Nucleosides

3'-O-TBDMS-2'-F-dA(Bz)

Description: 3'-O-TBDMS-2'-F-dA(Bz) is a chemically modified nucleoside used in nucleic acid research and synthesis. This modification is employed to study nucleotide interactions, stability, and potential therapeutic applications by altering the chemical and biological properties of the nucleoside.

CAT: BRP-01534

CAS: 1244763-25-4

Molecular Formula: C23H30FN5O4Si

Molecular Weight: 487.61

Purity: ≥98% by HPLC

Appearance: White to light yellow powder

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Storage: Store at 2-8 °C

Density: 1.32±0.1 g/cm3

InChIKey: VTZHRUXQJMHXQW-RPLGYBLPSA-N

CanonicalSMILES: O=C(NC1=NC=NC2=C1N=CN2C3OC(CO)C(O[Si](C)(C)C(C)(C)C)C3F)C=4C=CC=CC4

IUPAC Name: N-(9-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-3-fluoro-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide

InChI: InChI=1S/C23H30FN5O4Si/c1-23(2,3)34(4,5)33-18-15(11-30)32-22(16(18)24)29-13-27-17-19(25-12-26-20(17)29)28-21(31)14-9-7-6-8-10-14/h6-10,12-13,15-16,18,22,30H,11H2,1-5H3,(H,25,26,28,31)/t15-,16-,18-,22-/m1/s1

Synonyms: Adenosine, N-benzoyl-2'-deoxy-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-2'-fluoro-; N-Benzoyl-2'-deoxy-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-2'-fluoroadenosine; N6-benzoyl-3'-O-(t-butyl-dimethylsilyl)-2'-fluorine-2'-deoxyadenosine; N-(9-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-3-fluoro-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide

3'-O-TBDMS-2'-F-dG(iBu)

Description: 3'-O-TBDMS-2'-F-dG(iBu) is a chemically modified nucleoside used in biochemical and pharmaceutical research. This compound is designed to alter the properties of guanosine for specific applications, such as enhancing stability, modifying base-pairing interactions, or studying enzymatic reactions involving guanine derivatives.

CAT: BRP-01535

CAS: 2382967-92-0

Molecular Formula: C20H32FN5O5Si

Molecular Weight: 469.59

Purity: ≥98% by HPLC

Appearance: White to off-white powder

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Storage: Store at 2-8 °C

Density: 1.36±0.1 g/cm3

InChIKey: ACBLMVCONMEAIO-LZDVPDMXSA-N

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)CO)O[Si](C)(C)C(C)(C)C)F

IUPAC Name: N-[9-[(2R,3R,4R,5R)-4-[tert-butyl(dimethyl)silyl]oxy-3-fluoro-5-(hydroxymethyl)oxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide

InChI: InChI=1S/C20H32FN5O5Si/c1-10(2)16(28)24-19-23-15-13(17(29)25-19)22-9-26(15)18-12(21)14(11(8-27)30-18)31-32(6,7)20(3,4)5/h9-12,14,18,27H,8H2,1-7H3,(H2,23,24,25,28,29)/t11-,12-,14-,18-/m1/s1

Synonyms: 2'-F-3'-TBS-iBu-dG; N2-isobutyryl-3'-O-(t-butyl-dimethylsilyl)-2'-fluorine-2'-deoxyguanosine; Guanosine, 2'-deoxy-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-2'-fluoro-N-(2-methyl-1-oxopropyl)-; N-(9-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-3-fluoro-5-(hydroxymethyl)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide

5'-O-DMT-N4-Acetyl-2'-fluoro-5-methyl-2'-deoxycytidine

Description: 5'-O-DMT-N4-acetyl-2'-Fluoro-5-methyl-2'-deoxycytidine is a chemically modified nucleoside used in the synthesis of oligonucleotides to enhance their stability, specificity, and resistance to enzymatic degradation, making it valuable for developing therapeutic agents, such as antisense oligonucleotides and siRNAs, and for studying nucleic acid interactions and enzymatic processes in research.

CAT: BRP-01541

Molecular Formula: C33H34FN3O7

Molecular Weight: 603.65

Purity: >98%

Appearance: White to light yellow powder

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InChIKey: STUFCHVUNHNWMI-BUVRPPHQSA-N

IUPAC Name: N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-fluoro-4-hydroxyoxolan-2-yl]-5-methyl-2-oxopyrimidin-4-yl]acetamide

InChI: InChI=1S/C33H34FN3O7/c1-20-18-37(32(40)36-30(20)35-21(2)38)31-28(34)29(39)27(44-31)19-43-33(22-8-6-5-7-9-22,23-10-14-25(41-3)15-11-23)24-12-16-26(42-4)17-13-24/h5-18,27-29,31,39H,19H2,1-4H3,(H,35,36,38,40)/t27-,28-,29-,31-/m1/s1

