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2'-Modified Phosphoramidites
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(19/19) Base Protected Phosphoramidites (375/375) Dye Phosphoramidites
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(94/94) PMO Phosphoramidates and Derivatives (33/33) PseudoUridine Phosphoramidite
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2'-O-Methyl Cytidine (n-bz) ethyl phosphoramidite
Description: 2'-O-Methyl Cytidine (n-bz) ethyl phosphoramidite is employed in oligonucleotide synthesis. It consists of a cytidine nucleoside modified with a 2'-O-Methyl group, protected with a benzoyl (n-bz) group, and coupled with an ethyl phosphoramidite. It facilitates the precise incorporation of modified cytidine into nucleotide chains during solid-phase synthesis, facilitating the design and synthesis of specialized oligonucleotides for use in molecular biology, genetics, diagnostics, and therapeutics.
CAT: BRP-01279
CAS: 179478-98-9
MF: C46H55N4O9P
MF: 838.93
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InChIKey: LZRBPQBDBLCFDX-ZRLRMURESA-N
CanonicalSMILES: O=C1N=C(C=CN1C2OC(COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)C(OP(OCC)N(C(C)C)C(C)C)C2OC)NC(=O)C=6C=CC=CC6
IUPAC Name: (2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl ethyl diisopropylphosphoramidite
InChI: InChI=1S/C46H55N4O9P/c1-9-57-60(50(31(2)3)32(4)5)59-41-39(58-44(42(41)55-8)49-29-28-40(48-45(49)52)47-43(51)33-16-12-10-13-17-33)30-56-46(34-18-14-11-15-19-34,35-20-24-37(53-6)25-21-35)36-22-26-38(54-7)27-23-36/h10-29,31-32,39,41-42,44H,9,30H2,1-8H3,(H,47,48,51,52)/t39-,41-,42-,44-,60?/m1/s1
Synonyms: Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[ethyl bis(1-methylethyl)phosphoramidite]; 5'-O-DMTr-2'-O-Methyl-C(Bz) ethyl phosphoramidite
2'-O-Methyl Guanosine (n-ibu) ethyl phosphoramidite
Description: 2'-O-Methyl Guanosine (n-ibu) ethyl phosphoramidite is utilized in oligonucleotide synthesis. It features a guanosine nucleoside modified with a 2'-O-Methyl group, protected with an isobutyryl (n-ibu) group, and coupled with an ethyl phosphoramidite. It enables controlled and efficient incorporation of modified guanosine into oligonucleotide sequences, crucial for tailored oligonucleotide design in various biological applications.
CAT: BRP-01280
CAS: 179478-99-0
MF: C44H57N6O9P
MF: 844.92
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InChIKey: WSJCHORSJDZQEN-FRQJXJFPSA-N
CanonicalSMILES: O=C1N=C(NC(=O)C(C)C)NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OP(OCC)N(C(C)C)C(C)C)C3OC
IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl ethyl diisopropylphosphoramidite
InChI: InChI=1S/C44H57N6O9P/c1-11-57-60(50(28(4)5)29(6)7)59-37-35(58-42(38(37)55-10)49-26-45-36-39(49)46-43(48-41(36)52)47-40(51)27(2)3)25-56-44(30-15-13-12-14-16-30,31-17-21-33(53-8)22-18-31)32-19-23-34(54-9)24-20-32/h12-24,26-29,35,37-38,42H,11,25H2,1-10H3,(H2,46,47,48,51,52)/t35-,37-,38-,42-,60?/m1/s1
Synonyms: Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-N-(2-methyl-1-oxopropyl)-, 3'-[ethyl bis(1-methylethyl)phosphoramidite]; 5'-O-DMTr-2'-O-Methyl-G(iBu) ethyl phosphoramidite
2'-O-Methyl Uridine ethyl phosphoramidite
Description: 2'-O-Methyl Uridine ethyl phosphoramidite is used in oligonucleotide synthesis. It comprises a uridine nucleoside modified with a 2'-O-Methyl group and coupled with an ethyl phosphoramidite. It facilitates the precise incorporation of modified uridine into nucleotide chains during solid-phase synthesis, facilitating the design and synthesis of specialized oligonucleotides for use in molecular biology, genetics, diagnostics, and therapeutics.
