Phosphoramidites

MMT-2'-O-Methyl Guanosine (n-ibu) CED phosphoramidite

Description: MMT-2'-O-Methyl Guanosine (n-ibu) CED phosphoramidite is a specialized reagent employed in oligonucleotide synthesis. It features a guanosine nucleoside with a 2'-O-Methyl modification, protected by an isobutyryl (n-ibu) group, and coupled with a CED (2-cyanoethyl diisopropylphosphoramidite) moiety. The MMT (Monomethoxytrityl) group temporarily shields hydroxyl groups in nucleosides during synthesis. This phosphoramidite enables precise incorporation of the modified guanosine into nucleotide chains during solid-phase synthesis, vital for tailored oligonucleotide design in molecular biology, diagnostics, and therapeutics.

CAT: BRP-01271

CAS: 110782-32-6

Molecular Formula: C44H54N7O8P

Molecular Weight: 839.92

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InChIKey: FJAOBUANVXIWLD-FRQJXJFPSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C(=O)N=C(NC(=O)C(C)C)NC32)C1OC)COC(C=4C=CC=CC4)(C=5C=CC=CC5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C

IUPAC Name: 2-cyanoethyl ((2R,3R,4R,5R)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-methoxy-2-(((4-methoxyphenyl)diphenylmethoxy)methyl)tetrahydrofuran-3-yl) diisopropylphosphoramidite

InChI: InChI=1S/C44H54N7O8P/c1-28(2)40(52)48-43-47-39-36(41(53)49-43)46-27-50(39)42-38(55-8)37(59-60(57-25-15-24-45)51(29(3)4)30(5)6)35(58-42)26-56-44(31-16-11-9-12-17-31,32-18-13-10-14-19-32)33-20-22-34(54-7)23-21-33/h9-14,16-23,27-30,35,37-38,42H,15,25-26H2,1-8H3,(H2,47,48,49,52,53)/t35-,37-,38-,42-,60?/m1/s1

Synonyms: Guanosine, 5'-O-[(4-methoxyphenyl)diphenylmethyl]-2'-O-methyl-N-(2-methyl-1-oxopropyl)-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; 5'-O-MMTr-2'-O-Methyl-G(iBu)-3'-CE-Phosphoramidite

2'-O-Methyl Cytidine (N-PAC) 3'-O-BMEG phosphoramidite

Description: 2'-O-Methyl Cytidine (N-PAC) 3'-O-BMEG phosphoramidite is utilized in oligonucleotide synthesis. It involves a cytidine nucleoside that has been modified with a 2'-O-Methyl group, protected with a PAC group (phenoxyacetyl), and coupled with a 3'-O-BMEG (3'-O-benzyl-2'-O-methyl-2'-O-(2-cyanoethyl) guanosine) phosphoramidite. It facilitates the precise incorporation of modified cytidine into nucleotide chains during solid-phase synthesis, critical for various applications in molecular biology, genetics, diagnostics, and therapeutics.

CAT: BRP-01274

Molecular Formula: C53H67N4O12PS

Molecular Weight: 1015.16

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InChIKey: BDDJICCPICJTLQ-KLVGKUQJSA-N

IUPAC Name: S-(2-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxy-5-(2-oxo-4-(2-phenoxyacetamido)pyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethoxy)ethyl) 2-methylpropanethioate

InChI: InChI=1S/C53H67N4O12PS/c1-36(2)51(59)71-33-32-64-30-31-67-70(57(37(3)4)38(5)6)69-48-45(68-50(49(48)63-9)56-29-28-46(55-52(56)60)54-47(58)35-65-44-18-14-11-15-19-44)34-66-53(39-16-12-10-13-17-39,40-20-24-42(61-7)25-21-40)41-22-26-43(62-8)27-23-41/h10-29,36-38,45,48-50H,30-35H2,1-9H3,(H,54,55,58,60)/t45-,48-,49-,50-,70?/m1/s1

Synonyms: 5'-O-DMTr-2'-O-Methyl-C(Pac)-3'-O-BMEG phosphoramidite

2'-O-Methyl Guanosine (N-iPrPAC) 3'-O-BMEG phosphoramidite

Description: 2'-O-Methyl Guanosine (N-iPrPAC) 3'-O-BMEG phosphoramidite is used in oligonucleotide synthesis. It consists of a guanosine nucleoside modified with a 2'-O-Methyl group, protected with an isopropylphenoxyacetyl (iPr-Pac) group, and coupled with a 3'-O-BMEG phosphoramidite. It enables controlled and efficient incorporation of modified guanosine into oligonucleotide sequences, crucial for tailored oligonucleotide design in various biological applications.