Synonyms: N-(1-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)-5-methyl-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide; 5'-O-DMT-N4-Acetyl-2'-Fluoro-5-methyl-2'-deoxycytidine; N4-Acetyl-5'-O-DMT-2'-fluoro-5-methyl-2'-deoxycytidine; N-Acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-5-methylcytidine; 5'-O-DMT-2'-F-5-Me-dC(Ac); N4-Acetyl-2'-deoxy-5'-O-DMT-2'-fluoro-5-methylcytidine

N4-Acetyl-5-Iodo-2'-fluoro-2'-deoxycytidine

Description: N4-Acetyl-5-Iodo-2'-fluoro-2'-deoxycytidine is a chemically modified nucleoside used in oligonucleotide synthesis to enhance stability and resistance to enzymatic degradation due to its 2'-fluoro modification. The 5-iodo group allows for labeling and detection in various assays, while the N4-acetyl group protects the nucleobase during synthesis. This modified nucleoside is valuable for developing stable and specific therapeutic oligonucleotides, such as antisense oligonucleotides and siRNAs, and is also useful in research to study nucleic acid interactions and enzymatic processes.

CAT: BRP-01547

CAS: 2940869-29-2

Molecular Formula: C11H13FIN3O5

Molecular Weight: 413.14

Purity: ≥95%

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Density: 2.19±0.1 g/cm3

InChIKey: KDMMJHWZVCPNLN-FDDDBJFASA-N

CanonicalSMILES: CC(=O)NC1=NC(=O)N(C=C1I)C2C(C(C(O2)CO)O)F

IUPAC Name: N-[1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodo-2-oxopyrimidin-4-yl]acetamide

InChI: InChI=1S/C11H13FIN3O5/c1-4(18)14-9-5(13)2-16(11(20)15-9)10-7(12)8(19)6(3-17)21-10/h2,6-8,10,17,19H,3H2,1H3,(H,14,15,18,20)/t6-,7-,8-,10-/m1/s1

Synonyms: N4-Ac-5-I-2'-F-dC; N4-Ac-5-iodo-2'-fluoro-2'-dC

5'-O-(4,4'-Dimethoxytrityl)-N2-dimethylformamidine-2'-fluoro-2'-deoxyguanosine

Description: 5'-O-(4,4'-Dimethoxytrityl)-N2-dimethylformamidine-2'-fluoro-2'-deoxyguanosine is a chemically modified nucleoside used in oligonucleotide synthesis. This nucleoside features a 5'-O-(4,4'-Dimethoxytrityl) protecting group on the 5' hydroxyl, a N2-dimethylformamidine group at the guanosine base, and a 2'-fluoro modification on the deoxyribose sugar. It is employed to enhance stability and specificity in oligonucleotide design, particularly useful for developing therapeutic oligonucleotides like antisense oligonucleotides and siRNAs, and for conducting research on nucleic acid interactions and structure-function relationships.

CAT: BRP-01548

CAS: 2377586-41-7

Molecular Formula: C34H35FN6O6

Molecular Weight: 642.68

Purity: ≥98% by HPLC

Appearance: White powder

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Storage: Store at 2-8 °C, Keep in a dark and dry place

Density: 1.35±0.1 g/cm3

Boiling Point: 839.5±75.0 °C at 760 mmHg

InChIKey: YYXHJLCVHPOJDK-UUEOAETPSA-N

CanonicalSMILES: CN(C)C=NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)O)F

IUPAC Name: N'-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-fluoro-4-hydroxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]-N,N-dimethylmethanimidamide

InChI: InChI=1S/C34H35FN6O6/c1-40(2)19-37-33-38-30-28(31(43)39-33)36-20-41(30)32-27(35)29(42)26(47-32)18-46-34(21-8-6-5-7-9-21,22-10-14-24(44-3)15-11-22)23-12-16-25(45-4)17-13-23/h5-17,19-20,26-27,29,32,42H,18H2,1-4H3,(H,38,39,43)/t26-,27-,29-,32-/m1/s1

Synonyms: N2-dmf-DMT-2'-F-dG; 5'-O-DMT-N2-dimethylformamide-2'-fluoro-2'-deoxyguanosine; 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-N-[(dimethylamino)methylene]guanosine; N'-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethylformimidamide

N1-Methylene pivalate-N2-dibutylformamidine-2'-fluoro-guanosine

Description: N1-Methylene pivalate-N2-dibutylformamidine-2'-fluoro-guanosine is a modified guanosine nucleoside designed with protective groups at the N1 and N2 positions, alongside a 2'-fluoro modification on the ribose, enhancing stability and resistance to enzymatic degradation. This compound is pivotal in synthesizing modified oligonucleotides for biomedical research, improving nucleic acid performance in applications like gene therapy and molecular diagnostics.

