Phosphoramidites - RNA / BOC Sciences

5-Propynyl-2'-O-Methyl Uridine CED phosphoramidite

Description: 5-Propynyl-2'-O-Methyl Uridine CED phosphoramidite is a specialized reagent used in oligonucleotide synthesis. It incorporates a modified form of uridine into nucleic acid sequences. This modification includes a propynyl group at the 5-position and an O-methyl group at the 2'-position of the ribose sugar. Additionally, it features a cyanoethyl (CED) protecting group, facilitating its incorporation into oligonucleotides during solid-phase synthesis. This reagent enables the synthesis of oligonucleotides with specific chemical modifications, suitable for various research and diagnostic applications in molecular biology and biotechnology.

CAT: BRP-01396

MF: C43H51N4O9P

MF: 798.86

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InChIKey: XOVYKNVGMJSHSM-DRQVPZTESA-N

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-5-(prop-1-yn-1-yl)-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C43H51N4O9P/c1-9-14-31-27-46(42(49)45-40(31)48)41-39(52-8)38(56-57(54-26-13-25-44)47(29(2)3)30(4)5)37(55-41)28-53-43(32-15-11-10-12-16-32,33-17-21-35(50-6)22-18-33)34-19-23-36(51-7)24-20-34/h10-12,15-24,27,29-30,37-39,41H,13,26,28H2,1-8H3,(H,45,48,49)/t37-,38-,39-,41-,57?/m1/s1

Synonyms: 5-Propynyl-2'-O-Methyl Uridine 3'-CE phosphoramidite

7-deaza-2'-O-Methyl Adenosine CED phosphoramidite

Description: 7-deaza-2'-O-Methyl Adenosine CED phosphoramidite is a specialized reagent used in oligonucleotide synthesis. It introduces a modified form of adenosine into nucleic acid sequences. This modification includes a 7-deaza substitution, where the nitrogen atom at the 7-position of the purine ring is replaced with a carbon atom, as well as an O-methyl group at the 2'-position of the ribose sugar. Additionally, it features a benzoyl (Bz) protecting group at the nucleobase and a cyanoethyl (CE) protecting group at the 3'-position, facilitating its incorporation into oligonucleotides during solid-phase synthesis. This reagent enables the synthesis of oligonucleotides with specific chemical modifications, suitable for various research and diagnostic applications in molecular biology and biotechnology.

CAT: BRP-01397

MF: C49H55N6O8P

MF: 886.97

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InChIKey: ILOKJXWUUOTGTB-SQPGCJOQSA-N

IUPAC Name: (2R,3R,4R,5R)-5-(4-benzamido-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C49H55N6O8P/c1-33(2)55(34(3)4)64(61-30-14-28-50)63-43-42(62-48(44(43)59-7)54-29-27-41-45(51-32-52-46(41)54)53-47(56)35-15-10-8-11-16-35)31-60-49(36-17-12-9-13-18-36,37-19-23-39(57-5)24-20-37)38-21-25-40(58-6)26-22-38/h8-13,15-27,29,32-34,42-44,48H,14,30-31H2,1-7H3,(H,51,52,53,56)/t42-,43-,44-,48-,64?/m1/s1

Synonyms: 7-deaza 2'-O-Methyl A(Bz) 3'-CE phosphoramidite

8-methyl-rGuanosine(n-ibu) 2'-TBDMS-3'-CE phosphoramidite

Description: 8-methyl-rGuanosine(n-ibu) 2'-TBDMS-3'-CE phosphoramidite is a modified nucleoside phosphoramidite with a tert-butyldimethylsilyl (TBDMS) protecting group on the 2' position and a 3'-CE protecting group. It contains an isobutyryl (n-ibu) group on the nitrogen atom of the guanine base at the 8 position. This phosphoramidite is commonly used in the synthesis of modified RNA molecules for research purposes.

CAT: BRP-01402

CAS: 634612-49-0

MF: C51H70N7O9PSi

MF: 984.20

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InChIKey: BVKTTXBRRDYOEU-MGIZDRFQSA-N

CanonicalSMILES: CC1=NC2=C(N1C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N(C(C)C)C(C)C)OCCC#N)O[Si](C)(C)C(C)(C)C)N=C(NC2=O)NC(=O)C(C)C

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]-8-methyl-6-oxo-1H-purin-2-yl]-2-methylpropanamide

InChI: InChI=1S/C51H70N7O9PSi/c1-32(2)46(59)55-49-54-45-42(47(60)56-49)53-35(7)57(45)48-44(67-69(13,14)50(8,9)10)43(66-68(64-30-18-29-52)58(33(3)4)34(5)6)41(65-48)31-63-51(36-19-16-15-17-20-36,37-21-25-39(61-11)26-22-37)38-23-27-40(62-12)28-24-38/h15-17,19-28,32-34,41,43-44,48H,18,30-31H2,1-14H3,(H2,54,55,56,59,60)/t41-,43-,44-,48-,68?/m1/s1

