Phosphoramidites

2'-F G(iBu) OBn-amidite

Description: 2'-F G(iBu) OBn-amidite is a phosphoramidite reagent used in the synthesis of modified DNA oligonucleotides. It facilitates the controlled synthesis of DNA oligonucleotides with modified guanosine bases. These modifications enhance the stability, functionality, and specificity of the resulting oligonucleotide, making it valuable for various research and biomedical applications.

CAT: BRP-01584

Molecular Formula: C48H56FN6O8P

Molecular Weight: 894.98

Purity: >95%

Appearance: Off-white solid

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InChIKey: NMMXCYLXXJOCAP-AUNSQTKWSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: benzyl ((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl) diisopropylphosphoramidite

InChI: InChI=1S/C48H56FN6O8P/c1-30(2)44(56)52-47-51-43-41(45(57)53-47)50-29-54(43)46-40(49)42(63-64(55(31(3)4)32(5)6)61-27-33-15-11-9-12-16-33)39(62-46)28-60-48(34-17-13-10-14-18-34,35-19-23-37(58-7)24-20-35)36-21-25-38(59-8)26-22-36/h9-26,29-32,39-40,42,46H,27-28H2,1-8H3,(H2,51,52,53,56,57)/t39-,40-,42-,46-,64?/m1/s1

Synonyms: N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxyguanosine-3'-benzyloxy-phosphoramidite; 5'-O-DMTr-2'-F-dG(iBu)-3'-benzyloxy-phosphoramidite; 2'-F dG(iBu) OBn-amidite; 2'-F Guanosine (n-ibu) benzyloxy phosphoramidite

2'-F U OBn-amidite

Description: 2'-F U OBn-amidite is a phosphoramidite reagent used in the synthesis of modified DNA oligonucleotides. It allows for the controlled synthesis of DNA oligonucleotides with modified uridine bases. These modifications enhance the stability, functionality, and specificity of the resulting oligonucleotide, making it valuable for various research and biomedical applications.

CAT: BRP-01585

Molecular Formula: C43H49FN3O8P

Molecular Weight: 785.85

Purity: >95%

Appearance: Off-white solid

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InChIKey: LXSZAXFOUHFKJS-APEVFGHTSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: benzyl ((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluorotetrahydrofuran-3-yl) diisopropylphosphoramidite

InChI: InChI=1S/C43H49FN3O8P/c1-29(2)47(30(3)4)56(53-27-31-13-9-7-10-14-31)55-40-37(54-41(39(40)44)46-26-25-38(48)45-42(46)49)28-52-43(32-15-11-8-12-16-32,33-17-21-35(50-5)22-18-33)34-19-23-36(51-6)24-20-34/h7-26,29-30,37,39-41H,27-28H2,1-6H3,(H,45,48,49)/t37-,39-,40-,41-,56?/m1/s1

Synonyms: 5'-O-(4,4'-Dimethoxytrityl)-2'-fluoro-2'-deoxyuridine-3'-benzyloxy-phosphoramidite; 5'-O-DMTr-2'-F-dU-3'-benzyloxy-phosphoramidite; 2'-F-dU-3'-benzyloxy-phosphoramidite; 2'-F dU OBn-amidite

2'-F G(iBu) (TBSO)SATE-amidite

Description: 2'-F G(iBu) (TBSO)SATE-amidite is a phosphoramidite reagent used in the synthesis of modified DNA oligonucleotides. It facilitates the controlled synthesis of DNA oligonucleotides with modified guanosine bases. These modifications enhance the stability, functionality, and specificity of the resulting oligonucleotide, making it valuable for various research and biomedical applications.

CAT: BRP-01586

Molecular Formula: C54H76FN6O10PSSi

Molecular Weight: 1079.36

Purity: >95%

Appearance: Off-white solid

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InChIKey: AJSNCSZUDGUTOZ-WFDCMRDWSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: S-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethyl) 3-((tert-butyldimethylsilyl)oxy)-2,2-dimethylpropanethioate

InChI: InChI=1S/C54H76FN6O10PSSi/c1-34(2)47(62)58-51-57-46-44(48(63)59-51)56-33-60(46)49-43(55)45(71-72(61(35(3)4)36(5)6)68-29-30-73-50(64)53(10,11)32-69-74(14,15)52(7,8)9)42(70-49)31-67-54(37-19-17-16-18-20-37,38-21-25-40(65-12)26-22-38)39-23-27-41(66-13)28-24-39/h16-28,33-36,42-43,45,49H,29-32H2,1-15H3,(H2,57,58,59,62,63)/t42-,43-,45-,49-,72?/m1/s1

Synonyms: 2'-F dG(iBu) (TBSO)SATE-amidite; 2'-Fluoro-2'-deoxy Guanosine (N-iBu) 3'-O-(TBSO)SATE phosphoramidite

2'-F A(Bz) (TBSO)SATE-amidite

Description: 2'-F A(Bz) (TBSO)SATE-amidite is a phosphoramidite reagent used in the synthesis of modified DNA oligonucleotides. It enables the controlled synthesis of DNA oligonucleotides with modified adenine bases. These modifications enhance the stability, functionality, and specificity of the resulting oligonucleotide, making it valuable for various research and biomedical applications.

