Phosphoramidites - RNA / BOC Sciences

DMTr-2'-O-MOEOE-rG(iBu)-3'-CE-Phosphoramidite

Description: DMTr-2'-O-MOEOE-rG(iBu)-3'-CE-Phosphoramidite, utilized in oligonucleotide synthesis, contains a methoxyethoxy (MOEOE) group at the 2'-O position and an isobutyryl (iBu) protecting group on the guanine amino group. The 3'-end is functionalized with a cyanoethyl (CE) group, facilitating efficient coupling reactions during solid-phase synthesis. It is employed to introduce modified guanine residues into nucleic acid sequences, enhancing stability and target specificity for applications such as RNA research, gene silencing, and aptamer development.

CAT: BRP-00622

MF: C49H64N7O11P

MF: 958.06

Purity: ≥95%

Appearance: White, off-white to faint yellow powder

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InChIKey: OATUMETWWCLSRW-LCVXBTAASA-N

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(2-(2-methoxyethoxy)ethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C49H64N7O11P/c1-32(2)45(57)53-48-52-44-41(46(58)54-48)51-31-55(44)47-43(63-29-28-62-27-26-59-7)42(67-68(65-25-13-24-50)56(33(3)4)34(5)6)40(66-47)30-64-49(35-14-11-10-12-15-35,36-16-20-38(60-8)21-17-36)37-18-22-39(61-9)23-19-37/h10-12,14-23,31-34,40,42-43,47H,13,25-30H2,1-9H3,(H2,52,53,54,57,58)/t40-,42-,43-,47-,68?/m1/s1

Synonyms: 2'-MOEOE rG(iBu) amidite; N2-iBu-DMT-2'-O-MOEOE-Gr-CE-Phosphoramidite; N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(2-(2-Methoxyethoxy)ethyl)-guanosine-3'-cyanoethyl Phosphoramidite

DMTr-2'-O-MOEOE-rA(Bz)-3'-CE-Phosphoramidite

Description: DMTr-2'-O-MOEOE-rA(Bz)-3'-CE-Phosphoramidite is utilized in oligonucleotide synthesis, featuring a methoxyethoxy (MOEOE) group at the 2'-O position and a benzoyl (Bz) protecting group on the adenine amino group. The 3'-end is functionalized with a cyanoethyl (CE) group, facilitating efficient coupling reactions during solid-phase synthesis. It is employed to introduce modified adenine residues into nucleic acid sequences, enhancing stability and target specificity for various molecular biology applications, including RNA labeling, structural studies, and gene regulation research.

CAT: BRP-00623

MF: C52H62N7O10P

MF: 976.08

Purity: ≥95%

Appearance: Off-white solid

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InChIKey: PKYUXPBRGLVQBQ-MABFDDSHSA-N

Solubility: Soluble in Acetonitrile, DMF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OCCOCCOC)N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-[2-(2-methoxyethoxy)ethoxy]oxolan-2-yl]purin-6-yl]benzamide

InChI: InChI=1S/C52H62N7O10P/c1-36(2)59(37(3)4)70(67-28-14-27-53)69-46-44(33-66-52(39-17-12-9-13-18-39,40-19-23-42(62-6)24-20-40)41-21-25-43(63-7)26-22-41)68-51(47(46)65-32-31-64-30-29-61-5)58-35-56-45-48(54-34-55-49(45)58)57-50(60)38-15-10-8-11-16-38/h8-13,15-26,34-37,44,46-47,51H,14,28-33H2,1-7H3,(H,54,55,57,60)/t44-,46-,47-,51-,70?/m1/s1

Synonyms: (2R,3R,4R,5R)-5-(6-Benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-(2-methoxyethoxy)ethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; 2'-MOEOE A(Bz) amidite; N6-Bz-DMT-2'-O-MOEOE-Ar-CE-Phosphoramidite; N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(2-(2-Methoxyethoxy)ethyl)-adenosine-3'-cyanoethyl Phosphoramidite

DMTr-2'-O-Bu-rA(Bz)-3'-CE-Phosphoramidite

Description: DMTr-2'-O-Bu-rA(Bz)-3'-CE-Phosphoramidite, used in oligonucleotide synthesis, features a butyl (Bu) group at the 2'-O position, and a benzoyl (Bz) protecting group on the adenine amino group. The 3'-end is functionalized with a cyanoethyl (CE) group, facilitating efficient coupling reactions during solid-phase synthesis. It is employed to introduce modified adenine residues into nucleic acid sequences, enhancing stability and target specificity for applications such as RNA labeling, structural studies, and gene regulation research.