CAT: BRP-01563

Molecular Formula: C25H39FN6O6

Molecular Weight: 538.62

Purity: ≥95% by HPLC

Appearance: White powder

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Storage: Store at 2-8 °C, Keep in a dark and dry place

InChIKey: OSNSETGWWMLVPD-VALFRTSSSA-N

IUPAC Name: (2-(((dibutylamino)methylene)amino)-9-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-1-yl)methyl pivalate

InChI: InChI=1S/C25H39FN6O6/c1-6-8-10-30(11-9-7-2)13-28-24-29-20-18(21(35)32(24)15-37-23(36)25(3,4)5)27-14-31(20)22-17(26)19(34)16(12-33)38-22/h13-14,16-17,19,22,33-34H,6-12,15H2,1-5H3/t16-,17-,19-,22-/m1/s1

Synonyms: N1-methylene pivalate-N2-dibutylformamidine-2'-F-Gr

N4-Dibutylformamidine-2'-fluoro-deoxycytidine

Description: N4-Dibutylformamidine-2'-fluoro-deoxycytidine is a modified deoxycytidine nucleoside featuring a dibutylformamidine group at the N4 position and a 2'-fluoro modification on the deoxyribose sugar, enhancing stability and enzymatic resistance in oligonucleotide synthesis, crucial for biomedical applications like gene therapy and molecular diagnostics.

CAT: BRP-01564

Molecular Formula: C18H29FN4O4

Molecular Weight: 384.45

Purity: ≥95% by HPLC

Appearance: White powder

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Storage: Store at 2-8 °C, Keep in a dark and dry place

InChIKey: LALGLRQWGPDIIJ-MWQQHZPXSA-N

IUPAC Name: N,N-dibutyl-N'-(1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)formimidamide

InChI: InChI=1S/C18H29FN4O4/c1-3-5-8-22(9-6-4-2)12-20-14-7-10-23(18(26)21-14)17-15(19)16(25)13(11-24)27-17/h7,10,12-13,15-17,24-25H,3-6,8-9,11H2,1-2H3/t13-,15-,16-,17-/m1/s1

Synonyms: N4-dibutylformamidine-2'-F-dC

N2-Dibutylformamidine-2'-fluoro-guanosine

Description: N2-Dibutylformamidine-2'-fluoro-guanosine is a modified guanosine nucleoside with a dibutylformamidine group attached to the N2 position and a 2'-fluoro modification on the ribose, enhancing stability and enzymatic resistance in oligonucleotide synthesis, crucial for biomedical applications like gene therapy and molecular diagnostics.

CAT: BRP-01565

Molecular Formula: C19H29FN6O4

Molecular Weight: 424.48

Purity: ≥95% by HPLC

Appearance: White powder

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Storage: Store at 2-8 °C, Keep in a dark and dry place

InChIKey: XMWCLGNFTGLYEX-HOPMXRPOSA-N

IUPAC Name: N,N-dibutyl-N'-(9-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)formimidamide

InChI: InChI=1S/C19H29FN6O4/c1-3-5-7-25(8-6-4-2)10-22-19-23-16-14(17(29)24-19)21-11-26(16)18-13(20)15(28)12(9-27)30-18/h10-13,15,18,27-28H,3-9H2,1-2H3,(H,23,24,29)/t12-,13-,15-,18-/m1/s1

Synonyms: N2-dibutylformamidine-2'-F-Gr

N2-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-deoxyguanosine

Description: N2-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-deoxyguanosine is a modified deoxyguanosine nucleoside with an acetyl group at the N2 position and a 2'-fluoro modification on the deoxyribose sugar, protected by a 4,4'-dimethoxytrityl (DMTr) group at the 5'-hydroxyl. This modification enhances stability and enzymatic resistance in oligonucleotide synthesis, essential for biomedical applications such as gene therapy and molecular diagnostics.

CAT: BRP-01566

CAS: 514830-14-9

Molecular Formula: C33H32FN5O7

Molecular Weight: 629.63

Purity: ≥95% by HPLC

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Storage: Store at 2-8 °C, Keep in a dark and dry place

InChIKey: JKJYAEOBEUHFSL-IAHIMPAPSA-N

CanonicalSMILES: CC(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)O)F

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-fluoro-4-hydroxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]acetamide

InChI: InChI=1S/C33H32FN5O7/c1-19(40)36-32-37-29-27(30(42)38-32)35-18-39(29)31-26(34)28(41)25(46-31)17-45-33(20-7-5-4-6-8-20,21-9-13-23(43-2)14-10-21)22-11-15-24(44-3)16-12-22/h4-16,18,25-26,28,31,41H,17H2,1-3H3,(H2,36,37,38,40,42)/t25-,26-,28-,31-/m1/s1

Synonyms: N2-Ac-DMT-2'-F-dG; N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)acetamide; Guanosine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-; N-Acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoroguanosine

N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-3'-O-succinate-2'-fluoro-deoxyguanosine, triethylamine salt

Description: N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-3'-O-succinate-2'-fluoro-deoxyguanosine, triethylamine salt is a modified deoxyguanosine nucleoside. It features an isobutyryl group at the N2 position, a 4,4'-dimethoxytrityl (DMTr) group at the 5'-hydroxyl, a succinate ester at the 3'-hydroxyl, and a 2'-fluoro modification on the deoxyribose sugar. This compound, in its triethylamine salt form, enhances stability and enzymatic resistance in oligonucleotide synthesis, crucial for applications such as gene therapy and molecular diagnostics.