CAT: BRP-01281
CAS: 179479-00-6
MF: C39H50N3O9P
MF: 735.81
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InChIKey: COIUWZYORZFHID-SGXIJWRWSA-N
CanonicalSMILES: O=C1C=CN(C(=O)N1)C2OC(COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)C(OP(OCC)N(C(C)C)C(C)C)C2OC
IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl ethyl diisopropylphosphoramidite
InChI: InChI=1S/C39H50N3O9P/c1-9-49-52(42(26(2)3)27(4)5)51-35-33(50-37(36(35)47-8)41-24-23-34(43)40-38(41)44)25-48-39(28-13-11-10-12-14-28,29-15-19-31(45-6)20-16-29)30-17-21-32(46-7)22-18-30/h10-24,26-27,33,35-37H,9,25H2,1-8H3,(H,40,43,44)/t33-,35-,36-,37-,52?/m1/s1
Synonyms: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[ethyl bis(1-methylethyl)phosphoramidite]; 5'-O-DMTr-2'-O-Methyl-U ethyl phosphoramidite
2'-O-Methyl Cytidine (n-ibu) p-methyl phosphonamidite
Description: 2'-O-Methyl Cytidine (n-ibu) p-methyl phosphonamidite is employed in oligonucleotide synthesis. It consists of a cytidine nucleoside modified with a 2'-O-Methyl group, protected with an isobutyryl (n-ibu) group, and coupled with a p-methyl phosphonamidite. It enables the precise incorporation of modified cytidine into nucleotide chains during solid-phase synthesis, facilitating the design and synthesis of specialized oligonucleotides for use in molecular biology, genetics, diagnostics, and therapeutics.
CAT: BRP-01282
CAS: 168752-56-5
MF: C42H55N4O8P
MF: 774.88
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InChIKey: ZWZQOFGHEWDFET-CMUCOHJHSA-N
CanonicalSMILES: CC(C)C(=O)NC1=NC(=O)N(C=C1)C2C(C(C(O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OP(C)N(C(C)C)C(C)C)OC
IUPAC Name: N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[[di(propan-2-yl)amino]-methylphosphanyl]oxy-3-methoxyoxolan-2-yl]-2-oxopyrimidin-4-yl]-2-methylpropanamide
InChI: InChI=1S/C42H55N4O8P/c1-27(2)39(47)43-36-24-25-45(41(48)44-36)40-38(51-9)37(54-55(10)46(28(3)4)29(5)6)35(53-40)26-52-42(30-14-12-11-13-15-30,31-16-20-33(49-7)21-17-31)32-18-22-34(50-8)23-19-32/h11-25,27-29,35,37-38,40H,26H2,1-10H3,(H,43,44,47,48)/t35-,37-,38-,40-,55?/m1/s1
Synonyms: Cytidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-N-(2-methyl-1-oxopropyl)-, 3'-[P-methyl-N,N-bis(1-methylethyl)phosphonamidate]; 5'-O-DMTr-2'-O-Methyl-C(iBu) p-methyl phosphonamidite
2'-O-propargyl Cytidine (n-bz) CED phosphoramidite
Description: 2'-O-Propargyl Cytidine (N-bz) CED phosphoramidite is a specialized reagent used in oligonucleotide synthesis. It consists of a cytidine nucleoside modified with a propargyl group at the 2' position and protected with a benzoyl (N-bz) group. Additionally, it contains a CED (2-cyanoethyl diisopropylphosphoramidite) moiety, which serves as a protecting group during the synthesis process. This phosphoramidite derivative allows for efficient and selective incorporation of the modified cytidine into the growing nucleotide chain during solid-phase synthesis. The presence of specific functional groups facilitates controlled chemical reactions, ensuring accurate and efficient synthesis of oligonucleotides for various applications in molecular biology, genetics, and diagnostics.
CAT: BRP-01287
CAS: 171486-60-5
MF: C49H54N5O9P
MF: 887.96
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InChIKey: AKMZLNQAQZVELP-LORUJQNASA-N
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OCC#C)N2C=CC(=NC2=O)NC(=O)C3=CC=CC=C3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC
IUPAC Name: N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-prop-2-ynoxyoxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide
InChI: InChI=1S/C49H54N5O9P/c1-8-31-59-45-44(63-64(61-32-15-29-50)54(34(2)3)35(4)5)42(62-47(45)53-30-28-43(52-48(53)56)51-46(55)36-16-11-9-12-17-36)33-60-49(37-18-13-10-14-19-37,38-20-24-40(57-6)25-21-38)39-22-26-41(58-7)27-23-39/h1,9-14,16-28,30,34-35,42,44-45,47H,15,31-33H2,2-7H3,(H,51,52,55,56)/t42-,44-,45-,47-,64?/m1/s1
Synonyms: Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-2-propynyl-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; (2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(prop-2-yn-1-yloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; 2'-O-Propargyl C(Bz)-3'-phosphoramidite; DMTr-2'-O-propargyl-rC(Bz)-3'-CE-Phosphoramidite; N4-Bz-DMT-2'-O-propargyl-C-CE-Phosphoramidite
3'-O-Methyl Inosine CED phosphoramidite
Description: 3'-O-Methyl Inosine CED phosphoramidite is a modified inosine nucleotide used in oligonucleotide synthesis. It features a methyl group at the 3' position and a CED (cyanoethyl diisopropylamino) phosphoramidite group. This compound is utilized to create stable and functionalized RNA and DNA sequences, facilitating advanced research in genetics and molecular biology.
