Phosphoramidites

Beta-L-2'-tBDSilyl Cytidine (n-bz) 3'-CED phosphoramidite

Description: Beta-L-2'-tBDSilyl Cytidine (n-bz) 3'-CED phosphoramidite is a specialized reagent used in oligonucleotide synthesis. It incorporates modified cytidine into nucleic acid sequences with a beta-L configuration at the 2'-position of the ribose sugar, a benzoyl protecting group (n-bz) on the cytidine base, and a cyanoethyl (CED) protecting group at the 3'-position. This reagent facilitates precise and controlled synthesis of oligonucleotides for various research and therapeutic applications in molecular biology.

CAT: BRP-01382

Molecular Formula: C52H66N5O9PSi

Molecular Weight: 964.17

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InChIKey: VWNXEDLLHIFAOL-KEDRMCAUSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=CC(=NC2=O)NC(=O)C=3C=CC=CC3)C1O[Si](C)(C)C(C)(C)C)COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C

IUPAC Name: (2S,3S,4S,5S)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C52H66N5O9PSi/c1-36(2)57(37(3)4)67(63-34-18-32-53)65-46-44(35-62-52(39-21-16-13-17-22-39,40-23-27-42(60-8)28-24-40)41-25-29-43(61-9)30-26-41)64-49(47(46)66-68(10,11)51(5,6)7)56-33-31-45(55-50(56)59)54-48(58)38-19-14-12-15-20-38/h12-17,19-31,33,36-37,44,46-47,49H,18,34-35H2,1-11H3,(H,54,55,58,59)/t44-,46-,47-,49-,67?/m0/s1

Synonyms: Beta-L-2'-TBDMS C(Bz) 3'-CE phosphoramidite; β-L-Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-tert-butyldimethylsilyl)-β-L-cytidine 3'-O-[O-(2-cyanoethyl)-N,N'-diisopropylphosphoramidite]

5-Iodo Uridine 2'-O-Methyl CED phosphoramidite

Description: 5-Iodo Uridine 2'-O-Methyl CED phosphoramidite is a specialized reagent used in oligonucleotide synthesis to introduce a modified form of uridine into nucleic acid sequences. This modification includes an iodine atom at the 5-position of the uracil base and an O-methyl group at the 2'-position of the ribose sugar. Additionally, it features a cyanoethyl (CED) protecting group, facilitating its incorporation into oligonucleotides during solid-phase synthesis. This reagent allows for the synthesis of oligonucleotides with specific chemical modifications, suitable for various research and diagnostic applications in molecular biology and biotechnology.

CAT: BRP-01386

CAS: 2382941-85-5

Molecular Formula: C40H48IN4O9P

Molecular Weight: 886.71

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InChIKey: HKRBVLVOTKMIQV-NITXCQAWSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OC)N2C=C(C(=O)NC2=O)I)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(5-iodo-2,4-dioxopyrimidin-1-yl)-4-methoxyoxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C40H48IN4O9P/c1-26(2)45(27(3)4)55(52-23-11-22-42)54-35-34(53-38(36(35)50-7)44-24-33(41)37(46)43-39(44)47)25-51-40(28-12-9-8-10-13-28,29-14-18-31(48-5)19-15-29)30-16-20-32(49-6)21-17-30/h8-10,12-21,24,26-27,34-36,38H,11,23,25H2,1-7H3,(H,43,46,47)/t34-,35-,36-,38-,55?/m1/s1

Synonyms: 5'-O-DMTr-2'-O-methyl-5-iodouridine-3'-CEN-phosphoramidite; 2'-O-Me-5-I-U-3'-phosphoramidite; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-5-iodo-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

Amino Modifier 2'-O-Methyl C(dmf) 3'-CE phosphoramidite

Description: Amino Modifier 2'-O-Methyl Cytidine CED phosphoramidite is a specialized reagent used in oligonucleotide synthesis to introduce a modification at the 2'-position of the ribose sugar of cytidine. Additionally, it features a dimethylformamide (DMF) protecting group on the amino modification and a cyanoethyl (CE) protecting group at the 3'-position, facilitating its incorporation into oligonucleotides during solid-phase synthesis. This reagent allows for the synthesis of oligonucleotides with specific chemical modifications, suitable for various research and diagnostic applications in molecular biology and biotechnology.