CAT: BRP-01587

Molecular Formula: C57H74FN6O9PSSi

Molecular Weight: 1097.38

Purity: >95%

Appearance: Off-white solid

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InChIKey: PBYQXESREXFRID-RONWHNMCSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: S-(2-(((((2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethyl) 3-((tert-butyldimethylsilyl)oxy)-2,2-dimethylpropanethioate

InChI: InChI=1S/C57H74FN6O9PSSi/c1-38(2)64(39(3)4)74(70-32-33-75-54(66)56(8,9)35-71-76(12,13)55(5,6)7)73-49-46(72-53(47(49)58)63-37-61-48-50(59-36-60-51(48)63)62-52(65)40-20-16-14-17-21-40)34-69-57(41-22-18-15-19-23-41,42-24-28-44(67-10)29-25-42)43-26-30-45(68-11)31-27-43/h14-31,36-39,46-47,49,53H,32-35H2,1-13H3,(H,59,60,62,65)/t46-,47-,49-,53-,74?/m1/s1

Synonyms: 2'-F dA(Bz) (TBSO)SATE-amidite; 2'-Fluoro-2'-deoxy Adenosine (N-Bz) 3'-O-(TBSO)SATE phosphoramidite

2'-F C(Bz) (TBSO)SATE-amidite

Description: 2'-F C(Bz) (TBSO)SATE-amidite is a phosphoramidite reagent used in the synthesis of modified DNA oligonucleotides. It allows for the controlled synthesis of DNA oligonucleotides with modified cytidine bases. These modifications enhance the stability, functionality, and specificity of the resulting oligonucleotide, making it useful for various research and biomedical applications.

CAT: BRP-01588

Molecular Formula: C56H74FN4O10PSSi

Molecular Weight: 1073.35

Purity: >95%

Appearance: Off-white solid

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InChIKey: HVBZXHBXPNTSPC-CEJOASKFSA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: S-(2-(((((2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethyl) 3-((tert-butyldimethylsilyl)oxy)-2,2-dimethylpropanethioate

InChI: InChI=1S/C56H74FN4O10PSSi/c1-38(2)61(39(3)4)72(68-34-35-73-52(63)55(8,9)37-69-74(12,13)54(5,6)7)71-49-46(70-51(48(49)57)60-33-32-47(59-53(60)64)58-50(62)40-20-16-14-17-21-40)36-67-56(41-22-18-15-19-23-41,42-24-28-44(65-10)29-25-42)43-26-30-45(66-11)31-27-43/h14-33,38-39,46,48-49,51H,34-37H2,1-13H3,(H,58,59,62,64)/t46-,48-,49-,51-,72?/m1/s1

Synonyms: 2'-F dC(Bz) (TBSO)SATE-amidite; 2'-Fluoro-2'-deoxy Cytidine (N-Bz) 3'-O-(TBSO)SATE phosphoramidite

2'-F U (TBSO)SATE-amidite

Description: 2'-F U (TBSO)SATE-amidite is a phosphoramidite reagent used in the synthesis of modified DNA oligonucleotides. It allows for the controlled synthesis of DNA oligonucleotides with modified uridine bases. These modifications enhance the stability, functionality, and specificity of the resulting oligonucleotide, making it valuable for various research and biomedical applications.

CAT: BRP-01589

Molecular Formula: C49H69FN3O10PSSi

Molecular Weight: 970.23

Purity: >95%

Appearance: Off-white solid

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InChIKey: JADSOFLFIWRFSE-JISWKONASA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: S-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluorotetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethyl) 3-((tert-butyldimethylsilyl)oxy)-2,2-dimethylpropanethioate

InChI: InChI=1S/C49H69FN3O10PSSi/c1-33(2)53(34(3)4)64(60-29-30-65-45(55)48(8,9)32-61-66(12,13)47(5,6)7)63-43-40(62-44(42(43)50)52-28-27-41(54)51-46(52)56)31-59-49(35-17-15-14-16-18-35,36-19-23-38(57-10)24-20-36)37-21-25-39(58-11)26-22-37/h14-28,33-34,40,42-44H,29-32H2,1-13H3,(H,51,54,56)/t40-,42-,43-,44-,64?/m1/s1