Synonyms: Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-8-methyl-N-(2-methyl-1-oxopropyl)-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; 8-methyl-2'-TBDMS-G(iBu)-3'-CE phosphoramidite

2'-tBDSilyl 2-Amino Purine Ribosine (n,n-dmf) 3'-CE phosphoramidite

Description: 2'-tBDSilyl 2-Amino Purine Ribosine (n,n-dmf) 3'-CE phosphoramidite is a modified nucleoside phosphoramidite used in solid-phase synthesis of nucleic acids. This compound is useful for the synthesis of modified nucleic acids with enhanced properties for various applications.

CAT: BRP-01404

CAS: 1643773-48-1

MF: C49H67N8O7PSi

MF: 939.17

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InChIKey: BJXKSHKSYZVPKC-WMHLWPNPSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C=NC(N=CN(C)C)=NC32)C1O[Si](C)(C)C(C)(C)C)COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2-(((dimethylamino)methylene)amino)-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C49H67N8O7PSi/c1-34(2)57(35(3)4)65(61-29-17-28-50)63-43-42(31-60-49(36-18-15-14-16-19-36,37-20-24-39(58-10)25-21-37)38-22-26-40(59-11)27-23-38)62-46(44(43)64-66(12,13)48(5,6)7)56-33-52-41-30-51-47(54-45(41)56)53-32-55(8)9/h14-16,18-27,30,32-35,42-44,46H,17,29,31H2,1-13H3/t42-,43-,44-,46-,65?/m1/s1

Synonyms: Methanimidamide, N'-[9-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-O-[(1,1-dimethylethyl)dimethylsilyl]-β-D-ribofuranosyl]-9H-purin-2-yl]-N,N-dimethyl-; N'-[9-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-O-[(1,1-dimethylethyl)dimethylsilyl]-β-D-ribofuranosyl]-9H-purin-2-yl]-N,N-dimethylmethanimidamide; 2'-tBDSilyl 2-Amino Purine Ribosine (n,n-dmf) CED OP

Adenosine-(N-Bz)-Methylene oxy-DMTr-Morpholino, cyanoethyl-N,N-diisopropyl diphosphoramidite

Description: Adenosine-(N-Bz)-Methylene oxy-DMTr-Morpholino, cyanoethyl-N,N-diisopropyl diphosphoramidite is a chemical compound used in the synthesis of nucleic acids. It is a modified nucleoside phosphoramidite, which is used in solid-phase synthesis of oligonucleotides. This compound contains a modified adenosine base, a morpholino group, a cyanoethyl group, and a diisopropyl phosphoramidite group, all of which play important roles in the synthesis of high-quality oligonucleotides. The presence of the N-Benzoyl (Bz) group protects the amine functionality of the adenosine base during synthesis, while the morpholino group is used to enhance the hybridization properties of the oligonucleotide. The cyanoethyl and diisopropyl groups are used as leaving groups during the coupling reactions in the solid-phase synthesis. Overall, this compound is an important building block in the synthesis of modified oligonucleotides for various applications in molecular biology and biotechnology.

CAT: BRP-01408

CAS: 2243974-80-1

MF: C47H53N8O6P

MF: 856.95

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InChIKey: ZRWXOZTUFQZCLQ-UHFFFAOYSA-N

CanonicalSMILES: N#CCCOP(N1CC(OC(COC(C=2C=CC=CC2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)C1)N5C=NC=6C(=NC=NC65)NC(=O)C=7C=CC=CC7)N(C(C)C)C(C)C

IUPAC Name: N-(9-((2R,6S)-6-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((2-cyanoethoxy)(diisopropylamino)phosphaneyl)morpholin-2-yl)-9H-purin-6-yl)benzamide

InChI: InChI=1S/C47H53N8O6P/c1-33(2)55(34(3)4)62(60-27-13-26-48)53-28-41(61-42(29-53)54-32-51-43-44(49-31-50-45(43)54)52-46(56)35-14-9-7-10-15-35)30-59-47(36-16-11-8-12-17-36,37-18-22-39(57-5)23-19-37)38-20-24-40(58-6)25-21-38/h7-12,14-25,31-34,41-42H,13,27-30H2,1-6H3,(H,49,50,52,56)

Cytidine-(N-Bz)-Methylene oxy-DMTr-Morpholino, cyanoethyl-N,N-diisopropyl diphosphoramidite