CAT: BRP-00624

MF: C51H60N7O8P

MF: 930.06

Purity: ≥95%

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InChIKey: PGNPDHTYAGNPAM-LTMMGAFGSA-N

CanonicalSMILES: CCCCOC1C(C(OC1N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC)OP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-butoxy-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]purin-6-yl]benzamide

InChI: InChI=1S/C51H60N7O8P/c1-8-9-30-62-46-45(66-67(64-31-16-29-52)58(35(2)3)36(4)5)43(65-50(46)57-34-55-44-47(53-33-54-48(44)57)56-49(59)37-17-12-10-13-18-37)32-63-51(38-19-14-11-15-20-38,39-21-25-41(60-6)26-22-39)40-23-27-42(61-7)28-24-40/h10-15,17-28,33-36,43,45-46,50H,8-9,16,30-32H2,1-7H3,(H,53,54,56,59)/t43-,45-,46-,50-,67?/m1/s1

Synonyms: (2R,3R,4R,5R)-5-(6-Benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-butoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

DMTr-2'-O-Et-rA(Bz)-3'-CE-Phosphoramidite

Description: DMTr-2'-O-Et-rA(Bz)-3'-CE-Phosphoramidite, utilized in oligonucleotide synthesis, contains an ethyl (Et) group at the 2'-O position, and a benzoyl (Bz) protecting group on the adenine amino group. The 3'-end is functionalized with a cyanoethyl (CE) group, facilitating efficient coupling reactions during solid-phase synthesis. It is employed to introduce modified adenine residues into nucleic acid sequences, enhancing stability and target specificity for various molecular biology applications, including RNA labeling, gene synthesis, and RNA interference studies.

CAT: BRP-00625

MF: C49H56N7O8P

MF: 902.00

Purity: ≥95%

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InChIKey: BWEYMSXPRQAMFY-FVPMUMJWSA-N

CanonicalSMILES: CCOC1C(C(OC1N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC)OP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-ethoxyoxolan-2-yl]purin-6-yl]benzamide

InChI: InChI=1S/C49H56N7O8P/c1-8-60-44-43(64-65(62-29-15-28-50)56(33(2)3)34(4)5)41(63-48(44)55-32-53-42-45(51-31-52-46(42)55)54-47(57)35-16-11-9-12-17-35)30-61-49(36-18-13-10-14-19-36,37-20-24-39(58-6)25-21-37)38-22-26-40(59-7)27-23-38/h9-14,16-27,31-34,41,43-44,48H,8,15,29-30H2,1-7H3,(H,51,52,54,57)/t41-,43-,44-,48-,65?/m1/s1

Synonyms: (2R,3R,4R,5R)-5-(6-Benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-ethoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

DMTr-2'-O-Bu-5-Me-rC(Bz)-3'-CE-Phosphoramidite

Description: DMTr-2'-O-Bu-5-Me-rC(Bz)-3'-CE-Phosphoramidite, utilized in oligonucleotide synthesis, features a butyl (Bu) group at the 2'-O position, and a benzoyl (Bz) protecting group on the 5-methylcytosine (5-Me-rC) amino group. The 3'-end is functionalized with a cyanoethyl (CE) group, facilitating efficient coupling reactions during solid-phase synthesis. It is employed to introduce modified cytosine residues into nucleic acid sequences, enhancing stability and target specificity for applications such as RNA labeling, probing, and therapeutic development.

CAT: BRP-00626

MF: C51H62N5O9P

MF: 920.06

Purity: ≥95%

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InChIKey: JRVKTZYKHMIWMA-BZPNBFHRSA-N

IUPAC Name: (2R,3R,4R,5R)-5-(4-benzamido-5-methyl-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-butoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C51H62N5O9P/c1-9-10-31-61-46-45(65-66(63-32-17-30-52)56(35(2)3)36(4)5)44(64-49(46)55-33-37(6)47(54-50(55)58)53-48(57)38-18-13-11-14-19-38)34-62-51(39-20-15-12-16-21-39,40-22-26-42(59-7)27-23-40)41-24-28-43(60-8)29-25-41/h11-16,18-29,33,35-36,44-46,49H,9-10,17,31-32,34H2,1-8H3,(H,53,54,57,58)/t44-,45-,46-,49-,66?/m1/s1

DMTr-2'-O-Et-5-Me-rC(Bz)-3'-CE-Phosphoramidite

Description: DMTr-2'-O-Et-5-Me-rC(Bz)-3'-CE-Phosphoramidite, utilized in oligonucleotide synthesis, features an ethyl (Et) group at the 2'-O position, and a benzoyl (Bz) protecting group on the 5-methylcytosine (5-Me-rC) amino group. The 3'-end is functionalized with a cyanoethyl (CE) group, facilitating efficient coupling reactions during solid-phase synthesis. It is employed to introduce modified cytosine residues into nucleic acid sequences, enhancing stability and target specificity for various research applications, including RNA labeling, probing, and therapeutic development.