Synonyms: 2'-F dU (TBSO)SATE-amidite; 2'-Fluoro-2'-deoxy Uridine 3'-O-(TBSO)SATE phosphoramidite

2'-F U Obutyn-amidite

CAT: BRP-01590

CAS: 1840885-37-1

Molecular Formula: C40H47FN3O8P

Molecular Weight: 747.80

Purity: >95%

Appearance: Off-white solid

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InChIKey: MXTGLMKXIAYCPR-GFIGKZKCSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: O=C1C=CN(C(=O)N1)C2OC(COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)C(OP(OCCC#C)N(C(C)C)C(C)C)C2F

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluorotetrahydrofuran-3-yl but-3-yn-1-yl diisopropylphosphoramidite

InChI: InChI=1S/C40H47FN3O8P/c1-8-9-25-50-53(44(27(2)3)28(4)5)52-37-34(51-38(36(37)41)43-24-23-35(45)42-39(43)46)26-49-40(29-13-11-10-12-14-29,30-15-19-32(47-6)20-16-30)31-17-21-33(48-7)22-18-31/h1,10-24,27-28,34,36-38H,9,25-26H2,2-7H3,(H,42,45,46)/t34-,36-,37-,38-,53?/m1/s1

Synonyms: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-, 3'-[3-butyn-1-yl N,N-bis(1-methylethyl)phosphoramidite]; 2'-F dU Obutyn-amidite; 5'-O-(4,4'-Dimethoxytrityl)-2'-fluoro-2'-deoxyuridine-3'-Obutyn-phosphoramidite; 5'-O-DMTr-2'-F-dU-3'-Obutyn-phosphoramidite

2'-F C(Ac) Obutyn-amidite

Description: 2'-F C(Ac) Obutyn-amidite is a phosphoramidite reagent used in the synthesis of modified DNA oligonucleotides. It allows for the controlled synthesis of DNA oligonucleotides with modified cytidine bases. These modifications enhance the stability, functionality, and specificity of the resulting oligonucleotide, making it useful for various research and biomedical applications.

CAT: BRP-01591

CAS: 1840885-72-4

Molecular Formula: C42H50FN4O8P

Molecular Weight: 788.85

Purity: >95%

Appearance: Off-white solid

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InChIKey: PPGHLCKGBCZDSW-CYSIDSPMSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: O=C1N=C(C=CN1C2OC(COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)C(OP(OCCC#C)N(C(C)C)C(C)C)C2F)NC(=O)C

IUPAC Name: (2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl but-3-yn-1-yl diisopropylphosphoramidite

InChI: InChI=1S/C42H50FN4O8P/c1-9-10-26-53-56(47(28(2)3)29(4)5)55-39-36(54-40(38(39)43)46-25-24-37(44-30(6)48)45-41(46)49)27-52-42(31-14-12-11-13-15-31,32-16-20-34(50-7)21-17-32)33-18-22-35(51-8)23-19-33/h1,11-25,28-29,36,38-40H,10,26-27H2,2-8H3,(H,44,45,48,49)/t36-,38-,39-,40-,56?/m1/s1

Synonyms: Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-, 3'-[3-butyn-1-yl N,N-bis(1-methylethyl)phosphoramidite]; 2'-F dC(Ac) Obutyn-amidite; N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxycytidine-3'-Obutyn-phosphoramidite; 5'-O-DMTr-2'-F-dC(Ac)-3'-Obutyn-phosphoramidite

2'-Fluoro-2'-deoxy Cytidine (N-PAC) 3'-O-BMEG phosphoramidite

Description: 2'-Fluoro-2'-deoxy Cytidine (N-PAC) 3'-O-BMEG phosphoramidite is a phosphoramidite reagent crucial in the synthesis of modified nucleic acids. This compound is designed to introduce a modified cytidine nucleoside into oligonucleotide sequences with enhanced stability and functionality. It serves as an intermediate in automated DNA and RNA synthesis platforms, facilitating precise and reliable incorporation of modified nucleotides into sequence-defined oligonucleotides. This capability is instrumental in various biomedical research applications, including gene therapy, RNA interference (RNAi), and molecular diagnostics, where modified nucleic acids offer improved stability, specificity, and functionality.