CAT: BRP-01275

Molecular Formula: C57H73N6O12PS

Molecular Weight: 1097.26

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InChIKey: CXMDDZTWWYKURH-PZUNXSRFSA-N

IUPAC Name: S-(2-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-(2-(4-isopropylphenoxy)acetamido)-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethoxy)ethyl) 2-methylpropanethioate

InChI: InChI=1S/C57H73N6O12PS/c1-36(2)40-17-23-46(24-18-40)71-34-48(64)59-56-60-52-49(53(65)61-56)58-35-62(52)54-51(69-11)50(75-76(63(38(5)6)39(7)8)73-30-29-70-31-32-77-55(66)37(3)4)47(74-54)33-72-57(41-15-13-12-14-16-41,42-19-25-44(67-9)26-20-42)43-21-27-45(68-10)28-22-43/h12-28,35-39,47,50-51,54H,29-34H2,1-11H3,(H2,59,60,61,64,65)/t47-,50-,51-,54-,76?/m1/s1

Synonyms: 5'-O-DMTr-2'-O-Methyl-G(iPr-Pac)-3'-O-BMEG phosphoramidite

2'-O-Methyl Uridine 3'-O-BMEG phosphoramidite

Description: 2'-O-Methyl Uridine 3'-O-BMEG phosphoramidite is employed in oligonucleotide synthesis. It features a uridine nucleoside modified with a 2'-O-Methyl group and coupled with a 3'-O-BMEG phosphoramidite. It enables the precise incorporation of modified uridine into nucleotide chains during solid-phase synthesis, facilitating the design and synthesis of specialized oligonucleotides for use in molecular biology, genetics, diagnostics, and therapeutics.

CAT: BRP-01276

CAS: 1219597-71-3

Molecular Formula: C45H60N3O11PS

Molecular Weight: 882.01

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InChIKey: REAOWVIOVQIPDP-FSEQMNGPSA-N

CanonicalSMILES: CC(C)C(=O)SCCOCCOP(N(C(C)C)C(C)C)OC1C(OC(C1OC)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: S-[2-[2-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(2,4-dioxopyrimidin-1-yl)-4-methoxyoxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxyethoxy]ethyl] 2-methylpropanethioate

InChI: InChI=1S/C45H60N3O11PS/c1-30(2)43(50)61-28-27-55-25-26-57-60(48(31(3)4)32(5)6)59-40-38(58-42(41(40)54-9)47-24-23-39(49)46-44(47)51)29-56-45(33-13-11-10-12-14-33,34-15-19-36(52-7)20-16-34)35-17-21-37(53-8)22-18-35/h10-24,30-32,38,40-42H,25-29H2,1-9H3,(H,46,49,51)/t38-,40-,41-,42-,60?/m1/s1

Synonyms: S-(2-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethoxy)ethyl) 2-methylpropanethioate; 5'-O-DMTr-2'-O-Methyl-U-3'-O-BMEG phosphoramidite

2'-O-Methyl Adenosine (N-PAC) 3'-O-BMEG phosphoramidite

Description: 2'-O-Methyl Adenosine (N-PAC) 3'-O-BMEG phosphoramidite is utilized in oligonucleotide synthesis. It comprises an adenosine nucleoside modified with a 2'-O-Methyl group and protected with a PAC group (phenoxyacetyl), coupled with a 3'-O-BMEG (3'-O-benzyl-2'-O-methyl-2'-O-(2-cyanoethyl) guanosine) phosphoramidite. It facilitates precise incorporation of modified adenosine into nucleotide chains during solid-phase synthesis, critical for various applications in molecular biology, genetics, diagnostics, and therapeutics.

CAT: BRP-01277

CAS: 1219597-69-9

Molecular Formula: C54H67N6O11PS

Molecular Weight: 1039.18

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InChIKey: DZVZJNHAUNNRRG-JHMFWHMXSA-N

CanonicalSMILES: CC(C)C(=O)SCCOCCOP(N(C(C)C)C(C)C)OC1C(OC(C1OC)N2C=NC3=C(N=CN=C32)NC(=O)COC4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC

IUPAC Name: S-[2-[2-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-methoxy-5-[6-[(2-phenoxyacetyl)amino]purin-9-yl]oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxyethoxy]ethyl] 2-methylpropanethioate

InChI: InChI=1S/C54H67N6O11PS/c1-36(2)53(62)73-31-30-66-28-29-69-72(60(37(3)4)38(5)6)71-48-45(32-68-54(39-16-12-10-13-17-39,40-20-24-42(63-7)25-21-40)41-22-26-43(64-8)27-23-41)70-52(49(48)65-9)59-35-57-47-50(55-34-56-51(47)59)58-46(61)33-67-44-18-14-11-15-19-44/h10-27,34-38,45,48-49,52H,28-33H2,1-9H3,(H,55,56,58,61)/t45-,48-,49-,52-,72?/m1/s1