CAT: BRP-00627

MF: C49H58N5O9P

MF: 892.00

Purity: ≥95%

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InChIKey: NKWGOVVNANYUQH-ADJAFLDTSA-N

IUPAC Name: (2R,3R,4R,5R)-5-(4-benzamido-5-methyl-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-ethoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C49H58N5O9P/c1-9-59-44-43(63-64(61-30-16-29-50)54(33(2)3)34(4)5)42(62-47(44)53-31-35(6)45(52-48(53)56)51-46(55)36-17-12-10-13-18-36)32-60-49(37-19-14-11-15-20-37,38-21-25-40(57-7)26-22-38)39-23-27-41(58-8)28-24-39/h10-15,17-28,31,33-34,42-44,47H,9,16,30,32H2,1-8H3,(H,51,52,55,56)/t42-,43-,44-,47-,64?/m1/s1

DMTr-2'-O-Bu-rG(iBu)-3'-CE-Phosphoramidite

Description: DMTr-2'-O-Bu-rG(iBu)-3'-CE-Phosphoramidite is used in oligonucleotide synthesis, featuring a butyl (Bu) group at the 2'-O position, and an isobutyryl (iBu) protecting group on the guanine amino group. The 3'-end is functionalized with a cyanoethyl (CE) group, facilitating efficient coupling reactions during solid-phase synthesis. It is employed to introduce modified guanine residues into nucleic acid sequences, enhancing stability and target specificity for applications such as RNA labeling, probing, and therapeutic development.

CAT: BRP-00628

MF: C48H62N7O9P

MF: 912.04

Purity: ≥95%

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InChIKey: BOYCEYCODXCBOY-VKFKYRIUSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-butoxy-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C48H62N7O9P/c1-10-11-27-60-42-41(64-65(62-28-15-26-49)55(32(4)5)33(6)7)39(63-46(42)54-30-50-40-43(54)51-47(53-45(40)57)52-44(56)31(2)3)29-61-48(34-16-13-12-14-17-34,35-18-22-37(58-8)23-19-35)36-20-24-38(59-9)25-21-36/h12-14,16-25,30-33,39,41-42,46H,10-11,15,27-29H2,1-9H3,(H2,51,52,53,56,57)/t39-,41-,42-,46-,65?/m1/s1

DMTr-2'-O-Et-rG(iBu)-3'-CE-Phosphoramidite

Description: DMTr-2'-O-Et-rG(iBu)-3'-CE-Phosphoramidite, utilized in oligonucleotide synthesis, contains an ethyl (Et) group at the 2'-O position, and an isobutyryl (iBu) protecting group on the guanine amino group. The 3'-end is functionalized with a cyanoethyl (CE) group, facilitating efficient coupling reactions during solid-phase synthesis. It is employed to introduce modified guanine residues into nucleic acid sequences, enhancing stability and target specificity for various molecular biology applications, including RNA labeling, probing, and therapeutic development.

CAT: BRP-00629

MF: C46H58N7O9P

MF: 883.98

Purity: ≥95%

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InChIKey: VAXVPZPBYJLJJN-NOYBBXANSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-ethoxy-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C46H58N7O9P/c1-10-58-40-39(62-63(60-26-14-25-47)53(30(4)5)31(6)7)37(61-44(40)52-28-48-38-41(52)49-45(51-43(38)55)50-42(54)29(2)3)27-59-46(32-15-12-11-13-16-32,33-17-21-35(56-8)22-18-33)34-19-23-36(57-9)24-20-34/h11-13,15-24,28-31,37,39-40,44H,10,14,26-27H2,1-9H3,(H2,49,50,51,54,55)/t37-,39-,40-,44-,63?/m1/s1

DMTr-2'-O-(Methyl behenate)-rC(Ac)-3'-CE-Phosphoramidite

Description: DMTr-2'-O-(Methyl behenate)-rC(Ac)-3'-CE-Phosphoramidite, employed in oligonucleotide synthesis, features a methyl behenate group at the 2'-O position, and an acetyl (Ac) protecting group on the cytosine amino group. The 3'-end is functionalized with a cyanoethyl (CE) group, facilitating efficient coupling reactions during solid-phase synthesis. It is used to introduce modified cytosine residues into nucleic acid sequences, enhancing stability and target specificity for applications such as RNA labeling, structural studies, and gene regulation research.