CAT: BRP-01387

Molecular Formula: C54H70F3N8O10P

Molecular Weight: 1079.17

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InChIKey: VSEXZAHMBUUFKH-GRFNBCEFSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(4-(((dimethylamino)methylene)amino)-2-oxo-5-((E)-3-oxo-3-((6-(2,2,2-trifluoroacetamido)hexyl)amino)prop-1-en-1-yl)pyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C54H70F3N8O10P/c1-37(2)65(38(3)4)76(73-33-17-30-58)75-47-45(35-72-53(40-18-13-12-14-19-40,41-21-25-43(69-7)26-22-41)42-23-27-44(70-8)28-24-42)74-50(48(47)71-9)64-34-39(49(62-52(64)68)61-36-63(5)6)20-29-46(66)59-31-15-10-11-16-32-60-51(67)54(55,56)57/h12-14,18-29,34,36-38,45,47-48,50H,10-11,15-17,31-33,35H2,1-9H3,(H,59,66)(H,60,67)/b29-20+,61-36?/t45-,47-,48-,50-,76?/m1/s1

Synonyms: Amino Modifier 2'-O-Methyl Cytidine CED phosphoramidite

5-Propynyl-2'-O-Methyl Cytidine CED phosphoramidite

Description: 5-Propynyl-2'-O-Methyl Cytidine CED phosphoramidite is a specialized reagent used in oligonucleotide synthesis to introduce a modified form of cytidine into nucleic acid sequences. This modification involves adding a propynyl group at the 5-position and a benzoyl (Bz) protecting group at the nucleobase of the cytidine nucleoside. Additionally, it features a cyanoethyl (CE) protecting group at the 3'-position, facilitating its incorporation into oligonucleotides during solid-phase synthesis. This reagent enables the synthesis of oligonucleotides with specific chemical modifications, suitable for various research and diagnostic applications in molecular biology and biotechnology.

CAT: BRP-01388

Molecular Formula: C50H56N5O9P

Molecular Weight: 901.98

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InChIKey: NCBCXPSFMVIXKS-BRQQSDFOSA-N

IUPAC Name: (2R,3R,4R,5R)-5-(4-benzamido-2-oxo-5-(prop-1-yn-1-yl)pyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C50H56N5O9P/c1-9-17-37-32-54(49(57)53-46(37)52-47(56)36-18-12-10-13-19-36)48-45(60-8)44(64-65(62-31-16-30-51)55(34(2)3)35(4)5)43(63-48)33-61-50(38-20-14-11-15-21-38,39-22-26-41(58-6)27-23-39)40-24-28-42(59-7)29-25-40/h10-15,18-29,32,34-35,43-45,48H,16,31,33H2,1-8H3,(H,52,53,56,57)/t43-,44-,45-,48-,65?/m1/s1

Synonyms: 5-Propynyl-2'-O-Me C(Bz) 3'-CE phosphoramidite; Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-5-(1-propynyl)-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

7-Iodo 7-deaza 2'-O-Methyl Adenosine CED phosphoramidite

Description: 7-Iodo 7-deaza 2'-O-Methyl Adenosine CED phosphoramidite is a specialized reagent used in oligonucleotide synthesis to introduce a modified form of adenosine into nucleic acid sequences. This modification includes replacing the nitrogen atom at the 7-position of the purine ring with an iodine atom, creating a 7-iodo 7-deaza adenosine. Additionally, it features an O-methyl group at the 2'-position of the ribose sugar and a benzoyl (Bz) protecting group at the nucleobase. Furthermore, it includes a cyanoethyl (CE) protecting group at the 3'-position, facilitating its incorporation into oligonucleotides during solid-phase synthesis. This reagent enables the synthesis of oligonucleotides with specific chemical modifications, suitable for various research and diagnostic applications in molecular biology and biotechnology.

CAT: BRP-01389

Molecular Formula: C49H54IN6O8P

Molecular Weight: 1012.87

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InChIKey: QZLOROSWVDZRAP-FVPMUMJWSA-N

IUPAC Name: (2R,3R,4R,5R)-5-(4-benzamido-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C49H54IN6O8P/c1-32(2)56(33(3)4)65(62-28-14-27-51)64-43-41(30-61-49(35-17-12-9-13-18-35,36-19-23-38(58-5)24-20-36)37-21-25-39(59-6)26-22-37)63-48(44(43)60-7)55-29-40(50)42-45(52-31-53-46(42)55)54-47(57)34-15-10-8-11-16-34/h8-13,15-26,29,31-33,41,43-44,48H,14,28,30H2,1-7H3,(H,52,53,54,57)/t41-,43-,44-,48-,65?/m1/s1

Synonyms: 7-Iodo 7-deaza 2'-O-Methyl A(Bz) 3'-CE phosphoramidite

7-Iodo 7-deaza 2'-O-Methyl Guanosine CED phosphoramidite

Description: 7-Iodo 7-deaza 2'-O-Methyl Guanosine CED phosphoramidite is a specialized reagent employed in oligonucleotide synthesis for introducing a modified form of guanosine into nucleic acid sequences. It incorporates a 7-iodo modification on the guanine base, a 7-deaza modification to replace the nitrogen atom at the 7-position of the purine ring, an O-methyl group at the 2'-position of the ribose sugar, an isobutyryl protecting group on the guanosine base, and a cyanoethyl protecting group at the 3'-position. This reagent facilitates the controlled synthesis of oligonucleotides with specific chemical modifications, suitable for various research and diagnostic applications in molecular biology and biotechnology.