CAT: BRP-01572

Molecular Formula: C45H55FN6O10

Molecular Weight: 858.95

Purity: ≥98% by HPLC

Appearance: White to off-white powder

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Storage: Store at RT

InChIKey: JAFGAGVWXBMKKQ-KYJIEUEGSA-N

CanonicalSMILES: O=C1N=C(NC(=O)C(C)C)NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(OC(=O)CCC(=O)O)C3F.N(CC)(CC)CC

IUPAC Name: 4-(((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl)oxy)-4-oxobutanoic acid;N,N-diethylethanamine

InChI: InChI=1S/C39H40FN5O10.C6H15N/c1-22(2)35(49)43-38-42-34-32(36(50)44-38)41-21-45(34)37-31(40)33(55-30(48)19-18-29(46)47)28(54-37)20-53-39(23-8-6-5-7-9-23,24-10-14-26(51-3)15-11-24)25-12-16-27(52-4)17-13-25;1-4-7(5-2)6-3/h5-17,21-22,28,31,33,37H,18-20H2,1-4H3,(H,46,47)(H2,42,43,44,49,50);4-6H2,1-3H3/t28-,31-,33-,37-;/m1./s1

Synonyms: N2-iBu-DMT-2'-F-dG-3'-succinate, TEA salt; 5'-DMT-2'-F-dG(iBu)-3'-succinate, TEA salt; 5'-DMT-NIBu-2'-F-dG-3'-succinate, TEA salt; 5'-O-(4,4'-Dimethoxytrityl)-N2-isobutyryl-2'-fluoro-deoxyguanosine-3'-O-succinate, triethylamine salt

N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-3'-O-succinate-2'-fluoro-deoxyadenosine, triethylamine salt

Description: N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-3'-O-succinate-2'-fluoro-deoxyadenosine, triethylamine salt is a modified deoxyadenosine nucleoside. It features a benzoyl group at the N6 position, a 4,4'-dimethoxytrityl (DMTr) group at the 5'-hydroxyl, a succinate ester at the 3'-hydroxyl, and a 2'-fluoro modification on the deoxyribose sugar. This compound, in its triethylamine salt form, enhances stability and enzymatic resistance in oligonucleotide synthesis, crucial for applications such as gene therapy and molecular diagnostics.

CAT: BRP-01573

Molecular Formula: C48H53FN6O9

Molecular Weight: 876.97

Purity: ≥98% by HPLC

Appearance: White to yellow powder

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Storage: Store at 2-8 °C

InChIKey: RVRGUAZPBXTGSP-ARCYALSHSA-N

CanonicalSMILES: O=C(O)CCC(=O)OC1C(F)C(OC1COC(C=2C=CC=CC2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)N5C=NC=6C(=NC=NC65)NC(=O)C=7C=CC=CC7.N(CC)(CC)CC

IUPAC Name: 4-(((2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl)oxy)-4-oxobutanoic acid;N,N-diethylethanamine

InChI: InChI=1S/C42H38FN5O9.C6H15N/c1-53-30-17-13-28(14-18-30)42(27-11-7-4-8-12-27,29-15-19-31(54-2)20-16-29)55-23-32-37(57-34(51)22-21-33(49)50)35(43)41(56-32)48-25-46-36-38(44-24-45-39(36)48)47-40(52)26-9-5-3-6-10-26;1-4-7(5-2)6-3/h3-20,24-25,32,35,37,41H,21-23H2,1-2H3,(H,49,50)(H,44,45,47,52);4-6H2,1-3H3/t32-,35-,37-,41-;/m1./s1

Synonyms: N6-Bz-DMT-2'-F-dA-3'-succinate, TEA salt; 5'-O-(4,4'-Dimethoxytrityl)-N6-benzoyl-2'-deoxyadenoisne-3'-O-succinate, triethylamine salt; 5'-DMT-NBz-2'-dA-3'-succinate, TEA salt

N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-3'-O-succinate-2'-fluoro-deoxycytidine, triethylamine salt

Description: N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-3'-O-succinate-2'-fluoro-deoxycytidine, triethylamine salt is a modified deoxycytidine nucleoside. It features an acetyl group at the N4 position, a 4,4'-dimethoxytrityl (DMTr) group at the 5'-hydroxyl, a succinate ester at the 3'-hydroxyl, and a 2'-fluoro modification on the deoxyribose sugar. This compound, in its triethylamine salt form, enhances stability and enzymatic resistance in oligonucleotide synthesis, crucial for applications such as gene therapy and molecular diagnostics.