CAT: BRP-00630

MF: C64H94N5O11P

MF: 1140.45

Purity: ≥95%

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InChIKey: PKSNKLQRIFOCKB-QLODOALFSA-N

IUPAC Name: methyl 22-(((2R,3R,4R,5R)-2-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)tetrahydrofuran-3-yl)oxy)docosanoate

InChI: InChI=1S/C64H94N5O11P/c1-49(2)69(50(3)4)81(78-47-31-44-65)80-60-57(48-77-64(52-32-27-26-28-33-52,53-35-39-55(73-6)40-36-53)54-37-41-56(74-7)42-38-54)79-62(68-45-43-58(66-51(5)70)67-63(68)72)61(60)76-46-30-25-23-21-19-17-15-13-11-9-10-12-14-16-18-20-22-24-29-34-59(71)75-8/h26-28,32-33,35-43,45,49-50,57,60-62H,9-25,29-31,34,46-48H2,1-8H3,(H,66,67,70,72)/t57-,60-,61-,62-,81?/m1/s1

DMTr-2'-O-C22-rU-3'-CE-Phosphoramidite

Description: DMTr-2'-O-C22-rU-3'-CE-Phosphoramidite, utilized in oligonucleotide synthesis, contains a C22 group at the 2'-O position, and a uracil (rU) nucleoside. The 3'-end is functionalized with a cyanoethyl (CE) group, facilitating efficient coupling reactions during solid-phase synthesis. It is employed to introduce modified uracil residues with extended carbon chains into nucleic acid sequences, enhancing stability and target specificity for various molecular biology applications, including RNA structural studies, aptamer development, and gene regulation research.

CAT: BRP-00631

CAS: 2923115-86-8

MF: C61H91N4O9P

MF: 1055.39

Purity: ≥95%

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InChIKey: UVVBAOHROLTNIE-PGNDMMQRSA-N

CanonicalSMILES: CCCCCCCCCCCCCCCCCCCCCCOC1C(C(OC1N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(2,4-dioxopyrimidin-1-yl)-4-docosoxyoxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C61H91N4O9P/c1-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26-30-45-70-58-57(74-75(72-46-31-43-62)65(48(2)3)49(4)5)55(73-59(58)64-44-42-56(66)63-60(64)67)47-71-61(50-32-28-27-29-33-50,51-34-38-53(68-6)39-35-51)52-36-40-54(69-7)41-37-52/h27-29,32-42,44,48-49,55,57-59H,8-26,30-31,45-47H2,1-7H3,(H,63,66,67)/t55-,57-,58-,59-,75?/m1/s1

Synonyms: (2R,3R,4R,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-(docosyloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

DMTr-2'-O-C6-rU-3'-CE-Phosphoramidite

Description: DMTr-2'-O-C6-rU-3'-CE-Phosphoramidite is used in oligonucleotide synthesis and features a C6 group at the 2'-O position, and a uracil (rU) nucleoside. The 3'-end is functionalized with a cyanoethyl (CE) group, facilitating efficient coupling reactions during solid-phase synthesis. It is employed to introduce modified uracil residues with short carbon chains into nucleic acid sequences, enhancing stability and target specificity for applications such as RNA labeling, gene silencing, and aptamer development.

CAT: BRP-00632

CAS: 2382942-78-9

MF: C45H59N4O9P

MF: 830.96

Purity: ≥95%

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InChIKey: WMIJYXRHECYAIW-ACVVKSTRSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=CC(=O)NC2=O)C1OCCCCCC)COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-(hexyloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C45H59N4O9P/c1-8-9-10-14-29-54-42-41(58-59(56-30-15-27-46)49(32(2)3)33(4)5)39(57-43(42)48-28-26-40(50)47-44(48)51)31-55-45(34-16-12-11-13-17-34,35-18-22-37(52-6)23-19-35)36-20-24-38(53-7)25-21-36/h11-13,16-26,28,32-33,39,41-43H,8-10,14-15,29-31H2,1-7H3,(H,47,50,51)/t39-,41-,42-,43-,59?/m1/s1

Synonyms: 2'-O-hexyl U amidite; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-hexyl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

DMT-Hexylamine-linker Phosphoramidite

Description: DMT-Hexylamine-linker Phosphoramidite is utilized in oligonucleotide synthesis and contains a 4,4'-dimethoxytrityl (DMT) protecting group attached to a hexylamine linker via a phosphoramidite moiety. The hexylamine linker allows for the conjugation of oligonucleotides to various molecules, surfaces, or probes, facilitating applications such as nucleic acid labeling, immobilization, or conjugation to solid supports for affinity purification or detection purposes.