CAT: BRP-01390

Molecular Formula: C46H56IN6O9P

Molecular Weight: 994.85

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InChIKey: ZNNTYQTTYBNQGY-NOYBBXANSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(5-iodo-2-isobutyramido-4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C46H56IN6O9P/c1-28(2)42(54)50-45-49-41-38(43(55)51-45)36(47)26-52(41)44-40(58-9)39(62-63(60-25-13-24-48)53(29(3)4)30(5)6)37(61-44)27-59-46(31-14-11-10-12-15-31,32-16-20-34(56-7)21-17-32)33-18-22-35(57-8)23-19-33/h10-12,14-23,26,28-30,37,39-40,44H,13,25,27H2,1-9H3,(H2,49,50,51,54,55)/t37-,39-,40-,44-,63?/m1/s1

Synonyms: 7-Iodo 7-deaza 2'-O-Methyl G(iBu) 3'-CE phosphoramidite

7-deaza 7-propargyl 2'-O-Methyl Adenosine CED phosphoramidite

Description: 7-deaza 7-propargyl 2'-O-Methyl Adenosine CED phosphoramidite is a specialized reagent used in oligonucleotide synthesis to introduce a modified form of adenosine into nucleic acid sequences. This modification includes replacing the nitrogen atom at the 7-position of the purine ring with a carbon atom linked to a propargyl group, creating a 7-deaza 7-propargyl adenosine. Additionally, it features an O-methyl group at the 2'-position of the ribose sugar and a benzoyl (Bz) protecting group at the nucleobase. Furthermore, it includes a cyanoethyl (CE) protecting group at the 3'-position, facilitating its incorporation into oligonucleotides during solid-phase synthesis. This reagent enables the synthesis of oligonucleotides with specific chemical modifications, suitable for various research and diagnostic applications in molecular biology and biotechnology.

CAT: BRP-01391

Molecular Formula: C54H57F3N7O9P

Molecular Weight: 1036.04

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InChIKey: MWDGGUITMWBQOX-QLWGAVRDSA-N

IUPAC Name: (2R,3R,4R,5R)-5-(4-benzamido-5-(3-(2,2,2-trifluoroacetamido)prop-1-yn-1-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C54H57F3N7O9P/c1-35(2)64(36(3)4)74(71-31-15-29-58)73-46-44(33-70-53(39-19-12-9-13-20-39,40-21-25-42(67-5)26-22-40)41-23-27-43(68-6)28-24-41)72-51(47(46)69-7)63-32-38(18-14-30-59-52(66)54(55,56)57)45-48(60-34-61-49(45)63)62-50(65)37-16-10-8-11-17-37/h8-13,16-17,19-28,32,34-36,44,46-47,51H,15,30-31,33H2,1-7H3,(H,59,66)(H,60,61,62,65)/t44-,46-,47-,51-,74?/m1/s1

Synonyms: 7-deaza 7-propargyl 2'-O-Methyl A(Bz) 3'-CE phosphoramidite

7-deaza 7-propargyl 2'-O-Methyl Guanosine CED phosphoramidite

Description: 7-deaza 7-propargyl 2'-O-Methyl Guanosine CED phosphoramidite is a specialized reagent used in oligonucleotide synthesis to modify guanosine. It incorporates a propargyl group at the 7-position and an O-methyl group at the 2'-position of the ribose sugar, with an isobutyryl protecting group on the guanosine base and a cyanoethyl protecting group at the 3'-position, facilitating its integration into oligonucleotides during synthesis.

CAT: BRP-01392

Molecular Formula: C51H59F3N7O10P

Molecular Weight: 1018.02

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InChIKey: SZPSULVVPSSTMY-KBAKYSIRSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-4-oxo-5-(3-(2,2,2-trifluoroacetamido)prop-1-yn-1-yl)-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C51H59F3N7O10P/c1-31(2)45(62)58-49-57-44-41(46(63)59-49)34(15-13-27-56-48(64)51(52,53)54)29-60(44)47-43(67-9)42(71-72(69-28-14-26-55)61(32(3)4)33(5)6)40(70-47)30-68-50(35-16-11-10-12-17-35,36-18-22-38(65-7)23-19-36)37-20-24-39(66-8)25-21-37/h10-12,16-25,29,31-33,40,42-43,47H,14,27-28,30H2,1-9H3,(H,56,64)(H2,57,58,59,62,63)/t40-,42-,43-,47-,72?/m1/s1

Synonyms: 7-deaza 7-propargyl 2'-O-Methyl G(iBu) 3'-CE phosphoramidite

Amino Modifier 2'-O-Methyl Uridine CED phosphoramidite

Description: Amino Modifier 2'-O-Methyl Uridine CED phosphoramidite is a specialized reagent used in oligonucleotide synthesis to introduce a modification at the 2'-position of the ribose sugar of uridine. Additionally, it features a cyanoethyl (CED) protecting group, facilitating its incorporation into oligonucleotides during solid-phase synthesis. This reagent allows for the synthesis of oligonucleotides with specific chemical modifications, suitable for various research and diagnostic applications in molecular biology and biotechnology.