Synonyms: 5'-O-DMTr-2'-O-Methyl-A(Pac)-3'-O-BMEG phosphoramidite; S-(2-(2-(((((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxy-5-(6-(2-phenoxyacetamido)-9H-purin-9-yl)tetrahydrofuran-3-yl)oxy)(diisopropylamino)phosphaneyl)oxy)ethoxy)ethyl) 2-methylpropanethioate; Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-N-(2-phenoxyacetyl)-, 3'-[2-[2-[(2-methyl-1-oxopropyl)thio]ethoxy]ethyl N,N-bis(1-methylethyl)phosphoramidite]

2'-O-Methyl Adenosine (n-bz) ethyl phosphoramidite

Description: 2'-O-Methyl Adenosine (n-bz) ethyl phosphoramidite is used in oligonucleotide synthesis. It involves an adenosine nucleoside modified with a 2'-O-Methyl group and protected with a benzoyl (n-bz) group, coupled with an ethyl phosphoramidite. It enables controlled and efficient incorporation of modified adenosine into oligonucleotide sequences, crucial for tailored oligonucleotide design in various biological applications.

CAT: BRP-01278

CAS: 179478-97-8

Molecular Formula: C47H55N6O8P

Molecular Weight: 862.95

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InChIKey: UGNHWRCMCLTGDV-JIUDHRTHSA-N

CanonicalSMILES: O=C(NC1=NC=NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP(OCC)N(C(C)C)C(C)C)C3OC)C=7C=CC=CC7

IUPAC Name: (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl ethyl diisopropylphosphoramidite

InChI: InChI=1S/C47H55N6O8P/c1-9-59-62(53(31(2)3)32(4)5)61-41-39(60-46(42(41)57-8)52-30-50-40-43(48-29-49-44(40)52)51-45(54)33-16-12-10-13-17-33)28-58-47(34-18-14-11-15-19-34,35-20-24-37(55-6)25-21-35)36-22-26-38(56-7)27-23-36/h10-27,29-32,39,41-42,46H,9,28H2,1-8H3,(H,48,49,51,54)/t39-,41-,42-,46-,62?/m1/s1

Synonyms: Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[ethyl bis(1-methylethyl)phosphoramidite]; 5'-O-DMTr-2'-O-Methyl-A(Bz) ethyl phosphoramidite

2'-O-Methyl Cytidine (n-bz) ethyl phosphoramidite

Description: 2'-O-Methyl Cytidine (n-bz) ethyl phosphoramidite is employed in oligonucleotide synthesis. It consists of a cytidine nucleoside modified with a 2'-O-Methyl group, protected with a benzoyl (n-bz) group, and coupled with an ethyl phosphoramidite. It facilitates the precise incorporation of modified cytidine into nucleotide chains during solid-phase synthesis, facilitating the design and synthesis of specialized oligonucleotides for use in molecular biology, genetics, diagnostics, and therapeutics.

CAT: BRP-01279

CAS: 179478-98-9

Molecular Formula: C46H55N4O9P

Molecular Weight: 838.93

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InChIKey: LZRBPQBDBLCFDX-ZRLRMURESA-N

CanonicalSMILES: O=C1N=C(C=CN1C2OC(COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)C(OP(OCC)N(C(C)C)C(C)C)C2OC)NC(=O)C=6C=CC=CC6

IUPAC Name: (2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl ethyl diisopropylphosphoramidite

InChI: InChI=1S/C46H55N4O9P/c1-9-57-60(50(31(2)3)32(4)5)59-41-39(58-44(42(41)55-8)49-29-28-40(48-45(49)52)47-43(51)33-16-12-10-13-17-33)30-56-46(34-18-14-11-15-19-34,35-20-24-37(53-6)25-21-35)36-22-26-38(54-7)27-23-36/h10-29,31-32,39,41-42,44H,9,30H2,1-8H3,(H,47,48,51,52)/t39-,41-,42-,44-,60?/m1/s1

Synonyms: Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[ethyl bis(1-methylethyl)phosphoramidite]; 5'-O-DMTr-2'-O-Methyl-C(Bz) ethyl phosphoramidite

2'-O-Methyl Guanosine (n-ibu) ethyl phosphoramidite

Description: 2'-O-Methyl Guanosine (n-ibu) ethyl phosphoramidite is utilized in oligonucleotide synthesis. It features a guanosine nucleoside modified with a 2'-O-Methyl group, protected with an isobutyryl (n-ibu) group, and coupled with an ethyl phosphoramidite. It enables controlled and efficient incorporation of modified guanosine into oligonucleotide sequences, crucial for tailored oligonucleotide design in various biological applications.