CAT: BRP-01574

Molecular Formula: C42H51FN4O10

Molecular Weight: 790.87

Purity: ≥98% by HPLC

Appearance: White to yellow powder

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Storage: Store at 2-8 °C

InChIKey: GGLFHSJASYEZGI-PBJRKIRISA-N

CanonicalSMILES: CCN(CC)CC.CC(=O)NC1=NC(=O)N(C=C1)C2C(C(C(O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OC(=O)CCC(=O)O)F

IUPAC Name: 4-[(2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1-yl)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-fluorooxolan-3-yl]oxy-4-oxobutanoic acid;N,N-diethylethanamine

InChI: InChI=1S/C36H36FN3O10.C6H15N/c1-22(41)38-29-19-20-40(35(45)39-29)34-32(37)33(50-31(44)18-17-30(42)43)28(49-34)21-48-36(23-7-5-4-6-8-23,24-9-13-26(46-2)14-10-24)25-11-15-27(47-3)16-12-25;1-4-7(5-2)6-3/h4-16,19-20,28,32-34H,17-18,21H2,1-3H3,(H,42,43)(H,38,39,41,45);4-6H2,1-3H3/t28-,32-,33-,34-;/m1./s1

Synonyms: N4-Ac-DMT-2'-F-dC-3'-succinate, TEA salt; 5'-O-(4,4'-Dimethoxytrityl)-N4-acetyl-3'-O-succinate-2'-fluoro-deoxycytidine, triethylamine salt; 5'-DMT-N4-Ac-2'-F-dC-3'-succinate, TEA salt; Triethylamine 4-(((2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl)oxy)-4-oxobutanoate

Related CAS: 2746380-45-8 (free base)

5'-O-DMT-3'-O-succinate-2'-F-deoxyuridine, triethylamine salt

Description: 5'-O-DMT-3'-O-succinate-2'-F-deoxyuridine, triethylamine salt is a modified deoxyuridine nucleoside. It features a 5'-dimethoxytrityl (DMT) group at the 5'-hydroxyl, a succinate ester at the 3'-hydroxyl, and a fluorine atom (2'-F) modification on the deoxyribose sugar. This compound, in its triethylamine salt form, enhances stability and enzymatic resistance in oligonucleotide synthesis, making it valuable for applications such as gene therapy and molecular diagnostics.

CAT: BRP-01575

CAS: 2294880-79-6

Molecular Formula: C40H48FN3O10

Molecular Weight: 749.82

Purity: ≥98% by HPLC

Appearance: White to yellow powder

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Storage: Store at 2-8 °C

InChIKey: ZLUXDOSHTOAICW-GNGCXMSBSA-N

CanonicalSMILES: CCN(CC)CC.COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)OCC4C(C(C(O4)N5C=CC(=O)NC5=O)F)OC(=O)CCC(=O)O

IUPAC Name: 4-[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(2,4-dioxopyrimidin-1-yl)-4-fluorooxolan-3-yl]oxy-4-oxobutanoic acid;N,N-diethylethanamine

InChI: InChI=1S/C34H33FN2O10.C6H15N/c1-43-24-12-8-22(9-13-24)34(21-6-4-3-5-7-21,23-10-14-25(44-2)15-11-23)45-20-26-31(47-29(41)17-16-28(39)40)30(35)32(46-26)37-19-18-27(38)36-33(37)42;1-4-7(5-2)6-3/h3-15,18-19,26,30-32H,16-17,20H2,1-2H3,(H,39,40)(H,36,38,42);4-6H2,1-3H3/t26-,30-,31-,32-;/m1./s1

Synonyms: DMT-2'-F-dU-3'-succinate, TEA salt; 5'-O-(4,4'-dimethoxytrityl)-3'-O-succinate-2'-fluoro-deoxyuridine, triethylamine salt; Triethylamine 4-(((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluorotetrahydrofuran-3-yl)oxy)-4-oxobutanoate; 5'-O-(4,4'-Dimethoxytrityl)-2'-fluoro-deoxyuridine 3'-O-succinate, triethylamine salt; 5'-DMT-2'-F-dU-3'-succinate, TEA salt

Related CAS: 2294880-67-2 (free base)

1-(2-Fluoro-2-deoxy-β-L-arabinofuranosyl)cytosine

Description: 1-(2-Fluoro-2-deoxy-β-L-arabinofuranosyl)cytosine is a modified nucleoside where cytosine is attached to a β-L-arabinofuranosyl sugar with a 2-fluoro-2-deoxy modification. This modification enhances the stability and alters the chemical properties of the nucleoside, making it useful in nucleic acid chemistry for applications such as nucleotide analog synthesis and structural studies.