CAT: BRP-00633

CAS: 116919-15-4

MF: C36H50N3O4P

MF: 619.77

Purity: ≥95%

Appearance: Clear colorless to light yellow oily matter

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InChIKey: PFQIFKFFVAWUPT-UHFFFAOYSA-N

CanonicalSMILES: N#CCCOP(OCCCCCCNC(C=1C=CC=CC1)(C2=CC=C(OC)C=C2)C3=CC=C(OC)C=C3)N(C(C)C)C(C)C

IUPAC Name: 6-((bis(4-methoxyphenyl)(phenyl)methyl)amino)hexyl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C36H50N3O4P/c1-29(2)39(30(3)4)44(43-28-14-25-37)42-27-13-8-7-12-26-38-36(31-15-10-9-11-16-31,32-17-21-34(40-5)22-18-32)33-19-23-35(41-6)24-20-33/h9-11,15-24,29-30,38H,7-8,12-14,26-28H2,1-6H3

Synonyms: Phosphoramidous acid, N,N-bis(1-methylethyl)-, 6-[[bis(4-methoxyphenyl)phenylmethyl]amino]hexyl 2-cyanoethyl ester; Phosphoramidous acid, bis(1-methylethyl)-, 6-[[bis(4-methoxyphenyl)phenylmethyl]amino]hexyl 2-cyanoethyl ester; 6-[[Bis(4-methoxyphenyl)phenylmethyl]amino]hexyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite; 4,4'-Dimethoxytrityl-Hexylamine-Linker Cyanoethyl Phosphoramidite

DMTr-2'-O-(Methyl behenate)-rG(iBu)-3'-CE-Phosphoramidite

Description: DMTr-2'-O-(Methyl behenate)-rG(iBu)-3'-CE-Phosphoramidite, employed in oligonucleotide synthesis, features a methyl behenate group at the 2'-O position, and an isobutyryl (iBu) protecting group on the guanine amino group. The 3'-end is functionalized with a cyanoethyl (CE) group, facilitating efficient coupling reactions during solid-phase synthesis. It is used to introduce modified guanine residues into nucleic acid sequences, enhancing stability and target specificity for applications such as RNA labeling, structural studies, and gene regulation research.

CAT: BRP-00634

MF: C67H98N7O11P

MF: 1208.53

Purity: ≥95%

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InChIKey: VBNXQNNKVGWZHD-OMTARPPBSA-N

IUPAC Name: methyl 22-(((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-2-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl)oxy)docosanoate

InChI: InChI=1S/C67H98N7O11P/c1-49(2)63(76)71-66-70-62-59(64(77)72-66)69-48-73(62)65-61(81-45-31-26-24-22-20-18-16-14-12-10-11-13-15-17-19-21-23-25-30-35-58(75)80-9)60(85-86(83-46-32-44-68)74(50(3)4)51(5)6)57(84-65)47-82-67(52-33-28-27-29-34-52,53-36-40-55(78-7)41-37-53)54-38-42-56(79-8)43-39-54/h27-29,33-34,36-43,48-51,57,60-61,65H,10-26,30-32,35,45-47H2,1-9H3,(H2,70,71,72,76,77)/t57-,60-,61-,65-,86?/m1/s1

DMTr-2'-O-C22-rG(iBu)-3'-CE-Phosphoramidite

Description: DMTr-2'-O-C22-rG(iBu)-3'-CE-Phosphoramidite, utilized in oligonucleotide synthesis, contains a C22 group at the 2'-O position, and an isobutyryl (iBu) protecting group on the guanine amino group. The 3'-end is functionalized with a cyanoethyl (CE) group, facilitating efficient coupling reactions during solid-phase synthesis. It is employed to introduce modified guanine residues with extended carbon chains into nucleic acid sequences, enhancing stability and target specificity for various molecular biology applications, including RNA labeling, structural studies, and gene regulation research.