CAT: BRP-01596

Molecular Formula: C52H64FN4O11PS

Molecular Weight: 1003.13

Purity: ≥95%

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InChIKey: ZACCDKZIIHZEBP-YDKKORBQSA-N

IUPAC Name: S-(2-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(2-oxo-4-(2-phenoxyacetamido)pyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethoxy)ethyl) 2-methylpropanethioate

InChI: InChI=1S/C52H64FN4O11PS/c1-35(2)50(59)70-32-31-63-29-30-66-69(57(36(3)4)37(5)6)68-48-44(67-49(47(48)53)56-28-27-45(55-51(56)60)54-46(58)34-64-43-17-13-10-14-18-43)33-65-52(38-15-11-9-12-16-38,39-19-23-41(61-7)24-20-39)40-21-25-42(62-8)26-22-40/h9-28,35-37,44,47-49H,29-34H2,1-8H3,(H,54,55,58,60)/t44-,47-,48-,49-,69?/m1/s1

Synonyms: 5'-O-DMTr-2'-F-dC(Pac)-3'-O-BMEG phosphoramidite

2'-Fluoro-2'-deoxy Guanosine (N-iPrPAC) 3'-O-BMEG phosphoramidite

Description: 2'-Fluoro-2'-deoxy Guanosine (N-iPrPAC) 3'-O-BMEG phosphoramidite is a phosphoramidite reagent used in the synthesis of modified nucleic acids. This compound is specifically designed to incorporate a modified guanosine nucleoside into oligonucleotide sequences, enhancing their stability and functionality. It serves as an intermediate in automated DNA and RNA synthesis platforms, facilitating precise and reliable incorporation of modified nucleotides into sequence-defined oligonucleotides. This capability is crucial in various biomedical research applications, including gene editing, RNA interference (RNAi), and molecular diagnostics, where modified nucleic acids provide improved stability, specificity, and functionality.

CAT: BRP-01597

Molecular Formula: C56H70FN6O11PS

Molecular Weight: 1085.24

Purity: ≥95%

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InChIKey: YCAKSFKUVSLOLZ-IUVNWIHYSA-N

IUPAC Name: S-(2-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(2-(2-(4-isopropylphenoxy)acetamido)-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethoxy)ethyl) 2-methylpropanethioate

InChI: InChI=1S/C56H70FN6O11PS/c1-35(2)39-16-22-45(23-17-39)70-33-47(64)59-55-60-51-49(52(65)61-55)58-34-62(51)53-48(57)50(74-75(63(37(5)6)38(7)8)72-29-28-69-30-31-76-54(66)36(3)4)46(73-53)32-71-56(40-14-12-11-13-15-40,41-18-24-43(67-9)25-19-41)42-20-26-44(68-10)27-21-42/h11-27,34-38,46,48,50,53H,28-33H2,1-10H3,(H2,59,60,61,64,65)/t46-,48-,50-,53-,75?/m1/s1

Synonyms: 5'-O-DMTr-2'-F-dG(iPr-Pac)-3'-O-BMEG phosphoramidite

2'-Fluoro-2'-deoxy Uridine 3'-O-BMEG phosphoramidite

Description: 2'-Fluoro-2'-deoxy Uridine 3'-O-BMEG phosphoramidite is a phosphoramidite reagent used in the synthesis of modified nucleic acids, specifically incorporating a modified uridine nucleoside into oligonucleotide sequences. It facilitates the synthesis of nucleic acids with enhanced stability and functionality. It serves as an intermediate in automated DNA and RNA synthesis, enabling precise incorporation of modified uridine nucleotides into sequence-defined oligonucleotides. This capability supports various biomedical research applications, including gene therapy, RNA interference (RNAi), and molecular diagnostics, where modified nucleic acids offer improved performance in terms of stability, specificity, and functionality.

CAT: BRP-01598

CAS: 1219597-57-5

Molecular Formula: C44H57FN3O10PS

Molecular Weight: 869.98

Purity: ≥95%

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InChIKey: MQTFINZTMLJCIH-KVTBCOQSSA-N

CanonicalSMILES: CC(C)C(=O)SCCOCCOP(N(C(C)C)C(C)C)OC1C(OC(C1F)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: S-[2-[2-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(2,4-dioxopyrimidin-1-yl)-4-fluorooxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxyethoxy]ethyl] 2-methylpropanethioate

InChI: InChI=1S/C44H57FN3O10PS/c1-29(2)42(50)60-27-26-54-24-25-56-59(48(30(3)4)31(5)6)58-40-37(57-41(39(40)45)47-23-22-38(49)46-43(47)51)28-55-44(32-12-10-9-11-13-32,33-14-18-35(52-7)19-15-33)34-16-20-36(53-8)21-17-34/h9-23,29-31,37,39-41H,24-28H2,1-8H3,(H,46,49,51)/t37-,39-,40-,41-,59?/m1/s1

Synonyms: 5'-O-DMTr-2'-F-dU-3'-O-BMEG phosphoramidite; S-(2-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluorotetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethoxy)ethyl) 2-methylpropanethioate; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-, 3'-[2-[2-[(2-methyl-1-oxopropyl)thio]ethoxy]ethyl N,N-bis(1-methylethyl)phosphoramidite]