CAT: BRP-01280

CAS: 179478-99-0

Molecular Formula: C44H57N6O9P

Molecular Weight: 844.92

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InChIKey: WSJCHORSJDZQEN-FRQJXJFPSA-N

CanonicalSMILES: O=C1N=C(NC(=O)C(C)C)NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP(OCC)N(C(C)C)C(C)C)C3OC

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl ethyl diisopropylphosphoramidite

InChI: InChI=1S/C44H57N6O9P/c1-11-57-60(50(28(4)5)29(6)7)59-37-35(58-42(38(37)55-10)49-26-45-36-39(49)46-43(48-41(36)52)47-40(51)27(2)3)25-56-44(30-15-13-12-14-16-30,31-17-21-33(53-8)22-18-31)32-19-23-34(54-9)24-20-32/h12-24,26-29,35,37-38,42H,11,25H2,1-10H3,(H2,46,47,48,51,52)/t35-,37-,38-,42-,60?/m1/s1

Synonyms: Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-N-(2-methyl-1-oxopropyl)-, 3'-[ethyl bis(1-methylethyl)phosphoramidite]; 5'-O-DMTr-2'-O-Methyl-G(iBu) ethyl phosphoramidite

2'-O-Methyl Uridine ethyl phosphoramidite

Description: 2'-O-Methyl Uridine ethyl phosphoramidite is used in oligonucleotide synthesis. It comprises a uridine nucleoside modified with a 2'-O-Methyl group and coupled with an ethyl phosphoramidite. It facilitates the precise incorporation of modified uridine into nucleotide chains during solid-phase synthesis, facilitating the design and synthesis of specialized oligonucleotides for use in molecular biology, genetics, diagnostics, and therapeutics.

CAT: BRP-01281

CAS: 179479-00-6

Molecular Formula: C39H50N3O9P

Molecular Weight: 735.81

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InChIKey: COIUWZYORZFHID-SGXIJWRWSA-N

CanonicalSMILES: O=C1C=CN(C(=O)N1)C2OC(COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)C(OP(OCC)N(C(C)C)C(C)C)C2OC

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl ethyl diisopropylphosphoramidite

InChI: InChI=1S/C39H50N3O9P/c1-9-49-52(42(26(2)3)27(4)5)51-35-33(50-37(36(35)47-8)41-24-23-34(43)40-38(41)44)25-48-39(28-13-11-10-12-14-28,29-15-19-31(45-6)20-16-29)30-17-21-32(46-7)22-18-30/h10-24,26-27,33,35-37H,9,25H2,1-8H3,(H,40,43,44)/t33-,35-,36-,37-,52?/m1/s1

Synonyms: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[ethyl bis(1-methylethyl)phosphoramidite]; 5'-O-DMTr-2'-O-Methyl-U ethyl phosphoramidite

2'-O-Methyl Cytidine (n-ibu) p-methyl phosphonamidite

Description: 2'-O-Methyl Cytidine (n-ibu) p-methyl phosphonamidite is employed in oligonucleotide synthesis. It consists of a cytidine nucleoside modified with a 2'-O-Methyl group, protected with an isobutyryl (n-ibu) group, and coupled with a p-methyl phosphonamidite. It enables the precise incorporation of modified cytidine into nucleotide chains during solid-phase synthesis, facilitating the design and synthesis of specialized oligonucleotides for use in molecular biology, genetics, diagnostics, and therapeutics.

CAT: BRP-01282

CAS: 168752-56-5

Molecular Formula: C42H55N4O8P

Molecular Weight: 774.88

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InChIKey: ZWZQOFGHEWDFET-CMUCOHJHSA-N

CanonicalSMILES: CC(C)C(=O)NC1=NC(=O)N(C=C1)C2C(C(C(O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OP(C)N(C(C)C)C(C)C)OC

IUPAC Name: N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[[di(propan-2-yl)amino]-methylphosphanyl]oxy-3-methoxyoxolan-2-yl]-2-oxopyrimidin-4-yl]-2-methylpropanamide

InChI: InChI=1S/C42H55N4O8P/c1-27(2)39(47)43-36-24-25-45(41(48)44-36)40-38(51-9)37(54-55(10)46(28(3)4)29(5)6)35(53-40)26-52-42(30-14-12-11-13-15-30,31-16-20-33(49-7)21-17-31)32-18-22-34(50-8)23-19-32/h11-25,27-29,35,37-38,40H,26H2,1-10H3,(H,43,44,47,48)/t35-,37-,38-,40-,55?/m1/s1

Synonyms: Cytidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-N-(2-methyl-1-oxopropyl)-, 3'-[P-methyl-N,N-bis(1-methylethyl)phosphonamidate]; 5'-O-DMTr-2'-O-Methyl-C(iBu) p-methyl phosphonamidite