CAT: BRP-01293
MF: C41H49N6O8P
MF: 784.84
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InChIKey: RBSDCCNFMPGPFZ-HLHZJIEZSA-N
IUPAC Name: (2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxy-2-(6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C41H49N6O8P/c1-27(2)47(28(3)4)56(53-23-11-22-42)55-37-36(51-7)34(54-40(37)46-26-45-35-38(46)43-25-44-39(35)48)24-52-41(29-12-9-8-10-13-29,30-14-18-32(49-5)19-15-30)31-16-20-33(50-6)21-17-31/h8-10,12-21,25-28,34,36-37,40H,11,23-24H2,1-7H3,(H,43,44,48)/t34-,36-,37-,40-,56?/m1/s1
Synonyms: 5'-O-DMTr-3'-O-methylinosine-2'-O-CED-phosphoramidite; 3'-OMe I 2'-amidite; 5'-O-(4,4'-dimethoxytrityl)-3'-O-methylinosine-2'-cyanoethyl phosphoramidite; 3'-O-Me-I-2'-phosphoramidite; 3'-OMe-I Phosphoramidite
3'-O-propargyl Uridine CED phosphoramidite
Description: 3'-O-Propargyl Uridine CED phosphoramidite is a modified uridine nucleotide used in the synthesis of oligonucleotides. It features a propargyl group at the 3' position and a CED (cyanoethyl diisopropylamino) phosphoramidite group. This compound is employed to create functionalized and stable RNA and DNA sequences, supporting advanced research in genetics and molecular biology.
CAT: BRP-01294
MF: C42H49N4O9P
MF: 784.83
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InChIKey: ORUGVUBQAYTXET-CYSIDSPMSA-N
IUPAC Name: (2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-(prop-2-yn-1-yloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C42H49N4O9P/c1-8-26-51-38-36(54-40(45-25-23-37(47)44-41(45)48)39(38)55-56(53-27-12-24-43)46(29(2)3)30(4)5)28-52-42(31-13-10-9-11-14-31,32-15-19-34(49-6)20-16-32)33-17-21-35(50-7)22-18-33/h1,9-11,13-23,25,29-30,36,38-40H,12,26-28H2,2-7H3,(H,44,47,48)/t36-,38-,39-,40-,56?/m1/s1
Synonyms: 5'-O-DMTr-3'-O-propargyl-U-2'-CE-Phosphoramidite; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-2-propyn-1-yl-, 2'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
-ced-phosphoramidite.gif)
3'-O-propargyl Adenosine (n-bz) CED phosphoramidite
Description: 3'-O-Propargyl Adenosine (n-bz) CED phosphoramidite is a modified adenosine nucleotide used in the synthesis of oligonucleotides. It features a propargyl group at the 3' position and a benzoyl-protected adenine base, along with a CED (cyanoethyl diisopropylamino) phosphoramidite group. This compound is essential for creating functionalized and stable DNA and RNA sequences, facilitating advanced research in genetics and molecular biology.
CAT: BRP-01299
MF: C50H54N7O8P
MF: 911.98
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InChIKey: BUDCBFCJBVGQQL-XOMUZYEBSA-N
IUPAC Name: (2R,3R,4R,5R)-2-(6-benzamido-9H-purin-9-yl)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(prop-2-yn-1-yloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C50H54N7O8P/c1-8-29-61-44-42(31-62-50(37-18-13-10-14-19-37,38-20-24-40(59-6)25-21-38)39-22-26-41(60-7)27-23-39)64-49(45(44)65-66(63-30-15-28-51)57(34(2)3)35(4)5)56-33-54-43-46(52-32-53-47(43)56)55-48(58)36-16-11-9-12-17-36/h1,9-14,16-27,32-35,42,44-45,49H,15,29-31H2,2-7H3,(H,52,53,55,58)/t42-,44-,45-,49-,66?/m1/s1
Synonyms: 5'-O-DMTr-3'-O-propargyl-A(Bz)-2'-CE-Phosphoramidite
3'-O-propargyl Cytidine (n-bz) CED phosphoramidite
Description: 3'-O-Propargyl Cytidine (n-bz) CED phosphoramidite is a modified cytidine nucleotide used in oligonucleotide synthesis. It features a propargyl group at the 3' position and a benzoyl-protected cytosine base, along with a CED (cyanoethyl diisopropylamino) phosphoramidite group. This compound is utilized for creating functionalized and stable DNA and RNA sequences, supporting advanced genetic and molecular biology research.