CAT: BRP-00635

CAS: 2923115-75-5

MF: C66H98N7O9P

MF: 1164.52

Purity: ≥95%

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InChIKey: MCJITTOIRVFXAC-JQGRTZKQSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C(=O)N=C(NC(=O)C(C)C)NC32)C1OCCCCCCCCCCCCCCCCCCCCCC)COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(docosyloxy)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C66H98N7O9P/c1-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26-27-28-32-45-78-60-59(82-83(80-46-33-44-67)73(50(4)5)51(6)7)57(81-64(60)72-48-68-58-61(72)69-65(71-63(58)75)70-62(74)49(2)3)47-79-66(52-34-30-29-31-35-52,53-36-40-55(76-8)41-37-53)54-38-42-56(77-9)43-39-54/h29-31,34-43,48-51,57,59-60,64H,10-28,32-33,45-47H2,1-9H3,(H2,69,70,71,74,75)/t57-,59-,60-,64-,83?/m1/s1

5'-O-DMT-3'-TBDMS-N4-Acetyl-cytidine 2'-CE phosphoramidite (BRP-00727)

Description: 5'-O-DMT-3'-TBDMS-N4-Acetyl-cytidine 2'-CE phosphoramidite, a revolutionary advancement in biomedicine, defies conventional limitations. Its profound significance lies in fostering a realm of intellectual exploration, propelling us towards unravelling the intricacies of modified oligonucleotides. This groundbreaking entity scrutinizes the enigma of drug delivery systems with unmatched precision, surmounting barriers that hinder the eradication of cancer, viral infections, and genetic disorders.

CAT: BRP-00727

MF: C47H64N5O9PSi

MF: 902.11

Purity: ≥97% by HPLC

Appearance: White to Off-white powder

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InChIKey: GNSFLPDFFNGTCR-YOEDQOPESA-N

Solubility: Soluble in Acetonitrile, DMF

IUPAC Name: (2R,3R,4R,5R)-2-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C47H64N5O9PSi/c1-32(2)52(33(3)4)62(58-30-16-28-48)60-43-42(61-63(11,12)46(6,7)8)40(59-44(43)51-29-27-41(49-34(5)53)50-45(51)54)31-57-47(35-17-14-13-15-18-35,36-19-23-38(55-9)24-20-36)37-21-25-39(56-10)26-22-37/h13-15,17-27,29,32-33,40,42-44H,16,30-31H2,1-12H3,(H,49,50,53,54)/t40-,42-,43-,44-,62?/m1/s1

Synonyms: 3'-TBDMS-Ac-rC Phosphoramidite; DMT-3'-O-TBDMS-C(Ac)-CE-Phosphoramidite; 3'-TBDMS-rC(Ac) phosphoramidite; 3'-OTBS C(Ac) 2'-amidite; 5'-O-DMT-N4-Acetyl-3'-O-tert-butyldimethylsilyl-cytidine 2'-CE phosphoramidite； Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 2'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; 3'-TBDMS-rC(Ac) phosphoramidite

TFA-6-amino-hexanol-DMT-2-methyl linker

Description: TFA-6-amino-hexanol-DMT-2-methyl linker is a specialized phosphoramidite compound used in oligonucleotide synthesis. It consists of a phosphoramidite moiety, which serves as a linker to attach nucleotide units during synthesis. Additionally, it contains a 2-methyl group and a 6-amino-hexanol-DMT protective group, along with a trifluoroacetyl (TFA) moiety. These modifications ensure stability during synthesis and enable precise control over the addition of nucleotide units, facilitating the creation of custom oligonucleotides for various molecular biology and biotechnology applications.

CAT: BRP-00728

MF: C39H51F3N3O6P

MF: 745.82

Purity: ≥97%

Appearance: Colorless oily liquid

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InChIKey: HRDZFZSXSXGZQJ-UHFFFAOYSA-N

CanonicalSMILES: CC(N(C(C)C)P(OCCC#N)OCC(CCCCNC(C(F)(F)F)=O)COC(C1=CC=C(OC)C=C1)(C2=CC=C(OC)C=C2)C3=CC=CC=C3)C

IUPAC Name: 2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-6-(2,2,2-trifluoroacetamido)hexyl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C39H51F3N3O6P/c1-29(2)45(30(3)4)52(50-26-12-24-43)51-28-31(13-10-11-25-44-37(46)39(40,41)42)27-49-38(32-14-8-7-9-15-32,33-16-20-35(47-5)21-17-33)34-18-22-36(48-6)23-19-34/h7-9,14-23,29-31H,10-13,25-28H2,1-6H3,(H,44,46)

Synonyms: TFA-6-amino-hexanol-DMT-2-methyl Phosphoramidite; TFA-6-amino-hexanol-DMT-2-methyl (2-cyanoethyl)-(N,N-diisopropyl)-Phosphoramidite; TFA-6-amino-hexanol-DMT-2-methyl

5-Me-DMT-2'-O-TBDMS-C(Ac)-CE-Phosphoramidite

Description: 5-Me-DMT-2'-O-TBDMS-C(Ac)-CE-Phosphoramidite is a modified nucleotide used in oligonucleotide synthesis. It features a Me group for the 5-position, a TBDMS group at the 2'-position of the ribose, and an acetyl (Ac) group on the cytosine base. The cyanoethyl (CE) group aids in coupling reactions during synthesis. This phosphoramidite facilitates precise modification of oligonucleotide sequences for various molecular biology applications.