2'-O-propargyl Cytidine (n-bz) CED phosphoramidite

Description: 2'-O-Propargyl Cytidine (N-bz) CED phosphoramidite is a specialized reagent used in oligonucleotide synthesis. It consists of a cytidine nucleoside modified with a propargyl group at the 2' position and protected with a benzoyl (N-bz) group. Additionally, it contains a CED (2-cyanoethyl diisopropylphosphoramidite) moiety, which serves as a protecting group during the synthesis process. This phosphoramidite derivative allows for efficient and selective incorporation of the modified cytidine into the growing nucleotide chain during solid-phase synthesis. The presence of specific functional groups facilitates controlled chemical reactions, ensuring accurate and efficient synthesis of oligonucleotides for various applications in molecular biology, genetics, and diagnostics.

CAT: BRP-01287

CAS: 171486-60-5

Molecular Formula: C49H54N5O9P

Molecular Weight: 887.96

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InChIKey: AKMZLNQAQZVELP-LORUJQNASA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OCC#C)N2C=CC(=NC2=O)NC(=O)C3=CC=CC=C3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-prop-2-ynoxyoxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide

InChI: InChI=1S/C49H54N5O9P/c1-8-31-59-45-44(63-64(61-32-15-29-50)54(34(2)3)35(4)5)42(62-47(45)53-30-28-43(52-48(53)56)51-46(55)36-16-11-9-12-17-36)33-60-49(37-18-13-10-14-19-37,38-20-24-40(57-6)25-21-38)39-22-26-41(58-7)27-23-39/h1,9-14,16-28,30,34-35,42,44-45,47H,15,31-33H2,2-7H3,(H,51,52,55,56)/t42-,44-,45-,47-,64?/m1/s1

Synonyms: Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-2-propynyl-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; (2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(prop-2-yn-1-yloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; 2'-O-Propargyl C(Bz)-3'-phosphoramidite; DMTr-2'-O-propargyl-rC(Bz)-3'-CE-Phosphoramidite; N4-Bz-DMT-2'-O-propargyl-C-CE-Phosphoramidite

3'-O-Methyl Inosine CED phosphoramidite

Description: 3'-O-Methyl Inosine CED phosphoramidite is a modified inosine nucleotide used in oligonucleotide synthesis. It features a methyl group at the 3' position and a CED (cyanoethyl diisopropylamino) phosphoramidite group. This compound is utilized to create stable and functionalized RNA and DNA sequences, facilitating advanced research in genetics and molecular biology.

CAT: BRP-01293

Molecular Formula: C41H49N6O8P

Molecular Weight: 784.84

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InChIKey: RBSDCCNFMPGPFZ-HLHZJIEZSA-N

IUPAC Name: (2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxy-2-(6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C41H49N6O8P/c1-27(2)47(28(3)4)56(53-23-11-22-42)55-37-36(51-7)34(54-40(37)46-26-45-35-38(46)43-25-44-39(35)48)24-52-41(29-12-9-8-10-13-29,30-14-18-32(49-5)19-15-30)31-16-20-33(50-6)21-17-31/h8-10,12-21,25-28,34,36-37,40H,11,23-24H2,1-7H3,(H,43,44,48)/t34-,36-,37-,40-,56?/m1/s1

Synonyms: 5'-O-DMTr-3'-O-methylinosine-2'-O-CED-phosphoramidite; 3'-OMe I 2'-amidite; 5'-O-(4,4'-dimethoxytrityl)-3'-O-methylinosine-2'-cyanoethyl phosphoramidite; 3'-O-Me-I-2'-phosphoramidite; 3'-OMe-I Phosphoramidite

3'-O-propargyl Uridine CED phosphoramidite

Description: 3'-O-Propargyl Uridine CED phosphoramidite is a modified uridine nucleotide used in the synthesis of oligonucleotides. It features a propargyl group at the 3' position and a CED (cyanoethyl diisopropylamino) phosphoramidite group. This compound is employed to create functionalized and stable RNA and DNA sequences, supporting advanced research in genetics and molecular biology.