CAT: BRP-01592

CAS: 163686-35-9

Molecular Formula: C9H12FN3O4

Molecular Weight: 245.21

Purity: ≥98%

Appearance: White to off-white powder

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Density: 1.82±0.1 g/cm3

Boiling Point: 500.1±60.0 °C at 760 mmHg

InChIKey: NVZFZMCNALTPBY-UCVXFZOQSA-N

CanonicalSMILES: C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)F

IUPAC Name: 4-amino-1-[(2S,3R,4S,5S)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one

InChI: InChI=1S/C9H12FN3O4/c10-6-7(15)4(3-14)17-8(6)13-2-1-5(11)12-9(13)16/h1-2,4,6-8,14-15H,3H2,(H2,11,12,16)/t4-,6+,7-,8-/m0/s1

Synonyms: 2(1H)-Pyrimidinone, 4-amino-1-(2-deoxy-2-fluoro-β-L-arabinofuranosyl)-; L-2'-F-Ara-Cytidine; 1-(2-Deoxy-2-fluoro-beta-L-arabinofuranosyl) cytosine; 4-amino-1-((2S,3R,4S,5S)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one; 4-Amino-1-(2-deoxy-2-fluoro-β-L-arabinofuranosyl)-2(1H)-pyrimidinone

9-(2'-Fluoro-2'-deoxy-β-L-arabinofuranosyl)adenine

Description: 9-(2'-Fluoro-2'-deoxy-β-L-arabinofuranosyl)adenine is a modified nucleoside where adenine is attached to a β-L-arabinofuranosyl sugar with a 2'-fluoro-2'-deoxy modification at the ribose. This modification enhances the stability and alters the chemical properties of the nucleoside, making it useful in nucleic acid chemistry for applications such as nucleotide analog synthesis and structural studies.

CAT: BRP-01593

CAS: 193754-07-3

Molecular Formula: C10H12FN5O3

Molecular Weight: 269.23

Purity: ≥98%

Appearance: White to off-white powder

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Density: 2.01±0.1 g/cm3

Boiling Point: 628.6±65.0 °C at 760 mmHg

InChIKey: ZGYYPTJWJBEXBC-JZWIFLOVSA-N

CanonicalSMILES: C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)CO)O)F)N

IUPAC Name: (2S,3S,4R,5S)-5-(6-aminopurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol

InChI: InChI=1S/C10H12FN5O3/c11-5-7(18)4(1-17)19-10(5)16-3-15-6-8(12)13-2-14-9(6)16/h2-5,7,10,17-18H,1H2,(H2,12,13,14)/t4-,5+,7-,10-/m0/s1

Synonyms: L-2'-F-Ara-Adenosine; 9-(2-Deoxy-2-fluoro-beta-L-arabinofuranosyl)adenine; (2S,3S,4R,5S)-5-(6-aminopurin-9-yl)-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-ol; 9-(2-Deoxy-2-fluoro-β-L-arabinofuranosyl)-9H-purin-6-amine; 9H-Purin-6-amine, 9-(2-deoxy-2-fluoro-β-L-arabinofuranosyl)-

9-(2-Deoxy-2-fluoro-β-L-arabinofuranosyl)guanine

Description: 9-(2-Deoxy-2-fluoro-β-L-arabinofuranosyl)guanine is a modified nucleoside where guanine is attached to a β-L-arabinofuranosyl sugar with a 2-deoxy-2-fluoro modification. This modification enhances the stability and alters the chemical properties of the nucleoside, making it useful in nucleic acid chemistry for applications such as nucleotide analog synthesis and structural studies.

CAT: BRP-01594

CAS: 193754-19-7

Molecular Formula: C10H12FN5O4

Molecular Weight: 285.23

Purity: ≥98%

Appearance: White to off-white powder

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Density: 2.17±0.1 g/cm3

Boiling Point: 726.1±70.0 °C at 760 mmHg

InChIKey: UXUZARPLRQRNNX-LSSUFRDISA-N

CanonicalSMILES: C1=NC2=C(N1C3C(C(C(O3)CO)O)F)N=C(NC2=O)N

IUPAC Name: 2-amino-9-[(2S,3R,4S,5S)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-6-one

InChI: InChI=1S/C10H12FN5O4/c11-4-6(18)3(1-17)20-9(4)16-2-13-5-7(16)14-10(12)15-8(5)19/h2-4,6,9,17-18H,1H2,(H3,12,14,15,19)/t3-,4+,6-,9-/m0/s1

Synonyms: L-2'-F-Ara-Guanosine; 9-(2-Fluoro-2-deoxy-β-L-arabinofuranosyl)guanine; 6H-Purin-6-one, 2-amino-9-(2-deoxy-2-fluoro-β-L-arabinofuranosyl)-3,9-dihydro-; 2-Amino-9-(2-deoxy-2-fluoro-β-L-arabinofuranosyl)-3,9-dihydro-6H-purin-6-one; 2-amino-9-[(2S,3R,4S,5S)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]purin-6-ol; 6H-Purin-6-one, 2-amino-9-(2-deoxy-2-fluoro-β-L-arabinofuranosyl)-1,9-dihydro-; 2-Amino-9-(2-deoxy-2-fluoro-β-L-arabinofuranosyl)-1,9-dihydro-6H-purin-6-one