CAT: BRP-01300
CAS: 1451256-03-3
MF: C49H54N5O9P
MF: 887.96
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InChIKey: JCADSQYVEOSYEC-LORUJQNASA-N
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(C(OC1N2C=CC(=NC2=O)NC(=O)C3=CC=CC=C3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OCC#C
IUPAC Name: N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-4-prop-2-ynoxyoxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide
InChI: InChI=1S/C49H54N5O9P/c1-8-31-59-44-42(33-60-49(37-18-13-10-14-19-37,38-20-24-40(57-6)25-21-38)39-22-26-41(58-7)27-23-39)62-47(45(44)63-64(61-32-15-29-50)54(34(2)3)35(4)5)53-30-28-43(52-48(53)56)51-46(55)36-16-11-9-12-17-36/h1,9-14,16-28,30,34-35,42,44-45,47H,15,31-33H2,2-7H3,(H,51,52,55,56)/t42-,44-,45-,47-,64?/m1/s1
Synonyms: 5'-O-DMTr-3'-O-propargyl-C(Bz)-2'-CE-Phosphoramidite; Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-2-propyn-1-yl-, 2'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
-ced-phosphoramidite.gif)
3'-O-propargyl Guanosine (n-ibu) CED phosphoramidite
Description: 3'-O-Propargyl Guanosine (n-ibu) CED phosphoramidite is a modified guanosine nucleotide used in oligonucleotide synthesis. It features a propargyl group at the 3' position and an isobutyryl-protected guanine base, along with a CED (cyanoethyl diisopropylamino) phosphoramidite group. This compound is essential for creating functionalized and stable DNA and RNA sequences, facilitating advanced research in genetics and molecular biology.
CAT: BRP-01301
MF: C47H56N7O9P
MF: 893.96
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InChIKey: SDXBQKBJGQGUGW-VCGWOZLGSA-N
IUPAC Name: (2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-2-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(prop-2-yn-1-yloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C47H56N7O9P/c1-10-26-59-40-38(28-60-47(33-15-12-11-13-16-33,34-17-21-36(57-8)22-18-34)35-19-23-37(58-9)24-20-35)62-45(41(40)63-64(61-27-14-25-48)54(31(4)5)32(6)7)53-29-49-39-42(53)50-46(52-44(39)56)51-43(55)30(2)3/h1,11-13,15-24,29-32,38,40-41,45H,14,26-28H2,2-9H3,(H2,50,51,52,55,56)/t38-,40-,41-,45-,64?/m1/s1
Synonyms: 5'-O-DMTr-3'-O-propargyl-G(iBu)-2'-CE-Phosphoramidite
N4-Ethyl Cytidine CED phosphoramidite
Description: N4-Ethyl Cytidine CED phosphoramidite is a chemical compound used in the synthesis of nucleic acids, particularly RNA molecules. It consists of a cytidine nucleoside modified with a tert-butyldimethylsilyl (TBDMS) group at the 2' position and an ethyl group at the N4 position. Additionally, it contains a CED (2-cyanoethyl diisopropylphosphoramidite) moiety, which serves as a protecting group during the synthesis process. This phosphoramidite derivative allows for efficient and selective incorporation of the modified cytidine into the growing RNA chain during solid-phase synthesis, enabling researchers to tailor RNA molecules with specific functionalities for various biological and therapeutic applications.