CAT: BRP-01294

Molecular Formula: C42H49N4O9P

Molecular Weight: 784.83

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InChIKey: ORUGVUBQAYTXET-CYSIDSPMSA-N

IUPAC Name: (2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-(prop-2-yn-1-yloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C42H49N4O9P/c1-8-26-51-38-36(54-40(45-25-23-37(47)44-41(45)48)39(38)55-56(53-27-12-24-43)46(29(2)3)30(4)5)28-52-42(31-13-10-9-11-14-31,32-15-19-34(49-6)20-16-32)33-17-21-35(50-7)22-18-33/h1,9-11,13-23,25,29-30,36,38-40H,12,26-28H2,2-7H3,(H,44,47,48)/t36-,38-,39-,40-,56?/m1/s1

Synonyms: 5'-O-DMTr-3'-O-propargyl-U-2'-CE-Phosphoramidite; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-2-propyn-1-yl-, 2'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

3'-O-propargyl Adenosine (n-bz) CED phosphoramidite

Description: 3'-O-Propargyl Adenosine (n-bz) CED phosphoramidite is a modified adenosine nucleotide used in the synthesis of oligonucleotides. It features a propargyl group at the 3' position and a benzoyl-protected adenine base, along with a CED (cyanoethyl diisopropylamino) phosphoramidite group. This compound is essential for creating functionalized and stable DNA and RNA sequences, facilitating advanced research in genetics and molecular biology.

CAT: BRP-01299

Molecular Formula: C50H54N7O8P

Molecular Weight: 911.98

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InChIKey: BUDCBFCJBVGQQL-XOMUZYEBSA-N

IUPAC Name: (2R,3R,4R,5R)-2-(6-benzamido-9H-purin-9-yl)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(prop-2-yn-1-yloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C50H54N7O8P/c1-8-29-61-44-42(31-62-50(37-18-13-10-14-19-37,38-20-24-40(59-6)25-21-38)39-22-26-41(60-7)27-23-39)64-49(45(44)65-66(63-30-15-28-51)57(34(2)3)35(4)5)56-33-54-43-46(52-32-53-47(43)56)55-48(58)36-16-11-9-12-17-36/h1,9-14,16-27,32-35,42,44-45,49H,15,29-31H2,2-7H3,(H,52,53,55,58)/t42-,44-,45-,49-,66?/m1/s1

Synonyms: 5'-O-DMTr-3'-O-propargyl-A(Bz)-2'-CE-Phosphoramidite

3'-O-propargyl Cytidine (n-bz) CED phosphoramidite

Description: 3'-O-Propargyl Cytidine (n-bz) CED phosphoramidite is a modified cytidine nucleotide used in oligonucleotide synthesis. It features a propargyl group at the 3' position and a benzoyl-protected cytosine base, along with a CED (cyanoethyl diisopropylamino) phosphoramidite group. This compound is utilized for creating functionalized and stable DNA and RNA sequences, supporting advanced genetic and molecular biology research.

CAT: BRP-01300

CAS: 1451256-03-3

Molecular Formula: C49H54N5O9P

Molecular Weight: 887.96

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InChIKey: JCADSQYVEOSYEC-LORUJQNASA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(C(OC1N2C=CC(=NC2=O)NC(=O)C3=CC=CC=C3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OCC#C

IUPAC Name: N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-4-prop-2-ynoxyoxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide

InChI: InChI=1S/C49H54N5O9P/c1-8-31-59-44-42(33-60-49(37-18-13-10-14-19-37,38-20-24-40(57-6)25-21-38)39-22-26-41(58-7)27-23-39)62-47(45(44)63-64(61-32-15-29-50)54(34(2)3)35(4)5)53-30-28-43(52-48(53)56)51-46(55)36-16-11-9-12-17-36/h1,9-14,16-28,30,34-35,42,44-45,47H,15,31-33H2,2-7H3,(H,51,52,55,56)/t42-,44-,45-,47-,64?/m1/s1

Synonyms: 5'-O-DMTr-3'-O-propargyl-C(Bz)-2'-CE-Phosphoramidite; Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-2-propyn-1-yl-, 2'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

3'-O-propargyl Guanosine (n-ibu) CED phosphoramidite

Description: 3'-O-Propargyl Guanosine (n-ibu) CED phosphoramidite is a modified guanosine nucleotide used in oligonucleotide synthesis. It features a propargyl group at the 3' position and an isobutyryl-protected guanine base, along with a CED (cyanoethyl diisopropylamino) phosphoramidite group. This compound is essential for creating functionalized and stable DNA and RNA sequences, facilitating advanced research in genetics and molecular biology.

CAT: BRP-01301

Molecular Formula: C47H56N7O9P

Molecular Weight: 893.96

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InChIKey: SDXBQKBJGQGUGW-VCGWOZLGSA-N

IUPAC Name: (2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-2-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(prop-2-yn-1-yloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C47H56N7O9P/c1-10-26-59-40-38(28-60-47(33-15-12-11-13-16-33,34-17-21-36(57-8)22-18-34)35-19-23-37(58-9)24-20-35)62-45(41(40)63-64(61-27-14-25-48)54(31(4)5)32(6)7)53-29-49-39-42(53)50-46(52-44(39)56)51-43(55)30(2)3/h1,11-13,15-24,29-32,38,40-41,45H,14,26-28H2,2-9H3,(H2,50,51,52,55,56)/t38-,40-,41-,45-,64?/m1/s1