CAT: BRP-01394

Molecular Formula: C51H64F3N6O11P

Molecular Weight: 1025.06

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InChIKey: GOWRXIMHDVBFES-MVOVHUSBSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-5-((E)-3-oxo-3-((6-(2,2,2-trifluoroacetamido)hexyl)amino)prop-1-en-1-yl)-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C51H64F3N6O11P/c1-34(2)60(35(3)4)72(69-31-15-28-55)71-44-42(33-68-50(37-16-11-10-12-17-37,38-19-23-40(65-5)24-20-38)39-21-25-41(66-6)26-22-39)70-47(45(44)67-7)59-32-36(46(62)58-49(59)64)18-27-43(61)56-29-13-8-9-14-30-57-48(63)51(52,53)54/h10-12,16-27,32,34-35,42,44-45,47H,8-9,13-15,29-31,33H2,1-7H3,(H,56,61)(H,57,63)(H,58,62,64)/b27-18+/t42-,44-,45-,47-,72?/m1/s1

Synonyms: Amino Modifier 2'-O-Methyl Uridine 3'-CE phosphoramidite

5-Propynyl-2'-O-Methyl Uridine CED phosphoramidite

Description: 5-Propynyl-2'-O-Methyl Uridine CED phosphoramidite is a specialized reagent used in oligonucleotide synthesis. It incorporates a modified form of uridine into nucleic acid sequences. This modification includes a propynyl group at the 5-position and an O-methyl group at the 2'-position of the ribose sugar. Additionally, it features a cyanoethyl (CED) protecting group, facilitating its incorporation into oligonucleotides during solid-phase synthesis. This reagent enables the synthesis of oligonucleotides with specific chemical modifications, suitable for various research and diagnostic applications in molecular biology and biotechnology.

CAT: BRP-01396

Molecular Formula: C43H51N4O9P

Molecular Weight: 798.86

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InChIKey: XOVYKNVGMJSHSM-DRQVPZTESA-N

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-5-(prop-1-yn-1-yl)-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C43H51N4O9P/c1-9-14-31-27-46(42(49)45-40(31)48)41-39(52-8)38(56-57(54-26-13-25-44)47(29(2)3)30(4)5)37(55-41)28-53-43(32-15-11-10-12-16-32,33-17-21-35(50-6)22-18-33)34-19-23-36(51-7)24-20-34/h10-12,15-24,27,29-30,37-39,41H,13,26,28H2,1-8H3,(H,45,48,49)/t37-,38-,39-,41-,57?/m1/s1

Synonyms: 5-Propynyl-2'-O-Methyl Uridine 3'-CE phosphoramidite

7-deaza-2'-O-Methyl Adenosine CED phosphoramidite

Description: 7-deaza-2'-O-Methyl Adenosine CED phosphoramidite is a specialized reagent used in oligonucleotide synthesis. It introduces a modified form of adenosine into nucleic acid sequences. This modification includes a 7-deaza substitution, where the nitrogen atom at the 7-position of the purine ring is replaced with a carbon atom, as well as an O-methyl group at the 2'-position of the ribose sugar. Additionally, it features a benzoyl (Bz) protecting group at the nucleobase and a cyanoethyl (CE) protecting group at the 3'-position, facilitating its incorporation into oligonucleotides during solid-phase synthesis. This reagent enables the synthesis of oligonucleotides with specific chemical modifications, suitable for various research and diagnostic applications in molecular biology and biotechnology.

CAT: BRP-01397

Molecular Formula: C49H55N6O8P

Molecular Weight: 886.97

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InChIKey: ILOKJXWUUOTGTB-SQPGCJOQSA-N

IUPAC Name: (2R,3R,4R,5R)-5-(4-benzamido-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C49H55N6O8P/c1-33(2)55(34(3)4)64(61-30-14-28-50)63-43-42(62-48(44(43)59-7)54-29-27-41-45(51-32-52-46(41)54)53-47(56)35-15-10-8-11-16-35)31-60-49(36-17-12-9-13-18-36,37-19-23-39(57-5)24-20-37)38-21-25-40(58-6)26-22-38/h8-13,15-27,29,32-34,42-44,48H,14,30-31H2,1-7H3,(H,51,52,53,56)/t42-,43-,44-,48-,64?/m1/s1

Synonyms: 7-deaza 2'-O-Methyl A(Bz) 3'-CE phosphoramidite

8-methyl-rGuanosine(n-ibu) 2'-TBDMS-3'-CE phosphoramidite

Description: 8-methyl-rGuanosine(n-ibu) 2'-TBDMS-3'-CE phosphoramidite is a modified nucleoside phosphoramidite with a tert-butyldimethylsilyl (TBDMS) protecting group on the 2' position and a 3'-CE protecting group. It contains an isobutyryl (n-ibu) group on the nitrogen atom of the guanine base at the 8 position. This phosphoramidite is commonly used in the synthesis of modified RNA molecules for research purposes.