CAT: BRP-00730

MF: C48H66N5O9PSi

MF: 916.14

Purity: ≥98%

Appearance: White to Off-white powder

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InChIKey: RZBVVWCKSUSNLP-KDDRLGGRSA-N

IUPAC Name: (2R,3R,4R,5R)-5-(4-acetamido-5-methyl-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C48H66N5O9PSi/c1-32(2)53(33(3)4)63(59-29-17-28-49)61-42-41(60-45(43(42)62-64(12,13)47(7,8)9)52-30-34(5)44(50-35(6)54)51-46(52)55)31-58-48(36-18-15-14-16-19-36,37-20-24-39(56-10)25-21-37)38-22-26-40(57-11)27-23-38/h14-16,18-27,30,32-33,41-43,45H,17,29,31H2,1-13H3,(H,50,51,54,55)/t41-,42-,43-,45-,63?/m1/s1

Synonyms: N4-Acetyl-5-methyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-TBDMS-cytidine-3'-cyanoethyl phosphoramidite; 2'-OTBDMS-5-Me-C-CE Phosphoramidite; 5'-Dimethoxytrityl-N-acetyl-5-methyl-Cytidine, 2'-O-[(1,1-dimethylethyl)dimethylsilyl], 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-5-methyl-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; 5'-O-DMTr-2'-O-TBDMS-5-Me-C(Ac)-3'-CE-Phosphoramidite; N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyl-dimethylsilyl)-5-methyl-cytidine-3'-cyanoethyl Phosphoramidite

1-Fmoc-12-amino-hexane-DMT-2-methyl phosphoramidite

Description: 1-Fmoc-12-amino-hexane-DMT-2-methyl phosphoramidite is a modified phosphoramidite used in solid-phase peptide synthesis (SPPS). It contains an Fmoc-protected amino acid with a 12-amino-hexane linker attached to it, along with a 2-methyl group on the phosphoramidite moiety. This compound facilitates the stepwise assembly of peptides on a solid support in peptide synthesis.

CAT: BRP-00731

MF: C63H83N4O12P

MF: 1119.35

Purity: ≥95%

Appearance: Colorless oily liquid

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InChIKey: YEIRUDIFMAGFEP-UHFFFAOYSA-N

CanonicalSMILES: CC(N(C(C)C)P(OCC(COC(C1=CC=C(OC)C=C1)(C2=CC=C(OC)C=C2)C3=CC=CC=C3)CCCCNC(CCOCCOCCOCCOCCNC(OCC4C5=C(C=CC=C5)C6=C4C=CC=C6)=O)=O)OCCC#N)C

IUPAC Name: (9H-fluoren-9-yl)methyl (4-((((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)methyl)-1,1-bis(4-methoxyphenyl)-10-oxo-1-phenyl-2,13,16,19,22-pentaoxa-9-azatetracosan-24-yl)carbamate

InChI: InChI=1S/C63H83N4O12P/c1-48(2)67(49(3)4)80(78-36-16-33-64)79-46-50(45-77-63(51-18-8-7-9-19-51,52-24-28-54(70-5)29-25-52)53-26-30-55(71-6)31-27-53)17-14-15-34-65-61(68)32-37-72-39-41-74-43-44-75-42-40-73-38-35-66-62(69)76-47-60-58-22-12-10-20-56(58)57-21-11-13-23-59(57)60/h7-13,18-31,48-50,60H,14-17,32,34-47H2,1-6H3,(H,65,68)(H,66,69)

Synonyms: 1-Fmoc-12-amino-hexane-DMT-2-methyl amidite

Fmoc-6-amino-hexanol-DMT-2-methyl linker

Description: Fmoc-6-amino-hexanol-DMT-2-methyl linker is a component utilized in solid-phase peptide synthesis (SPPS). It consists of an Fmoc-protected amino alcohol with a 6-amino-hexanol linker, along with a 2-methyl group on the phosphoramidite moiety. This linker is employed in peptide synthesis for introducing amino acids onto a solid support.