Synonyms: 5'-O-DMTr-3'-O-propargyl-G(iBu)-2'-CE-Phosphoramidite

N4-Ethyl Cytidine CED phosphoramidite

Description: N4-Ethyl Cytidine CED phosphoramidite is a chemical compound used in the synthesis of nucleic acids, particularly RNA molecules. It consists of a cytidine nucleoside modified with a tert-butyldimethylsilyl (TBDMS) group at the 2' position and an ethyl group at the N4 position. Additionally, it contains a CED (2-cyanoethyl diisopropylphosphoramidite) moiety, which serves as a protecting group during the synthesis process. This phosphoramidite derivative allows for efficient and selective incorporation of the modified cytidine into the growing RNA chain during solid-phase synthesis, enabling researchers to tailor RNA molecules with specific functionalities for various biological and therapeutic applications.

CAT: BRP-01303

Molecular Formula: C47H66N5O8PSi

Molecular Weight: 888.12

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InChIKey: YLWRTGHURVFSCS-UODQAQMXSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(4-(ethylamino)-2-oxopyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C47H66N5O8PSi/c1-13-49-41-28-30-51(45(53)50-41)44-43(60-62(11,12)46(6,7)8)42(59-61(57-31-17-29-48)52(33(2)3)34(4)5)40(58-44)32-56-47(35-18-15-14-16-19-35,36-20-24-38(54-9)25-21-36)37-22-26-39(55-10)27-23-37/h14-16,18-28,30,33-34,40,42-44H,13,17,31-32H2,1-12H3,(H,49,50,53)/t40-,42-,43-,44-,61?/m1/s1

Synonyms: 2'-TBDMS Cytidine(ethyl) 3'-CE-phosphoramidite; N4-Ethyl Cytidine 3'-tBDSilyl CED phosphoramidite; N4-Ethyl Cytidine 2'-tBDSilyl CED phosphoramidite

4-Thio Uridine CED phosphoramidite

Description: 4-Thio Uridine CED phosphoramidite is a compound used in the chemical synthesis of nucleic acids, particularly RNA molecules. It consists of a uridine nucleoside modified with a 2'-TBDMS (tert-butyldimethylsilyl) group at the 2' position and a 4-S-(2-cyanoethyl) modification. Additionally, it contains a CE (2-cyanoethyl) phosphoramidite moiety, which serves as a protecting group during the synthesis process. This phosphoramidite derivative allows for efficient and selective incorporation of the modified uridine into the growing RNA chain during solid-phase synthesis, enabling researchers to tailor RNA molecules with specific functionalities for various biological and therapeutic applications.

CAT: BRP-01305

CAS: 154665-04-0

Molecular Formula: C48H64N5O8PSSi

Molecular Weight: 930.18

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InChIKey: DKQKZAVAXOCNNU-CRHOWCKESA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=CC(=NC2=O)SCCC#N)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-5-[4-(2-cyanoethylsulfanyl)-2-oxopyrimidin-1-yl]oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C48H64N5O8PSSi/c1-34(2)53(35(3)4)62(58-31-15-28-49)60-43-41(59-45(44(43)61-64(10,11)47(5,6)7)52-30-27-42(51-46(52)54)63-32-16-29-50)33-57-48(36-17-13-12-14-18-36,37-19-23-39(55-8)24-20-37)38-21-25-40(56-9)26-22-38/h12-14,17-27,30,34-35,41,43-45H,15-16,31-33H2,1-11H3/t41-,43-,44-,45-,62?/m1/s1

Synonyms: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-4-S-(2-cyanoethyl)-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-4-thio-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-4-S-(2-cyanoethyl)-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-4-thio-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; 4-S-(2-cyanoethyl)-2'-TBDMS-U 3'-CE-phosphoramidite

MMT-2'-tBDSilyl Adenosine (n-bz) CED phosphoramidite

Description: MMT-2'-tBDSilyl Adenosine (n-bz) CED phosphoramidite is a specialized reagent utilized in oligonucleotide synthesis. It comprises an adenosine nucleoside modified with a 2'-tBDSilyl group and protected with a benzoyl (n-bz) group. Additionally, it contains a CED (2-cyanoethyl diisopropylphosphoramidite) moiety, which serves as a protecting group during the synthesis process. The MMT (Monomethoxytrityl) group is typically used for temporary protection of hydroxyl groups in nucleosides. This phosphoramidite derivative enables efficient and selective incorporation of the modified adenosine into the growing nucleotide chain during solid-phase synthesis. It plays a crucial role in the design and synthesis of modified oligonucleotides for various applications in molecular biology, diagnostics, and therapeutics.