CAT: BRP-01303
MF: C47H66N5O8PSi
MF: 888.12
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InChIKey: YLWRTGHURVFSCS-UODQAQMXSA-N
IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(4-(ethylamino)-2-oxopyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C47H66N5O8PSi/c1-13-49-41-28-30-51(45(53)50-41)44-43(60-62(11,12)46(6,7)8)42(59-61(57-31-17-29-48)52(33(2)3)34(4)5)40(58-44)32-56-47(35-18-15-14-16-19-35,36-20-24-38(54-9)25-21-36)37-22-26-39(55-10)27-23-37/h14-16,18-28,30,33-34,40,42-44H,13,17,31-32H2,1-12H3,(H,49,50,53)/t40-,42-,43-,44-,61?/m1/s1
Synonyms: 2'-TBDMS Cytidine(ethyl) 3'-CE-phosphoramidite; N4-Ethyl Cytidine 3'-tBDSilyl CED phosphoramidite; N4-Ethyl Cytidine 2'-tBDSilyl CED phosphoramidite
4-Thio Uridine CED phosphoramidite
Description: 4-Thio Uridine CED phosphoramidite is a compound used in the chemical synthesis of nucleic acids, particularly RNA molecules. It consists of a uridine nucleoside modified with a 2'-TBDMS (tert-butyldimethylsilyl) group at the 2' position and a 4-S-(2-cyanoethyl) modification. Additionally, it contains a CE (2-cyanoethyl) phosphoramidite moiety, which serves as a protecting group during the synthesis process. This phosphoramidite derivative allows for efficient and selective incorporation of the modified uridine into the growing RNA chain during solid-phase synthesis, enabling researchers to tailor RNA molecules with specific functionalities for various biological and therapeutic applications.
CAT: BRP-01305
CAS: 154665-04-0
MF: C48H64N5O8PSSi
MF: 930.18
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InChIKey: DKQKZAVAXOCNNU-CRHOWCKESA-N
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=CC(=NC2=O)SCCC#N)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC
IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-5-[4-(2-cyanoethylsulfanyl)-2-oxopyrimidin-1-yl]oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
InChI: InChI=1S/C48H64N5O8PSSi/c1-34(2)53(35(3)4)62(58-31-15-28-49)60-43-41(59-45(44(43)61-64(10,11)47(5,6)7)52-30-27-42(51-46(52)54)63-32-16-29-50)33-57-48(36-17-13-12-14-18-36,37-19-23-39(55-8)24-20-37)38-21-25-40(56-9)26-22-38/h12-14,17-27,30,34-35,41,43-45H,15-16,31-33H2,1-11H3/t41-,43-,44-,45-,62?/m1/s1
Synonyms: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-4-S-(2-cyanoethyl)-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-4-thio-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-4-S-(2-cyanoethyl)-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-4-thio-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; 4-S-(2-cyanoethyl)-2'-TBDMS-U 3'-CE-phosphoramidite
MMT-2'-tBDSilyl Adenosine (n-bz) CED phosphoramidite
Description: MMT-2'-tBDSilyl Adenosine (n-bz) CED phosphoramidite is a specialized reagent utilized in oligonucleotide synthesis. It comprises an adenosine nucleoside modified with a 2'-tBDSilyl group and protected with a benzoyl (n-bz) group. Additionally, it contains a CED (2-cyanoethyl diisopropylphosphoramidite) moiety, which serves as a protecting group during the synthesis process. The MMT (Monomethoxytrityl) group is typically used for temporary protection of hydroxyl groups in nucleosides. This phosphoramidite derivative enables efficient and selective incorporation of the modified adenosine into the growing nucleotide chain during solid-phase synthesis. It plays a crucial role in the design and synthesis of modified oligonucleotides for various applications in molecular biology, diagnostics, and therapeutics.
CAT: BRP-01320
CAS: 135711-69-2
MF: C52H64N7O7PSi
MF: 958.17
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InChIKey: VMFYLWGANHVWAU-LTMMGAFGSA-N
CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=C(C=C7)OC
IUPAC Name: N-[9-[(2R,3R,4R,5R)-3-[tert-butyl(dimethyl)silyl]oxy-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-5-[[(4-methoxyphenyl)-diphenylmethoxy]methyl]oxolan-2-yl]purin-6-yl]benzamide
InChI: InChI=1S/C52H64N7O7PSi/c1-36(2)59(37(3)4)67(63-32-20-31-53)65-45-43(33-62-52(39-23-16-12-17-24-39,40-25-18-13-19-26-40)41-27-29-42(61-8)30-28-41)64-50(46(45)66-68(9,10)51(5,6)7)58-35-56-44-47(54-34-55-48(44)58)57-49(60)38-21-14-11-15-22-38/h11-19,21-30,34-37,43,45-46,50H,20,32-33H2,1-10H3,(H,54,55,57,60)/t43-,45-,46-,50-,67?/m1/s1
Synonyms: 5'-MMT-2'-TBDMS A(Bz) 3'-CE phosphoramidite; Adenosine, N-benzoyl-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-5'-O-[(4-methoxyphenyl)diphenylmethyl]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]
-ced-phosphoramidite.gif)
MMT-2'-tBDSilyl Guanosine (n-ibu) CED phosphoramidite
Description: MMT-2'-tBDSilyl Guanosine (n-ibu) CED phosphoramidite is a specialized reagent used in oligonucleotide synthesis. It consists of a guanosine nucleoside modified with a 2'-tBDSilyl group and protected with an isobutyryl (n-ibu) group. Additionally, it contains a CED (2-cyanoethyl diisopropylphosphoramidite) moiety, which acts as a protecting group during the synthesis process. The MMT (Monomethoxytrityl) group is typically employed for temporary protection of hydroxyl groups in nucleosides. This phosphoramidite derivative facilitates efficient and selective incorporation of the modified guanosine into the growing nucleotide chain during solid-phase synthesis. It is essential for designing and synthesizing modified oligonucleotides for various applications in molecular biology, diagnostics, and therapeutics.