Description: Cytidine-(N-Bz)-Methylene oxy-DMTr-Morpholino, cyanoethyl-N,N-diisopropyl diphosphoramidite is a chemical compound used in the synthesis of nucleic acids, specifically in the process of solid-phase oligonucleotide synthesis. It is a modified cytidine residue with a benzoyl (Bz) protecting group on the amine group, a dimethoxytrityl (DMTr) protecting group on the hydroxyl group, and a morpholino group on the phosphate backbone. The cyanoethyl-N,N-diisopropyl diphosphoramidite is the phosphoramidite derivative used for coupling the cytidine residue to the growing oligonucleotide chain. This compound allows for efficient and selective incorporation of cytidine into the oligonucleotide sequence during synthesis.

CAT: BRP-01409

CAS: 2304678-30-4

MF: C46H53N6O7P

MF: 832.92

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InChIKey: SOMSQNICPOHJHU-UQSDLCBCSA-N

CanonicalSMILES: N#CCCOP(N1CC(OC(COC(C=2C=CC=CC2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)C1)N5C=CC(=NC5=O)NC(=O)C=6C=CC=CC6)N(C(C)C)C(C)C

IUPAC Name: N-(1-((2R,6S)-6-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((2-cyanoethoxy)(diisopropylamino)phosphaneyl)morpholin-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide

InChI: InChI=1S/C46H53N6O7P/c1-33(2)52(34(3)4)60(58-29-13-27-47)50-30-41(59-43(31-50)51-28-26-42(49-45(51)54)48-44(53)35-14-9-7-10-15-35)32-57-46(36-16-11-8-12-17-36,37-18-22-39(55-5)23-19-37)38-20-24-40(56-6)25-21-38/h7-12,14-26,28,33-34,41,43H,13,29-32H2,1-6H3,(H,48,49,53,54)/t41-,43+,60?/m0/s1

Synonyms: Phosphonamidous acid, P-[(2R,6S)-2-[4-(benzoylamino)-2-oxo-1(2H)-pyrimidinyl]-6-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-4-morpholinyl]-N,N-bis(1-methylethyl)-, 2-cyanoethyl ester

Guanosine-(N2-iBu)-Methylene oxy-DMTr-Morpholino, cyanoethyl-N,N-diisopropyl diphosphoramidite

Description: Guanosine-(N2-iBu)-Methylene oxy-DMTr-Morpholino, cyanoethyl-N,N-diisopropyl diphosphoramidite is a compound used in organic synthesis for the modification of nucleosides and nucleotides. It is a phosphoramidite derivative that can be used in the synthesis of modified RNA molecules for various research purposes. The compound contains a guanosine base modified at the N2 position with an isobutyl group, a methyleneoxy linker, a dimethoxytrityl (DMTr) protecting group, and a morpholino moiety. The cyanoethyl-N,N-diisopropyl diphosphoramidite group allows for efficient coupling reactions during RNA synthesis.

CAT: BRP-01410

CAS: 2243974-81-2

MF: C44H55N8O7P

MF: 838.93

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InChIKey: HQRPMELFURAQPY-VMZRNFFESA-N

CanonicalSMILES: N#CCCOP(N1CC(OC(COC(C=2C=CC=CC2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)C1)N5C=NC=6C(=O)N=C(NC(=O)C(C)C)NC65)N(C(C)C)C(C)C

IUPAC Name: N-(9-((2R,6S)-6-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((2-cyanoethoxy)(diisopropylamino)phosphaneyl)morpholin-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide

InChI: InChI=1S/C44H55N8O7P/c1-29(2)41(53)48-43-47-40-39(42(54)49-43)46-28-51(40)38-26-50(60(58-24-12-23-45)52(30(3)4)31(5)6)25-37(59-38)27-57-44(32-13-10-9-11-14-32,33-15-19-35(55-7)20-16-33)34-17-21-36(56-8)22-18-34/h9-11,13-22,28-31,37-38H,12,24-27H2,1-8H3,(H2,47,48,49,53,54)/t37-,38+,60?/m0/s1

N3-Thiobenzoylethyl 2'-TBDMS Uridine 3'-CE phosphoramidite

Description: N3-Thiobenzoylethyl Uridine CED phosphoramidite is a compound used in oligonucleotide synthesis. It features uridine with a 2'-tert-butyldimethylsilyl (TBDMS) group, protecting the 2'-hydroxyl group, and a N3-thiobenzoylethyl group at the nitrogen atom of the uracil ring. Additionally, it includes a cyanoethyl (CE) group at the 3'-position and is attached to a phosphoramidite moiety for solid-phase synthesis. This compound facilitates the controlled synthesis of modified oligonucleotides, enabling precise chemical modifications and enhancing stability.