CAT: BRP-01402

CAS: 634612-49-0

Molecular Formula: C51H70N7O9PSi

Molecular Weight: 984.20

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InChIKey: BVKTTXBRRDYOEU-MGIZDRFQSA-N

CanonicalSMILES: CC1=NC2=C(N1C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N(C(C)C)C(C)C)OCCC#N)O[Si](C)(C)C(C)(C)C)N=C(NC2=O)NC(=O)C(C)C

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]-8-methyl-6-oxo-1H-purin-2-yl]-2-methylpropanamide

InChI: InChI=1S/C51H70N7O9PSi/c1-32(2)46(59)55-49-54-45-42(47(60)56-49)53-35(7)57(45)48-44(67-69(13,14)50(8,9)10)43(66-68(64-30-18-29-52)58(33(3)4)34(5)6)41(65-48)31-63-51(36-19-16-15-17-20-36,37-21-25-39(61-11)26-22-37)38-23-27-40(62-12)28-24-38/h15-17,19-28,32-34,41,43-44,48H,18,30-31H2,1-14H3,(H2,54,55,56,59,60)/t41-,43-,44-,48-,68?/m1/s1

Synonyms: Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-8-methyl-N-(2-methyl-1-oxopropyl)-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; 8-methyl-2'-TBDMS-G(iBu)-3'-CE phosphoramidite

2'-tBDSilyl 2-Amino Purine Ribosine (n,n-dmf) 3'-CE phosphoramidite

Description: 2'-tBDSilyl 2-Amino Purine Ribosine (n,n-dmf) 3'-CE phosphoramidite is a modified nucleoside phosphoramidite used in solid-phase synthesis of nucleic acids. This compound is useful for the synthesis of modified nucleic acids with enhanced properties for various applications.

CAT: BRP-01404

CAS: 1643773-48-1

Molecular Formula: C49H67N8O7PSi

Molecular Weight: 939.17

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InChIKey: BJXKSHKSYZVPKC-WMHLWPNPSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C=NC(N=CN(C)C)=NC32)C1O[Si](C)(C)C(C)(C)C)COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2-(((dimethylamino)methylene)amino)-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C49H67N8O7PSi/c1-34(2)57(35(3)4)65(61-29-17-28-50)63-43-42(31-60-49(36-18-15-14-16-19-36,37-20-24-39(58-10)25-21-37)38-22-26-40(59-11)27-23-38)62-46(44(43)64-66(12,13)48(5,6)7)56-33-52-41-30-51-47(54-45(41)56)53-32-55(8)9/h14-16,18-27,30,32-35,42-44,46H,17,29,31H2,1-13H3/t42-,43-,44-,46-,65?/m1/s1

Synonyms: Methanimidamide, N'-[9-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-O-[(1,1-dimethylethyl)dimethylsilyl]-β-D-ribofuranosyl]-9H-purin-2-yl]-N,N-dimethyl-; N'-[9-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-O-[(1,1-dimethylethyl)dimethylsilyl]-β-D-ribofuranosyl]-9H-purin-2-yl]-N,N-dimethylmethanimidamide; 2'-tBDSilyl 2-Amino Purine Ribosine (n,n-dmf) CED OP

Adenosine-(N-Bz)-Methylene oxy-DMTr-Morpholino, cyanoethyl-N,N-diisopropyl diphosphoramidite

Description: Adenosine-(N-Bz)-Methylene oxy-DMTr-Morpholino, cyanoethyl-N,N-diisopropyl diphosphoramidite is a chemical compound used in the synthesis of nucleic acids. It is a modified nucleoside phosphoramidite, which is used in solid-phase synthesis of oligonucleotides. This compound contains a modified adenosine base, a morpholino group, a cyanoethyl group, and a diisopropyl phosphoramidite group, all of which play important roles in the synthesis of high-quality oligonucleotides. The presence of the N-Benzoyl (Bz) group protects the amine functionality of the adenosine base during synthesis, while the morpholino group is used to enhance the hybridization properties of the oligonucleotide. The cyanoethyl and diisopropyl groups are used as leaving groups during the coupling reactions in the solid-phase synthesis. Overall, this compound is an important building block in the synthesis of modified oligonucleotides for various applications in molecular biology and biotechnology.