CAT: BRP-01321
MF: C49H66N7O8PSi
MF: 940.15
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InChIKey: XJHPFJYSMMSOCC-VKFKYRIUSA-N
IUPAC Name: (2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-(((4-methoxyphenyl)diphenylmethoxy)methyl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C49H66N7O8PSi/c1-32(2)44(57)53-47-52-43-40(45(58)54-47)51-31-55(43)46-42(64-66(11,12)48(7,8)9)41(63-65(61-29-19-28-50)56(33(3)4)34(5)6)39(62-46)30-60-49(35-20-15-13-16-21-35,36-22-17-14-18-23-36)37-24-26-38(59-10)27-25-37/h13-18,20-27,31-34,39,41-42,46H,19,29-30H2,1-12H3,(H2,52,53,54,57,58)/t39-,41-,42-,46-,65?/m1/s1
Synonyms: 5'-MMT-2'-TBDMS G(iBu) 3'-CE phosphoramidite
-ced-phosphoramidite.gif)
MMT-2'-tBDSilyl Guanosine (n-PAC) CED phosphoramidite
Description: MMT-2'-tBDSilyl Guanosine (n-PAC) CED phosphoramidite is used in oligonucleotide synthesis. It comprises a guanosine nucleoside modified with a 2'-tBDSilyl group and protected with a PAC (phenoxyacetyl) group. Additionally, it contains a CED (2-cyanoethyl diisopropylphosphoramidite) moiety, serving as a protecting group during synthesis. The MMT (Monomethoxytrityl) group temporarily shields hydroxyl groups in nucleosides. This phosphoramidite derivative facilitates efficient and selective incorporation of the modified guanosine into oligonucleotide sequences during solid-phase synthesis, crucial for tailored oligonucleotide design in various biological applications.
CAT: BRP-01322
MF: C53H66N7O9PSi
MF: 1004.19
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InChIKey: MBHPUJWVPHGMKR-NTWXHQQMSA-N
IUPAC Name: (2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-2-(((4-methoxyphenyl)diphenylmethoxy)methyl)-5-(6-oxo-2-(2-phenoxyacetamido)-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C53H66N7O9PSi/c1-36(2)60(37(3)4)70(66-32-20-31-54)68-46-43(33-65-53(38-21-14-11-15-22-38,39-23-16-12-17-24-39)40-27-29-41(63-8)30-28-40)67-50(47(46)69-71(9,10)52(5,6)7)59-35-55-45-48(59)57-51(58-49(45)62)56-44(61)34-64-42-25-18-13-19-26-42/h11-19,21-30,35-37,43,46-47,50H,20,32-34H2,1-10H3,(H2,56,57,58,61,62)/t43-,46-,47-,50-,70?/m1/s1
Synonyms: 5'-MMT-2'-TBDMS G(Pac) 3'-CE phosphoramidite
-ced-phosphoramidite.gif)
MMT-2'-tBDSilyl Adenosine (n-PAC) CED phosphoramidite
Description: MMT-2'-tBDSilyl Adenosine (n-PAC) CED phosphoramidite is utilized in oligonucleotide synthesis. It involves an adenosine nucleoside modified with a 2'-tBDSilyl group and protected with a PAC (phenoxyacetyl) group, coupled with a CED (2-cyanoethyl diisopropylphosphoramidite) moiety. The MMT (Monomethoxytrityl) group is typically used for temporary protection of hydroxyl groups in nucleosides. This phosphoramidite derivative enables efficient and selective incorporation of the modified adenosine into oligonucleotide sequences during solid-phase synthesis, essential for customized oligonucleotide design in various biological applications.