2'-Fluoro-2'-deoxy Adenosine (N-PAC) 3'-O-BMEG phosphoramidite

Description: 2'-Fluoro-2'-deoxy Adenosine (N-PAC) 3'-O-BMEG phosphoramidite is a phosphoramidite reagent used in the synthesis of modified nucleic acids, specifically designed to incorporate a modified adenosine nucleoside into oligonucleotide sequences. It serves as an intermediate in automated DNA and RNA synthesis platforms. This reagent is essential in biomedical research applications such as gene editing, RNA interference (RNAi), and molecular diagnostics, where modified nucleic acids are utilized for improved stability, specificity, and functional properties.

CAT: BRP-01599

Molecular Formula: C53H64FN6O10PS

Molecular Weight: 1027.15

Purity: ≥95%

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InChIKey: ULXOJEKGELECAK-BIRYJSLWSA-N

IUPAC Name: S-(2-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(6-(2-phenoxyacetamido)-9H-purin-9-yl)tetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethoxy)ethyl) 2-methylpropanethioate

InChI: InChI=1S/C53H64FN6O10PS/c1-35(2)52(62)72-30-29-65-27-28-68-71(60(36(3)4)37(5)6)70-48-44(31-67-53(38-15-11-9-12-16-38,39-19-23-41(63-7)24-20-39)40-21-25-42(64-8)26-22-40)69-51(46(48)54)59-34-57-47-49(55-33-56-50(47)59)58-45(61)32-66-43-17-13-10-14-18-43/h9-26,33-37,44,46,48,51H,27-32H2,1-8H3,(H,55,56,58,61)/t44-,46-,48-,51-,71?/m1/s1

Synonyms: 5'-O-DMTr-2'-F-dA(Pac)-3'-O-BMEG phosphoramidite

5-O-DMTr-1-O-Ac-2-F-2-deoxyribofuranose-3-CE-Phosphoramidite

Description: 5-O-DMTr-1-O-Ac-2-F-2-deoxyribofuranose-3-CE-Phosphoramidite is a phosphoramidite reagent used in oligonucleotide synthesis. It features a deoxyribose sugar with specific modifications: the 5'-hydroxyl group is protected by a dimethoxytrityl (DMTr) group, the 1'-hydroxyl group is acetylated (Ac), and a fluorine atom is substituted at the 2' position. These modifications enhance the stability and functionality of the nucleic acids. The 3'-cyanoethyl (CE) phosphoramidite group is crucial for the automated synthesis process, enabling efficient and precise addition of this modified sugar to the growing oligonucleotide chain. This reagent is valuable in the synthesis of stable and functional nucleic acid sequences for various research and therapeutic applications.

CAT: BRP-01606

Molecular Formula: C37H46FN2O8P

Molecular Weight: 696.75

Purity: ≥95% by UPLC

Appearance: White or off-white to light yellow powder

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InChIKey: YXVIYDHRSOENQP-NDCODMSPSA-N

IUPAC Name: (3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-3-fluorotetrahydrofuran-2-yl acetate

InChI: InChI=1S/C37H46FN2O8P/c1-25(2)40(26(3)4)49(45-23-11-22-39)48-35-33(47-36(34(35)38)46-27(5)41)24-44-37(28-12-9-8-10-13-28,29-14-18-31(42-6)19-15-29)30-16-20-32(43-7)21-17-30/h8-10,12-21,25-26,33-36H,11,23-24H2,1-7H3/t33-,34-,35-,36?,49?/m1/s1

Synonyms: 5-O-(4,4'-Dimethoxytrityl)-1-O-acetyl-2-fluoro-2-deoxyribofuranose-3-cyanoethyl Phosphoramidite

5-DMTr-2-F-1,2-dideoxyribose-3-CE-Phosphoramidite

Description: 5-DMTr-2-F-1,2-dideoxyribose-3-CE-Phosphoramidite is a key reagent in the synthesis of modified oligonucleotides, featuring a dideoxyribose sugar with a 5'-dimethoxytrityl (DMTr) protective group and a fluorine atom at the 2' position. The dideoxyribose lacks hydroxyl groups at both the 1' and 2' positions, except for the 3'-hydroxyl, which is modified with a cyanoethyl (CE) phosphoramidite group. This design increases the stability of the oligonucleotide and prevents chain extension at the 2' position. This reagent is particularly useful for creating stable, modified oligonucleotides for use in various molecular biology and therapeutic applications.