CAT: BRP-01408

CAS: 2243974-80-1

Molecular Formula: C47H53N8O6P

Molecular Weight: 856.95

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InChIKey: ZRWXOZTUFQZCLQ-UHFFFAOYSA-N

CanonicalSMILES: N#CCCOP(N1CC(OC(COC(C=2C=CC=CC2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)C1)N5C=NC=6C(=NC=NC65)NC(=O)C=7C=CC=CC7)N(C(C)C)C(C)C

IUPAC Name: N-(9-((2R,6S)-6-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((2-cyanoethoxy)(diisopropylamino)phosphaneyl)morpholin-2-yl)-9H-purin-6-yl)benzamide

InChI: InChI=1S/C47H53N8O6P/c1-33(2)55(34(3)4)62(60-27-13-26-48)53-28-41(61-42(29-53)54-32-51-43-44(49-31-50-45(43)54)52-46(56)35-14-9-7-10-15-35)30-59-47(36-16-11-8-12-17-36,37-18-22-39(57-5)23-19-37)38-20-24-40(58-6)25-21-38/h7-12,14-25,31-34,41-42H,13,27-30H2,1-6H3,(H,49,50,52,56)

Cytidine-(N-Bz)-Methylene oxy-DMTr-Morpholino, cyanoethyl-N,N-diisopropyl diphosphoramidite

Description: Cytidine-(N-Bz)-Methylene oxy-DMTr-Morpholino, cyanoethyl-N,N-diisopropyl diphosphoramidite is a chemical compound used in the synthesis of nucleic acids, specifically in the process of solid-phase oligonucleotide synthesis. It is a modified cytidine residue with a benzoyl (Bz) protecting group on the amine group, a dimethoxytrityl (DMTr) protecting group on the hydroxyl group, and a morpholino group on the phosphate backbone. The cyanoethyl-N,N-diisopropyl diphosphoramidite is the phosphoramidite derivative used for coupling the cytidine residue to the growing oligonucleotide chain. This compound allows for efficient and selective incorporation of cytidine into the oligonucleotide sequence during synthesis.

CAT: BRP-01409

CAS: 2304678-30-4

Molecular Formula: C46H53N6O7P

Molecular Weight: 832.92

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InChIKey: SOMSQNICPOHJHU-UQSDLCBCSA-N

CanonicalSMILES: N#CCCOP(N1CC(OC(COC(C=2C=CC=CC2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)C1)N5C=CC(=NC5=O)NC(=O)C=6C=CC=CC6)N(C(C)C)C(C)C

IUPAC Name: N-(1-((2R,6S)-6-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((2-cyanoethoxy)(diisopropylamino)phosphaneyl)morpholin-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide

InChI: InChI=1S/C46H53N6O7P/c1-33(2)52(34(3)4)60(58-29-13-27-47)50-30-41(59-43(31-50)51-28-26-42(49-45(51)54)48-44(53)35-14-9-7-10-15-35)32-57-46(36-16-11-8-12-17-36,37-18-22-39(55-5)23-19-37)38-20-24-40(56-6)25-21-38/h7-12,14-26,28,33-34,41,43H,13,29-32H2,1-6H3,(H,48,49,53,54)/t41-,43+,60?/m0/s1

Synonyms: Phosphonamidous acid, P-[(2R,6S)-2-[4-(benzoylamino)-2-oxo-1(2H)-pyrimidinyl]-6-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-4-morpholinyl]-N,N-bis(1-methylethyl)-, 2-cyanoethyl ester

Guanosine-(N2-iBu)-Methylene oxy-DMTr-Morpholino, cyanoethyl-N,N-diisopropyl diphosphoramidite

Description: Guanosine-(N2-iBu)-Methylene oxy-DMTr-Morpholino, cyanoethyl-N,N-diisopropyl diphosphoramidite is a compound used in organic synthesis for the modification of nucleosides and nucleotides. It is a phosphoramidite derivative that can be used in the synthesis of modified RNA molecules for various research purposes. The compound contains a guanosine base modified at the N2 position with an isobutyl group, a methyleneoxy linker, a dimethoxytrityl (DMTr) protecting group, and a morpholino moiety. The cyanoethyl-N,N-diisopropyl diphosphoramidite group allows for efficient coupling reactions during RNA synthesis.

CAT: BRP-01410

CAS: 2243974-81-2

Molecular Formula: C44H55N8O7P

Molecular Weight: 838.93

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InChIKey: HQRPMELFURAQPY-VMZRNFFESA-N

CanonicalSMILES: N#CCCOP(N1CC(OC(COC(C=2C=CC=CC2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)C1)N5C=NC=6C(=O)N=C(NC(=O)C(C)C)NC65)N(C(C)C)C(C)C

IUPAC Name: N-(9-((2R,6S)-6-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((2-cyanoethoxy)(diisopropylamino)phosphaneyl)morpholin-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide

InChI: InChI=1S/C44H55N8O7P/c1-29(2)41(53)48-43-47-40-39(42(54)49-43)46-28-51(40)38-26-50(60(58-24-12-23-45)52(30(3)4)31(5)6)25-37(59-38)27-57-44(32-13-10-9-11-14-32,33-15-19-35(55-7)20-16-33)34-17-21-36(56-8)22-18-34/h9-11,13-22,28-31,37-38H,12,24-27H2,1-8H3,(H2,47,48,49,53,54)/t37-,38+,60?/m0/s1

N3-Thiobenzoylethyl 2'-TBDMS Uridine 3'-CE phosphoramidite

Description: N3-Thiobenzoylethyl Uridine CED phosphoramidite is a compound used in oligonucleotide synthesis. It features uridine with a 2'-tert-butyldimethylsilyl (TBDMS) group, protecting the 2'-hydroxyl group, and a N3-thiobenzoylethyl group at the nitrogen atom of the uracil ring. Additionally, it includes a cyanoethyl (CE) group at the 3'-position and is attached to a phosphoramidite moiety for solid-phase synthesis. This compound facilitates the controlled synthesis of modified oligonucleotides, enabling precise chemical modifications and enhancing stability.

CAT: BRP-01413

Molecular Formula: C54H69N4O10PSSi

Molecular Weight: 1025.27

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InChIKey: QVVPMOVSGPVKRC-IHMJTFHYSA-N

IUPAC Name: S-(2-(3-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)tetrahydrofuran-2-yl)-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)ethyl) benzothioate

InChI: InChI=1S/C54H69N4O10PSSi/c1-38(2)58(39(3)4)69(65-35-18-32-55)67-48-46(37-64-54(41-21-16-13-17-22-41,42-23-27-44(62-8)28-24-42)43-25-29-45(63-9)30-26-43)66-50(49(48)68-71(10,11)53(5,6)7)57-33-31-47(59)56(52(57)61)34-36-70-51(60)40-19-14-12-15-20-40/h12-17,19-31,33,38-39,46,48-50H,18,34-37H2,1-11H3/t46-,48-,49-,50-,69?/m1/s1

Synonyms: N3-Thiobenzoylethyl Uridine CED phosphoramidite

N6-Benzyl 2'-TBDMS Adenosine CED phosphoramidite

Description: N6-Benzyl 2'-TBDMS Adenosine CED phosphoramidite is used in the solid-phase synthesis of RNA molecules. The N6-benzyl and 2'-TBDMS (tert-butyldimethylsilyl) protecting groups are commonly used to protect specific functional groups on the nucleoside, allowing for selective deprotection and further modification during the synthesis process. The CED (cyclohexyl-N,N-diisopropylaminoethyl) group is a phosphoramidite moiety used to facilitate the attachment of the nucleoside to the solid support during synthesis. This modified phosphoramidite is widely used in the field of nucleic acid chemistry for the synthesis of RNA molecules with specific modifications at the adenosine nucleoside position.

CAT: BRP-01414

Molecular Formula: C53H68N7O7PSi

Molecular Weight: 974.21

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InChIKey: GZBJCGYSXUSQQJ-MGEVAVFRSA-N

IUPAC Name: (2R,3R,4R,5R)-5-(6-(benzylamino)-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C53H68N7O7PSi/c1-37(2)60(38(3)4)68(64-32-18-31-54)66-47-45(34-63-53(40-21-16-13-17-22-40,41-23-27-43(61-8)28-24-41)42-25-29-44(62-9)30-26-42)65-51(48(47)67-69(10,11)52(5,6)7)59-36-58-46-49(56-35-57-50(46)59)55-33-39-19-14-12-15-20-39/h12-17,19-30,35-38,45,47-48,51H,18,32-34H2,1-11H3,(H,55,56,57)/t45-,47-,48-,51-,68?/m1/s1

Synonyms: Adenosine, N-Benzyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; 2'-TBDMS A(Bn) 3'-CE phosphoramidite; N6-Benzyl Adenosine CED phosphoramidite

N6-Isopentenyl 2'-TBDMS Adenosine CED phosphoramidite

Description: N6-Isopentenyl 2'-TBDMS Adenosine CED phosphoramidite is a reagent used in solid-phase synthesis of oligonucleotides. It contains a modified adenosine nucleoside with a TBDMS (tert-butyldimethylsilyl) group at the 2'-position and a CED (2-cyanoethyl-N,N-diisopropyl) phosphoramidite group at the N6-position. This phosphoramidite derivative allows for efficient and selective coupling reactions during the synthesis of modified oligonucleotides.