CAT: BRP-01320

CAS: 135711-69-2

Molecular Formula: C52H64N7O7PSi

Molecular Weight: 958.17

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InChIKey: VMFYLWGANHVWAU-LTMMGAFGSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=C(C=C7)OC

IUPAC Name: N-[9-[(2R,3R,4R,5R)-3-[tert-butyl(dimethyl)silyl]oxy-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-5-[[(4-methoxyphenyl)-diphenylmethoxy]methyl]oxolan-2-yl]purin-6-yl]benzamide

InChI: InChI=1S/C52H64N7O7PSi/c1-36(2)59(37(3)4)67(63-32-20-31-53)65-45-43(33-62-52(39-23-16-12-17-24-39,40-25-18-13-19-26-40)41-27-29-42(61-8)30-28-41)64-50(46(45)66-68(9,10)51(5,6)7)58-35-56-44-47(54-34-55-48(44)58)57-49(60)38-21-14-11-15-22-38/h11-19,21-30,34-37,43,45-46,50H,20,32-33H2,1-10H3,(H,54,55,57,60)/t43-,45-,46-,50-,67?/m1/s1

Synonyms: 5'-MMT-2'-TBDMS A(Bz) 3'-CE phosphoramidite; Adenosine, N-benzoyl-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-5'-O-[(4-methoxyphenyl)diphenylmethyl]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

MMT-2'-tBDSilyl Guanosine (n-ibu) CED phosphoramidite

Description: MMT-2'-tBDSilyl Guanosine (n-ibu) CED phosphoramidite is a specialized reagent used in oligonucleotide synthesis. It consists of a guanosine nucleoside modified with a 2'-tBDSilyl group and protected with an isobutyryl (n-ibu) group. Additionally, it contains a CED (2-cyanoethyl diisopropylphosphoramidite) moiety, which acts as a protecting group during the synthesis process. The MMT (Monomethoxytrityl) group is typically employed for temporary protection of hydroxyl groups in nucleosides. This phosphoramidite derivative facilitates efficient and selective incorporation of the modified guanosine into the growing nucleotide chain during solid-phase synthesis. It is essential for designing and synthesizing modified oligonucleotides for various applications in molecular biology, diagnostics, and therapeutics.

CAT: BRP-01321

Molecular Formula: C49H66N7O8PSi

Molecular Weight: 940.15

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InChIKey: XJHPFJYSMMSOCC-VKFKYRIUSA-N

IUPAC Name: (2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-(((4-methoxyphenyl)diphenylmethoxy)methyl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C49H66N7O8PSi/c1-32(2)44(57)53-47-52-43-40(45(58)54-47)51-31-55(43)46-42(64-66(11,12)48(7,8)9)41(63-65(61-29-19-28-50)56(33(3)4)34(5)6)39(62-46)30-60-49(35-20-15-13-16-21-35,36-22-17-14-18-23-36)37-24-26-38(59-10)27-25-37/h13-18,20-27,31-34,39,41-42,46H,19,29-30H2,1-12H3,(H2,52,53,54,57,58)/t39-,41-,42-,46-,65?/m1/s1

Synonyms: 5'-MMT-2'-TBDMS G(iBu) 3'-CE phosphoramidite

MMT-2'-O-Methyl Guanosine (n-ibu) CED phosphoramidite

2'-O-Methyl Cytidine (N-PAC) 3'-O-BMEG phosphoramidite

2'-O-Methyl Guanosine (N-iPrPAC) 3'-O-BMEG phosphoramidite

2'-O-Methyl Uridine 3'-O-BMEG phosphoramidite

2'-O-Methyl Adenosine (N-PAC) 3'-O-BMEG phosphoramidite

2'-O-Methyl Adenosine (n-bz) ethyl phosphoramidite

2'-O-Methyl Cytidine (n-bz) ethyl phosphoramidite

2'-O-Methyl Guanosine (n-ibu) ethyl phosphoramidite

2'-O-Methyl Uridine ethyl phosphoramidite

2'-O-Methyl Cytidine (n-ibu) p-methyl phosphonamidite

2'-O-propargyl Cytidine (n-bz) CED phosphoramidite

3'-O-Methyl Inosine CED phosphoramidite

3'-O-propargyl Uridine CED phosphoramidite

3'-O-propargyl Adenosine (n-bz) CED phosphoramidite

3'-O-propargyl Cytidine (n-bz) CED phosphoramidite

3'-O-propargyl Guanosine (n-ibu) CED phosphoramidite

N4-Ethyl Cytidine CED phosphoramidite

4-Thio Uridine CED phosphoramidite

MMT-2'-tBDSilyl Adenosine (n-bz) CED phosphoramidite

MMT-2'-tBDSilyl Guanosine (n-ibu) CED phosphoramidite

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