1-(2-Deoxy-2-fluoro-β-L-arabinofuranosyl)uracil

Description: 1-(2-Deoxy-2-fluoro-β-L-arabinofuranosyl)uracil is a modified nucleoside where uracil is attached to a β-L-arabinofuranosyl sugar with a 2-deoxy-2-fluoro modification. This modification enhances the stability and alters the chemical properties of the nucleoside, making it useful in nucleic acid chemistry for applications such as nucleotide analog synthesis and structural studies.

CAT: BRP-01595

CAS: 1312300-54-1

Molecular Formula: C9H11FN2O5

Molecular Weight: 246.19

Purity: ≥98%

Appearance: White to off-white powder

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Density: 1.63±0.1 g/cm3

InChIKey: UIYWFOZZIZEEKJ-UCVXFZOQSA-N

CanonicalSMILES: C1=CN(C(=O)NC1=O)C2C(C(C(O2)CO)O)F

IUPAC Name: 1-[(2S,3R,4S,5S)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione

InChI: InChI=1S/C9H11FN2O5/c10-6-7(15)4(3-13)17-8(6)12-2-1-5(14)11-9(12)16/h1-2,4,6-8,13,15H,3H2,(H,11,14,16)/t4-,6+,7-,8-/m0/s1

Synonyms: 1-((2S,3R,4S,5S)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; 2'-Deoxy-2'-fluoro-beta-L-arabinouridine; 1-(2-Deoxy-2-fluoro-β-L-arabinofuranosyl)-2,4(1H,3H)-pyrimidinedione; 2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-2-fluoro-β-L-arabinofuranosyl)-; 2'-Fluoro-5-ethyl-1-β-L-arabinofuranosyluracil

N,2'-O,3'-O-Triacetylcytidine

Description: N,2'-O,3'-O-Triacetylcytidine is an exceptional biomedical product, used for studying conspicuous viral infections, such as hepatitis C and influenza. It has the remarkable ability to impede viral RNA replication.

CAT: BRP-01628

CAS: 40632-06-2

Molecular Formula: C15H19N3O8

Molecular Weight: 369.33

Appearance: White to off-white powder

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Storage: Store at -20 °C

Density: 1.53±0.1 g/cm3

InChIKey: PWCGIZSEUGLASX-FMKGYKFTSA-N

CanonicalSMILES: CC(=O)NC1=NC(=O)N(C=C1)C2C(C(C(O2)CO)OC(=O)C)OC(=O)C

IUPAC Name: [(2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1-yl)-4-acetyloxy-2-(hydroxymethyl)oxolan-3-yl] acetate

InChI: InChI=1S/C15H19N3O8/c1-7(20)16-11-4-5-18(15(23)17-11)14-13(25-9(3)22)12(24-8(2)21)10(6-19)26-14/h4-5,10,12-14,19H,6H2,1-3H3,(H,16,17,20,23)/t10-,12-,13-,14-/m1/s1

Synonyms: N4-acetyl-2',3'-diacetyl-cytidine; 2',3'-diAc-C(Ac); Cytidine, N-acetyl-, 2',3'-diacetate; (2R,3R,4R,5R)-2-(4-Acetamido-2-oxopyrimidin-1(2H)-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diyl diacetate; N-Acetyl-2',3'-di-O-acetylcytidine

5'-O-(4,4'-Dimethoxytrityl)-N2-isobutyryl-2'-O,4'-C-methyleneguanosine

Description: 5'-O-(4,4'-Dimethoxytrityl)-N2-isobutyryl-2'-O,4'-C-methyleneguanosine is a revolutionary biomedical substance renowned for its remarkable antiviral and antiproliferative attributes.

CAT: BRP-01629

CAS: 206055-72-3

Molecular Formula: C36H37N5O8

Molecular Weight: 667.71

Purity: ≥95%

Appearance: Off-white to yellow powder

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Storage: Store at -20 °C

Density: 1.41±0.1 g/cm3

InChIKey: JMGQUFRCVHVMAX-UBMDZZGASA-N

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C4C(C(O3)(CO4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC)O

IUPAC Name: N-[9-[(1R,3R,4R,7S)-1-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-7-hydroxy-2,5-dioxabicyclo[2.2.1]heptan-3-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide

InChI: InChI=1S/C36H37N5O8/c1-21(2)31(43)39-34-38-30-27(32(44)40-34)37-20-41(30)33-28-29(42)35(49-33,18-47-28)19-48-36(22-8-6-5-7-9-22,23-10-14-25(45-3)15-11-23)24-12-16-26(46-4)17-13-24/h5-17,20-21,28-29,33,42H,18-19H2,1-4H3,(H2,38,39,40,43,44)/t28-,29+,33-,35-/m1/s1