CAT: BRP-01416

Molecular Formula: C51H70N7O7PSi

Molecular Weight: 952.20

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InChIKey: WCJAFYSVXPNXPT-VVPIBMPJSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(6-((3-methylbut-2-en-1-yl)amino)-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C51H70N7O7PSi/c1-35(2)28-30-53-47-44-48(55-33-54-47)57(34-56-44)49-46(65-67(12,13)50(7,8)9)45(64-66(62-31-17-29-52)58(36(3)4)37(5)6)43(63-49)32-61-51(38-18-15-14-16-19-38,39-20-24-41(59-10)25-21-39)40-22-26-42(60-11)27-23-40/h14-16,18-28,33-34,36-37,43,45-46,49H,17,30-32H2,1-13H3,(H,53,54,55)/t43-,45-,46-,49-,66?/m1/s1

Synonyms: N6-Isopentenyl Adenosine CED phosphoramidite; N6-Isopentenyl 2'-TBDMS rA 3'-CE phosphoramidite

2'-O-PivOM-5'-O-DMT-Guanosine (N-ipr-PAC) 3'-CEP

Description: 2'-O-PivOM-5'-O-DMT-Guanosine (N-ipr-PAC) 3'-CEP is a specialized nucleotide used in the synthesis of modified oligonucleotides. It features protective groups for the 2'- and 5'-hydroxyls, the N2 amino group, and the 3'-hydroxyl, facilitating the stepwise addition of nucleotides during solid-phase synthesis. This compound is crucial for creating RNA and DNA molecules with enhanced stability and functionality, making it valuable in biochemical and medical research.

CAT: BRP-01423

CAS: 1792219-30-7

Molecular Formula: C57H70N7O12P

Molecular Weight: 1076.18

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InChIKey: NPTZAQHIJAFZFD-AGVGNCMWSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C(=O)N=C(NC(=O)COC4=CC=C(C=C4)C(C)C)NC32)C1OCOC(=O)C(C)(C)C)COC(C=5C=CC=CC5)(C6=CC=C(OC)C=C6)C7=CC=C(OC)C=C7)N(C(C)C)C(C)C

IUPAC Name: (((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-2-(2-(2-(4-isopropylphenoxy)acetamido)-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl)oxy)methyl pivalate

InChI: InChI=1S/C57H70N7O12P/c1-36(2)39-18-24-45(25-19-39)70-33-47(65)60-55-61-51-48(52(66)62-55)59-34-63(51)53-50(71-35-72-54(67)56(7,8)9)49(76-77(74-31-15-30-58)64(37(3)4)38(5)6)46(75-53)32-73-57(40-16-13-12-14-17-40,41-20-26-43(68-10)27-21-41)42-22-28-44(69-11)29-23-42/h12-14,16-29,34,36-38,46,49-50,53H,15,31-33,35H2,1-11H3,(H2,60,61,62,65,66)/t46-,49-,50-,53-,77?/m1/s1

Synonyms: 2'-OPivOM G(ipr-pac) amidite; Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(2,2-dimethyl-1-oxopropoxy)methyl]-N-[2-[4-(1-methylethyl)phenoxy]acetyl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; 2'-O-PivOM-5'-O-DMT-Guanosine (N-ipr-PAC) 3'-CE phosphoramidite

Beta-L-2'-tBDSilyl Cytidine (n-bz) 3'-CED phosphoramidite

5-Iodo Uridine 2'-O-Methyl CED phosphoramidite

Amino Modifier 2'-O-Methyl C(dmf) 3'-CE phosphoramidite

5-Propynyl-2'-O-Methyl Cytidine CED phosphoramidite

7-Iodo 7-deaza 2'-O-Methyl Adenosine CED phosphoramidite

7-Iodo 7-deaza 2'-O-Methyl Guanosine CED phosphoramidite

7-deaza 7-propargyl 2'-O-Methyl Adenosine CED phosphoramidite

7-deaza 7-propargyl 2'-O-Methyl Guanosine CED phosphoramidite

Amino Modifier 2'-O-Methyl Uridine CED phosphoramidite

5-Propynyl-2'-O-Methyl Uridine CED phosphoramidite

7-deaza-2'-O-Methyl Adenosine CED phosphoramidite

8-methyl-rGuanosine(n-ibu) 2'-TBDMS-3'-CE phosphoramidite

2'-tBDSilyl 2-Amino Purine Ribosine (n,n-dmf) 3'-CE phosphoramidite

Adenosine-(N-Bz)-Methylene oxy-DMTr-Morpholino, cyanoethyl-N,N-diisopropyl diphosphoramidite

Cytidine-(N-Bz)-Methylene oxy-DMTr-Morpholino, cyanoethyl-N,N-diisopropyl diphosphoramidite

Guanosine-(N2-iBu)-Methylene oxy-DMTr-Morpholino, cyanoethyl-N,N-diisopropyl diphosphoramidite

N3-Thiobenzoylethyl 2'-TBDMS Uridine 3'-CE phosphoramidite

N6-Benzyl 2'-TBDMS Adenosine CED phosphoramidite

N6-Isopentenyl 2'-TBDMS Adenosine CED phosphoramidite

2'-O-PivOM-5'-O-DMT-Guanosine (N-ipr-PAC) 3'-CEP

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