CAT: BRP-01413

MF: C54H69N4O10PSSi

MF: 1025.27

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InChIKey: QVVPMOVSGPVKRC-IHMJTFHYSA-N

IUPAC Name: S-(2-(3-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)tetrahydrofuran-2-yl)-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)ethyl) benzothioate

InChI: InChI=1S/C54H69N4O10PSSi/c1-38(2)58(39(3)4)69(65-35-18-32-55)67-48-46(37-64-54(41-21-16-13-17-22-41,42-23-27-44(62-8)28-24-42)43-25-29-45(63-9)30-26-43)66-50(49(48)68-71(10,11)53(5,6)7)57-33-31-47(59)56(52(57)61)34-36-70-51(60)40-19-14-12-15-20-40/h12-17,19-31,33,38-39,46,48-50H,18,34-37H2,1-11H3/t46-,48-,49-,50-,69?/m1/s1

Synonyms: N3-Thiobenzoylethyl Uridine CED phosphoramidite

N6-Benzyl 2'-TBDMS Adenosine CED phosphoramidite

Description: N6-Benzyl 2'-TBDMS Adenosine CED phosphoramidite is used in the solid-phase synthesis of RNA molecules. The N6-benzyl and 2'-TBDMS (tert-butyldimethylsilyl) protecting groups are commonly used to protect specific functional groups on the nucleoside, allowing for selective deprotection and further modification during the synthesis process. The CED (cyclohexyl-N,N-diisopropylaminoethyl) group is a phosphoramidite moiety used to facilitate the attachment of the nucleoside to the solid support during synthesis. This modified phosphoramidite is widely used in the field of nucleic acid chemistry for the synthesis of RNA molecules with specific modifications at the adenosine nucleoside position.

CAT: BRP-01414

MF: C53H68N7O7PSi

MF: 974.21

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InChIKey: GZBJCGYSXUSQQJ-MGEVAVFRSA-N

IUPAC Name: (2R,3R,4R,5R)-5-(6-(benzylamino)-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C53H68N7O7PSi/c1-37(2)60(38(3)4)68(64-32-18-31-54)66-47-45(34-63-53(40-21-16-13-17-22-40,41-23-27-43(61-8)28-24-41)42-25-29-44(62-9)30-26-42)65-51(48(47)67-69(10,11)52(5,6)7)59-36-58-46-49(56-35-57-50(46)59)55-33-39-19-14-12-15-20-39/h12-17,19-30,35-38,45,47-48,51H,18,32-34H2,1-11H3,(H,55,56,57)/t45-,47-,48-,51-,68?/m1/s1

Synonyms: Adenosine, N-Benzyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; 2'-TBDMS A(Bn) 3'-CE phosphoramidite; N6-Benzyl Adenosine CED phosphoramidite

N6-Isopentenyl 2'-TBDMS Adenosine CED phosphoramidite

Description: N6-Isopentenyl 2'-TBDMS Adenosine CED phosphoramidite is a reagent used in solid-phase synthesis of oligonucleotides. It contains a modified adenosine nucleoside with a TBDMS (tert-butyldimethylsilyl) group at the 2'-position and a CED (2-cyanoethyl-N,N-diisopropyl) phosphoramidite group at the N6-position. This phosphoramidite derivative allows for efficient and selective coupling reactions during the synthesis of modified oligonucleotides.

CAT: BRP-01416

MF: C51H70N7O7PSi

MF: 952.20

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InChIKey: WCJAFYSVXPNXPT-VVPIBMPJSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(6-((3-methylbut-2-en-1-yl)amino)-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C51H70N7O7PSi/c1-35(2)28-30-53-47-44-48(55-33-54-47)57(34-56-44)49-46(65-67(12,13)50(7,8)9)45(64-66(62-31-17-29-52)58(36(3)4)37(5)6)43(63-49)32-61-51(38-18-15-14-16-19-38,39-20-24-41(59-10)25-21-39)40-22-26-42(60-11)27-23-40/h14-16,18-28,33-34,36-37,43,45-46,49H,17,30-32H2,1-13H3,(H,53,54,55)/t43-,45-,46-,49-,66?/m1/s1

Synonyms: N6-Isopentenyl Adenosine CED phosphoramidite; N6-Isopentenyl 2'-TBDMS rA 3'-CE phosphoramidite

2'-O-PivOM-5'-O-DMT-Guanosine (N-ipr-PAC) 3'-CEP

Description: 2'-O-PivOM-5'-O-DMT-Guanosine (N-ipr-PAC) 3'-CEP is a specialized nucleotide used in the synthesis of modified oligonucleotides. It features protective groups for the 2'- and 5'-hydroxyls, the N2 amino group, and the 3'-hydroxyl, facilitating the stepwise addition of nucleotides during solid-phase synthesis. This compound is crucial for creating RNA and DNA molecules with enhanced stability and functionality, making it valuable in biochemical and medical research.