CAT: BRP-00732

CAS: 147190-40-7

MF: C52H62N3O7P

MF: 872.06

Purity: ≥97%

Appearance: Colorless oily liquid

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InChIKey: GLNANYHDNPKVLL-UHFFFAOYSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OCC(CCCCNC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: 9H-fluoren-9-ylmethyl N-[5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-6-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyhexyl]carbamate

InChI: InChI=1S/C52H62N3O7P/c1-38(2)55(39(3)4)63(61-34-16-32-53)62-36-40(17-14-15-33-54-51(56)59-37-50-48-22-12-10-20-46(48)47-21-11-13-23-49(47)50)35-60-52(41-18-8-7-9-19-41,42-24-28-44(57-5)29-25-42)43-26-30-45(58-6)31-27-43/h7-13,18-31,38-40,50H,14-17,33-37H2,1-6H3,(H,54,56)

Synonyms: Fmoc-6-amino-hexanol-DMT-2-methyl Phosphoramidite; Fmoc-6-amino-hexanol-DMT-2-methyl-(2-cyanoethyl)-(N,N-diisopropyl)-Phosphoramidite; 9,11-Dioxa-2-aza-10-phosphatridecanoic acid, 7-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-10-[bis(1-methylethyl)amino]-13-cyano-, 9H-fluoren-9-ylmethyl ester; N-Fmoc-C6-2-(DMTmethoxyl)-aminelinker Phosphoramidite; (9H-fluoren-9-yl)methyl (6-(bis(4-methoxyphenyl)(phenyl)methoxy)-5-((((2-cyanoethoxy)(diisopropylamino)phosphanyl)oxy)methyl)hexyl)carbamate

S-cEt-C phosphoramidite

Description: S-cEt-C phosphoramidite is a specialized reagent used in the chemical synthesis of modified oligonucleotides. This compound features a cytosine (C) base that is methylated at the 5th position (5-Me), with an N4-benzoyl (N-Bz) protecting group and a constrained ethyl (cEt) modification. Additionally, it has a 5'-O-(4,4'-dimethoxytrityl) (ODMT) protective group. The constrained ethyl (cEt) modification enhances the stability and binding affinity of the resulting oligonucleotide, increasing resistance to nuclease degradation and improving hybridization properties. 5'-ODMT cEt N-Bz 5-Me C Phosphoramidite (Amidite) is an essential reagent for synthesizing modified oligonucleotides, offering enhanced stability, binding affinity, and resistance to degradation, which is particularly useful in advanced nucleic acid-based therapeutics and research.

CAT: BRP-00733

CAS: 1197033-17-2

MF: C49H56N5O9P

MF: 889.99

Purity: 98%

Appearance: White to off-white solid

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InChIKey: BDTXILPCBUAYPJ-USFFSJIASA-N

Solubility: Soluble in DMSO

CanonicalSMILES: CC1C2(C(C(O1)C(O2)N3C=C(C(=NC3=O)NC(=O)C4=CC=CC=C4)C)OP(N(C(C)C)C(C)C)OCCC#N)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC

IUPAC Name: N-[1-[(1S,3R,4R,6S,7S)-1-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-7-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-6-methyl-2,5-dioxabicyclo[2.2.1]heptan-3-yl]-5-methyl-2-oxopyrimidin-4-yl]benzamide

InChI: InChI=1S/C49H56N5O9P/c1-32(2)54(33(3)4)64(60-29-15-28-50)63-43-42-46(53-30-34(5)44(52-47(53)56)51-45(55)36-16-11-9-12-17-36)62-48(43,35(6)61-42)31-59-49(37-18-13-10-14-19-37,38-20-24-40(57-7)25-21-38)39-22-26-41(58-8)27-23-39/h9-14,16-27,30,32-33,35,42-43,46H,15,29,31H2,1-8H3,(H,51,52,55,56)/t35-,42+,43-,46+,48-,64?/m0/s1

Synonyms: 5'-ODMT cEt N-Bzm5 C Phosphoramidite (Amidite); N-[1-[2,5-Anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-6-deoxy-α-L-mannofuranosyl]-1,2-dihydro-5-methyl-2-oxo-4-pyrimidinyl]benzamide; (1S,3R,4R,6S,7S)-3-(4-benzamido-5-methyl-2-oxopyrimidin-1(2H)-yl)-1-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-6-methyl-2,5-dioxabicyclo[2.2.1]heptan-7-yl 2-cyanoethyl diisopropylphosphoramidite; 5'-ODMT cEt N-Bz 5-Me C Phosphoramidite; 5'-O-DMTr-cEt-BNA-N-Bz-Me-Cytidine-CEP; CET-5-Me-C(Bz) Phosphoramidite