CAT: BRP-01323
MF: C53H66N7O8PSi
MF: 988.19
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InChIKey: HVOWVANSACUJFY-RPWAFYAOSA-N
IUPAC Name: (2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-2-(((4-methoxyphenyl)diphenylmethoxy)methyl)-5-(6-(2-phenoxyacetamido)-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C53H66N7O8PSi/c1-37(2)60(38(3)4)69(65-32-20-31-54)67-47-44(33-64-53(39-21-14-11-15-22-39,40-23-16-12-17-24-40)41-27-29-42(62-8)30-28-41)66-51(48(47)68-70(9,10)52(5,6)7)59-36-57-46-49(55-35-56-50(46)59)58-45(61)34-63-43-25-18-13-19-26-43/h11-19,21-30,35-38,44,47-48,51H,20,32-34H2,1-10H3,(H,55,56,58,61)/t44-,47-,48-,51-,69?/m1/s1
Synonyms: 5'-MMT-2'-TBDMS A(Pac) 3'-CE phosphoramidite
N2-Isobutyryl-2'-tert-butyldimethylsilyl-7-deaza-5'-O-DMT-guanosine 3'-CE phosphoramidite
Description: N2-Isobutyryl-2'-tert-butyldimethylsilyl-7-deaza-5'-O-DMT-guanosine 3'-CE phosphoramidite is a specialized reagent used in oligonucleotide synthesis. It consists of a guanosine nucleoside modified at the N2 position with an isobutyryl group, at the 2' position with a tert-butyldimethylsilyl group, and at the 5' position with a DMT (dimethoxytrityl) group. Additionally, it contains a CE (2-cyanoethyl) phosphoramidite moiety, which serves as a protecting group during the synthesis process. This phosphoramidite derivative enables the efficient and selective incorporation of the modified guanosine into the growing nucleotide chain during solid-phase synthesis. It is crucial in the design and synthesis of modified oligonucleotides for various applications in molecular biology, genetics, diagnostics, and therapeutics.
CAT: BRP-01326
CAS: 1220889-83-7
MF: C51H69N6O9PSi
MF: 969.19
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InChIKey: ONYAZCDFEDIGRJ-DGMLWHETSA-N
CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=CC=3C(=O)N=C(NC(=O)C(C)C)NC32)C1O[Si](C)(C)C(C)(C)C)COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C
IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2-isobutyramido-4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C51H69N6O9PSi/c1-33(2)46(58)54-49-53-45-41(47(59)55-49)28-30-56(45)48-44(66-68(12,13)50(7,8)9)43(65-67(63-31-17-29-52)57(34(3)4)35(5)6)42(64-48)32-62-51(36-18-15-14-16-19-36,37-20-24-39(60-10)25-21-37)38-22-26-40(61-11)27-23-38/h14-16,18-28,30,33-35,42-44,48H,17,31-32H2,1-13H3,(H2,53,54,55,58,59)/t42-,43-,44-,48-,67?/m1/s1
Synonyms: N-[7-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-O-[(1,1-dimethylethyl)dimethylsilyl]-β-D-ribofuranosyl]-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-2-yl]-2-methylpropanamide; 7-Deaza Guanosine CED phosphoramidite; 7-Deaza 2'-TDDMS Guanosine(iBu) 3'-CE phosphoramidite
8-Oxo-5'-DMT-2'-TBDMS Guanosine(iBu) 3'-CE Phosphoramidite
Description: 8-Oxo-2'-tBDSilyl Guanosine CED Phosphoramidite is a specialized reagent utilized in oligonucleotide synthesis. It comprises a guanosine nucleoside modified with an 8-oxo group at the 8-position of the purine ring, protected with a TBDMS (tert-butyldimethylsilyl) group at the 2'-position, and with an isobutyryl (n-iBu) group. Additionally, it contains a phosphoramidite moiety with a CE (cyanoethyl) group, serving as a protecting group during synthesis. This phosphoramidite derivative enables precise and efficient incorporation of the modified guanosine into the growing nucleotide chain during solid-phase synthesis. The presence of the 8-oxo modification is significant for investigating oxidative stress, DNA damage, and RNA modification processes.