CAT: BRP-01423

CAS: 1792219-30-7

MF: C57H70N7O12P

MF: 1076.18

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InChIKey: NPTZAQHIJAFZFD-AGVGNCMWSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C(=O)N=C(NC(=O)COC4=CC=C(C=C4)C(C)C)NC32)C1OCOC(=O)C(C)(C)C)COC(C=5C=CC=CC5)(C6=CC=C(OC)C=C6)C7=CC=C(OC)C=C7)N(C(C)C)C(C)C

IUPAC Name: (((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-2-(2-(2-(4-isopropylphenoxy)acetamido)-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl)oxy)methyl pivalate

InChI: InChI=1S/C57H70N7O12P/c1-36(2)39-18-24-45(25-19-39)70-33-47(65)60-55-61-51-48(52(66)62-55)59-34-63(51)53-50(71-35-72-54(67)56(7,8)9)49(76-77(74-31-15-30-58)64(37(3)4)38(5)6)46(75-53)32-73-57(40-16-13-12-14-17-40,41-20-26-43(68-10)27-21-41)42-22-28-44(69-11)29-23-42/h12-14,16-29,34,36-38,46,49-50,53H,15,31-33,35H2,1-11H3,(H2,60,61,62,65,66)/t46-,49-,50-,53-,77?/m1/s1

Synonyms: 2'-OPivOM G(ipr-pac) amidite; Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(2,2-dimethyl-1-oxopropoxy)methyl]-N-[2-[4-(1-methylethyl)phenoxy]acetyl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; 2'-O-PivOM-5'-O-DMT-Guanosine (N-ipr-PAC) 3'-CE phosphoramidite

MMT-2'-tBDSilyl Adenosine (n-PAC) methyl phosphoramidite

Description: MMT-2'-tBDSilyl Adenosine (n-PAC) methyl phosphoramidite is a reagent used in oligonucleotide synthesis. It comprises adenosine with a monomethoxytrityl (MMT) protecting group at the 2'-position and a tert-butyldimethylsilyl (tBDSilyl) group at the 3'-position. Additionally, the amino group is protected by a phenoxyacetyl (PAC) group. This compound facilitates the controlled synthesis of modified oligonucleotides with enhanced stability and precise chemical modifications.

CAT: BRP-01424

MF: C51H65N6O8PSi

MF: 949.16

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Inquiry

InChIKey: SRIPSWWUYSURFE-ZPKZLDMBSA-N

CanonicalSMILES: O=C(NC1=NC=NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C=5C=CC=CC5)C6=CC=C(OC)C=C6)C(OP(OC)N(C(C)C)C(C)C)C3O[Si](C)(C)C(C)(C)C)COC=7C=CC=CC7

IUPAC Name: (2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-2-(((4-methoxyphenyl)diphenylmethoxy)methyl)-5-(6-(2-phenoxyacetamido)-9H-purin-9-yl)tetrahydrofuran-3-yl methyl diisopropylphosphoramidite

InChI: InChI=1S/C51H65N6O8PSi/c1-35(2)57(36(3)4)66(60-9)64-45-42(31-62-51(37-21-15-12-16-22-37,38-23-17-13-18-24-38)39-27-29-40(59-8)30-28-39)63-49(46(45)65-67(10,11)50(5,6)7)56-34-54-44-47(52-33-53-48(44)56)55-43(58)32-61-41-25-19-14-20-26-41/h12-30,33-36,42,45-46,49H,31-32H2,1-11H3,(H,52,53,55,58)/t42-,45-,46-,49-,66?/m1/s1

Synonyms: 5'-O-MMTr-2'-OTBS A(Pac) OMe-amidite; 5'-O-MMTr-2'-O-TBDMS-A(Pac)-3'-Methoxy-phosphoramidite; Adenosine, 2'-O-[(1,1-dimethylethyl)dimethylsilyl]-5'-O-[(4-methoxyphenyl)diphenylmethyl]-N-(phenoxyacetyl)-, 3'-[methyl bis(1-methylethyl)phosphoramidite]

MMT-2'-tBDSilyl Guanosine (n-PAC) methyl phosphoramidite

Description: MMT-2'-tBDSilyl Guanosine (n-PAC) methyl phosphoramidite is a reagent used in oligonucleotide synthesis. It consists of guanosine with a monomethoxytrityl (MMT) group protecting the 2'-position, a tert-butyldimethylsilyl (tBDSilyl) group protecting the 3'-position, and a phenoxyacetyl (PAC) group protecting the amino group. Additionally, it includes a methyl phosphoramidite moiety. This compound facilitates the controlled synthesis of modified oligonucleotides, providing increased stability and precise chemical modifications.

