-41(37,30(6)53-36)26-51-42(31-13-10-9-11-14-31,32-15-19-34(49-7)20-16-32)33-17-21-35(50-8)22-18-33/h9-11,13-22,25,27-28,30,36-37,39H,12,24,26H2,1-8H3,(H,44,47,48)/t30-,36+,37-,39+,41-,56?/m0/s1
Synonyms: 1-[2,5-Anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-6-deoxy-α-L-mannofuranosyl]-5-methyl-2,4(1H,3H)-pyrimidinedione; 5'-ODMT cEt m5U Phosphoramidite; S-cEt-m5U phosphoramidite; CET-m5U Phosphoramidite; S-cEt-m5U-CE-Phosphoramidite; S-cEt-T phosphoramidite; CET-5-Me-U Phosphoramidite; S-cEt-T-CE-Phosphoramidite
5'-ODMT cEt N-Bz A Phosphoramidite (Amidite)
Description: 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) is a specialized reagent used in the chemical synthesis of oligonucleotides. This compound features an adenine (A) base with an N6-benzoyl (N-Bz) protection and a constrained ethyl (cEt) modification, along with a 5'-O-(4,4'-dimethoxytrityl) (DMT) protecting group. The constrained ethyl (cEt) modification enhances the stability and binding affinity of the oligonucleotide. This modification increases resistance to nuclease degradation and improves hybridization properties, making the resulting oligonucleotide more effective for various applications, including therapeutic uses. 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) is an important reagent for the synthesis of modified oligonucleotides, offering enhanced stability, binding affinity, and efficacy. It is particularly useful in the development of therapeutic oligonucleotides and other advanced nucleic acid-based research applications.
CAT: BRP-01528
CAS: 1197033-19-4
Molecular Formula: C49H54N7O8P
Molecular Weight: 899.97
Purity: ≥98% by HPLC
Appearance: White to off-white solid
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Storage: Store at -20 °C, stored under nitrogen, away from moisture
InChIKey: XHEVZGBLRSIPCO-DZGFXGBPSA-N
Solubility: Soluble in DMSO
CanonicalSMILES: CC1C2(C(C(O1)C(O2)N3C=NC4=C(N=CN=C43)NC(=O)C5=CC=CC=C5)OP(N(C(C)C)C(C)C)OCCC#N)COC(C6=CC=CC=C6)(C7=CC=C(C=C7)OC)C8=CC=C(C=C8)OC
IUPAC Name: N-[9-[(1S,3R,4R,6S,7S)-1-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-7-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-6-methyl-2,5-dioxabicyclo[2.2.1]heptan-3-yl]purin-6-yl]benzamide
InChI: InChI=1S/C49H54N7O8P/c1-32(2)56(33(3)4)65(61-28-14-27-50)64-43-42-47(55-31-53-41-44(51-30-52-45(41)55)54-46(57)35-15-10-8-11-16-35)63-48(43,34(5)62-42)29-60-49(36-17-12-9-13-18-36,37-19-23-39(58-6)24-20-37)38-21-25-40(59-7)26-22-38/h8-13,15-26,30-34,42-43,47H,14,28-29H2,1-7H3,(H,51,52,54,57)/t34-,42+,43-,47+,48-,65?/m0/s1
Synonyms: S-cEt-A phosphoramidite; 5'-ODMT cEt N-Bz A Phosphoramidite; 5'-ODMT cEt A(Bz) Phosphoramidite; N6-Bz-2'-O-4'-A-Locked-Ar-CET-Phosphoramidite; CET-A(Bz) Phosphoramidite; 5'-ODMT cEt N-Bz A Phosphoramidite Amidite; S-cEt-A(Bz)-CE-Phosphoramidite; N-[9-[2,5-Anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-6-deoxy-α-L-mannofuranosyl]-9H-purin-6-yl]benzamide
5'-ODMT cEt U Phosphoramidite (Amidite)
Description: 5'-ODMT cEt U Phosphoramidite (Amidite) is a specialized chemical reagent used in the synthesis of oligonucleotides. This compound features a uridine (U) base modified with a 5'-O-(4,4'-dimethoxytrityl) (DMT) protecting group and a constrained ethyl (cEt) modification. The constrained ethyl (cEt) modification is designed to enhance the stability and binding affinity of the oligonucleotide. This modification makes the oligonucleotide more resistant to nuclease degradation and improves its hybridization properties. The use of such modifications is particularly important in the development of therapeutic oligonucleotides, such as antisense oligonucleotides, small interfering RNAs (siRNAs), and other nucleic acid-based drugs, where stability and binding affinity are crucial for efficacy.
CAT: BRP-01529
CAS: 945628-51-3
Molecular Formula: C41H49N4O9P
Molecular Weight: 772.82
Purity: ≥98% by HPLC
Appearance: White to off-white solid
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Storage: Store at -20 °C, stored under nitrogen, away from moisture
InChIKey: MCMVDDGYNXOEJR-ZDHUYCFVSA-N
Solubility: Soluble in DMSO
CanonicalSMILES: CC1C2(C(C(O1)C(O2)N3C=CC(=O)NC3=O)OP(N(C(C)C)C(C)C)OCCC#N)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC
IUPAC Name: 3-[[(1S,3R,4R,6S,7S)-1-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-(2,4-dioxopyrimidin-1-yl)-6-methyl-2,5-dioxabicyclo[2.2.1]heptan-7-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
InChI: InChI=1S/C41H49N4O9P/c1-27(2)45(28(3)4)55(51-25-11-23-42)54-37-36-38(44-24-22-35(46)43-39(44)47)53-40(37,29(5)52-36)26-50-41(30-12-9-8-10-13-30,31-14-18-33(48-6)19-15-31)32-16-20-34(49-7)21-17-32/h8-10,12-22,24,27-29,36-38H,11,25-26H2,1-7H3,(H,43,46,47)/t29-,36+,37-,38+,40-,55?/m0/s1
Synonyms: U-(S)-cEt-Phosphoramidite; 1-[2,5-Anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-6-deoxy-α-L-mannofuranosyl]-2,4(1H,3H)-pyrimidinedione; 5'-ODMT cEt U Phosphoramidite; S-cEt-U phosphoramidite; CET-U Phosphoramidite; S-cEt-U-CE-Phosphoramidite; cEt U Amidite