CAT: BRP-01327
MF: C49H67N8O9PSi
MF: 971.16
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InChIKey: OUWOXJVBKDMSKC-NHXVREKOSA-N
IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2-(((dimethylamino)methylene)amino)-6,8-dioxo-1,6,7,8-tetrahydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
InChI: InChI=1S/C49H67N8O9PSi/c1-32(2)57(33(3)4)67(63-29-17-28-50)65-41-39(30-62-49(34-18-15-14-16-19-34,35-20-24-37(60-10)25-21-35)36-22-26-38(61-11)27-23-36)64-45(42(41)66-68(12,13)48(5,6)7)56-43-40(52-47(56)59)44(58)54-46(53-43)51-31-55(8)9/h14-16,18-27,31-33,39,41-42,45H,17,29-30H2,1-13H3,(H,52,59)(H,53,54,58)/t39-,41-,42-,45-,67?/m1/s1
Synonyms: 8-Oxo-2'-tBDSilyl Guanosine CED Phosphoramidite
Fmoc-Amino-DMT C-3 CED phosphoramidite
Description: Fmoc-Amino-DMT C-3 CED phosphoramidite is a specialized compound used in oligonucleotide synthesis. It features an Fmoc-protected amino group, a DMT group for 5' hydroxyl protection, and a C-3 spacer linked to a cyanoethyl diisopropyl (CED) phosphoramidite group. This compound enables the controlled addition of amino functionalities to oligonucleotides, facilitating further chemical modifications or conjugations for various research and diagnostic applications.
CAT: BRP-01334
CAS: 146918-92-5
MF: C48H54N3O7P
MF: 815.93
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InChIKey: JGNRMZONTWRREU-UHFFFAOYSA-N
CanonicalSMILES: N#CCCOP(OC(COC(C=1C=CC=CC1)(C2=CC=C(OC)C=C2)C3=CC=C(OC)C=C3)CNC(=O)OCC4C=5C=CC=CC5C=6C=CC=CC64)N(C(C)C)C(C)C
IUPAC Name: (9H-fluoren-9-yl)methyl (3-(bis(4-methoxyphenyl)(phenyl)methoxy)-2-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)propyl)carbamate
InChI: InChI=1S/C48H54N3O7P/c1-34(2)51(35(3)4)59(57-30-14-29-49)58-41(31-50-47(52)55-33-46-44-19-12-10-17-42(44)43-18-11-13-20-45(43)46)32-56-48(36-15-8-7-9-16-36,37-21-25-39(53-5)26-22-37)38-23-27-40(54-6)28-24-38/h7-13,15-28,34-35,41,46H,14,30-33H2,1-6H3,(H,50,52)
Synonyms: 5-Oxa-2,7-diaza-6-phosphanonanoic acid, 4-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-6-(2-cyanoethoxy)-8-methyl-7-(1-methylethyl)-, 9H-fluoren-9-ylmethyl ester; 5,7-Dioxa-2-aza-6-phosphanonanoic acid, 4-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-6-[bis(1-methylethyl)amino]-9-cyano-, 9H-fluoren-9-ylmethyl ester; 9H-Fluoren-9-ylmethyl 4-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-6-(2-cyanoethoxy)-8-methyl-7-(1-methylethyl)-5-oxa-2,7-diaza-6-phosphanonanoate
TFA-Amino C-4 CED phosphoramidite
Description: TFA-Amino C-4 CED phosphoramidite is a specialized compound used in oligonucleotide synthesis. It contains a trifluoroacetyl (TFA)-protected amino group, a C-4 spacer, and a cyanoethyl diisopropyl (CED) phosphoramidite group. This compound facilitates controlled addition of amino functionalities to oligonucleotides, enabling further chemical modifications or conjugations for various research and diagnostic applications.
CAT: BRP-01335
CAS: 936471-68-0
MF: C15H27F3N3O3P
MF: 385.26
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InChIKey: XYETVXUHNJIELA-UHFFFAOYSA-N
CanonicalSMILES: N#CCCOP(OCCCCNC(=O)C(F)(F)F)N(C(C)C)C(C)C
IUPAC Name: 2-cyanoethyl (4-(2,2,2-trifluoroacetamido)butyl) diisopropylphosphoramidite
InChI: InChI=1S/C15H27F3N3O3P/c1-12(2)21(13(3)4)25(24-11-7-8-19)23-10-6-5-9-20-14(22)15(16,17)18/h12-13H,5-7,9-11H2,1-4H3,(H,20,22)
Synonyms: Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl 4-[(2,2,2-trifluoroacetyl)amino]butyl ester; 2-Cyanoethyl 4-[(2,2,2-trifluoroacetyl)amino]butyl N,N-bis(1-methylethyl)phosphoramidite