CAT: BRP-01425

MF: C51H65N6O9PSi

MF: 965.16

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Inquiry

InChIKey: KJVBHYXASYADQV-YPSZUEOQSA-N

IUPAC Name: (2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-2-(((4-methoxyphenyl)diphenylmethoxy)methyl)-5-(6-oxo-2-(2-phenoxyacetamido)-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl methyl diisopropylphosphoramidite

InChI: InChI=1S/C51H65N6O9PSi/c1-34(2)57(35(3)4)67(61-9)65-44-41(31-63-51(36-21-15-12-16-22-36,37-23-17-13-18-24-37)38-27-29-39(60-8)30-28-38)64-48(45(44)66-68(10,11)50(5,6)7)56-33-52-43-46(56)54-49(55-47(43)59)53-42(58)32-62-40-25-19-14-20-26-40/h12-30,33-35,41,44-45,48H,31-32H2,1-11H3,(H2,53,54,55,58,59)/t41-,44-,45-,48-,67?/m1/s1

Synonyms: 5'-O-MMTr-2'-OTBS G(Pac) OMe-amidite; 5'-O-MMTr-2'-O-TBDMS-G(Pac)-3'-Methoxy-phosphoramidite

2'-tBDSilyl Adenosine (n-PAC) methyl phosphoramidite

Description: 5'-O-DMTr-2'-O-TBDMS-A(Pac)-3'-Methoxy-phosphoramidite is a reagent used in oligonucleotide synthesis. It includes adenosine with a dimethoxytrityl (DMTr) group at the 5'-position, a tert-butyldimethylsilyl (TBDMS) group at the 2'-position, a phenoxyacetyl (Pac) protecting group on the amino group, and a methoxy phosphoramidite at the 3'-position. This configuration enhances stability and allows precise incorporation of adenosine into synthetic oligonucleotides.

CAT: BRP-01426

MF: C52H67N6O9PSi

MF: 979.18

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Inquiry

InChIKey: PVCNWLDGLBVZQK-KJMRTUCVSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(6-(2-phenoxyacetamido)-9H-purin-9-yl)tetrahydrofuran-3-yl methyl diisopropylphosphoramidite

InChI: InChI=1S/C52H67N6O9PSi/c1-35(2)58(36(3)4)68(62-10)66-46-43(31-64-52(37-19-15-13-16-20-37,38-23-27-40(60-8)28-24-38)39-25-29-41(61-9)30-26-39)65-50(47(46)67-69(11,12)51(5,6)7)57-34-55-45-48(53-33-54-49(45)57)56-44(59)32-63-42-21-17-14-18-22-42/h13-30,33-36,43,46-47,50H,31-32H2,1-12H3,(H,53,54,56,59)/t43-,46-,47-,50-,68?/m1/s1

Synonyms: 2'-OTBS A(Pac) OMe-amidite; 5'-O-DMTr-2'-O-TBDMS-A(Pac)-3'-Methoxy-phosphoramidite

2'-tBDSilyl Cytidine (n-PAC) methyl phosphoramidite

Description: 2'-tBDSilyl Cytidine (n-PAC) methyl phosphoramidite is a key reagent used in oligonucleotide synthesis. It consists of cytidine with a tert-butyldimethylsilyl (tBDSilyl) group protecting the 2'-position and a phenoxyacetyl (PAC) group guarding the amino group. Additionally, it contains a methyl phosphoramidite moiety. This compound facilitates the controlled synthesis of modified oligonucleotides, providing enhanced stability and enabling precise chemical modifications.

CAT: BRP-01427

MF: C51H67N4O10PSi

MF: 955.16

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Inquiry

InChIKey: AJLSWJSVOOCSFR-VUQXMIQESA-N

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2-oxo-4-(2-phenoxyacetamido)pyrimidin-1(2H)-yl)tetrahydrofuran-3-yl methyl diisopropylphosphoramidite

InChI: InChI=1S/C51H67N4O10PSi/c1-35(2)55(36(3)4)66(60-10)64-46-43(33-62-51(37-19-15-13-16-20-37,38-23-27-40(58-8)28-24-38)39-25-29-41(59-9)30-26-39)63-48(47(46)65-67(11,12)50(5,6)7)54-32-31-44(53-49(54)57)52-45(56)34-61-42-21-17-14-18-22-42/h13-32,35-36,43,46-48H,33-34H2,1-12H3,(H,52,53,56,57)/t43-,46-,47-,48-,66?/m1/s1