CAT: BRP-01607

Molecular Formula: C35H44FN2O6P

Molecular Weight: 638.72

Purity: ≥98% by HPLC

Appearance: White or off-white to faint yellow solid

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InChIKey: CYNXGQPRPXHCQI-PRVDSXFMSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(COC1COC(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)C4=CC=C(C=C4)OC)F

IUPAC Name: 3-[[(2R,3R,4S)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-fluorooxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C35H44FN2O6P/c1-25(2)38(26(3)4)45(43-22-10-21-37)44-34-32(36)23-41-33(34)24-42-35(27-11-8-7-9-12-27,28-13-17-30(39-5)18-14-28)29-15-19-31(40-6)20-16-29/h7-9,11-20,25-26,32-34H,10,22-24H2,1-6H3/t32-,33+,34-,45?/m0/s1

Synonyms: 5-O-(4,4'-Dimethoxytrityl)-2-fluoro-1-deoxyribose-3-cyanoethyl Phosphoramidite; (2R,3R,4S)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

3'-F-3'-dA(Bz)-2'-phosphoramidite

Description: 3'-F-3'-dA(Bz)-2'-phosphoramidite, an indispensable compound widely employed in the biomedical sector for the synthesis of oligonucleotides and nucleic acid analogs, holds paramount importance. Its modified structure renders it adept at enhancing stability, selectivity, and binding properties.

CAT: BRP-01609

CAS: 2127174-09-6

Molecular Formula: C47H51FN7O7P

Molecular Weight: 875.92

Purity: ≥95%

Appearance: Off-white solid

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InChIKey: WTXSTLCSPVTJTM-MSIRFHFKSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(C(OC1N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC)F

IUPAC Name: (2R,3S,4R,5R)-2-(6-benzamido-9H-purin-9-yl)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C47H51FN7O7P/c1-31(2)55(32(3)4)63(60-27-13-26-49)62-42-40(48)39(61-46(42)54-30-52-41-43(50-29-51-44(41)54)53-45(56)33-14-9-7-10-15-33)28-59-47(34-16-11-8-12-17-34,35-18-22-37(57-5)23-19-35)36-20-24-38(58-6)25-21-36/h7-12,14-25,29-32,39-40,42,46H,13,27-28H2,1-6H3,(H,50,51,53,56)/t39-,40-,42-,46-,63?/m1/s1

Synonyms: N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-3'-deoxy-3'-fluoroadenosine-2'-CED-phosphoramidite; N-[9-[(2R,3S,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-4-fluorooxolan-2-yl]purin-6-yl]benzamide; N-Benzoyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-2'-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-3'-deoxy-3'-fluoroadenosine; 5'-DMT-3'-fluoro-DA(BZ) amidite; 3'-F A(Bz) 2'-amidite

5'-Cholesterol-CE Phosphoramidite (BRP-01617)

Description: 5'-Cholesterol-CE Phosphoramidite is a powerful substance made entirely from plant-derived cholesterol that has the ability to fight hypercholesterolemia and various lipid disorders. Using innovative technology, it inhibits cholesterol synthesis in the liver, thereby reducing overall blood cholesterol levels. Due to its remarkable effectiveness, it is highly valued in the biopharmaceutical industry and widely used in the treatment of cardiovascular diseases.

CAT: BRP-01617

CAS: 143723-64-2

Molecular Formula: C43H76N3O4P

Molecular Weight: 730.07

Purity: >95%

Appearance: Light-yellow oily matter

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Boiling Point: 722.5±60.0 °C at 760 mmHg

InChIKey: LLDRAIRYAJXEEP-CRQKJHHESA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)OC(=O)NCCCCCCOP(N(C(C)C)C(C)C)OCCC#N)C)C

IUPAC Name: [(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] N-[6-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyhexyl]carbamate

InChI: InChI=1S/C43H76N3O4P/c1-31(2)16-14-17-34(7)38-20-21-39-37-19-18-35-30-36(22-24-42(35,8)40(37)23-25-43(38,39)9)50-41(47)45-27-12-10-11-13-28-48-51(49-29-15-26-44)46(32(3)4)33(5)6/h18,31-34,36-40H,10-17,19-25,27-30H2,1-9H3,(H,45,47)/t34-,36+,37+,38-,39+,40+,42+,43-,51?/m1/s1

Synonyms: Cholesteryl-3-carboxamidohexyl-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; Cholest-5-en-3-ol (3β)-, 3-[[6-[[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]oxy]hexyl]carbamate]; Cholest-5-en-3-ol (3β)-, [6-[[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]oxy]hexyl]carbamate; Cholest-5-en-3-ol, 3-(6-(((2-cyanoethoxy)(diisopropylamino)phosphino)oxy)hexyl)carbemate; Cholesterol C6 amine amidite; Cholesteryl-3-carboxamidohexyl-[2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite

U-(S)-GNA phosphoramidite

Description: U-(S)-GNA phosphoramidite, a chemical reagent frequently employed in the synthesis of modified oligonucleotides, has demonstrated its utility in the development of RNA therapeutics for diseases spanning cancer to viral infections. The structural distinctiveness of this reagent affords the resulting oligonucleotides improved stability and efficacy.