Synonyms: N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O-4'-C-Locked-guanosine; N2-iBu-DMT-2'-O-4'-C-Locked-Gr; N-(9-{(1R,3R,4R,7S)-1-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-7-hydroxy-2,5-dioxa-bicyclo[2.2.1]hept-3-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-isobutyramide; Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O,4'-C-methylene-N-(2-methyl-1-oxopropyl)-; (1R,3R,4R,7S)-1-(4,4'-Dimethoxytrityloxymethyl)-7-hydroxy-3-(2-N-isobutyrylguanin-9-yl)-2,5-dioxabicyclo[2.2.1]heptane

N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-5-methyl-2'-O,4'-C-methylenecytidine

Description: N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-5-methyl-2'-O,4'-C-methylenecytidine, a highly potent compound extensively employed in the biomedical field, exhibits exceptional efficacy in combatting viral infections. This compound particularly exhibits remarkable proficiency against RNA viruses, such as SARS-CoV-2, ensuring its pervasive usefulness. By engaging viral RNA polymerase, it effectively impedes viral replication, thereby portraying its indispensable antiviral attributes.

CAT: BRP-01630

CAS: 445012-77-1

Molecular Formula: C39H37N3O8

Molecular Weight: 675.73

Purity: ≥98% by HPLC

Appearance: White, off-white to faint yellow powder

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Storage: Store at 2-8 °C, in tightly closed container, protected from light and humidity

Density: 1.32±0.1 g/cm3

InChIKey: CTGWFRQUULNNIN-OSZGUBSQSA-N

CanonicalSMILES: CC1=CN(C(=O)N=C1NC(=O)C2=CC=CC=C2)C3C4C(C(O3)(CO4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC)O

IUPAC Name: N-(1-((1R,3R,4R,7S)-1-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-7-hydroxy-2,5-dioxabicyclo[2.2.1]heptan-3-yl)-5-methyl-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide

InChI: InChI=1S/C39H37N3O8/c1-25-22-42(37(45)41-34(25)40-35(44)26-10-6-4-7-11-26)36-32-33(43)38(50-36,23-48-32)24-49-39(27-12-8-5-9-13-27,28-14-18-30(46-2)19-15-28)29-16-20-31(47-3)21-17-29/h4-22,32-33,36,43H,23-24H2,1-3H3,(H,40,41,44,45)/t32-,33+,36-,38-/m1/s1

Synonyms: N4-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-4'-C-Locked-5-methyl-cytidine; N-(1-((1R,3R,4R,7S)-1-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-7-hydroxy-2,5-dioxabicyclo[2.2.1]heptan-3-yl)-5-methyl-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide; Benzamide, N-[1-[2,5-anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-α-L-lyxofuranosyl]-1,2-dihydro-5-methyl-2-oxo-4-pyrimidinyl]-; N-[1-[2,5-Anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-α-L-lyxofuranosyl]-1,2-dihydro-5-methyl-2-oxo-4-pyrimidinyl]benzamide; N4-Bz-DMT-2'-O-4'-C-Locked-5-Me-Cr

3'-O-TBDMS-2'-F-dA(Bz)

3'-O-TBDMS-2'-F-dG(iBu)

5'-O-DMT-N4-Acetyl-2'-fluoro-5-methyl-2'-deoxycytidine

N4-Acetyl-5-Iodo-2'-fluoro-2'-deoxycytidine

5'-O-(4,4'-Dimethoxytrityl)-N2-dimethylformamidine-2'-fluoro-2'-deoxyguanosine

N1-Methylene pivalate-N2-dibutylformamidine-2'-fluoro-guanosine

N4-Dibutylformamidine-2'-fluoro-deoxycytidine

N2-Dibutylformamidine-2'-fluoro-guanosine

N2-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-deoxyguanosine

N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-3'-O-succinate-2'-fluoro-deoxyguanosine, triethylamine salt

N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-3'-O-succinate-2'-fluoro-deoxyadenosine, triethylamine salt

N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-3'-O-succinate-2'-fluoro-deoxycytidine, triethylamine salt

5'-O-DMT-3'-O-succinate-2'-F-deoxyuridine, triethylamine salt

1-(2-Fluoro-2-deoxy-β-L-arabinofuranosyl)cytosine

9-(2'-Fluoro-2'-deoxy-β-L-arabinofuranosyl)adenine

9-(2-Deoxy-2-fluoro-β-L-arabinofuranosyl)guanine

1-(2-Deoxy-2-fluoro-β-L-arabinofuranosyl)uracil

N,2'-O,3'-O-Triacetylcytidine

5'-O-(4,4'-Dimethoxytrityl)-N2-isobutyryl-2'-O,4'-C-methyleneguanosine

N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-5-methyl-2'-O,4'-C-methylenecytidine

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