Synonyms: 5'-O-DMTr-2'-OTBS C(Pac) OMe-amidite; 5'-O-DMTr-2'-O-TBDMS-C(Pac)-3'-Methoxy-phosphoramidite

2'-tBDSilyl Guanosine (n-PAC) methyl phosphoramidite

Description: 2'-tBDSilyl Guanosine (n-PAC) methyl phosphoramidite is a reagent commonly used in oligonucleotide synthesis. It consists of guanosine with a tert-butyldimethylsilyl (tBDSilyl) group protecting the 2'-position and a phenoxyacetyl (PAC) group protecting the amino group. Additionally, it features a methyl phosphoramidite moiety. This compound facilitates the controlled synthesis of modified oligonucleotides, providing increased stability and precise chemical modifications.

CAT: BRP-01428

MF: C52H67N6O10PSi

MF: 995.18

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Inquiry

InChIKey: CEBBQJQCBLOLKE-XIZLBUQOSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(6-oxo-2-(2-phenoxyacetamido)-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl methyl diisopropylphosphoramidite

InChI: InChI=1S/C52H67N6O10PSi/c1-34(2)58(35(3)4)69(63-10)67-45-42(31-65-52(36-19-15-13-16-20-36,37-23-27-39(61-8)28-24-37)38-25-29-40(62-9)30-26-38)66-49(46(45)68-70(11,12)51(5,6)7)57-33-53-44-47(57)55-50(56-48(44)60)54-43(59)32-64-41-21-17-14-18-22-41/h13-30,33-35,42,45-46,49H,31-32H2,1-12H3,(H2,54,55,56,59,60)/t42-,45-,46-,49-,69?/m1/s1

Synonyms: 5'-O-DMTr-2'-OTBS G(Pac) OMe-amidite; 5'-O-DMTr-2'-O-TBDMS-G(Pac)-3'-Methoxy-phosphoramidite

2'-tBDSilyl Cytidine (n-bz) methyl phosphoramidite

Description: 2'-tBDSilyl Cytidine (n-bz) methyl phosphoramidite is a crucial component in the synthesis of modified oligonucleotides. This compound consists of cytidine with a tert-butyldimethylsilyl (tBDSilyl) group protecting the 2'-position and a benzoyl (n-bz) group guarding the amino group. Additionally, it includes a methyl phosphoramidite moiety. This reagent enables controlled oligonucleotide synthesis, allowing for precise chemical modifications and enhancing the stability of the resulting oligonucleotide strands.

CAT: BRP-01429

CAS: 118684-40-5

MF: C50H65N4O9PSi

MF: 925.15

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Inquiry

InChIKey: AJJZVDGKUIEJGA-LORUJQNASA-N

CanonicalSMILES: O=C1N=C(C=CN1C2OC(COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)C(OP(OC)N(C(C)C)C(C)C)C2O[Si](C)(C)C(C)(C)C)NC(=O)C=6C=CC=CC6

IUPAC Name: (2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl methyl diisopropylphosphoramidite

InChI: InChI=1S/C50H65N4O9PSi/c1-34(2)54(35(3)4)64(59-10)62-44-42(33-60-50(37-21-17-14-18-22-37,38-23-27-40(57-8)28-24-38)39-25-29-41(58-9)30-26-39)61-47(45(44)63-65(11,12)49(5,6)7)53-32-31-43(52-48(53)56)51-46(55)36-19-15-13-16-20-36/h13-32,34-35,42,44-45,47H,33H2,1-12H3,(H,51,52,55,56)/t42-,44-,45-,47-,64?/m1/s1

Synonyms: 5'-O-DMTr-2'-OTBS C(Bz) OMe-amidite; 5'-O-DMTr-2'-O-TBDMS-C(Bz)-3'-Methoxy-phosphoramidite; Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-[methyl bis(1-methylethyl)phosphoramidite]

MMT-2'-tBDSilyl Adenosine (n-bz) methyl phosphoramidite

Description: MMT-2'-tBDSilyl Adenosine (n-bz) methyl phosphoramidite is a reagent utilized in oligonucleotide synthesis. It consists of adenosine with a monomethoxytrityl (MMT) protecting group at the 2'-position and a tert-butyldimethylsilyl (tBDSilyl) group at the 3'-position. The amino group is safeguarded by a benzoyl (bz) group. This compound is employed to synthesize modified oligonucleotides with increased stability and precise chemical modifications.