CAT: BRP-01619

CAS: 494784-15-5

Molecular Formula: C37H45N4O7P

Molecular Weight: 688.75

Purity: ≥98%

Appearance: Light yellow solid

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InChIKey: KZZGGKJIAMPACS-AQXIKWHWSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC(CN1C=CC(=O)NC1=O)COC(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)C4=CC=C(C=C4)OC

IUPAC Name: 3-[[(2S)-1-[bis(4-methoxyphenyl)-phenylmethoxy]-3-(2,4-dioxopyrimidin-1-yl)propan-2-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C37H45N4O7P/c1-27(2)41(28(3)4)49(47-24-10-22-38)48-34(25-40-23-21-35(42)39-36(40)43)26-46-37(29-11-8-7-9-12-29,30-13-17-32(44-5)18-14-30)31-15-19-33(45-6)20-16-31/h7-9,11-21,23,27-28,34H,10,24-26H2,1-6H3,(H,39,42,43)/t34-,49?/m0/s1

Synonyms: GNA U amidite; Phosphoramidous acid, bis(1-methylethyl)-, (1S)-2-[bis(4-methoxyphenyl)phenylmethoxy]-1-[(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)methyl]ethyl 2-cyanoethyl ester; (S)-GNA-U-phosphoramidite; DMT-U-(S)-GNA Phosphoramidite; (S)-1-(bis(4-methoxyphenyl)(phenyl)methoxy)-3-(2,4-dioxo-3, 4-dihydropyrimidin-1(2H)-yl)propan-2-yl(2-cyanoethyl)diisopropylphosphoramidite

N6-Benzoyl-5'-O-DMT-3'-O-methyladenosine 3'-CE-phosphoramidite

Description: N6-Benzoyl-5'-O-DMT-3'-O-methyladenosine 3'-CE-phosphoramidite is a highly specialized chemical compound utilized in the synthesis of novel RNA molecules. Its unparalleled structural complexity enables precise targeting of malignant cells, paving the way for enhanced efficacy in RNA-based therapeutics that aim to alleviate various ailments, such as cancer and viral infections. Such unprecedented capability in modulating gene expression makes N6-Benzoyl-5'-O-DMT-3'-O-methyladenosine 3'-CE-phosphoramidite an invaluable tool in cutting-edge genetic research.

CAT: BRP-01620

CAS: 179479-02-8

Molecular Formula: C48H54N7O8P

Molecular Weight: 887.97

Purity: >95%

Appearance: Off-white solid

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InChIKey: FVQVZAFXDJSVIC-PSVHYZMASA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(C(OC1N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC)OC

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-4-methoxyoxolan-2-yl]purin-6-yl]benzamide

InChI: InChI=1S/C48H54N7O8P/c1-32(2)55(33(3)4)64(61-28-14-27-49)63-43-42(59-7)40(62-47(43)54-31-52-41-44(50-30-51-45(41)54)53-46(56)34-15-10-8-11-16-34)29-60-48(35-17-12-9-13-18-35,36-19-23-38(57-5)24-20-36)37-21-25-39(58-6)26-22-37/h8-13,15-26,30-33,40,42-43,47H,14,28-29H2,1-7H3,(H,50,51,53,56)/t40-,42-,43-,47-,64?/m1/s1

Synonyms: N6-BZ-5'-O-DMTr-3'-O-methyladenosine-2'-O-CED-phosphoramidite; 3'-OMe A(Bz) 2'-amidite; N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-3'-O-methyladenosine-2'-cyanoethyl phosphoramidite; Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-methyl-, 2'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; 3'-O-Me-A(Bz)-2'-phosphoramidite; 3'-OMe-A(Bz) Phosphoramidite; 3'-O-Methyl Adenosine (n-bz) CED phosphoramidite

RSPACER CEP

Description: RSPACER CEP is a biomedical product designed to study Chronic Exertional Compartment Syndrome.