CAT: BRP-01430

CAS: 101904-21-6

MF: C50H63N6O7PSi

MF: 919.15

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Inquiry

InChIKey: NUQPPYCKFPVDHB-HHRUMCNBSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OC)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=C(C=C7)OC

IUPAC Name: N-[9-[(2R,3R,4R,5R)-3-[tert-butyl(dimethyl)silyl]oxy-4-[[di(propan-2-yl)amino]-methoxyphosphanyl]oxy-5-[[(4-methoxyphenyl)-diphenylmethoxy]methyl]oxolan-2-yl]purin-6-yl]benzamide

InChI: InChI=1S/C50H63N6O7PSi/c1-34(2)56(35(3)4)64(59-9)62-43-41(31-60-50(37-23-17-13-18-24-37,38-25-19-14-20-26-38)39-27-29-40(58-8)30-28-39)61-48(44(43)63-65(10,11)49(5,6)7)55-33-53-42-45(51-32-52-46(42)55)54-47(57)36-21-15-12-16-22-36/h12-30,32-35,41,43-44,48H,31H2,1-11H3,(H,51,52,54,57)/t41-,43-,44-,48-,64?/m1/s1

Synonyms: Adenosine, N-benzoyl-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-5'-O-[(4-methoxyphenyl)diphenylmethyl]-, 3'-[methyl bis(1-methylethyl)phosphoramidite]; 5'-O-MMTr-2'-OTBS A(Bz) OMe-amidite; 5'-O-MMTr-2'-O-TBDMS-A(Bz)-3'-Methoxy-phosphoramidite

MMT-2'-tBDSilyl Guanosine (n-ibu) methyl phosphoramidite

Description: MMT-2'-tBDSilyl Guanosine (n-ibu) methyl phosphoramidite is a reagent commonly used in oligonucleotide synthesis. It consists of guanosine with a monomethoxytrityl (MMT) group protecting the 2'-position, a tert-butyldimethylsilyl (tBDSilyl) group protecting the 3'-position, and an isobutyryl (n-ibu) group protecting the amino group. This compound enables the controlled synthesis of modified oligonucleotides, providing increased stability and precise chemical modifications.

CAT: BRP-01431

MF: C47H65N6O8PSi

MF: 901.13

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Inquiry

InChIKey: WRCLQRTWWDMGKQ-DMWBDYODSA-N

IUPAC Name: (2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-(((4-methoxyphenyl)diphenylmethoxy)methyl)tetrahydrofuran-3-yl methyl diisopropylphosphoramidite

InChI: InChI=1S/C47H65N6O8PSi/c1-30(2)42(54)50-45-49-41-38(43(55)51-45)48-29-52(41)44-40(61-63(12,13)46(7,8)9)39(60-62(57-11)53(31(3)4)32(5)6)37(59-44)28-58-47(33-20-16-14-17-21-33,34-22-18-15-19-23-34)35-24-26-36(56-10)27-25-35/h14-27,29-32,37,39-40,44H,28H2,1-13H3,(H2,49,50,51,54,55)/t37-,39-,40-,44-,62?/m1/s1

Synonyms: 5'-O-MMTr-2'-OTBS G(iBu) OMe-amidite; 5'-O-MMTr-2'-O-TBDMS-G(iBu)-3'-Methoxy-phosphoramidite

Psoralen 18-Atom Spacer CED phosphoramidite

Description: The Psoralen 18-Atom Spacer CED phosphoramidite is a specialized compound used in nucleic acid synthesis. It combines the photoreactive properties of psoralen with an 18-atom spacer and a CED phosphoramidite group. This enables controlled modification of nucleic acids, allowing for the introduction of psoralen moieties at specific positions within DNA or RNA strands. These modifications can then be crosslinked under ultraviolet (UV) light, making this compound valuable in various molecular biology applications, including DNA-protein interaction studies and nucleic acid structure mapping.

CAT: BRP-01437

MF: C36H55N2O11P

MF: 722.80

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Inquiry

InChIKey: VDDDZCZDLKUGAG-UHFFFAOYSA-N

CanonicalSMILES: N#CCCOP(OCCOCCOCCOCCOCCOCCOCC1=C(OC2=C1C=C(C(C)=C3)C(OC3=O)=C2C)C)N(C(C)C)C(C)C

IUPAC Name: 2-cyanoethyl (1-(2,5,9-trimethyl-7-oxo-7H-furo[3,2-g]chromen-3-yl)-2,5,8,11,14,17-hexaoxanonadecan-19-yl) diisopropylphosphoramidite

InChI: InChI=1S/C36H55N2O11P/c1-26(2)38(27(3)4)50(46-10-8-9-37)47-22-21-44-18-17-42-14-13-40-11-12-41-15-16-43-19-20-45-25-33-30(7)48-36-29(6)35-31(24-32(33)36)28(5)23-34(39)49-35/h23-24,26-27H,8,10-22,25H2,1-7H3