CAT: BRP-01621

CAS: 159299-31-7

Molecular Formula: C41H59N2O7PSi

Molecular Weight: 750.99

Purity: >95%

Appearance: Off-white solid

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InChIKey: URLPBMMJULLWTE-ZEGDCKMFSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(COC1COC(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)C4=CC=C(C=C4)OC)O[Si](C)(C)C(C)(C)C

IUPAC Name: 3-[[(2R,3R,4S)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxyoxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C41H59N2O7PSi/c1-30(2)43(31(3)4)51(48-27-15-26-42)49-39-37(46-28-38(39)50-52(10,11)40(5,6)7)29-47-41(32-16-13-12-14-17-32,33-18-22-35(44-8)23-19-33)34-20-24-36(45-9)25-21-34/h12-14,16-25,30-31,37-39H,15,27-29H2,1-11H3/t37-,38+,39-,51?/m1/s1

Synonyms: 5'-O-Dimethoxytrityl-1'-Deoxyribose-2'-O-TBDMS-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; rSpacer TBDMS CE Phosphoramidite; 2'-OTBS abasic amidite; D-Ribitol, 1,4-anhydro-5-O-[bis(4-methoxyphenyl)phenylmethyl]-2-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; D-Ribitol, 1,4-anhydro-5-O-[bis(4-methoxyphenyl)phenylmethyl]-2-O-[(1,1-dimethylethyl)dimethylsilyl]-, 2-cyanoethyl bis(1-methylethyl)phosphoramidite

2-Isobutyrylamino-9-(2'-O-tert-butyldimethylsilyl-5'-O-DMT-b-D-ribofuranosyl)purine 3'-CE phosphoramidite

Description: 2-Isobutyrylamino-9-(2'-O-tert-butyldimethylsilyl-5'-O-DMT-b-D-ribofuranosyl)purine 3'-CE phosphoramidite is an essential component in oligonucleotide synthesis for the biomedical industry. It is used in the modification and synthesis of nucleotide sequences targeting specific genes or diseases. Its unique properties allow for efficient and accurate incorporation into DNA and RNA strands, enabling researchers to study and develop therapeutic interventions for various conditions.

CAT: BRP-01622

CAS: 179558-91-9

Molecular Formula: C50H68N7O8PSi

Molecular Weight: 954.20

Purity: >95%

Appearance: Off-white solid

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InChIKey: XJRKARXGQAQMRG-KAZSGHHBSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CCCC(=O)NC1=NC=C2C(=N1)N(C=N2)C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N(C(C)C)C(C)C)OCCC#N)O[Si](C)(C)C(C)(C)C

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]purin-2-yl]butanamide

InChI: InChI=1S/C50H68N7O8PSi/c1-13-18-43(58)54-48-52-31-41-46(55-48)56(33-53-41)47-45(65-67(11,12)49(6,7)8)44(64-66(62-30-17-29-51)57(34(2)3)35(4)5)42(63-47)32-61-50(36-19-15-14-16-20-36,37-21-25-39(59-9)26-22-37)38-23-27-40(60-10)28-24-38/h14-16,19-28,31,33-35,42,44-45,47H,13,17-18,30,32H2,1-12H3,(H,52,54,55,58)/t42-,44-,45-,47-,66?/m1/s1

Synonyms: 2'-OTBS 2-amino(iBu)purine amidite; N-[9-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-O-[(1,1-dimethylethyl)dimethylsilyl]-β-D-ribofuranosyl]-9H-purin-2-yl]butanamide

2'-F G(iBu) OBn-amidite

2'-F U OBn-amidite

2'-F G(iBu) (TBSO)SATE-amidite

2'-F A(Bz) (TBSO)SATE-amidite

2'-F C(Bz) (TBSO)SATE-amidite

2'-F U (TBSO)SATE-amidite

2'-F U Obutyn-amidite

2'-F C(Ac) Obutyn-amidite

2'-Fluoro-2'-deoxy Cytidine (N-PAC) 3'-O-BMEG phosphoramidite

2'-Fluoro-2'-deoxy Guanosine (N-iPrPAC) 3'-O-BMEG phosphoramidite

2'-Fluoro-2'-deoxy Uridine 3'-O-BMEG phosphoramidite

2'-Fluoro-2'-deoxy Adenosine (N-PAC) 3'-O-BMEG phosphoramidite

5-O-DMTr-1-O-Ac-2-F-2-deoxyribofuranose-3-CE-Phosphoramidite

5-DMTr-2-F-1,2-dideoxyribose-3-CE-Phosphoramidite

3'-F-3'-dA(Bz)-2'-phosphoramidite

5'-Cholesterol-CE Phosphoramidite (BRP-01617)

U-(S)-GNA phosphoramidite

N6-Benzoyl-5'-O-DMT-3'-O-methyladenosine 3'-CE-phosphoramidite

RSPACER CEP

2-Isobutyrylamino-9-(2'-O-tert-butyldimethylsilyl-5'-O-DMT-b-D-ribofuranosyl)purine 3'-CE phosphoramidite

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